Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PUS7	54517	broad.mit.edu	37	7	105142964	105142964	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:105142964G>A	ENST00000356362.2	-	5	847	c.633C>T	c.(631-633)atC>atT	p.I211I	PUS7_ENST00000469408.1_Silent_p.I211I	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	211					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						ACAGAGATTTGATAGCCTGAT	0.398000													50	50					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33591757	33591757	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:33591757C>T	ENST00000299977.4	+	4	1842	c.1694C>T	c.(1693-1695)tCa>tTa	p.S565L	SLFN5_ENST00000542451.1_Intron	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	565					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GAGTTGCTTTCAAAGAACCTT	0.438000													54	149					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52876970	52876970	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:52876970C>T	ENST00000356971.3	-	11	1697	c.1208G>A	c.(1207-1209)aGa>aAa	p.R403K	ICK_ENST00000350082.5_Missense_Mutation_p.R403K	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	403					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					ACCCCACCTTCTCCTACTCTT	0.458000													15	51					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3174631	3174631	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:3174631C>T	ENST00000381075.2	+	20	2108	c.1884C>T	c.(1882-1884)ctC>ctT	p.L628L	PFKP_ENST00000381072.1_Silent_p.L54L|PFKP_ENST00000381125.4_Silent_p.L636L	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	636					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		GCCTTGTGCTCAGGTGAGAGA	0.488000													37	84					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197889112	197889112	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:197889112C>T	ENST00000367390.3	+	3	185	c.158C>T	c.(157-159)cCg>cTg	p.P53L	LHX9_ENST00000367391.1_Missense_Mutation_p.P53L|LHX9_ENST00000561173.1_Missense_Mutation_p.P68L|LHX9_ENST00000367387.4_Missense_Mutation_p.P62L|LHX9_ENST00000337020.2_Missense_Mutation_p.P62L	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	62					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GGCATGCCCCCGCTCAGCCCG	0.667000													67	88					0	0	1	0	0
C9orf64	84267	broad.mit.edu	37	9	86570437	86570437	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:86570437G>A	ENST00000376344.3	-	2	672	c.456C>T	c.(454-456)ctC>ctT	p.L152L	C9orf64_ENST00000376340.2_Silent_p.L11L|C9orf64_ENST00000314700.1_Silent_p.L11L	NM_032307.3	NP_115683.3	Q5T6V5	CI064_HUMAN	chromosome 9 open reading frame 64	152										central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						CGGTTTCATTGAGAATCCGAT	0.483000													39	82					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132687361	132687361	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:132687361G>C	ENST00000420781.1	-	9	1083	c.865C>G	c.(865-867)Cag>Gag	p.Q289E	FNBP1_ENST00000355681.3_Missense_Mutation_p.Q289E|FNBP1_ENST00000478129.1_5'UTR|FNBP1_ENST00000446176.2_Missense_Mutation_p.Q289E			Q96RU3	FNBP1_HUMAN	formin binding protein 1	289	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		TTCATTGGCTGAGTGTAATCC	0.413000			T	MLL	AML								37	65					0	0	1	0	0
LMCD1	29995	broad.mit.edu	37	3	8590521	8590521	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:8590521G>A	ENST00000157600.3	+	4	887	c.655G>A	c.(655-657)Gag>Aag	p.E219K	LMCD1-AS1_ENST00000439407.1_RNA|LMCD1_ENST00000454244.1_Missense_Mutation_p.E146K|LMCD1_ENST00000397386.3_Missense_Mutation_p.E107K|LMCD1_ENST00000535732.1_Missense_Mutation_p.E219K	NM_014583.2	NP_055398.1	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	219					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)	16				OV - Ovarian serous cystadenocarcinoma(96;0.124)		GGAAAAGCCAGAGGGGGCAGA	0.597000													29	49					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053024	11053024	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:11053024G>A	ENST00000295082.1	+	1	962	c.472G>A	c.(472-474)Gag>Aag	p.E158K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	158						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GGACGCAGCCGAGGGCCGCTG	0.692000													39	62					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007880	6007880	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:6007880G>C	ENST00000332249.4	-	1	335	c.281C>G	c.(280-282)tCc>tGc	p.S94C		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGTGCAGTGGAGGAGGCCAG	0.527000													15	13					0	0	1	0	0
MRFAP1	93621	broad.mit.edu	37	4	6642650	6642650	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:6642650G>A	ENST00000320912.4	+	2	714	c.61G>A	c.(61-63)Gag>Aag	p.E21K	MRFAP1_ENST00000382581.4_Missense_Mutation_p.E21K|MRFAP1_ENST00000507420.1_Missense_Mutation_p.E21K	NM_001272053.1	NP_001258982.1	Q9Y605	MOFA1_HUMAN	Morf4 family associated protein 1	21						nucleus|perinuclear region of cytoplasm	protein binding			lung(1)	1						GCTGGAGCCCGAGGAGGATTT	0.642000													9	131					0	0	1	0	0
UBIAD1	29914	broad.mit.edu	37	1	11333645	11333645	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:11333645C>T	ENST00000376810.5	+	1	383	c.57C>T	c.(55-57)gtC>gtT	p.V19V	UBIAD1_ENST00000376804.2_Silent_p.V19V	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	19					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GAGAGACTGTCAAAGCTGGGG	0.597000													9	61					0	0	1	0	0
PANK3	79646	broad.mit.edu	37	5	168006268	168006268	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:168006268C>T	ENST00000239231.6	-	1	337	c.21G>A	c.(19-21)aaG>aaA	p.K7K		NM_024594.3	NP_078870.1	Q9H999	PANK3_HUMAN	pantothenate kinase 3	7					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			NS(1)|cervix(2)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TACAGGGTTTCTTGGCATCTT	0.692000													11	19					0	0	1	0	0
TNIP3	79931	broad.mit.edu	37	4	122068306	122068306	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:122068306G>A	ENST00000454328.1	-	9	860	c.633C>T	c.(631-633)ttC>ttT	p.F211F	TNIP3_ENST00000507879.1_Silent_p.F281F|TNIP3_ENST00000509841.1_Silent_p.F288F|TNIP3_ENST00000057513.3_Silent_p.F211F|TNIP3_ENST00000511909.1_5'UTR			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	211										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						GTTCCTTTTTGAAGTCTTCTT	0.363000													6	49					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187540046	187540046	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:187540046G>A	ENST00000441802.2	-	10	7903	c.7694C>T	c.(7693-7695)tCa>tTa	p.S2565L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2565	Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TAAACGGACTGAGATCACTTT	0.413000										HNSCC(5;0.00058)			9	31					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58134041	58134041	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:58134041C>T	ENST00000357272.4	+	35	6002	c.5837C>T	c.(5836-5838)tCt>tTt	p.S1946F	FLNB_ENST00000419752.2_Missense_Mutation_p.S1766F|FLNB_ENST00000295956.4_Missense_Mutation_p.S1946F|FLNB_ENST00000348383.5_Missense_Mutation_p.S1946F|FLNB_ENST00000493452.1_Missense_Mutation_p.S1753F|FLNB_ENST00000358537.3_Missense_Mutation_p.S1922F|FLNB_ENST00000490882.1_Missense_Mutation_p.S1977F|FLNB_ENST00000429972.2_Missense_Mutation_p.S1935F			O75369	FLNB_HUMAN	filamin B, beta	1946	Interaction with the cytoplasmic tail of GP1BA.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		AAGGCCCCATCTGGCCGAGAC	0.612000													14	26					0	0	1	0	0
PRMT6	55170	broad.mit.edu	37	1	107599529	107599529	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:107599529C>T	ENST00000361318.5	+	1	263	c.15C>T	c.(13-15)cgC>cgT	p.R5R	PRMT6_ENST00000370078.1_Silent_p.R64R	NM_018137.2	NP_060607.2	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	64					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			biliary_tract(1)|breast(2)|kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	14		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		TCGCGGACCGCGTCCGCACCG	0.657000													13	39					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90049514	90049514	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:90049514G>A	ENST00000405460.2	+	54	11341	c.11245G>A	c.(11245-11247)Gac>Aac	p.D3749N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3749					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGGGGTTGAGGACTCATACAA	0.448000													20	45					0	0	1	0	0
PPM1G	5496	broad.mit.edu	37	2	27606329	27606329	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:27606329C>G	ENST00000344034.4	-	7	1369	c.1105G>C	c.(1105-1107)Gag>Cag	p.E369Q	PPM1G_ENST00000350803.4_Missense_Mutation_p.E369Q	NM_177983.2	NP_817092.1	O15355	PPM1G_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1G	369					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity	p.E369*(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					ACTTCATCCTCTGGTTTGTGA	0.517000													24	118					0	0	1	0	0
RNF207	388591	broad.mit.edu	37	1	6272368	6272368	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:6272368C>T	ENST00000377939.4	+	14	1501	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L	RNF207_ENST00000377948.2_3'UTR	NM_207396.2	NP_997279.2	Q6ZRF8	RN207_HUMAN	ring finger protein 207	458						intracellular	zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(2)	16	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		ACCACTCGCTCATCAAGGCGG	0.597000													32	47					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71591368	71591368	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:71591368C>T	ENST00000409544.1	+	5	2333	c.1703C>T	c.(1702-1704)tCa>tTa	p.S568L	ZNF638_ENST00000264447.4_Missense_Mutation_p.S568L|ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000377802.2_Missense_Mutation_p.S568L|ZNF638_ENST00000355812.3_Missense_Mutation_p.S568L	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	568	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TCAAGGAGATCAGTGAGATCA	0.368000													30	54					0	0	1	0	0
ANP32A	8125	broad.mit.edu	37	15	69076812	69076812	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:69076812C>T	ENST00000465139.2	-	4	593	c.450G>A	c.(448-450)cgG>cgA	p.R150R	ANP32A_ENST00000560303.1_Silent_p.R150R|ANP32A_ENST00000483551.2_5'UTR	NM_006305.3	NP_006296.1	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	150	LRRCT.|Necessary for tumor-suppressive function.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding			endometrium(1)|large_intestine(1)|lung(2)	4						CCTTGTCGTCCCGGTCATAGC	0.572000													21	47					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72462872	72462872	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:72462872C>G	ENST00000360141.3	+	1	318	c.30C>G	c.(28-30)ctC>ctG	p.L10L	CD300A_ENST00000392625.3_Silent_p.L10L|CD300A_ENST00000361933.3_Silent_p.L10L|CD300A_ENST00000310828.5_Silent_p.L10L	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	10					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						TGTTGCTTCTCTGGGTCCCAG	0.667000													3	14					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139151323	139151323	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:139151323C>T	ENST00000395297.1	-	18	3977	c.3807G>A	c.(3805-3807)caG>caA	p.Q1269Q		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1269										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCTTCAGTTTCTGCATGAGCC	0.388000										HNSCC(54;0.14)			24	54					0	0	1	0	0
ARNTL	406	broad.mit.edu	37	11	13407235	13407235	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:13407235G>A	ENST00000389708.3	+	19	2067		c.e19-1		ARNTL_ENST00000403510.3_Splice_Site|ARNTL_ENST00000396441.3_Splice_Site|ARNTL_ENST00000361003.4_Splice_Site|ARNTL_ENST00000401424.1_Splice_Site|ARNTL_ENST00000403482.3_Splice_Site|ARNTL_ENST00000389707.4_Splice_Site|ARNTL_ENST00000403290.1_Splice_Site			O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear translocator-like						circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(11)|lung(5)|upper_aerodigestive_tract(1)	20				Epithelial(150;0.0243)		TTTGTTTGTAGATTTTAAATG	0.443000													9	27					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265466	10265466	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:10265466G>A	ENST00000418404.3	-	4	637	c.474C>T	c.(472-474)atC>atT	p.I158I	MYH13_ENST00000252172.4_Silent_p.I158I			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	158	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CATTGTCAGAGATGGAGAAGA	0.498000													8	202					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48641625	48641625	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:48641625G>C	ENST00000518074.1	+	18	2557	c.2386G>C	c.(2386-2388)Gag>Cag	p.E796Q	SPIDR_ENST00000521214.1_Intron|SPIDR_ENST00000541342.1_Intron|SPIDR_ENST00000517693.1_Intron|SPIDR_ENST00000518060.1_Intron|SPIDR_ENST00000297423.4_Intron	NM_001282919.1	NP_001269848.1			scaffolding protein involved in DNA repair																		AGCCAGGCCAGAGCACGCACG	0.602000													14	31					0	0	1	0	0
FRRS1	391059	broad.mit.edu	37	1	100177720	100177720	+	Splice_Site	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:100177720C>T	ENST00000414213.1	-	14	2023		c.e14-1		FRRS1_ENST00000287474.5_Splice_Site|FRRS1_ENST00000492943.1_Splice_Site			Q6ZNA5	FRRS1_HUMAN	ferric-chelate reductase 1						electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	26		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		CATTTGCCTTCTACCAAAATA	0.333000													34	56					0	0	1	0	0
METTL18	92342	broad.mit.edu	37	1	169761959	169761959	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:169761959G>A	ENST00000310392.4	-	2	1231	c.878C>T	c.(877-879)tCa>tTa	p.S293L	C1orf112_ENST00000498289.1_Intron|METTL18_ENST00000303469.2_Missense_Mutation_p.S293L	NM_033418.2	NP_219486.1	O95568	MET18_HUMAN	methyltransferase like 18	293						cytoplasm	protein methyltransferase activity			kidney(1)|large_intestine(3)|lung(4)	8						AATGGTTTCTGAGGTGAGAAT	0.343000													11	22					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37117520	37117520	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:37117520G>A	ENST00000435416.1	+	3	2213	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	ZNF382_ENST00000423582.1_Missense_Mutation_p.E192K|ZNF382_ENST00000292928.2_Missense_Mutation_p.E241K|ZNF382_ENST00000439428.1_Missense_Mutation_p.E240K			Q96SR6	ZN382_HUMAN	zinc finger protein 382	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAGAACCTTTGAATACAATAA	0.383000													28	42					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34618459	34618459	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:34618459G>A	ENST00000373973.3	+	12	1793	c.1620G>A	c.(1618-1620)acG>acA	p.T540T	CNBD2_ENST00000349339.1_Silent_p.T536T|CNBD2_ENST00000538900.1_3'UTR					cyclic nucleotide binding domain containing 2																		TCAACAAGACGACTAAACCTC	0.478000													145	236					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247150906	247150906	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:247150906G>A	ENST00000339986.7	-	4	1058	c.911C>T	c.(910-912)tCc>tTc	p.S304F	ZNF695_ENST00000487338.2_Intron|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein 695	304					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CAACTTAAAGGATTTGCCACA	0.358000													6	12					0	0	1	0	0
TBC1D13	54662	broad.mit.edu	37	9	131566386	131566386	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:131566386C>G	ENST00000372648.5	+	9	1056	c.906C>G	c.(904-906)ctC>ctG	p.L302L	TBC1D13_ENST00000539497.1_Silent_p.L121L|TBC1D13_ENST00000223865.8_Intron	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	302	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						ATGTGGAGCTCTACCTGAAAC	0.547000													26	47					0	0	1	0	0
IAH1	285148	broad.mit.edu	37	2	9616125	9616125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:9616125C>T	ENST00000497473.1	+	2	128	c.91C>T	c.(91-93)Cag>Tag	p.Q31*	IAH1_ENST00000545602.1_Intron|IAH1_ENST00000482918.1_5'UTR|IAH1_ENST00000489468.1_3'UTR|IAH1_ENST00000470914.1_Intron	NM_001039613.1	NP_001034702.1	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)	31					lipid catabolic process		hydrolase activity, acting on ester bonds			breast(1)|large_intestine(2)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTTTTCCTTCCAGCAGGGTGG	0.493000													12	19					0	0	1	0	0
FOXQ1	94234	broad.mit.edu	37	6	1313374	1313374	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:1313374C>T	ENST00000296839.2	+	1	700	c.435C>T	c.(433-435)atC>atT	p.I145I		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	145					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TGGCGGAGATCAACGAGTACC	0.642000													32	29					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22052311	22052311	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:22052311C>T	ENST00000306385.5	+	12	2188	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	BMP1_ENST00000397814.3_Silent_p.I506I|BMP1_ENST00000397816.3_Silent_p.I506I|BMP1_ENST00000354870.5_3'UTR|BMP1_ENST00000306349.8_Silent_p.I506I	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	506	CUB 2.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCACCCTCATCGGGCGCTACT	0.587000													26	65					0	0	1	0	0
TLX2	3196	broad.mit.edu	37	2	74743161	74743161	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:74743161C>T	ENST00000233638.7	+	3	1023	c.700C>T	c.(700-702)Ctg>Ttg	p.L234L		NM_016170.4	NP_057254.1	O43763	TLX2_HUMAN	T-cell leukemia homeobox 2	234						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|ovary(1)	2						GCTCCTGCATCTGCAGCAGGA	0.761000													11	15					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28605669	28605669	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:28605669A>G	ENST00000253063.3	+	9	1594	c.1273A>G	c.(1273-1275)Atc>Gtc	p.I425V		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	425					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGGTCTATATCAAGACAGT	0.502000													28	69					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169021605	169021605	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:169021605C>T	ENST00000265295.4	+	7	1090	c.811C>T	c.(811-813)Cag>Tag	p.Q271*	SPDL1_ENST00000510751.1_3'UTR	NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		AATGGAACGTCAGCTCATCAG	0.343000													26	45					0	0	1	0	0
DOK1	1796	broad.mit.edu	37	2	74783531	74783531	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:74783531G>C	ENST00000233668.5	+	5	1405	c.736G>C	c.(736-738)Gag>Cag	p.E246Q	DOK1_ENST00000340004.6_3'UTR|DOK1_ENST00000409429.1_Missense_Mutation_p.E107Q|DOK1_ENST00000480318.1_3'UTR	NM_001381.3	NP_001372.1	Q99704	DOK1_HUMAN	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	246	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding			endometrium(3)|large_intestine(2)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CCAGGCAGTTGAGACTGCCAT	0.607000													58	56					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14863080	14863080	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:14863080G>C	ENST00000285046.5	+	1	2612	c.2502G>C	c.(2500-2502)caG>caC	p.Q834H	FGD5_ENST00000543601.1_Missense_Mutation_p.Q593H	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	834					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GCAAACAGCAGAGTGCAGACC	0.522000													29	42					0	0	1	0	0
PRRC1	133619	broad.mit.edu	37	5	126860289	126860289	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:126860289C>T	ENST00000442138.2	+	3	316	c.170C>T	c.(169-171)tCt>tTt	p.S57F	PRRC1_ENST00000296666.8_Missense_Mutation_p.S57F|PRRC1_ENST00000512635.2_Missense_Mutation_p.S57F			Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	57	Pro-rich.					Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		CTCGCATACTCTACTCCTCAG	0.493000													89	130					0	0	1	0	0
CDC37	11140	broad.mit.edu	37	19	10503962	10503962	+	Silent	SNP	G	G	A	rs138014063	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10503962G>A	ENST00000222005.2	-	6	935	c.882C>T	c.(880-882)ccC>ccT	p.P294P		NM_007065.3	NP_008996.1	Q16543	CDC37_HUMAN	cell division cycle 37	294					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	16			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		AGACCTCGACGGGGTCCAGGC	0.721000													14	39					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224570	26224570	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:26224570G>T	ENST00000056233.3	+	4	1511	c.1252G>T	c.(1252-1254)Gat>Tat	p.D418Y		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	418					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						ACCAGATTCTGATTCTGGCCT	0.363000													51	51					2.43139e-17	2.52328e-17	1	1	0
PMS2P3	5387	broad.mit.edu	37	7	75156979	75156979	+	RNA	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:75156979G>A	ENST00000418756.1	-	0	474					NR_028059.1															lung(1)	1						GTCTGCTCGCGAGGTCCCCTC	0.726000													4	24					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631037	99631037	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99631037G>A	ENST00000324306.6	+	6	1143	c.909G>A	c.(907-909)gaG>gaA	p.E303E	ZKSCAN1_ENST00000535170.1_Silent_p.E90E|ZKSCAN1_ENST00000426572.1_Silent_p.E267E	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	303					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGTTTGGAGAGAAACGTGACC	0.488000													12	58					0	0	1	0	0
ZNF566	84924	broad.mit.edu	37	19	36940789	36940789	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:36940789G>A	ENST00000454319.1	-	5	484	c.350C>T	c.(349-351)tCc>tTc	p.S117F	ZNF566_ENST00000434377.2_Missense_Mutation_p.S116F|ZNF566_ENST00000424129.2_Missense_Mutation_p.S116F|ZNF566_ENST00000493391.1_Missense_Mutation_p.S12F|ZNF566_ENST00000392170.2_Missense_Mutation_p.S117F	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					TCTGAAACTGGAGCACTGAAA	0.378000													72	108					0	0	1	0	0
ZBTB5	9925	broad.mit.edu	37	9	37441286	37441286	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:37441286A>C	ENST00000307750.4	-	2	1451	c.1263T>G	c.(1261-1263)ttT>ttG	p.F421L		NM_014872.2	NP_055687.1	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		GATTTGCAGTAAAGTTATTTC	0.413000													19	53					0	0	1	0	0
PGAM4	441531	broad.mit.edu	37	X	77224590	77224590	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:77224590C>G	ENST00000458128.1	-	1	545	c.546G>C	c.(544-546)ctG>ctC	p.L182L	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000341514.6_Intron|ATP7A_ENST00000343533.5_Intron	NM_001029891.2	NP_001025062.1	Q8N0Y7	PGAM4_HUMAN	phosphoglycerate mutase family member 4	182					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						GGGCTGCAATCAGTACACGTT	0.527000													52	27					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99490261	99490261	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99490261G>A	ENST00000355947.2	-	7	1157	c.1028C>T	c.(1027-1029)tCa>tTa	p.S343L	TRIM4_ENST00000349062.2_Missense_Mutation_p.S317L	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	343	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				GTTCCATGCTGAAGAAAACAC	0.458000													55	60					0	0	1	0	0
HSD11B2	3291	broad.mit.edu	37	16	67470217	67470217	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:67470217G>T	ENST00000326152.5	+	4	862	c.730G>T	c.(730-732)Gac>Tac	p.D244Y		NM_000196.3	NP_000187.3	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	244			D -> N (in AME; associated with R-250).		glucocorticoid biosynthetic process	endoplasmic reticulum|microsome				breast(1)|endometrium(1)|liver(2)|lung(3)|upper_aerodigestive_tract(1)	8		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	GCTACTCATGGACACATTCAG	0.607000													78	126					1.72036e-36	1.79845e-36	1	1	0
TNPO2	30000	broad.mit.edu	37	19	12825888	12825888	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:12825888G>A	ENST00000425528.1	-	9	1101	c.744C>T	c.(742-744)ctC>ctT	p.L248L	TNPO2_ENST00000589956.1_Intron|TNPO2_ENST00000356861.5_Silent_p.L248L|TNPO2_ENST00000588216.1_Silent_p.L248L|TNPO2_ENST00000450764.2_Silent_p.L248L|TNPO2_ENST00000592287.1_Silent_p.L248L|TNPO2_ENST00000441499.1_Silent_p.L248L			O14787	TNPO2_HUMAN	transportin 2	248					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGTGGGGGATGAGCCTGTCAA	0.642000													32	36					0	0	1	0	0
MRPL47	57129	broad.mit.edu	37	3	179306756	179306756	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:179306756G>A	ENST00000476781.1	-	7	686	c.657C>T	c.(655-657)atC>atT	p.I219I	MRPL47_ENST00000259038.2_Silent_p.I199I|MRPL47_ENST00000392659.2_Silent_p.I109I	NM_020409.2	NP_065142.2	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47	219					translation	mitochondrial ribosome	structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|stomach(1)	11	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			TCCGTGCTTTGATGCGGGCTC	0.333000													16	39					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961582	34961582	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:34961582C>T	ENST00000329357.5	+	1	670	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	212	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GTCCAGTCGCCGCCCAGAGCC	0.652000													46	24					0	0	1	0	0
KDM8	79831	broad.mit.edu	37	16	27221637	27221637	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:27221637C>T	ENST00000286096.4	+	2	366	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L	KDM8_ENST00000380948.2_Silent_p.L65L|KDM8_ENST00000441782.2_Silent_p.L103L|KDM8_ENST00000568965.1_Silent_p.L65L	NM_024773.2	NP_079049.2	Q8N371	KDM8_HUMAN	lysine (K)-specific demethylase 8	65					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen										GGACGAGTGTCTGCAGAGCAG	0.597000													16	57					0	0	1	0	0
CCDC103	388389	broad.mit.edu	37	17	42979948	42979948	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:42979948G>A	ENST00000417826.2	+	4	587	c.492G>A	c.(490-492)ctG>ctA	p.L164L	FAM187A_ENST00000412523.2_Intron|CCDC103_ENST00000410006.2_Silent_p.L164L|FAM187A_ENST00000331733.4_5'UTR	NM_001258399.1|NM_213607.2	NP_001245328.1|NP_998772.1	Q8IW40	CC103_HUMAN	coiled-coil domain containing 103	164										endometrium(1)|kidney(1)|large_intestine(3)|prostate(1)|skin(1)	7		Prostate(33;0.109)				CAGCGGTGCTGGGGATCCTAT	0.627000													53	87					0	0	1	0	0
TAS2R20	259295	broad.mit.edu	37	12	11150347	11150347	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:11150347G>A	ENST00000538986.1	-	1	127	c.128C>T	c.(127-129)tCa>tTa	p.S43L	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	43					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						TTGATCAGCTGAGGAGATCTT	0.383000													24	52					0	0	1	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820259	179820259	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:179820259G>C	ENST00000367612.3	-	4	661	c.274C>G	c.(274-276)Cag>Gag	p.Q92E	TOR1AIP2_ENST00000609928.1_Missense_Mutation_p.Q92E	NM_145034.4	NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	92						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						AGAAAACTCTGCTTGTTCTCA	0.448000													13	36					0	0	1	0	0
WDR20	91833	broad.mit.edu	37	14	102606455	102606455	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:102606455C>T	ENST00000322340.5	+	1	244	c.195C>T	c.(193-195)ctC>ctT	p.L65L	WDR20_ENST00000454394.2_Silent_p.L65L|WDR20_ENST00000558567.1_Silent_p.L65L|WDR20_ENST00000299135.6_Silent_p.L65L|WDR20_ENST00000557186.1_3'UTR|WDR20_ENST00000424963.2_5'UTR|WDR20_ENST00000556511.2_Silent_p.L65L|WDR20_ENST00000556807.1_Silent_p.L65L|WDR20_ENST00000335263.5_Silent_p.L65L|WDR20_ENST00000499851.2_5'UTR|WDR20_ENST00000342702.3_Silent_p.L65L	NM_001242415.1	NP_001229344.1	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20	65								p.L65L(1)		breast(1)|large_intestine(2)|lung(4)|prostate(1)	8						GCGACCGCCTCTGCTTCAATG	0.637000													22	44					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987343	7987343	+	Silent	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:7987343C>A	ENST00000221573.6	+	5	750	c.699C>A	c.(697-699)gtC>gtA	p.V233V	SNAPC2_ENST00000597584.1_5'UTR	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	233					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						CCGCTGTGGTCCTCGACCTGC	0.632000													33	88					8.4185e-14	8.68614e-14	1	1	0
CDC42BPB	9578	broad.mit.edu	37	14	103406202	103406202	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:103406202G>A	ENST00000361246.2	-	33	4962	c.4674C>T	c.(4672-4674)ttC>ttT	p.F1558F		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1558					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CTGGGACCTTGAAGACGAACC	0.632000													101	206					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	90997678	90997678	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:90997678G>A	ENST00000268182.5	+	14	1630	c.1506G>A	c.(1504-1506)atG>atA	p.M502I	IQGAP1_ENST00000560738.1_Intron	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	502					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			ATGAGTTGATGAAACTGAAGG	0.438000													23	60					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21407314	21407314	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:21407314C>G	ENST00000313654.9	+	23	2947	c.2706C>G	c.(2704-2706)ttC>ttG	p.F902L	LAMA3_ENST00000399516.3_Missense_Mutation_p.F902L	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	902	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGACCAGATTCCCCTGTACCC	0.507000													7	158					0	0	1	0	0
METTL2A	339175	broad.mit.edu	37	17	60503990	60503990	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:60503990C>T	ENST00000311506.5	+	3	569	c.533C>T	c.(532-534)tCc>tTc	p.S178F		NM_181725.3	NP_859076.3	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	178							methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|upper_aerodigestive_tract(2)	6			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			TTTCCTGGATCCTCAGCCACC	0.418000													9	14					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50727979	50727979	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:50727979G>A	ENST00000449103.1	-	3	1175	c.1035C>T	c.(1033-1035)ttC>ttT	p.F345F	PLXNB2_ENST00000359337.4_Silent_p.F345F			O15031	PLXB2_HUMAN	plexin B2	345	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TATCGCCGTGGAAGGGCTTGT	0.657000													12	25					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33165320	33165320	+	Nonstop_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:33165320G>C	ENST00000375030.2	+	23	2381	c.1763G>C	c.(1762-1764)tGa>tCa	p.*588S	C10orf68_ENST00000375025.4_Nonstop_Mutation_p.*693S|C10orf68_ENST00000375028.3_Nonstop_Mutation_p.*633S			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	0										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						CCATACTTTTGAGAATGAAGG	0.328000													14	25					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742373	10742373	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10742373G>A	ENST00000586078.1	+	8	683	c.574G>A	c.(574-576)Gag>Aag	p.E192K	SLC44A2_ENST00000335757.5_Missense_Mutation_p.E192K|SLC44A2_ENST00000407327.4_Missense_Mutation_p.E190K	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	192					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GACGACCTATGAGGATGGGCA	0.602000													17	42					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806295	54806295	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:54806295C>T	ENST00000306858.7	+	5	2642	c.2526C>T	c.(2524-2526)atC>atT	p.I842I		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	842										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AAGGCAGCATCCACAAGAGTA	0.398000													14	44					0	0	1	0	0
DUSP14	11072	broad.mit.edu	37	17	35872428	35872428	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:35872428G>A	ENST00000487847.1	+	2	1032	c.54G>A	c.(52-54)atG>atA	p.M18I	DUSP14_ENST00000394386.1_Missense_Mutation_p.M18I|DUSP14_ENST00000394389.4_Missense_Mutation_p.M18I			O95147	DUS14_HUMAN	dual specificity phosphatase 14	18							MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|urinary_tract(1)	9		Breast(25;0.00637)|Ovarian(249;0.15)				CCCCTCGGATGATTTCCGAGG	0.577000													14	30					0	0	1	0	0
ZPBP2	124626	broad.mit.edu	37	17	38027740	38027740	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:38027740G>A	ENST00000377940.3	+	3	341	c.202G>A	c.(202-204)Gaa>Aaa	p.E68K	ZPBP2_ENST00000348931.4_Missense_Mutation_p.E90K|ZPBP2_ENST00000584588.1_Missense_Mutation_p.E90K	NM_198844.2	NP_942141.2	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2	90			P -> A (in dbSNP:rs35591738).		binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			AAATATAACTGAAACTGGACA	0.294000													33	76					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100182052	100182052	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:100182052C>T	ENST00000409236.2	-	18	3128	c.3016G>A	c.(3016-3018)Gaa>Aaa	p.E1006K	AFF3_ENST00000409579.1_Missense_Mutation_p.E1031K|AFF3_ENST00000356421.2_Missense_Mutation_p.E1031K|AFF3_ENST00000317233.4_Missense_Mutation_p.E1006K			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						AATGCTGCTTCAGCATAGTTC	0.383000													17	79					0	0	1	0	0
CENPB	1059	broad.mit.edu	37	20	3766646	3766646	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:3766646G>A	ENST00000379751.4	-	1	691	c.485C>T	c.(484-486)tCg>tTg	p.S162L		NM_001810.5	NP_001801.1	P07199	CENPB_HUMAN	centromere protein B, 80kDa	162					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8						ACTGCCCTCCGAGGGCACCGC	0.781000													6	1					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114254328	114254328	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:114254328G>C	ENST00000357077.4	+	29	3396	c.3343G>C	c.(3343-3345)Gat>Cat	p.D1115H	ANK2_ENST00000264366.6_Missense_Mutation_p.D1082H|ANK2_ENST00000394537.3_Missense_Mutation_p.D1115H|ANK2_ENST00000509550.1_Missense_Mutation_p.D291H|ANK2_ENST00000506722.1_Missense_Mutation_p.D1106H	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1082	Interaction with SPTBN1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTACACTGAAGATGAATTGAA	0.428000													12	74					0	0	1	0	0
EVI2B	2124	broad.mit.edu	37	17	29632365	29632365	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:29632365G>C	ENST00000330927.4	-	2	417	c.263C>G	c.(262-264)tCt>tGt	p.S88C	NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron|EVI2B_ENST00000577894.1_Missense_Mutation_p.S88C|EVI2B_ENST00000544462.1_Missense_Mutation_p.S103C|CTD-2370N5.3_ENST00000578584.1_3'UTR	NM_006495.3	NP_006486.3	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	88						cytoplasm|integral to plasma membrane		p.0?(8)|p.?(3)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	12		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTTTTCAGAAGAGGTATAGAC	0.478000													56	156					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088106	43088106	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:43088106G>A	ENST00000359467.3	-	5	2406	c.2292C>T	c.(2290-2292)ctC>ctT	p.L764L	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	764						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						GATGTACAATGAGATTTGACT	0.393000													51	112					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19956181	19956181	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:19956181C>T	ENST00000255006.6	+	8	1808	c.1659C>T	c.(1657-1659)ttC>ttT	p.F553F	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Intron	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	504					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GCGGGGTGTTCAGCTCCTTCA	0.587000													86	131					0	0	1	0	0
STYX	6815	broad.mit.edu	37	14	53224052	53224052	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:53224052G>C	ENST00000354586.4	+	6	612	c.319G>C	c.(319-321)Gat>Cat	p.D107H	STYX_ENST00000442123.2_Missense_Mutation_p.D107H|STYX_ENST00000556861.1_Intron	NM_145251.3	NP_660294.1	Q8WUJ0	STYX_HUMAN	serine/threonine/tyrosine interacting protein	107	Tyrosine-protein phosphatase.				protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(41;0.176)					GGAATTTATTGATGGGAGCTT	0.264000													11	20					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160104336	160104336	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:160104336C>T	ENST00000361216.3	+	14	1979	c.1890C>T	c.(1888-1890)atC>atT	p.I630I	ATP1A2_ENST00000392233.3_Silent_p.I630I	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	630					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCGTGGGCATCATATCAGAGG	0.542000													22	58					0	0	1	0	0
USP22	23326	broad.mit.edu	37	17	20919102	20919102	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:20919102G>C	ENST00000261497.4	-	6	1004	c.801C>G	c.(799-801)ctC>ctG	p.L267L	USP22_ENST00000537526.2_Silent_p.L255L|USP22_ENST00000455117.2_Intron	NM_015276.1	NP_056091.1	Q9UPT9	UBP22_HUMAN	ubiquitin specific peptidase 22	267					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	15						GGGCCGCGATGAGGAACTCGT	0.632000													14	51					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72026081	72026081	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:72026081G>A	ENST00000378743.3	-	15	3389	c.3031C>T	c.(3031-3033)Caa>Taa	p.Q1011*		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1011					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGTGAGGGTTGAGGTAAAGAA	0.388000													48	107					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34828416	34828416	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:34828416C>T	ENST00000373932.3	+	2	972	c.626C>T	c.(625-627)tCa>tTa	p.S209L	AAR2_ENST00000320849.4_Missense_Mutation_p.S209L|AAR2_ENST00000397286.3_Missense_Mutation_p.S209L	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		ATCCGCTTCTCAGAGCTGCCC	0.587000													39	122					0	0	1	0	0
HOXC6	3223	broad.mit.edu	37	12	54422347	54422347	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:54422347C>T	ENST00000243108.4	+	1	206	c.42C>T	c.(40-42)ctC>ctT	p.L14L	HOXC6_ENST00000394331.3_Intron|HOXC4_ENST00000303406.4_Intron|RP11-834C11.12_ENST00000513209.1_Intron|RP11-834C11.14_ENST00000512206.1_RNA	NM_004503.3	NP_004494.1	P09630	HXC6_HUMAN	homeobox C6	14					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCTGCCACCTCGCCGGGGGCC	0.522000													29	50					0	0	1	0	0
POP7	10248	broad.mit.edu	37	7	100304474	100304474	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:100304474C>T	ENST00000303151.4	+	2	283	c.21C>T	c.(19-21)ccC>ccT	p.P7P		NM_005837.2	NP_005828.2	O75817	POP7_HUMAN	processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)	7					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			endometrium(2)|kidney(1)|ovary(1)	4	Lung NSC(181;0.041)|all_lung(186;0.0581)					ACCGAGAGCCCCGCGGTGCTG	0.582000													18	136					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94834293	94834293	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:94834293G>C	ENST00000358746.2	-	33	3642	c.3344C>G	c.(3343-3345)tCt>tGt	p.S1115C		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1115							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						CTTTAAGATAGAGCTGTAAAG	0.433000													12	21					0	0	1	0	0
SNW1	22938	broad.mit.edu	37	14	78184411	78184411	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:78184411C>T	ENST00000555761.1	-	13	1739	c.1711G>A	c.(1711-1713)Gaa>Aaa	p.E571K	SNW1_ENST00000261531.7_3'UTR|SLIRP_ENST00000557431.1_Intron|SLIRP_ENST00000557623.1_Intron|SNW1_ENST00000554775.1_3'UTR			Q13573	SNW1_HUMAN	SNW domain containing 1	0					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		AGAGTTCATTCACTTTGGAGA	0.483000													44	98					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130536459	130536459	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:130536459C>T	ENST00000314830.8	-	2	438	c.325G>A	c.(325-327)Gga>Aga	p.G109R		NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	109					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGTACACCTCCGGGTACCAAG	0.637000													13	24					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55473543	55473543	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:55473543C>T	ENST00000394600.3	-	11	1772	c.1036G>A	c.(1036-1038)Gaa>Aaa	p.E346K	MTIF2_ENST00000263629.4_Missense_Mutation_p.E346K|MTIF2_ENST00000403721.1_Missense_Mutation_p.E346K	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	346					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						GCTTTCAATTCTAACATTTCT	0.368000													46	80					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157665191	157665191	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:157665191C>T	ENST00000368184.3	-	8	1630	c.1339G>A	c.(1339-1341)Gga>Aga	p.G447R	FCRL3_ENST00000368186.5_Missense_Mutation_p.G447R|RP11-367J7.3_ENST00000453692.1_RNA|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	447	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GAGTAGTTTCCAGAATGTTCT	0.532000													39	146					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57850383	57850383	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:57850383G>A	ENST00000266646.2	+	2	1021	c.805G>A	c.(805-807)Gag>Aag	p.E269K	INHBE_ENST00000551553.1_3'UTR	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	269					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						ACTGCAGCCCGAGGGGTACCA	0.612000											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	79					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47098519	47098519	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:47098519G>A	ENST00000409792.3	-	15	6797	c.6755C>T	c.(6754-6756)tCc>tTc	p.S2252F		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2252	Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGCAACGCTGGAGTCTTGGTG	0.557000			"""N, F, S, Mis"""		clear cell renal carcinoma								17	47					0	0	1	0	0
ZYG11B	79699	broad.mit.edu	37	1	53236939	53236939	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:53236939C>G	ENST00000294353.6	+	3	589	c.444C>G	c.(442-444)ctC>ctG	p.L148L	ZYG11B_ENST00000443756.2_Silent_p.L148L|ZYG11B_ENST00000545132.1_Silent_p.L148L	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	148							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						CATTAACTCTCTCCCTCGAGG	0.473000													13	53					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064321	7064321	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:7064321C>G	ENST00000299481.4	+	4	1410	c.1064C>G	c.(1063-1065)tCa>tGa	p.S355*		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	355	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GTATTCAGTTCACTAAAAAGC	0.443000													28	100					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132476758	132476758	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:132476758C>G	ENST00000333577.4	+	12	2937	c.2828C>G	c.(2827-2829)tCt>tGt	p.S943C	EP400_ENST00000332482.4_Missense_Mutation_p.S870C|EP400_ENST00000330386.6_Missense_Mutation_p.S907C|EP400_ENST00000389561.2_Missense_Mutation_p.S907C|EP400_ENST00000389562.2_Missense_Mutation_p.S906C			Q96L91	EP400_HUMAN	E1A binding protein p400	943					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GCTAGCATATCTTTGACTGAT	0.443000													87	117					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576855	7576855	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:7576855G>A	ENST00000420246.2	-	9	1123	c.991C>T	c.(991-993)Cag>Tag	p.Q331*	TP53_ENST00000269305.4_Nonsense_Mutation_p.Q331*|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q331*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q331*|TP53_ENST00000445888.2_Nonsense_Mutation_p.Q331*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	331	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		Q -> H (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(23)|p.0?(8)|p.Q331fs*6(2)|p.?(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTAGTACCTGAAGGGTGAAA	0.448000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			32	20					0	0	1	0	0
MIER3	166968	broad.mit.edu	37	5	56219220	56219220	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:56219220G>A	ENST00000381226.3	-	13	1418	c.1403C>T	c.(1402-1404)tCg>tTg	p.S468L	MIER3_ENST00000381199.3_Missense_Mutation_p.S463L|SETD9_ENST00000541720.1_Intron|MIER3_ENST00000409421.1_Missense_Mutation_p.S400L|MIER3_ENST00000381213.3_Missense_Mutation_p.S462L			Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family member 3	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(2)|urinary_tract(1)	19		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		GTTTAGCTCCGAGTGATAAAA	0.408000													26	53					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11091393	11091393	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:11091393C>T	ENST00000403050.3	+	14	2919	c.2467C>T	c.(2467-2469)Ccg>Tcg	p.P823S	PHF14_ENST00000445996.2_Missense_Mutation_p.P538S	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	823							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		CAAGAAGATTCCGATAAGAAA	0.393000													29	31					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483505	59483505	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:59483505G>A	ENST00000312828.3	-	2	1291	c.192C>T	c.(190-192)ttC>ttT	p.F64F		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	64					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				GCGACACGGAGAAGCCGGGAG	0.622000													26	45					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141110549	141110549	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:141110549C>G	ENST00000389484.3	-	76	12594	c.11623G>C	c.(11623-11625)Gaa>Caa	p.E3875Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3875	EGF-like 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.E3875*(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATTTCTTTCTTGAAAATTC	0.308000										TSP Lung(27;0.18)			40	32					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110146643	110146643	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:110146643G>A	ENST00000351050.3	-	7	990	c.804C>T	c.(802-804)ctC>ctT	p.L268L		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	268					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		CCTTCTTGTTGAGAAAGAGGA	0.388000													28	29					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124341674	124341674	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:124341674C>A	ENST00000409039.3	+	36	6181	c.6156C>A	c.(6154-6156)ttC>ttA	p.F2052L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2052					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCCTCTTTTCCTTGGTTTGA	0.517000													16	49					4.7546e-09	4.85663e-09	1	1	0
SEC24C	9632	broad.mit.edu	37	10	75529189	75529189	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:75529189G>A	ENST00000339365.2	+	19	2671	c.2509G>A	c.(2509-2511)Gat>Aat	p.D837N	SEC24C_ENST00000411652.2_Missense_Mutation_p.D718N|SEC24C_ENST00000496827.1_3'UTR|SEC24C_ENST00000345254.4_Missense_Mutation_p.D837N|SEC24C_ENST00000535742.1_Missense_Mutation_p.D85N|SEC24C_ENST00000540668.1_Missense_Mutation_p.D85N	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	837					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					CCAGCTGGCTGATCTATATCG	0.562000													10	28					0	0	1	0	0
ACCS	84680	broad.mit.edu	37	11	44099468	44099468	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:44099468C>G	ENST00000263776.8	+	8	1162	c.728C>G	c.(727-729)tCt>tGt	p.S243C		NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	243							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						GAAGCTCACTCTGAGGTCTGG	0.582000													10	19					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111782458	111782458	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:111782458G>A	ENST00000452346.2	+	12	1537	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.E386K			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	512	LDL-receptor class A 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CTGCTTTGATGAAAGTGATGA	0.418000													6	205					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735850	55735850	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:55735850C>T	ENST00000312345.2	-	1	140	c.90G>A	c.(88-90)ctG>ctA	p.L30L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					CATTGCACATCAGGATCATCA	0.333000													32	46					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424883	91424883	+	Silent	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:91424883C>A	ENST00000268171.3	+	16	2439	c.2160C>A	c.(2158-2160)ctC>ctA	p.L720L		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	720					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity	p.V717fs*18(1)		breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TGGCCGGCCTCAGCTGCGCCT	0.667000													53	84					2.27781e-18	2.36561e-18	1	1	0
PLCD4	84812	broad.mit.edu	37	2	219498833	219498833	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:219498833G>A	ENST00000450993.2	+	12	1951	c.1612G>A	c.(1612-1614)Gag>Aag	p.E538K	PLCD4_ENST00000417849.1_Missense_Mutation_p.E538K|PLCD4_ENST00000432688.1_Missense_Mutation_p.E570K	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	538	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TACAGGCAATGAGTTTGTGCA	0.527000													7	4					0	0	1	0	0
MESDC1	59274	broad.mit.edu	37	15	81295006	81295006	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:81295006C>T	ENST00000267984.2	+	1	1712	c.394C>T	c.(394-396)Ctg>Ttg	p.L132L		NM_022566.2	NP_072088.1	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	132										endometrium(1)|lung(2)	3						CGCGGCCTATCTGGCCGCTGT	0.746000													9	5					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17143784	17143784	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:17143784C>T	ENST00000265970.7	-	14	2607	c.2608G>A	c.(2608-2610)Gat>Aat	p.D870N	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Missense_Mutation_p.D490N	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	870					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	CCTTTTATATCATTCTCTAGT	0.323000													19	44					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30533948	30533948	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:30533948C>T	ENST00000358365.3	+	17	1663	c.1436C>T	c.(1435-1437)tCg>tTg	p.S479L	RHOT1_ENST00000581094.1_Missense_Mutation_p.S479L|RHOT1_ENST00000583994.1_Missense_Mutation_p.S352L|RHOT1_ENST00000545287.2_Missense_Mutation_p.S479L|RHOT1_ENST00000354266.3_Missense_Mutation_p.S458L|RHOT1_ENST00000333942.6_Missense_Mutation_p.S479L|RHOT1_ENST00000394692.2_Missense_Mutation_p.S479L	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	479	Miro 2.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				ATCTCAGAATCGGAATTTCTA	0.308000													28	77					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47142964	47142964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:47142964G>A	ENST00000409792.3	-	8	5041	c.4999C>T	c.(4999-5001)Cag>Tag	p.Q1667*		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1667	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.Q1667*(1)|p.Q1164*(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTCTGGAACTGATAGTCAAAC	0.373000			"""N, F, S, Mis"""		clear cell renal carcinoma								70	147					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150768673	150768673	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:150768673C>T	ENST00000485713.1	+	14	3212	c.2172C>T	c.(2170-2172)atC>atT	p.I724I	SLC4A2_ENST00000461735.1_Silent_p.I710I|SLC4A2_ENST00000413384.2_Silent_p.I724I|SLC4A2_ENST00000310317.5_Silent_p.I642I|SLC4A2_ENST00000392826.2_Silent_p.I715I	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	724	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTCCTGCCATCACCTTTGGGG	0.637000													44	29					0	0	1	0	0
GPR107	57720	broad.mit.edu	37	9	132854600	132854600	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:132854600C>T	ENST00000372406.1	+	9	1310	c.803C>T	c.(802-804)tCa>tTa	p.S268L	GPR107_ENST00000347136.6_Missense_Mutation_p.S268L|GPR107_ENST00000372410.3_Missense_Mutation_p.S268L	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	268						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TTATACATCTCAATGGCCTTT	0.388000													18	46					0	0	1	0	0
SUZ12	23512	broad.mit.edu	37	17	30302570	30302570	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:30302570C>T	ENST00000322652.5	+	7	890	c.661C>T	c.(661-663)Caa>Taa	p.Q221*	SUZ12_ENST00000580398.1_Nonsense_Mutation_p.Q198*	NM_015355.2	NP_056170.2	Q15022	SUZ12_HUMAN	SUZ12 polycomb repressive complex 2 subunit	221					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		SSH2/SUZ12(2)|JAZF1/SUZ12(133)	breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(5)|skin(1)	21		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TGACCTCAATCAAACAAAACC	0.383000			T	JAZF1	endometrial stromal tumours								25	122					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241530381	241530381	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:241530381G>C	ENST00000391984.2	+	3	619	c.423G>C	c.(421-423)caG>caC	p.Q141H	CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000391982.2_Missense_Mutation_p.Q141H|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000404753.3_Missense_Mutation_p.Q141H|CAPN10_ENST00000354082.4_Missense_Mutation_p.Q141H	NM_023083.3	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10	141	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		CCCGCTGCCAGAGGGAGGATG	0.622000													22	22					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1251879	1251879	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:1251879C>T	ENST00000300952.2	+	4	878	c.363C>T	c.(361-363)ctC>ctT	p.L121L	MIDN_ENST00000591446.2_Silent_p.L121L	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	121						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCAAGCTCTCGAGAGTCTCA	0.637000													6	23					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10444949	10444949	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:10444949G>A	ENST00000326756.3	-	3	3442	c.3004C>T	c.(3004-3006)Caa>Taa	p.Q1002*		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	1002					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						CTTTTAATTTGACTGGCTTCT	0.413000													11	44					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67980504	67980504	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:67980504C>T	ENST00000422611.2	-	17	2319	c.2280G>A	c.(2278-2280)gtG>gtA	p.V760V	SLC12A4_ENST00000576616.1_Silent_p.V758V|SLC12A4_ENST00000537830.2_Silent_p.V752V|SLC12A4_ENST00000316341.3_Silent_p.V758V|SLC12A4_ENST00000572037.1_Silent_p.V710V|SLC12A4_ENST00000541864.2_Silent_p.V727V|SLC12A4_ENST00000338335.3_Intron	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	758					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGAAGCCCTTCACCTTCTCAA	0.622000													11	75					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30783276	30783276	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:30783276C>T	ENST00000324685.6	+	18	3144	c.2709C>T	c.(2707-2709)ttC>ttT	p.F903F	RNF40_ENST00000567365.1_3'UTR|RNF40_ENST00000357890.5_Silent_p.F803F|RNF40_ENST00000402121.3_Silent_p.F595F|RNF40_ENST00000563683.1_Silent_p.F863F	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	903					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			AAGAGAGCTTCAACCTCAAGA	0.652000													10	51					0	0	1	0	0
SSBP3	23648	broad.mit.edu	37	1	54692813	54692813	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:54692813C>A	ENST00000371320.3	-	18	1568	c.1158G>T	c.(1156-1158)atG>atT	p.M386I	SSBP3_ENST00000326956.7_5'UTR|SSBP3_ENST00000357475.4_Missense_Mutation_p.M366I|SSBP3_ENST00000417664.2_Missense_Mutation_p.M276I|SSBP3_ENST00000371319.3_Missense_Mutation_p.M359I	NM_145716.2	NP_663768.1	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	11						ATCACACACTCATCGTCATGC	0.567000													48	151					1.30916e-28	1.36658e-28	1	1	0
LHX2	9355	broad.mit.edu	37	9	126774727	126774727	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:126774727G>A	ENST00000373615.4	+	1	839	c.100G>A	c.(100-102)Gac>Aac	p.D34N		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	34						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CTCCGCCATCGACCGCGGCGA	0.701000													5	2					0	0	1	0	0
HPR	3250	broad.mit.edu	37	16	72107850	72107850	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:72107850C>G	ENST00000540303.2	+	2	97	c.65C>G	c.(64-66)tCa>tGa	p.S22*	HPR_ENST00000356967.5_Nonsense_Mutation_p.S22*|HPR_ENST00000228226.8_Nonsense_Mutation_p.S59*|HPR_ENST00000561690.1_Nonsense_Mutation_p.S22*	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	22					proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				GCACTGTACTCAGGCAATGAT	0.537000													15	80					0	0	1	0	0
NDUFA1	4694	broad.mit.edu	37	X	119005903	119005903	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:119005903C>T	ENST00000371437.4	+	1	454	c.29C>T	c.(28-30)tCc>tTc	p.S10F		NM_004541.3	NP_004532.1	O15239	NDUA1_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	10					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|large_intestine(2)|stomach(1)	5					NADH(DB00157)	CCCGGACTCTCCGTCATGGGC	0.592000													88	33					0	0	1	0	0
C1orf52	148423	broad.mit.edu	37	1	85724285	85724285	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:85724285C>T	ENST00000471115.1	-	2	405	c.397G>A	c.(397-399)Gag>Aag	p.E133K	C1orf52_ENST00000344356.5_Missense_Mutation_p.E133K|C1orf52_ENST00000294661.4_5'UTR	NM_198077.3	NP_932343.1	Q8N6N3	CA052_HUMAN	chromosome 1 open reading frame 52	133										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)	10				all cancers(265;0.0105)|Epithelial(280;0.0293)		CCATTGTCCTCATATATGTTA	0.458000													67	88					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233394809	233394809	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:233394809C>T	ENST00000536614.1	+	6	698	c.670C>T	c.(670-672)Ctc>Ttc	p.L224F	CHRND_ENST00000258385.3_Silent_p.I260I|CHRND_ENST00000457943.2_Intron|CHRND_ENST00000543200.1_Silent_p.I245I			Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	0					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GCGTGCTCATCTCCTTCATGG	0.622000													17	86					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100234723	100234723	+	Silent	SNP	C	C	T	rs144270321		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:100234723C>T	ENST00000355295.4	+	10	2185	c.1890C>T	c.(1888-1890)atC>atT	p.I630I	TDRD7_ENST00000422139.2_Silent_p.I556I|TDRD7_ENST00000540902.1_5'UTR	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	630					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				ATATCAATATCAATGCCACCT	0.408000													38	65					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40646305	40646305	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:40646305G>C	ENST00000342449.3	-	13	1317	c.1239C>G	c.(1237-1239)atC>atG	p.I413M	BRWD1_ENST00000333229.2_Missense_Mutation_p.I413M|BRWD1_ENST00000380800.3_Missense_Mutation_p.I413M	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CTTACCCTGAGATTCTGGTAG	0.433000													27	27					0	0	1	0	0
CCNG2	901	broad.mit.edu	37	4	78087038	78087038	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:78087038C>T	ENST00000316355.5	+	8	1352	c.996C>T	c.(994-996)ttC>ttT	p.F332F	CCNG2_ENST00000502280.1_Silent_p.F332F|CCNG2_ENST00000497512.1_Intron|CCNG2_ENST00000354403.5_Intron|CCNG2_ENST00000395640.1_Silent_p.F332F	NM_004354.2	NP_004345.1	Q16589	CCNG2_HUMAN	cyclin G2	332					cell cycle checkpoint|cell division|mitosis	cytoplasm				breast(1)|kidney(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						CCTTCTTTTTCAACTTCAAAG	0.398000													9	28					0	0	1	0	0
LAIR2	3904	broad.mit.edu	37	19	55019130	55019130	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:55019130C>T	ENST00000301202.2	+	3	217	c.95C>T	c.(94-96)tCg>tTg	p.S32L	LAIR2_ENST00000351841.2_Missense_Mutation_p.S32L	NM_002288.4	NP_002279.2	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like receptor 2	32	Ig-like C2-type.					extracellular region	receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)	18	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		CCCTCCATCTCGGCTGAGCCA	0.577000													81	237					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58134449	58134449	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:58134449C>T	ENST00000357272.4	+	36	6126	c.5961C>T	c.(5959-5961)aaC>aaT	p.N1987N	FLNB_ENST00000419752.2_Silent_p.N1807N|FLNB_ENST00000295956.4_Silent_p.N1987N|FLNB_ENST00000348383.5_Silent_p.N1987N|FLNB_ENST00000493452.1_Silent_p.N1794N|FLNB_ENST00000358537.3_Silent_p.N1963N|FLNB_ENST00000490882.1_Silent_p.N2018N|FLNB_ENST00000429972.2_Silent_p.N1976N			O75369	FLNB_HUMAN	filamin B, beta	1987	Interaction with the cytoplasmic tail of GP1BA.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ATGTGGCCAACAGCCCCGTGT	0.577000													20	60					0	0	1	0	0
PANK2	80025	broad.mit.edu	37	20	3870272	3870272	+	Silent	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:3870272C>A	ENST00000316562.4	+	1	531	c.525C>A	c.(523-525)gtC>gtA	p.V175V	PANK2_ENST00000497424.1_Intron|PANK2_ENST00000610179.1_Silent_p.V52V	NM_153638.2	NP_705902.2	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	175					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TGCCCGCGGTCGGGGCCTCGG	0.756000													11	10					6.40141e-05	6.46479e-05	1	1	0
ZNF700	90592	broad.mit.edu	37	19	12060204	12060204	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:12060204C>T	ENST00000482090.1	+	3	1729	c.1311C>T	c.(1309-1311)ttC>ttT	p.F437F	ZNF763_ENST00000590798.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000538752.1_Intron|ZNF700_ENST00000254321.5_Silent_p.F455F|ZNF763_ENST00000591944.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	455					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F455F(1)	ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						GGAAAGCCTTCAGATCTACCT	0.488000													45	67					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86303407	86303407	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:86303407C>A	ENST00000314673.3	-	1	206	c.30G>T	c.(28-30)caG>caT	p.Q10H	RP11-321N4.5_ENST00000503906.1_Intron|SNX14_ENST00000505648.1_Intron|SNX14_ENST00000369627.2_Missense_Mutation_p.Q10H|SNX14_ENST00000346348.3_Missense_Mutation_p.Q10H|SNX14_ENST00000513865.1_Missense_Mutation_p.Q10H	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	10					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GCTTCAGCTTCTGCCCCATCG	0.667000													11	19					1.61879e-10	1.65827e-10	1	1	0
FAT1	2195	broad.mit.edu	37	4	187521067	187521067	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:187521067G>A	ENST00000441802.2	-	22	12297	c.12088C>T	c.(12088-12090)Ccg>Tcg	p.P4030S		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4030	EGF-like 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCAGGTGACGGATTGCAAACG	0.507000										HNSCC(5;0.00058)			19	48					0	0	1	0	0
DFFA	1676	broad.mit.edu	37	1	10532399	10532399	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:10532399G>C	ENST00000377038.3	-	1	184	c.117C>G	c.(115-117)ctC>ctG	p.L39L	DFFA_ENST00000377036.2_Silent_p.L39L	NM_004401.2	NP_004392.1	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha polypeptide	39	CIDE-N.				DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding			large_intestine(3)|lung(2)	5	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TCAGGTCTTCGAGGCAGGAGG	0.706000													10	71					0	0	1	0	0
SCARB2	950	broad.mit.edu	37	4	77082892	77082892	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:77082892C>T	ENST00000264896.2	-	12	1760	c.1411G>A	c.(1411-1413)Gaa>Aaa	p.E471K	SCARB2_ENST00000452464.2_Missense_Mutation_p.E328K	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	471					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			GGTGCTCTTTCATCCGCTGTT	0.498000													9	51					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105463492	105463492	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:105463492C>T	ENST00000351513.2	-	2	537	c.405G>A	c.(403-405)gtG>gtA	p.V135V		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	135					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCCACCACGTCACTGCCACAT	0.517000													20	67					0	0	1	0	0
TMEM109	79073	broad.mit.edu	37	11	60689292	60689292	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:60689292G>C	ENST00000227525.3	+	4	790	c.387G>C	c.(385-387)caG>caC	p.Q129H	TMEM109_ENST00000536171.1_Missense_Mutation_p.Q129H|RP11-881M11.4_ENST00000543907.1_RNA	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	129						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						GCCAGGTCCAGACCTTCCTGC	0.642000													50	77					0	0	1	0	0
TSEN2	80746	broad.mit.edu	37	3	12545071	12545071	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:12545071G>C	ENST00000444864.1	+	5	1006	c.619G>C	c.(619-621)Gag>Cag	p.E207Q	TSEN2_ENST00000314571.7_Missense_Mutation_p.E207Q|TSEN2_ENST00000383797.5_Missense_Mutation_p.E207Q|TSEN2_ENST00000454502.2_Intron|TSEN2_ENST00000402228.3_Missense_Mutation_p.E207Q|TSEN2_ENST00000284995.6_Missense_Mutation_p.E207Q|TSEN2_ENST00000415684.1_Missense_Mutation_p.E207Q	NM_001145395.1	NP_001138867.1	Q8NCE0	SEN2_HUMAN	TSEN2 tRNA splicing endonuclease subunit	207					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)	19						AGAGAGCTTTGAGAAAAGCGT	0.572000													12	33					0	0	1	0	0
TMOD3	29766	broad.mit.edu	37	15	52186074	52186074	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:52186074G>C	ENST00000308580.7	+	6	840	c.559G>C	c.(559-561)Gaa>Caa	p.E187Q	RP11-56B16.5_ENST00000558142.1_RNA|TMOD3_ENST00000544199.1_Missense_Mutation_p.E187Q	NM_014547.4	NP_055362.1	Q9NYL9	TMOD3_HUMAN	tropomodulin 3 (ubiquitous)	187						cytoplasm|cytoskeleton	actin binding|tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|stomach(1)	14				all cancers(107;0.00194)		AACCAATGTAGAAGAGAGTTT	0.353000													52	45					0	0	1	0	0
ACOX3	8310	broad.mit.edu	37	4	8383294	8383294	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:8383294G>A	ENST00000356406.5	-	14	1655	c.1578C>T	c.(1576-1578)ctC>ctT	p.L526L	ACOX3_ENST00000503233.1_Silent_p.L526L|ACOX3_ENST00000413009.2_Silent_p.L526L	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	526					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						AAGTCTCTCGGAGCAGGTAGC	0.408000													12	59					0	0	1	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154527951	154527951	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:154527951G>A	ENST00000292211.4	-	3	569	c.490C>T	c.(490-492)Cag>Tag	p.Q164*	UBE2Q1_ENST00000497453.1_5'UTR	NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	164							ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCTGGATGCTGAGGGAGGTTA	0.547000													25	125					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906456	5906456	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:5906456G>A	ENST00000316987.2	+	1	956	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E312*(1)		autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTACAGAAAGAATAATTCTG	0.363000													9	28					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760364	20760364	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:20760364C>T	ENST00000400451.2	+	5	1555	c.1041C>T	c.(1039-1041)ctC>ctT	p.L347L	ZNF74_ENST00000356671.5_Silent_p.L347L|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000405993.1_Silent_p.L315L|ZNF74_ENST00000403682.3_3'UTR	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	347					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCTCGCTGCTCAGCATGCACC	0.672000													25	48					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802526	24802526	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:24802526G>A	ENST00000395799.3	+	6	2692	c.2563G>A	c.(2563-2565)Gat>Aat	p.D855N	TNRC6A_ENST00000315183.7_Missense_Mutation_p.D855N	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	855	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TTCTGCCAGTGATAACTGGGG	0.478000													16	27					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135333283	135333283	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:135333283C>T	ENST00000285968.6	+	43	6044	c.6018C>T	c.(6016-6018)ctC>ctT	p.L2006L		NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	2006					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.L2006L(1)		breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TCCGTGGCCTCTTGAGGATAT	0.383000													40	39					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15303689	15303689	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:15303689G>A	ENST00000383791.3	-	5	823	c.603C>T	c.(601-603)ctC>ctT	p.L201L	SH3BP5_ENST00000426925.1_Silent_p.L44L|SH3BP5_ENST00000408919.3_Silent_p.L44L|SH3BP5-AS1_ENST00000420195.1_RNA|SH3BP5_ENST00000253688.5_Silent_p.L44L	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	201					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						TGGCTCTCTTGAGTTTCTTCT	0.577000													29	61					0	0	1	0	0
IL4I1	259307	broad.mit.edu	37	19	50394272	50394272	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:50394272G>A	ENST00000595948.1	-	9	1415	c.795C>T	c.(793-795)ttC>ttT	p.F265F	IL4I1_ENST00000341114.3_Silent_p.F265F|IL4I1_ENST00000391826.2_Silent_p.F243F	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	243						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		GGGCCTCGGCGAAGCTGAGAT	0.667000													35	53					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31911913	31911913	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31911913G>C	ENST00000456570.1	+	12	1408	c.1353G>C	c.(1351-1353)gaG>gaC	p.E451D	C2_ENST00000468407.1_3'UTR|C2_ENST00000442278.2_Splice_Site_p.E472D|C2_ENST00000299367.5_Splice_Site_p.E604D|C2_ENST00000469372.1_Splice_Site_p.E358D|CFB_ENST00000477310.1_Splice_Site_p.E375D|C2_ENST00000452323.2_Splice_Site_p.E390D|CFB_ENST00000556679.1_Splice_Site_p.E451D			P00751	CFAB_HUMAN	complement factor B	619	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGACTATAGAGAATGAACTGC	0.483000													17	33					0	0	1	0	0
MIER3	166968	broad.mit.edu	37	5	56231255	56231255	+	Splice_Site	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:56231255C>G	ENST00000381226.3	-	7	625	c.610G>C	c.(610-612)Gta>Cta	p.V204L	MIER3_ENST00000381199.3_Splice_Site_p.V199L|MIER3_ENST00000409421.1_Splice_Site_p.V136L|MIER3_ENST00000381213.3_Splice_Site_p.V199L			Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family member 3	199	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(2)|urinary_tract(1)	19		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		CTTTCCTTACCTTTCTCATTA	0.338000													40	69					0	0	1	0	0
RPL13	6137	broad.mit.edu	37	16	89628100	89628100	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:89628100C>T	ENST00000393099.3	+	3	610	c.361C>T	c.(361-363)Cgc>Tgc	p.R121C	RPL13_ENST00000311528.5_Missense_Mutation_p.R121C|RPL13_ENST00000452368.3_Intron|RPL13_ENST00000567815.1_Missense_Mutation_p.R121C	NM_033251.2	NP_150254.1	P26373	RL13_HUMAN	ribosomal protein L13	121					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic ribosome	protein binding|RNA binding|structural constituent of ribosome			lung(3)|skin(1)|upper_aerodigestive_tract(2)	6		all_hematologic(23;0.0748)		all cancers(4;1.15e-07)|OV - Ovarian serous cystadenocarcinoma(4;7.8e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0139)		GAAGGAGTACCGCTCCAAACT	0.627000													18	35					0	0	1	0	0
MRPL16	54948	broad.mit.edu	37	11	59573993	59573993	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:59573993G>C	ENST00000300151.4	-	4	796	c.583C>G	c.(583-585)Cta>Gta	p.L195V		NM_017840.3	NP_060310.1	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16	195							rRNA binding			central_nervous_system(1)|endometrium(1)|liver(1)|lung(8)	11						ATCTTCTCTAGAGTCCCGCGG	0.512000													4	122					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50381464	50381464	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:50381464C>T	ENST00000221543.5	+	2	385	c.86C>T	c.(85-87)tCt>tTt	p.S29F	TBC1D17_ENST00000598789.1_3'UTR|TBC1D17_ENST00000535102.2_Intron|AKT1S1_ENST00000482622.1_5'UTR	NM_024682.2	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	29						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GACCGAGACTCTCTCATCGCT	0.637000													9	7					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106046199	106046199	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:106046199G>T	ENST00000357242.5	+	1	290	c.116G>T	c.(115-117)gGa>gTa	p.G39V	TBC1D8B_ENST00000310452.2_Missense_Mutation_p.G39V|TBC1D8B_ENST00000276175.3_Missense_Mutation_p.G39V|TBC1D8B_ENST00000481617.2_Missense_Mutation_p.G39V	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	39						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GAGGAAGGCGGAGGGGGGCTC	0.577000													19	8					1.01871e-10	1.04431e-10	1	1	0
MRPS26	64949	broad.mit.edu	37	20	3027133	3027133	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:3027133C>T	ENST00000380325.3	+	2	451	c.327C>T	c.(325-327)aaC>aaT	p.N109N		NM_030811.3	NP_110438.1	Q9BYN8	RT26_HUMAN	mitochondrial ribosomal protein S26	109					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				kidney(1)|lung(1)	2						TGGCCTGGAACCAGGCGGAGA	0.771000													4	14					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7229527	7229527	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:7229527C>T	ENST00000379938.2	+	10	1732	c.1195C>T	c.(1195-1197)Cag>Tag	p.Q399*	RREB1_ENST00000334984.6_Nonsense_Mutation_p.Q399*|RREB1_ENST00000349384.6_Nonsense_Mutation_p.Q399*|RREB1_ENST00000379933.3_Nonsense_Mutation_p.Q399*	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	399					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ACTCAAGTGTCAGCTACCTCA	0.617000													15	38					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89148330	89148330	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:89148330G>C	ENST00000554922.1	-	21	3276	c.3028C>G	c.(3028-3030)Ctg>Gtg	p.L1010V	EML5_ENST00000352093.5_Missense_Mutation_p.L972V|EML5_ENST00000380664.5_Missense_Mutation_p.L1010V	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1010						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAGATGGGCAGATAAGGGTGT	0.408000													32	72					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204214819	204214819	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:204214819G>A	ENST00000272203.3	-	14	2272	c.1956C>T	c.(1954-1956)atC>atT	p.I652I	PLEKHA6_ENST00000414478.1_Silent_p.I672I	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	652										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGATCCTCCAGATCTCCTTTT	0.587000													25	81					0	0	1	0	0
FOS	2353	broad.mit.edu	37	14	75746726	75746726	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:75746726C>T	ENST00000303562.4	+	2	497	c.288C>T	c.(286-288)ttC>ttT	p.F96F	FOS_ENST00000555686.1_5'UTR|FOS_ENST00000555242.1_Silent_p.F96F|FOS_ENST00000535987.1_Silent_p.F96F|FOS_ENST00000554617.1_Silent_p.F96F	NM_005252.3	NP_005243.1	P01100	FOS_HUMAN	FBJ murine osteosarcoma viral oncogene homolog	96					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CTCACCCTTTCGGAGTCCCCG	0.682000													33	63					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31473663	31473663	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:31473663C>T	ENST00000457010.2	+	3	1496	c.795C>T	c.(793-795)ctC>ctT	p.L265L	ARMC5_ENST00000408912.3_Silent_p.L360L|ARMC5_ENST00000563544.1_Silent_p.L265L|ARMC5_ENST00000538189.1_Silent_p.L297L|ARMC5_ENST00000412665.2_Intron|ARMC5_ENST00000268314.4_Silent_p.L265L	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	265							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						TCCTGGAACTCAGCCGAGGCT	0.682000													8	42					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100286458	100286458	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:100286458G>A	ENST00000395996.1	+	18	2659	c.2548G>A	c.(2548-2550)Gag>Aag	p.E850K	VPS13B_ENST00000357162.2_Missense_Mutation_p.E850K|VPS13B_ENST00000358544.2_Missense_Mutation_p.E850K			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	850					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCCAACTCTTGAGGGCTCAAT	0.388000													43	86					0	0	1	0	0
ZNF345	25850	broad.mit.edu	37	19	37369175	37369175	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:37369175C>T	ENST00000529555.1	+	2	2231	c.1443C>T	c.(1441-1443)ctC>ctT	p.L481L	ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000589046.1_Silent_p.L481L|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000420450.1_Silent_p.L481L			Q14585	ZN345_HUMAN	zinc finger protein 345	481					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTAAGAAACTCTGCGAATTGG	0.338000													45	80					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129854066	129854066	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:129854066C>G	ENST00000373425.3	-	4	1782	c.1165G>C	c.(1165-1167)Gag>Cag	p.E389Q	RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000394022.3_Intron|ANGPTL2_ENST00000373417.1_Missense_Mutation_p.E87Q|RALGPS1_ENST00000373436.1_Intron|RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000259351.5_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	389	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						TACTCGCTCTCAGGTTCCAGG	0.562000													10	336					0	0	1	0	0
ZNF136	7695	broad.mit.edu	37	19	12298524	12298524	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:12298524G>T	ENST00000343979.4	+	4	1471	c.1331G>T	c.(1330-1332)gGa>gTa	p.G444V	ZNF136_ENST00000398616.2_Missense_Mutation_p.G378V	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	444					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						ACTCATACTGGAGAGAAACCC	0.383000													15	31					6.31663e-08	6.43377e-08	1	1	0
UGT2B15	7366	broad.mit.edu	37	4	69512827	69512827	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:69512827C>G	ENST00000338206.5	-	6	1597	c.1588G>C	c.(1588-1590)Gat>Cat	p.D530H		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	530					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										TATAACTAATCTCTTTTCTTC	0.388000													33	87					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10220324	10220324	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10220324C>T	ENST00000428358.1	+	6	703	c.531C>T	c.(529-531)atC>atT	p.I177I	PPAN_ENST00000253107.7_Silent_p.I177I|PPAN_ENST00000556468.1_Silent_p.I177I|PPAN_ENST00000393793.1_Silent_p.I124I|PPAN-P2RY11_ENST00000393796.4_Silent_p.I177I	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		177	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGAACACCATCAAGCGCTGCC	0.587000													169	350					0	0	1	0	0
GNAT1	2779	broad.mit.edu	37	3	50231306	50231306	+	Silent	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:50231306C>A	ENST00000232461.3	+	5	684	c.570C>A	c.(568-570)ctC>ctA	p.L190L	GNAT1_ENST00000433068.1_Silent_p.L190L|GNAT1_ENST00000481246.1_3'UTR	NM_144499.2	NP_653082.1	P11488	GNAT1_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	190					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TCAAGGATCTCAACTTCCGGT	0.652000													6	125					0.0215528	0.0216133	1	1	0
TSSK4	283629	broad.mit.edu	37	14	24675316	24675316	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:24675316G>A	ENST00000339917.5	+	1	391	c.187G>A	c.(187-189)Gat>Aat	p.D63N	TSSK4_ENST00000287913.6_Missense_Mutation_p.D63N|TSSK4_ENST00000556621.1_Intron|TSSK4_ENST00000428351.2_Missense_Mutation_p.D63N|TM9SF1_ENST00000530611.1_Intron|TM9SF1_ENST00000556387.1_Intron	NM_001184739.1|NM_174944.3	NP_001171668.1|NP_777604.2	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	63	Protein kinase.				cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8				GBM - Glioblastoma multiforme(265;0.018)		GAAGGCCTCTGATGACTATCT	0.493000													40	95					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29818706	29818706	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:29818706G>C	ENST00000219782.6	+	2	706	c.600G>C	c.(598-600)aaG>aaC	p.K200N	AC009133.15_ENST00000566537.1_RNA|MAZ_ENST00000545521.1_Missense_Mutation_p.K177N|MAZ_ENST00000563402.1_Intron|MAZ_ENST00000322945.6_Missense_Mutation_p.K200N|MAZ_ENST00000562337.1_Intron|MAZ_ENST00000566906.2_Intron	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	200					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						AGGAGTTCAAGAACGGCTACA	0.637000													10	32					0	0	1	0	0
FAM117A	81558	broad.mit.edu	37	17	47809986	47809986	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:47809986G>A	ENST00000240364.2	-	2	372	c.293C>T	c.(292-294)tCc>tTc	p.S98F	FAM117A_ENST00000514018.1_5'UTR|FAM117A_ENST00000513602.1_5'UTR	NM_030802.3	NP_110429.1	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	98										haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	17						CAGAAGGTAGGAGCTGAGGAT	0.592000													15	30					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138333772	138333772	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:138333772G>A	ENST00000421622.1	-	4	493	c.285C>T	c.(283-285)ctC>ctT	p.L95L	SVOPL_ENST00000419765.3_Silent_p.L215L|SVOPL_ENST00000288513.5_Silent_p.L63L|SVOPL_ENST00000436657.1_Silent_p.L63L			Q8N434	SVOPL_HUMAN	SVOP-like	215						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						AGGCCACGATGAGGATGATGC	0.587000													23	21					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	145142076	145142076	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:145142076C>T	ENST00000367545.3	+	65	9416	c.9416C>T	c.(9415-9417)tCg>tTg	p.S3139L	UTRN_ENST00000367526.4_Missense_Mutation_p.S694L	NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	3139	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AAGTTCAGGTCGAAGAAGTAC	0.388000													19	18					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	37903995	37903995	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:37903995C>T	ENST00000261439.4	+	2	634	c.279C>T	c.(277-279)atC>atT	p.I93I	TBC1D1_ENST00000508802.1_Silent_p.I93I|TBC1D1_ENST00000402522.1_Silent_p.I93I	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	93						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						ATTCCAGCATCTTTGAGTGCA	0.498000													33	79					0	0	1	0	0
FADD	8772	broad.mit.edu	37	11	70052340	70052340	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:70052340G>A	ENST00000301838.4	+	2	685	c.388G>A	c.(388-390)Gag>Aag	p.E130K		NM_003824.3	NP_003815.1	Q13158	FADD_HUMAN	Fas (TNFRSF6)-associated via death domain	130	Death.				activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			endometrium(1)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(2)	9	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CGACAGCATCGAGGACAGATA	0.532000													6	96					0	0	1	0	0
PSMC6	5706	broad.mit.edu	37	14	53180677	53180677	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:53180677G>A	ENST00000445930.2	+	7	568	c.562G>A	c.(562-564)Gga>Aga	p.G188R	PSMC6_ENST00000606149.1_Missense_Mutation_p.G174R			P62333	PRS10_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 6	174					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	19	Breast(41;0.176)					TTTGTTATATGGACCACCAGG	0.284000													28	49					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2851465	2851465	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:2851465G>C	ENST00000334241.4	+	3	268		c.e3-1		AC006130.3_ENST00000589365.1_RNA|ZNF555_ENST00000591539.1_Splice_Site	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTGGTTTCAGATGATGAAAC	0.378000													19	34					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205350891	205350891	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:205350891C>G	ENST00000367153.4	-	6	543	c.441G>C	c.(439-441)tgG>tgC	p.W147C	LEMD1_ENST00000367154.1_Missense_Mutation_p.G100A|LEMD1-AS1_ENST00000447832.1_RNA|LEMD1_ENST00000367152.1_Missense_Mutation_p.W106C|LEMD1_ENST00000391936.2_Missense_Mutation_p.G100A|LEMD1_ENST00000367151.2_Missense_Mutation_p.W106C|LEMD1_ENST00000367149.3_Missense_Mutation_p.G59A|LEMD1_ENST00000476884.1_5'UTR	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	147						integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			CTTCTTCTCTCCAGCTCTCGA	0.483000													33	155					0	0	1	0	0
CUEDC2	79004	broad.mit.edu	37	10	104184490	104184490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:104184490G>A	ENST00000369937.4	-	3	279	c.134C>T	c.(133-135)tCg>tTg	p.S45L		NM_024040.2	NP_076945.2	Q9H467	CUED2_HUMAN	CUE domain containing 2	45						cytoplasm|nucleus	protein binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TGATGGGCCCGAGGGGCCCAG	0.587000													42	36					0	0	1	0	0
COX7B2	170712	broad.mit.edu	37	4	46737063	46737063	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:46737063G>C	ENST00000396533.1	-	4	397	c.147C>G	c.(145-147)ttC>ttG	p.F49L	COX7B2_ENST00000355591.3_Missense_Mutation_p.F49L|COX7B2_ENST00000302930.5_Missense_Mutation_p.F49L|COX7B2_ENST00000543208.1_Missense_Mutation_p.F48L			Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2	49						integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			large_intestine(1)|lung(4)	5						TAGCAACACAGAAAGCAGTTC	0.428000													20	63					0	0	1	0	0
NR3C1	2908	broad.mit.edu	37	5	142780067	142780067	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:142780067G>A	ENST00000343796.2	-	2	1331	c.338C>T	c.(337-339)tCc>tTc	p.S113F	NR3C1_ENST00000416954.2_Intron|NR3C1_ENST00000394466.2_Missense_Mutation_p.S113F|NR3C1_ENST00000415690.2_Missense_Mutation_p.S113F|NR3C1_ENST00000424646.2_Missense_Mutation_p.S113F|NR3C1_ENST00000394464.2_Missense_Mutation_p.S113F|NR3C1_ENST00000503201.1_Missense_Mutation_p.S113F|NR3C1_ENST00000231509.3_Missense_Mutation_p.S113F|NR3C1_ENST00000504572.1_Missense_Mutation_p.S113F	NM_001018074.1|NM_001018075.1|NM_001018077.1	NP_001018084.1|NP_001018085.1|NP_001018087.1	P04150	GCR_HUMAN	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	113	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	35		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TTCCCCCGAGGAAAGGCTGAT	0.473000													67	101					0	0	1	0	0
USP16	10600	broad.mit.edu	37	21	30419526	30419526	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:30419526C>T	ENST00000334352.4	+	15	2126	c.1895C>T	c.(1894-1896)tCa>tTa	p.S632L	USP16_ENST00000535828.1_Missense_Mutation_p.S261L|USP16_ENST00000399976.2_Missense_Mutation_p.S632L|USP16_ENST00000399975.3_Missense_Mutation_p.S631L	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	632					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						GATGAGTGTTCAATCCAACAT	0.398000													37	41					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15820739	15820739	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:15820739C>G	ENST00000452625.2	-	29	3932	c.3845G>C	c.(3844-3846)cGg>cCg	p.R1282P	MYH11_ENST00000576790.2_Missense_Mutation_p.R1275P|MYH11_ENST00000300036.5_Missense_Mutation_p.R1275P|MYH11_ENST00000396324.3_Missense_Mutation_p.R1282P|AF001548.5_ENST00000574212.1_RNA	NM_001040113.1	NP_001035202.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1275					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GAGCTCCGCCCGGGCCCGCTC	0.647000			T	CBFB	AML								30	104					0	0	1	0	0
SENP3	26168	broad.mit.edu	37	17	7466472	7466472	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:7466472C>T	ENST00000321337.7	+	2	399	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S	SENP3_ENST00000578868.1_3'UTR|SENP3_ENST00000429205.2_Missense_Mutation_p.P27S	NM_015670.5	NP_056485.2	Q9H4L4	SENP3_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 3	27	Pro-rich.				proteolysis	MLL1 complex|nucleolus	cysteine-type peptidase activity			central_nervous_system(1)|ovary(1)	2		Prostate(122;0.157)				TTACTCAAGTCCCAGGCGGGA	0.607000													12	3					0	0	1	0	0
UHRF2	115426	broad.mit.edu	37	9	6460580	6460580	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:6460580G>C	ENST00000276893.5	+	4	820	c.652G>C	c.(652-654)Gaa>Caa	p.E218Q		NM_152896.2	NP_690856.1	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	218	Interaction with PCNP.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)	17		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		CAGATACCCAGAAAGCGGTAC	0.358000													20	42					0	0	1	0	0
ENDOU	8909	broad.mit.edu	37	12	48106362	48106362	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:48106362G>C	ENST00000422538.3	-	8	1031	c.909C>G	c.(907-909)atC>atG	p.I303M	RP1-197B17.3_ENST00000547799.1_lincRNA|ENDOU_ENST00000545824.2_Missense_Mutation_p.I240M|ENDOU_ENST00000542202.1_Missense_Mutation_p.I69M|ENDOU_ENST00000229003.3_Missense_Mutation_p.I262M	NM_001172439.1	NP_001165910.1	P21128	ENDOU_HUMAN	endonuclease, polyU-specific	303					female pregnancy|immune response|proteolysis	cytoplasm|extracellular space|plasma membrane	endoribonuclease activity|growth factor activity|manganese ion binding|polysaccharide binding|RNA binding|scavenger receptor activity|serine-type peptidase activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(3)|pancreas(1)|stomach(1)	14						GGTAGAAGCGGATCCAGTTAT	0.493000													15	27					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655962	19655962	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19655962G>A	ENST00000586018.1	+	8	2728	c.2626G>A	c.(2626-2628)Gac>Aac	p.D876N	CILP2_ENST00000291495.5_Missense_Mutation_p.D870N			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	870						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CAGGCCAGGTGACCCCGCCGA	0.692000													22	43					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57576803	57576803	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:57576803C>T	ENST00000524630.1	+	14	2795	c.2282C>T	c.(2281-2283)tCt>tTt	p.S761F	CTNND1_ENST00000361391.6_Missense_Mutation_p.S761F|CTNND1_ENST00000358694.6_Missense_Mutation_p.S761F|CTNND1_ENST00000532245.1_Missense_Mutation_p.S660F|CTNND1_ENST00000426142.2_Missense_Mutation_p.S660F|CTNND1_ENST00000533667.1_Missense_Mutation_p.S438F|CTNND1_ENST00000529873.1_Missense_Mutation_p.S707F|CTNND1_ENST00000361796.4_Missense_Mutation_p.S761F|CTNND1_ENST00000527467.1_Missense_Mutation_p.S444F|CTNND1_ENST00000361332.4_Missense_Mutation_p.S761F|CTNND1_ENST00000534579.1_Missense_Mutation_p.S707F|CTNND1_ENST00000415361.2_Missense_Mutation_p.S666F|CTNND1_ENST00000399050.4_Missense_Mutation_p.S767F|CTNND1_ENST00000530748.1_Missense_Mutation_p.S713F|CTNND1_ENST00000360682.6_Missense_Mutation_p.S767F|CTNND1_ENST00000529986.1_Missense_Mutation_p.S660F|CTNND1_ENST00000528621.1_Missense_Mutation_p.S707F|CTNND1_ENST00000530094.1_Missense_Mutation_p.S660F|CTNND1_ENST00000529919.1_Missense_Mutation_p.S767F|CTNND1_ENST00000532787.1_Missense_Mutation_p.S660F|CTNND1_ENST00000532463.1_Missense_Mutation_p.S660F|CTNND1_ENST00000525902.1_Missense_Mutation_p.S444F|CTNND1_ENST00000526938.1_Missense_Mutation_p.S767F|CTNND1_ENST00000399039.4_Missense_Mutation_p.S767F|CTNND1_ENST00000532844.1_Missense_Mutation_p.S713F|CTNND1_ENST00000531014.1_Missense_Mutation_p.S438F|CTNND1_ENST00000428599.2_Missense_Mutation_p.S761F|CTNND1_ENST00000526357.1_Missense_Mutation_p.S707F|CTNND1_ENST00000532649.1_Missense_Mutation_p.S707F|CTNND1_ENST00000529526.1_Missense_Mutation_p.S707F|CTNND1_ENST00000528232.1_Missense_Mutation_p.S666F|CTNND1_ENST00000526772.1_Missense_Mutation_p.S438F			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	767					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				CAGAACTCCTCTTGGAATTTC	0.433000													15	21					0	0	1	0	0
DNAJB12	54788	broad.mit.edu	37	10	74114728	74114728	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:74114728C>T	ENST00000338820.3	-	1	179	c.30G>A	c.(28-30)gcG>gcA	p.A10A	DNAJB12_ENST00000444643.2_5'UTR|DNAJB12_ENST00000394903.2_Silent_p.A10A	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	0					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						GCCGGCGCGTCGCGGGCAGCC	0.652000													12	12					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669392	234669392	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:234669392C>T	ENST00000360418.3	+	1	459	c.459C>T	c.(457-459)ttC>ttT	p.F153F	UGT1A1_ENST00000609637.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A1_ENST00000609767.1_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A8_ENST00000305208.5_Silent_p.F153F|UGT1A6_ENST00000305139.6_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A1_ENST00000608381.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A1_ENST00000608383.1_Silent_p.F153F|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A7_ENST00000373426.3_Intron			P22309	UD11_HUMAN		153					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CGGACCCTTTCCTTCCTTGCA	0.547000													59	44					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30010610	30010610	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:30010610G>A	ENST00000346128.6	-	21	4210	c.3736C>T	c.(3736-3738)Cca>Tca	p.P1246S	TJP1_ENST00000400011.2_Missense_Mutation_p.P1170S|TJP1_ENST00000356107.6_Missense_Mutation_p.P1246S|TJP1_ENST00000545208.2_Missense_Mutation_p.P1166S	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1246	Poly-Pro.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GTTGGGGGTGGAGGCAGTGGT	0.483000													35	23					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79272967	79272967	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:79272967C>T	ENST00000419573.3	-	25	3811	c.3537G>A	c.(3535-3537)ctG>ctA	p.L1179L	RASGRF1_ENST00000560334.1_5'UTR|RP11-16K12.1_ENST00000316148.4_RNA|RASGRF1_ENST00000394745.3_Silent_p.L395L|RASGRF1_ENST00000558480.2_Silent_p.L1163L	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1181	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CTTACTTTTTCAGAGCTTCTC	0.433000													14	30					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42762623	42762623	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:42762623G>A	ENST00000330714.3	+	6	1048	c.864G>A	c.(862-864)agG>agA	p.R288R	MX2_ENST00000496774.1_3'UTR|MX2_ENST00000543692.1_Intron	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	288					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AAGGGGACAGGACCATCGGTA	0.612000													29	29					0	0	1	0	0
AMMECR1	9949	broad.mit.edu	37	X	109561181	109561181	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:109561181C>T	ENST00000262844.5	-	1	286	c.119G>A	c.(118-120)cGa>cAa	p.R40Q	AMMECR1_ENST00000372059.2_Missense_Mutation_p.R40Q|AMMECR1_ENST00000372057.1_Intron	NM_015365.2	NP_056180.1	Q9Y4X0	AMER1_HUMAN	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	40	Gly/Ser-rich.									large_intestine(1)|lung(4)|ovary(1)|stomach(1)	7						CTCCCCAGCTCGGCACTGGCT	0.692000													9	3					0	0	1	0	0
ZNF549	256051	broad.mit.edu	37	19	58049730	58049730	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:58049730C>T	ENST00000376233.3	+	4	1539	c.1358C>T	c.(1357-1359)tCa>tTa	p.S453L	ZNF549_ENST00000240719.3_Missense_Mutation_p.S440L|ZNF549_ENST00000594943.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000602149.1_Intron	NM_001199295.1	NP_001186224	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTGGGAAATCATTTATCCGC	0.428000													24	53					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36685341	36685341	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:36685341G>A	ENST00000216181.5	-	32	4577	c.4347C>T	c.(4345-4347)ctC>ctT	p.L1449L		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1449					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CCTCCGCCAGGAGCTGGGAAA	0.672000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				6	14					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161052922	161052922	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:161052922G>A	ENST00000283249.2	-	3	388	c.151C>T	c.(151-153)Cat>Tat	p.H51Y	ITGB6_ENST00000409872.1_Missense_Mutation_p.H51Y|ITGB6_ENST00000409967.2_Missense_Mutation_p.H51Y|ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000428609.2_Missense_Mutation_p.H9Y	NM_001282353.1|NM_001282354.1|NM_001282388.1	NP_001269282.1|NP_001269283.1|NP_001269317.1	P18564	ITB6_HUMAN	integrin, beta 6	51					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity	p.H51Y(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						CCAGATGGATGAGTAAAATTC	0.333000													79	45					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14859371	14859371	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:14859371G>A	ENST00000380881.4	-	5	1256	c.441C>T	c.(439-441)ttC>ttT	p.F147F	FREM1_ENST00000380880.3_Silent_p.F147F|FREM1_ENST00000422223.2_Silent_p.F147F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	147					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		ACAAGCCATTGAATTCAGGCA	0.448000													62	130					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27408250	27408250	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:27408250C>G	ENST00000326799.3	-	15	1859	c.1711G>C	c.(1711-1713)Gag>Cag	p.E571Q	YME1L1_ENST00000375972.3_Missense_Mutation_p.E481Q|YME1L1_ENST00000376016.3_Missense_Mutation_p.E514Q	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	571					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						TTGGAAAACTCCAGCTCCTTC	0.378000													35	83					0	0	1	0	0
ARPC1A	10552	broad.mit.edu	37	7	98951540	98951540	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:98951540C>T	ENST00000432884.2	+	8	829	c.368C>T	c.(367-369)tCt>tTt	p.S123F	ARPC1A_ENST00000262942.5_Missense_Mutation_p.S170F			Q92747	ARC1A_HUMAN	actin related protein 2/3 complex, subunit 1A, 41kDa	170					actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			endometrium(3)|large_intestine(5)|liver(2)|lung(7)|ovary(1)|prostate(1)	19	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			AGAGTGTTTTCTGCCTACATT	0.458000													71	38					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52557301	52557301	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:52557301G>A	ENST00000321725.6	+	64	7160	c.7084G>A	c.(7084-7086)Gag>Aag	p.E2362K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2362	FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCTGGATGATGAGCTCACGTA	0.547000													54	83					0	0	1	0	0
VAMP1	6843	broad.mit.edu	37	12	6575088	6575088	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:6575088C>T	ENST00000361716.3	-	3	663	c.208G>A	c.(208-210)Gat>Aat	p.D70N	VAMP1_ENST00000544432.1_5'UTR|VAMP1_ENST00000400911.3_Missense_Mutation_p.D70N|VAMP1_ENST00000396308.3_Missense_Mutation_p.D70N|TAPBPL_ENST00000545700.1_3'UTR|VAMP1_ENST00000535180.1_Missense_Mutation_p.D70N			P23763	VAMP1_HUMAN	vesicle-associated membrane protein 1 (synaptobrevin 1)	70	v-SNARE coiled-coil homology.				neurotransmitter secretion|vesicle-mediated transport	cell junction|endocytic vesicle membrane|integral to plasma membrane|mitochondrial outer membrane|synaptic vesicle membrane|synaptosome	protein binding			endometrium(1)|large_intestine(1)|prostate(1)	3					Botulinum Toxin Type B(DB00042)	TGCAAGGCATCAGCTCGGTCA	0.512000											OREG0021627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	57					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161132481	161132481	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161132481C>T	ENST00000368002.3	+	6	1235	c.858C>T	c.(856-858)gtC>gtT	p.V286V	USP21_ENST00000368001.1_Silent_p.V286V|USP21_ENST00000289865.8_Silent_p.V286V	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	286					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TCCGAGCTGTCTTCCAGAAAT	0.562000													24	17					0	0	1	0	0
TRAV12-3	28672	broad.mit.edu	37	14	22434277	22434277	+	RNA	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:22434277C>G	ENST00000390442.3	+	0	386																											CCACCTACCTCTGTGCAATGA	0.502000													60	119					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44219858	44219858	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:44219858G>A	ENST00000371554.1	+	10	1799	c.1585G>A	c.(1585-1587)Gat>Aat	p.D529N	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.D529N|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.D529N			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	529					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CAAGGAATTTGATGGGAAGAG	0.517000													19	30					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200957427	200957427	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:200957427G>C	ENST00000332129.2	-	24	3721	c.3405C>G	c.(3403-3405)ttC>ttG	p.F1135L	KIF21B_ENST00000360529.5_Missense_Mutation_p.F1135L|KIF21B_ENST00000461742.2_Missense_Mutation_p.F1135L|KIF21B_ENST00000422435.2_Missense_Mutation_p.F1135L	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1135					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GGCTCACCTTGAACTTGAAAT	0.582000													20	117					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4013020	4013020	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4013020G>C	ENST00000381638.2	-	6	1328	c.1204C>G	c.(1204-1206)Ctg>Gtg	p.L402V	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	402	DOC.						calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GATGTCAGCAGAGACCAATAC	0.483000													29	31					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42906928	42906928	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:42906928C>T	ENST00000244289.4	-	9	3074	c.2798G>A	c.(2797-2799)aGa>aAa	p.R933K	LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	933					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				GCCCAGGCCTCTGTCCATGGG	0.607000													17	51					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76045402	76045402	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:76045402C>T	ENST00000238667.4	+	1	443	c.87C>T	c.(85-87)gtC>gtT	p.V29V	AC007182.6_ENST00000455232.1_RNA	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	29	8 X 6 AA tandem repeats of P-S-[VS]-S- [VIAG]-[HNP].				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCGTCTCGGTCCATCCCAGCG	0.637000													69	133					0	0	1	0	0
NDC80	10403	broad.mit.edu	37	18	2606449	2606449	+	Silent	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:2606449G>T	ENST00000261597.4	+	14	1682	c.1500G>T	c.(1498-1500)gtG>gtT	p.V500V		NM_006101.2	NP_006092.1	O14777	NDC80_HUMAN	NDC80 kinetochore complex component	500	Interaction with NEK2 and ZWINT.|Interaction with PSMC2 and SMC1A.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			NS(1)|biliary_tract(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)|urinary_tract(2)	22						AGAGAAGTGTGAGAACTCTGA	0.323000													24	45					7.41945e-09	7.57325e-09	1	1	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625176	74625176	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:74625176C>T	ENST00000156626.7	-	2	948	c.749G>A	c.(748-750)aGa>aAa	p.R250K	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	250					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GGCCTTCAGTCTTTGGTTTCT	0.537000													36	91					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524560	187524560	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:187524560G>C	ENST00000441802.2	-	19	11329	c.11120C>G	c.(11119-11121)tCa>tGa	p.S3707*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3707					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTGTTTTGTTGAGATCTGAGC	0.433000										HNSCC(5;0.00058)			8	27					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170811656	170811656	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:170811656G>A	ENST00000436636.2	-	23	3037	c.2693C>T	c.(2692-2694)tCa>tTa	p.S898L	TNIK_ENST00000369326.5_Missense_Mutation_p.S876L|TNIK_ENST00000475336.1_Missense_Mutation_p.S806L|TNIK_ENST00000460047.1_Missense_Mutation_p.S835L|TNIK_ENST00000488470.1_Missense_Mutation_p.S843L|TNIK_ENST00000284483.8_Missense_Mutation_p.S890L|TNIK_ENST00000470834.1_Missense_Mutation_p.S861L|TNIK_ENST00000538048.1_Missense_Mutation_p.S850L|TNIK_ENST00000357327.5_Missense_Mutation_p.S869L|TNIK_ENST00000341852.6_Missense_Mutation_p.S814L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	898	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCCTTCTCTTGAAATACTGCC	0.463000													17	21					0	0	1	0	0
UBAP1	51271	broad.mit.edu	37	9	34249794	34249794	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:34249794C>T	ENST00000536252.1	+	6	1499	c.1101C>T	c.(1099-1101)ttC>ttT	p.F367F	UBAP1_ENST00000297661.4_Silent_p.F367F|UBAP1_ENST00000359544.2_Silent_p.F367F|UBAP1_ENST00000545103.1_Silent_p.F431F|UBAP1_ENST00000540348.1_Silent_p.F367F|UBAP1_ENST00000379186.4_Intron|UBAP1_ENST00000543944.1_Silent_p.F403F	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	367						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			CTCCTAATTTCTCAGTGTCAC	0.557000													35	74					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64878010	64878010	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:64878010G>C	ENST00000279281.3	+	8	2027	c.1935G>C	c.(1933-1935)aaG>aaC	p.K645N	VPS51_ENST00000527646.1_3'UTR	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		ACTCCAGCAAGAGGACTTTCT	0.637000											OREG0021071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	81	246					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58260692	58260692	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:58260692G>A	ENST00000300896.4	-	31	4151	c.3957C>T	c.(3955-3957)ctC>ctT	p.L1319L	USP32_ENST00000592339.1_Silent_p.L989L	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1319					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.L1319L(1)		NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TATGCTGGCAGAGAGCCGGGT	0.493000													46	100					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758433	19758433	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19758433G>A	ENST00000357324.6	-	20	2794	c.2768C>T	c.(2767-2769)tCc>tTc	p.S923F	ATP13A1_ENST00000291503.5_Missense_Mutation_p.S805F	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	923					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CTGCTCCTCGGAGGGAGGGAG	0.692000													6	35					0	0	1	0	0
PIK3R4	30849	broad.mit.edu	37	3	130435391	130435391	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:130435391G>A	ENST00000356763.3	-	9	2737	c.2180C>T	c.(2179-2181)tCt>tTt	p.S727F		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	727					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						ATCAAATATAGAACGACTTAC	0.353000													12	34					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19441973	19441973	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:19441973G>A	ENST00000375267.2	-	74	10985	c.10982C>T	c.(10981-10983)cCt>cTt	p.P3661L	UBR4_ENST00000375217.2_Missense_Mutation_p.P3654L|UBR4_ENST00000375226.2_Missense_Mutation_p.P3637L|UBR4_ENST00000375218.3_Missense_Mutation_p.P76L|UBR4_ENST00000375254.3_Missense_Mutation_p.P3661L			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3661					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ACTACAGCGAGGGCACTGCAG	0.527000													47	72					0	0	1	0	0
SHBG	6462	broad.mit.edu	37	17	7533733	7533733	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:7533733G>C	ENST00000380450.4	+	2	142		c.e2-1		SHBG_ENST00000576728.1_Intron|SHBG_ENST00000572262.1_Intron|SHBG_ENST00000416273.3_Splice_Site|SHBG_ENST00000570547.1_Intron|SHBG_ENST00000340624.5_Splice_Site|SHBG_ENST00000575314.1_Intron|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000576478.1_Intron|SHBG_ENST00000574539.1_Intron|SHBG_ENST00000441599.2_Splice_Site|SHBG_ENST00000575903.1_Splice_Site	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin						hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	CTTTCTGATAGAGTGCCCACG	0.542000													62	28					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449261	35449261	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:35449261G>A	ENST00000404801.1	-	4	1884	c.1498C>T	c.(1498-1500)Cac>Tac	p.H500Y	ZNF792_ENST00000605484.1_Missense_Mutation_p.H433Y	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TCACCAGTGTGAAGTCTCCGA	0.512000													27	38					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51503070	51503070	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:51503070C>T	ENST00000396402.1	-	10	1600	c.1447G>A	c.(1447-1449)Gag>Aag	p.E483K	CYP19A1_ENST00000396404.4_Missense_Mutation_p.E483K|CYP19A1_ENST00000260433.2_Missense_Mutation_p.E483K|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000559878.1_Missense_Mutation_p.E483K	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	483					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TTTTTAGTCTCATCTGGGTGC	0.463000													37	141					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123333164	123333164	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:123333164C>G	ENST00000360772.3	-	34	5758	c.5380G>C	c.(5380-5382)Gat>Cat	p.D1794H	MYLK_ENST00000475616.1_Missense_Mutation_p.D1845H|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000354792.5_Missense_Mutation_p.D645H|MYLK_ENST00000359169.1_Missense_Mutation_p.D1794H|MYLK_ENST00000346322.5_Missense_Mutation_p.D1776H|MYLK_ENST00000583087.1_Missense_Mutation_p.D85H|MYLK_ENST00000360304.3_Missense_Mutation_p.D1845H|MYLK_ENST00000418370.2_Missense_Mutation_p.D85H|MYLK-AS1_ENST00000470449.1_RNA|MYLK_ENST00000578202.1_Missense_Mutation_p.D84H|MYLK-AS1_ENST00000485162.1_RNA			Q15746	MYLK_HUMAN	myosin light chain kinase	1845					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GACTGGTCATCTTTGAACCAG	0.468000													21	50					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156821484	156821484	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:156821484G>A	ENST00000368195.3	-	4	1434	c.1038C>T	c.(1036-1038)ggC>ggT	p.G346G	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	346					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CATGCGTGCAGCCCACAAGAT	0.587000													7	43					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128846482	128846482	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:128846482G>A	ENST00000310343.9	-	19	2127	c.2128C>T	c.(2128-2130)Ctt>Ttt	p.L710F	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.L361F|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.L361F|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.L636F	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	710					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						AGAGATGTAAGAGACTCCTCA	0.348000													26	28					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	132937934	132937934	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:132937934C>G	ENST00000253861.4	+	1	106	c.77C>G	c.(76-78)tCt>tGt	p.S26C	EXOC4_ENST00000393161.2_Missense_Mutation_p.S26C	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	26					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				CTGCTCATCTCTGTGATCAGG	0.627000													33	57					0	0	1	0	0
RPS16	6217	broad.mit.edu	37	19	39924298	39924298	+	Missense_Mutation	SNP	G	G	A	rs11555713		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:39924298G>A	ENST00000339471.4	-	3	294	c.254C>T	c.(253-255)tCc>tTc	p.S85F	RPS16_ENST00000601655.1_Intron|RPS16_ENST00000599539.1_Intron|RPS16_ENST00000251453.3_Intron			P62249	RS16_HUMAN	ribosomal protein S16	85					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)|large_intestine(2)|lung(2)|skin(2)	7	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGTTCCTGGGACTCACCATA	0.562000													33	34					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32120441	32120441	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:32120441C>T	ENST00000373672.3	-	68	4825	c.4309G>A	c.(4309-4311)Gat>Aat	p.D1437N	RP11-73M7.6_ENST00000609033.1_RNA|RP11-73M7.6_ENST00000609338.1_RNA|RP11-73M7.6_ENST00000610043.1_RNA|COL16A1_ENST00000271069.6_Missense_Mutation_p.D1437N|RP11-73M7.6_ENST00000608332.1_RNA|RP11-73M7.6_ENST00000589462.1_RNA|RP11-73M7.6_ENST00000593188.1_RNA|RP11-73M7.6_ENST00000609373.1_RNA|RP11-73M7.6_ENST00000585413.1_RNA|COL16A1_ENST00000461217.1_5'UTR|RP11-73M7.6_ENST00000591929.1_RNA|RP11-73M7.6_ENST00000591592.1_RNA|RP11-73M7.6_ENST00000585660.1_RNA|RP11-73M7.6_ENST00000610216.1_RNA|RP11-73M7.6_ENST00000608246.1_RNA|RP11-73M7.6_ENST00000608888.1_RNA|RP11-73M7.6_ENST00000609625.1_RNA|RP11-73M7.6_ENST00000607926.1_RNA|RP11-73M7.6_ENST00000587445.1_RNA|RP11-73M7.6_ENST00000609549.1_RNA	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1437	Nonhelical region 2 (NC2).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TTGATTTCATCATAATTCACC	0.448000													62	116					0	0	1	0	0
FAM84B	157638	broad.mit.edu	37	8	127569296	127569296	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:127569296G>A	ENST00000304916.3	-	2	794	c.339C>T	c.(337-339)ctC>ctT	p.L113L	RP11-103H7.5_ENST00000524320.1_RNA	NM_174911.4	NP_777571.1	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	113						cytoplasm|plasma membrane	protein binding			lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			TGCACTTGTTGAGCAGGTTCT	0.612000													21	49					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769302	247769302	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:247769302C>T	ENST00000320002.2	+	1	447	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R139R(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATGAACCCACGGCTTTGCCA	0.512000													28	124					0	0	1	0	0
CAPG	822	broad.mit.edu	37	2	85622043	85622043	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:85622043G>A	ENST00000263867.4	-	10	1269	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	CAPG_ENST00000409921.1_Silent_p.F325F|CAPG_ENST00000409670.1_Silent_p.F340F|CAPG_ENST00000409724.1_Silent_p.F340F	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	340					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						AAAATTGCTTGAAGATGGGAC	0.597000													5	48					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49631242	49631242	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:49631242G>A	ENST00000334186.4	+	2	461	c.112G>A	c.(112-114)Gag>Aag	p.E38K	PPFIA3_ENST00000602351.1_Missense_Mutation_p.E38K	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	38						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GATGCTCACGGAGCGCGAGCG	0.726000													21	46					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37901234	37901234	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:37901234C>T	ENST00000309156.4	+	9	1265	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	GRB7_ENST00000394204.1_Silent_p.F336F|GRB7_ENST00000394211.3_Silent_p.F336F|GRB7_ENST00000445327.2_Silent_p.F359F|GRB7_ENST00000309185.3_Silent_p.F336F|GRB7_ENST00000394209.2_Silent_p.F336F	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	336	PH.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCCGCCTCTTCAAGGTGAGAC	0.617000													9	18					0	0	1	0	0
CHID1	66005	broad.mit.edu	37	11	884097	884097	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:884097G>A	ENST00000449825.1	-	9	1130	c.774C>T	c.(772-774)ctC>ctT	p.L258L	CHID1_ENST00000526714.1_Intron|CHID1_ENST00000528581.1_Silent_p.L283L|CHID1_ENST00000323578.8_Silent_p.L258L|CHID1_ENST00000323541.7_Silent_p.L288L|CHID1_ENST00000336845.5_Silent_p.L283L|CHID1_ENST00000454838.2_Silent_p.L283L|CHID1_ENST00000436108.2_Silent_p.L258L|CHID1_ENST00000429789.2_Silent_p.L227L	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	258					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		CGTAGGTCATGAGGCTGAAAC	0.602000													16	54					0	0	1	0	0
NDUFB6	4712	broad.mit.edu	37	9	32572968	32572968	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:32572968G>A	ENST00000379847.3	-	1	192	c.91C>T	c.(91-93)Cgg>Tgg	p.R31W	NDUFB6_ENST00000350021.2_Missense_Mutation_p.R31W	NM_002493.4	NP_002484.1	O95139	NDUB6_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa	31					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity	p.R31G(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|urinary_tract(1)	8			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00199)	NADH(DB00157)	ACCGGCTCCCGAGGGCTCAGC	0.562000											OREG0019131	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	55					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24409086	24409086	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:24409086G>C	ENST00000330966.7	-	17	2254	c.2092C>G	c.(2092-2094)Ctg>Gtg	p.L698V	RP11-293P20.2_ENST00000439239.2_RNA|MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.L697V|MYOM3_ENST00000374434.3_Missense_Mutation_p.L697V|RP11-293P20.4_ENST00000429191.1_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	697										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GACTCACCCAGAGCCTGCTTG	0.642000													14	53					0	0	1	0	0
LIN7B	64130	broad.mit.edu	37	19	49619676	49619676	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:49619676G>A	ENST00000221459.2	+	4	429	c.385G>A	c.(385-387)Gac>Aac	p.D129N	LIN7B_ENST00000391864.3_Intron	NM_022165.2	NP_071448.1	Q9HAP6	LIN7B_HUMAN	lin-7 homolog B (C. elegans)	129	PDZ.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein domain specific binding			central_nervous_system(1)|endometrium(1)|prostate(1)	3		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;5e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000191)|GBM - Glioblastoma multiforme(486;0.00449)|Epithelial(262;0.01)		GGGTGTGGCTGACCGCCATGG	0.597000													27	42					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25261687	25261687	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:25261687C>G	ENST00000395990.2	-	17	2083	c.1826G>C	c.(1825-1827)aGa>aCa	p.R609T	CASC1_ENST00000545133.1_Missense_Mutation_p.R590T|CASC1_ENST00000354189.5_3'UTR|CASC1_ENST00000537577.1_3'UTR|CASC1_ENST00000320267.9_Missense_Mutation_p.R649T|CASC1_ENST00000395987.3_Missense_Mutation_p.R655T	NM_001204102.1	NP_001191031	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	649										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TCTTTGTGCTCTGTCACCACT	0.368000													9	40					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104240641	104240641	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:104240641G>A	ENST00000369905.4	-	11	1173	c.1110C>T	c.(1108-1110)tcC>tcT	p.S370S	ACTR1A_ENST00000446605.2_Silent_p.S323S|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000545684.1_Silent_p.S296S|ACTR1A_ENST00000487599.1_3'UTR	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	370					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TTCTGTGGATGGATCGGGCAC	0.493000													28	31					0	0	1	0	0
JTB	10899	broad.mit.edu	37	1	153949189	153949189	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:153949189G>A	ENST00000271843.4	-	3	619	c.184C>T	c.(184-186)Cca>Tca	p.P62S	JTB_ENST00000356648.1_Missense_Mutation_p.P33S|JTB_ENST00000368589.1_Missense_Mutation_p.P33S|JTB_ENST00000471173.1_5'UTR	NM_006694.3	NP_006685.1	O76095	JTB_HUMAN	jumping translocation breakpoint	62					apoptosis|cell cycle cytokinesis|mitosis|positive regulation of protein kinase activity	integral to plasma membrane|membrane fraction|microtubule organizing center|midbody|mitochondrion|spindle	protein kinase binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)	10	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTAGAGCATGGAGAGCACTCT	0.423000													24	81					0	0	1	0	0
GGT6	124975	broad.mit.edu	37	17	4463722	4463722	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4463722G>A	ENST00000301395.3	-	1	154	c.95C>T	c.(94-96)tCa>tTa	p.S32L	GGT6_ENST00000381550.3_Missense_Mutation_p.S32L|GGT6_ENST00000574154.1_Missense_Mutation_p.S32L	NM_153338.2	NP_699169.2	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6	32					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						CAGCGCCTCTGATGTCTCCTC	0.627000													51	30					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214551305	214551305	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:214551305C>T	ENST00000366956.5	-	14	2879	c.2685G>A	c.(2683-2685)gaG>gaA	p.E895E	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	895					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CACTTACCCTCTCGTCCATGG	0.537000													14	87					0	0	1	0	0
RPL15	6138	broad.mit.edu	37	3	23959451	23959451	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:23959451C>T	ENST00000307839.5	+	2	740	c.101C>T	c.(100-102)tCt>tTt	p.S34F	RPL15_ENST00000415719.1_Missense_Mutation_p.S34F|RPL15_ENST00000413699.1_Missense_Mutation_p.S34F|RPL15_ENST00000456530.2_Missense_Mutation_p.S34F|RPL15_ENST00000354811.5_Missense_Mutation_p.S34F|RPL15_ENST00000435882.1_Missense_Mutation_p.S34F|NKIRAS1_ENST00000421515.2_Intron	NM_001253379.1|NM_001253380.1|NM_002948.3	NP_001240308.1|NP_001240309.1|NP_002939.2	P61313	RL15_HUMAN	ribosomal protein L15	34					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7						CGCCAGCTCTCTGCTCTCCAC	0.587000													24	43					0	0	1	0	0
DNAJC9	23234	broad.mit.edu	37	10	75006494	75006494	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:75006494G>A	ENST00000372950.4	-	2	1945	c.273C>T	c.(271-273)ctC>ctT	p.L91L		NM_015190.3	NP_056005.1	Q8WXX5	DNJC9_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 9	91					protein folding		heat shock protein binding|unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(2)|stomach(1)	6	Prostate(51;0.0119)					GGTCTTGGGTGAGCACAGGAG	0.493000													25	40					0	0	1	0	0
FAM212B	55924	broad.mit.edu	37	1	112281840	112281840	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:112281840C>T	ENST00000357260.5	-	1	206	c.25G>A	c.(25-27)Gac>Aac	p.D9N	FAM212B_ENST00000534365.1_Missense_Mutation_p.D9N|FAM212B_ENST00000444059.2_Intron	NM_019099.4	NP_061972.1	Q9NTI7	CA183_HUMAN	family with sequence similarity 212, member B	9										cervix(1)|endometrium(1)	2						AGATAGCAGTCCATTTCCCTG	0.662000													18	29					0	0	1	0	0
MAPK13	5603	broad.mit.edu	37	6	36106813	36106813	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:36106813C>T	ENST00000211287.4	+	11	1261	c.999C>T	c.(997-999)ctC>ctT	p.L333L	MAPK13_ENST00000373766.5_3'UTR|MAPK13_ENST00000373761.6_Silent_p.L323L|MAPK13_ENST00000373759.1_3'UTR	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	333					cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						ACGAGAAACTCACAGTGGATG	0.587000													7	30					0	0	1	0	0
ORMDL3	94103	broad.mit.edu	37	17	38080295	38080295	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:38080295G>A	ENST00000394169.1	-	4	1656	c.162C>T	c.(160-162)ctC>ctT	p.L54L	ORMDL3_ENST00000579695.1_Silent_p.L54L|ORMDL3_ENST00000304046.2_Silent_p.L54L|ORMDL3_ENST00000584220.1_Intron			Q8N138	ORML3_HUMAN	ORM1-like 3 (S. cerevisiae)	54					ceramide metabolic process	integral to membrane|SPOTS complex	protein binding			endometrium(3)|kidney(1)|lung(1)	5	Colorectal(19;0.000442)		Lung(15;0.0234)			TGTTGTGAATGAGGTTGGTGA	0.627000													7	24					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942583	144942583	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:144942583G>A	ENST00000525985.1	-	2	4910	c.4839C>T	c.(4837-4839)ttC>ttT	p.F1613F				P58107	EPIPL_HUMAN	epiplakin 1	1613						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTCGATGATGAAGCCGGTAG	0.627000													23	39					0	0	1	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042553	59042553	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:59042553C>G	ENST00000371225.2	-	1	613	c.276G>C	c.(274-276)ccG>ccC	p.P92P		NM_002353.2	NP_002344.2	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	92	Thyroglobulin type-1.				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity					all_cancers(7;6.54e-05)					CGTGCTCACTCGGCCGCACCA	0.687000													5	5					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7310217	7310217	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:7310217C>T	ENST00000537408.1	+	16	3234	c.2696C>T	c.(2695-2697)tCc>tTc	p.S899F	CLSTN3_ENST00000266546.6_Missense_Mutation_p.S887F|CLSTN3_ENST00000331148.5_3'UTR			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	887					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CCAGGGGCCTCCAGTGACCCC	0.647000													7	14					0	0	1	0	0
HOXB8	3218	broad.mit.edu	37	17	46690720	46690720	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:46690720G>A	ENST00000239144.4	-	2	810	c.576C>T	c.(574-576)atC>atT	p.I192I	HOXB7_ENST00000567101.2_Intron|HOXB8_ENST00000576562.1_Silent_p.I191I	NM_024016.3	NP_076921.1	P17481	HXB8_HUMAN	homeobox B8	192						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(8)|urinary_tract(2)	11						TCTGGAACCAGATTTTGACCT	0.507000													35	66					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278591	50278591	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:50278591G>A	ENST00000442544.2	+	2	875	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	DCC_ENST00000412726.1_5'UTR	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	87	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GGGAATGGATGAAAGGAAGCA	0.498000													23	56					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5625815	5625815	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:5625815G>A	ENST00000380097.3	+	3	801	c.559G>A	c.(559-561)Gag>Aag	p.E187K	TRIM6_ENST00000278302.5_Missense_Mutation_p.E159K|HBG2_ENST00000380259.2_Intron|TRIM6-TRIM34_ENST00000354852.5_Missense_Mutation_p.E187K|TRIM6_ENST00000515022.1_Intron|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000380107.1_Missense_Mutation_p.E133K|TRIM6_ENST00000507320.1_5'UTR|TRIM6_ENST00000506134.1_5'UTR|TRIM6_ENST00000445329.1_5'UTR	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCAGGAAGCTGAGAAGCTAAC	0.458000													73	47					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79686097	79686097	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:79686097A>T	ENST00000372391.2	-	1	187	c.182T>A	c.(181-183)tTg>tAg	p.L61*	DLG5_ENST00000372388.2_Nonsense_Mutation_p.L61*	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	61					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTCCTTGGCCAAGAGCAGCTT	0.716000													5	4					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30357710	30357710	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:30357710G>T	ENST00000327564.7	+	4	2001	c.1940G>T	c.(1939-1941)aGa>aTa	p.R647I	LRRC37B_ENST00000584368.1_Intron|LRRC37B_ENST00000394713.3_Intron|LRRC37B_ENST00000341671.7_Missense_Mutation_p.R620I|LRRC37B_ENST00000543378.2_Missense_Mutation_p.R538I			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	620						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TATATTGAAAGACAAACATTT	0.244000													3	22					0.115264	0.115507	1	1	0
TBC1D7	51256	broad.mit.edu	37	6	13307930	13307930	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:13307930C>T	ENST00000607658.1	-	5	636	c.486G>A	c.(484-486)ctG>ctA	p.L162L	TBC1D7_ENST00000607532.1_5'UTR|TBC1D7_ENST00000343141.4_Silent_p.L143L|TBC1D7_ENST00000379307.2_Silent_p.L162L|TBC1D7_ENST00000356436.4_Silent_p.L189L|TBC1D7_ENST00000379300.3_Silent_p.L189L			Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7	189	Rab-GAP TBC.				positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			TCAGATGAGTCAGCAGTCTGC	0.438000													14	50					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213242	9213242	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:9213242C>G	ENST00000305456.2	-	1	740	c.741G>C	c.(739-741)ttG>ttC	p.L247F		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						ATGGCATTCTCAAAACACAGG	0.443000													30	65					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29162548	29162548	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:29162548G>T	ENST00000321990.4	+	2	1827	c.1449G>T	c.(1447-1449)aaG>aaT	p.K483N	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	483					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGAAGAATAAGAAAACATTAG	0.313000													20	67					4.35082e-09	4.45055e-09	1	1	0
ZNF560	147741	broad.mit.edu	37	19	9583855	9583855	+	Splice_Site	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:9583855C>T	ENST00000301480.4	-	5	451	c.238G>A	c.(238-240)Gac>Aac	p.D80N		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	80	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AAATACTCACCTTGGAGAACT	0.398000													51	117					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31919196	31919196	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31919196C>G	ENST00000456570.1	+	28	3596	c.3541C>G	c.(3541-3543)Cgg>Ggg	p.R1181G	CFB_ENST00000425368.2_Missense_Mutation_p.R679G|CFB_ENST00000477310.1_Missense_Mutation_p.R1030G|CFB_ENST00000556679.1_Missense_Mutation_p.R1181G			P00751	CFAB_HUMAN	complement factor B	679					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GGTCACCCCTCGGTTCCTTTG	0.527000													30	53					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65288637	65288637	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:65288637C>T	ENST00000284037.5	+	3	480	c.91C>T	c.(91-93)Cat>Tat	p.H31Y	ERBB2IP_ENST00000511297.1_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000380936.1_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.H31Y|ERBB2IP_ENST00000416865.2_Missense_Mutation_p.H31Y	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	31					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGATTATTCTCATTGCAGCTT	0.393000													23	62					0	0	1	0	0
HSPA6	3310	broad.mit.edu	37	1	161496076	161496076	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161496076C>T	ENST00000309758.4	+	1	2041	c.1628C>T	c.(1627-1629)tCg>tTg	p.S543L	RP11-25K21.6_ENST00000537821.2_RNA	NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	543					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCCAAAAACTCGCTGGAGGCC	0.547000													8	16					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34558670	34558670	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:34558670G>A	ENST00000374789.3	-	22	3668	c.3343C>T	c.(3343-3345)Cag>Tag	p.Q1115*	PARD3_ENST00000545260.1_Nonsense_Mutation_p.Q1025*|PARD3_ENST00000346874.4_Nonsense_Mutation_p.Q1078*|PARD3_ENST00000350537.4_Nonsense_Mutation_p.Q1069*|PARD3_ENST00000374790.3_Nonsense_Mutation_p.Q1055*|PARD3_ENST00000374788.3_Nonsense_Mutation_p.Q1112*|PARD3_ENST00000545693.1_Nonsense_Mutation_p.Q1099*|PARD3_ENST00000374794.3_Nonsense_Mutation_p.Q1003*	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1115					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CGTGGGCTCTGAGGTCTAGCG	0.488000													18	36					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38746215	38746215	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:38746215C>G	ENST00000359357.3	+	12	1617	c.1363C>G	c.(1363-1365)Cag>Gag	p.Q455E	DNAH8_ENST00000449981.2_Missense_Mutation_p.Q672E|DNAH8_ENST00000441566.1_Missense_Mutation_p.Q455E					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTTATCTTCTCAGCAGGCTCT	0.294000													13	40					0	0	1	0	0
GFM2	84340	broad.mit.edu	37	5	74018260	74018260	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:74018260G>A	ENST00000296805.3	-	20	2612	c.2155C>T	c.(2155-2157)Cag>Tag	p.Q719*	GFM2_ENST00000509430.1_Nonsense_Mutation_p.Q719*|GFM2_ENST00000345239.2_Nonsense_Mutation_p.Q672*|GFM2_ENST00000515125.1_5'UTR	NM_032380.3	NP_115756.2	Q969S9	RRF2M_HUMAN	G elongation factor, mitochondrial 2	719					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(5)|prostate(1)	14		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TGGCGAGTCTGAATTTCCTGA	0.398000													30	49					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387734	46387734	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:46387734C>T	ENST00000302165.3	-	1	1642	c.1299G>A	c.(1297-1299)ctG>ctA	p.L433L		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		GTGAGTGGCCCAGGGCTTCGG	0.726000													20	24					0	0	1	0	0
GGH	8836	broad.mit.edu	37	8	63951279	63951279	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:63951279C>G	ENST00000260118.6	-	1	451	c.49G>C	c.(49-51)Ggg>Cgg	p.G17R		NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	17					glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CTCGCCGCCCCGCAGAGTAGC	0.721000													8	23					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125487147	125487147	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:125487147G>C	ENST00000259466.1	+	1	879	c.879G>C	c.(877-879)ctG>ctC	p.L293L		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						TCTACAGCCTGAGGAACAAAG	0.413000													11	35					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8153608	8153608	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:8153608G>A	ENST00000402384.3	-	14	1663	c.1397C>T	c.(1396-1398)tCa>tTa	p.S466L	ICA1_ENST00000406470.2_Missense_Mutation_p.S466L|ICA1_ENST00000422063.2_Missense_Mutation_p.S495L|ICA1_ENST00000265577.7_Missense_Mutation_p.S465L|ICA1_ENST00000396675.3_Missense_Mutation_p.S466L|ICA1_ENST00000401396.1_Missense_Mutation_p.S454L			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	466					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		ATCAGGATTTGAGAGTGGGTC	0.542000													58	53					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33233522	33233522	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:33233522C>T	ENST00000401073.2	+	2	440	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	KIAA1522_ENST00000373480.1_Nonsense_Mutation_p.Q65*|KIAA1522_ENST00000294521.3_Nonsense_Mutation_p.Q65*|KIAA1522_ENST00000373481.3_Nonsense_Mutation_p.Q76*	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	65										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GCTGCACACTCAGGCCCAGGA	0.637000													21	61					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8793080	8793080	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:8793080C>T	ENST00000359865.3	+	8	2114	c.1972C>T	c.(1972-1974)Caa>Taa	p.Q658*	SOGA2_ENST00000518815.1_Intron|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000400050.3_Intron|SOGA2_ENST00000306329.11_Intron|SOGA2_ENST00000517570.1_Intron	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	980																	CAGACTGCATCAAGAGGAGAC	0.507000													45	143					0	0	1	0	0
RPL13	6137	broad.mit.edu	37	16	89628134	89628134	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:89628134C>T	ENST00000393099.3	+	3	644	c.395C>T	c.(394-396)tCg>tTg	p.S132L	RPL13_ENST00000311528.5_Missense_Mutation_p.S132L|RPL13_ENST00000452368.3_Intron|RPL13_ENST00000567815.1_Missense_Mutation_p.S132L	NM_033251.2	NP_150254.1	P26373	RL13_HUMAN	ribosomal protein L13	132					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic ribosome	protein binding|RNA binding|structural constituent of ribosome			lung(3)|skin(1)|upper_aerodigestive_tract(2)	6		all_hematologic(23;0.0748)		all cancers(4;1.15e-07)|OV - Ovarian serous cystadenocarcinoma(4;7.8e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0139)		AGGAAGCCCTCGGCCCCCAAG	0.622000													12	28					0	0	1	0	0
C1orf56	54964	broad.mit.edu	37	1	151020668	151020668	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:151020668C>T	ENST00000368926.5	+	1	453	c.345C>T	c.(343-345)gcC>gcT	p.A115A		NM_017860.3	NP_060330.2	Q9BUN1	CA056_HUMAN	chromosome 1 open reading frame 56	115						extracellular region				endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGATTAATGCCGGAAAGGATA	0.567000													19	61					0	0	1	0	0
FAM86A	196483	broad.mit.edu	37	16	5140234	5140234	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:5140234C>T	ENST00000427587.4	-	6	661	c.593G>A	c.(592-594)cGa>cAa	p.R198Q	FAM86A_ENST00000587133.1_Missense_Mutation_p.R137Q|FAM86A_ENST00000458008.4_Missense_Mutation_p.R164Q	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	198										endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						GACATTCCCTCGGAGCTGCTC	0.617000													26	56					0	0	1	0	0
B2M	567	broad.mit.edu	37	15	45003745	45003745	+	Translation_Start_Site	SNP	A	A	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:45003745A>C	ENST00000558401.1	+	1	71	c.1A>C	c.(1-3)Atg>Ctg	p.M1L	B2M_ENST00000559916.1_Start_Codon_SNP_p.M1L|B2M_ENST00000544417.1_Start_Codon_SNP_p.M1L	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	1					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.M1L(3)|p.M1V(2)|p.?(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TCGGGCCGAGATGTCTCGCTC	0.612000													24	27					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46972801	46972801	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:46972801C>T	ENST00000371956.4	+	1	134	c.119C>T	c.(118-120)tCa>tTa	p.S40L	DMBX1_ENST00000360032.3_Missense_Mutation_p.S40L	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	40	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					TACCGGCCTTCAGTGCATGCG	0.632000													4	59					0	0	1	0	0
NMI	9111	broad.mit.edu	37	2	152127335	152127335	+	Nonsense_Mutation	SNP	G	G	A	rs146399920		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:152127335G>A	ENST00000243346.5	-	8	1266	c.796C>T	c.(796-798)Caa>Taa	p.Q266*		NM_004688.2	NP_004679.2	Q13287	NMI_HUMAN	N-myc (and STAT) interactor	266					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				BRCA - Breast invasive adenocarcinoma(221;0.0571)		TCATCCATTTGAATGCCTTCC	0.368000													30	12					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10541684	10541684	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10541684C>T	ENST00000293683.5	+	1	164	c.164C>T	c.(163-165)cCg>cTg	p.P55L	PDE4A_ENST00000352831.6_Intron|PDE4A_ENST00000380702.2_Intron|PDE4A_ENST00000592685.1_Intron	NM_001111308.1	NP_001104778.1	P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	331					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	ttcgccagcccgtccccAACT	0.741000													5	7					0	0	1	0	0
TCF25	22980	broad.mit.edu	37	16	89967141	89967141	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:89967141G>C	ENST00000263346.8	+	12	1376	c.1320G>C	c.(1318-1320)caG>caC	p.Q440H	TCF25_ENST00000263347.7_Missense_Mutation_p.Q205H	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	440					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		AGTGTGAGCAGAGCTCTGCCA	0.587000													22	35					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72350302	72350302	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:72350302G>C	ENST00000389916.4	+	18	2448	c.2310G>C	c.(2308-2310)gaG>gaC	p.E770D		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	770					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCGCTGCAGAGAGGAAGGAGA	0.662000													34	133					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110146084	110146084	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:110146084G>C	ENST00000351050.3	-	8	1143	c.957C>G	c.(955-957)atC>atG	p.I319M		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	319					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		TGTGACTGTAGATTTCTTTGA	0.393000													13	23					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43481021	43481021	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:43481021G>A	ENST00000532038.1	-	7	1071	c.936C>T	c.(934-936)ttC>ttT	p.F312F	ARHGAP27_ENST00000455881.1_Silent_p.F193F|ARHGAP27_ENST00000532891.2_Silent_p.F512F|ARHGAP27_ENST00000582826.1_5'UTR|ARHGAP27_ENST00000528384.1_Silent_p.F166F|ARHGAP27_ENST00000428638.1_Silent_p.F534F|ARHGAP27_ENST00000376922.2_Silent_p.F193F|ARHGAP27_ENST00000442348.1_Silent_p.F507F			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	534	WW 2.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					AGTCCTTGAAGAATGTCAGGA	0.542000													42	66					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31532158	31532158	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:31532158G>A	ENST00000373747.3	-	2	355	c.256C>T	c.(256-258)Cag>Tag	p.Q86*	PUM1_ENST00000424085.2_Nonsense_Mutation_p.Q86*|PUM1_ENST00000373741.4_Nonsense_Mutation_p.Q122*|PUM1_ENST00000257075.5_Nonsense_Mutation_p.Q86*|PUM1_ENST00000440538.2_Nonsense_Mutation_p.Q86*|PUM1_ENST00000373742.2_Nonsense_Mutation_p.Q122*|PUM1_ENST00000426105.2_Nonsense_Mutation_p.Q86*|PUM1_ENST00000423018.2_Nonsense_Mutation_p.Q86*	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	86					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGCTGCCTCTGAAAGAAGTAG	0.537000													45	71					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41748804	41748804	+	Silent	SNP	T	T	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:41748804T>G	ENST00000301178.4	+	11	1519	c.1329T>G	c.(1327-1329)acT>acG	p.T443T	AXL_ENST00000593513.1_Silent_p.T175T|AXL_ENST00000359092.3_Silent_p.T434T	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	443						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						AACCTTCAACTCCTGCCTTCT	0.572000													43	82					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119121232	119121232	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:119121232G>C	ENST00000264245.4	+	10	2165	c.1633G>C	c.(1633-1635)Gag>Cag	p.E545Q		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	545					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GCTGGGAGCTGAGACTTCTGC	0.493000													19	43					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9431602	9431602	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:9431602C>T	ENST00000379719.3	+	4	590	c.448C>T	c.(448-450)Ctt>Ttt	p.L150F		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	150					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AGGAATTCTTCTTTGCCTTTA	0.373000													30	36					0	0	1	0	0
ZNF611	81856	broad.mit.edu	37	19	53209265	53209265	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:53209265C>A	ENST00000543227.1	-	6	1317	c.1043G>T	c.(1042-1044)tGt>tTt	p.C348F	ZNF611_ENST00000540744.1_Missense_Mutation_p.C348F|ZNF611_ENST00000595798.1_Missense_Mutation_p.C279F|ZNF611_ENST00000602162.1_Missense_Mutation_p.C279F|ZNF611_ENST00000319783.1_Missense_Mutation_p.C348F|ZNF611_ENST00000453741.2_Missense_Mutation_p.C279F	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		AGCCTTGTCACATTCATTACA	0.348000													48	55					4.64027e-19	4.82615e-19	1	1	0
PRMT5	10419	broad.mit.edu	37	14	23391415	23391415	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:23391415G>A	ENST00000324366.8	-	16	1954	c.1731C>T	c.(1729-1731)ttC>ttT	p.F577F	PRMT5_ENST00000397440.4_Silent_p.F406F|PRMT5_ENST00000216350.8_Silent_p.F516F|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5-AS1_ENST00000424245.2_RNA|PRMT5-AS1_ENST00000609885.1_RNA|PRMT5_ENST00000553897.1_Silent_p.F533F|PRMT5-AS1_ENST00000457443.2_RNA|PRMT5_ENST00000538452.1_Silent_p.F471F|PRMT5_ENST00000397441.2_Silent_p.F560F|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5-AS1_ENST00000599580.2_RNA	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	577					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GAAACCATGAGAACATCCCAG	0.443000													49	119					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73418865	73418865	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:73418865C>G	ENST00000339362.5	+	5	1279	c.832C>G	c.(832-834)Cca>Gca	p.P278A	NEO1_ENST00000560262.1_Missense_Mutation_p.P278A|NEO1_ENST00000261908.6_Missense_Mutation_p.P278A|NEO1_ENST00000558964.1_Missense_Mutation_p.P278A			Q92859	NEO1_HUMAN	neogenin 1	278	Ig-like C2-type 3.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						ACTTCCTACTCCAACCATTAA	0.428000													13	42					0	0	1	0	0
GNAI2	2771	broad.mit.edu	37	3	50290516	50290516	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:50290516G>C	ENST00000313601.6	+	4	748	c.364G>C	c.(364-366)Gat>Cat	p.D122H	GNAI2_ENST00000451956.1_Missense_Mutation_p.D85H|GNAI2_ENST00000536647.1_Missense_Mutation_p.D41H|GNAI2_ENST00000440628.1_Missense_Mutation_p.D70H|GNAI2_ENST00000422163.1_Missense_Mutation_p.D106H|GNAI2_ENST00000491100.1_3'UTR|GNAI2_ENST00000266027.5_Missense_Mutation_p.D106H	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	122					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		CGTGCTCCCTGATGACCTGTC	0.622000													109	164					0	0	1	0	0
BAG1	573	broad.mit.edu	37	9	33255242	33255242	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:33255242G>A	ENST00000472232.3	-	7	1099	c.1013C>T	c.(1012-1014)tCt>tTt	p.S338F	BAG1_ENST00000379704.2_Missense_Mutation_p.S223F|BAG1_ENST00000467389.2_5'UTR	NM_001172415.1|NM_004323.5	NP_001165886.1|NP_004314	Q99933	BAG1_HUMAN	BCL2-associated athanogene	338	Interaction with PPP1R15A.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(29;0.00506)			AAAGTTTGTAGACTGCAGCCG	0.562000													42	81					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56418128	56418128	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:56418128C>T	ENST00000370754.5	-	61	15368	c.15369G>A	c.(15367-15369)gtG>gtA	p.V5123V	DST_ENST00000312431.6_3'UTR|DST_ENST00000370788.2_Silent_p.V2857V|DST_ENST00000244364.6_Silent_p.V2531V|DST_ENST00000446842.2_Silent_p.V4619V|DST_ENST00000370769.4_Silent_p.V4945V|DST_ENST00000421834.2_Silent_p.V2857V|DST_ENST00000361203.3_Silent_p.V4943V			Q03001	DYST_HUMAN	dystonin	4943					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTCTTTCTTTCACCTGCTTAT	0.353000													24	47					0	0	1	0	0
ZNF22	7570	broad.mit.edu	37	10	45499096	45499096	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:45499096C>T	ENST00000298299.3	+	2	873	c.280C>T	c.(280-282)Cag>Tag	p.Q94*	CEP164P1_ENST00000456938.2_RNA	NM_006963.4	NP_008894.2	P17026	ZNF22_HUMAN	zinc finger protein 22	94					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				AAGTTTCTTTCAGAGTTCTAA	0.403000													23	40					0	0	1	0	0
EFNB1	1947	broad.mit.edu	37	X	68060482	68060482	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:68060482C>T	ENST00000204961.4	+	5	1806	c.1026C>T	c.(1024-1026)atC>atT	p.I342I		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	342					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						CGGCGAACATCTACTACAAGG	0.642000													9	5					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20066680	20066680	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:20066680C>T	ENST00000396085.1	+	14	3727	c.3366C>T	c.(3364-3366)ttC>ttT	p.F1122F	NAV2_ENST00000311043.8_Silent_p.F208F|NAV2_ENST00000527559.2_Silent_p.F1074F|NAV2_ENST00000349880.4_Silent_p.F1122F|NAV2_ENST00000540292.1_Silent_p.F1076F|NAV2_ENST00000396087.3_Silent_p.F1145F|NAV2_ENST00000533917.1_Silent_p.F208F|NAV2_ENST00000360655.4_Silent_p.F1058F|NAV2-AS2_ENST00000533767.1_RNA	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1145						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GCTTTGGGTTCAAGAAGCAGA	0.592000													29	104					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49231129	49231129	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:49231129G>A	ENST00000308025.3	-	8	880	c.801C>T	c.(799-801)ctC>ctT	p.L267L	DDX23_ENST00000553182.1_5'UTR	NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	267						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						TCCGGTCATTGAGATGTCTCG	0.502000													34	82					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4755175	4755175	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:4755175G>A	ENST00000304283.4	-	8	1083	c.789C>T	c.(787-789)gtC>gtT	p.V263V	ANKS3_ENST00000446014.2_Silent_p.V134V|ANKS3_ENST00000450067.2_Silent_p.V57V|ANKS3_ENST00000585773.1_Silent_p.V190V	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	263										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						CGTGGATGCTGACACCCTTCT	0.607000													24	83					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4889554	4889554	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4889554G>A	ENST00000361571.5	-	2	444	c.33C>T	c.(31-33)ctC>ctT	p.L11L	CAMTA2_ENST00000381311.5_Intron|CAMTA2_ENST00000414043.3_Silent_p.L11L|CAMTA2_ENST00000348066.3_5'UTR|CAMTA2_ENST00000572543.1_5'UTR|CAMTA2_ENST00000358183.4_5'UTR	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	476					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						CCCCCGGCCTGAGGGGCCGGG	0.592000													5	26					0	0	1	0	0
ZNHIT3	9326	broad.mit.edu	37	17	34849827	34849827	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:34849827C>T	ENST00000225410.4	+	4	328	c.263C>T	c.(262-264)tCt>tTt	p.S88F	ZNHIT3_ENST00000588253.1_5'UTR|ZNHIT3_ENST00000490126.2_5'UTR|ZNHIT3_ENST00000590858.1_Intron|ZNHIT3_ENST00000592616.1_Missense_Mutation_p.S88F	NM_004773.2	NP_004764.1	Q15649	ZNHI3_HUMAN	zinc finger, HIT-type containing 3	88					regulation of transcription, DNA-dependent	intracellular	metal ion binding|thyroid hormone receptor binding			lung(1)|pancreas(1)|prostate(1)	3		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0188)		GACAGAGTTTCTTTGCAGAAT	0.333000													27	52					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56481672	56481672	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:56481672C>T	ENST00000267101.3	+	6	1147	c.707C>T	c.(706-708)tCa>tTa	p.S236L	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.S177L	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	236					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GGGGGCTGCTCAGGCCCTCAG	0.547000													42	128					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983168	123983168	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:123983168G>A	ENST00000306315.5	-	4	3344	c.2909C>T	c.(2908-2910)tCt>tTt	p.S970F	ZNF608_ENST00000504926.1_Missense_Mutation_p.S543F	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	970	Ser-rich.					intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GTCCTTACTAGAAATAATATC	0.448000													33	96					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122930371	122930371	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:122930371G>A	ENST00000534624.1	-	5	1206	c.930C>T	c.(928-930)ttC>ttT	p.F310F	HSPA8_ENST00000533540.1_Silent_p.F164F|HSPA8_ENST00000532636.1_Silent_p.F310F|HSPA8_ENST00000526110.1_Silent_p.F291F|HSPA8_ENST00000534319.1_Silent_p.F74F|HSPA8_ENST00000526862.1_5'UTR|HSPA8_ENST00000453788.2_Silent_p.F310F|HSPA8_ENST00000227378.3_Silent_p.F310F	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	310	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GGGTGCCACGGAACAGGTCAG	0.488000													18	30					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12172724	12172724	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:12172724C>T	ENST00000566228.1	+	11	1423	c.1354C>T	c.(1354-1356)Ctg>Ttg	p.L452L	SNX29_ENST00000306030.3_Silent_p.L67L|SNX29_ENST00000323433.4_Silent_p.L67L	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	67					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						CGGAAGTCCTCTGAGCAGCCT	0.547000													4	10					0	0	1	0	0
HOXB5	3215	broad.mit.edu	37	17	46670827	46670827	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:46670827G>A	ENST00000239151.5	-	1	496	c.218C>T	c.(217-219)tCg>tTg	p.S73L	HOXB-AS3_ENST00000474040.1_RNA|HOXB-AS3_ENST00000480872.1_RNA|HOXB-AS3_ENST00000492897.3_RNA|HOXB-AS3_ENST00000429755.4_RNA|HOXB-AS3_ENST00000467155.2_RNA|HOXB-AS3_ENST00000487849.3_RNA|HOXB-AS3_ENST00000476204.1_RNA|HOXB3_ENST00000552000.2_Intron|HOXB-AS3_ENST00000465846.2_RNA	NM_002147.3	NP_002138.1	P09067	HXB5_HUMAN	homeobox B5	73						nucleus	sequence-specific DNA binding			large_intestine(1)|lung(2)	3						GAAGGCGCGCGAGCTCTCGCC	0.682000													8	23					0	0	1	0	0
MEX3D	399664	broad.mit.edu	37	19	1567495	1567495	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:1567495G>C	ENST00000402693.4	-	1	562	c.563C>G	c.(562-564)tCc>tGc	p.S188C	MEX3D_ENST00000388824.6_Missense_Mutation_p.S188C	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	188	KH 1.				mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACGTGCTCGGAGCTGGGCAC	0.721000													14	20					0	0	1	0	0
ZNF117	51351	broad.mit.edu	37	7	64439662	64439662	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:64439662G>A	ENST00000282869.6	-	4	1571	c.287C>T	c.(286-288)tCa>tTa	p.S96L		NM_015852.3	NP_056936.2	Q03924	ZN117_HUMAN	zinc finger protein 117							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(1)|skin(1)	22		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GTGTCTATTTGAATTTGAAAT	0.274000													12	16					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127420159	127420159	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:127420159C>T	ENST00000262461.2	+	1	702	c.513C>T	c.(511-513)ttC>ttT	p.F171F	SLC12A2_ENST00000343225.4_Silent_p.F171F	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	171					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACGTGAGCTTCCAGAACGGCG	0.662000													11	19					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													4	99					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874735	36874735	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:36874735G>T	ENST00000301807.6	-	21	6454	c.4557C>A	c.(4555-4557)tgC>tgA	p.C1519*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.C2069*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.C1519*			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2069					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAAACTCAAAGCAAGATTTGA	0.468000													18	43					2.35188e-11	2.41618e-11	1	1	0
ITIH3	3699	broad.mit.edu	37	3	52836817	52836817	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:52836817G>A	ENST00000449956.2	+	13	1710	c.1704G>A	c.(1702-1704)gaG>gaA	p.E568E	ITIH3_ENST00000416872.2_Intron	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	568					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AGCTGCTGGAGAAGCGGTGAG	0.617000													20	27					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50893124	50893124	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:50893124G>A	ENST00000380817.3	-	36	5043	c.4860C>T	c.(4858-4860)ttC>ttT	p.F1620F	SBF1_ENST00000390679.3_Silent_p.F1594F|SBF1_ENST00000348911.6_Silent_p.F1595F	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1						protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCAGTGTAGAAGTCCCACA	0.662000													29	59					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30898963	30898963	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:30898963G>A	ENST00000375712.3	+	2	1550	c.1383G>A	c.(1381-1383)gaG>gaA	p.E461E	KIF3B_ENST00000418717.2_Silent_p.E87E	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	461					anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATGCTGCCGAGATGCTGGGCG	0.502000													11	12					0	0	1	0	0
PEX3	8504	broad.mit.edu	37	6	143772190	143772190	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:143772190C>T	ENST00000367591.4	+	1	74	c.11C>T	c.(10-12)tCt>tTt	p.S4F		NM_003630.2	NP_003621.1	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	4	Targeting to peroxisomes.				protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			endometrium(1)|large_intestine(9)|lung(4)|ovary(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		ATGCTGAGGTCTGTATGGAAT	0.537000													45	239					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52317570	52317570	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:52317570C>T	ENST00000371068.5	+	4	761	c.658C>T	c.(658-660)Ctt>Ttt	p.L220F	EFHC1_ENST00000433625.2_Missense_Mutation_p.L129F|EFHC1_ENST00000538167.1_Missense_Mutation_p.L201F	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	220						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					AAAACAGCCTCTTCGTAAGTA	0.383000													35	88					0	0	1	0	0
ZNF703	80139	broad.mit.edu	37	8	37556167	37556167	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:37556167C>T	ENST00000331569.4	+	2	1977	c.1748C>T	c.(1747-1749)tCa>tTa	p.S583L		NM_025069.1	NP_079345.1	Q9H7S9	ZN703_HUMAN	zinc finger protein 703	583					adherens junction assembly|mammary gland epithelial cell differentiation|negative regulation of homotypic cell-cell adhesion|negative regulation of transcription, DNA-dependent|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of mammary gland epithelial cell proliferation|regulation of canonical Wnt receptor signaling pathway|regulation of cell cycle|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding		FGFR1/ZNF703(2)	breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)	7			BRCA - Breast invasive adenocarcinoma(5;7.93e-25)|LUSC - Lung squamous cell carcinoma(8;1.05e-09)			AGACTAGCTTCAGCCTCGGCG	0.652000													17	50					0	0	1	0	0
FAH	2184	broad.mit.edu	37	15	80464516	80464516	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:80464516G>C	ENST00000539156.1	+	7	2660	c.422G>C	c.(421-423)aGa>aCa	p.R141T	FAH_ENST00000561421.1_Missense_Mutation_p.R211T|FAH_ENST00000407106.1_Missense_Mutation_p.R211T|FAH_ENST00000261755.5_Missense_Mutation_p.R211T|FAH_ENST00000558627.1_3'UTR			P16930	FAAA_HUMAN	fumarylacetoacetate hydrolase (fumarylacetoacetase)	211					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTGGAAACAGATTGGGAGAG	0.498000									Tyrosinemia, type 1				48	57					0	0	1	0	0
ARPC4	10093	broad.mit.edu	37	3	9845655	9845655	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:9845655C>T	ENST00000397261.3	+	5	1023	c.459C>T	c.(457-459)gtC>gtT	p.V153V	ARPC4_ENST00000498623.2_Silent_p.V63V|ARPC4_ENST00000287613.7_Silent_p.V63V|ARPC4-TTLL3_ENST00000397256.1_Intron|ARPC4_ENST00000433034.1_Silent_p.V172V	NM_005718.4	NP_005709.1			actin related protein 2/3 complex, subunit 4, 20kDa											breast(1)|lung(1)	2	Medulloblastoma(99;0.227)					AGCTGTCAGTCAATGCCCGTG	0.493000													44	97					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52137213	52137213	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:52137213G>A	ENST00000596288.1	-	12	1875	c.1848C>T	c.(1846-1848)taC>taT	p.Y616Y	MCM3_ENST00000229854.7_Silent_p.Y571Y|MCM3_ENST00000419835.2_Silent_p.Y525Y	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	571					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					CCACATGGATGTACTTCTTCA	0.527000													17	51					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52171523	52171523	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:52171523C>T	ENST00000395718.2	+	6	689	c.404C>T	c.(403-405)tCt>tTt	p.S135F	FRMD6_ENST00000344768.5_Missense_Mutation_p.S143F|FRMD6_ENST00000554167.1_Missense_Mutation_p.S66F|FRMD6_ENST00000356218.4_Missense_Mutation_p.S135F	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	143	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					GTTCTTCATTCTCAGTGTGTG	0.418000													22	41					0	0	1	0	0
TSPYL1	7259	broad.mit.edu	37	6	116600489	116600489	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:116600489C>T	ENST00000368608.3	-	1	577	c.505G>A	c.(505-507)Gag>Aag	p.E169K	DSE_ENST00000540275.1_Intron	NM_003309.3	NP_003300.1	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	169					nucleosome assembly	nucleolus				breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(3)|urinary_tract(1)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CTCTCCCTCTCAGCCACGGCT	0.637000													26	37					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53946063	53946063	+	RNA	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:53946063G>C	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GCTAGAGGCTGAGAACCTTTG	0.433000													3	4					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42251519	42251519	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:42251519A>C	ENST00000341421.3	+	13	2024	c.1831A>C	c.(1831-1833)Agt>Cgt	p.S611R	TRAK1_ENST00000487159.1_Intron|TRAK1_ENST00000327628.5_Intron|TRAK1_ENST00000396175.1_Intron	NM_001265608.1|NM_014965.4	NP_001252537.1|NP_055780.2	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	0					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						AGGCAGCAGAAGTTACCCGAG	0.632000													19	62					0	0	1	0	0
RNF14	9604	broad.mit.edu	37	5	141358012	141358012	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:141358012C>T	ENST00000394520.2	+	5	760	c.451C>T	c.(451-453)Cag>Tag	p.Q151*	RNF14_ENST00000540015.1_Intron|RNF14_ENST00000347642.3_Nonsense_Mutation_p.Q151*|RNF14_ENST00000394519.1_Nonsense_Mutation_p.Q151*|RNF14_ENST00000394515.3_Intron|RNF14_ENST00000356143.1_Nonsense_Mutation_p.Q151*|RNF14_ENST00000394514.2_Nonsense_Mutation_p.Q25*|RNF14_ENST00000502341.1_3'UTR|AC005740.5_ENST00000520882.1_RNA	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	151					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GATTGGTTCTCAGAAAAAAGT	0.463000													21	30					0	0	1	0	0
CTSK	1513	broad.mit.edu	37	1	150772119	150772119	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:150772119C>T	ENST00000271651.3	-	6	795	c.685G>A	c.(685-687)Gag>Aag	p.E229K		NM_000396.3	NP_000387.1	P43235	CATK_HUMAN	cathepsin K	229					proteolysis	lysosome	cysteine-type endopeptidase activity|protein binding			cervix(1)|endometrium(1)|lung(4)|skin(1)	7	all_cancers(9;2.32e-51)|all_epithelial(9;3.89e-42)|all_lung(15;4.59e-35)|Lung NSC(24;1.7e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Colorectal(459;0.171)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCATTCCCCTCGGGGATCTCT	0.512000													6	109					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35399009	35399009	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:35399009C>G	ENST00000378495.3	+	32	4027	c.3805C>G	c.(3805-3807)Ctc>Gtc	p.L1269V	UNC13B_ENST00000378496.4_Missense_Mutation_p.L1269V|UNC13B_ENST00000396787.1_Missense_Mutation_p.L1281V|UNC13B_ENST00000481299.1_3'UTR	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1269	MHD2.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ACTCCGGCCTCTCATGGACTT	0.592000													28	43					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92268634	92268634	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:92268634G>A	ENST00000435962.2	-	4	756	c.433C>T	c.(433-435)Cct>Tct	p.P145S	TC2N_ENST00000556018.1_Missense_Mutation_p.P145S|TC2N_ENST00000340892.5_Missense_Mutation_p.P145S|TC2N_ENST00000360594.5_Missense_Mutation_p.P145S	NM_001128596.1	NP_001122068	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	145						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		GAACGGGGAGGAAAGCGTCGA	0.408000													26	64					0	0	1	0	0
CLEC4C	170482	broad.mit.edu	37	12	7894074	7894074	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:7894074C>A	ENST00000542353.1	-	4	668	c.178G>T	c.(178-180)Gag>Tag	p.E60*	CLEC4C_ENST00000540085.1_Nonsense_Mutation_p.E29*|CLEC4C_ENST00000354629.5_Nonsense_Mutation_p.E29*|CLEC4C_ENST00000360345.3_Nonsense_Mutation_p.E60*	NM_130441.2	NP_569708.1	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C	60					innate immune response	integral to membrane	sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				Kidney(36;0.0915)		TGTTGATACTCTCGTAACTTG	0.418000													42	59					3.4345e-17	3.5617e-17	1	1	0
ZNFX1	57169	broad.mit.edu	37	20	47886897	47886897	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:47886897G>A	ENST00000396105.1	-	3	1698	c.1452C>T	c.(1450-1452)ctC>ctT	p.L484L	ZNFX1_ENST00000371754.4_Silent_p.L484L|ZNFX1_ENST00000371752.1_Silent_p.L484L	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	484							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CATTGAAGCAGAGCTGGACAA	0.502000													30	102					0	0	1	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788655	140788655	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:140788655G>A	ENST00000520790.1	+	1	886	c.886G>A	c.(886-888)Gag>Aag	p.E296K	PCDHGB3_ENST00000576222.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCATTGGATGAGAAAACAGG	0.448000													35	81					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022128	14022128	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:14022128C>G	ENST00000382080.1	-	5	1223	c.508G>C	c.(508-510)Gat>Cat	p.D170H	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Missense_Mutation_p.D123H	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	157					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GTAATCTCATCTTCATCTGCA	0.413000													31	51					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229730260	229730260	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:229730260G>A	ENST00000258281.2	-	5	1719	c.1554C>T	c.(1552-1554)ttC>ttT	p.F518F	TAF5L_ENST00000366676.1_Silent_p.F518F	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	518					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				TGTCTGGACTGAAGGTGAGGC	0.577000													15	36					0	0	1	0	0
OR13D1	286365	broad.mit.edu	37	9	107457693	107457693	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:107457693G>C	ENST00000318763.5	+	1	1034	c.991G>C	c.(991-993)Gag>Cag	p.E331Q		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	331					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						AGAGGTCAAAGAGGCTGTAAA	0.408000													24	48					0	0	1	0	0
ENSA	2029	broad.mit.edu	37	1	150599891	150599891	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:150599891G>A	ENST00000356527.5	-	2	341	c.235C>T	c.(235-237)Cga>Tga	p.R79*	ENSA_ENST00000339643.5_Intron|ENSA_ENST00000503345.1_Nonsense_Mutation_p.R79*|ENSA_ENST00000361631.5_Intron|ENSA_ENST00000369014.5_Intron|ENSA_ENST00000513281.1_Intron|ENSA_ENST00000361532.5_Intron|ENSA_ENST00000369016.4_Intron|ENSA_ENST00000369009.3_Nonsense_Mutation_p.R79*|ENSA_ENST00000503241.1_Intron|ENSA_ENST00000354702.3_Intron|ENSA_ENST00000271690.8_Intron|ENSA_ENST00000362052.7_Nonsense_Mutation_p.R79*			O43768	ENSA_HUMAN	endosulfine alpha	61					cell division|G2/M transition of mitotic cell cycle|mitosis|response to nutrient|transport	cytoplasm	ion channel inhibitor activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)	4	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;9.85e-23)|all cancers(9;5.06e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.67e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000701)|LUSC - Lung squamous cell carcinoma(543;0.171)			GACTTCATTCGAAGAACCTCC	0.433000													32	151					0	0	1	0	0
IARS	3376	broad.mit.edu	37	9	95050488	95050488	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:95050488C>G	ENST00000375643.3	-	3	462	c.196G>C	c.(196-198)Gat>Cat	p.D66H	IARS_ENST00000375629.3_5'UTR|IARS_ENST00000447699.2_Intron|IARS_ENST00000443024.2_Missense_Mutation_p.D66H	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	66					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	GTAACTATATCTTTAATTGTA	0.393000													20	39					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133313612	133313612	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:133313612G>A	ENST00000539605.1	-	7	7958	c.1274C>T	c.(1273-1275)tCt>tTt	p.S425F	ANKLE2_ENST00000357997.5_Missense_Mutation_p.S487F|ANKLE2_ENST00000337516.5_Missense_Mutation_p.S487F			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	487						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GACTGGAGAAGAAGTCTCTTC	0.657000													48	57					0	0	1	0	0
CHTF18	63922	broad.mit.edu	37	16	842558	842558	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:842558C>T	ENST00000317063.6	+	12	2031	c.2031C>T	c.(2029-2031)ctC>ctT	p.L677L	CHTF18_ENST00000262315.9_Silent_p.L482L|CHTF18_ENST00000455171.2_Silent_p.L510L			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	482					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				GGGGGCTCCTCATGAGGCCCA	0.687000													14	24					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153789309	153789309	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:153789309C>A	ENST00000297107.6	+	9	1510	c.1373C>A	c.(1372-1374)gCa>gAa	p.A458E	GALNT10_ENST00000377657.3_Missense_Mutation_p.A131E|GALNT10_ENST00000377661.2_Missense_Mutation_p.A396E|SAP30L-AS1_ENST00000524264.1_RNA|SAP30L-AS1_ENST00000519727.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	458	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CCCCCGGCTGCAGCTTGGGGG	0.527000													7	130					1.12685e-05	1.14043e-05	1	1	0
NUPL2	11097	broad.mit.edu	37	7	23240296	23240296	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:23240296C>T	ENST00000258742.5	+	7	1463	c.1204C>T	c.(1204-1206)Caa>Taa	p.Q402*		NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	402	Interaction with GLE1.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGAACAATTTCAATCCAAGAA	0.353000													15	84					0	0	1	0	0
FBXW8	26259	broad.mit.edu	37	12	117448166	117448166	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:117448166G>C	ENST00000455858.2	+	8	1153	c.1080G>C	c.(1078-1080)ttG>ttC	p.L360F	FBXW8_ENST00000309909.5_Missense_Mutation_p.L426F	NM_012174.1|NM_153348.2	NP_036306.1|NP_699179.2	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8	426							protein binding	p.L426L(1)|p.L426>?(1)		endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	22	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		GCCGCCTCTTGAAGCTGGGTA	0.547000													24	59					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133174718	133174718	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:133174718C>T	ENST00000329321.3	+	1	572	c.103C>T	c.(103-105)Ctg>Ttg	p.L35L		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	35						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CACCCTTATTCTGGTGTACCT	0.547000													44	25					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23596140	23596140	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:23596140C>G	ENST00000305877.8	+	2	2185	c.1434C>G	c.(1432-1434)gtC>gtG	p.V478V	BCR_ENST00000359540.3_Silent_p.V478V	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	478					regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						ATGCGCTGGTCTCGGGAGCCC	0.667000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								17	20					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75668153	75668153	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:75668153C>G	ENST00000394947.3	-	20	3758	c.3444G>C	c.(3442-3444)aaG>aaC	p.K1148N	SIN3A_ENST00000394949.4_Missense_Mutation_p.K1148N|SIN3A_ENST00000360439.4_Missense_Mutation_p.K1148N	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	1148					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						TGTTTCCTTCCTTCCCTTCCT	0.483000													41	130					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40658093	40658093	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:40658093C>T	ENST00000454349.2	+	4	584	c.373C>T	c.(373-375)Cct>Tct	p.P125S	TNRC6B_ENST00000301923.9_Missense_Mutation_p.P161S|TNRC6B_ENST00000335727.9_Missense_Mutation_p.P125S|TNRC6B_ENST00000402203.1_Missense_Mutation_p.P161S	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	125					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						GGCAGGGCCTCCTCCCTGCAC	0.627000													3	17					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	13959967	13959967	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:13959967C>T	ENST00000382080.1	-	7	1377	c.662G>A	c.(661-663)cGt>cAt	p.R221H	SGCZ_ENST00000421524.2_Missense_Mutation_p.R174H	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	208					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTGGACCCCACGGGGAGCTTC	0.458000													11	27					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46306746	46306746	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:46306746G>A	ENST00000397850.2	-	16	2604	c.2152C>T	c.(2152-2154)Ctc>Ttc	p.L718F	ITGB2_ENST00000302347.5_Missense_Mutation_p.L718F|ITGB2_ENST00000397854.3_Missense_Mutation_p.L661F|ITGB2_ENST00000397852.1_Missense_Mutation_p.L718F|ITGB2_ENST00000355153.4_Missense_Mutation_p.L718F|ITGB2_ENST00000397857.1_Missense_Mutation_p.L718F			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	718					apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	ACCAGCAGGAGAATGCCGATC	0.597000													23	35					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3107033	3107033	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:3107033G>A	ENST00000336577.4	+	5	898		c.e5-1		RP11-473M20.7_ENST00000570949.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA|RP11-473M20.7_ENST00000573878.1_RNA|RP11-473M20.7_ENST00000572574.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25						inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						TTCTCCTGCAGACGGCGAGGG	0.657000													38	50					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44816879	44816879	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:44816879G>C	ENST00000326047.4	+	3	345	c.196G>C	c.(196-198)Gag>Cag	p.E66Q		NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	66	Kinesin-motor.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CTCCAACCCTGAGCCCAAGAC	0.443000													20	39					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230203084	230203084	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:230203084C>G	ENST00000366672.4	+	1	129	c.57C>G	c.(55-57)atC>atG	p.I19M	GALNT2_ENST00000543760.1_Intron|GALNT2_ENST00000541865.1_5'UTR	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	19					immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TGCTGGGCATCGCCTACTACA	0.766000													3	10					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136699342	136699342	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:136699342C>T	ENST00000329582.4	+	2	372	c.123C>T	c.(121-123)ctC>ctT	p.L41L	IL20RB_ENST00000484501.1_Intron|IL20RB-AS1_ENST00000462176.2_RNA|IL20RB_ENST00000309741.5_5'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	41	Fibronectin type-III 1.					integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						CTCAGAACCTCTCTGTACTCT	0.512000													49	87					0	0	1	0	0
RAD9B	144715	broad.mit.edu	37	12	110968361	110968361	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:110968361C>T	ENST00000409246.1	+	11	1266	c.941C>T	c.(940-942)tCt>tTt	p.S314F	RAD9B_ENST00000409300.1_Missense_Mutation_p.S386F|RAD9B_ENST00000409778.3_Intron|RAD9B_ENST00000392672.4_Missense_Mutation_p.S386F|RAD9B_ENST00000409425.1_Missense_Mutation_p.S314F			Q6WBX8	RAD9B_HUMAN	RAD9 homolog B (S. pombe)	383					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			endometrium(1)|large_intestine(2)|lung(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	7						GCAGTTTCTTCTGACCAGCAA	0.418000													16	53					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25457184	25457184	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:25457184G>A	ENST00000264709.3	-	23	3040	c.2703C>T	c.(2701-2703)ctC>ctT	p.L901L	DNMT3A_ENST00000380746.4_Silent_p.L712L|DNMT3A_ENST00000321117.5_Silent_p.L901L|DNMT3A_ENST00000402667.1_Silent_p.L678L	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	901					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGGAGCGAAGAGGTGGCGGA	0.517000			"""Mis, F, N, S"""		AML								38	72					0	0	1	0	0
B4GALT3	8703	broad.mit.edu	37	1	161142045	161142045	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161142045C>G	ENST00000319769.5	-	7	1102	c.880G>C	c.(880-882)Gat>Cat	p.D294H	B4GALT3_ENST00000367998.1_Missense_Mutation_p.D294H|PPOX_ENST00000495483.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000535223.1_Intron|B4GALT3_ENST00000470882.1_5'UTR	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	294					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	TTGCCCTTATCTCCTCGGTGC	0.517000													26	33					0	0	1	0	0
ANP32A	8125	broad.mit.edu	37	15	69076757	69076757	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:69076757C>T	ENST00000465139.2	-	4	648	c.505G>A	c.(505-507)Gat>Aat	p.D169N	ANP32A_ENST00000560303.1_Missense_Mutation_p.D169N|ANP32A_ENST00000483551.2_5'UTR	NM_006305.3	NP_006296.1	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	169	Asp/Glu-rich (highly acidic).|Interaction with E4F1 (By similarity).|Necessary for tumor-suppressive function.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding			endometrium(1)|large_intestine(1)|lung(2)	4						TCCTCCTCATCATCCAGGCCC	0.642000													14	28					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40035345	40035345	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:40035345G>A	ENST00000372857.3	-	5	1452	c.660C>T	c.(658-660)gtC>gtT	p.V220V	PABPC4_ENST00000372856.3_Silent_p.V220V|PABPC4_ENST00000372862.3_Silent_p.V220V|PABPC4_ENST00000529216.1_Intron|PABPC4_ENST00000372858.3_Silent_p.V220V|RP11-69E11.8_ENST00000415255.1_RNA	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	220	RRM 3.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCATCACCTTGACACTTAGGG	0.438000													17	81					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57105805	57105805	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:57105805G>A	ENST00000376149.3	-	19	2671	c.1862C>T	c.(1861-1863)tCa>tTa	p.S621L	TRIM37_ENST00000393066.3_Missense_Mutation_p.S743L|TRIM37_ENST00000262294.7_Missense_Mutation_p.S743L|TRIM37_ENST00000393065.2_Missense_Mutation_p.S709L			O94972	TRI37_HUMAN	tripartite motif containing 37	743						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GGCAACTGATGACTTTGCCAG	0.428000									Mulibrey Nanism				23	63					0	0	1	0	0
ZNF300	91975	broad.mit.edu	37	5	150282726	150282726	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:150282726C>G	ENST00000446148.2	-	4	467	c.40G>C	c.(40-42)Gag>Cag	p.E14Q	ZNF300_ENST00000418587.2_Intron|ZNF300_ENST00000394226.2_5'UTR|ZNF300_ENST00000274599.5_5'UTR|ZNF300_ENST00000427179.1_5'UTR	NM_001172831.1	NP_001166302.1	Q96RE9	ZN300_HUMAN	zinc finger protein 300	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)	27		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTTTTTGCTCTTCCAAAAGG	0.343000													24	59					0	0	1	0	0
MOGS	7841	broad.mit.edu	37	2	74689268	74689268	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:74689268G>A	ENST00000233616.4	-	4	1810	c.1648C>T	c.(1648-1650)Cag>Tag	p.Q550*	MOGS_ENST00000409065.1_3'UTR|MOGS_ENST00000452063.2_Nonsense_Mutation_p.Q444*	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	550					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						GCCTGGCTCTGATGGAGCCAG	0.602000													33	128					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50901314	50901314	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:50901314G>A	ENST00000380817.3	-	17	2136	c.1953C>T	c.(1951-1953)gtC>gtT	p.V651V	SBF1_ENST00000390679.3_Silent_p.V651V|SBF1_ENST00000348911.6_Silent_p.V652V	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1						protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGAAGGCTGTGACCAGAGGCA	0.657000													11	22					0	0	1	0	0
SPP2	6694	broad.mit.edu	37	2	234959713	234959713	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:234959713C>T	ENST00000168148.3	+	2	272	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W	SPP2_ENST00000492481.1_3'UTR|SPP2_ENST00000373368.1_Missense_Mutation_p.R62W	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	62					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		GTATCTGTTTCGGGCATTCAG	0.443000													30	19					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67816393	67816393	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:67816393G>C	ENST00000265686.3	+	14	1710	c.1602G>C	c.(1600-1602)aaG>aaC	p.K534N	TCIRG1_ENST00000532635.1_Missense_Mutation_p.K318N	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	534					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						ACTCCTTCAAGATGAAGATGT	0.627000													59	119					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154861348	154861348	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:154861348G>A	ENST00000460393.1	+	13	1425	c.1305G>A	c.(1303-1305)gaG>gaA	p.E435E	MME_ENST00000492661.1_Silent_p.E435E|MME_ENST00000493237.1_Silent_p.E435E|MME_ENST00000360490.2_Silent_p.E435E|MME_ENST00000462745.1_Silent_p.E435E	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	435					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTGCTGGAGAGAGTAAACATG	0.403000													45	80					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53217509	53217509	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:53217509C>G	ENST00000394729.2	+	8	1027	c.699C>G	c.(697-699)ttC>ttG	p.F233L	PRKCD_ENST00000330452.3_Missense_Mutation_p.F233L	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	233					activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CGCACCGCTTCAAGGTTCACA	0.572000													31	79					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117122162	117122162	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:117122162G>A	ENST00000369486.3	-	10	3951	c.3186C>T	c.(3184-3186)ctC>ctT	p.L1062L	IGSF3_ENST00000318837.6_Silent_p.L1082L|IGSF3_ENST00000369483.1_Silent_p.L1082L	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1062	Ig-like C2-type 8.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TGAGCCGGTAGAGCACCGGGG	0.642000													23	34					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49427633	49427633	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:49427633G>A	ENST00000301067.7	-	39	10854	c.10855C>T	c.(10855-10857)Ctc>Ttc	p.L3619F		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GAAGGGCTGAGAGCCAGCACA	0.612000													8	9					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56085917	56085917	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:56085917G>C	ENST00000312711.1	+	1	135	c.135G>C	c.(133-135)atG>atC	p.M45I		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					ATTTGGGCATGATTGTCCTCA	0.443000													43	118					0	0	1	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74721212	74721212	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:74721212G>C	ENST00000380494.5	-	6	1246	c.953C>G	c.(952-954)tCt>tGt	p.S318C	COL4A3BP_ENST00000261415.7_Missense_Mutation_p.S190C|COL4A3BP_ENST00000405807.4_Missense_Mutation_p.S190C	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	190					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TTCATCCTTAGAGACAGCATC	0.373000													4	69					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65945133	65945133	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:65945133G>A	ENST00000261892.6	+	9	3324	c.3037G>A	c.(3037-3039)Gat>Aat	p.D1013N	SLC24A1_ENST00000339868.6_Missense_Mutation_p.D995N|SLC24A1_ENST00000546330.1_Missense_Mutation_p.D995N|SLC24A1_ENST00000537259.1_Missense_Mutation_p.D995N|SLC24A1_ENST00000544319.2_Missense_Mutation_p.D899N|SLC24A1_ENST00000399033.4_Missense_Mutation_p.D983N|SLC24A1_ENST00000449142.2_3'UTR	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	1013					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						TAACATATTTGATATCACTGT	0.463000													24	102					0	0	1	0	0
NFE2L1	4779	broad.mit.edu	37	17	46136441	46136441	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:46136441C>T	ENST00000362042.3	+	6	2373	c.1757C>T	c.(1756-1758)tCa>tTa	p.S586L	NFE2L1_ENST00000361665.3_Missense_Mutation_p.S575L|NFE2L1_ENST00000582155.1_Missense_Mutation_p.S398L|NFE2L1_ENST00000583378.1_Missense_Mutation_p.S387L|NFE2L1_ENST00000536222.1_Missense_Mutation_p.S430L|NFE2L1_ENST00000585291.1_Missense_Mutation_p.S556L|NFE2L1_ENST00000357480.5_Missense_Mutation_p.S556L	NM_003204.2	NP_003195.1	Q14494	NF2L1_HUMAN	nuclear factor, erythroid 2-like 1	586					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			cervix(1)|endometrium(3)|kidney(9)|large_intestine(7)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCCCTGGACTCAGCCGACCTG	0.612000													39	56					0	0	1	0	0
SLC16A6	9120	broad.mit.edu	37	17	66274388	66274388	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:66274388C>T	ENST00000327268.4	-	3	238	c.74G>A	c.(73-75)tGg>tAg	p.W25*	ARSG_ENST00000448504.2_Intron|SLC16A6_ENST00000580666.1_Nonsense_Mutation_p.W25*	NM_001174166.1	NP_001167637.1	O15403	MOT7_HUMAN	solute carrier family 16, member 6	25						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			large_intestine(3)|lung(8)|prostate(1)|skin(1)|urinary_tract(2)	15	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	AGCTACCGCCCAGCCCCATCC	0.373000													34	51					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110884788	110884788	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:110884788C>T	ENST00000369784.3	+	1	3661	c.2761C>T	c.(2761-2763)Cat>Tat	p.H921Y	RBM15_ENST00000602849.1_Missense_Mutation_p.H921Y|RBM15_ENST00000487146.2_Missense_Mutation_p.H921Y	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	921	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGGGGTCCTTCATGCCTTCCC	0.527000			T	MKL1	acute megakaryocytic leukemia								43	47					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8380381	8380381	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:8380381C>T	ENST00000332175.8	+	27	4872	c.3835C>T	c.(3835-3837)Cac>Tac	p.H1279Y	PTPRM_ENST00000400060.4_Missense_Mutation_p.H1293Y|PTPRM_ENST00000580170.1_Missense_Mutation_p.H1292Y|PTPRM_ENST00000400053.4_Missense_Mutation_p.H1217Y|PTPRM_ENST00000444013.1_Missense_Mutation_p.H1066Y	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1279	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity	p.H1279Y(1)		breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CCTGGATTATCACTGCACATC	0.453000													27	36					0	0	1	0	0
C11orf48	79081	broad.mit.edu	37	11	62437356	62437356	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:62437356G>A	ENST00000431002.2	-	1	1881	c.148C>T	c.(148-150)Cag>Tag	p.Q50*	C11orf48_ENST00000532208.1_Nonsense_Mutation_p.Q50*|C11orf48_ENST00000354588.3_Nonsense_Mutation_p.Q50*			Q9BQE6	CK048_HUMAN	chromosome 11 open reading frame 48	50										endometrium(1)|lung(5)|urinary_tract(1)	7						GTACTAACCTGAATGTGCTGG	0.537000													13	56					0	0	1	0	0
ZNF473	25888	broad.mit.edu	37	19	50542477	50542477	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:50542477C>T	ENST00000595661.1	+	4	564	c.69C>T	c.(67-69)ctC>ctT	p.L23L	ZNF473_ENST00000270617.3_Silent_p.L23L|ZNF473_ENST00000391821.2_Silent_p.L23L|ZNF473_ENST00000601364.1_Silent_p.L23L|ZNF473_ENST00000445728.3_Silent_p.L11L			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	23	KRAB.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GGGAGCAGCTCGGGCTGGAAC	0.577000													44	140					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648022	130648022	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:130648022G>C	ENST00000539839.1	+	1	1019	c.437G>C	c.(436-438)gGa>gCa	p.G146A	FZD10_ENST00000229030.4_Missense_Mutation_p.E179Q	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CAGCGCGCAGGAGCACCCGCT	0.751000													9	37					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117139801	117139801	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:117139801C>G	ENST00000307564.4	-	3	447	c.286G>C	c.(286-288)Gag>Cag	p.E96Q	AKNA_ENST00000312033.3_Missense_Mutation_p.E96Q|AKNA_ENST00000374075.5_Missense_Mutation_p.E15Q|AKNA_ENST00000374088.3_Missense_Mutation_p.E96Q	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						TCCACATCCTCTGCTTCAGCC	0.552000													14	41					0	0	1	0	0
TRIM45	80263	broad.mit.edu	37	1	117663548	117663548	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:117663548G>C	ENST00000256649.4	-	1	802	c.276C>G	c.(274-276)atC>atG	p.I92M	TRIM45_ENST00000369461.3_Missense_Mutation_p.I35M|TRIM45_ENST00000369464.3_Missense_Mutation_p.I92M	NM_025188.3	NP_079464.2	Q9H8W5	TRI45_HUMAN	tripartite motif containing 45	92						cytoplasm|nucleus	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|prostate(1)	23	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		CAGGACAAAGGATGCCGATCT	0.542000													30	40					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25773850	25773850	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:25773850G>A	ENST00000428257.1	-	9	1438	c.1331C>T	c.(1330-1332)tCa>tTa	p.S444L	NGLY1_ENST00000417874.2_Missense_Mutation_p.S420L|NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000396649.3_Missense_Mutation_p.S462L|NGLY1_ENST00000467224.1_Intron|NGLY1_ENST00000280700.5_Missense_Mutation_p.S462L	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	462					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						CCAAGCCACTGACCCAGATAT	0.418000													34	77					0	0	1	0	0
EIF3D	8664	broad.mit.edu	37	22	36908628	36908628	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:36908628G>A	ENST00000216190.8	-	13	1598	c.1228C>T	c.(1228-1230)Cgt>Tgt	p.R410C	EIF3D_ENST00000541106.1_Missense_Mutation_p.R361C|EIF3D_ENST00000405442.1_Missense_Mutation_p.R410C	NM_003753.3	NP_003744.1	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3, subunit D	410						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			cervix(1)|endometrium(2)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	15						AGCTTCTGACGCCAGTCAACG	0.577000													7	67					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6605202	6605202	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:6605202C>G	ENST00000377705.5	-	4	815	c.783G>C	c.(781-783)ttG>ttC	p.L261F		NM_024654.4	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	261					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CAACAGACCTCAAGGCTAAAT	0.373000													14	65					0	0	1	0	0
IGIP	492311	broad.mit.edu	37	5	139508082	139508082	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:139508082G>C	ENST00000333305.3	+	1	2562	c.21G>C	c.(19-21)atG>atC	p.M7I		NM_001007189.1	NP_001007190.1	A6NJ69	IGIP_HUMAN	IgA-inducing protein	7						extracellular region											ATTATCACATGAAGAAACGCA	0.358000													17	43					0	0	1	0	0
ZNF562	54811	broad.mit.edu	37	19	9764312	9764312	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:9764312G>A	ENST00000448622.1	-	6	756	c.594C>T	c.(592-594)ctC>ctT	p.L198L	ZNF562_ENST00000453372.2_Silent_p.L198L|ZNF562_ENST00000590155.1_Silent_p.L197L|ZNF562_ENST00000293648.4_Silent_p.L126L|ZNF562_ENST00000453792.2_Silent_p.L129L|ZNF562_ENST00000541032.1_Silent_p.L161L|ZNF562_ENST00000537617.1_Silent_p.L82L	NM_001130031.1|NM_001130032.1	NP_001123503.1|NP_001123504.1	Q6V9R5	ZN562_HUMAN	zinc finger protein 562	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L198L(1)|p.L126L(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	17						GTCTTCCATTGAGAATTTCAA	0.398000													18	39					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58559259	58559259	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:58559259G>A	ENST00000317147.5	-	46	6940	c.6608C>T	c.(6607-6609)tCc>tTc	p.S2203F	CNOT1_ENST00000569240.1_Missense_Mutation_p.S2198F|CNOT1_ENST00000245138.4_Missense_Mutation_p.S1054F	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2203					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AGGTTCATTGGATACCTTAAA	0.468000													12	21					0	0	1	0	0
SARM1	23098	broad.mit.edu	37	17	26708656	26708656	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:26708656C>A	ENST00000457710.3	+	2	1274	c.803C>A	c.(802-804)tCg>tAg	p.S268*	TMEM199_ENST00000509083.1_3'UTR|CTB-96E2.3_ENST00000591482.1_RNA|SARM1_ENST00000379061.4_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	302					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CTTGTGGCCTCGCTGGACCCT	0.716000													6	13					0.0215528	0.0216133	1	1	0
NHLRC1	378884	broad.mit.edu	37	6	18121781	18121781	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:18121781G>A	ENST00000340650.3	-	1	1070	c.1057C>T	c.(1057-1059)Cca>Tca	p.P353S		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	353					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			TTCGGTACTGGAAACTCCTCA	0.478000													28	56					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186503736	186503736	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:186503736G>A	ENST00000323963.5	+	5	477	c.413G>A	c.(412-414)gGa>gAa	p.G138E	EIF4A2_ENST00000440191.2_Missense_Mutation_p.G139E|EIF4A2_ENST00000356531.5_Missense_Mutation_p.G43E			Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	138	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|urinary_tract(1)	28	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TGCATTGGTGGAACAAATGTT	0.413000			T	BCL6	NHL								25	61					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656098	19656098	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19656098G>A	ENST00000586018.1	+	8	2864	c.2762G>A	c.(2761-2763)cGa>cAa	p.R921Q	CILP2_ENST00000291495.5_Missense_Mutation_p.R915Q			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	915						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GTCCCCTTCCGAGAGGGCACA	0.672000													11	34					0	0	1	0	0
SRRM1	10250	broad.mit.edu	37	1	24987249	24987249	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:24987249C>T	ENST00000323848.9	+	10	1670	c.1355C>T	c.(1354-1356)tCa>tTa	p.S452L	SRRM1_ENST00000374389.4_Missense_Mutation_p.S447L|SRRM1_ENST00000537199.1_3'UTR|SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000447431.2_Missense_Mutation_p.S450L	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	452	Arg-rich.|Necessary for speckles and matrix localization.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		GAATCCCCTTCACCAGCACCG	0.328000													19	65					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424800	91424800	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:91424800C>T	ENST00000268171.3	+	16	2356	c.2077C>T	c.(2077-2079)Cgg>Tgg	p.R693W		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	693	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCAGCCACCTCGGCTGCCCCC	0.711000													18	17					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136594118	136594118	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:136594118C>T	ENST00000264162.2	-	1	632	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	208	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCATAGCTTTCGTGGTAAATC	0.507000													67	31					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10438398	10438398	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:10438398G>A	ENST00000245503.5	-	19	2556	c.2172C>T	c.(2170-2172)ttC>ttT	p.F724F	MYH2_ENST00000532183.2_Intron|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Silent_p.F724F|RP11-799N11.1_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	724	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ACCTCTGTTTGAAGTCTGCAT	0.413000													46	23					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72289754	72289754	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:72289754C>G	ENST00000550746.1	+	9	998	c.934C>G	c.(934-936)Caa>Gaa	p.Q312E	TBC1D15_ENST00000319106.8_Missense_Mutation_p.Q303E|TBC1D15_ENST00000485960.2_Missense_Mutation_p.Q295E|TBC1D15_ENST00000393309.3_Missense_Mutation_p.Q66E	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	312							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCCTGTTGTTCAAAGGAGAGA	0.318000													17	22					0	0	1	0	0
EVI2B	2124	broad.mit.edu	37	17	29632419	29632419	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:29632419G>C	ENST00000330927.4	-	2	363	c.209C>G	c.(208-210)tCa>tGa	p.S70*	NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron|EVI2B_ENST00000577894.1_Nonsense_Mutation_p.S70*|EVI2B_ENST00000544462.1_Nonsense_Mutation_p.S85*|CTD-2370N5.3_ENST00000578584.1_3'UTR	NM_006495.3	NP_006486.3	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	70						cytoplasm|integral to plasma membrane		p.0?(8)|p.?(3)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	12		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		AGGTGATATTGATTGTCCAGA	0.438000													53	159					0	0	1	0	0
HNRNPK	3190	broad.mit.edu	37	9	86586216	86586216	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:86586216G>A	ENST00000376263.3	-	13	1287	c.1064C>T	c.(1063-1065)tCa>tTa	p.S355L	HNRNPK_ENST00000376281.4_Missense_Mutation_p.S355L|HNRNPK_ENST00000351839.3_Missense_Mutation_p.S355L|HNRNPK_ENST00000376264.2_Missense_Mutation_p.S355L|HNRNPK_ENST00000360384.5_Missense_Mutation_p.S355L	NM_031263.2	NP_112553.1	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	355	2 X 22 AA approximate repeats.|5 X 4 AA repeats of G-X-G-G.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|stomach(1)	19						CTGCCATTCTGATGGGCTCCA	0.388000													39	69					0	0	1	0	0
TEAD1	7003	broad.mit.edu	37	11	12958691	12958691	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:12958691C>G	ENST00000361905.4	+	13	1823	c.1158C>G	c.(1156-1158)ctC>ctG	p.L386L	TEAD1_ENST00000527636.1_Silent_p.L401L|TEAD1_ENST00000527575.1_Silent_p.L343L|TEAD1_ENST00000334310.6_Silent_p.L332L|TEAD1_ENST00000526600.1_Silent_p.L305L|TEAD1_ENST00000361985.2_Silent_p.L401L	NM_021961.5	NP_068780.2	P28347	TEAD1_HUMAN	TEA domain family member 1 (SV40 transcriptional enhancer factor)	401	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)	17				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		AAACTCTACTCTGCATGGCCT	0.338000													21	28					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62289010	62289010	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:62289010G>C	ENST00000378024.4	-	5	13153	c.12879C>G	c.(12877-12879)atC>atG	p.I4293M	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4293					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGGGCCCTTGATGTCAACTT	0.507000													107	142					0	0	1	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033278	37033278	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:37033278G>A	ENST00000322716.5	-	1	1517	c.1291C>T	c.(1291-1293)Cta>Tta	p.L431L		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	431						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						AAGTCTGTTAGATTTTTTTCC	0.338000													16	37					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328561	57328561	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:57328561C>G	ENST00000326441.9	-	10	1612	c.1249G>C	c.(1249-1251)Gaa>Caa	p.E417Q	PEG3_ENST00000423103.2_Missense_Mutation_p.E417Q|PEG3_ENST00000593695.1_Missense_Mutation_p.E291Q|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E293Q|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	417					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTACCACATTCAAAGGGCTTC	0.493000													33	132					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19080529	19080529	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:19080529C>T	ENST00000380502.3	-	9	1479	c.1012G>A	c.(1012-1014)Gaa>Aaa	p.E338K	HAUS6_ENST00000380496.1_Missense_Mutation_p.E202K	NM_001270890.1|NM_017645.4	NP_001257819.1|NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	338					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GTCTCTTTTTCAAGGTAGTGA	0.363000													16	29					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149767531	149767531	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:149767531G>A	ENST00000451292.1	+	19	3145	c.3037G>A	c.(3037-3039)Gca>Aca	p.A1013T	TCOF1_ENST00000513346.1_Missense_Mutation_p.A1013T|TCOF1_ENST00000439160.2_Missense_Mutation_p.A976T|TCOF1_ENST00000504761.2_Missense_Mutation_p.A976T|TCOF1_ENST00000323668.7_Missense_Mutation_p.A899T|TCOF1_ENST00000445265.2_Missense_Mutation_p.A899T|TCOF1_ENST00000377797.3_Missense_Mutation_p.A976T			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	976					skeletal system development	nucleolus	protein binding|transporter activity	p.A899T(2)|p.A976T(1)		NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCTACACCCGCACAAGCCCA	0.587000													4	100					0	0	1	0	0
C2orf44	80304	broad.mit.edu	37	2	24261791	24261791	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:24261791G>A	ENST00000295148.4	-	2	631	c.574C>T	c.(574-576)Cac>Tac	p.H192Y	C2orf44_ENST00000406895.3_Missense_Mutation_p.H192Y	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	192							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGCACCTGTGAAGAGTCTTC	0.537000			T	ALK	NSCLC								33	37					0	0	1	0	0
PPM1N	147699	broad.mit.edu	37	19	46002205	46002205	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:46002205G>A	ENST00000324688.4	+	1	341	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	PPM1N_ENST00000396737.2_Intron|PPM1N_ENST00000451287.2_Missense_Mutation_p.E159K|PPM1N_ENST00000401705.1_Intron|PPM1N_ENST00000456399.2_Intron			Q8N819	PPM1N_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)	159	PP2C-like.						magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)	9						GCCCCGCGTGGAAACGGGCGG	0.751000													4	3					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79225138	79225138	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:79225138G>C	ENST00000288439.5	-	14	2565	c.2220C>G	c.(2218-2220)ttC>ttG	p.F740L	SLC38A10_ENST00000374759.3_Intron	NM_138570.2	NP_612637.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	0					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GAAGGGAGCAGAAAGCTCTCC	0.592000													29	41					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40800815	40800815	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:40800815C>T	ENST00000381782.2	+	10	1789	c.1294C>T	c.(1294-1296)Caa>Taa	p.Q432*	NSUN7_ENST00000316607.5_Nonsense_Mutation_p.Q432*	NM_024677.4	NP_078953			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						TACTAAAGCTCAAGCAGTTGT	0.333000													6	30					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40559035	40559035	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:40559035C>T	ENST00000333229.2	-	42	7207	c.6880G>A	c.(6880-6882)Gaa>Aaa	p.E2294K		NM_018963.4	NP_061836.2	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	2294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTTTCACTTTCAGAATTTATG	0.348000													25	21					0	0	1	0	0
ZNF195	7748	broad.mit.edu	37	11	3380466	3380466	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:3380466G>A	ENST00000354599.6	-	4	1660	c.1556C>T	c.(1555-1557)tCa>tTa	p.S519L	ZNF195_ENST00000526601.1_Missense_Mutation_p.S572L|ZNF195_ENST00000528796.1_Intron|ZNF195_ENST00000399602.4_Missense_Mutation_p.S591L|ZNF195_ENST00000005082.9_Missense_Mutation_p.S568L|ZNF195_ENST00000429541.2_Missense_Mutation_p.S523L|ZNF195_ENST00000343338.7_Missense_Mutation_p.S523L	NM_001242843.1|NM_001256825.1|NM_007152.4	NP_001229772.1|NP_001243754.1|NP_009083.2	O14628	ZN195_HUMAN	zinc finger protein 195	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)	17		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		AATAAGGTTTGAGGACTGGGT	0.408000													17	59					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418524	105418524	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:105418524A>T	ENST00000333244.5	-	7	3383	c.3264T>A	c.(3262-3264)agT>agA	p.S1088R	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1088						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCATCTTGAAACTGGGCATCT	0.627000													9	376					0	0	1	0	0
YARS2	51067	broad.mit.edu	37	12	32903720	32903720	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:32903720G>A	ENST00000324868.8	-	3	1063	c.1036C>T	c.(1036-1038)Cag>Tag	p.Q346*		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	346					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	AGTCGTTTCTGAGGACCCCGC	0.438000													27	57					0	0	1	0	0
COQ10B	80219	broad.mit.edu	37	2	198338485	198338485	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:198338485C>G	ENST00000263960.2	+	5	692	c.554C>G	c.(553-555)tCt>tGt	p.S185C	COQ10B_ENST00000409398.1_Missense_Mutation_p.S135C|COQ10B_ENST00000545340.1_Missense_Mutation_p.S142C|COQ10B_ENST00000409010.1_Missense_Mutation_p.S157C	NM_025147.3	NP_079423.1	Q9H8M1	CQ10B_HUMAN	coenzyme Q10 homolog B (S. cerevisiae)	185						mitochondrial inner membrane				endometrium(1)|large_intestine(2)|lung(3)	6			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTACAGATTTCTTTTGAATTT	0.343000													9	7					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19106032	19106032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19106032G>A	ENST00000601879.1	-	9	3346	c.3049C>T	c.(3049-3051)Cag>Tag	p.Q1017*	SUGP2_ENST00000452918.2_Nonsense_Mutation_p.Q1017*|SUGP2_ENST00000337018.6_Nonsense_Mutation_p.Q1017*|SUGP2_ENST00000600377.1_Nonsense_Mutation_p.Q1031*|SUGP2_ENST00000456085.2_Nonsense_Mutation_p.Q786*			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	1017	G-patch.				mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						TGCAGCATCTGGAAGCCCAGG	0.617000													15	30					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42763227	42763227	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:42763227C>T	ENST00000261491.5	+	15	1715	c.1694C>T	c.(1693-1695)tCc>tTc	p.S565F	DGKH_ENST00000379274.2_Missense_Mutation_p.S429F|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000337343.4_Missense_Mutation_p.S565F|DGKH_ENST00000536612.1_Missense_Mutation_p.S429F|DGKH_ENST00000538674.1_Missense_Mutation_p.S320F|DGKH_ENST00000540693.1_Missense_Mutation_p.S565F	NM_152910.4	NP_690874.2	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CACACAGATTCCCAGGCTGCG	0.488000													33	18					0	0	1	0	0
CCND1	595	broad.mit.edu	37	11	69462886	69462886	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:69462886C>T	ENST00000227507.2	+	4	926	c.699C>T	c.(697-699)ctC>ctT	p.L233L	CCND1_ENST00000536559.1_3'UTR	NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	233					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	CACGCTTCCTCTCCAGAGTGA	0.622000			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			146	50					0	0	1	0	0
UCN3	114131	broad.mit.edu	37	10	5415749	5415749	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:5415749C>T	ENST00000380433.3	+	2	294	c.66C>T	c.(64-66)ctC>ctT	p.L22L		NM_053049.2	NP_444277.2	Q969E3	UCN3_HUMAN	urocortin 3	22						extracellular region	hormone activity			endometrium(1)|large_intestine(1)	2						GGACAGGCCTCCCCCACAAGT	0.622000													36	62					0	0	1	0	0
PTAFR	5724	broad.mit.edu	37	1	28476798	28476798	+	Silent	SNP	G	G	A	rs144798109	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:28476798G>A	ENST00000373857.3	-	2	1369	c.735C>T	c.(733-735)ttC>ttT	p.F245F	PTAFR_ENST00000305392.3_Silent_p.F245F|PTAFR_ENST00000539896.1_Silent_p.F245F	NM_000952.4|NM_001164722.2|NM_001164723.2	NP_000943.1|NP_001158194.1|NP_001158195.1	P25105	PTAFR_HUMAN	platelet-activating factor receptor	245					chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|stomach(1)	15		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGGGGCACGAAGCAGATGA	0.612000													19	38					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200954082	200954082	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:200954082G>A	ENST00000332129.2	-	27	4024	c.3708C>T	c.(3706-3708)ttC>ttT	p.F1236F	KIF21B_ENST00000360529.5_Silent_p.F1236F|KIF21B_ENST00000461742.2_Silent_p.F1236F|KIF21B_ENST00000422435.2_Silent_p.F1236F	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1236					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						ATGGGGGTGTGAATCCCACAT	0.602000													8	38					0	0	1	0	0
SLC30A4	7782	broad.mit.edu	37	15	45782984	45782984	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:45782984C>T	ENST00000261867.4	-	4	948	c.634G>A	c.(634-636)Gaa>Aaa	p.E212K	RP11-519G16.3_ENST00000560647.1_RNA|RP11-519G16.3_ENST00000558536.1_RNA	NM_013309.4	NP_037441.2	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter), member 4	212					regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(1)|stomach(1)	15		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		CCATTTATTTCATAGTTCATA	0.343000													9	18					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35940500	35940500	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:35940500C>T	ENST00000325722.3	-	5	1155	c.921G>A	c.(919-921)aaG>aaA	p.K307K		NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	307						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCACCAGTTCCTTTATAACTG	0.363000													15	19					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40542233	40542233	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:40542233G>C	ENST00000434248.1	-	5	598	c.533C>G	c.(532-534)tCa>tGa	p.S178*	ZNF780B_ENST00000221355.6_Nonsense_Mutation_p.S30*	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AATAAGATTTGAACCACAACT	0.353000													22	79					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110146645	110146645	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:110146645G>A	ENST00000351050.3	-	7	988	c.802C>T	c.(802-804)Ctc>Ttc	p.L268F		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	268					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		TTCTTGTTGAGAAAGAGGACA	0.393000													30	29					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17895674	17895674	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:17895674G>C	ENST00000594202.1	+	26	2646	c.2367G>C	c.(2365-2367)caG>caC	p.Q789H	FCHO1_ENST00000596951.1_Missense_Mutation_p.Q789H|FCHO1_ENST00000595033.1_Missense_Mutation_p.Q739H|FCHO1_ENST00000389133.4_Missense_Mutation_p.Q789H|FCHO1_ENST00000600676.1_Missense_Mutation_p.Q789H|FCHO1_ENST00000539407.1_Missense_Mutation_p.Q789H|FCHO1_ENST00000596536.1_Missense_Mutation_p.Q789H|FCHO1_ENST00000252771.7_Missense_Mutation_p.Q789H|FCHO1_ENST00000597512.1_Missense_Mutation_p.Q796H	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	789										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CGAACGTCCAGATCCTGCTGC	0.657000											OREG0025350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	111					0	0	1	0	0
UBTD2	92181	broad.mit.edu	37	5	171661337	171661337	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:171661337C>G	ENST00000393792.2	-	2	501	c.96G>C	c.(94-96)ttG>ttC	p.L32F		NM_152277.2	NP_689490.2	Q8WUN7	UBTD2_HUMAN	ubiquitin domain containing 2	32						cytoplasm				cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)|skin(1)	10	Renal(175;0.000159)|Lung NSC(126;0.00976)|all_lung(126;0.0156)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTCCTTTTTCAAAGGCTGGT	0.368000													22	47					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	356019	356019	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:356019G>A	ENST00000280886.6	-	32	4025	c.3938C>T	c.(3937-3939)cCt>cTt	p.P1313L		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1313						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGTTGGGTCAGGTCCTGAGGT	0.438000													18	54					0	0	1	0	0
CDK9	1025	broad.mit.edu	37	9	130549879	130549879	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:130549879G>A	ENST00000373265.2	+	3	608	c.608G>A	c.(607-609)cGa>cAa	p.R203Q	CDK9_ENST00000480353.1_3'UTR|CDK9_ENST00000373264.4_Missense_Mutation_p.R86Q			P50750	CDK9_HUMAN	cyclin-dependent kinase 9	86	Protein kinase.				cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						GAGATTTGTCGAACCAAAGGT	0.433000													37	74					0	0	1	0	0
ACER3	55331	broad.mit.edu	37	11	76670067	76670067	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:76670067G>A	ENST00000532485.1	+	3	363	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	ACER3_ENST00000533873.1_Missense_Mutation_p.E50K|ACER3_ENST00000526597.1_Intron|CTD-2547H18.1_ENST00000530190.1_RNA|ACER3_ENST00000538157.1_Missense_Mutation_p.E45K|ACER3_ENST00000530182.1_3'UTR	NM_018367.5	NP_060837.3	Q9NUN7	ACER3_HUMAN	alkaline ceramidase 3	87					ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)	9						TCTGAAATATGAAATGCAGGT	0.338000													14	20					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													4	152					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91169124	91169124	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:91169124C>T	ENST00000420329.2	+	10	1013	c.866C>T	c.(865-867)tCc>tTc	p.S289F	RP11-387D10.2_ENST00000559531.1_RNA|CRTC3_ENST00000268184.6_Missense_Mutation_p.S289F	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	289					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CTGCCAGCCTCCCTGGACACC	0.547000			T	MAML2	salivary gland mucoepidermoid								98	396					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1584638	1584638	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:1584638C>G	ENST00000590550.2	-	2	514	c.141G>C	c.(139-141)caG>caC	p.Q47H	MBD3_ENST00000434436.3_Missense_Mutation_p.Q103H|UQCR11_ENST00000585937.1_3'UTR|MBD3_ENST00000156825.1_Missense_Mutation_p.Q103H|MBD3_ENST00000585967.1_5'UTR|MBD3_ENST00000592012.1_Missense_Mutation_p.Q71H			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	103	MBD.				transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGACGCCGTCTGGCGCACGG	0.697000													24	37					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420747	105420747	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:105420747C>T	ENST00000333244.5	-	7	1160	c.1041G>A	c.(1039-1041)caG>caA	p.Q347Q		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	347						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCACCCCACTCTGGAACCCCC	0.667000													17	30					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65119214	65119214	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:65119214G>C	ENST00000358691.5	-	26	3668	c.3502C>G	c.(3502-3504)Ctt>Gtt	p.L1168V	HELZ_ENST00000580168.1_Missense_Mutation_p.L1169V	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGAGGTCCAAGAGGGGGTGGA	0.433000													33	47					0	0	1	0	0
TDO2	6999	broad.mit.edu	37	4	156828902	156828902	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:156828902C>T	ENST00000536354.2	+	4	325	c.261C>T	c.(259-261)ctC>ctT	p.L87L		NM_005651.3	NP_005642.1	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	87					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	18	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	AGCAAATCCTCTGGGAGTTGG	0.348000													17	35					0	0	1	0	0
TFPT	29844	broad.mit.edu	37	19	54618048	54618048	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:54618048G>A	ENST00000391759.1	-	2	461	c.56C>T	c.(55-57)tCa>tTa	p.S19L	TFPT_ENST00000391758.1_Missense_Mutation_p.S10L|TFPT_ENST00000391757.1_Missense_Mutation_p.S19L	NM_013342.3	NP_037474.1	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner (in childhood Leukemia)	19					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding			large_intestine(2)|lung(2)	4	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					TGGCGGCGCTGAGAACTCCTC	0.627000			T	TCF3	pre-B ALL								94	241					0	0	1	0	0
AVPI1	60370	broad.mit.edu	37	10	99437765	99437765	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:99437765G>A	ENST00000370626.3	-	3	872	c.305C>T	c.(304-306)tCt>tTt	p.S102F		NM_021732.2	NP_068378.2	Q5T686	AVPI1_HUMAN	arginine vasopressin-induced 1	102					cell cycle					breast(1)|endometrium(1)|large_intestine(2)|skin(1)	5		Colorectal(252;0.162)		Epithelial(162;8.37e-11)|all cancers(201;7.94e-09)		GGCCAGTGCAGAGTGGGGCTC	0.517000													32	19					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71836033	71836033	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:71836033C>T	ENST00000377245.4	+	5	781	c.573C>T	c.(571-573)ctC>ctT	p.L191L	TJP2_ENST00000539225.1_Silent_p.L222L|TJP2_ENST00000535702.1_Silent_p.L195L|TJP2_ENST00000348208.4_Silent_p.L191L|TJP2_ENST00000453658.2_Silent_p.L168L|TJP2_ENST00000265384.7_Silent_p.L191L	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	191					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						AGCGGGACCTCAGCCGGGACC	0.771000													5	7					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41798738	41798738	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:41798738G>A	ENST00000396930.3	-	16	3204	c.2661C>T	c.(2659-2661)ctC>ctT	p.L887L	KAT6A_ENST00000265713.2_Silent_p.L887L|KAT6A_ENST00000406337.1_Silent_p.L887L	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	887					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCTCTTCCAAGAGCAGTTTAG	0.483000													27	39					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46620663	46620663	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:46620663G>A	ENST00000330070.4	-	2	2005	c.838C>T	c.(838-840)Cgc>Tgc	p.R280C		NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	280					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						CCGGCCCCGCGCAGCGCGCAG	0.711000													15	35					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323278	31323278	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:31323278G>A	ENST00000265071.2	+	12	2501	c.2236G>A	c.(2236-2238)Gtg>Atg	p.V746M		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	746					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CACTGGCTCCGTGGCGGATTC	0.517000													27	46					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62295136	62295136	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:62295136G>A	ENST00000378024.4	-	5	7027	c.6753C>T	c.(6751-6753)ttC>ttT	p.F2251F	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2251					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CAGGCATGCTGAACTTGGGCA	0.527000													164	251					0	0	1	0	0
METTL23	124512	broad.mit.edu	37	17	74729258	74729258	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:74729258G>C	ENST00000588783.1	+	3	640	c.283G>C	c.(283-285)Gat>Cat	p.D95H	METTL23_ENST00000590964.1_Missense_Mutation_p.D28H|METTL23_ENST00000588302.1_Missense_Mutation_p.D28H|METTL23_ENST00000591571.1_Missense_Mutation_p.D28H|METTL23_ENST00000341249.6_Missense_Mutation_p.D95H|METTL23_ENST00000586738.1_Missense_Mutation_p.D95H|METTL23_ENST00000588822.1_Missense_Mutation_p.D28H|METTL23_ENST00000586752.1_Missense_Mutation_p.D28H|METTL23_ENST00000586200.1_Intron|METTL23_ENST00000589977.1_Missense_Mutation_p.D95H|RP11-318A15.7_ENST00000587459.1_Missense_Mutation_p.D67H	NM_001080510.3|NM_001206983.1	NP_001073979.3|NP_001193912.1	Q86XA0	MET23_HUMAN	methyltransferase like 23	95						integral to membrane	methyltransferase activity			large_intestine(2)|lung(1)	3						ACCACCACAAGATATTATCCT	0.418000													14	17					0	0	1	0	0
TBC1D7	51256	broad.mit.edu	37	6	13307937	13307937	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:13307937C>T	ENST00000607658.1	-	5	629	c.479G>A	c.(478-480)aGa>aAa	p.R160K	TBC1D7_ENST00000607532.1_5'UTR|TBC1D7_ENST00000343141.4_Missense_Mutation_p.R141K|TBC1D7_ENST00000379307.2_Missense_Mutation_p.R160K|TBC1D7_ENST00000356436.4_Missense_Mutation_p.R187K|TBC1D7_ENST00000379300.3_Missense_Mutation_p.R187K			Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7	187	Rab-GAP TBC.				positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			AGTCAGCAGTCTGCCATCTTC	0.418000													15	48					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172582534	172582534	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:172582534C>G	ENST00000534253.2	+	9	881	c.713C>G	c.(712-714)tCt>tGt	p.S238C	DYNC1I2_ENST00000409197.1_Missense_Mutation_p.S212C|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.S230C|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.S232C|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.S238C|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.S232C|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.S212C|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.S212C|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.S230C|DYNC1I2_ENST00000397119.3_Missense_Mutation_p.S238C|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.S238C			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	238					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			AGAGCTCTTTCTGAGCAGATT	0.343000													14	4					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43385641	43385641	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:43385641G>A	ENST00000372851.3	-	5	555	c.489C>T	c.(487-489)atC>atT	p.I163I	RIMS4_ENST00000541604.2_Silent_p.I164I	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	163	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				TGGCAATGCAGATGCCATTCT	0.562000													171	284					0	0	1	0	0
SLC22A23	63027	broad.mit.edu	37	6	3287119	3287119	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:3287119G>A	ENST00000436008.2	-	7	1982	c.1520C>T	c.(1519-1521)tCa>tTa	p.S507L	PSMG4_ENST00000451246.2_Intron|SLC22A23_ENST00000490273.1_Missense_Mutation_p.S226L|SLC22A23_ENST00000406686.3_Missense_Mutation_p.S507L|SLC22A23_ENST00000380302.4_Missense_Mutation_p.S226L			A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23	507					ion transport	integral to membrane	transmembrane transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				CTGCAGGAGTGAGGCCAGGGC	0.662000													9	16					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57857008	57857008	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:57857008C>T	ENST00000381227.1	+	4	600	c.187C>T	c.(187-189)Cct>Tct	p.P63S	POLR2B_ENST00000431623.2_Intron|POLR2B_ENST00000314595.5_Missense_Mutation_p.P63S|POLR2B_ENST00000441246.2_Missense_Mutation_p.P56S			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	63					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					GGAAGACGCTCCTCCTATAGA	0.423000													11	33					0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74493622	74493622	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:74493622G>A	ENST00000422840.2	-	23	3101	c.3102C>T	c.(3100-3102)ctC>ctT	p.L1034L	GLG1_ENST00000447066.2_Silent_p.L1023L|GLG1_ENST00000205061.5_Silent_p.L1034L	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	1034						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						GGTTGACCTTGAGGCACTCCT	0.438000													10	18					0	0	1	0	0
NFATC2IP	84901	broad.mit.edu	37	16	28967613	28967613	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:28967613C>T	ENST00000320805.4	+	5	876	c.801C>T	c.(799-801)ctC>ctT	p.L267L	NFATC2IP_ENST00000562977.1_Intron|NFATC2IP_ENST00000564978.1_Intron	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	267						cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						TCTTCCCACTCAAAATCCGTT	0.617000													18	27					0	0	1	0	0
MED10	84246	broad.mit.edu	37	5	6378486	6378486	+	Silent	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:6378486G>T	ENST00000255764.3	-	1	221	c.111C>A	c.(109-111)ctC>ctA	p.L37L		NM_032286.2	NP_115662.2	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	37					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				kidney(1)|large_intestine(1)|ovary(1)|prostate(1)|urinary_tract(1)	5						GCTTTTGGTTGAGCCCGGCCT	0.652000													12	20					3.07112e-06	3.11695e-06	1	1	0
FSCB	84075	broad.mit.edu	37	14	44974070	44974070	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:44974070G>A	ENST00000340446.4	-	1	2412	c.2121C>T	c.(2119-2121)gtC>gtT	p.V707V		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	707						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CTTCTGCAGGGACATCATCAG	0.537000													9	31					0	0	1	0	0
NR2F6	2063	broad.mit.edu	37	19	17343275	17343275	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:17343275G>A	ENST00000291442.3	-	4	1820	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L		NM_005234.3	NP_005225.2	P10588	NR2F6_HUMAN	nuclear receptor subfamily 2, group F, member 6	367	Important for dimerization (By similarity).|Ligand-binding (By similarity).				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						GCTGGGAGATGAGGGAGGCAG	0.667000													22	34					0	0	1	0	0
CDK1	983	broad.mit.edu	37	10	62545481	62545481	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:62545481T>C	ENST00000448257.2	+	4	455	c.254T>C	c.(253-255)aTg>aCg	p.M85T	CDK1_ENST00000395284.3_Missense_Mutation_p.M85T|CDK1_ENST00000316629.4_Missense_Mutation_p.M85T|CDK1_ENST00000373809.2_Missense_Mutation_p.M85T			P06493	CDK1_HUMAN	cyclin-dependent kinase 1	85	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						TTTCTTTCCATGGATCTGAAG	0.348000													46	104					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55920859	55920859	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:55920859G>T	ENST00000447944.2	-	1	186	c.100C>A	c.(100-102)Caa>Aaa	p.Q34K		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	34					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCTCGCACTTGCAACTGGGTG	0.612000													46	97					4.21674e-32	4.4049e-32	1	1	0
PRELID1	27166	broad.mit.edu	37	5	176731776	176731776	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:176731776G>A	ENST00000303204.4	+	2	455	c.243G>A	c.(241-243)ctG>ctA	p.L81L	PRELID1_ENST00000502670.1_3'UTR|PRELID1_ENST00000503216.1_Silent_p.L81L			Q9Y255	PRLD1_HUMAN	PRELI domain containing 1	81	PRELI/MSF1.				immune response|multicellular organismal development	mitochondrion|nucleus				endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	7	all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTACGTCCTGGAGGACTCTA	0.552000													20	29					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63988351	63988351	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:63988351C>A	ENST00000443617.2	-	27	5180	c.5093G>T	c.(5092-5094)gGa>gTa	p.G1698V	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1698					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GCCACTCTCTCCCTTGCCTCC	0.458000													10	12					6.40141e-05	6.46479e-05	1	1	0
ZNF468	90333	broad.mit.edu	37	19	53345155	53345155	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:53345155G>T	ENST00000595646.1	-	4	512	c.392C>A	c.(391-393)gCt>gAt	p.A131D	ZNF468_ENST00000390651.4_Missense_Mutation_p.A78D|ZNF468_ENST00000396409.4_Missense_Mutation_p.A78D|ZNF468_ENST00000243639.4_3'UTR|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		CTTGTTTCCAGCATGCCTTTG	0.423000													5	293					1	1	1	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14852240	14852240	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:14852240C>T	ENST00000358984.4	+	36	4120	c.3940C>T	c.(3940-3942)Cga>Tga	p.R1314*		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1399										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TAGGTGGCTTCGACAGCAATT	0.348000													3	4					0	0	1	0	0
BRMS1	25855	broad.mit.edu	37	11	66108686	66108686	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:66108686G>A	ENST00000359957.3	-	4	509	c.349C>T	c.(349-351)Cag>Tag	p.Q117*	BRMS1_ENST00000425825.2_Nonsense_Mutation_p.Q117*	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	117					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						CCTGCCACCTGAATGCGAATC	0.642000													44	59					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2815189	2815189	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:2815189C>T	ENST00000301740.8	+	11	5209	c.4660C>T	c.(4660-4662)Cag>Tag	p.Q1554*		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1554	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						TGCATCCCCTCAGGAAAGAAG	0.512000													21	58					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20582438	20582438	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:20582438G>A	ENST00000202677.7	-	16	2098	c.2091C>T	c.(2089-2091)ctC>ctT	p.L697L	RALGAPA2_ENST00000495793.1_5'UTR	NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)						activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						TCCGCCAGCTGAGAGAAAAGG	0.478000													25	29					0	0	1	0	0
LIMD1	8994	broad.mit.edu	37	3	45636841	45636841	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:45636841C>T	ENST00000273317.4	+	1	491	c.470C>T	c.(469-471)tCt>tTt	p.S157F	LIMD1_ENST00000440097.1_Missense_Mutation_p.S157F|LIMD1_ENST00000465039.1_Intron	NM_014240.2	NP_055055.1	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	157					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		CTGGCGACTTCTGAGATGTCT	0.597000													48	61					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42922574	42922574	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:42922574C>T	ENST00000372561.3	+	1	345	c.338C>T	c.(337-339)tCg>tTg	p.S113L	PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000372556.3_Intron|PPCS_ENST00000372562.1_Intron|PPCS_ENST00000372560.3_Missense_Mutation_p.S113L|PPCS_ENST00000455780.1_Intron	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	113					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCAGCCCTTTCGGGCTTGCTG	0.647000													71	92					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	46008455	46008455	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:46008455G>A	ENST00000296137.2	-	8	2576	c.2371C>T	c.(2371-2373)Cag>Tag	p.Q791*	FYCO1_ENST00000535325.1_Nonsense_Mutation_p.Q791*	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	791					transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TCCACCACCTGAGCCTGCAGC	0.642000													26	49					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212553308	212553308	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:212553308C>G	ENST00000261455.4	-	5	704	c.567G>C	c.(565-567)ctG>ctC	p.L189L	TMEM206_ENST00000535273.1_Silent_p.L250L	NM_018252.2	NP_060722.2	Q9H813	TM206_HUMAN	transmembrane protein 206	189						integral to membrane				breast(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	17				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		TACTCTTGTTCAGGCGGAACT	0.517000													19	77					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44216418	44216418	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:44216418C>T	ENST00000371554.1	+	2	266	c.52C>T	c.(52-54)Cag>Tag	p.Q18*	HSP90AB1_ENST00000371646.5_Nonsense_Mutation_p.Q18*|HSP90AB1_ENST00000353801.3_Nonsense_Mutation_p.Q18*			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	18					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding	p.Q18*(2)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTTTGCCTTTCAGGCAGAAAT	0.423000													30	89					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27237917	27237917	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:27237917G>A	ENST00000222753.4	-	2	1095	c.1067C>T	c.(1066-1068)tCa>tTa	p.S356L		NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	356					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						CGTCGTGGCTGATATCCGCCT	0.433000			T	NUP98	AML								5	245					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139941	50139941	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:50139941G>A	ENST00000371564.3	-	2	1058	c.839C>T	c.(838-840)tCa>tTa	p.S280L	NFATC2_ENST00000414705.1_Missense_Mutation_p.S260L|NFATC2_ENST00000396009.3_Missense_Mutation_p.S280L|NFATC2_ENST00000609507.1_Missense_Mutation_p.S61L|NFATC2_ENST00000610033.1_Missense_Mutation_p.S61L|NFATC2_ENST00000609943.1_Missense_Mutation_p.S260L	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	280	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CACGTGAGATGAGGGCTGCGG	0.716000													13	25					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120586011	120586011	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:120586011G>A	ENST00000300648.6	-	37	4698	c.4686C>T	c.(4684-4686)ctC>ctT	p.L1562L		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1562					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGATCTGCCTGAGCGCCTGCT	0.597000													12	25					0	0	1	0	0
SGPL1	8879	broad.mit.edu	37	10	72636307	72636307	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:72636307C>T	ENST00000373202.3	+	14	1655	c.1455C>T	c.(1453-1455)ttC>ttT	p.F485F		NM_003901.3	NP_003892.2	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	485					apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity			large_intestine(4)	4					Pyridoxal Phosphate(DB00114)	GTATTCATTTCTGCATCACAT	0.393000													20	20					0	0	1	0	0
GCAT	23464	broad.mit.edu	37	22	38211178	38211178	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:38211178G>A	ENST00000323205.6	+	5	763	c.700G>A	c.(700-702)Gat>Aat	p.D234N	GCAT_ENST00000248924.6_Missense_Mutation_p.D208N	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	208					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CTTTTCCATGGATGGCGACAT	0.597000													10	51					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61180839	61180839	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:61180839G>A	ENST00000216513.4	-	3	1691	c.1632C>T	c.(1630-1632)ttC>ttT	p.F544F		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	544						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GAGAGCTCAAGAAAACCTTTC	0.433000													17	37					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142215323	142215323	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:142215323C>G	ENST00000350721.4	-	34	5899	c.5778G>C	c.(5776-5778)caG>caC	p.Q1926H	ATR_ENST00000383101.3_Missense_Mutation_p.Q1862H	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1926	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity	p.Q1926H(1)		NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						CCCTGGCACTCTGCAGCCAGC	0.473000								Other conserved DNA damage response genes					36	43					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150443406	150443406	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:150443406C>T	ENST00000401000.4	+	10	1969	c.1904C>T	c.(1903-1905)tCa>tTa	p.S635L	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.S661L|RPRD2_ENST00000539519.1_Missense_Mutation_p.S635L			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	661	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AAGCTGGAGTCAGAGTCCACC	0.473000													37	70					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31612317	31612317	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31612317G>A	ENST00000404765.2	-	11	1721	c.1432C>T	c.(1432-1434)Cat>Tat	p.H478Y	BAG6_ENST00000375976.4_Missense_Mutation_p.H478Y|BAG6_ENST00000362049.6_Missense_Mutation_p.H478Y|BAG6_ENST00000211379.5_Missense_Mutation_p.H478Y|BAG6_ENST00000439687.2_Missense_Mutation_p.H478Y|BAG6_ENST00000375964.6_Missense_Mutation_p.H484Y			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	484	4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTTTGGCCATGACCAGGGGGT	0.622000													6	34					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39831062	39831062	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:39831062C>T	ENST00000309060.3	-	4	2910	c.2495G>A	c.(2494-2496)cGa>cAa	p.R832Q	ZHX3_ENST00000432768.2_Missense_Mutation_p.R832Q|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000560361.1_Missense_Mutation_p.R832Q|ZHX3_ENST00000540170.1_Missense_Mutation_p.R832Q|ZHX3_ENST00000544979.2_Missense_Mutation_p.R832Q|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000559234.1_Missense_Mutation_p.R832Q			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	832					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				GAAGTTGCCTCGCTTATAGTC	0.562000													50	129					0	0	1	0	0
ZNF561	93134	broad.mit.edu	37	19	9721764	9721764	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:9721764G>A	ENST00000302851.3	-	6	936	c.573C>T	c.(571-573)ctC>ctT	p.L191L	ZNF561_ENST00000495503.1_5'UTR|ZNF561_ENST00000326044.5_3'UTR|ZNF561_ENST00000424629.1_Silent_p.L122L|ZNF561_ENST00000354661.4_Silent_p.L55L	NM_152289.2	NP_689502.2	Q8N587	ZN561_HUMAN	zinc finger protein 561	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	14						GTCTTGCATTGAGAACTTCAA	0.393000													20	28					0	0	1	0	0
NUDT5	11164	broad.mit.edu	37	10	12226948	12226948	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:12226948G>A	ENST00000491614.1	-	3	466	c.71C>T	c.(70-72)tCa>tTa	p.S24L	NUDT5_ENST00000378940.3_Missense_Mutation_p.S24L|NUDT5_ENST00000537776.1_Missense_Mutation_p.S24L|NUDT5_ENST00000378937.3_Missense_Mutation_p.S24L|NUDT5_ENST00000378952.3_5'UTR|NUDT5_ENST00000378927.3_Missense_Mutation_p.S24L			Q9UKK9	NUDT5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 5	24					D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)	8		Renal(717;0.228)				TTTTCCTTCTGAAATTAACTA	0.313000													10	21					0	0	1	0	0
MRFAP1	93621	broad.mit.edu	37	4	6642607	6642607	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:6642607C>T	ENST00000320912.4	+	2	671	c.18C>T	c.(16-18)atC>atT	p.I6I	MRFAP1_ENST00000382581.4_Silent_p.I6I|MRFAP1_ENST00000507420.1_Silent_p.I6I	NM_001272053.1	NP_001258982.1	Q9Y605	MOFA1_HUMAN	Morf4 family associated protein 1	6						nucleus|perinuclear region of cytoplasm	protein binding			lung(1)	1						CCCTGGACATCGTCGAGCTGG	0.582000													40	145					0	0	1	0	0
SIAH1	6477	broad.mit.edu	37	16	48395835	48395835	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:48395835C>T	ENST00000380006.2	-	1	1958	c.505G>A	c.(505-507)Gac>Aac	p.D169N	SIAH1_ENST00000356721.3_Missense_Mutation_p.D200N|SIAH1_ENST00000394725.2_Missense_Mutation_p.D169N			Q8IUQ4	SIAH1_HUMAN	siah E3 ubiquitin protein ligase 1	169	SBD.				axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|stomach(1)	7		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				AGATTAATGTCTGTAGCAAGA	0.428000													9	50					0	0	1	0	0
RIN1	9610	broad.mit.edu	37	11	66100827	66100827	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:66100827C>T	ENST00000311320.4	-	9	1903	c.1777G>A	c.(1777-1779)Ggt>Agt	p.G593S	RIN1_ENST00000524804.1_5'UTR|RIN1_ENST00000424433.2_Missense_Mutation_p.G488S|RIN1_ENST00000530056.1_Missense_Mutation_p.G427S	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	593	Ras and 14-3-3 protein binding region.|VPS9.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						TGGGCCTGACCCAGGCCACTC	0.687000													20	42					0	0	1	0	0
JADE1	79960	broad.mit.edu	37	4	129764159	129764159	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:129764159C>G	ENST00000226319.6	+	3	384	c.104C>G	c.(103-105)tCc>tGc	p.S35C	PHF17_ENST00000512960.1_Missense_Mutation_p.S35C|PHF17_ENST00000511647.1_Missense_Mutation_p.S35C|PHF17_ENST00000413543.2_Missense_Mutation_p.S35C|PHF17_ENST00000452328.2_Missense_Mutation_p.S35C	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		35					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						AGGAGAAGCTCCTGCTCCAGA	0.448000													19	30					0	0	1	0	0
SERF2	10169	broad.mit.edu	37	15	44085187	44085187	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:44085187G>A	ENST00000381359.1	+	4	951	c.22G>A	c.(22-24)Gag>Aag	p.E8K	SERF2_ENST00000409646.1_Missense_Mutation_p.E8K|SERF2_ENST00000409614.1_5'UTR|RP11-296A16.1_ENST00000417761.2_Intron|SERF2_ENST00000403425.1_5'UTR|SERF2_ENST00000594896.1_5'UTR|SERF2_ENST00000409291.1_5'UTR|SERF2_ENST00000409960.2_Missense_Mutation_p.E8K|SERF2_ENST00000339624.5_Missense_Mutation_p.E8K|SERF2_ENST00000402131.1_5'UTR|SERF2_ENST00000249786.4_Missense_Mutation_p.E8K	NM_001199877.1	NP_001186806.1	P84101	SERF2_HUMAN	small EDRK-rich factor 2	8						cytosol|nucleus				lung(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		TAACCAGCGTGAGCTCGCCCG	0.612000													6	8					0	0	1	0	0
UPK3B	80761	broad.mit.edu	37	7	76143381	76143381	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:76143381C>T	ENST00000443097.2	+	5	884	c.659C>T	c.(658-660)tCt>tTt	p.S220F	UPK3B_ENST00000334348.3_Missense_Mutation_p.S220F|UPK3B_ENST00000419923.2_Silent_p.L248L|UPK3B_ENST00000394849.1_Silent_p.L193L|UPK3B_ENST00000448265.3_Silent_p.L248L|UPK3B_ENST00000257632.5_Silent_p.L248L			Q9BT76	UPK3B_HUMAN	uroplakin 3B	0					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				TTGGCAGCCTCTACCATGCGC	0.617000													25	106					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25074464	25074464	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:25074464C>G	ENST00000381989.3	-	4	496	c.391G>C	c.(391-393)Gaa>Caa	p.E131Q		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	131					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TCAGTGAGTTCCACAGTGTCT	0.398000													45	22					0	0	1	0	0
MRFAP1L1	114932	broad.mit.edu	37	4	6711006	6711006	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:6711006G>A	ENST00000320848.6	-	1	601	c.351C>T	c.(349-351)ctC>ctT	p.L117L		NM_203462.2	NP_982287.1	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	117																	TTCGCCAGACGAGCTCGACCA	0.547000													28	76					0	0	1	0	0
ZNF500	26048	broad.mit.edu	37	16	4815843	4815843	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:4815843G>A	ENST00000219478.6	-	2	436	c.137C>T	c.(136-138)cCt>cTt	p.P46L	ZNF500_ENST00000545009.1_Missense_Mutation_p.P46L			O60304	ZN500_HUMAN	zinc finger protein 500	46					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	21						GAAAGTCTCAGGGCTGGGGTC	0.642000													11	41					0	0	1	0	0
BCCIP	56647	broad.mit.edu	37	10	127512234	127512234	+	Silent	SNP	T	T	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:127512234T>C	ENST00000299130.3	+	1	120	c.108T>C	c.(106-108)gaT>gaC	p.D36D	BCCIP_ENST00000429863.2_Silent_p.D36D|BCCIP_ENST00000278100.6_Silent_p.D36D|BCCIP_ENST00000368759.5_Silent_p.D36D	NM_078469.2	NP_510869.1	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A interacting protein	36					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)	8		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				aaaatgaggatgaagacgatg	0.537000													33	24					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79273026	79273026	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:79273026C>T	ENST00000419573.3	-	25	3752	c.3478G>A	c.(3478-3480)Gat>Aat	p.D1160N	RASGRF1_ENST00000560334.1_5'UTR|RP11-16K12.1_ENST00000316148.4_RNA|RASGRF1_ENST00000394745.3_Missense_Mutation_p.D376N|RASGRF1_ENST00000558480.2_Missense_Mutation_p.D1144N	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1162	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGGAGCTTATCAATCAAAGCT	0.448000													14	21					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166952227	166952227	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:166952227C>G	ENST00000510118.1	-	4	560	c.220G>C	c.(220-222)Gag>Cag	p.E74Q	RPS6KA2_ENST00000405189.3_5'UTR|RPS6KA2_ENST00000481261.2_5'UTR|RPS6KA2_ENST00000366863.2_5'UTR|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.E49Q|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.E57Q			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	49	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TCAAAGCCCTCCTTCACATGA	0.537000													27	27					0	0	1	0	0
RPL31P11	641311	broad.mit.edu	37	1	161654839	161654839	+	RNA	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161654839C>T	ENST00000426558.1	-	0	203					NR_002595.1																						CCATCTCCTTCATGCCAAATT	0.507000													9	14					0	0	1	0	0
WARS	7453	broad.mit.edu	37	14	100820867	100820867	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:100820867C>G	ENST00000355338.2	-	5	1077	c.459G>C	c.(457-459)aaG>aaC	p.K153N	WARS_ENST00000344102.5_Missense_Mutation_p.K112N|WARS_ENST00000557135.1_Missense_Mutation_p.K153N|WARS_ENST00000392882.2_Missense_Mutation_p.K153N|WARS_ENST00000554084.1_5'UTR|WARS_ENST00000358655.4_Missense_Mutation_p.K112N|WARS_ENST00000556645.1_Missense_Mutation_p.K112N	NM_173701.1	NP_776049.1	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase	153					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	AAAATGGCTTCTTATTTTCAT	0.388000													29	46					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17548813	17548813	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:17548813G>A	ENST00000005226.7	-	5	452	c.453C>T	c.(451-453)atC>atT	p.I151I	USH1C_ENST00000527020.1_Silent_p.I151I|USH1C_ENST00000318024.4_Silent_p.I151I|USH1C_ENST00000527720.1_Silent_p.I120I	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	151	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GAATGAGGTTGATGACCTCCT	0.562000													30	55					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30704952	30704952	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:30704952C>T	ENST00000256246.2	-	1	1656	c.1582G>A	c.(1582-1584)Gaa>Aaa	p.E528K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	528										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTCAAAATTTCTATATTGTGG	0.318000													21	36					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80042141	80042141	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:80042141G>A	ENST00000306749.2	-	28	5106	c.4888C>T	c.(4888-4890)Ccg>Tcg	p.P1630S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1630					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	AGGAAGTCCGGTGACAGCAGG	0.657000													5	31					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39832404	39832404	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:39832404G>C	ENST00000309060.3	-	4	1568	c.1153C>G	c.(1153-1155)Cag>Gag	p.Q385E	ZHX3_ENST00000432768.2_Missense_Mutation_p.Q385E|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000560361.1_Missense_Mutation_p.Q385E|ZHX3_ENST00000540170.1_Missense_Mutation_p.Q385E|ZHX3_ENST00000544979.2_Missense_Mutation_p.Q385E|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000559234.1_Missense_Mutation_p.Q385E			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	385	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				ATTGTGGGCTGAGGCACAGAC	0.557000													52	74					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73679098	73679098	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:73679098C>T	ENST00000264448.6	+	8	5552	c.5441C>T	c.(5440-5442)tCc>tTc	p.S1814F	ALMS1_ENST00000377715.1_Missense_Mutation_p.S1814F|ALMS1_ENST00000409009.1_Missense_Mutation_p.S1772F	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1814	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CCCATTGTTTCCTACCAGCGA	0.463000													89	111					0	0	1	0	0
IFNA2	3440	broad.mit.edu	37	9	21384831	21384831	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:21384831G>A	ENST00000380206.2	-	1	565	c.498C>T	c.(496-498)gtC>gtT	p.V166V		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	166					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TTTCTGCTCTGACAACCTCCC	0.383000													90	220					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23549689	23549689	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:23549689G>A	ENST00000262710.1	-	6	1356	c.1029C>T	c.(1027-1029)tcC>tcT	p.S343S	ACIN1_ENST00000555053.1_Silent_p.S343S|ACIN1_ENST00000605057.1_Silent_p.S285S|ACIN1_ENST00000457657.1_Silent_p.S303S	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	343	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CCTCTTCCTGGGATCTTGTAA	0.443000													23	56					0	0	1	0	0
POLG	5428	broad.mit.edu	37	15	89865068	89865068	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:89865068C>T	ENST00000268124.5	-	16	2830	c.2497G>A	c.(2497-2499)Gag>Aag	p.E833K	POLG_ENST00000442287.2_Missense_Mutation_p.E833K	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	833					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AGGCCTTCCTCATCATAGTCG	0.622000								DNA polymerases (catalytic subunits)					20	52					0	0	1	0	0
VPS72	6944	broad.mit.edu	37	1	151158411	151158411	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:151158411C>T	ENST00000354473.4	-	2	169	c.133G>A	c.(133-135)Gag>Aag	p.E45K	VPS72_ENST00000496809.1_5'UTR			Q15906	VPS72_HUMAN	vacuolar protein sorting 72 homolog (S. cerevisiae)	45	Asp/Glu-rich (acidic).				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	14	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTTGATACTCATCATCTCCG	0.498000													15	60					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96104184	96104184	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:96104184C>G	ENST00000453304.1	-	14	2663	c.2315G>C	c.(2314-2316)gGa>gCa	p.G772A		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	772					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCTTTGAGATCCACTCCAAAC	0.433000													4	100					0	0	1	0	0
UNC93A	54346	broad.mit.edu	37	6	167728848	167728848	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:167728848G>C	ENST00000230256.3	+	8	1457	c.1282G>C	c.(1282-1284)Gtg>Ctg	p.V428L	UNC93A_ENST00000366829.2_Missense_Mutation_p.V386L	NM_018974.3	NP_061847.2	Q86WB7	UN93A_HUMAN	unc-93 homolog A (C. elegans)	428						integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	40		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GTATGGGCTTGTGGAGTGCGT	0.537000													113	163					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24776069	24776069	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:24776069G>C	ENST00000221166.5	+	3	3483	c.2701G>C	c.(2701-2703)Gaa>Caa	p.E901Q	NEFM_ENST00000433454.2_Missense_Mutation_p.E525Q|NEFM_ENST00000437366.2_Missense_Mutation_p.E862Q|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000518131.1_Missense_Mutation_p.E683Q			P07197	NFM_HUMAN	neurofilament, medium polypeptide	901	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TAAAAAGGTAGAAAAAGTCAC	0.388000													58	141					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90383903	90383903	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:90383903C>G	ENST00000369393.3	-	79	13282	c.13167G>C	c.(13165-13167)gaG>gaC	p.E4389D	RP1-122O8.7_ENST00000438877.1_RNA|MDN1_ENST00000428876.1_Missense_Mutation_p.E4389D			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	4389					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTTAGCATCTCTGTTAATC	0.443000													16	19					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221054599	221054599	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:221054599C>T	ENST00000366903.6	+	2	2157	c.656C>T	c.(655-657)tCg>tTg	p.S219L	HLX_ENST00000549319.1_5'UTR	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	219					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		CTGCAGCCCTCGGCCGGCCAG	0.562000													36	112					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62022936	62022936	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:62022936G>A	ENST00000435607.1	-	19	3580	c.3504C>T	c.(3502-3504)ctC>ctT	p.L1168L	SCN4A_ENST00000578147.1_Silent_p.L1168L	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1168					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCCAGAAGATGAGGCAGACAA	0.577000													144	174					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118483001	118483001	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:118483001C>G	ENST00000311085.8	+	17	2827	c.2747C>G	c.(2746-2748)tCt>tGt	p.S916C	DMXL1_ENST00000539542.1_Missense_Mutation_p.S916C	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	916										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAACATTATTCTTCTTCTCCA	0.398000													13	47					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48627617	48627617	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:48627617G>C	ENST00000006658.6	+	9	1162	c.1042G>C	c.(1042-1044)Gag>Cag	p.E348Q	SPATA20_ENST00000356488.4_Missense_Mutation_p.E332Q|SPATA20_ENST00000393244.3_Missense_Mutation_p.E288Q|SPATA20_ENST00000511937.1_3'UTR	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	332					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CCCTCACTTTGAGAAGATGCT	0.612000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	95					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62173800	62173800	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:62173800G>A	ENST00000217188.1	-	4	820	c.780C>T	c.(778-780)atC>atT	p.I260I		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	260	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			CACCTGACTTGATGACCTTGA	0.662000													9	30					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11097102	11097102	+	Missense_Mutation	SNP	G	G	A	rs74163613		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:11097102G>A	ENST00000409790.1	+	11	1473	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K	CLEC16A_ENST00000409552.3_Missense_Mutation_p.E413K	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	415										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AGAAGACGCCGAGAAGGCTAA	0.572000													8	41					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154183259	154183259	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:154183259C>T	ENST00000336314.4	+	13	2186	c.2162C>T	c.(2161-2163)tCa>tTa	p.S721L		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	798							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGCCAGACATCACGGTTTTAC	0.557000													24	58					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129901806	129901806	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:129901806C>T	ENST00000368654.3	-	13	8673	c.8298G>A	c.(8296-8298)ttG>ttA	p.L2766L	MKI67_ENST00000368653.3_Silent_p.L2406L	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2766	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAGATTCCTTCAATGCTTTGA	0.502000													48	45					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137485477	137485477	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:137485477G>A	ENST00000254900.5	-	23	3501	c.3130C>T	c.(3130-3132)Cag>Tag	p.Q1044*		NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1044					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GATTCTTGCTGAGCCTCCCCC	0.453000													5	84					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37687226	37687226	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:37687226C>T	ENST00000447079.4	+	14	4163	c.4130C>T	c.(4129-4131)tCa>tTa	p.S1377L	CDK12_ENST00000430627.2_Missense_Mutation_p.S1368L	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1377					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AGGACCTTCTCAGGCTCTCTG	0.562000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			18	43					0	0	1	0	0
C1QTNF4	114900	broad.mit.edu	37	11	47611502	47611502	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:47611502G>A	ENST00000302514.3	-	2	1377	c.861C>T	c.(859-861)ctC>ctT	p.L287L		NM_031909.2	NP_114115.2	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	287	C1q 2.					extracellular region				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						GGTCGTGGCTGAGCAGCCAGA	0.701000													7	17					0	0	1	0	0
MIR3654	100500804	broad.mit.edu	37	11	62358934	62358934	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:62358934G>A	ENST00000496634.2	-	1	69	c.24C>T	c.(22-24)gtC>gtT	p.V8V	TUT1_ENST00000476907.1_Silent_p.V8V|TUT1_ENST00000308436.7_Silent_p.V46V																NS(1)	1						GCAGCGATTCGACATCCGAAT	0.627000													24	37					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41877425	41877425	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:41877425G>A	ENST00000301831.4	-	18	2157	c.1695C>T	c.(1693-1695)ttC>ttT	p.F565F		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	565				AIVLLTELIRENFRNSKLKQCLLPTLGE -> TTSSIGIGI LNCLVQHSTPVPRQCLVYV (in Ref. 3; AAH14794).			ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TGCTGTTCCTGAAGTTTTCCC	0.358000													23	70					0	0	1	0	0
LOC101929735	101929735	broad.mit.edu	37	14	22929923	22929923	+	RNA	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:22929923G>A	ENST00000514473.2	-	0	225																											CGGGGAGAATGATGATGGTAG	0.423000													19	46					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48462263	48462263	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:48462263G>A	ENST00000358536.4	-	9	2182	c.1913C>T	c.(1912-1914)tCt>tTt	p.S638F	PLXNB1_ENST00000358459.4_Missense_Mutation_p.S638F|PLXNB1_ENST00000456774.1_Missense_Mutation_p.S638F|PLXNB1_ENST00000296440.6_Missense_Mutation_p.S638F|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	638					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCACTGCGCAGATGGGCGGAG	0.602000													18	34					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23293001	23293001	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:23293001C>T	ENST00000258733.4	+	2	441	c.146C>T	c.(145-147)tCt>tTt	p.S49F	GPNMB_ENST00000381990.2_Missense_Mutation_p.S49F|GPNMB_ENST00000453162.2_Missense_Mutation_p.S49F|GPNMB_ENST00000409458.3_Missense_Mutation_p.S49F|GPNMB_ENST00000539136.1_Intron			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	49					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			GGCTGGTCTTCTGATGAAAAT	0.413000													13	72					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735136	55735136	+	Missense_Mutation	SNP	G	G	C	rs144396433		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:55735136G>C	ENST00000312345.2	-	1	854	c.804C>G	c.(802-804)ttC>ttG	p.F268L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					GAATGGTGTAGAAAAGAGAAA	0.343000													12	24					0	0	1	0	0
LCMT2	9836	broad.mit.edu	37	15	43621411	43621411	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:43621411G>A	ENST00000305641.5	-	1	1392	c.1277C>T	c.(1276-1278)tCa>tTa	p.S426L	LCMT2_ENST00000567039.1_3'UTR|LCMT2_ENST00000544735.1_Missense_Mutation_p.S5L	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	426					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCGACTCTCTGAGAGTCTTGT	0.488000													52	40					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32626655	32626655	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:32626655C>G	ENST00000421745.2	+	8	1516	c.1382C>G	c.(1381-1383)tCt>tGt	p.S461C		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	461					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GAGGACTCCTCTAGTTGCTCA	0.388000													43	60					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54963353	54963353	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:54963353C>T	ENST00000243052.3	+	5	870	c.434C>T	c.(433-435)tCt>tTt	p.S145F	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000550620.1_Missense_Mutation_p.S125F|PDE1B_ENST00000538346.1_Missense_Mutation_p.S104F	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	145					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						ACATACACCTCTGTGGGCCCC	0.517000													12	24					0	0	1	0	0
BARD1	580	broad.mit.edu	37	2	215632218	215632218	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:215632218G>C	ENST00000260947.4	-	6	1690	c.1556C>G	c.(1555-1557)tCc>tGc	p.S519C	BARD1_ENST00000449967.2_Missense_Mutation_p.S375C	NM_000465.2|NM_001282543.1|NM_001282545.1|NM_001282548.1	NP_000456.2|NP_001269472.1|NP_001269474.1|NP_001269477.1	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	519					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGCATTTCTGGAGGCTCCATA	0.383000									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				20	15					0	0	1	0	0
EZH1	2145	broad.mit.edu	37	17	40876419	40876419	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:40876419C>G	ENST00000428826.2	-	5	391	c.270G>C	c.(268-270)ccG>ccC	p.P90P	EZH1_ENST00000435174.1_Intron|EZH1_ENST00000592743.1_Silent_p.P90P|EZH1_ENST00000590078.1_Silent_p.P20P|EZH1_ENST00000415827.2_Silent_p.P81P|EZH1_ENST00000585893.1_Intron			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	90					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		TTGCAAATCCCGGGAAAATGC	0.408000													15	37					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739619	55739619	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:55739619G>C	ENST00000370830.3	-	1	743	c.45C>G	c.(43-45)ctC>ctG	p.L15L	BMP5_ENST00000446683.2_Silent_p.L15L	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	15					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGCAGCTCCAGAGGAAACCCA	0.378000													46	166					0	0	1	0	0
KLK5	25818	broad.mit.edu	37	19	51452365	51452365	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:51452365G>A	ENST00000336334.3	-	4	694	c.342C>T	c.(340-342)ttC>ttT	p.F114F	KLK5_ENST00000391809.2_Silent_p.F114F|KLK5_ENST00000593428.1_Silent_p.F114F	NM_012427.4	NP_036559	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	114	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		GACGGACTCTGAAAACTCTGA	0.597000													86	84					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153277445	153277445	+	Silent	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:153277445G>T	ENST00000290722.1	-	3	406	c.354C>A	c.(352-354)atC>atA	p.I118I		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	118					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAAGAAGGCGATGCCCAGGG	0.537000													25	18					5.35356e-11	5.49596e-11	1	1	0
FAM63A	55793	broad.mit.edu	37	1	150974810	150974810	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:150974810G>A	ENST00000361936.5	-	3	1238	c.284C>T	c.(283-285)tCc>tTc	p.S95F	FAM63A_ENST00000312210.5_Intron|FAM63A_ENST00000470877.1_Intron|FAM63A_ENST00000493834.2_5'UTR|FAM63A_ENST00000361738.6_Missense_Mutation_p.S143F	NM_018379.4	NP_060849	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	95							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGGGGCATGGAGCATGCCCT	0.577000													28	37					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096826	73096826	+	Silent	SNP	C	C	T	rs138345813		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:73096826C>T	ENST00000450736.2	+	4	1483	c.1068C>T	c.(1066-1068)atC>atT	p.I356I	SLC16A5_ENST00000538213.2_Silent_p.I396I|SLC16A5_ENST00000329783.4_Silent_p.I356I|SLC16A5_ENST00000580123.1_Silent_p.I356I			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	356					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TCATGGACATCGTCCCCATGG	0.617000													26	42					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84806795	84806795	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:84806795C>T	ENST00000389394.3	+	14	2358	c.2221C>T	c.(2221-2223)Cag>Tag	p.Q741*	DNAH6_ENST00000398278.2_Nonsense_Mutation_p.Q741*|DNAH6_ENST00000237449.6_Nonsense_Mutation_p.Q741*	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	741	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						TGATGAAATTCAGGAACGGGT	0.358000													7	29					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974630	64974630	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:64974630G>A	ENST00000399262.2	-	8	1515	c.1297C>T	c.(1297-1299)Ccc>Tcc	p.P433S	JMJD1C_ENST00000399251.1_Missense_Mutation_p.P214S|JMJD1C_ENST00000402544.1_Missense_Mutation_p.P214S|JMJD1C_ENST00000542921.1_Missense_Mutation_p.P251S	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	433					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TGATCCCAGGGAGGCTGGCTA	0.363000													19	83					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73334757	73334757	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:73334757G>T	ENST00000377767.4	-	20	2803	c.2703C>A	c.(2701-2703)ttC>ttA	p.F901L	DIS3_ENST00000545453.1_Missense_Mutation_p.F739L|DIS3_ENST00000377780.4_Missense_Mutation_p.F871L	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	901					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CAAATACATGGAACACTGTAT	0.338000										Multiple Myeloma(4;0.011)			30	14					2.65835e-16	2.7548e-16	1	1	0
ZZEF1	23140	broad.mit.edu	37	17	4013096	4013096	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4013096G>A	ENST00000381638.2	-	6	1252	c.1128C>T	c.(1126-1128)ctC>ctT	p.L376L	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	376	DOC.						calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CAACAGCCCTGAGACCATGAA	0.443000													42	21					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178871301	178871301	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:178871301G>A	ENST00000367635.3	+	18	1923	c.1585G>A	c.(1585-1587)Gac>Aac	p.D529N	RALGPS2_ENST00000367634.2_Missense_Mutation_p.D503N	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	529	PH.|Required for stimulation of nucleotide exchange by RALA (By similarity).				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GATGGCTGATGACCCTGAACA	0.388000													24	42					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220752768	220752768	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:220752768C>T	ENST00000366918.4	+	2	721	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	MARK1_ENST00000366917.4_Missense_Mutation_p.R42W|MARK1_ENST00000402574.1_5'UTR|MARK1_ENST00000485104.1_3'UTR			Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	42					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		GAACATCCCCCGGTGTAGAAA	0.408000													16	36					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82124573	82124573	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:82124573C>T	ENST00000199936.4	+	4	924	c.731C>T	c.(730-732)tCa>tTa	p.S244L	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	244					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	ATGTTCTCATCAGTTATGAGA	0.473000													19	29					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640386	57640386	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:57640386G>A	ENST00000254181.4	+	4	797	c.343G>A	c.(343-345)Gat>Aat	p.D115N	USP29_ENST00000598197.1_Missense_Mutation_p.D115N	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	115					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAATCTGATGATGATTGGAG	0.353000													27	40					0	0	1	0	0
MRPL41	64975	broad.mit.edu	37	9	140446845	140446845	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:140446845C>T	ENST00000371443.5	+	2	1100	c.312C>T	c.(310-312)ttC>ttT	p.F104F		NM_032477.2	NP_115866.1	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	104					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		AAAAGGACTTCAAGGACGGTA	0.617000													11	31					0	0	1	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42410943	42410943	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:42410943C>T	ENST00000378152.4	+	26	2624	c.2526C>T	c.(2524-2526)ttC>ttT	p.F842F	ARHGEF1_ENST00000347545.4_3'UTR|ARHGEF1_ENST00000599846.1_3'UTR|ARHGEF1_ENST00000354532.3_3'UTR|ARHGEF1_ENST00000337665.4_3'UTR			Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor (GEF) 1	0					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACTTGAGGTTCCCGCCCAGGA	0.652000													12	27					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66444594	66444594	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:66444594G>A	ENST00000383703.3	-	13	2013	c.1410C>T	c.(1408-1410)tgC>tgT	p.C470C	LRIG1_ENST00000273261.3_Silent_p.C446C|LRIG1_ENST00000496559.2_5'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	446	LRRCT.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		ACTTCAGCTGGCAGTCACACA	0.557000													10	19					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110146628	110146628	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:110146628G>C	ENST00000351050.3	-	7	1005	c.819C>G	c.(817-819)ctC>ctG	p.L273L		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	273					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		TTTCCTCAAAGAGGTCCTTCT	0.388000													29	25					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60613531	60613531	+	Splice_Site	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:60613531C>A	ENST00000326270.9	+	7	632	c.364C>A	c.(364-366)Cga>Aga	p.R122R	TLK2_ENST00000542523.1_Splice_Site_p.R90R|TLK2_ENST00000343388.7_Splice_Site_p.R90R|TLK2_ENST00000582809.1_5'UTR|TLK2_ENST00000346027.5_Splice_Site_p.R122R	NM_001284333.1	NP_001271262.1	Q86UE8	TLK2_HUMAN	tousled-like kinase 2	122					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						TGTTTTCCAGCGACGAGTAGA	0.443000													16	34					4.7546e-09	4.85663e-09	1	1	0
HOXB7	3217	broad.mit.edu	37	17	46688210	46688210	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:46688210C>T	ENST00000239165.7	-	1	169	c.71G>A	c.(70-72)gGa>gAa	p.G24E	HOXB7_ENST00000567101.2_Intron	NM_004502.3	NP_004493.3	P09629	HXB7_HUMAN	homeobox B7	24						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	8						TGGGAAGGCTCCGGTAGCGAA	0.522000													33	65					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049837	49049837	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:49049837C>T	ENST00000395474.3	+	2	1240	c.960C>T	c.(958-960)ctC>ctT	p.L320L	WDR6_ENST00000415265.2_Intron|WDR6_ENST00000489684.1_3'UTR|WDR6_ENST00000448293.1_Silent_p.L239L|WDR6_ENST00000608424.1_Silent_p.L290L	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	290					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		GTGAGATCCTCCAGGCCTTTC	0.587000													38	75					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85778620	85778620	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:85778620C>G	ENST00000233838.4	-	12	1803	c.1723G>C	c.(1723-1725)Gag>Cag	p.E575Q	GGCX_ENST00000430215.3_Missense_Mutation_p.E518Q	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase						blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TTTTCTCCCTCTCGAAGAGTC	0.493000													25	119					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79430064	79430064	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:79430064C>T	ENST00000264895.6	+	63	10124	c.9684C>T	c.(9682-9684)ttC>ttT	p.F3228F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3223					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTGTGCAGTTCAGCTGGGAAG	0.572000													18	28					0	0	1	0	0
THAP6	152815	broad.mit.edu	37	4	76440731	76440731	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:76440731G>A	ENST00000311638.3	+	2	137	c.69G>A	c.(67-69)ctG>ctA	p.L23L	THAP6_ENST00000504190.1_Intron|THAP6_ENST00000507556.1_Silent_p.L23L|THAP6_ENST00000502620.1_Intron|THAP6_ENST00000380837.3_Silent_p.L23L|THAP6_ENST00000507885.1_Intron|THAP6_ENST00000508105.1_Intron|THAP6_ENST00000507557.1_Intron|THAP6_ENST00000514480.1_Silent_p.L23L	NM_144721.4	NP_653322.1	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	23						microtubule cytoskeleton	DNA binding|metal ion binding			lung(5)	5			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TAAAAGGACTGACATTTCACG	0.358000													30	49					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42717184	42717184	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:42717184G>A	ENST00000263805.4	-	13	5295	c.4969C>T	c.(4969-4971)Cgg>Tgg	p.R1657W	ZNF106_ENST00000565380.1_Missense_Mutation_p.R885W|ZNF106_ENST00000565611.1_Missense_Mutation_p.R842W	NM_001284306.1|NM_001284307.1|NM_022473.1	NP_001271235.1|NP_001271236.1|NP_071918.1			zinc finger protein 106																		CTGACTGCCCGAGGGCCATGG	0.478000													26	16					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9069001	9069001	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:9069001G>A	ENST00000457346.2	-	16	1978	c.1904C>T	c.(1903-1905)tCa>tTa	p.S635L	SCUBE2_ENST00000309263.3_Missense_Mutation_p.S606L|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000450649.2_Missense_Mutation_p.S480L|SCUBE2_ENST00000520467.1_Missense_Mutation_p.S635L			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	606						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GTTCATGCCTGAGAGCTGGAG	0.572000													21	33					0	0	1	0	0
AMMECR1	9949	broad.mit.edu	37	X	109561233	109561233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:109561233C>T	ENST00000262844.5	-	1	234	c.67G>A	c.(67-69)Ggc>Agc	p.G23S	AMMECR1_ENST00000372059.2_Missense_Mutation_p.G23S|AMMECR1_ENST00000372057.1_Intron	NM_015365.2	NP_056180.1	Q9Y4X0	AMER1_HUMAN	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	23	Gly/Ser-rich.									large_intestine(1)|lung(4)|ovary(1)|stomach(1)	7						CCACCACCGCCACCCGAGCCA	0.682000													8	4					0	0	1	0	0
IRF7	3665	broad.mit.edu	37	11	615238	615238	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:615238G>A	ENST00000397566.1	-	1	490	c.81C>T	c.(79-81)ttC>ttT	p.F27F	IRF7_ENST00000330243.5_Silent_p.F27F|IRF7_ENST00000525445.1_5'UTR|IRF7_ENST00000397562.3_5'UTR|IRF7_ENST00000348655.6_Silent_p.F14F|IRF7_ENST00000397570.1_Silent_p.F14F|IRF7_ENST00000397574.2_Silent_p.F14F	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	14					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCACTCTCCGAACAGCACGC	0.711000													3	15					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10525231	10525231	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:10525231G>C	ENST00000396560.2	+	3	981	c.754G>C	c.(754-756)Gat>Cat	p.D252H	ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000396559.1_Missense_Mutation_p.D252H|ATF7IP2_ENST00000356427.2_Missense_Mutation_p.D252H|ATF7IP2_ENST00000324570.5_Missense_Mutation_p.D252H	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TTTGAAAACTGATGAGTGTAG	0.358000													14	51					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74645875	74645875	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:74645875C>T	ENST00000287936.4	+	7	721	c.565C>T	c.(565-567)Cag>Tag	p.Q189*	HMGCR_ENST00000511206.1_Nonsense_Mutation_p.Q189*|HMGCR_ENST00000343975.5_Nonsense_Mutation_p.Q189*	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	189					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	AGGGGTACGTCAGCTTGAAAT	0.393000													23	45					0	0	1	0	0
TSEN34	79042	broad.mit.edu	37	19	54695644	54695644	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:54695644G>A	ENST00000396383.1	+	3	627	c.316G>A	c.(316-318)Gag>Aag	p.E106K	TSEN34_ENST00000396388.2_Missense_Mutation_p.E106K|TSEN34_ENST00000302937.4_Missense_Mutation_p.E106K|TSEN34_ENST00000429671.2_Missense_Mutation_p.E106K			Q9BSV6	SEN34_HUMAN	TSEN34 tRNA splicing endonuclease subunit	106					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	10	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGAGGCCCGGGAGACCCGTCG	0.612000													5	123					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32917584	32917584	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:32917584G>A	ENST00000374843.4	-	3	541	c.456C>T	c.(454-456)ctC>ctT	p.L152L	HLA-DMA_ENST00000395305.3_Silent_p.L57L|HLA-DMA_ENST00000464392.1_5'UTR|XXbac-BPG181M17.5_ENST00000429234.1_Intron|HLA-DMA_ENST00000395303.3_Intron	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	152						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						TGGGTGGGAAGAGATTACTGA	0.527000													15	47					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95480168	95480168	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:95480168G>A	ENST00000356884.6	-	6	2236	c.2169C>T	c.(2167-2169)acC>acT	p.T723T	BICD2_ENST00000375512.3_Silent_p.T723T	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	723	Interacts with RAB6A (By similarity).				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						TCATGGTCTCGGTAACCATGG	0.567000													37	94					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85778707	85778707	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:85778707C>T	ENST00000233838.4	-	12	1716	c.1636G>A	c.(1636-1638)Gaa>Aaa	p.E546K	GGCX_ENST00000430215.3_Missense_Mutation_p.E489K	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase						blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CCCAGGTCTTCACTCACAAAA	0.517000											OREG0014747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	116					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31289499	31289499	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:31289499G>A	ENST00000332585.6	+	10	2144	c.2040G>A	c.(2038-2040)agG>agA	p.R680R	OSBP2_ENST00000407373.1_Silent_p.R507R|OSBP2_ENST00000403222.3_Silent_p.R514R|OSBP2_ENST00000437268.2_Silent_p.R422R|OSBP2_ENST00000496575.1_3'UTR|OSBP2_ENST00000401475.1_Silent_p.R313R|OSBP2_ENST00000446658.2_Silent_p.R679R|OSBP2_ENST00000382310.3_Silent_p.R631R|OSBP2_ENST00000535268.1_Silent_p.R224R	NM_001282739.1|NM_001282740.1|NM_001282741.1|NM_001282742.1|NM_030758.3	NP_001269668.1|NP_001269669.1|NP_001269670.1|NP_001269671.1|NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	680					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						ACGTGTGGAGGAAGAGCACCT	0.632000													27	55					0	0	1	0	0
DNAJA4	55466	broad.mit.edu	37	15	78566603	78566603	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:78566603C>T	ENST00000394855.3	+	5	798	c.570C>T	c.(568-570)atC>atT	p.I190I	DNAJA4_ENST00000343789.3_Silent_p.I161I|DNAJA4_ENST00000394852.3_Silent_p.I161I|DNAJA4_ENST00000446172.2_Silent_p.I134I	NM_018602.3	NP_061072.3	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	161					protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	8						GGATGCAGATCCACATCCAGC	0.642000													19	37					0	0	1	0	0
TRGC1	6966	broad.mit.edu	37	7	38305039	38305039	+	RNA	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:38305039G>A	ENST00000443402.2	-	0	240					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					TTTGTCCAGTGACTTTTCTGG	0.398000													52	105					0	0	1	0	0
VENTX	27287	broad.mit.edu	37	10	135053664	135053664	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:135053664G>C	ENST00000325980.9	+	3	1142	c.631G>C	c.(631-633)Gag>Cag	p.E211Q		NM_014468.3	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	211					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		AGTGGCACAAGAGGCCCTGGC	0.706000													11	8					0	0	1	0	0
TRIM40	135644	broad.mit.edu	37	6	30114921	30114921	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:30114921C>A	ENST00000396581.1	+	4	987	c.601C>A	c.(601-603)Cag>Aag	p.Q201K	TRIM40_ENST00000376724.2_Missense_Mutation_p.Q201K|TRIM40_ENST00000307859.4_Missense_Mutation_p.Q172K			Q6P9F5	TRI40_HUMAN	tripartite motif containing 40	201						intracellular	zinc ion binding			ovary(1)	1						GGCAGTAACACAGCTCAGAAG	0.582000													37	73					2.05212e-20	2.13588e-20	1	1	0
ELMO3	79767	broad.mit.edu	37	16	67233098	67233098	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:67233098G>A	ENST00000393997.2	+	1	85	c.28G>A	c.(28-30)Gag>Aag	p.E10K	ELMO3_ENST00000360833.1_Missense_Mutation_p.E10K	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	0					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TCTGGGCCGCGAGTGCGGGAC	0.687000													5	20					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49438623	49438623	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:49438623C>T	ENST00000301067.7	-	19	4866	c.4867G>A	c.(4867-4869)Gag>Aag	p.E1623K		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AATCCTGCCTCGCCTGGGAGG	0.602000													29	67					0	0	1	0	0
SEPSECS	51091	broad.mit.edu	37	4	25146637	25146637	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:25146637T>C	ENST00000382103.2	-	7	995	c.923A>G	c.(922-924)aAg>aGg	p.K308R	SEPSECS_ENST00000302922.3_Missense_Mutation_p.K229R	NM_016955.3	NP_058651.3	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	308					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding			endometrium(1)|large_intestine(4)|lung(2)|stomach(1)	8		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	TGGATACATCTTGCTGATTTC	0.318000													8	43					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53989916	53989916	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:53989916G>A	ENST00000396403.4	+	3	174	c.46G>A	c.(46-48)Gaa>Aaa	p.E16K	ZNF813_ENST00000396421.4_Missense_Mutation_p.E16K	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	16	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TGTGGCCATAGAATTCTCTCA	0.448000													49	183					0	0	1	0	0
TRAV34	28648	broad.mit.edu	37	14	22675791	22675791	+	RNA	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:22675791G>C	ENST00000390461.2	+	0	115																											GATCGTCCAAGAGGGAAAGAA	0.398000													8	12					0	0	1	0	0
USP36	57602	broad.mit.edu	37	17	76810611	76810611	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:76810611G>A	ENST00000542802.3	-	11	1490	c.1047C>T	c.(1045-1047)ctC>ctT	p.L349L	USP36_ENST00000312010.6_Silent_p.L349L|USP36_ENST00000449938.2_Silent_p.L49L|USP36_ENST00000588467.1_5'UTR			Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36						ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			GACGTATGTTGAGGAATTCCG	0.443000													15	37					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50943035	50943035	+	Missense_Mutation	SNP	G	G	C	rs147119038	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:50943035G>C	ENST00000216080.5	-	11	1652	c.1484C>G	c.(1483-1485)cCg>cGg	p.P495R	LMF2_ENST00000474879.2_Missense_Mutation_p.P520R|LMF2_ENST00000380796.3_Missense_Mutation_p.P407R			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	520						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGTGAACCACGGGCTGTGCGT	0.711000													9	23					0	0	1	0	0
H1FX	8971	broad.mit.edu	37	3	129034285	129034285	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:129034285G>A	ENST00000333762.4	-	1	835	c.461C>T	c.(460-462)tCc>tTc	p.S154F	H1FX-AS1_ENST00000511998.1_RNA	NM_006026.3	NP_006017.1	Q92522	H1X_HUMAN	H1 histone family, member X	154					nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)|ovary(1)|urinary_tract(2)	4						cgcgcgccgggagccggccgc	0.771000													7	16					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53608274	53608274	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:53608274G>A	ENST00000425354.2	-	6	1079	c.592C>T	c.(592-594)Cag>Tag	p.Q198*	RARG_ENST00000338561.5_Nonsense_Mutation_p.Q187*|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000543726.1_Nonsense_Mutation_p.Q176*|RARG_ENST00000327550.3_Nonsense_Mutation_p.Q126*|RARG_ENST00000394426.1_Nonsense_Mutation_p.Q198*	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	198	Hinge.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AAAGTCTCCTGATGGGCTTTG	0.547000													27	54					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47809094	47809094	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:47809094C>T	ENST00000285106.6	-	15	2554	c.1840G>A	c.(1840-1842)Gag>Aag	p.E614K	CXXC1_ENST00000412036.2_Missense_Mutation_p.E618K|CXXC1_ENST00000589940.1_Silent_p.T601T	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	614					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TCAAACAGCTCGTCCAGCTTG	0.627000													27	53					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40756423	40756423	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:40756423G>A	ENST00000216194.7	+	7	775	c.719G>A	c.(718-720)gGg>gAg	p.G240E	ADSL_ENST00000342312.6_Missense_Mutation_p.G240E|ADSL_ENST00000480775.1_3'UTR|ADSL_ENST00000454266.2_Missense_Mutation_p.G254E	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	240					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						ATCATCACAGGGCAGACATAT	0.463000													23	45					0	0	1	0	0
FOXL1	2300	broad.mit.edu	37	16	86612809	86612809	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:86612809G>A	ENST00000320241.3	+	1	695	c.480G>A	c.(478-480)gaG>gaA	p.E160E		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	160					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						CCCGCGCCGAGACGCACCAGC	0.776000													4	9					0	0	1	0	0
OCRL	4952	broad.mit.edu	37	X	128696762	128696762	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:128696762G>A	ENST00000371113.4	+	12	1408	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K	OCRL_ENST00000357121.5_Splice_Site_p.E415K	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	415					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						CATGAAACATGAGTAAGTGGT	0.418000													52	27					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101852653	101852653	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:101852653G>A	ENST00000263468.8	+	8	3262	c.2992G>A	c.(2992-2994)Gag>Aag	p.E998K	KIAA1377_ENST00000537689.1_Missense_Mutation_p.E799K	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	998							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AAGTTCAAGTGAGCCAAAACA	0.279000													7	13					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80164057	80164057	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:80164057C>G	ENST00000281127.7	+	4	1565	c.686C>G	c.(685-687)tCt>tGt	p.S229C	NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000428277.2_Missense_Mutation_p.S259C|NRXN3_ENST00000554719.1_Missense_Mutation_p.S861C|RP11-242P2.1_ENST00000553322.1_RNA|NRXN3_ENST00000557594.1_Missense_Mutation_p.S229C|NRXN3_ENST00000335750.5_Missense_Mutation_p.S861C	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	229	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGCCAACTCTCTGGGCTCTAT	0.493000													25	39					0	0	1	0	0
RIN1	9610	broad.mit.edu	37	11	66102614	66102614	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:66102614C>A	ENST00000311320.4	-	6	782	c.656G>T	c.(655-657)gGa>gTa	p.G219V	RP11-867G23.12_ENST00000526655.1_RNA|RIN1_ENST00000424433.2_Missense_Mutation_p.G114V|RIN1_ENST00000530056.1_Missense_Mutation_p.G114V	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	219					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						CAAGGCGGCTCCGGTGCCCTG	0.642000													47	59					8.72198e-27	9.09123e-27	1	1	0
GPR107	57720	broad.mit.edu	37	9	132854562	132854562	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:132854562C>G	ENST00000372406.1	+	9	1272	c.765C>G	c.(763-765)ctC>ctG	p.L255L	GPR107_ENST00000347136.6_Silent_p.L255L|GPR107_ENST00000372410.3_Silent_p.L255L	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	255						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				ACAGCTACCTCTCAGCAGGAG	0.388000													9	36					0	0	1	0	0
ARF6	382	broad.mit.edu	37	14	50360532	50360532	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:50360532G>C	ENST00000298316.5	+	2	625	c.78G>C	c.(76-78)aaG>aaC	p.K26N		NM_001663.3	NP_001654.1	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	26					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding			endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)	4	all_epithelial(31;0.000822)|Breast(41;0.0117)					CGGCCGGCAAGACAACAATCC	0.557000													21	83					0	0	1	0	0
RPL23A	6147	broad.mit.edu	37	17	27047883	27047883	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:27047883C>T	ENST00000422514.2	+	2	797	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W	RPL23A_ENST00000472628.1_5'UTR|RPL23A_ENST00000496182.1_5'UTR|RPL23A_ENST00000394938.4_Missense_Mutation_p.R100W	NM_000984.5	NP_000975.2	P62750	RL23A_HUMAN	ribosomal protein L23a	62					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			endometrium(1)|lung(3)|ovary(1)	5	Lung NSC(42;0.00431)					CAAATATCCTCGGAAGAGCGC	0.517000											OREG0024282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	70					0	0	1	0	0
EPS8	2059	broad.mit.edu	37	12	15803792	15803792	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:15803792G>A	ENST00000281172.5	-	14	1835	c.1399C>T	c.(1399-1401)Cag>Tag	p.Q467*	EPS8_ENST00000543523.1_Nonsense_Mutation_p.Q467*|EPS8_ENST00000540613.1_Nonsense_Mutation_p.Q207*|EPS8_ENST00000542903.1_Nonsense_Mutation_p.Q207*|EPS8_ENST00000543612.1_Nonsense_Mutation_p.Q467*	NM_004447.5	NP_004438.3	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway substrate 8	467					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TGTTTGCGCTGATGTTCTGCT	0.408000													33	65					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19835150	19835150	+	Missense_Mutation	SNP	G	G	A	rs146622968		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:19835150G>A	ENST00000225737.6	-	10	1766	c.1609C>T	c.(1609-1611)Cac>Tac	p.H537Y	AKAP10_ENST00000395536.3_Intron	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	537					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CTCCCTGGGTGAGACTCATCA	0.502000													23	112					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21097558	21097558	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:21097558G>C	ENST00000377122.4	-	26	3038	c.2642C>G	c.(2641-2643)tCt>tGt	p.S881C	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	881	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATGGGATCGAGACCAGTGTCG	0.423000													29	92					0	0	1	0	0
LSM4	25804	broad.mit.edu	37	19	18420561	18420561	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:18420561G>A	ENST00000593829.1	-	4	508	c.255C>T	c.(253-255)gcC>gcT	p.A85A	LSM4_ENST00000252816.6_Silent_p.A71A	NM_001252129.1|NM_012321.4	NP_001239058.1|NP_036453.1	Q9Y4Z0	LSM4_HUMAN	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	85					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing	cytosol|U6 snRNP	protein binding|RNA binding			endometrium(1)|large_intestine(2)|lung(3)	6						CGCGGCCCTTGGCCACCACCT	0.667000													16	42					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137465	40137465	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:40137465G>A	ENST00000278198.2	-	2	2341	c.378C>T	c.(376-378)ctC>ctT	p.L126L	LRRC4C_ENST00000530763.1_Silent_p.L126L|LRRC4C_ENST00000527150.1_Silent_p.L126L|LRRC4C_ENST00000528697.1_Silent_p.L126L			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	126					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				CCAGAGTGTTGAGGTTCGCCA	0.443000													17	28					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19861501	19861501	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:19861501G>A	ENST00000225737.6	-	4	860	c.703C>T	c.(703-705)Cac>Tac	p.H235Y	AKAP10_ENST00000395536.3_Missense_Mutation_p.H235Y	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	235	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					AGCAGCAAGTGATTCTGAGTG	0.438000													28	109					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058492	152058492	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:152058492C>G	ENST00000368806.1	-	3	1730	c.1666G>C	c.(1666-1668)Gag>Cag	p.E556Q		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	556							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTGCCTTCCTCTGAAGCCAGG	0.552000													35	115					0	0	1	0	0
GPR101	83550	broad.mit.edu	37	X	136113078	136113078	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:136113078C>T	ENST00000298110.1	-	1	755	c.756G>A	c.(754-756)aaG>aaA	p.K252K		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	252						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					ACTCCTCCTTCTTCTCTGCTC	0.557000													91	40					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122729133	122729133	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:122729133G>A	ENST00000306467.5	-	6	975	c.671C>T	c.(670-672)tCt>tTt	p.S224F	CEP120_ENST00000306481.6_Missense_Mutation_p.S198F|CEP120_ENST00000328236.5_Missense_Mutation_p.S224F|CEP120_ENST00000395431.2_Missense_Mutation_p.S224F			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	224						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TCCCAGTAAAGAGTAGTAAAA	0.353000													29	47					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63948526	63948526	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:63948526C>G	ENST00000443617.2	-	49	9718	c.9631G>C	c.(9631-9633)Gag>Cag	p.E3211Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3211					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCCAGAGACTCAAGACCAGCA	0.502000													10	48					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94109981	94109981	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:94109981C>T	ENST00000553484.1	+	36	6319	c.6165C>T	c.(6163-6165)ttC>ttT	p.F2055F	UNC79_ENST00000555664.1_Silent_p.F1994F|UNC79_ENST00000393151.2_Silent_p.F2033F|UNC79_ENST00000256339.4_Silent_p.F1856F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2033						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TCTCCACATTCATTCACTTAA	0.502000													27	73					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971199	21971199	+	Missense_Mutation	SNP	C	C	A	rs104894095		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:21971199C>A	ENST00000579755.1	-	2	494	c.202G>T	c.(202-204)Gat>Tat	p.D68Y	RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000530628.2_Missense_Mutation_p.D68Y|CDKN2A_ENST00000578845.2_Missense_Mutation_p.M2I|CDKN2A_ENST00000446177.1_Missense_Mutation_p.M53I|CDKN2A_ENST00000498628.2_Missense_Mutation_p.M2I|CDKN2A_ENST00000479692.2_Missense_Mutation_p.M2I|CDKN2A_ENST00000497750.1_Missense_Mutation_p.M2I|CDKN2A_ENST00000579122.1_Missense_Mutation_p.M53I|CDKN2A_ENST00000494262.1_Missense_Mutation_p.M2I|CDKN2A_ENST00000498124.1_Missense_Mutation_p.M53I|CDKN2A_ENST00000361570.3_Missense_Mutation_p.D109Y|CDKN2A_ENST00000304494.5_Missense_Mutation_p.M53I			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	44			A -> L (in CMM2; requires 2 nucleotide substitutions).|A -> T (in an esophagus tumor).|A -> V.|Missing (in melanoma; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(45)|p.M53_R58del(3)|p.M53I(2)|p.0(1)|p.V28_V51del(1)|p.D109H(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGCTGCCCATCATCATGACCT	0.677000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			12	21					9.31168e-06	9.43055e-06	1	1	0
C1QL1	10882	broad.mit.edu	37	17	43044835	43044835	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:43044835G>C	ENST00000253407.3	-	1	604	c.582C>G	c.(580-582)ctC>ctG	p.L194L		NM_006688.3	NP_006679.1	O75973	C1QRF_HUMAN	complement component 1, q subcomponent-like 1	194	C1q.				locomotory behavior	collagen				lung(1)|prostate(1)	2		Prostate(33;0.155)				CATTCTTGCAGAGGTCTGCCC	0.657000													8	18					0	0	1	0	0
H3F3B	3021	broad.mit.edu	37	17	73775020	73775020	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:73775020C>T	ENST00000254810.4	-	3	285	c.153G>A	c.(151-153)gaG>gaA	p.E51E	H3F3B_ENST00000591890.1_Silent_p.E51E|H3F3B_ENST00000589599.1_Silent_p.E51E|H3F3B_ENST00000593254.1_Intron|H3F3B_ENST00000587560.1_Silent_p.E51E|H3F3B_ENST00000592643.1_Silent_p.E51E|H3F3B_ENST00000586607.1_Silent_p.E51E	NM_005324.3	NP_005315.1	P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	51					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			AACGACGAATCTCTCGAAGCG	0.647000											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	61					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23885290	23885290	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:23885290C>G	ENST00000355349.3	-	34	5038	c.4876G>C	c.(4876-4878)Gag>Cag	p.E1626Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1626					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGCTGGATCTCCATCTCATTG	0.612000													6	113					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100890904	100890904	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:100890904C>T	ENST00000343933.5	-	9	1322	c.1065G>A	c.(1063-1065)atG>atA	p.M355I	CORO2A_ENST00000375077.4_Missense_Mutation_p.M355I	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	355					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				GGGGCACAATCATGGAGATGG	0.602000													30	41					0	0	1	0	0
GGCT	79017	broad.mit.edu	37	7	30536735	30536735	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:30536735G>A	ENST00000275428.4	-	4	674	c.540C>T	c.(538-540)atC>atT	p.I180I	GGCT_ENST00000409144.1_Silent_p.I86I|GGCT_ENST00000005374.6_3'UTR|GGCT_ENST00000409390.1_3'UTR|GGCT_ENST00000598361.1_Silent_p.I95I	NM_024051.3	NP_076956.1	O75223	GGCT_HUMAN	gamma-glutamylcyclotransferase	180					release of cytochrome c from mitochondria	cytosol	acyltransferase activity|gamma-glutamylcyclotransferase activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	8						CCCCCTTTTTGATGATGTCTT	0.333000													9	54					0	0	1	0	0
SSBP2	23635	broad.mit.edu	37	5	80932422	80932422	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:80932422T>A	ENST00000320672.4	-	3	361	c.151A>T	c.(151-153)Aac>Tac	p.N51Y	SSBP2_ENST00000514493.1_Missense_Mutation_p.N51Y|SSBP2_ENST00000515395.1_Missense_Mutation_p.N51Y|SSBP2_ENST00000509053.1_Missense_Mutation_p.N51Y|SSBP2_ENST00000505980.1_Missense_Mutation_p.N51Y	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	51					regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		AATGTGATGTTTTTTTCCCAT	0.313000													19	47					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127014673	127014673	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:127014673G>A	ENST00000393313.1	-	5	1308	c.717C>T	c.(715-717)ttC>ttT	p.F239F	ZNF800_ENST00000265827.3_Silent_p.F239F|ZNF800_ENST00000393312.1_Silent_p.F239F			Q2TB10	ZN800_HUMAN	zinc finger protein 800	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						GTCTAGAATTGAATTCTTTTC	0.383000													13	82					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169366570	169366570	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:169366570C>T	ENST00000545005.1	-	6	1779	c.1272G>A	c.(1270-1272)gaG>gaA	p.E424E	CCDC181_ENST00000367805.3_Silent_p.E424E|CCDC181_ENST00000367806.3_Silent_p.E425E					coiled-coil domain containing 181																		CTTTCATCTGCTCTTCGTGCT	0.368000													6	24					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651408	84651408	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:84651408G>A	ENST00000286744.5	+	21	3252	c.3028G>A	c.(3028-3030)Gag>Aag	p.E1010K	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.E1010K	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1010						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCCCTCAGGGAGCCTATGAG	0.522000													23	66					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780286	37780286	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:37780286C>G	ENST00000447769.1	+	4	580	c.291C>G	c.(289-291)atC>atG	p.I97M	EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.I97M|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	97						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TGCTGCACATCCACATGTACC	0.453000													11	67					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29819018	29819018	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:29819018G>A	ENST00000219782.6	+	2	1018	c.912G>A	c.(910-912)gaG>gaA	p.E304E	AC009133.15_ENST00000566537.1_RNA|MAZ_ENST00000545521.1_Silent_p.E281E|MAZ_ENST00000563402.1_Intron|MAZ_ENST00000322945.6_Silent_p.E304E|MAZ_ENST00000562337.1_Intron|MAZ_ENST00000566906.2_Intron	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	304					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						ACTCGGACGAGAAGCCCTACC	0.627000													22	87					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72308333	72308333	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:72308333G>A	ENST00000579490.1	+	11	1992	c.1857G>A	c.(1855-1857)aaG>aaA	p.K619K	DNAI2_ENST00000307504.5_Intron|DNAI2_ENST00000446837.2_Silent_p.K562K|DNAI2_ENST00000311014.6_Silent_p.K562K|DNAI2_ENST00000582036.1_Silent_p.K550K			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	562					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AGCTGAAGAAGAAGGAGGCAG	0.607000									Kartagener syndrome				13	20					0	0	1	0	0
ANKRD55	79722	broad.mit.edu	37	5	55396045	55396045	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:55396045C>T	ENST00000341048.4	-	12	1961	c.1810G>A	c.(1810-1812)Gaa>Aaa	p.E604K	ANKRD55_ENST00000434982.2_Missense_Mutation_p.E316K|ANKRD55_ENST00000504958.2_Missense_Mutation_p.E561K	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	603										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GCAGAATGTTCACTCTCTTCT	0.448000													38	86					0	0	1	0	0
LGALS3	3958	broad.mit.edu	37	14	55607035	55607035	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:55607035C>T	ENST00000254301.9	+	4	646	c.385C>T	c.(385-387)Cgc>Tgc	p.R129C	LGALS3_ENST00000553755.1_3'UTR|LGALS3_ENST00000554715.1_Missense_Mutation_p.R129C	NM_002306.3	NP_002297.2	P17931	LEG3_HUMAN	lectin, galactoside-binding, soluble, 3	129	Galectin.				cell differentiation|innate immune response|mRNA processing|RNA splicing	mitochondrial inner membrane|plasma membrane|spliceosomal complex	IgE binding|sugar binding			central_nervous_system(1)|endometrium(1)|prostate(1)	3						AGTGGTGCCTCGCATGCTGAT	0.413000													6	9					0	0	1	0	0
ZNF16	7564	broad.mit.edu	37	8	146156409	146156409	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:146156409G>A	ENST00000276816.4	-	4	1950	c.1764C>T	c.(1762-1764)ctC>ctT	p.L588L	ZNF16_ENST00000394909.2_Silent_p.L588L	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	588					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GGTGGTGAATGAGATTTGAGC	0.473000													19	42					0	0	1	0	0
MBTPS2	51360	broad.mit.edu	37	X	21861409	21861409	+	Missense_Mutation	SNP	G	G	A	rs5951639		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:21861409G>A	ENST00000365779.2	+	2	278	c.197G>A	c.(196-198)cGg>cAg	p.R66Q	MBTPS2_ENST00000379484.5_Missense_Mutation_p.R66Q|MBTPS2_ENST00000465888.1_3'UTR			O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase, site 2	66					cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			breast(2)|endometrium(3)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24						AGTTGGGGACGGCGGAAAGCA	0.413000													41	20					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101540693	101540693	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:101540693C>G	ENST00000353234.4	-	7	1429	c.1382G>C	c.(1381-1383)cGa>cCa	p.R461P	ANKS6_ENST00000375019.2_Missense_Mutation_p.R160P|ANKS6_ENST00000375018.1_Missense_Mutation_p.R461P|ANKS6_ENST00000540940.1_Missense_Mutation_p.R266P			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	461										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				ATTGGACATTCGGTTCCACCA	0.587000													17	26					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20067030	20067030	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:20067030C>T	ENST00000400230.2	-	3	123	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K	TPTE2_ENST00000382978.1_Missense_Mutation_p.E27K|TPTE2_ENST00000390680.2_Missense_Mutation_p.E27K|TPTE2_ENST00000255310.6_Missense_Mutation_p.E27K|TPTE2_ENST00000400103.2_Missense_Mutation_p.E27K|TPTE2_ENST00000382975.4_Missense_Mutation_p.E27K|TPTE2_ENST00000382977.4_Missense_Mutation_p.E27K|TPTE2_ENST00000457266.2_Missense_Mutation_p.E27K			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	27						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CCTTTAAATTCACTTGTGTGT	0.368000													20	79					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41566465	41566465	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:41566465G>A	ENST00000396942.1	-	17	1912	c.1829C>T	c.(1828-1830)gCc>gTc	p.A610V	ANK1_ENST00000347528.4_Missense_Mutation_p.A610V|ANK1_ENST00000265709.8_Missense_Mutation_p.A643V|ANK1_ENST00000352337.4_Missense_Mutation_p.A610V|ANK1_ENST00000379758.2_Missense_Mutation_p.A610V|ANK1_ENST00000396945.1_Missense_Mutation_p.A610V|ANK1_ENST00000289734.7_Missense_Mutation_p.A610V			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	610	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTTCTGCTTGGCAGCGATGTG	0.587000													29	67					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46261181	46261181	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:46261181C>T	ENST00000336378.4	+	19	1910	c.1792C>T	c.(1792-1794)Cag>Tag	p.Q598*	FAM21C_ENST00000537517.1_Nonsense_Mutation_p.Q574*|FAM21C_ENST00000540872.1_Nonsense_Mutation_p.Q598*|FAM21C_ENST00000359860.4_Nonsense_Mutation_p.Q542*|FAM21C_ENST00000374362.2_Nonsense_Mutation_p.Q598*	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	598										central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						TCTACAAGCTCAGAGAGAAGA	0.428000													60	104					0	0	1	0	0
FUT1	2523	broad.mit.edu	37	19	49254224	49254224	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:49254224G>A	ENST00000310160.3	-	4	1289	c.315C>T	c.(313-315)ctC>ctT	p.L105L		NM_000148.3	NP_000139.1	P19526	FUT1_HUMAN	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	105					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(3)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		GGCGGCCGTTGAGCTGGGCCA	0.652000													56	44					0	0	1	0	0
GABPB2	126626	broad.mit.edu	37	1	151063031	151063031	+	Silent	SNP	C	C	T	rs145720065		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:151063031C>T	ENST00000368918.3	+	3	589	c.258C>T	c.(256-258)atC>atT	p.I86I	GABPB2_ENST00000368916.1_Silent_p.I86I|GABPB2_ENST00000368917.1_Silent_p.I86I	NM_144618.2	NP_653219.1	Q8TAK5	GABP2_HUMAN	GA binding protein transcription factor, beta subunit 2	86					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(3)|liver(2)|lung(7)	15				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		ATGCGCACATCGTGGAACTGC	0.488000													33	41					0	0	1	0	0
HOXA2	3199	broad.mit.edu	37	7	27141045	27141045	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:27141045C>T	ENST00000222718.5	-	2	741	c.431G>A	c.(430-432)cGg>cAg	p.R144Q		NM_006735.3	NP_006726.1	O43364	HXA2_HUMAN	homeobox A2	144						nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|cervix(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	22						TCTCAGGCGCCGCGATCCCCC	0.552000													34	22					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52568376	52568376	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:52568376G>C	ENST00000389534.4	-	7	3218	c.2759C>G	c.(2758-2760)tCt>tGt	p.S920C	ZNF841_ENST00000594295.1_Missense_Mutation_p.S920C|ZNF841_ENST00000426391.2_Missense_Mutation_p.S804C|ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Missense_Mutation_p.S496C	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	804					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						GGGGATCCCAGAGGTTAGGAC	0.393000													11	21					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4924782	4924782	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:4924782C>T	ENST00000396658.4	+	14	3074	c.2371C>T	c.(2371-2373)Cac>Tac	p.H791Y	UBN1_ENST00000590769.1_Missense_Mutation_p.H791Y|UBN1_ENST00000262376.6_Missense_Mutation_p.H791Y|UBN1_ENST00000545171.1_Missense_Mutation_p.H791Y	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	791					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity	p.H791Y(1)		NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						ACGGACGTCTCACGGGCCCCA	0.572000													33	143					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871699	149871699	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:149871699C>T	ENST00000369153.2	+	3	751	c.87C>T	c.(85-87)atC>atT	p.I29I	BOLA1_ENST00000476344.1_3'UTR|BOLA1_ENST00000369152.5_Silent_p.I29I|BOLA1_ENST00000369150.1_Silent_p.I29I			Q9Y3E2	BOLA1_HUMAN	bolA family member 1	29						extracellular region	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	10	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCGGGGCCATCGGTCCGGTGG	0.692000													33	37					0	0	1	0	0
KRT10	3858	broad.mit.edu	37	17	38975878	38975878	+	Silent	SNP	G	G	T	rs59075499		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:38975878G>T	ENST00000269576.5	-	6	1273	c.1264C>A	c.(1264-1266)Cga>Aga	p.R422R	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412	P13645	K1C10_HUMAN	keratin 10	422	Coil 2.|Gly-rich.|Rod.		R -> E (in AEI; requires 2 nucleotide substitutions; dbSNP:rs59075499).		epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				GTTTCAGCTCGAATCTGTTGC	0.493000													43	64					5.44703e-19	5.6611e-19	1	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3670736	3670736	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:3670736G>C	ENST00000344754.4	-	18	4766	c.4767C>G	c.(4765-4767)gtC>gtG	p.V1589V	SIGLEC1_ENST00000202578.4_Silent_p.V1589V	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1589	Ig-like C2-type 16.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGGAAGCCAGGACATGGATGT	0.632000													13	18					0	0	1	0	0
SNX7	51375	broad.mit.edu	37	1	99161081	99161081	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:99161081C>T	ENST00000370189.5	+	6	819	c.455C>T	c.(454-456)tCt>tTt	p.S152F	SNX7_ENST00000306121.3_Missense_Mutation_p.S216F|SNX7_ENST00000529992.1_Missense_Mutation_p.S161F			Q9UNH6	SNX7_HUMAN	sorting nexin 7	152					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		TAGGAACTCTCTTCTCACAAG	0.413000													21	37					0	0	1	0	0
POC5	134359	broad.mit.edu	37	5	74973633	74973633	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:74973633G>A	ENST00000428202.2	-	11	1739	c.1550C>T	c.(1549-1551)tCa>tTa	p.S517L	POC5_ENST00000510798.1_Intron|POC5_ENST00000514838.2_Missense_Mutation_p.S489L|POC5_ENST00000446329.2_Missense_Mutation_p.S492L|POC5_ENST00000380475.2_Intron	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	517					cell cycle	centriole				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CACAACAACTGAGCTCATGGG	0.393000													20	31					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73945896	73945896	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:73945896G>A	ENST00000537812.1	-	10	1915	c.1267C>T	c.(1267-1269)Cag>Tag	p.Q423*	ACOX1_ENST00000301608.4_Nonsense_Mutation_p.Q461*|ACOX1_ENST00000293217.5_Nonsense_Mutation_p.Q461*	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	461					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						TGGATGCGCTGACTGGGCAGG	0.507000													34	55					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445755	49445755	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:49445755G>A	ENST00000301067.7	-	10	1710	c.1711C>T	c.(1711-1713)Cgc>Tgc	p.R571C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGAGACAGGCGAGATGCTTCA	0.592000													5	184					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714458	38714458	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:38714458C>T	ENST00000308742.4	+	3	1181	c.865C>T	c.(865-867)Cct>Tct	p.P289S	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	289					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCTTCATTTTCCTCAACTATT	0.363000													27	100					0	0	1	0	0
METTL2B	55798	broad.mit.edu	37	7	128119542	128119542	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:128119542C>T	ENST00000480046.1	+	2	453	c.338C>T	c.(337-339)tCc>tTc	p.S113F	METTL2B_ENST00000473488.1_3'UTR|RP11-212P7.3_ENST00000462662.1_RNA|METTL2B_ENST00000262432.8_Missense_Mutation_p.S178F			Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	178							methyltransferase activity			breast(1)|cervix(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						TTTCCTGGATCCTCAGCCACC	0.428000													14	75					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15935647	15935647	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:15935647G>A	ENST00000268712.3	-	46	7543	c.7286C>T	c.(7285-7287)tCa>tTa	p.S2429L	NCOR1_ENST00000395851.1_Missense_Mutation_p.S2326L|NCOR1_ENST00000395857.3_Missense_Mutation_p.S1013L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2429	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTACTGTGCTGAGAGCAGTGG	0.532000													29	17					0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74074826	74074826	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:74074826C>T	ENST00000394070.2	+	5	1191	c.688C>T	c.(688-690)Cca>Tca	p.P230S	STAMBP_ENST00000339566.3_Missense_Mutation_p.P230S|STAMBP_ENST00000409707.1_Missense_Mutation_p.P230S|STAMBP_ENST00000536064.1_Intron|STAMBP_ENST00000394073.1_Missense_Mutation_p.P230S	NM_213622.2	NP_998787.1	O95630	STABP_HUMAN	STAM binding protein	230	Interaction with STAM1.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	18						GCCAGCTAAGCCACCTGTGGT	0.498000													20	73					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137341245	137341245	+	Silent	SNP	G	G	A	rs139929349		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:137341245G>A	ENST00000424189.2	-	4	877	c.648C>T	c.(646-648)gtC>gtT	p.V216V	DGKI_ENST00000446122.1_Silent_p.V216V|DGKI_ENST00000453654.2_5'UTR|DGKI_ENST00000288490.5_Silent_p.V216V			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	216					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CGGTGTGGACGACGATTTTAC	0.443000											OREG0018350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	168					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4409482	4409482	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:4409482G>A	ENST00000301280.5	+	3	787	c.686G>A	c.(685-687)gGg>gAg	p.G229E		NM_005483.2	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	229	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGAAGCTGGGGGCATCCTG	0.597000								Chromatin Structure					25	60					0	0	1	0	0
CCPG1	9236	broad.mit.edu	37	15	55651928	55651928	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:55651928G>C	ENST00000310958.6	-	8	2341	c.2043C>G	c.(2041-2043)atC>atG	p.I681M	CCPG1_ENST00000425574.3_Intron|CCPG1_ENST00000569205.1_Missense_Mutation_p.I681M|DYX1C1-CCPG1_ENST00000565113.1_RNA|CCPG1_ENST00000442196.3_Missense_Mutation_p.I681M	NM_001204450.1|NM_001204451.1|NM_004748.4|NM_020739.3	NP_001191379.1|NP_001191380.1|NP_004739.3|NP_065790.2	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1	681					cell cycle	integral to membrane				autonomic_ganglia(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|stomach(3)	30				all cancers(107;0.0354)		AAAACTTATTGATGAACTGAT	0.318000													12	41					0	0	1	0	0
TCF19	6941	broad.mit.edu	37	6	31127452	31127452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31127452G>A	ENST00000376257.3	+	2	960	c.206G>A	c.(205-207)tGg>tAg	p.W69*	TCF19_ENST00000376255.4_Nonsense_Mutation_p.W69*	NM_007109.2	NP_009040.2	Q9Y242	TCF19_HUMAN	transcription factor 19	69	FHA.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						GGTGATGACTGGAGGGTCAGC	0.637000													18	32					0	0	1	0	0
TDP2	51567	broad.mit.edu	37	6	24651197	24651197	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:24651197G>A	ENST00000341060.3	-	6	1129	c.734C>T	c.(733-735)tCt>tTt	p.S245F	TDP2_ENST00000545995.1_Missense_Mutation_p.S333F|TDP2_ENST00000378198.4_Missense_Mutation_p.S303F			O95551	TYDP2_HUMAN	tyrosyl-DNA phosphodiesterase 2	303					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			kidney(2)|large_intestine(1)|lung(5)|ovary(1)	9						TCCAAGATTAGAGTTCATTTG	0.413000								Direct reversal of damage					11	36					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	88035633	88035633	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:88035633G>C	ENST00000307808.6	+	11	2047	c.1627G>C	c.(1627-1629)Gag>Cag	p.E543Q	AFF1_ENST00000544085.1_Missense_Mutation_p.E181Q|AFF1_ENST00000395146.4_Missense_Mutation_p.E550Q	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	543						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCGGCACCCAGAGAGTAAGGG	0.622000													13	27					0	0	1	0	0
PAQR8	85315	broad.mit.edu	37	6	52268222	52268222	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:52268222C>T	ENST00000442253.2	+	2	385	c.211C>T	c.(211-213)Cag>Tag	p.Q71*	PAQR8_ENST00000360726.3_Nonsense_Mutation_p.Q71*	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	71					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					CAGCCTCTTTCAGAAACACAA	0.612000													30	64					0	0	1	0	0
TRBV5-7	28608	broad.mit.edu	37	7	142111625	142111625	+	RNA	SNP	G	G	T	rs143168323	by1000genomes	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:142111625G>T	ENST00000390378.1	-	0	110																											TCAGAGTCACGTGCTGTCCTC	0.532000													5	183					5.68852e-11	5.83564e-11	1	1	0
IP6K2	51447	broad.mit.edu	37	3	48726174	48726174	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:48726174G>A	ENST00000328631.5	-	6	1036	c.813C>T	c.(811-813)ttC>ttT	p.F271F		NM_001005909.2|NM_016291.3	NP_001005909.1|NP_057375.2	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	271					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						ACTTGTTCATGAACATGAGCT	0.592000													23	85					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55992896	55992896	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:55992896C>T	ENST00000598519.1	+	3	889	c.336C>T	c.(334-336)agC>agT	p.S112S	ZNF628_ENST00000391718.2_Silent_p.S108S			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	108						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		TCCACCGTAGCGTGCACACCG	0.657000													16	42					0	0	1	0	0
TNFAIP8	25816	broad.mit.edu	37	5	118728704	118728704	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:118728704C>T	ENST00000504771.2	+	2	2002	c.225C>T	c.(223-225)ctC>ctT	p.L75L	TNFAIP8_ENST00000513374.1_Silent_p.L87L|TNFAIP8_ENST00000504642.1_Silent_p.L77L|TNFAIP8_ENST00000274456.6_Silent_p.L65L|TNFAIP8_ENST00000415806.2_3'UTR|TNFAIP8_ENST00000503646.1_Silent_p.L75L	NM_014350.2	NP_055165.2	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	75					anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		TCAAGAACCTCATCAAGACAG	0.413000													16	23					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52991561	52991561	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:52991561G>A	ENST00000371544.3	-	2	654	c.392C>T	c.(391-393)tCa>tTa	p.S131L	ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000355809.4_Missense_Mutation_p.S131L|ZCCHC11_ENST00000257177.4_Missense_Mutation_p.S131L	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	131					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TGACTTTGGTGATTTTTCTGC	0.408000													35	103					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44698875	44698875	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:44698875C>T	ENST00000290231.6	-	3	503	c.339G>A	c.(337-339)atG>atA	p.M113I		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	113	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				GGGAGTCTCTCATGTCTCTGT	0.428000													27	36					0	0	1	0	0
RND3	390	broad.mit.edu	37	2	151343784	151343784	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:151343784C>T	ENST00000375734.2	-	1	397	c.148G>A	c.(148-150)Gag>Aag	p.E50K	RND3_ENST00000263895.4_Missense_Mutation_p.E50K	NM_001254738.1	NP_001241667.1	P61587	RND3_HUMAN	Rho family GTPase 3	50					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.106)		ACACTCACCTCGGGGAAGCAG	0.577000													10	11					0	0	1	0	0
AIMP1	9255	broad.mit.edu	37	4	107246142	107246142	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:107246142G>C	ENST00000394701.4	+	2	89	c.48G>C	c.(46-48)atG>atC	p.M16I	AIMP1_ENST00000358008.3_5'UTR|AIMP1_ENST00000442366.1_5'UTR	NM_001142416.1	NP_001135888.1	Q12904	AIMP1_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	0	Required for fibroblast proliferation.				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding			breast(1)|endometrium(2)|kidney(1)|lung(5)|skin(1)|urinary_tract(1)	11						TTTCCTATAGGATTTTCTGCC	0.348000													7	11					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151138851	151138851	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:151138851G>A	ENST00000370325.1	-	2	133	c.80C>T	c.(79-81)tCa>tTa	p.S27L	GABRE_ENST00000393914.3_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.S27L			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	27					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TTCATTCTTTGATTCAGTCTG	0.522000													62	35					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33239358	33239358	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:33239358C>T	ENST00000482399.1	-	1	295	c.95G>A	c.(94-96)aGa>aAa	p.R32K	VPS52_ENST00000445902.2_Intron|VPS52_ENST00000478934.1_Intron|VPS52_ENST00000436044.2_Intron			Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	0					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						GCTCCGCGCTCTCACCAGCGG	0.642000													5	7					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47894729	47894729	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:47894729G>A	ENST00000426837.2	-	20	6897	c.6810C>T	c.(6808-6810)ctC>ctT	p.L2270L	MAP4_ENST00000264724.11_Silent_p.L860L|MAP4_ENST00000360240.6_Silent_p.L1125L|MAP4_ENST00000383737.4_Silent_p.L784L|MAP4_ENST00000420772.2_Intron|MAP4_ENST00000395734.3_Intron|MAP4_ENST00000441748.2_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	1125					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GGTGGCCATTGAGGCCACTGG	0.667000													39	59					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75280779	75280779	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:75280779C>T	ENST00000305249.5	-	3	1453	c.688G>A	c.(688-690)Ggg>Agg	p.G230R	TACR1_ENST00000409848.3_Missense_Mutation_p.G230R	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	GAGGAGTCCCCGGGGATCTCA	0.577000											OREG0014726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	24					0	0	1	0	0
TMEM109	79073	broad.mit.edu	37	11	60689575	60689575	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:60689575G>C	ENST00000227525.3	+	4	1073	c.670G>C	c.(670-672)Gag>Cag	p.E224Q	TMEM109_ENST00000536171.1_Missense_Mutation_p.E224Q|RP11-881M11.4_ENST00000543907.1_RNA	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	224						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						ACGCCAGGTGGAGGAGCTGCG	0.687000													8	22					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935399	56935399	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:56935399C>A	ENST00000333201.9	+	5	1582	c.1372C>A	c.(1372-1374)Cat>Aat	p.H458N	ZNF583_ENST00000291598.7_Missense_Mutation_p.H458N|ZNF583_ENST00000585612.1_Intron	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TCAGAGAAGTCATACTGGAGA	0.408000													24	84					1.9806e-07	2.01589e-07	1	1	0
BIRC6	57448	broad.mit.edu	37	2	32626664	32626664	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:32626664C>T	ENST00000421745.2	+	8	1525	c.1391C>T	c.(1390-1392)tCa>tTa	p.S464L		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	464					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TCTAGTTGCTCAGATATACCA	0.378000													43	54					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172080474	172080474	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:172080474C>T	ENST00000336824.4	+	23	2946	c.2847C>T	c.(2845-2847)ttC>ttT	p.F949F	FNDC3B_ENST00000416957.1_Silent_p.F949F|FNDC3B_ENST00000415807.2_Silent_p.F949F	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	949	Fibronectin type-III 7.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTAGTCAGTTCATTAAAGCAA	0.433000													25	52					0	0	1	0	0
ORC6	23594	broad.mit.edu	37	16	46726423	46726423	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:46726423G>A	ENST00000566860.1	+	2	465	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	ORC6_ENST00000219097.2_Missense_Mutation_p.E109K|ORC6_ENST00000568364.2_Missense_Mutation_p.E109K			Q9Y5N6	ORC6_HUMAN	origin recognition complex, subunit 6	109					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA binding|protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	8						TAGCTGTATAGAAGCAGTGAA	0.413000													20	77					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46321035	46321035	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:46321035G>A	ENST00000465950.1	-	1	2713	c.1504C>T	c.(1504-1506)Cca>Tca	p.P502S	SCAF11_ENST00000369367.3_Missense_Mutation_p.P817S|SCAF11_ENST00000419565.2_Missense_Mutation_p.P817S|SCAF11_ENST00000549162.1_Missense_Mutation_p.P625S			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	817					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						CTGGGAGATGGAGACTGGGGC	0.468000													18	63					0	0	1	0	0
DUSP12	11266	broad.mit.edu	37	1	161719828	161719828	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161719828C>T	ENST00000367943.4	+	1	269	c.237C>T	c.(235-237)ttC>ttT	p.F79F		NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	79					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GGCGCCTCTTCGTGCCAGCGC	0.662000													27	90					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640393	3640393	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:3640393C>T	ENST00000294008.3	-	12	3886	c.3246G>A	c.(3244-3246)caG>caA	p.Q1082Q		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1082	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						TGTCCCTTTTCTGCTTTGATG	0.587000								Direct reversal of damage					41	142					0	0	1	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87162411	87162411	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:87162411G>A	ENST00000285393.3	+	6	852	c.710G>A	c.(709-711)cGa>cAa	p.R237Q	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	237					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						AAAGAAGACCGAGAGACCCTC	0.463000													20	56					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176860605	176860605	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:176860605C>T	ENST00000355472.5	+	8	834	c.666C>T	c.(664-666)atC>atT	p.I222I	GRK6_ENST00000355958.5_Silent_p.I222I|GRK6_ENST00000393576.3_Silent_p.I222I|GRK6_ENST00000507633.1_Silent_p.I222I|GRK6_ENST00000528793.1_Silent_p.I222I	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	222	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAAAGCGGATCAAGAAGCGGA	0.557000													43	56					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79517476	79517476	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:79517476G>A	ENST00000537152.1	-	3	1116	c.591C>T	c.(589-591)ctC>ctT	p.L197L	C17orf70_ENST00000327787.8_Silent_p.L348L	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	348					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGGCAGCGCAGAGCACAGGGC	0.682000													31	55					0	0	1	0	0
C6orf62	81688	broad.mit.edu	37	6	24714636	24714636	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:24714636G>A	ENST00000378119.4	-	3	2506	c.339C>T	c.(337-339)ttC>ttT	p.F113F	C6orf62_ENST00000540769.1_Silent_p.F55F|C6orf62_ENST00000378102.3_Silent_p.F84F	NM_030939.4	NP_112201.1	Q9GZU0	CF062_HUMAN	chromosome 6 open reading frame 62	113						intracellular				endometrium(2)|kidney(3)|large_intestine(2)|lung(3)	10						GCCAAAGAATGAAATCCATCT	0.348000													31	33					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414660	121414660	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:121414660G>A	ENST00000393667.3	-	13	4820	c.4710C>T	c.(4708-4710)ctC>ctT	p.L1570L	GOLGB1_ENST00000340645.5_Silent_p.L1565L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1565					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		AGGAGCTGCTGAGACTCTGAT	0.368000													42	79					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46916341	46916341	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:46916341G>A	ENST00000378623.1	-	12	1581	c.1339C>T	c.(1339-1341)Cgc>Tgc	p.R447C		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	447					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		ATGTCGATGCGATTGGCGAAC	0.572000													25	57					0	0	1	0	0
RHOV	171177	broad.mit.edu	37	15	41165271	41165271	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:41165271G>A	ENST00000220507.4	-	3	845	c.696C>T	c.(694-696)ttC>ttT	p.F232F		NM_133639.3	NP_598378.3	Q96L33	RHOV_HUMAN	ras homolog family member V	232					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding			central_nervous_system(1)|large_intestine(1)	2		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CGAAGCAGAAGAACTTCTTCC	0.567000													37	37					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42175234	42175234	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:42175234C>T	ENST00000520810.1	+	12	1371	c.1185C>T	c.(1183-1185)atC>atT	p.I395I	IKBKB_ENST00000416505.2_Silent_p.I336I|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000379708.3_Silent_p.I172I|IKBKB_ENST00000520835.1_Silent_p.I393I	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	395					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ACAGTAAAATCACCTATGAGA	0.393000													18	52					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89083213	89083213	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:89083213C>T	ENST00000554922.1	-	42	5901	c.5653G>A	c.(5653-5655)Gat>Aat	p.D1885N	EML5_ENST00000352093.5_Missense_Mutation_p.D1839N|EML5_ENST00000380664.5_Missense_Mutation_p.D1877N	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1877						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						AAAACCTCATCTCCTAGAATA	0.413000													25	46					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140657180	140657180	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:140657180C>T	ENST00000460843.1	+	10	1582	c.1555C>T	c.(1555-1557)Ctc>Ttc	p.L519F	EHMT1_ENST00000371394.2_3'UTR|EHMT1_ENST00000334856.6_Missense_Mutation_p.L488F|EHMT1_ENST00000462484.1_Missense_Mutation_p.L519F	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	519					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GGAAGTGCCTCTCTGCAGCTG	0.552000													25	51					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50264936	50264936	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:50264936C>G	ENST00000284509.6	-	13	1227	c.1086G>C	c.(1084-1086)aaG>aaC	p.K362N	ATP8B4_ENST00000559829.1_Missense_Mutation_p.K362N	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	362					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AATAATACATCTTCCGGTCCC	0.398000													14	61					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31333818	31333818	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:31333818C>G	ENST00000397641.3	-	14	1761	c.1353G>C	c.(1351-1353)tgG>tgC	p.W451C	MORC2_ENST00000215862.4_Missense_Mutation_p.W389C|MORC2_ENST00000469915.1_Intron			Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2								ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CAATATCCTTCCAATACTGCG	0.557000													31	79					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209302336	209302336	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:209302336C>G	ENST00000272847.2	+	3	466	c.253C>G	c.(253-255)Cca>Gca	p.P85A	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	85						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		ATCGGCTGTTCCATGCCCTCC	0.323000													18	13					0	0	1	0	0
TNNT1	7138	broad.mit.edu	37	19	55652617	55652617	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:55652617G>C	ENST00000588981.1	-	8	450	c.246C>G	c.(244-246)atC>atG	p.I82M	TNNT1_ENST00000536926.1_Missense_Mutation_p.I71M|TNNT1_ENST00000291901.8_Missense_Mutation_p.I82M|TNNT1_ENST00000356783.5_Missense_Mutation_p.I71M|TNNT1_ENST00000588426.1_Intron|TNNT1_ENST00000585321.2_Missense_Mutation_p.I12M|TNNT1_ENST00000587465.2_Missense_Mutation_p.I12M|TNNT1_ENST00000587758.1_Missense_Mutation_p.I71M|TNNT1_ENST00000592920.1_5'UTR	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	82					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding	p.I82I(1)		endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		AATGTACATCGATGAGTGTCT	0.612000											OREG0025677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	76					0	0	1	0	0
NR4A2	4929	broad.mit.edu	37	2	157182448	157182448	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:157182448G>C	ENST00000409108.2	-	8	1542	c.1501C>G	c.(1501-1503)Caa>Gaa	p.Q501E	NR4A2_ENST00000409572.1_Silent_p.L535L|NR4A2_ENST00000339562.4_Silent_p.L535L|NR4A2_ENST00000539077.1_Silent_p.L546L|NR4A2_ENST00000426264.1_Silent_p.L472L|NR4A2_ENST00000429376.1_Missense_Mutation_p.Q438E			P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	0					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						CGTGGTCTTTGAGACAATTTA	0.448000													71	44					0	0	1	0	0
DUSP2	1844	broad.mit.edu	37	2	96809639	96809639	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:96809639G>A	ENST00000288943.4	-	4	953	c.868C>T	c.(868-870)Cgc>Tgc	p.R290C		NM_004418.3	NP_004409.1	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	290	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			NS(1)|breast(1)|lung(2)|skin(1)	5		Ovarian(717;0.0228)				ACCCCCCGGCGCTGCTTAACG	0.622000													25	24					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5012624	5012624	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:5012624G>C	ENST00000380390.1	+	5	709	c.493G>C	c.(493-495)Gat>Cat	p.D165H	MMP26_ENST00000300762.1_Missense_Mutation_p.D165H			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	165					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TTGGCCCTTTGATGGGCCAGG	0.463000													86	190					0	0	1	0	0
RPUSD3	285367	broad.mit.edu	37	3	9885262	9885262	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:9885262G>C	ENST00000383820.5	-	2	150	c.149C>G	c.(148-150)tCc>tGc	p.S50C	RPUSD3_ENST00000424438.1_Missense_Mutation_p.S18C|RPUSD3_ENST00000485705.1_5'UTR|RPUSD3_ENST00000433535.2_Missense_Mutation_p.S50C|TTLL3_ENST00000455274.1_Intron	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	50					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					CCGTTGGCAGGAGCCGCGGGG	0.657000													14	39					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14037518	14037518	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:14037518G>C	ENST00000318003.7	+	19	2294	c.2053G>C	c.(2053-2055)Gac>Cac	p.D685H	CC2D1A_ENST00000589606.1_Missense_Mutation_p.D685H	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	685	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			TGTTCGGTTTGACTTCCCCTA	0.622000													51	110					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21331609	21331609	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:21331609C>G	ENST00000256958.2	+	6	677	c.581C>G	c.(580-582)tCt>tGt	p.S194C		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	194					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TTGGGGCTTTCTTACATTGAT	0.358000													21	49					0	0	1	0	0
FUZ	80199	broad.mit.edu	37	19	50310454	50310454	+	Missense_Mutation	SNP	C	C	T	rs137955120	by1000genomes	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:50310454C>T	ENST00000313777.4	-	11	1374	c.1211G>A	c.(1210-1212)cGa>cAa	p.R404Q	FUZ_ENST00000445575.2_Intron|FUZ_ENST00000528094.1_Missense_Mutation_p.R368Q|FUZ_ENST00000533418.1_Missense_Mutation_p.R354Q	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	404	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		GGCCAGGCTTCGCAGCCCATG	0.617000													33	57					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	592473	592473	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:592473C>T	ENST00000230449.4	-	11	1323	c.1188G>A	c.(1186-1188)ctG>ctA	p.L396L	EXOC2_ENST00000448181.3_Intron	NM_018303.5	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	396					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		CCTTGCCTTTCAGATCTTTCA	0.443000													10	35					0	0	1	0	0
NUP50	10762	broad.mit.edu	37	22	45574572	45574572	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:45574572G>T	ENST00000347635.4	+	5	1260	c.794G>T	c.(793-795)gGa>gTa	p.G265V	NUP50_ENST00000425733.2_Missense_Mutation_p.G15V|NUP50_ENST00000396096.2_Missense_Mutation_p.G237V|NUP50_ENST00000407019.2_Missense_Mutation_p.G237V	NM_007172.3	NP_009103.2	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa		5 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TCATCACTAGGAGCGACAAGT	0.443000													12	29					9.05144e-12	9.31229e-12	1	1	0
SETX	23064	broad.mit.edu	37	9	135205093	135205093	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:135205093G>A	ENST00000372169.2	-	10	2074	c.1892C>T	c.(1891-1893)tCt>tTt	p.S631F	SETX_ENST00000224140.5_Missense_Mutation_p.S631F|SETX_ENST00000393220.1_Missense_Mutation_p.S631F			Q7Z333	SETX_HUMAN	senataxin	631					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATCTTTTCTAGACGTCTTCCC	0.368000													13	47					0	0	1	0	0
CCDC176	80127	broad.mit.edu	37	14	74516525	74516525	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:74516525G>A	ENST00000394009.3	+	8	1036	c.913G>A	c.(913-915)Gag>Aag	p.E305K	AC005484.5_ENST00000492026.1_RNA|CCDC176_ENST00000553773.1_Missense_Mutation_p.E30K	NM_025057.2	NP_079333.2			coiled-coil domain containing 176																		CATGACCAAAGAGTTTGAGAG	0.413000													15	48					0	0	1	0	0
HAND1	9421	broad.mit.edu	37	5	153857471	153857471	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:153857471G>A	ENST00000231121.2	-	1	353	c.98C>T	c.(97-99)tCg>tTg	p.S33L		NM_004821.2	NP_004812.1	O96004	HAND1_HUMAN	heart and neural crest derivatives expressed 1	33					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			ATGACAGCGCGAGGCCGGACC	0.687000													35	101					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7817736	7817736	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:7817736G>A	ENST00000379562.4	-	6	632	c.585C>T	c.(583-585)agC>agT	p.S195S	KIN_ENST00000535925.1_Silent_p.S195S|KIN_ENST00000543003.1_Silent_p.S89S	NM_012311.3	NP_036443.1	O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)						DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						CATTTTCTCTGCTTAATTCCG	0.284000													7	23					0	0	1	0	0
C15orf52	388115	broad.mit.edu	37	15	40627489	40627489	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:40627489G>A	ENST00000397536.2	-	7	880	c.845C>T	c.(844-846)tCt>tTt	p.S282F	C15orf52_ENST00000559313.1_Missense_Mutation_p.S492F			Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	492										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		AGACTTGCCAGACCTGTCTTC	0.662000													94	81					0	0	1	0	0
DVL1	1855	broad.mit.edu	37	1	1277116	1277116	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:1277116G>A	ENST00000378888.5	-	5	820	c.536C>T	c.(535-537)tCc>tTc	p.S179F	DVL1_ENST00000378891.5_Missense_Mutation_p.S179F			O14640	DVL1_HUMAN	dishevelled segment polarity protein 1	179					canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GAGGGCGGTGGACGCGCTGTC	0.672000													5	13					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33586669	33586669	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:33586669G>A	ENST00000299977.4	+	2	1108	c.960G>A	c.(958-960)gtG>gtA	p.V320V	SLFN5_ENST00000592325.1_Silent_p.V320V|SLFN5_ENST00000542451.1_Silent_p.V320V	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	320					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		ACAACCGTGTGAGACAATTGC	0.512000													37	92					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60646244	60646244	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:60646244G>T	ENST00000400316.4	+	17	4979	c.3198G>T	c.(3196-3198)gaG>gaT	p.E1066D	PHLPP1_ENST00000262719.5_Missense_Mutation_p.E1578D	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1578					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						AGGAGAAGGAGAAACAGCAGC	0.612000													17	21					9.16793e-09	9.35129e-09	1	1	0
TTC39B	158219	broad.mit.edu	37	9	15188060	15188060	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:15188060C>T	ENST00000512701.2	-	14	1340	c.1304G>A	c.(1303-1305)tGg>tAg	p.W435*	TTC39B_ENST00000507285.1_Nonsense_Mutation_p.W270*|TTC39B_ENST00000297615.5_Nonsense_Mutation_p.W366*|TTC39B_ENST00000380850.4_Nonsense_Mutation_p.W422*|TTC39B_ENST00000355694.2_Nonsense_Mutation_p.W369*|TTC39B_ENST00000507993.1_Nonsense_Mutation_p.W270*			Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B								binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)	21						CATTAGCTCCCAGTAGCAGAG	0.378000													18	55					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21767043	21767043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:21767043G>A	ENST00000276420.4	-	5	1276	c.1018C>T	c.(1018-1020)Cga>Tga	p.R340*	DOK2_ENST00000544659.1_Nonsense_Mutation_p.R186*	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	340	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TGGTCAGGTCGAGGGGGCAGG	0.647000													40	69					0	0	1	0	0
NR1I2	8856	broad.mit.edu	37	3	119528977	119528977	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:119528977G>C	ENST00000393716.2	+	3	2106	c.267G>C	c.(265-267)aaG>aaC	p.K89N	NR1I2_ENST00000337940.4_Missense_Mutation_p.K128N|NR1I2_ENST00000466380.1_Missense_Mutation_p.K89N	NM_003889.3	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	89					drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	TCACCCGGAAGACCCGGCGAC	0.701000													17	36					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85636514	85636514	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:85636514G>C	ENST00000322366.6	-	49	8254	c.7847C>G	c.(7846-7848)tCt>tGt	p.S2616C	WDFY3_ENST00000295888.4_Missense_Mutation_p.S2633C			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2633						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCATCTCCAGAGAAAACTTC	0.323000													24	48					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139603669	139603669	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:139603669G>A	ENST00000303045.6	-	64	5137	c.4691C>T	c.(4690-4692)cCa>cTa	p.P1564L	COL22A1_ENST00000435777.1_Missense_Mutation_p.P1544L|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1564	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGTCATACCTGGGATTCCAGG	0.607000										HNSCC(7;0.00092)			5	12					0	0	1	0	0
DBR1	51163	broad.mit.edu	37	3	137881101	137881101	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:137881101G>A	ENST00000260803.4	-	8	1418	c.1265C>T	c.(1264-1266)tCt>tTt	p.S422F	DBR1_ENST00000505015.2_Missense_Mutation_p.S188F	NM_016216.3	NP_057300.2	Q9UK59	DBR1_HUMAN	debranching RNA lariats 1	422						nucleus	metal ion binding|RNA lariat debranching enzyme activity			NS(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						ATTAATAGAAGACAGAGCAGA	0.378000													19	36					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64159308	64159308	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:64159308G>A	ENST00000395254.3	+	5	1264	c.984G>A	c.(982-984)tcG>tcA	p.S328S	ZNF365_ENST00000410046.3_Intron|ZNF365_ENST00000466727.1_3'UTR|ZNF365_ENST00000395255.3_Intron	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0								p.S328S(1)		breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					ACCCGCATTCGGTATGTAACC	0.498000													166	111					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202255	248202255	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:248202255C>T	ENST00000366479.2	+	1	782	c.686C>T	c.(685-687)tCt>tTt	p.S229F	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CGCATGCACTCTGCAGAAGGG	0.488000													44	106					0	0	1	0	0
EIF2S1	1965	broad.mit.edu	37	14	67847384	67847384	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:67847384C>T	ENST00000256383.4	+	5	943	c.482C>T	c.(481-483)tCt>tTt	p.S161F	EIF2S1_ENST00000466499.2_Missense_Mutation_p.S161F	NM_004094.4	NP_004085.1	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	161						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		AGAGACCCATCTATTTTGGAT	0.333000													28	25					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59989042	59989042	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:59989042G>A	ENST00000444766.3	-	7	892	c.817C>T	c.(817-819)Cac>Tac	p.H273Y	INTS2_ENST00000251334.6_Missense_Mutation_p.H265Y	NM_020748.2	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	273					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						CCTGGCAAGTGACATTCTTCC	0.388000													12	12					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69727328	69727328	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:69727328C>G	ENST00000349945.1	+	14	4870	c.3318C>G	c.(3316-3318)ttC>ttG	p.F1106L	NFAT5_ENST00000567239.1_Missense_Mutation_p.F1199L|NFAT5_ENST00000393742.2_Missense_Mutation_p.F1106L|NFAT5_ENST00000566899.1_Missense_Mutation_p.F1106L|NFAT5_ENST00000354436.2_Missense_Mutation_p.F1182L|NFAT5_ENST00000432919.1_Missense_Mutation_p.F1200L	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1182					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AAGCTGCTTTCCAACAGCAAG	0.478000													34	97					0	0	1	0	0
NUPL1	9818	broad.mit.edu	37	13	25876001	25876001	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:25876001C>T	ENST00000463407.1	+	1	233	c.90C>T	c.(88-90)ttC>ttT	p.F30F	NUPL1_ENST00000466694.1_3'UTR|NUPL1_ENST00000381736.3_Silent_p.F30F|NUPL1_ENST00000381718.3_Silent_p.F30F			Q9BVL2	NUPL1_HUMAN	nucleoporin like 1	30	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|stomach(1)|urinary_tract(1)	16		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		TTTTCTCCTTCGGAACGGGAG	0.667000													11	9					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126091032	126091032	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:126091032G>A	ENST00000318410.7	-	6	1008	c.659C>T	c.(658-660)tCc>tTc	p.S220F	KIAA0196_ENST00000517845.1_Missense_Mutation_p.S72F	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	220					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			ACTGATGAAGGATTCGTTGAT	0.413000													25	62					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128109130	128109130	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:128109130C>T	ENST00000470056.1	+	17	3158	c.2998C>T	c.(2998-3000)Cag>Tag	p.Q1000*	GAPVD1_ENST00000312123.9_Nonsense_Mutation_p.Q1006*|GAPVD1_ENST00000394105.2_Nonsense_Mutation_p.Q1054*|GAPVD1_ENST00000495955.1_Nonsense_Mutation_p.Q1027*|GAPVD1_ENST00000265956.4_Nonsense_Mutation_p.Q1001*|GAPVD1_ENST00000394083.2_Nonsense_Mutation_p.Q979*|GAPVD1_ENST00000394104.2_Nonsense_Mutation_p.Q1027*|GAPVD1_ENST00000297933.6_Nonsense_Mutation_p.Q1027*			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1027					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TGCACAAGCTCAGGTGGCTGA	0.473000													23	25					0	0	1	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158517	26158517	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:26158517G>A	ENST00000289316.2	+	1	144	c.120G>A	c.(118-120)gtG>gtA	p.V40V	HIST1H2BD_ENST00000377777.4_Silent_p.V40V	NM_138720.2	NP_619790.1	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	40					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	24						GCTATTCAGTGTATGTGTACA	0.552000													10	242					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76372980	76372980	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:76372980C>T	ENST00000370014.3	+	9	1359	c.740C>T	c.(739-741)tCt>tTt	p.S247F	SENP6_ENST00000447266.2_Missense_Mutation_p.S247F|SENP6_ENST00000327284.8_Missense_Mutation_p.S240F|SENP6_ENST00000370010.2_Missense_Mutation_p.S240F	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	247					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				TTGAATGAGTCTACTGGACCA	0.358000													26	43					0	0	1	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705512	41705512	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:41705512G>A	ENST00000379485.1	-	1	1370	c.1136C>T	c.(1135-1137)aCt>aTt	p.T379I	KBTBD6_ENST00000499385.2_Missense_Mutation_p.T313I	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	379							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		GACAGTCCTAGTGTGAGCCAG	0.512000													70	38					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43953477	43953477	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:43953477G>C	ENST00000282406.4	+	17	2718	c.2608G>C	c.(2608-2610)Gat>Cat	p.D870H		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	870	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTGTGATTCAGATGAAGATTA	0.398000													16	28					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132159853	132159853	+	Silent	SNP	G	G	A	rs148747378	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:132159853G>A	ENST00000378679.3	-	7	2304	c.1500C>T	c.(1498-1500)ctC>ctT	p.L500L	SHROOM1_ENST00000378676.1_Silent_p.L431L|SHROOM1_ENST00000319854.3_Silent_p.L500L	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	500					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGACAGGTTTGAGGAGGTCAC	0.567000													30	55					0	0	1	0	0
NFIB	4781	broad.mit.edu	37	9	14146736	14146736	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:14146736G>C	ENST00000380959.3	-	6	1350	c.877C>G	c.(877-879)Cca>Gca	p.P293A	NFIB_ENST00000397581.2_Missense_Mutation_p.P293A|NFIB_ENST00000397575.3_Missense_Mutation_p.P293A|NFIB_ENST00000380924.1_Missense_Mutation_p.P41A|NFIB_ENST00000543693.1_Missense_Mutation_p.P41A|NFIB_ENST00000397579.2_Missense_Mutation_p.P293A|NFIB_ENST00000380953.1_Missense_Mutation_p.P293A|NFIB_ENST00000380934.4_Missense_Mutation_p.P319A	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	293					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GGTGAACTTGGAGAGGGGTAA	0.398000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								33	71					0	0	1	0	0
DBF4	10926	broad.mit.edu	37	7	87536595	87536595	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:87536595C>G	ENST00000265728.1	+	12	1646	c.1142C>G	c.(1141-1143)tCt>tGt	p.S381C		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	381					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding	p.S381Y(1)		endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				CAACATATTTCTCAGAAAGAT	0.373000													33	133					0	0	1	0	0
TIMM21	29090	broad.mit.edu	37	18	71822567	71822567	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:71822567G>C	ENST00000580087.1	+	3	677	c.391G>C	c.(391-393)Gaa>Caa	p.E131Q	TIMM21_ENST00000169551.6_Missense_Mutation_p.E131Q			Q9BVV7	TI21L_HUMAN	translocase of inner mitochondrial membrane 21 homolog (yeast)	131					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane											GATTTTCAAAGAACTTTTTTC	0.368000													32	42					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69882049	69882049	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:69882049G>A	ENST00000358913.5	+	2	1342	c.854G>A	c.(853-855)cGa>cAa	p.R285Q	MYPN_ENST00000540630.1_Missense_Mutation_p.R285Q|MYPN_ENST00000354393.2_Intron|MYPN_ENST00000373675.3_Missense_Mutation_p.R285Q	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	285	Ig-like 1.|Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GAAGGAACTCGAGTACAGTTG	0.468000													22	33					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123964020	123964020	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:123964020G>A	ENST00000314393.4	+	3	1105	c.270G>A	c.(268-270)ctG>ctA	p.L90L		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	90						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGCAAAACCTGAACGAGTTCA	0.468000													38	60					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102504909	102504909	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:102504909C>T	ENST00000360184.4	+	58	11185	c.11021C>T	c.(11020-11022)tCg>tTg	p.S3674L	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3674	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTGTCGCCATCGTTTGTCATC	0.542000													19	42					0	0	1	0	0
POLR3E	55718	broad.mit.edu	37	16	22337527	22337527	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:22337527C>G	ENST00000299853.5	+	18	1961	c.1794C>G	c.(1792-1794)ctC>ctG	p.L598L	POLR3E_ENST00000359210.4_Silent_p.L598L|POLR3E_ENST00000564209.1_Silent_p.L598L|POLR3E_ENST00000418581.2_Silent_p.L562L	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	598					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		GCCACACACTCTTCAGCGGCA	0.617000													18	28					0	0	1	0	0
STT3B	201595	broad.mit.edu	37	3	31574504	31574504	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:31574504C>A	ENST00000295770.2	+	1	223	c.14C>A	c.(13-15)tCg>tAg	p.S5*	STT3B_ENST00000453168.1_3'UTR	NM_178862.1	NP_849193.1	Q8TCJ2	STT3B_HUMAN	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	5					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			autonomic_ganglia(1)|biliary_tract(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	19						GCGGAGCCCTCGGCCCCGGAG	0.746000													11	23					6.40141e-05	6.46479e-05	1	1	0
ZNF57	126295	broad.mit.edu	37	19	2917917	2917917	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:2917917C>T	ENST00000306908.5	+	4	1446	c.1298C>T	c.(1297-1299)tCa>tTa	p.S433L	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Missense_Mutation_p.S401L	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTTGGTCCTCAACGTTTAGA	0.453000													25	66					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776787	38776787	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:38776787G>A	ENST00000308973.4	-	4	1030	c.425C>T	c.(424-426)tCa>tTa	p.S142L	TLR10_ENST00000508334.1_Missense_Mutation_p.S142L|TLR10_ENST00000361424.2_Missense_Mutation_p.S142L|TLR10_ENST00000506111.1_Missense_Mutation_p.S142L	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	142					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						TTCCAGGTGTGACATGTTGCC	0.388000													23	35					0	0	1	0	0
MAP2K5	5607	broad.mit.edu	37	15	67950939	67950939	+	Missense_Mutation	SNP	G	G	A	rs139491783		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:67950939G>A	ENST00000178640.5	+	12	1412	c.785G>A	c.(784-786)aGa>aAa	p.R262K	MAP2K5_ENST00000340972.4_Missense_Mutation_p.R72K|MAP2K5_ENST00000560591.1_3'UTR|MAP2K5_ENST00000395476.2_Missense_Mutation_p.R262K|MAP2K5_ENST00000354498.5_Missense_Mutation_p.R226K	NM_145160.2	NP_660143.1	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	262	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|skin(1)	16						GTCCTTGGAAGAATTGCAGTA	0.348000													23	94					0	0	1	0	0
AIG1	51390	broad.mit.edu	37	6	143486312	143486312	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:143486312C>T	ENST00000494282.2	+	3	416	c.391C>T	c.(391-393)Cac>Tac	p.H131Y	AIG1_ENST00000344492.5_Missense_Mutation_p.H79Y|AIG1_ENST00000367598.5_Missense_Mutation_p.H131Y|AIG1_ENST00000275235.4_Missense_Mutation_p.H131Y|AIG1_ENST00000357847.4_Missense_Mutation_p.H131Y			Q9NVV5	AIG1_HUMAN	androgen-induced 1	131						integral to membrane				endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)		GTGGCTGAATCACGGAATGGT	0.373000													38	68					0	0	1	0	0
ISY1-RAB43	100534599	broad.mit.edu	37	3	128813903	128813903	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:128813903G>A	ENST00000418265.1	-	12	1021	c.961C>T	c.(961-963)Cct>Tct	p.P321S	RAB43_ENST00000393308.1_Missense_Mutation_p.S105F|RAB43_ENST00000393304.1_Missense_Mutation_p.S105F|RAB43_ENST00000315150.5_Missense_Mutation_p.S105F|RAB43_ENST00000393305.1_Missense_Mutation_p.S105F|RAB43_ENST00000393307.1_Missense_Mutation_p.S105F|RAB43_ENST00000476465.1_Missense_Mutation_p.S105F	NM_001204890.1	NP_001191819.1	Q9ULR0	ISY1_HUMAN		0						catalytic step 2 spliceosome											CGACAGGAAGGAGCTCCTCTT	0.602000													28	50					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81060560	81060560	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:81060560C>T	ENST00000334512.5	+	17	2452	c.1880C>T	c.(1879-1881)tCg>tTg	p.S627L		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	627					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			TGGCCCGCCTCGGTGCAGGTC	0.647000													23	18					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107360888	107360888	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:107360888A>C	ENST00000374779.2	-	1	900	c.807T>G	c.(805-807)aaT>aaG	p.N269K		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						AGTCATCTGAATTAAGTGTCT	0.423000													29	62					0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130149473	130149473	+	Splice_Site	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:130149473C>T	ENST00000373387.4	+	25	2742	c.2390C>T	c.(2389-2391)tCg>tTg	p.S797L	GARNL3_ENST00000314904.5_Intron|GARNL3_ENST00000435213.2_Splice_Site_p.S775L|GARNL3_ENST00000496711.1_3'UTR	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	797	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						CCTTTCTAGTCGGATATATAC	0.572000													49	120					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161134932	161134932	+	Splice_Site	SNP	C	C	T	rs36113679		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161134932C>T	ENST00000368002.3	+	13	1983	c.1606C>T	c.(1606-1608)Cgt>Tgt	p.R536C	USP21_ENST00000368001.1_Splice_Site_p.R522C|USP21_ENST00000493054.1_3'UTR|USP21_ENST00000289865.8_Splice_Site_p.R536C	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	536					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.R536C(1)		breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAATGACTCTCGGTGAGAATA	0.562000													7	25					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40565108	40565108	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:40565108G>A	ENST00000455577.2	+	7	2310	c.1398G>A	c.(1396-1398)gaG>gaA	p.E466E	PAK6_ENST00000560346.1_Silent_p.E466E|PAK6_ENST00000453867.1_Silent_p.E466E|PAK6_ENST00000441369.1_Silent_p.E466E|PAK6_ENST00000542403.2_Silent_p.E466E|PAK6_ENST00000260404.4_Silent_p.E466E|RP11-133K1.2_ENST00000558658.1_3'UTR	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	466	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		ACGTGGTGGAGATGTACAAGA	0.632000													59	63					0	0	1	0	0
ARRDC3	57561	broad.mit.edu	37	5	90674580	90674580	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:90674580G>A	ENST00000265138.3	-	2	559	c.293C>T	c.(292-294)tCc>tTc	p.S98F	ARRDC3_ENST00000503192.1_5'UTR	NM_020801.2	NP_065852.1	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	98					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		GCCTTCTTCGGAATTATCATC	0.323000													12	16					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62984949	62984949	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:62984949C>G	ENST00000403374.2	-	5	472	c.169G>C	c.(169-171)Gag>Cag	p.E57Q	SLC22A10_ENST00000525620.1_Intron|SLC22A25_ENST00000306494.6_Missense_Mutation_p.E223Q|SLC22A10_ENST00000535888.1_Intron			Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	223					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GTTATCCACTCTACAACTGAA	0.403000													17	24					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2742833	2742833	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:2742833C>T	ENST00000406454.3	+	30	3867	c.3867C>T	c.(3865-3867)ctC>ctT	p.L1289L	CACNA1C_ENST00000399617.1_Silent_p.L1289L|CACNA1C_ENST00000344100.3_Intron|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000399597.1_Silent_p.L1289L|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000399638.1_Silent_p.L1289L|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000335762.5_Intron|CACNA1C_ENST00000399644.1_Silent_p.L1289L|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000399629.1_Silent_p.L1289L|CACNA1C_ENST00000399606.1_Intron|CACNA1C_ENST00000347598.4_Silent_p.L1309L|CACNA1C_ENST00000399603.1_Silent_p.L1289L|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000402845.3_Silent_p.L1289L|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000399655.1_Intron			Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1309					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTGACTTCCTCATCGTAATTG	0.453000													26	69					0	0	1	0	0
OMA1	115209	broad.mit.edu	37	1	59004653	59004653	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:59004653G>A	ENST00000371226.3	-	2	427	c.314C>T	c.(313-315)tCa>tTa	p.S105L	DAB1_ENST00000485760.1_Intron|OMA1_ENST00000467063.1_Intron|OMA1_ENST00000358603.2_Missense_Mutation_p.S105L	NM_145243.3	NP_660286.1	Q96E52	OMA1_HUMAN	OMA1 zinc metallopeptidase	105					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			NS(1)|breast(1)|large_intestine(6)|liver(2)|lung(6)|prostate(1)|skin(1)	18	all_cancers(7;6.54e-05)					CAGCTGTCTTGAAAAAGCATC	0.388000													36	47					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	16005027	16005027	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:16005027A>C	ENST00000268712.3	-	20	2484	c.2227T>G	c.(2227-2229)Tct>Gct	p.S743A	NCOR1_ENST00000395851.1_Missense_Mutation_p.S759A|NCOR1_ENST00000395848.1_Missense_Mutation_p.S650A	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	743					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TTTCCTCGAGAAGTAGCATTT	0.488000													6	50					0	0	1	0	0
ALKBH1	8846	broad.mit.edu	37	14	78174278	78174278	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:78174278G>A	ENST00000216489.3	-	1	85	c.70C>T	c.(70-72)Cgg>Tgg	p.R24W		NM_006020.2	NP_006011.2	Q13686	ALKB1_HUMAN	alkB, alkylation repair homolog 1 (E. coli)	24					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		AAAAGTTTCCGAAAGGCGTCC	0.667000													31	74					0	0	1	0	0
RANBP1	5902	broad.mit.edu	37	22	20106566	20106566	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:20106566G>T	ENST00000402752.1	+	2	272	c.46G>T	c.(46-48)Gag>Tag	p.E16*	RANBP1_ENST00000467920.1_3'UTR|RANBP1_ENST00000430524.1_5'UTR|RANBP1_ENST00000331821.3_Nonsense_Mutation_p.E16*	NM_001278640.1	NP_001265569.1	P43487	RANG_HUMAN	RAN binding protein 1	16			E -> D (in a breast cancer sample; somatic mutation).		intracellular transport|signal transduction|viral reproduction	nuclear envelope	GDP-dissociation inhibitor activity|GTPase activator activity|Ran GTPase binding			breast(1)|large_intestine(1)|lung(1)|ovary(1)	4	Colorectal(54;0.0993)					TACTTCCACTGAGAATACAGA	0.463000													22	43					3.8784e-16	4.01622e-16	1	1	0
FAM111A	63901	broad.mit.edu	37	11	58919502	58919502	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:58919502C>T	ENST00000528737.1	+	5	3179	c.361C>T	c.(361-363)Cac>Tac	p.H121Y	FAM111A_ENST00000531147.1_Missense_Mutation_p.H121Y|FAM111A_ENST00000420244.1_Missense_Mutation_p.H121Y|FAM111A_ENST00000533703.1_Missense_Mutation_p.H121Y|FAM111A_ENST00000361723.3_Missense_Mutation_p.H121Y			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	121					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				GATAGAAACTCACCAAGGCCA	0.443000													16	41					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75809629	75809629	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:75809629G>A	ENST00000306726.2	-	5	1011	c.499C>T	c.(499-501)Ctt>Ttt	p.L167F		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	167	CRAL-TRIO.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTCTTGCCAAGATCCAGCTCA	0.388000													15	27					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559534	46559534	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:46559534G>A	ENST00000242848.4	-	10	1966	c.1618C>T	c.(1618-1620)Cgt>Tgt	p.R540C	ZC3H13_ENST00000282007.3_Missense_Mutation_p.R540C			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	540	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		ATTTCCGTACGAGAACTTTCT	0.458000													41	40					0	0	1	0	0
FAM98C	147965	broad.mit.edu	37	19	38895578	38895578	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:38895578G>A	ENST00000252530.5	+	4	399	c.380G>A	c.(379-381)cGc>cAc	p.R127H	FAM98C_ENST00000585954.1_3'UTR|FAM98C_ENST00000343358.7_Missense_Mutation_p.R127H|FAM98C_ENST00000588262.1_Intron	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	127										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAAGCCACCCGCCTCCTGTGC	0.577000													126	312					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639059	6639059	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:6639059C>T	ENST00000333172.6	+	6	2134	c.1941C>T	c.(1939-1941)tcC>tcT	p.S647S	TAS1R1_ENST00000328191.4_3'UTR|TAS1R1_ENST00000351136.3_Silent_p.S393S	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	647					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TCTTCCTGTCCTGCCTGACAG	0.542000													25	75					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744270	98744270	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:98744270C>T	ENST00000286067.2	+	1	3230	c.3123C>T	c.(3121-3123)atC>atT	p.I1041I		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	1041										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GCGTATGCATCAACCCTCTGA	0.498000													44	46					0	0	1	0	0
CRYBA4	1413	broad.mit.edu	37	22	27021530	27021530	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:27021530G>A	ENST00000354760.3	+	4	279	c.244G>A	c.(244-246)Ggc>Agc	p.G82S	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	82	Beta/gamma crystallin 'Greek key' 2.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens			large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						TGCCTGGGGCGGCAACACGGC	0.637000													29	182					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70704766	70704766	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:70704766C>T	ENST00000229195.3	+	3	719	c.140C>T	c.(139-141)tCt>tTt	p.S47F	CNOT2_ENST00000418359.3_Missense_Mutation_p.S47F	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	47					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			TACAGCCAGTCTTCTATGTTT	0.388000													16	45					0	0	1	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144295145	144295145	+	Translation_Start_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:144295145G>A	ENST00000330824.2	+	1	78	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	1					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CCGGCGAGATGAAGGCGCTCG	0.662000													9	12					0	0	1	0	0
HARS2	23438	broad.mit.edu	37	5	140076763	140076763	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:140076763C>T	ENST00000230771.3	+	10	1192	c.969C>T	c.(967-969)ctC>ctT	p.L323L	HARS2_ENST00000435019.2_Silent_p.L283L|HARS2_ENST00000437649.2_Silent_p.L249L|HARS2_ENST00000508522.1_Silent_p.L298L|HARS2_ENST00000432671.2_Silent_p.L209L|HARS2_ENST00000448069.2_Silent_p.L151L	NM_012208.2	NP_036340.1	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2, mitochondrial	323					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(3)|large_intestine(5)|lung(10)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTTGACCTCAGCCTGGCTC	0.557000													57	79					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120580708	120580708	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:120580708G>A	ENST00000300648.6	-	43	5545	c.5533C>T	c.(5533-5535)Cac>Tac	p.H1845Y		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1845					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTGAGATGTGAAACAGGAGA	0.532000													39	80					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870545	51870545	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:51870545C>T	ENST00000371497.5	+	2	1435	c.548C>T	c.(547-549)tCt>tTt	p.S183F	TSHZ2_ENST00000603338.2_Missense_Mutation_p.S180F|TSHZ2_ENST00000329613.6_Missense_Mutation_p.S180F	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	183					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AACTTGCCTTCTCGGTCCGTC	0.552000													41	57					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30750002	30750002	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:30750002C>T	ENST00000262518.4	+	34	9026	c.8641C>T	c.(8641-8643)Ccc>Tcc	p.P2881S	SRCAP_ENST00000395059.2_Missense_Mutation_p.P2819S|SRCAP_ENST00000344771.4_Missense_Mutation_p.P2723S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2881	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GGATGAGGCACCCTCATCCAC	0.582000													28	36					0	0	1	0	0
PCNP	57092	broad.mit.edu	37	3	101311591	101311591	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:101311591C>T	ENST00000265260.3	+	5	652	c.531C>T	c.(529-531)gaC>gaT	p.D177D	PCNP_ENST00000296024.5_3'UTR|PCNP_ENST00000486406.1_3'UTR|PCNP_ENST00000469941.1_Silent_p.D54D	NM_020357.1	NP_065090.1	Q8WW12	PCNP_HUMAN	PEST proteolytic signal containing nuclear protein	177					cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding			large_intestine(1)|lung(1)	2						ATGACCAAGACAATTAAATGA	0.383000													23	40					0	0	1	0	0
MRPL10	124995	broad.mit.edu	37	17	45904544	45904544	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:45904544G>A	ENST00000290208.7	-	3	731	c.279C>T	c.(277-279)cgC>cgT	p.R93R	MRPL10_ENST00000414011.1_Silent_p.R93R|MRPL10_ENST00000351111.2_Silent_p.R83R			Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10	83					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			endometrium(3)|large_intestine(1)|lung(3)|ovary(1)	8						CTATCTCCCGGCGGAGAAGCC	0.542000													35	53					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8919253	8919253	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:8919253G>A	ENST00000256707.3	-	19	2568	c.2387C>T	c.(2386-2388)tCa>tTa	p.S796L	KIDINS220_ENST00000427284.1_Missense_Mutation_p.S796L|KIDINS220_ENST00000418530.1_Missense_Mutation_p.S754L|KIDINS220_ENST00000319688.5_Missense_Mutation_p.S797L|KIDINS220_ENST00000473731.1_Missense_Mutation_p.S796L	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	796	KAP NTPase.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CGGGCCTTTTGAAAACAGAAC	0.363000													67	69					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7401070	7401070	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:7401070C>T	ENST00000322644.6	+	7	1482	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	POLR2A_ENST00000572844.1_Silent_p.F361F	NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	361					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GAGTGGACTTCTCGGCCCGTA	0.602000													50	42					0	0	1	0	0
TNIP2	79155	broad.mit.edu	37	4	2746179	2746179	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:2746179G>C	ENST00000510267.1	-	5	1067	c.640C>G	c.(640-642)Caa>Gaa	p.Q214E	TNIP2_ENST00000505186.1_5'UTR|TNIP2_ENST00000315423.7_Missense_Mutation_p.Q321E|TNIP2_ENST00000503235.1_Missense_Mutation_p.Q238E	NM_001161527.1	NP_001154999.1	Q8NFZ5	TNIP2_HUMAN	TNFAIP3 interacting protein 2	321						cytosol	protein binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(6)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ATCCTACTTTGAGCCCGTTCC	0.507000													40	69					0	0	1	0	0
TMEM56	148534	broad.mit.edu	37	1	95657358	95657358	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:95657358C>G	ENST00000370203.4	+	7	1017	c.726C>G	c.(724-726)atC>atG	p.I242M	RP11-57H12.3_ENST00000419846.1_RNA|RP11-57H12.3_ENST00000421762.1_RNA|RP11-57H12.6_ENST00000604534.1_Intron	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	242	TLC.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		AAGGTTGCATCAAAGTCATCT	0.358000													11	45					0	0	1	0	0
CPSF4	10898	broad.mit.edu	37	7	99051739	99051739	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99051739G>A	ENST00000436336.2	+	7	807	c.646G>A	c.(646-648)Gag>Aag	p.E216K	PTCD1_ENST00000555673.1_Intron|CPSF4_ENST00000292476.5_Missense_Mutation_p.E241K|ATP5J2-PTCD1_ENST00000437572.1_Intron|CPSF4_ENST00000441580.1_Missense_Mutation_p.E163K|ATP5J2_ENST00000466753.1_Intron|CPSF4_ENST00000451876.1_Missense_Mutation_p.E183K|ATP5J2-PTCD1_ENST00000413834.1_Intron	NM_001081559.1|NM_006693.2	NP_001075028.1|NP_006684.1	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4, 30kDa	241					modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(5)	14	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CCGGCCACTGGAGCAGGTCAC	0.612000													12	88					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61537196	61537196	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:61537196G>A	ENST00000370371.4	-	6	1986	c.1631C>T	c.(1630-1632)tCt>tTt	p.S544F	DIDO1_ENST00000395343.1_Intron|DIDO1_ENST00000395340.1_Intron|DIDO1_ENST00000370366.1_Intron|DIDO1_ENST00000266071.5_Intron|DIDO1_ENST00000266070.4_Intron|DIDO1_ENST00000354665.4_Missense_Mutation_p.S544F|DIDO1_ENST00000395335.2_Intron|DIDO1_ENST00000370368.1_Missense_Mutation_p.S544F	NM_022105.4	NP_071388.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	0			M -> T (in dbSNP:rs1883848).		apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TATCCAGAAAGAACGGGAGGG	0.542000													70	102					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19106033	19106033	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19106033G>A	ENST00000601879.1	-	9	3345	c.3048C>T	c.(3046-3048)ttC>ttT	p.F1016F	SUGP2_ENST00000452918.2_Silent_p.F1016F|SUGP2_ENST00000337018.6_Silent_p.F1016F|SUGP2_ENST00000600377.1_Silent_p.F1030F|SUGP2_ENST00000456085.2_Silent_p.F785F			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	1016	G-patch.				mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GCAGCATCTGGAAGCCCAGGT	0.617000													15	30					0	0	1	0	0
PHB2	11331	broad.mit.edu	37	12	7076865	7076865	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:7076865C>T	ENST00000535923.1	-	6	966	c.685G>A	c.(685-687)Gag>Aag	p.E229K	PHB2_ENST00000542912.1_Missense_Mutation_p.E229K|PHB2_ENST00000440277.1_Intron|PHB2_ENST00000546111.1_Intron|PHB2_ENST00000399433.2_Missense_Mutation_p.E229K	NM_001144831.1	NP_001138303.1	Q99623	PHB2_HUMAN	prohibitin 2	229					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						GCCTCACCCTCGGCCTGCACA	0.592000													79	129					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37174926	37174926	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:37174926C>T	ENST00000262879.6	+	19	3039	c.2755C>T	c.(2755-2757)Cct>Tct	p.P919S	RALGAPB_ENST00000397038.1_Missense_Mutation_p.P697S|RALGAPB_ENST00000397040.1_Missense_Mutation_p.P919S|RALGAPB_ENST00000397042.3_Missense_Mutation_p.P915S			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	919					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						ACCTAGTGGTCCTGCCTCTCC	0.413000													40	61					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742593	10742593	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10742593G>A	ENST00000586078.1	+	9	785	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	SLC44A2_ENST00000335757.5_Missense_Mutation_p.E226K|SLC44A2_ENST00000407327.4_Missense_Mutation_p.E224K	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	226					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GCGCATATTTGAAGATTACAC	0.577000													28	66					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12318083	12318083	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:12318083C>T	ENST00000261349.4	-	8	1768	c.1692G>A	c.(1690-1692)gaG>gaA	p.E564E	LRP6_ENST00000543091.1_Silent_p.E564E	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	564	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TCACTTCCCTCTCTGCACTTC	0.423000													52	100					0	0	1	0	0
MFAP3	4238	broad.mit.edu	37	5	153429502	153429502	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:153429502C>T	ENST00000436816.1	+	2	439	c.220C>T	c.(220-222)Ctt>Ttt	p.L74F	MFAP3_ENST00000322602.5_Missense_Mutation_p.L74F|MFAP3_ENST00000439768.2_Intron	NM_001242336.1|NM_005927.4	NP_001229265.1|NP_005918.1	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3	74	Ig-like C2-type.					integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)	7	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		AATTGAGTGTCTTCTCACAGC	0.443000													27	54					0	0	1	0	0
ARF6	382	broad.mit.edu	37	14	50360571	50360571	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:50360571G>A	ENST00000298316.5	+	2	664	c.117G>A	c.(115-117)gtG>gtA	p.V39V		NM_001663.3	NP_001654.1	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	39					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding			endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)	4	all_epithelial(31;0.000822)|Breast(41;0.0117)					GCCAGTCGGTGACCACCATTC	0.547000													19	65					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103804699	103804699	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:103804699G>C	ENST00000216554.3	+	7	1151	c.475G>C	c.(475-477)Gaa>Caa	p.E159Q	EIF5_ENST00000392715.2_Missense_Mutation_p.E159Q|EIF5_ENST00000558506.1_Missense_Mutation_p.E159Q	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	159					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			gaaagaaaaagaaaagaaaaa	0.393000													18	41					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57763020	57763020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:57763020G>A	ENST00000269122.3	+	30	4952	c.4678G>A	c.(4678-4680)Gaa>Aaa	p.E1560K	CLTC_ENST00000393043.1_Missense_Mutation_p.E1560K|CLTC_ENST00000579456.1_Missense_Mutation_p.E497K	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1560	Heavy chain arm.|Proximal segment.|Trimerization (By similarity).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GTTTTTGCAGGAAGAAAAAAG	0.398000			T	"""ALK, TFE3"""	"""ALCL, renal """								5	134					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69257116	69257116	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:69257116G>A	ENST00000439696.2	-	2	452	c.151C>T	c.(151-153)Cgg>Tgg	p.R51W	ZFP36L1_ENST00000336440.3_Missense_Mutation_p.R51W|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	51					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GAGTGCCTCCGAGGGAAGCCC	0.627000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	30					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101912102	101912102	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:101912102G>A	ENST00000537097.1	+	6	4074	c.3261G>A	c.(3259-3261)agG>agA	p.R1087R	GPRASP1_ENST00000415986.1_Silent_p.R1087R|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Silent_p.R1087R|GPRASP1_ENST00000444152.1_Silent_p.R1087R	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	1087	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GCAAACCCAGGAACATGGTAC	0.488000													97	46					0	0	1	0	0
ZNF836	162962	broad.mit.edu	37	19	52659358	52659358	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:52659358G>A	ENST00000322146.8	-	5	2099	c.1578C>T	c.(1576-1578)taC>taT	p.Y526Y	ZNF836_ENST00000597252.1_Silent_p.Y526Y|CTC-471J1.8_ENST00000594362.1_RNA	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CACCGCATTGGTAACGTTTCT	0.378000													60	62					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41481832	41481832	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:41481832G>C	ENST00000359345.1	-	4	3746	c.1170C>G	c.(1168-1170)ctC>ctG	p.L390L	SLFNL1_ENST00000372611.1_Silent_p.L331L|SLFNL1_ENST00000397197.2_Silent_p.L342L|SLFNL1_ENST00000372613.2_Silent_p.L342L|SLFNL1_ENST00000439569.2_Silent_p.L390L|SLFNL1_ENST00000302946.8_Silent_p.L390L	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	390							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GCTGCTGCTGGAGCTGCTCCT	0.627000													4	131					0	0	1	0	0
MIER1	57708	broad.mit.edu	37	1	67442291	67442291	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:67442291C>T	ENST00000357692.2	+	13	1264	c.1007C>T	c.(1006-1008)tCa>tTa	p.S336L	MIER1_ENST00000401041.1_Missense_Mutation_p.S372L|MIER1_ENST00000401042.3_Missense_Mutation_p.S319L|MIER1_ENST00000371016.1_Missense_Mutation_p.S336L|MIER1_ENST00000355977.6_Missense_Mutation_p.S256L|MIER1_ENST00000371018.3_Missense_Mutation_p.S336L|MIER1_ENST00000371014.1_Missense_Mutation_p.S372L|MIER1_ENST00000355356.3_Missense_Mutation_p.S319L	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	343	SANT.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						CGAACAAGGTCAGTTGGTGAA	0.313000													11	38					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145621950	145621950	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:145621950G>A	ENST00000349769.3	-	25	2783	c.2689C>T	c.(2689-2691)Cac>Tac	p.H897Y		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	897					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TTGATGTTGTGAGGGACCTGG	0.657000													56	113					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42180660	42180660	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:42180660C>G	ENST00000401548.3	+	26	3258	c.3218C>G	c.(3217-3219)tCt>tGt	p.S1073C	MEI1_ENST00000300398.4_Missense_Mutation_p.S81C|MEI1_ENST00000400107.1_Missense_Mutation_p.S406C|MEI1_ENST00000476893.1_3'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	1073							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						AGCTTTTCCTCTGCCCTGGTA	0.602000													13	34					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37169002	37169002	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:37169002G>T	ENST00000274258.7	-	34	7351	c.3764C>A	c.(3763-3765)aCc>aAc	p.T1255N	C5orf42_ENST00000508244.1_Missense_Mutation_p.T2375N|C5orf42_ENST00000425232.2_Missense_Mutation_p.T2375N			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2375										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGCTCTTGAGGTTGATGGAAA	0.408000													16	121					2.32078e-09	2.37568e-09	1	1	0
OR12D3	81797	broad.mit.edu	37	6	29342573	29342573	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:29342573C>G	ENST00000396806.3	-	1	495	c.492G>C	c.(490-492)ctG>ctC	p.L164L	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						CACAAAAACTCAGGTGTGCAG	0.468000													21	46					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47597284	47597284	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:47597284G>A	ENST00000253048.5	-	4	472	c.435C>T	c.(433-435)ttC>ttT	p.F145F	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	145							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CACTGGGGCTGAAATCCGAGT	0.577000													40	95					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12633230	12633230	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:12633230G>A	ENST00000251849.4	-	11	1609	c.1170C>T	c.(1168-1170)ttC>ttT	p.F390F	RAF1_ENST00000542177.1_Silent_p.F309F|RAF1_ENST00000442415.2_Silent_p.F410F|RAF1_ENST00000534997.1_Silent_p.F175F	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	390	Protein kinase.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	CCTCATTCCTGAAGGCCTGGA	0.512000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				25	42					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144808914	144808914	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:144808914G>A	ENST00000388913.3	-	5	2842	c.2717C>T	c.(2716-2718)tCa>tTa	p.S906L		NM_198488.3	NP_940890	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	906					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGGGTAGGCTGAGGTGGGGCT	0.677000													14	26					0	0	1	0	0
ZNF524	147807	broad.mit.edu	37	19	56113777	56113777	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:56113777C>T	ENST00000591046.1	+	1	533	c.299C>T	c.(298-300)tCa>tTa	p.S100L	ZNF524_ENST00000301073.3_Missense_Mutation_p.S100L			Q96C55	ZN524_HUMAN	zinc finger protein 524	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		TCTGAAGGTTCAGCGGCTGGG	0.672000													10	6					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450518	55450518	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:55450518G>A	ENST00000588756.1	-	6	2155	c.1669C>T	c.(1669-1671)Ctt>Ttt	p.L557F	NLRP7_ENST00000448121.2_Missense_Mutation_p.L557F|NLRP7_ENST00000328092.5_Missense_Mutation_p.L557F|NLRP7_ENST00000590030.1_Missense_Mutation_p.L557F|NLRP7_ENST00000446217.1_Missense_Mutation_p.L585F|NLRP7_ENST00000592784.1_Missense_Mutation_p.L557F|NLRP7_ENST00000340844.2_Missense_Mutation_p.L557F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	557							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTTGCATGAAGATGTGCTTTG	0.562000													31	80					0	0	1	0	0
RPF1	80135	broad.mit.edu	37	1	84961961	84961961	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:84961961C>T	ENST00000370654.5	+	8	931	c.916C>T	c.(916-918)Cag>Tag	p.Q306*		NM_025065.6	NP_079341.2	Q9H9Y2	RPF1_HUMAN	ribosome production factor 1 homolog (S. cerevisiae)	306	Brix.|RNA-binding (By similarity).				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(2)|prostate(1)	14						AGTGGGAATTCAGGAACTTGG	0.348000													8	23					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4012970	4012970	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4012970G>C	ENST00000381638.2	-	6	1378	c.1254C>G	c.(1252-1254)gtC>gtG	p.V418V	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	418							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GCACTGTCTGGACAAAGGCGG	0.493000													29	19					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62604697	62604697	+	Missense_Mutation	SNP	C	C	T	rs144346146	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:62604697C>T	ENST00000281156.4	-	6	931	c.653G>A	c.(652-654)cGa>cAa	p.R218Q		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	218	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		GAGAACACCTCGTCCAGGTGG	0.592000													14	31					0	0	1	0	0
YIPF2	78992	broad.mit.edu	37	19	11034231	11034231	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:11034231C>T	ENST00000586748.1	-	8	946	c.774G>A	c.(772-774)gtG>gtA	p.V258V	YIPF2_ENST00000253031.2_Silent_p.V258V|YIPF2_ENST00000590329.1_Silent_p.V219V			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	258						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						GCACTGTGGCCACCAGCCTGG	0.692000													24	57					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202141606	202141606	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:202141606C>G	ENST00000358485.4	+	7	1090	c.894C>G	c.(892-894)atC>atG	p.I298M	CASP8_ENST00000392259.2_Missense_Mutation_p.Q218E|CASP8_ENST00000264275.5_Missense_Mutation_p.I256M|CASP8_ENST00000392258.3_Missense_Mutation_p.Q218E|CASP8_ENST00000432109.2_Missense_Mutation_p.I239M|CASP8_ENST00000264274.9_Intron|CASP8_ENST00000323492.7_Missense_Mutation_p.I224M|CASP8_ENST00000392266.3_Missense_Mutation_p.Q203E	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	239					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						GTCTGATCATCAACAATCACA	0.448000										HNSCC(4;0.00038)			17	22					0	0	1	0	0
SEMA4B	10509	broad.mit.edu	37	15	90760693	90760693	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:90760693C>T	ENST00000411539.2	+	2	440	c.180C>T	c.(178-180)ctC>ctT	p.L60L	SEMA4B_ENST00000332496.6_Silent_p.L60L|SEMA4B_ENST00000379122.3_Silent_p.L55L	NM_198925.2	NP_945119.1			sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B											NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)	12	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			GGCCATTCCTCAGATTCGAAG	0.562000													16	10					0	0	1	0	0
IP6K2	51447	broad.mit.edu	37	3	48732415	48732415	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:48732415G>A	ENST00000431721.2	-	3	712	c.475C>T	c.(475-477)Ctg>Ttg	p.L159L	IP6K2_ENST00000417896.1_Silent_p.L104L|IP6K2_ENST00000432678.2_Intron|IP6K2_ENST00000446860.1_Silent_p.L162L|IP6K2_ENST00000449610.1_Silent_p.L104L|IP6K2_ENST00000340879.4_Intron|IP6K2_ENST00000413298.1_Intron|IP6K2_ENST00000450045.1_Intron|IP6K2_ENST00000328631.5_Intron|IP6K2_ENST00000436134.1_Intron|IP6K2_ENST00000453202.1_Silent_p.L104L|IP6K2_ENST00000443964.1_Silent_p.L163L	NM_001190316.1	NP_001177245.1	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	0					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						gGAAAGCACAGAGTGGGAGGG	0.592000													7	10					0	0	1	0	0
PALM	5064	broad.mit.edu	37	19	726158	726158	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:726158C>T	ENST00000264560.7	+	2	220	c.26C>T	c.(25-27)aCg>aTg	p.T9M	PALM_ENST00000338448.5_Missense_Mutation_p.T9M	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	9					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		GCAGAGACCACGTCCCAGCAG	0.672000													44	92					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209153527	209153527	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:209153527C>T	ENST00000264380.4	+	7	1054	c.896C>T	c.(895-897)tCt>tTt	p.S299F	PIKFYVE_ENST00000308862.6_Missense_Mutation_p.S213F|PIKFYVE_ENST00000392202.3_Missense_Mutation_p.S202F|PIKFYVE_ENST00000407449.1_Missense_Mutation_p.S299F	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	299					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						GCTGGGAAATCTCCTGCTCGA	0.358000													28	16					0	0	1	0	0
RELA	5970	broad.mit.edu	37	11	65422353	65422353	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:65422353G>A	ENST00000406246.3	-	11	1413	c.1152C>T	c.(1150-1152)ccC>ccT	p.P384P	RELA_ENST00000308639.9_Silent_p.P381P|RELA_ENST00000525693.1_3'UTR	NM_001243984.1|NM_001243985.1|NM_021975.3	NP_001230913.1|NP_001230914.1|NP_068810.3	Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	384					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						gcaggacttggggaggggccg	0.652000													5	2					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15354140	15354140	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:15354140C>T	ENST00000263377.2	-	14	2961	c.2740G>A	c.(2740-2742)Gag>Aag	p.E914K		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	914					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TCTTCATCCTCCAGCAGCACT	0.677000			T	C15orf55	lethal midline carcinoma of young people								3	11					0	0	1	0	0
GNL2	29889	broad.mit.edu	37	1	38033324	38033324	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:38033324C>G	ENST00000373062.3	-	15	2091	c.1993G>C	c.(1993-1995)Gag>Cag	p.E665Q	GNL2_ENST00000462812.1_5'UTR	NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	665					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				TCCTGTTCCTCTTCCCTTTGT	0.393000													35	55					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160176585	160176585	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:160176585C>T	ENST00000358372.4	+	8	2890	c.1133C>T	c.(1132-1134)tCc>tTc	p.S378F	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	378					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		ACTGTGGGTTCCCGCCACGTT	0.413000													23	29					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75678257	75678257	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:75678257G>A	ENST00000319410.5	-	2	191	c.70C>T	c.(70-72)Cac>Tac	p.H24Y	KARS_ENST00000302445.3_Intron|KARS_ENST00000568378.1_Missense_Mutation_p.H24Y	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	0					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	AGTTCCCTGTGACCCCACTCT	0.517000													4	8					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75968128	75968128	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:75968128G>A	ENST00000308508.5	-	10	6824	c.6732C>T	c.(6730-6732)ttC>ttT	p.F2244F		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	2244					angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						TTCGGAGGTAGAAGAGCAGGG	0.597000													29	76					0	0	1	0	0
WDR24	84219	broad.mit.edu	37	16	734745	734745	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:734745C>T	ENST00000293883.4	-	9	3121	c.2362G>A	c.(2362-2364)Gag>Aag	p.E788K	WDR24_ENST00000248142.6_Missense_Mutation_p.E918K	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	918										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				CAGGAGTACTCGCAGAGGTGG	0.692000													3	12					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23855601	23855601	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:23855601C>G	ENST00000405093.3	-	33	4952	c.4882G>C	c.(4882-4884)Gag>Cag	p.E1628Q	MYH6_ENST00000356287.3_Missense_Mutation_p.E1628Q	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1628					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGCTGGATCTCCATCTCATTG	0.612000													31	95					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1251888	1251888	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:1251888C>T	ENST00000300952.2	+	4	887	c.372C>T	c.(370-372)ctC>ctT	p.L124L	MIDN_ENST00000591446.2_Silent_p.L124L	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	124						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGAGAGTCTCACGGAGACGC	0.642000													18	12					0	0	1	0	0
MOSPD2	158747	broad.mit.edu	37	X	14937913	14937913	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:14937913C>G	ENST00000380492.3	+	15	1627	c.1539C>G	c.(1537-1539)ttC>ttG	p.F513L	MOSPD2_ENST00000495110.1_3'UTR|MOSPD2_ENST00000482354.1_Intron	NM_001177475.1|NM_152581.3	NP_001170946.1|NP_689794.1	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	513						integral to membrane	structural molecule activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	Hepatocellular(33;0.183)					CCTCTTTCTTCTATTTATTGT	0.433000													65	30					0	0	1	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64695613	64695613	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:64695613C>T	ENST00000164133.2	+	5	1196	c.574C>T	c.(574-576)Caa>Taa	p.Q192*		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	192					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						ATATGTGGATCAAAAGTTTGT	0.562000													57	74					0	0	1	0	0
ARF5	381	broad.mit.edu	37	7	127229639	127229639	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:127229639G>A	ENST00000000233.5	+	3	403	c.249G>A	c.(247-249)caG>caA	p.Q83Q	GCC1_ENST00000497650.1_Intron	NM_001662.3	NP_001653.1	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	83					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			cervix(2)|kidney(1)|lung(10)|ovary(1)	14						ACTACTTCCAGAACACTCAGG	0.542000													36	35					0	0	1	0	0
GPR107	57720	broad.mit.edu	37	9	132854624	132854624	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:132854624C>G	ENST00000372406.1	+	9	1334	c.827C>G	c.(826-828)tCt>tGt	p.S276C	GPR107_ENST00000347136.6_Missense_Mutation_p.S276C|GPR107_ENST00000372410.3_Missense_Mutation_p.S276C	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	276						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TTCTTTCTTTCTGGGACCATC	0.403000													28	54					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41137013	41137013	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:41137013C>T	ENST00000344051.4	+	2	495	c.261C>T	c.(259-261)tgC>tgT	p.C87C	SPINT1_ENST00000431806.1_Silent_p.C87C|SPINT1_ENST00000562057.1_Silent_p.C87C			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	87	MANSC.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GCTGGGACTGCGTGCGCGCCT	0.682000													18	17					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934958	28934958	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:28934958G>A	ENST00000257192.4	+	15	3011	c.2799G>A	c.(2797-2799)atG>atA	p.M933I	DSG1_ENST00000462981.2_Missense_Mutation_p.M292I|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	933					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CTTCCGGCATGATAGGTAGTC	0.478000													92	194					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92224293	92224293	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:92224293C>T	ENST00000212355.4	-	4	726	c.261G>A	c.(259-261)ctG>ctA	p.L87L	TGFBR3_ENST00000468996.2_5'UTR|TGFBR3_ENST00000525962.1_Silent_p.L87L|TGFBR3_ENST00000370399.2_Silent_p.L87L	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	87					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		AGATGGGATTCAGGTGAAGTG	0.498000													11	67					0	0	1	0	0
COQ6	51004	broad.mit.edu	37	14	74425724	74425724	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:74425724G>A	ENST00000334571.2	+	6	703	c.663G>A	c.(661-663)caG>caA	p.Q221Q	COQ6_ENST00000238709.4_Silent_p.Q146Q|COQ6_ENST00000394026.4_Silent_p.Q196Q|COQ6_ENST00000554920.1_Intron|ENTPD5_ENST00000557325.1_3'UTR	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	221					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TTGGAATCCAGAATGTGAGCT	0.498000													24	53					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43317141	43317141	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:43317141G>A	ENST00000290650.4	-	25	2703	c.2625C>T	c.(2623-2625)ttC>ttT	p.F875F	UBR1_ENST00000382177.2_3'UTR	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	875					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		TCACTTTGCTGAAAGCAGGGC	0.453000													49	52					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200690	155200690	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:155200690G>C	ENST00000460012.1	-	23	3392	c.3035C>G	c.(3034-3036)tCa>tGa	p.S1012*	PLCH1_ENST00000414191.1_Nonsense_Mutation_p.S1012*|PLCH1_ENST00000334686.6_Nonsense_Mutation_p.S1012*|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000340059.7_Nonsense_Mutation_p.S1050*			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1050					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCTGTGACTGACATGTGGGC	0.483000													41	63					0	0	1	0	0
GPN2	54707	broad.mit.edu	37	1	27210662	27210662	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:27210662G>A	ENST00000374135.4	-	4	1049	c.849C>T	c.(847-849)ttC>ttT	p.F283F	GPN2_ENST00000374133.3_Silent_p.F104F	NM_018066.3	NP_060536.3	Q9H9Y4	GPN2_HUMAN	GPN-loop GTPase 2	283							GTP binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9						AAGAGAAATGGAAGTCGGCTC	0.537000													8	40					0	0	1	0	0
C7orf66	154907	broad.mit.edu	37	7	108524162	108524162	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:108524162C>T	ENST00000379007.2	-	2	304	c.250G>A	c.(250-252)Gag>Aag	p.E84K		NM_001024607.1	NP_001019778.1	A4D0T2	CG066_HUMAN	chromosome 7 open reading frame 66	84						integral to membrane				breast(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	15						ATGTATCCCTCATGAATTCTA	0.398000													14	59					0	0	1	0	0
CITED2	10370	broad.mit.edu	37	6	139695039	139695039	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:139695039C>T	ENST00000367651.2	-	2	258	c.43G>A	c.(43-45)Gac>Aac	p.D15N	CITED2_ENST00000537332.1_Missense_Mutation_p.D15N|CITED2_ENST00000536159.1_Missense_Mutation_p.D15N	NM_006079.4	NP_006070.2	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	15					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)|lung(4)	5	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		TTGGTGCCGTCGGGGAAGCGC	0.632000													14	32					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101833705	101833705	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:101833705C>T	ENST00000263468.8	+	6	2209	c.1939C>T	c.(1939-1941)Cat>Tat	p.H647Y	KIAA1377_ENST00000537689.1_Missense_Mutation_p.H448Y	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	647							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TGAAAACAGTCATTCACTGAA	0.348000													26	18					0	0	1	0	0
DAZAP1	26528	broad.mit.edu	37	19	1432626	1432626	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:1432626C>T	ENST00000336761.6	+	11	1190	c.985C>T	c.(985-987)Cag>Tag	p.Q329*	DAZAP1_ENST00000233078.4_Nonsense_Mutation_p.Q329*	NM_170711.1	NP_733829.1	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	329	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCCGTCTCAGGCTGCCCC	0.672000													66	114					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277669	186277669	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:186277669G>C	ENST00000445192.2	+	7	2863	c.2818G>C	c.(2818-2820)Gag>Cag	p.E940Q	PRG4_ENST00000367484.3_Missense_Mutation_p.E469Q|PRG4_ENST00000367485.4_Missense_Mutation_p.E847Q|PRG4_ENST00000367486.3_Missense_Mutation_p.E897Q|PRG4_ENST00000367483.4_Missense_Mutation_p.E899Q	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	940					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						GATGACAAAAGAGACAGCAAC	0.383000													33	120					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48229211	48229211	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:48229211C>T	ENST00000263277.3	+	4	896	c.645C>T	c.(643-645)cgC>cgT	p.R215R	EHD2_ENST00000538399.1_Silent_p.R79R|CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	215					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		ACAAGATCCGCGTGGTGCTCA	0.637000													18	22					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102605690	102605690	+	Silent	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:102605690G>T	ENST00000334701.7	-	1	333	c.52C>A	c.(52-54)Cgg>Agg	p.R18R	HSP90AA1_ENST00000558600.1_5'UTR	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	0					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TCCCTGTCCCGAAGGGAGGGC	0.721000													6	17					0.217242	0.217547	1	1	0
THEMIS2	9473	broad.mit.edu	37	1	28208599	28208599	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:28208599G>A	ENST00000373921.3	+	4	768	c.764G>A	c.(763-765)tGg>tAg	p.W255*	THEMIS2_ENST00000328928.7_Nonsense_Mutation_p.W255*|THEMIS2_ENST00000373925.1_Intron|THEMIS2_ENST00000373927.3_Intron	NM_001105556.1	NP_001099026.1			thymocyte selection associated family member 2																		GTCCTGGCCTGGGAAGGCCCT	0.632000													24	51					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66197802	66197802	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:66197802G>T	ENST00000273854.3	-	17	3497	c.2897C>A	c.(2896-2898)gCc>gAc	p.A966D	EPHA5_ENST00000354839.4_Missense_Mutation_p.A944D|EPHA5_ENST00000432638.2_Missense_Mutation_p.A803D|EPHA5_ENST00000511294.1_Missense_Mutation_p.A967D	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	966	SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGATCTGTAGGCCCCAGATCC	0.368000										TSP Lung(17;0.13)			4	36					0.00024832	0.000250424	1	1	0
PRSS8	5652	broad.mit.edu	37	16	31144247	31144247	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:31144247G>C	ENST00000317508.6	-	4	557	c.294C>G	c.(292-294)gtC>gtG	p.V98V	PRSS8_ENST00000568261.1_Intron	NM_002773.3	NP_002764.1	Q16651	PRSS8_HUMAN	protease, serine, 8	98	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	8						CCCCCAGCTTGACCTCATAGG	0.637000													67	86					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75556903	75556903	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:75556903C>T	ENST00000604729.1	+	17	3604	c.3307C>T	c.(3307-3309)Cca>Tca	p.P1103S	ZSWIM8_ENST00000398706.2_Missense_Mutation_p.P1103S|ZSWIM8_ENST00000603114.1_Missense_Mutation_p.P1065S|RP11-574K11.31_ENST00000603027.1_3'UTR|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.P1098S|ZSWIM8-AS1_ENST00000456638.2_RNA|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.P1098S					zinc finger, SWIM-type containing 8																		TGAGGGTCTTCCATCTGAGGC	0.582000													17	14					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096793	73096793	+	Silent	SNP	C	C	T	rs150399123		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:73096793C>T	ENST00000450736.2	+	4	1450	c.1035C>T	c.(1033-1035)atC>atT	p.I345I	SLC16A5_ENST00000538213.2_Silent_p.I385I|SLC16A5_ENST00000329783.4_Silent_p.I345I|SLC16A5_ENST00000580123.1_Silent_p.I345I			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	345					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TGAGTGGCATCGGCGCCCTCA	0.592000													39	81					0	0	1	0	0
C6orf222	389384	broad.mit.edu	37	6	36291965	36291965	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:36291965C>T	ENST00000437635.2	-	7	1348	c.1171G>A	c.(1171-1173)Gaa>Aaa	p.E391K		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	391								p.E391*(1)		breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						TGAATGAATTCTTCTGAAAAA	0.483000													18	25					0	0	1	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26123904	26123904	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:26123904C>T	ENST00000314332.5	-	1	234	c.229G>A	c.(229-231)Gag>Aag	p.E77K	HIST1H2BC_ENST00000396984.1_Missense_Mutation_p.E77K			P62807	H2B1C_HUMAN	histone cluster 1, H2bc	77					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						CGGGAAGCCTCGCCCGCGATG	0.587000													72	126					0	0	1	0	0
ACKR4	51554	broad.mit.edu	37	3	132319264	132319264	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:132319264C>T	ENST00000249887.2	+	2	119	c.23C>T	c.(22-24)tCa>tTa	p.S8L	ACAD11_ENST00000264990.6_Intron|ACAD11_ENST00000545291.1_Intron|ACAD11_ENST00000355458.3_Intron	NM_016557.2|NM_178445.2	NP_057641.1|NP_848540.1			atypical chemokine receptor 4																		CAGAACCAGTCAACAGATTAT	0.328000													9	16					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6515415	6515415	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:6515415G>A	ENST00000361413.3	-	8	1727	c.1369C>T	c.(1369-1371)Ctt>Ttt	p.L457F	KIAA0753_ENST00000542606.1_Missense_Mutation_p.L158F|KIAA0753_ENST00000572370.1_Missense_Mutation_p.L158F|KIAA0753_ENST00000589033.1_Intron	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	457						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		AATACATCAAGCTCACTCTGC	0.413000													74	35					0	0	1	0	0
PARVA	55742	broad.mit.edu	37	11	12518096	12518096	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:12518096C>T	ENST00000334956.8	+	5	955	c.612C>T	c.(610-612)atC>atT	p.I204I	PARVA_ENST00000550549.1_Silent_p.I164I|PARVA_ENST00000539723.1_Silent_p.I164I|PARVA_ENST00000538608.1_Silent_p.I111I	NM_018222.4	NP_060692.2	Q9NVD7	PARVA_HUMAN	parvin, alpha	164					cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)	11				Epithelial(150;0.00624)		TGGAGAAGATCAATGAAACCC	0.483000													3	22					0	0	1	0	0
BST1	683	broad.mit.edu	37	4	15706551	15706551	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:15706551G>T	ENST00000382346.3	+	2	246	c.197G>T	c.(196-198)aGa>aTa	p.R66I	BST1_ENST00000265016.4_Intron			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	63					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						AGGCAAATAAGAAACAGCAGA	0.383000													4	12					0.014758	0.0148203	1	1	0
ALOX15	246	broad.mit.edu	37	17	4536449	4536449	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4536449G>C	ENST00000570836.1	-	11	1506	c.1410C>G	c.(1408-1410)atC>atG	p.I470M	ALOX15_ENST00000574640.1_Missense_Mutation_p.I431M|ALOX15_ENST00000545513.1_Missense_Mutation_p.I492M|ALOX15_ENST00000293761.3_Missense_Mutation_p.I470M			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	470	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	ACCGATAGATGATTTCCCAGA	0.617000													39	20					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137501674	137501674	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:137501674G>A	ENST00000254900.5	-	11	1492	c.1121C>T	c.(1120-1122)tCa>tTa	p.S374L	BRD8_ENST00000230901.5_Missense_Mutation_p.S447L|BRD8_ENST00000402931.1_Missense_Mutation_p.S374L|BRD8_ENST00000455658.2_Missense_Mutation_p.S333L|BRD8_ENST00000411594.2_Missense_Mutation_p.S377L	NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	374					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGCTACCCCTGATCGAAAACA	0.463000													34	83					0	0	1	0	0
EDEM1	9695	broad.mit.edu	37	3	5229559	5229559	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:5229559C>A	ENST00000600805.1	-	1	423	c.424G>T	c.(424-426)Gag>Tag	p.E142*	EDEM1_ENST00000256497.4_Silent_p.L23L																							TATTGTGGCTCGTCTTCGGGC	0.667000													9	20					0.00448238	0.00451399	1	1	0
FEM1B	10116	broad.mit.edu	37	15	68582890	68582890	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:68582890G>C	ENST00000306917.4	+	2	1809	c.1194G>C	c.(1192-1194)ttG>ttC	p.L398F		NM_015322.4	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	398					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						TGATACATTTGAATGAAACTG	0.393000													28	54					0	0	1	0	0
GALM	130589	broad.mit.edu	37	2	38908553	38908553	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:38908553C>T	ENST00000272252.5	+	3	729	c.477C>T	c.(475-477)gtC>gtT	p.V159V	GALM_ENST00000410063.1_Intron	NM_138801.2	NP_620156.1	Q96C23	GALM_HUMAN	galactose mutarotase (aldose 1-epimerase)	159					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	14		all_hematologic(82;0.248)				AGCTCATAGTCAACTACAGAG	0.522000													70	147					0	0	1	0	0
RCE1	9986	broad.mit.edu	37	11	66612482	66612482	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:66612482C>T	ENST00000309657.3	+	5	638	c.594C>T	c.(592-594)ttC>ttT	p.F198F	RCE1_ENST00000525356.1_Silent_p.F75F|RCE1_ENST00000524506.1_Silent_p.F198F	NM_001032279.1|NM_005133.2	NP_001027450.1|NP_005124.1	Q9Y256	FACE2_HUMAN	Ras converting CAAX endopeptidase 1	198					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			breast(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CTGCTGTGTTCACCTGCCCGC	0.592000													18	56					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43779424	43779424	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:43779424G>A	ENST00000405006.4	-	18	3080	c.2729C>T	c.(2728-2730)tCt>tTt	p.S910F	THADA_ENST00000405975.2_Missense_Mutation_p.S910F|THADA_ENST00000330266.7_Missense_Mutation_p.S620F|THADA_ENST00000415080.2_Missense_Mutation_p.S620F|THADA_ENST00000402360.2_Missense_Mutation_p.S910F	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	910							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CTGAAGCAGAGAATTTTCAGC	0.383000													17	18					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99695482	99695482	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99695482G>C	ENST00000303887.5	-	8	1605	c.960C>G	c.(958-960)acC>acG	p.T320T	MCM7_ENST00000343023.6_Silent_p.T320T|MCM7_ENST00000354230.3_Silent_p.T144T	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	320					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GCTCCTCCCTGGTGAGCTCTC	0.512000													4	90					0	0	1	0	0
HP1BP3	50809	broad.mit.edu	37	1	21071503	21071503	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:21071503G>A	ENST00000375003.2	-	9	2493	c.993C>T	c.(991-993)gtC>gtT	p.V331V	HP1BP3_ENST00000312239.5_Silent_p.V483V			Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	483					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GGGCAGCTGAGACTTTAGGTG	0.557000													26	49					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49706754	49706754	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:49706754G>A	ENST00000303221.5	-	4	644	c.429C>T	c.(427-429)ttC>ttT	p.F143F	EMB_ENST00000508934.1_Silent_p.F89F|EMB_ENST00000506190.1_5'UTR|EMB_ENST00000514111.1_Silent_p.F93F	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	143	Ig-like V-type 1.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CCTCTCGAAAGAAACAAGAAT	0.289000													12	31					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35095512	35095512	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:35095512G>A	ENST00000378617.3	-	2	445	c.51C>T	c.(49-51)ttC>ttT	p.F17F	PIGO_ENST00000341666.3_Silent_p.F17F|PIGO_ENST00000361778.2_Silent_p.F17F|PIGO_ENST00000298004.5_Silent_p.F17F|PIGO_ENST00000492770.1_5'UTR	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	17					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGCCAGCGTAGAAGAGGAAGC	0.572000													15	21					0	0	1	0	0
SPEF1	25876	broad.mit.edu	37	20	3759867	3759867	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:3759867C>T	ENST00000379756.3	-	3	514	c.354G>A	c.(352-354)agG>agA	p.R118R	SPEF1_ENST00000463490.1_5'UTR	NM_015417.4	NP_056232.2	Q9Y4P9	SPEF1_HUMAN	sperm flagellar 1	118						cilium axoneme|cytoplasm|cytoskeleton				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						CGCCCTGCTTCCTGCGCCTCT	0.697000													3	5					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98641342	98641342	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:98641342G>A	ENST00000261574.5	+	7	625	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K	IPO5_ENST00000539640.1_Intron|IPO5_ENST00000490680.1_Missense_Mutation_p.E131K	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	131					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						CCAGTGGCCCGAAGGTTTGAA	0.378000													8	31					0	0	1	0	0
RPLP2	6181	broad.mit.edu	37	11	810264	810264	+	Silent	SNP	T	T	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:810264T>C	ENST00000321153.4	+	2	424	c.30T>C	c.(28-30)gcT>gcC	p.A10A	RPLP2_ENST00000530797.1_Silent_p.A10A|RPLP2_ENST00000532004.1_Intron	NM_001004.3	NP_000995.1	P05387	RLA2_HUMAN	ribosomal protein, large, P2	10					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			lung(1)	1		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCTGCTGGCTGCCCTAGGGG	0.692000													8	20					0	0	1	0	0
B4GALT3	8703	broad.mit.edu	37	1	161143460	161143460	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:161143460C>G	ENST00000319769.5	-	6	960	c.738G>C	c.(736-738)ctG>ctC	p.L246L	B4GALT3_ENST00000367998.1_Silent_p.L246L|PPOX_ENST00000495483.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000535223.1_Intron|B4GALT3_ENST00000470882.1_5'UTR	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	246					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	CATTCATCTTCAGGTACTGGT	0.562000													59	69					0	0	1	0	0
NSRP1	84081	broad.mit.edu	37	17	28511835	28511835	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:28511835G>C	ENST00000247026.5	+	7	883	c.820G>C	c.(820-822)Gag>Cag	p.E274Q	NSRP1_ENST00000540900.3_3'UTR	NM_001261467.1|NM_032141.3	NP_001248396.1|NP_115517.1	Q9H0G5	NSRP1_HUMAN	nuclear speckle splicing regulatory protein 1	274					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	14						AAAGGTCATAGAGACCCCTGA	0.483000													26	56					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339590	16339590	+	Silent	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:16339590G>T	ENST00000400202.1	-	3	1636	c.924C>A	c.(922-924)ggC>ggA	p.G308G	NRIP1_ENST00000400199.1_Silent_p.G308G|NRIP1_ENST00000318948.4_Silent_p.G308G			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	308	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CATCCTTCTGGCCATTTTCTT	0.428000													13	27					9.31168e-06	9.43055e-06	1	1	0
TSSC4	10078	broad.mit.edu	37	11	2424368	2424368	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:2424368G>A	ENST00000333256.6	+	3	948	c.505G>A	c.(505-507)Gat>Aat	p.D169N	TSSC4_ENST00000467308.1_3'UTR|TSSC4_ENST00000451491.2_Missense_Mutation_p.D169N|TSSC4_ENST00000380992.1_Missense_Mutation_p.D105N|TSSC4_ENST00000380996.5_Missense_Mutation_p.D105N			Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	169										endometrium(3)|large_intestine(1)|lung(4)	8		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCCTGGAAGATGTGACCGA	0.672000													15	20					0	0	1	0	0
UBA52	7311	broad.mit.edu	37	19	18684538	18684538	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:18684538C>T	ENST00000442744.2	+	3	228	c.170C>T	c.(169-171)tCa>tTa	p.S57L	UBA52_ENST00000597451.1_Missense_Mutation_p.S57L|UBA52_ENST00000599595.1_Missense_Mutation_p.S57L|UBA52_ENST00000599551.1_Missense_Mutation_p.S57L|UBA52_ENST00000596273.1_Missense_Mutation_p.S57L|CRLF1_ENST00000594325.1_Intron|UBA52_ENST00000595683.1_Missense_Mutation_p.S57L|UBA52_ENST00000598780.1_Missense_Mutation_p.S57L|UBA52_ENST00000595158.1_Missense_Mutation_p.S57L|UBA52_ENST00000596304.1_Missense_Mutation_p.S57L|UBA52_ENST00000430157.2_Missense_Mutation_p.S57L	NM_001033930.1	NP_001029102.1	P62987	RL40_HUMAN	ubiquitin A-52 residue ribosomal protein fusion product 1	57	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome			endometrium(1)|large_intestine(2)	3						CGCACTCTCTCAGACTACAAC	0.592000													31	43					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298847	107298847	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:107298847G>A	ENST00000374781.2	-	1	290	c.248C>T	c.(247-249)tCt>tTt	p.S83F		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						GTGAAAATGAGAATCAAAGAT	0.398000													30	54					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74605327	74605327	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:74605327G>T	ENST00000361874.3	-	2	396	c.79C>A	c.(79-81)Ctg>Atg	p.L27M	DCTN1_ENST00000409240.1_Missense_Mutation_p.L10M|DCTN1_ENST00000409567.3_Missense_Mutation_p.L27M|DCTN1_ENST00000409868.1_Missense_Mutation_p.L10M|DCTN1_ENST00000394003.3_Missense_Mutation_p.L27M	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	27					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						CCCACCCGCAGAGGCCGGGCG	0.587000													18	103					2.35188e-11	2.41618e-11	1	1	0
GPR37L1	9283	broad.mit.edu	37	1	202096876	202096876	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:202096876C>T	ENST00000367282.5	+	2	744	c.638C>T	c.(637-639)tCt>tTt	p.S213F		NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1							integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						CAGGTCTCCTCTCTGGGAGTC	0.582000													24	51					0	0	1	0	0
COPZ2	51226	broad.mit.edu	37	17	46111232	46111232	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:46111232C>G	ENST00000006101.4	-	4	258	c.259G>C	c.(259-261)Gag>Cag	p.E87Q	COPZ2_ENST00000584666.1_5'UTR	NM_016429.2	NP_057513.1	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat				lung(3)|upper_aerodigestive_tract(1)	4						CACTTACTCTCAGTCCGGCTG	0.483000													3	11					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4903131	4903131	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:4903131C>T	ENST00000396658.4	+	1	916	c.213C>T	c.(211-213)atC>atT	p.I71I	UBN1_ENST00000590769.1_Silent_p.I71I|UBN1_ENST00000262376.6_Silent_p.I71I|UBN1_ENST00000545171.1_Silent_p.I71I	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	71	Sufficient for interaction with HIRA.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						TGAAGAATATCCGAGGGAAGG	0.542000													21	60					0	0	1	0	0
ZNF394	84124	broad.mit.edu	37	7	99097547	99097547	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99097547G>A	ENST00000337673.6	-	1	373	c.170C>T	c.(169-171)tCg>tTg	p.S57L	ZNF394_ENST00000394177.3_Intron|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.S57L	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	57					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGGGTCCGGCGAAGCCGCGGG	0.632000													51	50					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10886554	10886554	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10886554C>T	ENST00000314646.5	+	4	725	c.561C>T	c.(559-561)ctC>ctT	p.L187L	DNM2_ENST00000591819.1_3'UTR|DNM2_ENST00000359692.6_Silent_p.L187L|DNM2_ENST00000389253.4_Silent_p.L187L|DNM2_ENST00000408974.4_Silent_p.L187L|DNM2_ENST00000585892.1_Silent_p.L187L|DNM2_ENST00000355667.6_Silent_p.L187L			P50570	DYN2_HUMAN	dynamin 2	187					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CCGACGCCCTCAAGCTGGCCA	0.597000			"""F, N, Splice, Mis, O"""		ETP ALL								34	61					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23926686	23926686	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:23926686G>A	ENST00000402377.3	-	4	1807	c.1666C>T	c.(1666-1668)Cat>Tat	p.H556Y	ZNF681_ENST00000395385.3_Missense_Mutation_p.H487Y	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	556					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H487Y(1)		central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TCTCCAGTATGAATTACCTTA	0.393000													22	51					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388027	56388027	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:56388027G>A	ENST00000355701.3	-	20	4415	c.3545C>T	c.(3544-3546)gCa>gTa	p.A1182V	BZRAP1_ENST00000343736.4_Missense_Mutation_p.A1182V|BZRAP1_ENST00000268893.6_Missense_Mutation_p.A1122V	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1182						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGAGGGAGCTGCGGGGCCAGG	0.672000													12	34					0	0	1	0	0
RPL24	6152	broad.mit.edu	37	3	101401690	101401690	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:101401690G>A	ENST00000469605.1	-	4	272	c.254C>T	c.(253-255)gCa>gTa	p.A85V	RPL24_ENST00000495401.1_Missense_Mutation_p.A85V|RPL24_ENST00000394077.3_Missense_Mutation_p.A85V			P83731	RL24_HUMAN	ribosomal protein L24	85					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			large_intestine(1)|lung(2)|urinary_tract(1)	4						AGCAAGAGATGCACCAGTAAT	0.443000													18	39					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116429065	116429065	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:116429065G>A	ENST00000281928.3	-	17	3900	c.3694C>T	c.(3694-3696)Caa>Taa	p.Q1232*		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1232					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TGTGTGTGTTGATTCTGGAGG	0.493000													27	88					0	0	1	0	0
ARFGAP2	84364	broad.mit.edu	37	11	47189594	47189594	+	Splice_Site	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:47189594C>G	ENST00000524782.1	-	12	1299	c.1071G>C	c.(1069-1071)aaG>aaC	p.K357N	ARFGAP2_ENST00000426335.2_Splice_Site_p.K221N|ARFGAP2_ENST00000395449.3_5'UTR|ARFGAP2_ENST00000419701.2_Splice_Site_p.K250N|ARFGAP2_ENST00000319543.6_Splice_Site_p.K88N	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	357	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TGTCCTTGTACCTAGGGAGAC	0.527000													11	75					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34929569	34929569	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:34929569G>C	ENST00000356577.4	+	4	6743	c.6268G>C	c.(6268-6270)Gaa>Caa	p.E2090Q	SON_ENST00000381679.4_Missense_Mutation_p.E2090Q|SON_ENST00000300278.4_Missense_Mutation_p.E2090Q|SON_ENST00000381692.2_Missense_Mutation_p.E118Q|SON_ENST00000290239.6_Missense_Mutation_p.E2090Q	NM_138927.1	NP_620305	P18583	SON_HUMAN	SON DNA binding protein	2090				E -> V (in Ref. 2; AAK07692 and 12; CAA45282).	anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						ACCTACTATAGAAGAGAAAGT	0.403000													19	20					0	0	1	0	0
TMEM202	338949	broad.mit.edu	37	15	72699440	72699440	+	Silent	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:72699440C>A	ENST00000341689.3	+	4	555	c.501C>A	c.(499-501)ctC>ctA	p.L167L	TMEM202_ENST00000567679.1_Intron	NM_001080462.1	NP_001073931.1	A6NGA9	TM202_HUMAN	transmembrane protein 202	167						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	18						CCTGCTTGCTCCTCTGCCTCA	0.532000													16	65					0.00400662	0.00403773	1	1	0
PRRC2A	7916	broad.mit.edu	37	6	31599767	31599767	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31599767C>T	ENST00000376033.2	+	16	3551	c.3317C>T	c.(3316-3318)tCa>tTa	p.S1106L	PRRC2A_ENST00000376007.4_Missense_Mutation_p.S1106L	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1106	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CAGCGGGGCTCAGAAACAGGC	0.642000													31	47					0	0	1	0	0
DBF4	10926	broad.mit.edu	37	7	87530136	87530136	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:87530136G>C	ENST00000265728.1	+	10	1371	c.867G>C	c.(865-867)gaG>gaC	p.E289D		NM_006716.3	NP_006707.1	Q9UBU7	DBF4A_HUMAN	DBF4 homolog (S. cerevisiae)	289					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|skin(3)	28	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				AGTTGAAAGAGAAGAAGAAAA	0.353000													22	100					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47033343	47033343	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:47033343G>A	ENST00000450053.3	+	9	1118	c.939G>A	c.(937-939)atG>atA	p.M313I	NBEAL2_ENST00000292309.5_Missense_Mutation_p.M313I|NBEAL2_ENST00000383740.2_De_novo_Start_InFrame	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	313							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCATCCCCATGATGCTGGCAT	0.567000													8	16					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38939412	38939412	+	Missense_Mutation	SNP	C	C	G	rs150428096		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:38939412C>G	ENST00000359357.3	+	81	12099	c.11845C>G	c.(11845-11847)Cga>Gga	p.R3949G	DNAH8_ENST00000449981.2_Missense_Mutation_p.R4166G|DNAH8_ENST00000441566.1_Missense_Mutation_p.R3913G					dynein, axonemal, heavy chain 8									p.R3949*(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGTACATGCTCGAAAGCTGAT	0.418000													19	45					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95482795	95482795	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:95482795G>A	ENST00000356884.6	-	4	916	c.849C>T	c.(847-849)ctC>ctT	p.L283L	BICD2_ENST00000375512.3_Silent_p.L283L	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	283					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CACTGAACTTGAGGCCATCCA	0.577000													39	72					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110148938	110148938	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:110148938C>G	ENST00000351050.3	-	5	768	c.582G>C	c.(580-582)ttG>ttC	p.L194F		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	194					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		ACCTGAAATTCAAGTCTTTGA	0.493000													16	86					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99123932	99123932	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99123932C>T	ENST00000394170.2	+	6	1520	c.1269C>T	c.(1267-1269)gtC>gtT	p.V423V	ZKSCAN5_ENST00000326775.5_Silent_p.V423V|ZKSCAN5_ENST00000451158.1_Silent_p.V423V	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	423					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ACCACAGTGTCCACAGCGGAG	0.562000													66	258					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140358794	140358794	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:140358794C>T	ENST00000406427.1	-	27	3490	c.3154G>A	c.(3154-3156)Gag>Aag	p.E1052K	PNPLA7_ENST00000371457.1_Missense_Mutation_p.E633K|PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000277531.4_Missense_Mutation_p.E1027K	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1027	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GGGTGCACCTCGATCTGCTGG	0.652000													67	142					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018245	1018245	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:1018245G>A	ENST00000398484.2	+	7	1445	c.865G>A	c.(865-867)Gag>Aag	p.E289K	FGFRL1_ENST00000264748.6_Missense_Mutation_p.E289K|FGFRL1_ENST00000504138.1_Missense_Mutation_p.E289K|FGFRL1_ENST00000510644.1_Missense_Mutation_p.E289K			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	289	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GTACGGCGCCGAGGGCCGCCA	0.657000													17	81					0	0	1	0	0
CXCR6	10663	broad.mit.edu	37	3	45988917	45988917	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:45988917C>A	ENST00000458629.1	+	1	2407	c.944C>A	c.(943-945)tCa>tAa	p.S315*	CXCR6_ENST00000457814.1_Nonsense_Mutation_p.S315*|FYCO1_ENST00000535325.1_Intron|CXCR6_ENST00000304552.4_Nonsense_Mutation_p.S315*|FYCO1_ENST00000438446.1_Intron|CXCR6_ENST00000438735.1_Nonsense_Mutation_p.S315*|FYCO1_ENST00000296137.2_Intron			O00574	CXCR6_HUMAN	chemokine (C-X-C motif) receptor 6	315					viral genome replication	integral to plasma membrane	coreceptor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|lung(1)|prostate(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CTTGGGGTCTCACATCAATGG	0.478000													37	49					2.19358e-23	2.28478e-23	1	1	0
ATG16L2	89849	broad.mit.edu	37	11	72537613	72537613	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:72537613G>T	ENST00000321297.5	+	12	1362	c.1224G>T	c.(1222-1224)aaG>aaT	p.K408N	ATG16L2_ENST00000534905.1_Intron	NM_033388.1	NP_203746.1	Q8NAA4	A16L2_HUMAN	autophagy related 16-like 2 (S. cerevisiae)	408					autophagy|protein transport	cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	14			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			AGCTCTGGAAGGTGGGGGAGG	0.592000													36	30					6.70999e-13	6.91332e-13	1	1	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631213	99631213	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:99631213C>T	ENST00000324306.6	+	6	1319	c.1085C>T	c.(1084-1086)tCc>tTc	p.S362F	ZKSCAN1_ENST00000535170.1_Missense_Mutation_p.S149F|ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.S326F	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	362					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGTCTGAGCTCCAACTTCACC	0.483000													36	38					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3732014	3732014	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:3732014C>T	ENST00000378230.3	-	22	3054	c.2730G>A	c.(2728-2730)ccG>ccA	p.P910P		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	910						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GTCCGCCCTTCGGGGTGGGGA	0.637000													7	10					0	0	1	0	0
ART4	420	broad.mit.edu	37	12	14993596	14993596	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:14993596G>A	ENST00000228936.4	-	2	1017	c.636C>T	c.(634-636)ctC>ctT	p.L212L	C12orf60_ENST00000527783.1_Intron	NM_021071.2	NP_066549.2	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4	212					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			large_intestine(5)|liver(1)|lung(3)|prostate(1)|skin(2)|stomach(3)	15						CTTCTTTCAGGAGGGATGTGG	0.493000													15	45					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15892465	15892465	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:15892465C>T	ENST00000375847.3	+	12	1814	c.1650C>T	c.(1648-1650)ctC>ctT	p.L550L	DNAJC16_ENST00000375838.1_Silent_p.L550L|DNAJC16_ENST00000375849.1_Silent_p.L550L|DNAJC16_ENST00000483270.1_3'UTR	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	550					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TCTTCATCCTCTTCGGCACTG	0.433000													113	146					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44209417	44209417	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:44209417C>G	ENST00000260665.7	-	2	363	c.306G>C	c.(304-306)aaG>aaC	p.K102N	LRPPRC_ENST00000409659.1_Missense_Mutation_p.K102N|LRPPRC_ENST00000409946.1_Missense_Mutation_p.K102N	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	102					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTAGAAGCTTCTTTGGAATGC	0.408000													20	64					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79356818	79356818	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:79356818C>T	ENST00000419573.3	-	2	601	c.327G>A	c.(325-327)ctG>ctA	p.L109L	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Silent_p.L109L	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	109	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCTCTGTCCTCAGCTCCAAGG	0.517000													59	95					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605943	47605943	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:47605943G>A	ENST00000263774.4	+	7	787	c.705G>A	c.(703-705)ctG>ctA	p.L235L	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	235					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	AATTTGACCTGAACAGCCCCT	0.557000													40	165					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82368724	82368724	+	Silent	SNP	G	G	A	rs142332080		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:82368724G>A	ENST00000509081.1	-	6	881	c.660C>T	c.(658-660)ctC>ctT	p.L220L	RASGEF1B_ENST00000264400.2_Silent_p.L221L|RASGEF1B_ENST00000335927.7_Silent_p.L179L			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	221	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						CAATATAATTGAGCCTCTCCT	0.443000													9	19					0	0	1	0	0
RELA	5970	broad.mit.edu	37	11	65422347	65422347	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:65422347G>A	ENST00000406246.3	-	11	1419	c.1158C>T	c.(1156-1158)gtC>gtT	p.V386V	RELA_ENST00000308639.9_Silent_p.V383V|RELA_ENST00000525693.1_3'UTR	NM_001243984.1|NM_001243985.1|NM_021975.3	NP_001230913.1|NP_001230914.1|NP_068810.3	Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	386					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						cctggggcaggacttggggag	0.662000													4	1					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27844576	27844576	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:27844576C>G	ENST00000261716.3	+	16	2329	c.1810C>G	c.(1810-1812)Ctt>Gtt	p.L604V	TAOK1_ENST00000536202.1_Intron	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	604					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			AGCTAACCTTCTTCGACGTCA	0.438000													71	202					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85777174	85777174	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:85777174C>T	ENST00000233838.4	-	15	2240	c.2160G>A	c.(2158-2160)gtG>gtA	p.V720V	GGCX_ENST00000430215.3_Silent_p.V663V	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase						blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TTGCATAAGTCACCTCCTGGG	0.473000													33	38					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19960349	19960349	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:19960349G>A	ENST00000263207.3	-	16	2843	c.2552C>T	c.(2551-2553)tCa>tTa	p.S851L	ARVCF_ENST00000406522.1_Splice_Site_p.S782L|ARVCF_ENST00000406259.1_Splice_Site_p.S845L|ARVCF_ENST00000401994.1_Splice_Site_p.S788L|ARVCF_ENST00000344269.3_Splice_Site_p.S788L	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	851					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					AGCAGCAGCTGACTGAGACAT	0.577000													24	37					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26868343	26868343	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:26868343G>A	ENST00000398145.2	-	6	1042	c.426C>T	c.(424-426)ttC>ttT	p.F142F	HPS4_ENST00000402105.3_Silent_p.F137F|HPS4_ENST00000398141.1_Silent_p.F137F|HPS4_ENST00000336873.5_Silent_p.F142F	NM_022081.5	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	142					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						TTTGCTCGATGAAGGTGTCCC	0.413000									Hermansky-Pudlak syndrome				46	95					0	0	1	0	0
GGT6	124975	broad.mit.edu	37	17	4461899	4461899	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:4461899G>A	ENST00000301395.3	-	3	856	c.797C>T	c.(796-798)gCa>gTa	p.A266V	GGT6_ENST00000381550.3_Missense_Mutation_p.A304V|GGT6_ENST00000573591.1_Missense_Mutation_p.A150V|GGT6_ENST00000574154.1_Missense_Mutation_p.A298V	NM_153338.2	NP_699169.2	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6	298					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						TAGCTGCTCTGCTGGTTCCAA	0.662000													8	5					0	0	1	0	0
PCBP1	5093	broad.mit.edu	37	2	70315024	70315024	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:70315024C>T	ENST00000303577.5	+	1	440	c.149C>T	c.(148-150)tCg>tTg	p.S50L	PCBP1-AS1_ENST00000423402.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA	NM_006196.3	NP_006187.2	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	50	KH 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|skin(1)	12						ATCAACATCTCGGAGGGGAAT	0.527000													88	116					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25074459	25074459	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:25074459G>A	ENST00000381989.3	-	4	501	c.396C>T	c.(394-396)ctC>ctT	p.L132L		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	132					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATTACTCAGTGAGTTCCACAG	0.393000													42	24					0	0	1	0	0
IZUMO2	126123	broad.mit.edu	37	19	50655892	50655892	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:50655892G>C	ENST00000293405.3	-	7	640	c.640C>G	c.(640-642)Caa>Gaa	p.Q214E		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	214						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TTTCGGTTTTGTCTGTATGTA	0.408000													85	275					0	0	1	0	0
CST8	10047	broad.mit.edu	37	20	23472337	23472337	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:23472337C>T	ENST00000246012.1	+	2	390	c.33C>T	c.(31-33)ctC>ctT	p.L11L		NM_005492.2	NP_005483.1	O60676	CST8_HUMAN	cystatin 8 (cystatin-related epididymal specific)	11						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(9)|skin(2)	16	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CCCTGATCCTCCTCACCATTC	0.582000													67	136					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41616856	41616856	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:41616856C>T	ENST00000216237.5	+	7	995	c.837C>T	c.(835-837)atC>atT	p.I279I		NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	279					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACAGCAAGATCCTAGTGCCCC	0.532000													30	65					0	0	1	0	0
DNM1P34	729809	broad.mit.edu	37	15	75594859	75594859	+	RNA	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:75594859C>A	ENST00000567292.1	-	0	447																											TGAGACCAACCATGAGGTCCC	0.597000													7	29					3.09899e-07	3.15196e-07	1	1	0
DPP8	54878	broad.mit.edu	37	15	65748600	65748600	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:65748600C>T	ENST00000341861.5	-	16	3709	c.2129G>A	c.(2128-2130)cGa>cAa	p.R710Q	DPP8_ENST00000300141.6_Missense_Mutation_p.R694Q|DPP8_ENST00000559233.1_Missense_Mutation_p.R710Q|DPP8_ENST00000339244.5_Missense_Mutation_p.R537Q|DPP8_ENST00000321147.6_Missense_Mutation_p.R710Q|DPP8_ENST00000358939.4_Intron|DPP8_ENST00000321118.7_Intron	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	710					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TTTAAGCCCTCGGTGACAGGA	0.393000													41	64					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113078589	113078589	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:113078589G>C	ENST00000316851.7	+	6	751	c.751G>C	c.(751-753)Gag>Cag	p.E251Q	NCAM1_ENST00000533760.1_Missense_Mutation_p.E143Q|NCAM1_ENST00000401611.2_Missense_Mutation_p.E260Q|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	261	Ig-like C2-type 3.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GGAAGACGATGAGAAGTACAT	0.433000													3	13					0	0	1	0	0
RNH1	6050	broad.mit.edu	37	11	494697	494697	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:494697G>A	ENST00000534797.1	-	9	2787	c.1380C>T	c.(1378-1380)atC>atT	p.I460I	RNH1_ENST00000356187.5_Silent_p.I460I|RNH1_ENST00000354420.2_Silent_p.I460I|RNH1_ENST00000397604.3_Silent_p.I460I|RNH1_ENST00000438658.2_Silent_p.I460I|RNH1_ENST00000397615.2_Silent_p.I460I|RNH1_ENST00000533410.1_Silent_p.I460I|RNH1_ENST00000397614.1_Silent_p.I460I			P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor 1	460					mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCCTCAGGAGATGACCCTCA	0.627000													38	114					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094612	143094612	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:143094612C>T	ENST00000367603.2	-	5	2006	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	HIVEP2_ENST00000367604.1_Missense_Mutation_p.E422K|HIVEP2_ENST00000012134.2_Missense_Mutation_p.E422K	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ATGATTTCTTCATAAGACTTT	0.468000													30	66					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518581	113518581	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:113518581G>C	ENST00000284601.3	-	4	2634	c.2566C>G	c.(2566-2568)Caa>Gaa	p.Q856E		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	856					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GTTGCTTTTTGATATTCTGTA	0.373000													29	120					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	35047442	35047442	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:35047442C>T	ENST00000360359.3	+	15	2571	c.2433C>T	c.(2431-2433)gtC>gtT	p.V811V	ANKS1A_ENST00000470698.1_3'UTR|ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	811	SAM 2.					cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						TAGAGCTCGTCAATGTGAGTA	0.607000													14	46					0	0	1	0	0
SNURF	8926	broad.mit.edu	37	15	25213157	25213157	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:25213157C>T	ENST00000338094.6	+	3	250	c.189C>T	c.(187-189)ttC>ttT	p.F63F	SNURF_ENST00000338327.4_Silent_p.F63F|SNRPN_ENST00000400100.1_5'UTR|SNRPN_ENST00000577565.1_5'UTR|SNRPN_ENST00000400098.1_5'UTR|SNRPN_ENST00000390687.4_5'UTR|SNRPN_ENST00000553597.1_3'UTR|SNURF_ENST00000551312.2_Silent_p.F63F|SNRPN_ENST00000400097.1_5'UTR|SNRPN_ENST00000554227.2_5'UTR|SNRPN_ENST00000346403.6_5'UTR|SNURF_ENST00000577949.1_Silent_p.F63F	NM_003097.3|NM_005678.3	NP_003088.1|NP_005669.2			SNRPN upstream reading frame											breast(2)|large_intestine(2)|lung(1)	5		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		GGCAGGCATTCTTAGCTGAGA	0.468000													4	56					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131973864	131973864	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:131973864G>A	ENST00000378823.3	+	23	3968	c.3150G>A	c.(3148-3150)ctG>ctA	p.L1050L	RAD50_ENST00000265335.6_Silent_p.L1189L|AC004041.2_ENST00000435042.1_RNA|AC004041.2_ENST00000458509.1_RNA|AC004041.2_ENST00000457489.1_RNA|AC004041.2_ENST00000417516.1_RNA	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	1189					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGGTGATGCTGAAGGGAGACA	0.458000								Homologous recombination					28	46					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210578017	210578017	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:210578017C>G	ENST00000367010.1	+	6	905	c.678C>G	c.(676-678)atC>atG	p.I226M	HHAT_ENST00000541565.1_Intron|HHAT_ENST00000545154.1_Missense_Mutation_p.I227M|HHAT_ENST00000261458.3_Missense_Mutation_p.I226M|HHAT_ENST00000391905.3_Missense_Mutation_p.I226M|HHAT_ENST00000537898.1_Missense_Mutation_p.I161M|HHAT_ENST00000413764.2_Missense_Mutation_p.I226M|HHAT_ENST00000545781.1_Missense_Mutation_p.I163M|HHAT_ENST00000308852.6_Missense_Mutation_p.I181M	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	226					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		CGGAGTTCATCAAACAGGTAG	0.498000													22	31					0	0	1	0	0
PCGF1	84759	broad.mit.edu	37	2	74734008	74734008	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:74734008C>T	ENST00000233630.6	-	3	1114	c.203G>A	c.(202-204)tGc>tAc	p.C68Y	PCGF1_ENST00000480844.2_5'UTR	NM_032673.2	NP_116062.2	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1	68	No repressor activity.				histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(2)	12						ACAACTCTTGCAGACTGCAGG	0.522000													38	33					0	0	1	0	0
ZNF136	7695	broad.mit.edu	37	19	12298526	12298526	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:12298526G>A	ENST00000343979.4	+	4	1473	c.1333G>A	c.(1333-1335)Gag>Aag	p.E445K	ZNF136_ENST00000398616.2_Missense_Mutation_p.E379K	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	445					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						TCATACTGGAGAGAAACCCTA	0.383000													15	31					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30976085	30976085	+	Missense_Mutation	SNP	C	C	T	rs138671480	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:30976085C>T	ENST00000262519.8	+	7	1708	c.1022C>T	c.(1021-1023)tCc>tTc	p.S341F		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	341	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						tccgcctcttcctcctcattg	0.572000													65	90					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	128923778	128923778	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:128923778C>T	ENST00000280333.6	+	26	2710	c.2601C>T	c.(2599-2601)ctC>ctT	p.L867L		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	867					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCGATCAGCTCAAGTACCATC	0.552000													14	7					0	0	1	0	0
TRAV13-2	28670	broad.mit.edu	37	14	22386707	22386707	+	RNA	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:22386707C>G	ENST00000390439.2	+	0	186																											GGTGACAACTCTATTATCAAC	0.443000													14	22					0	0	1	0	0
TBC1D13	54662	broad.mit.edu	37	9	131566275	131566275	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:131566275C>T	ENST00000372648.5	+	9	945	c.795C>T	c.(793-795)ctC>ctT	p.L265L	TBC1D13_ENST00000539497.1_Silent_p.L84L|TBC1D13_ENST00000223865.8_Intron	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	265	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						TCACCAACCTCATGGCCGAGA	0.562000													28	65					0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4944429	4944429	+	RNA	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:4944429C>T	ENST00000592666.1	+	0	1848							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		TCCCGGGGATCCCCGTGGGCA	0.647000													24	42					0	0	1	0	0
TMEM249	340393	broad.mit.edu	37	8	145579212	145579212	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:145579212G>A	ENST00000531225.1	-	1	57	c.58C>T	c.(58-60)Cac>Tac	p.H20Y	FBXL6_ENST00000526524.1_5'UTR|FBXL6_ENST00000331890.5_Silent_p.L533L|FBXL6_ENST00000455319.2_Silent_p.L527L					transmembrane protein 249																		AGGGGCTGGTGAGCAGCTGCT	0.612000													37	64					0	0	1	0	0
DMTF1	9988	broad.mit.edu	37	7	86823347	86823347	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:86823347G>C	ENST00000414194.2	+	16	2951	c.1159G>C	c.(1159-1161)Gaa>Caa	p.E387Q	DMTF1_ENST00000432937.2_Missense_Mutation_p.E565Q|DMTF1_ENST00000331242.7_Missense_Mutation_p.E653Q|DMTF1_ENST00000394703.5_Missense_Mutation_p.E653Q|DMTF1_ENST00000413276.2_Missense_Mutation_p.E583Q			Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	653	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Myb-like 2.|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					CAGAACAGAAGAAGAAATCTC	0.383000													53	45					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144897496	144897496	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:144897496G>A	ENST00000356994.2	-	1	53	c.47C>T	c.(46-48)tCg>tTg	p.S16L	SCRIB_ENST00000320476.3_Missense_Mutation_p.S16L	NM_182706.4	NP_874365	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	16	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CTTGTCCACCGACTCCACGTG	0.731000													6	14					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148563061	148563061	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:148563061C>T	ENST00000506113.1	+	2	542	c.60C>T	c.(58-60)gtC>gtT	p.V20V	RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000504238.1_Silent_p.V20V|ABLIM3_ENST00000326685.7_Silent_p.V20V|ABLIM3_ENST00000356541.3_Silent_p.V20V|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000508983.1_Silent_p.V20V|ABLIM3_ENST00000309868.7_Silent_p.V20V			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	20					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCCAATGTCATCCAGTGCT	0.498000													20	35					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70841605	70841605	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:70841605C>T	ENST00000393567.2	-	86	15394	c.15244G>A	c.(15244-15246)Gaa>Aaa	p.E5082K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	5082										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGGTTTCCTTCAAAGGAGACT	0.517000													17	82					0	0	1	0	0
NRN1L	123904	broad.mit.edu	37	16	67919692	67919692	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:67919692C>T	ENST00000339176.3	+	2	246	c.147C>T	c.(145-147)ttC>ttT	p.F49F	NRN1L_ENST00000576147.1_5'UTR|CTC-479C5.10_ENST00000572067.1_lincRNA	NM_198443.1	NP_940845.1	Q496H8	NRN1L_HUMAN	neuritin 1-like	49						anchored to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		ACCAGGGCTTCGCCGAGTGTC	0.652000													5	88					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38746205	38746205	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:38746205C>G	ENST00000359357.3	+	12	1607	c.1353C>G	c.(1351-1353)atC>atG	p.I451M	DNAH8_ENST00000449981.2_Missense_Mutation_p.I668M|DNAH8_ENST00000441566.1_Missense_Mutation_p.I451M					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTGGGAAAATCTTATCTTCTC	0.289000													14	40					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62652683	62652683	+	Nonsense_Mutation	SNP	C	C	T	rs147281603		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:62652683C>T	ENST00000377892.1	+	10	1473	c.1249C>T	c.(1249-1251)Cag>Tag	p.Q417*	SLC3A2_ENST00000536981.1_5'UTR|SLC3A2_ENST00000538682.1_3'UTR|SLC3A2_ENST00000535296.1_Nonsense_Mutation_p.Q355*|SLC3A2_ENST00000338663.7_Nonsense_Mutation_p.Q285*|SLC3A2_ENST00000377889.2_Nonsense_Mutation_p.Q324*|SLC3A2_ENST00000377891.2_Nonsense_Mutation_p.Q387*|SLC3A2_ENST00000377890.2_Nonsense_Mutation_p.Q386*			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	386					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						CTCCGACCTTCAGCAGATCCT	0.522000													41	60					0	0	1	0	0
CLDN25	644672	broad.mit.edu	37	11	113650715	113650715	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:113650715C>T	ENST00000453129.2	+	1	247	c.198C>T	c.(196-198)gcC>gcT	p.A66A		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	66						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						TGTGCAAGGCCTTTGAATCCT	0.562000													51	57					0	0	1	0	0
ATP5A1	498	broad.mit.edu	37	18	43667111	43667111	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:43667111G>A	ENST00000593152.2	-	8	1428	c.889C>T	c.(889-891)Cgg>Tgg	p.R297W	ATP5A1_ENST00000282050.2_Missense_Mutation_p.R347W|ATP5A1_ENST00000590665.1_Missense_Mutation_p.R325W|ATP5A1_ENST00000398752.6_Missense_Mutation_p.R347W	NM_001257335.1	NP_001244264.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	347					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						TCCAGCAACCGGGAGTGTAGG	0.527000													23	55					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24903175	24903175	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:24903175G>C	ENST00000313367.2	-	8	1168	c.717C>G	c.(715-717)ctC>ctG	p.L239L	OSBPL3_ENST00000396429.1_Silent_p.L239L|OSBPL3_ENST00000431825.2_Silent_p.L239L|OSBPL3_ENST00000353930.1_Silent_p.L239L|OSBPL3_ENST00000396431.1_Silent_p.L239L|OSBPL3_ENST00000352860.1_Silent_p.L239L|OSBPL3_ENST00000409069.1_Silent_p.L239L	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	239					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						TGCTTTGCAGGAGCTGGCTCA	0.552000													52	55					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11554453	11554453	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:11554453C>T	ENST00000262442.4	+	13	2233	c.2165C>T	c.(2164-2166)gCa>gTa	p.A722V	DNAH9_ENST00000454412.2_Missense_Mutation_p.A722V	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9		Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.A722G(1)		NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCTGAGACAGCAGCAGCCATG	0.448000													82	44					0	0	1	0	0
POLR3E	55718	broad.mit.edu	37	16	22337394	22337394	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:22337394C>T	ENST00000299853.5	+	18	1828	c.1661C>T	c.(1660-1662)gCc>gTc	p.A554V	POLR3E_ENST00000359210.4_Missense_Mutation_p.A554V|POLR3E_ENST00000564209.1_Missense_Mutation_p.A554V|POLR3E_ENST00000418581.2_Missense_Mutation_p.A518V	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	554					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		CAGGGCTGCGCCAGCACCCCT	0.657000													8	42					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46661436	46661436	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:46661436G>A	ENST00000544460.1	+	1	5825	c.5571G>A	c.(5569-5571)caG>caA	p.Q1857Q	TDRD6_ENST00000316081.6_Silent_p.Q1857Q	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1857					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TTGAGTTACAGAATTCTCTGG	0.448000													16	51					0	0	1	0	0
KBTBD4	55709	broad.mit.edu	37	11	47599018	47599018	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:47599018C>T	ENST00000533290.1	-	1	1323	c.609G>A	c.(607-609)caG>caA	p.Q203Q	KBTBD4_ENST00000430070.2_Silent_p.Q194Q|KBTBD4_ENST00000526005.1_Silent_p.Q178Q|KBTBD4_ENST00000525720.1_Silent_p.Q227Q|KBTBD4_ENST00000395288.2_Silent_p.Q178Q|NDUFS3_ENST00000533507.1_Intron			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	178	BACK.									NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						CCTCTGTATTCTGCAGCTGGG	0.537000													35	111					0	0	1	0	0
TMEM216	51259	broad.mit.edu	37	11	61165262	61165262	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:61165262C>T	ENST00000515837.2	+	4	1191	c.246C>T	c.(244-246)ctC>ctT	p.L82L	TMEM216_ENST00000334888.5_Silent_p.L82L|TMEM216_ENST00000398979.3_Silent_p.L21L			Q9P0N5	TM216_HUMAN	transmembrane protein 216	75						integral to membrane				endometrium(1)|large_intestine(2)|lung(1)|prostate(2)	6						AGGGAAACCTCTGCCAGCGAA	0.552000													18	75					0	0	1	0	0
DCAF16	54876	broad.mit.edu	37	4	17805577	17805577	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:17805577G>A	ENST00000382247.1	-	3	1248	c.188C>T	c.(187-189)tCc>tTc	p.S63F	DCAF16_ENST00000536863.1_Missense_Mutation_p.S63F	NM_017741.3	NP_060211.3	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	63						CUL4 RING ubiquitin ligase complex				cervix(1)|endometrium(1)|lung(2)|ovary(1)	5						CCAAGTTGTGGAATATTTTAA	0.438000													18	76					0	0	1	0	0
COG2	22796	broad.mit.edu	37	1	230822834	230822834	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:230822834C>T	ENST00000534989.1	+	13	1692	c.1357C>T	c.(1357-1359)Cag>Tag	p.Q453*	COG2_ENST00000546013.1_Nonsense_Mutation_p.Q201*|COG2_ENST00000366668.3_Nonsense_Mutation_p.Q512*|COG2_ENST00000535166.1_Nonsense_Mutation_p.Q396*|COG2_ENST00000366669.4_Nonsense_Mutation_p.Q512*			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	512					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTCCCGCACTCAGCTCGTGTA	0.488000													9	42					0	0	1	0	0
COMT	1312	broad.mit.edu	37	22	19951112	19951112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:19951112C>T	ENST00000361682.6	+	4	695	c.313C>T	c.(313-315)Cag>Tag	p.Q105*	COMT_ENST00000403184.1_Nonsense_Mutation_p.Q105*|COMT_ENST00000449653.1_Nonsense_Mutation_p.Q55*|COMT_ENST00000403710.1_Nonsense_Mutation_p.Q105*|COMT_ENST00000406520.3_Nonsense_Mutation_p.Q105*|COMT_ENST00000493893.1_3'UTR|COMT_ENST00000407537.1_Nonsense_Mutation_p.Q55*	NM_000754.3	NP_000745.1	P21964	COMT_HUMAN	catechol-O-methyltransferase	105					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			kidney(1)|lung(1)|ovary(1)|prostate(1)|stomach(1)	5	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	CGCCGTGATTCAGGAGCACCA	0.667000													17	44					0	0	1	0	0
ZNF565	147929	broad.mit.edu	37	19	36673472	36673472	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:36673472G>A	ENST00000355114.5	-	5	2242	c.1516C>T	c.(1516-1518)Cag>Tag	p.Q506*	ZNF565_ENST00000304116.5_Nonsense_Mutation_p.Q466*|ZNF565_ENST00000392173.2_Nonsense_Mutation_p.Q466*			Q8N9K5	ZN565_HUMAN	zinc finger protein 565	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(4)|ovary(1)|skin(2)	11	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TGAATTCTCTGATGTTCGGTA	0.423000													13	36					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5657277	5657277	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:5657277C>T	ENST00000292123.5	+	14	1888	c.1781C>T	c.(1780-1782)tCa>tTa	p.S594L	SAFB_ENST00000538656.1_Missense_Mutation_p.S437L|SAFB_ENST00000454510.1_Missense_Mutation_p.S525L|SAFB_ENST00000433404.1_Missense_Mutation_p.S424L|SAFB_ENST00000592224.1_Missense_Mutation_p.S594L|SAFB_ENST00000588852.1_Missense_Mutation_p.S594L	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	594	Interaction with POLR2A.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GATCGCAAATCAGCCAGCAGA	0.498000													12	29					0	0	1	0	0
C1QTNF3-AMACR	100534612	broad.mit.edu	37	5	34033411	34033411	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:34033411G>A	ENST00000382079.3	-	3	375	c.301C>T	c.(301-303)Cag>Tag	p.Q101*	C1QTNF3_ENST00000382065.3_Nonsense_Mutation_p.Q190*|C1QTNF3_ENST00000231338.7_Nonsense_Mutation_p.Q117*|C1QTNF3_ENST00000513065.1_5'UTR						117																	TGGTTTACCTGAAGTTCTGGT	0.597000													15	13					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1255117	1255117	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:1255117G>A	ENST00000348261.5	+	11	2703	c.2455G>A	c.(2455-2457)Gag>Aag	p.E819K	CACNA1H_ENST00000565831.1_Missense_Mutation_p.E819K|CACNA1H_ENST00000358590.4_Missense_Mutation_p.E819K	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	819					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCTGCAGCCCGAGGAGCTGAC	0.657000													16	30					0	0	1	0	0
TSSK4	283629	broad.mit.edu	37	14	24677184	24677184	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:24677184G>A	ENST00000339917.5	+	4	1053	c.849G>A	c.(847-849)caG>caA	p.Q283Q	TSSK4_ENST00000287913.6_Silent_p.Q273Q|TSSK4_ENST00000556621.1_Silent_p.Q197Q|TSSK4_ENST00000428351.2_Silent_p.Q80Q|TM9SF1_ENST00000530611.1_Intron|TM9SF1_ENST00000556387.1_Intron	NM_001184739.1|NM_174944.3	NP_001171668.1|NP_777604.2	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	273	Protein kinase.				cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8				GBM - Glioblastoma multiforme(265;0.018)		TGATCCTCCAGATGCTACGCC	0.527000													21	32					0	0	1	0	0
IL17RB	55540	broad.mit.edu	37	3	53883693	53883693	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:53883693G>C	ENST00000288167.3	+	3	106	c.97G>C	c.(97-99)Gag>Cag	p.E33Q		NM_018725.3	NP_061195.2	Q9NRM6	I17RB_HUMAN	interleukin 17 receptor B	33					defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		GCCATCTCCAGAGTGGATGCT	0.488000													44	80					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204226578	204226578	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:204226578G>A	ENST00000272203.3	-	9	1743	c.1427C>T	c.(1426-1428)tCa>tTa	p.S476L	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.S496L	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	476										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGCACTGGGTGAGCGGACAGG	0.657000													3	5					0	0	1	0	0
NDUFB4	4710	broad.mit.edu	37	3	120315260	120315260	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:120315260C>T	ENST00000485064.1	+	1	86	c.54C>T	c.(52-54)ctC>ctT	p.L18L	NDUFB4_ENST00000184266.2_Silent_p.L18L|NDUFB4_ENST00000492739.1_Silent_p.L18L	NM_001168331.1	NP_001161803.1	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	18					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|large_intestine(1)|lung(3)	5				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	CTGAGACCCTCGACCCAGCCG	0.587000													17	31					0	0	1	0	0
AK3	50808	broad.mit.edu	37	9	4718472	4718472	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:4718472G>A	ENST00000381809.3	-	4	740	c.510C>T	c.(508-510)atC>atT	p.I170I	AK3_ENST00000447596.4_Silent_p.I130I|AK3_ENST00000359883.2_Silent_p.I100I	NM_016282.3	NP_057366.2	Q9UIJ7	KAD3_HUMAN	adenylate kinase 3	170					blood coagulation	mitochondrial matrix	ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity			large_intestine(2)|lung(1)|ovary(2)	5	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0302)		TTAGTCTCTTGATAACCGTCT	0.433000													24	39					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45736388	45736388	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:45736388C>T	ENST00000403390.1	+	10	1058	c.1058C>T	c.(1057-1059)tCt>tTt	p.S353F	PFKL_ENST00000349048.4_Missense_Mutation_p.S306F			P17858	K6PL_HUMAN	phosphofructokinase, liver	306					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GGGACGCCCTCTGCCTTCGAC	0.657000													27	18					0	0	1	0	0
POGK	57645	broad.mit.edu	37	1	166818540	166818540	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:166818540C>T	ENST00000367875.1	+	5	1084	c.724C>T	c.(724-726)Caa>Taa	p.Q242*	POGK_ENST00000536514.1_Nonsense_Mutation_p.Q157*|POGK_ENST00000537173.1_Nonsense_Mutation_p.Q124*|POGK_ENST00000367876.4_Nonsense_Mutation_p.Q242*			Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	242					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	22						GCCACAGCTTCAAAACGCCCA	0.542000													33	37					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64518837	64518837	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:64518837G>A	ENST00000164139.3	-	16	2327	c.1929C>T	c.(1927-1929)gtC>gtT	p.V643V	PYGM_ENST00000377432.3_Silent_p.V555V|PYGM_ENST00000462303.1_5'UTR	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	643					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	CCAGGAAGATGACACGGAGGC	0.582000													47	31					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72246433	72246433	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:72246433G>A	ENST00000441391.2	+	4	1302	c.90G>A	c.(88-90)ctG>ctA	p.L30L	TTYH2_ENST00000269346.4_Silent_p.L351L|TTYH2_ENST00000529107.1_Silent_p.L330L	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2	351						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						AGCTCCTGCTGAACTCCTCAG	0.622000													7	23					0	0	1	0	0
C1orf174	339448	broad.mit.edu	37	1	3807144	3807144	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:3807144C>G	ENST00000361605.3	-	3	705	c.607G>C	c.(607-609)Gag>Cag	p.E203Q	C1orf174_ENST00000486765.1_5'UTR	NM_207356.2	NP_997239.2	Q8IYL3	CA174_HUMAN	chromosome 1 open reading frame 174	203										endometrium(1)|large_intestine(5)|lung(4)|prostate(1)	11	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;5.09e-25)|all_epithelial(116;9.35e-17)|all_lung(118;1.09e-06)|Lung NSC(185;0.000139)|all_neural(13;0.00287)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0219)|all_hematologic(16;0.027)|Colorectal(325;0.0276)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;1.55e-39)|OV - Ovarian serous cystadenocarcinoma(86;5.99e-23)|GBM - Glioblastoma multiforme(42;2.22e-17)|Colorectal(212;1.08e-05)|COAD - Colon adenocarcinoma(227;5.49e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000365)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.19)		TGCATGAGCTCAACGTTTCCA	0.542000													23	45					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31812998	31812998	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:31812998C>T	ENST00000446923.2	+	8	3082	c.2691C>T	c.(2689-2691)ttC>ttT	p.F897F	ZEB1_ENST00000542815.3_Silent_p.F846F|ZEB1_ENST00000560721.2_Silent_p.F893F|ZEB1_ENST00000320985.10_Silent_p.F913F|ZEB1_ENST00000361642.5_Silent_p.F914F	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	913					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				ACAAGATATTCCAAAAGAGTA	0.358000													25	55					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21826373	21826373	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:21826373C>G	ENST00000328843.6	+	60	9781	c.9750C>G	c.(9748-9750)gtC>gtG	p.V3250V	DNAH11_ENST00000409508.3_Silent_p.V3243V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3250	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CAGCTAAAGTCTTCATGGGAA	0.463000									Kartagener syndrome				97	77					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39208572	39208572	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:39208572C>T	ENST00000252699.2	+	11	1225	c.1149C>T	c.(1147-1149)atC>atT	p.I383I	ACTN4_ENST00000390009.3_Silent_p.I164I|ACTN4_ENST00000424234.2_Intron	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	383					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCCAGGACATCAACAATGGCT	0.612000													6	10					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88818908	88818908	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:88818908G>A	ENST00000277865.4	-	10	1497	c.1401C>T	c.(1399-1401)ctC>ctT	p.L467L	GLUD1_ENST00000544149.1_Splice_Site_p.L334L|GLUD1_ENST00000537649.1_Splice_Site_p.L300L	NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	467					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	GATACTCACTGAGCAAGTGGT	0.408000													46	52					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6640684	6640684	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:6640684C>T	ENST00000377674.4	+	2	173	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_001278647.1|NM_001278648.1|NM_005341.2	NP_001265576.1|NP_001265577.1|NP_005332.1	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	5						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		ACGGCTCCTTCGTCCAGCACA	0.612000													27	33					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23499958	23499958	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:23499958G>A	ENST00000309859.4	-	6	630	c.548C>T	c.(547-549)tCc>tTc	p.S183F	GGA2_ENST00000567468.1_Missense_Mutation_p.S183F	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	183					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		ATCAAAGATGGAGCTCTTGGG	0.408000													35	68					0	0	1	0	0
CCT4	10575	broad.mit.edu	37	2	62103250	62103250	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:62103250G>A	ENST00000394440.3	-	8	1193	c.897C>T	c.(895-897)ctC>ctT	p.L299L	CCT4_ENST00000544079.1_Silent_p.L269L|CCT4_ENST00000544185.1_Silent_p.L149L|CCT4_ENST00000538252.1_Silent_p.L243L|CCT4_ENST00000461540.2_5'UTR|AC107081.5_ENST00000425779.1_RNA	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	299					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			ATTTCTGTATGAGAAGGACAT	0.338000													17	37					0	0	1	0	0
NADK	65220	broad.mit.edu	37	1	1696732	1696732	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:1696732G>A	ENST00000344463.4	-	2	335	c.114C>T	c.(112-114)atC>atT	p.I38I	NADK_ENST00000378625.1_Silent_p.I38I|NADK_ENST00000341991.3_Silent_p.I38I|NADK_ENST00000341426.5_Silent_p.I38I|NADK_ENST00000492768.1_5'UTR			O95544	NADK_HUMAN	NAD kinase	38					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CCCGGCCCCGGATGGGGTGGT	0.572000													36	53					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292785	102292785	+	RNA	SNP	C	C	G	rs61084368		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:102292785C>G	ENST00000561463.1	+	0	831																		p.Q125E(1)									TGCTGCTTCTCAGAGCTGCTG	0.602000													3	22					0	0	1	0	0
HNRNPD	3184	broad.mit.edu	37	4	83278012	83278012	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:83278012G>C	ENST00000313899.7	-	6	1067	c.790C>G	c.(790-792)Cag>Gag	p.Q264E	HNRNPD_ENST00000508119.1_5'UTR|HNRNPD_ENST00000543098.1_Missense_Mutation_p.Q212E|HNRNPD_ENST00000352301.4_Missense_Mutation_p.Q245E|HNRNPD_ENST00000541060.1_Missense_Mutation_p.Q110E|HNRNPD_ENST00000353341.4_Missense_Mutation_p.Q264E	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	264					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						TGCTGTTGCTGATATTGTTCC	0.368000													86	143					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	3879436	3879436	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:3879436C>T	ENST00000324333.10	-	7	2016	c.1823G>A	c.(1822-1824)gGa>gAa	p.G608E	GLIS3_ENST00000461870.1_5'UTR|GLIS3_ENST00000381971.3_Missense_Mutation_p.G763E	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	608					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		CCTCTCAGCTCCTGCGTCCAC	0.532000													45	59					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45755816	45755816	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:45755816C>G	ENST00000357450.4	-	18	2730	c.2731G>C	c.(2731-2733)Gaa>Caa	p.E911Q	SMC1B_ENST00000404354.3_Missense_Mutation_p.E911Q	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	911					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CTTACAACTTCTTTTTGCAAT	0.338000													4	29					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62194406	62194406	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:62194406G>A	ENST00000467148.1	-	8	5838	c.5769C>T	c.(5767-5769)ttC>ttT	p.F1923F	HELZ2_ENST00000427522.2_Silent_p.F1354F	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CACGGCCTGAGAAGCAGTCTC	0.697000													7	11					0	0	1	0	0
GEMIN2	8487	broad.mit.edu	37	14	39597505	39597505	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:39597505G>C	ENST00000308317.6	+	7	669	c.586G>C	c.(586-588)Gaa>Caa	p.E196Q	GEMIN2_ENST00000250379.8_Missense_Mutation_p.E181Q|GEMIN2_ENST00000396249.2_Missense_Mutation_p.E196Q	NM_003616.2	NP_003607.1	O14893	GEMI2_HUMAN	gem (nuclear organelle) associated protein 2	196					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding										TAGTGTCTTGGAATATCTGAG	0.313000													21	37					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6048631	6048631	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:6048631G>A	ENST00000265849.7	-	1	125	c.20C>T	c.(19-21)tCg>tTg	p.S7L	PMS2_ENST00000406569.3_Missense_Mutation_p.S7L|PMS2_ENST00000469652.1_5'UTR|PMS2_ENST00000382321.4_Missense_Mutation_p.S7L	NM_000535.5	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	7					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CGCTCACCTCGAGCTCTCAGC	0.657000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				58	59					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52376322	52376322	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:52376322G>C	ENST00000420592.1	-	6	2077	c.744C>G	c.(742-744)ttC>ttG	p.F248L	ZNF577_ENST00000451628.2_Missense_Mutation_p.F248L|ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000301399.5_Missense_Mutation_p.F307L			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		ACTTAAAATAGAAGGTTCTTC	0.433000													37	92					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862489	14862489	+	Silent	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:14862489G>T	ENST00000285046.5	+	1	2021	c.1911G>T	c.(1909-1911)ctG>ctT	p.L637L	FGD5_ENST00000543601.1_Silent_p.L396L	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	637					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCTCACTCCTGATCGAGAGCG	0.532000													36	70					3.33393e-15	3.4474e-15	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22157006	22157006	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:22157006A>C	ENST00000397126.4	-	4	978	c.830T>G	c.(829-831)aTa>aGa	p.I277R	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGTATGAATTATCTTATGTTT	0.373000													14	30					0	0	1	0	0
TSPAN33	340348	broad.mit.edu	37	7	128802296	128802296	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:128802296C>T	ENST00000289407.4	+	3	331	c.222C>T	c.(220-222)ctC>ctT	p.L74L		NM_178562.3	NP_848657.1	Q86UF1	TSN33_HUMAN	tetraspanin 33	74						integral to membrane				NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14						TGGGTGTCCTCATGTTCCTGC	0.632000													28	24					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32109375	32109375	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:32109375G>A	ENST00000375250.5	-	10	1723	c.1482C>T	c.(1480-1482)ctC>ctT	p.L494L	ARHGAP12_ENST00000311380.4_Silent_p.L472L|ARHGAP12_ENST00000396144.4_Silent_p.L519L|ARHGAP12_ENST00000492028.1_5'UTR|ARHGAP12_ENST00000375245.4_Silent_p.L472L|ARHGAP12_ENST00000344936.2_Silent_p.L524L	NM_001270696.1|NM_001270698.1	NP_001257625.1|NP_001257627.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	524	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				TTGCCCCCTTGAGGTCCACTG	0.333000													19	26					0	0	1	0	0
KIAA0247	9766	broad.mit.edu	37	14	70170135	70170135	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:70170135G>A	ENST00000342745.4	+	3	458	c.145G>A	c.(145-147)Gag>Aag	p.E49K		NM_014734.3	NP_055549.1	Q92537	K0247_HUMAN	KIAA0247	49	Sushi.					integral to membrane				endometrium(1)|kidney(1)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)	10				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		ACCGGAGCCAGAGAATGGTGG	0.587000													48	102					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39034176	39034176	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:39034176C>G	ENST00000355481.4	+	85	11899	c.11768C>G	c.(11767-11769)tCc>tGc	p.S3923C	RYR1_ENST00000359596.3_Missense_Mutation_p.S3928C|RYR1_ENST00000360985.3_Missense_Mutation_p.S3923C	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3928					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CACCAGGAATCCATCAGCGAC	0.602000													20	42					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84088150	84088150	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:84088150G>A	ENST00000343411.3	-	23	3558	c.3063C>T	c.(3061-3063)atC>atT	p.I1021I		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	1021					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TGGCCTTGTTGATTTGTACCA	0.612000													8	41					0	0	1	0	0
DIS3L	115752	broad.mit.edu	37	15	66615076	66615076	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:66615076G>C	ENST00000319194.5	+	10	1390	c.1129G>C	c.(1129-1131)Gaa>Caa	p.E377Q	DIS3L_ENST00000441424.2_3'UTR|RP11-352G18.2_ENST00000565993.1_RNA|DIS3L_ENST00000319212.4_Missense_Mutation_p.E460Q	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	460					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GGTGAGTCCTGAAGAGGAACA	0.428000													22	39					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131025344	131025344	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:131025344C>T	ENST00000421699.2	-	12	892	c.880G>A	c.(880-882)Gac>Aac	p.D294N	GOLGA2_ENST00000609374.1_Missense_Mutation_p.D282N	NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	294						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						CTGAGGGCGTCTCTCTCTTTG	0.537000													30	55					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55473552	55473552	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:55473552C>G	ENST00000394600.3	-	11	1763	c.1027G>C	c.(1027-1029)Gaa>Caa	p.E343Q	MTIF2_ENST00000263629.4_Missense_Mutation_p.E343Q|MTIF2_ENST00000403721.1_Missense_Mutation_p.E343Q	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	343					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						TCTAACATTTCTGCAAGAGCA	0.368000													43	70					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55508420	55508420	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:55508420G>A	ENST00000474267.1	-	5	1150	c.629C>T	c.(628-630)tCc>tTc	p.S210F	WNT5A_ENST00000264634.4_Missense_Mutation_p.S210F|WNT5A_ENST00000497027.1_Missense_Mutation_p.S195F			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	210					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		ACTCTCGTAGGAGCCCTTGGC	0.662000													12	29					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171710424	171710424	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:171710424C>G	ENST00000358196.3	+	14	1855	c.1305C>G	c.(1303-1305)ctC>ctG	p.L435L		NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	435					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAGGATACCTCTTCCAGCCAG	0.493000													64	34					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42991566	42991566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:42991566G>A	ENST00000252115.5	-	6	972	c.868C>T	c.(868-870)Cga>Tga	p.R290*	POLDIP3_ENST00000491021.1_5'UTR|POLDIP3_ENST00000339677.6_Intron|POLDIP3_ENST00000348657.2_Nonsense_Mutation_p.R261*|POLDIP3_ENST00000451060.2_Nonsense_Mutation_p.R134*	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	290	RRM.				positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						TCAGTGACTCGAGGGTGCAGA	0.483000													26	48					0	0	1	0	0
NUDT9	53343	broad.mit.edu	37	4	88344102	88344102	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:88344102C>T	ENST00000302174.4	+	1	369	c.45C>T	c.(43-45)ctC>ctT	p.L15L	NUDT9_ENST00000473942.1_Intron	NM_024047.4	NP_076952.1	Q9BW91	NUDT9_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 9	15						mitochondrion	ADP-ribose diphosphatase activity			endometrium(1)|large_intestine(4)|lung(6)	11		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		CGGTGTCTCTCTCTCTGGCCT	0.637000													34	49					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160952912	160952912	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:160952912C>G	ENST00000447678.1	-	40	6092	c.5972G>C	c.(5971-5973)gGa>gCa	p.G1991A	LPA_ENST00000316300.5_Missense_Mutation_p.G1991A	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4499	Kringle 18.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CAGAGGCCCTCCACTGTCACC	0.458000													23	20					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21967254	21967254	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:21967254C>T	ENST00000298717.4	-	10	1697	c.1546G>A	c.(1546-1548)Gaa>Aaa	p.E516K	TOX4_ENST00000262709.3_3'UTR|TOX4_ENST00000405508.1_3'UTR	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	516					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CCATAGATTTCATCTGGTTTA	0.398000													15	36					0	0	1	0	0
C7orf26	79034	broad.mit.edu	37	7	6639964	6639964	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:6639964C>G	ENST00000344417.5	+	4	1352	c.1085C>G	c.(1084-1086)tCa>tGa	p.S362*	C7orf26_ENST00000472693.1_3'UTR|C7orf26_ENST00000359073.5_Nonsense_Mutation_p.S265*	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	362										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		GCCATGGCCTCAGGAGCTCTG	0.667000													23	21					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46654550	46654550	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:46654550C>G	ENST00000371992.1	-	23	2738	c.2088G>C	c.(2086-2088)ctG>ctC	p.L696L	POMGNT1_ENST00000371984.3_3'UTR|POMGNT1_ENST00000535522.1_3'UTR|POMGNT1_ENST00000371986.3_Silent_p.L696L|POMGNT1_ENST00000396420.3_3'UTR	NM_001243766.1	NP_001230695	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	0					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					GCCCCACCCTCAGGGCAGCAT	0.557000													16	41					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103162566	103162566	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:103162566C>T	ENST00000424685.2	-	48	7730	c.7571G>A	c.(7570-7572)cGa>cAa	p.R2524Q	RELN_ENST00000343529.5_Missense_Mutation_p.R2524Q|RELN_ENST00000428762.1_Missense_Mutation_p.R2524Q			P78509	RELN_HUMAN	reelin	2524					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGATGGAGCTCGATTGAAGTT	0.547000													12	77					0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109477397	109477397	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:109477397G>C	ENST00000369971.2	-	11	1680	c.1551C>G	c.(1549-1551)ctC>ctG	p.L517L	CLCC1_ENST00000369969.2_Silent_p.L396L|CLCC1_ENST00000369970.3_Silent_p.L467L|CLCC1_ENST00000415331.1_Silent_p.L467L|CLCC1_ENST00000369968.2_Silent_p.L332L|CLCC1_ENST00000302500.4_Silent_p.L396L|CLCC1_ENST00000356970.2_Silent_p.L517L|CLCC1_ENST00000482889.1_Intron|CLCC1_ENST00000348264.2_Silent_p.L332L|CLCC1_ENST00000369976.1_Intron|AKNAD1_ENST00000357393.4_Intron	NM_001048210.1	NP_001041675.1	Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	517						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CTTCAGACTTGAGCTGGGCCT	0.597000													49	88					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655464	19655464	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19655464G>A	ENST00000586018.1	+	8	2230	c.2128G>A	c.(2128-2130)Ggc>Agc	p.G710S	CILP2_ENST00000291495.5_Missense_Mutation_p.G704S			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	704						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GGGGTCCTCGGGCCCCCGGGT	0.716000													8	10					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17124285	17124285	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:17124285G>A	ENST00000265970.7	-	23	3774	c.3775C>T	c.(3775-3777)Cga>Tga	p.R1259*	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Nonsense_Mutation_p.R879*	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1259	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	CCCGTGCTTCGAAGCATTATA	0.403000													20	47					0	0	1	0	0
VPS37B	79720	broad.mit.edu	37	12	123380580	123380580	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:123380580G>A	ENST00000267202.2	-	1	411	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_024667.2	NP_078943.1	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37 homolog B (S. cerevisiae)	10					cellular membrane organization|endosome transport|protein transport	late endosome membrane				breast(1)|central_nervous_system(1)|large_intestine(1)|skin(1)|urinary_tract(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		ACAGCCCGGCGAACCGGGCTT	0.721000													29	42					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347112	140347112	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:140347112C>G	ENST00000289269.5	+	1	1293	c.761C>G	c.(760-762)tCt>tGt	p.S254C	PCDHA13_ENST00000289272.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		254	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACTCTCCTGCCTTT	0.612000													26	69					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120585990	120585990	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:120585990G>C	ENST00000300648.6	-	37	4719	c.4707C>G	c.(4705-4707)atC>atG	p.I1569M		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1569					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGGGTTCCTGATAACGGAGC	0.602000													14	25					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42180422	42180422	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:42180422C>T	ENST00000401548.3	+	25	3207	c.3167C>T	c.(3166-3168)tCa>tTa	p.S1056L	MEI1_ENST00000300398.4_Missense_Mutation_p.S64L|MEI1_ENST00000400107.1_Missense_Mutation_p.S389L|MEI1_ENST00000476893.1_3'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	1056							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GCACTACTCTCAGGTATGGGT	0.483000													19	42					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153909176	153909176	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:153909176C>G	ENST00000361217.4	-	16	2699	c.2281G>C	c.(2281-2283)Gag>Cag	p.E761Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	761										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCCCACAGCTCAGGCACAGCT	0.597000													8	15					0	0	1	0	0
MYO1D	4642	broad.mit.edu	37	17	30932242	30932242	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:30932242G>A	ENST00000318217.5	-	21	3031	c.2727C>T	c.(2725-2727)gtC>gtT	p.V909V	MYO1D_ENST00000394649.4_Silent_p.V821V|MYO1D_ENST00000579584.1_Silent_p.V909V	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	909						myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TTCCATTGGAGACACTCAGAC	0.408000													31	48					0	0	1	0	0
VN1R2	317701	broad.mit.edu	37	19	53761945	53761945	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:53761945C>T	ENST00000341702.3	+	1	401	c.317C>T	c.(316-318)tCa>tTa	p.S106L		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	106					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		GGGAATTTTTCACTCTTATAT	0.448000													5	28					0	0	1	0	0
ANXA5	308	broad.mit.edu	37	4	122589652	122589652	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:122589652G>C	ENST00000296511.5	-	13	1219	c.934C>G	c.(934-936)Ctt>Gtt	p.L312V	ANXA5_ENST00000515017.1_Missense_Mutation_p.L212V|ANXA5_ENST00000501272.2_Missense_Mutation_p.L252V	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	312					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						AGCAGCAGAAGAGCTTTCTTA	0.463000													24	36					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75894123	75894123	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:75894123G>C	ENST00000388802.4	+	9	924	c.715G>C	c.(715-717)Gag>Cag	p.E239Q	SRRM3_ENST00000326382.8_Missense_Mutation_p.E239Q					serine/arginine repetitive matrix 3									p.E239*(1)		NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						GAAGAACAAAGAgaagaagag	0.552000													40	29					0	0	1	0	0
MLYCD	23417	broad.mit.edu	37	16	83933169	83933169	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:83933169C>T	ENST00000262430.4	+	1	439	c.420C>T	c.(418-420)ctC>ctT	p.L140L		NM_012213.2	NP_036345.2	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase	140					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						ATCGCGGCCTCTTCCACCACA	0.736000													11	22					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112904	57112904	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:57112904G>A	ENST00000454682.1	-	3	2691	c.2410C>T	c.(2410-2412)Cag>Tag	p.Q804*	NACA_ENST00000548563.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTTTTAGTCTGAGGAGACACA	0.483000			T	BCL6	NHL								7	22					0	0	1	0	0
ZNF432	9668	broad.mit.edu	37	19	52538020	52538020	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:52538020G>A	ENST00000594154.1	-	5	1124	c.912C>T	c.(910-912)ctC>ctT	p.L304L	ZNF432_ENST00000221315.5_Silent_p.L304L			O94892	ZN432_HUMAN	zinc finger protein 432	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GATGTACAATGAGATTACGCT	0.418000													53	71					0	0	1	0	0
TSN	7247	broad.mit.edu	37	2	122520632	122520632	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:122520632C>T	ENST00000389682.3	+	5	672	c.425C>T	c.(424-426)tCa>tTa	p.S142L	TSN_ENST00000409193.1_Missense_Mutation_p.S137L|TSN_ENST00000536142.1_Intron|TSN_ENST00000498545.1_3'UTR	NM_001261401.1|NM_004622.2	NP_001248330.1|NP_004613.1	Q15631	TSN_HUMAN	translin	142					DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding	p.S142L(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)|skin(1)	12		Ovarian(717;0.0563)|Prostate(154;0.116)				GATTATCTCTCAGGAGTTCTA	0.358000													19	11					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32505160	32505160	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:32505160C>T	ENST00000327300.7	+	8	1387	c.1220C>T	c.(1219-1221)tCt>tTt	p.S407F	KHDRBS1_ENST00000307714.8_3'UTR|KHDRBS1_ENST00000492989.1_Missense_Mutation_p.S368F	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	407					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GTTCAAGATTCTTATGAAGCT	0.418000													25	100					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9803411	9803411	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:9803411C>T	ENST00000256460.3	-	6	637	c.460G>A	c.(460-462)Gaa>Aaa	p.E154K	OGG1_ENST00000302036.7_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000349503.5_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	154	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TTGGAGTCTTCATCCAGGCTG	0.562000													22	45					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	437485	437485	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:437485G>A	ENST00000338977.5	-	2	783	c.735C>T	c.(733-735)gtC>gtT	p.V245V	ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000507078.1_Intron|ZNF721_ENST00000506646.1_Intron|ZNF721_ENST00000511833.2_Silent_p.V257V					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						ATGAGGAAATGACTTTGCCAC	0.368000													10	27					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50720304	50720304	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:50720304G>A	ENST00000449103.1	-	20	3464	c.3324C>T	c.(3322-3324)gtC>gtT	p.V1108V	PLXNB2_ENST00000359337.4_Silent_p.V1108V			O15031	PLXB2_HUMAN	plexin B2	1108					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity	p.V1151V(1)		breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGAGCTTGTTGACCTGCTTCT	0.647000													17	48					0	0	1	0	0
DCAF12	25853	broad.mit.edu	37	9	34088385	34088385	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:34088385G>A	ENST00000361264.4	-	9	1666	c.1325C>T	c.(1324-1326)tCa>tTa	p.S442L	RP11-537H15.3_ENST00000448245.1_RNA	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	442						centrosome|CUL4 RING ubiquitin ligase complex				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						ATGGAGCCCTGAAGGGAGGGG	0.458000													70	128					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18232507	18232507	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:18232507G>A	ENST00000262811.6	+	3	84	c.84G>A	c.(82-84)ggG>ggA	p.G28G	MAST3_ENST00000608648.1_3'UTR	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3								ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GCCGCAGCGGGAACCGCAAGA	0.687000													47	94					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424197	91424197	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:91424197C>T	ENST00000268171.3	+	15	1998	c.1719C>T	c.(1717-1719)acC>acT	p.T573T		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	573	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TCTATGGCACCGCCCCTGAGG	0.612000													56	88					0	0	1	0	0
CAST	831	broad.mit.edu	37	5	96084256	96084256	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:96084256C>T	ENST00000395813.1	+	19	1553	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	CAST_ENST00000359176.4_Missense_Mutation_p.S437L|CAST_ENST00000508830.1_Missense_Mutation_p.S456L|CAST_ENST00000510756.1_Missense_Mutation_p.S434L|CAST_ENST00000348386.3_3'UTR|CAST_ENST00000338252.3_Missense_Mutation_p.S360L|CAST_ENST00000511782.1_Missense_Mutation_p.S359L|CAST_ENST00000508608.1_Missense_Mutation_p.S419L|CAST_ENST00000508579.1_Missense_Mutation_p.S88L|CAST_ENST00000511049.1_Missense_Mutation_p.S359L|CAST_ENST00000395812.2_Missense_Mutation_p.S415L|CAST_ENST00000309190.5_Missense_Mutation_p.S351L|CAST_ENST00000515663.1_Missense_Mutation_p.S96L|CAST_ENST00000325674.7_Missense_Mutation_p.S421L|CAST_ENST00000341926.3_Missense_Mutation_p.S373L|CAST_ENST00000509903.1_Missense_Mutation_p.S338L|CAST_ENST00000504465.1_Missense_Mutation_p.S301L	NM_001284213.1	NP_001271142.1	P20810	ICAL_HUMAN	calpastatin	373							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		GATGAACTTTCAGAAGATTTT	0.323000													26	29					0	0	1	0	0
BTF3	689	broad.mit.edu	37	5	72798795	72798795	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:72798795C>T	ENST00000380591.3	+	4	589	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	BTF3_ENST00000335895.8_Nonsense_Mutation_p.Q80*|BTF3_ENST00000514505.2_3'UTR	NM_001037637.1	NP_001032726.1	P20290	BTF3_HUMAN	basic transcription factor 3	124	NAC-A/B.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(2)	5		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CCCTAAAGTTCAGGCATCTCT	0.418000													45	60					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23316917	23316917	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:23316917C>T	ENST00000597761.2	+	2	238	c.39C>T	c.(37-39)ttC>ttT	p.F13F	ZNF730_ENST00000593635.1_5'UTR	NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						CCATAGAATTCTCTCTGGAGG	0.408000													19	72					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19959443	19959443	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:19959443G>C	ENST00000263207.3	-	18	3038	c.2747C>G	c.(2746-2748)tCt>tGt	p.S916C	ARVCF_ENST00000406522.1_Missense_Mutation_p.S847C|ARVCF_ENST00000406259.1_Missense_Mutation_p.S910C|ARVCF_ENST00000401994.1_Missense_Mutation_p.S853C|ARVCF_ENST00000344269.3_Missense_Mutation_p.S853C	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	916					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CTCTCCTGCAGAGCTGGCGCC	0.652000													23	45					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256992	69256992	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:69256992G>T	ENST00000439696.2	-	2	576	c.275C>A	c.(274-276)tCg>tAg	p.S92*	ZFP36L1_ENST00000336440.3_Nonsense_Mutation_p.S92*|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	92					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCCCCTTCCGAGAAGGAGCG	0.672000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	51					1.2644e-06	1.2851e-06	1	1	0
RASEF	158158	broad.mit.edu	37	9	85677430	85677430	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:85677430G>A	ENST00000376447.3	-	1	613	c.353C>T	c.(352-354)tCg>tTg	p.S118L	RASEF_ENST00000340717.4_Missense_Mutation_p.S118L	NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	118					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding	p.S118L(1)		NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						CGGGCCGCACGAGGTGGCCAG	0.721000													17	24					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138333769	138333769	+	Silent	SNP	G	G	A	rs140188327	byFrequency	TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:138333769G>A	ENST00000421622.1	-	4	496	c.288C>T	c.(286-288)atC>atT	p.I96I	SVOPL_ENST00000419765.3_Silent_p.I216I|SVOPL_ENST00000288513.5_Silent_p.I64I|SVOPL_ENST00000436657.1_Silent_p.I64I			Q8N434	SVOPL_HUMAN	SVOP-like	216						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						TGAAGGCCACGATGAGGATGA	0.597000													23	23					0	0	1	0	0
AGAP6	414189	broad.mit.edu	37	10	51749101	51749101	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:51749101C>T	ENST00000412531.3	+	2	329	c.257C>T	c.(256-258)tCa>tTa	p.S86L	AGAP6_ENST00000374056.4_Intron	NM_001077665.2	NP_001071133.2	C9IYN2	C9IYN2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6	86					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(8)|prostate(3)|skin(1)|stomach(2)	29						AATCCAGAGTCAAGCACAATA	0.343000													21	54					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47894742	47894742	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:47894742G>A	ENST00000426837.2	-	20	6884	c.6797C>T	c.(6796-6798)tCa>tTa	p.S2266L	MAP4_ENST00000264724.11_Missense_Mutation_p.S856L|MAP4_ENST00000360240.6_Missense_Mutation_p.S1121L|MAP4_ENST00000383737.4_Missense_Mutation_p.S780L|MAP4_ENST00000420772.2_Intron|MAP4_ENST00000395734.3_Intron|MAP4_ENST00000441748.2_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	1121					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GCCACTGGCTGAAGTGGGGGC	0.667000													31	54					0	0	1	0	0
GUF1	60558	broad.mit.edu	37	4	44700657	44700657	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:44700657G>C	ENST00000281543.5	+	17	2163	c.1969G>C	c.(1969-1971)Gat>Cat	p.D657H	GUF1_ENST00000506793.1_3'UTR	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)	657					translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						AGTTCCAAAAGATGCTTTTAT	0.328000													17	24					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47783764	47783764	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:47783764G>A	ENST00000359568.5	+	14	2631	c.2524G>A	c.(2524-2526)Gag>Aag	p.E842K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	842					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding	p.E842*(1)|p.E842K(1)|p.E842Q(1)		NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTGTGGGCGGGAGCCGCCCAC	0.662000													114	74					0	0	1	0	0
C5orf38	153571	broad.mit.edu	37	5	2752818	2752818	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:2752818G>C	ENST00000515640.1	+	2	302	c.283G>C	c.(283-285)Gag>Cag	p.E95Q	C5orf38_ENST00000505778.1_Missense_Mutation_p.E95Q|C5orf38_ENST00000334000.3_Missense_Mutation_p.E95Q|C5orf38_ENST00000457752.2_Intron|C5orf38_ENST00000397835.4_Missense_Mutation_p.E95Q|IRX2_ENST00000502957.1_5'UTR			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	95						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		CAGTCACGTCGAGAACGGGCA	0.602000													55	92					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7401401	7401401	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:7401401C>G	ENST00000322644.6	+	8	1606	c.1207C>G	c.(1207-1209)Caa>Gaa	p.Q403E	POLR2A_ENST00000572844.1_Missense_Mutation_p.Q403E	NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	403					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				TCCTAGACTTCAAGAACTAGT	0.507000													54	34					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94918476	94918476	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:94918476C>T	ENST00000536441.1	-	5	1042	c.706G>A	c.(706-708)Gat>Aat	p.D236N	RP11-712B9.2_ENST00000534891.1_RNA|SESN3_ENST00000278499.2_Missense_Mutation_p.D97N|SESN3_ENST00000416495.2_Missense_Mutation_p.D236N|SESN3_ENST00000393234.1_Missense_Mutation_p.D236N|RP11-712B9.2_ENST00000534864.1_RNA	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	236					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TTAGCAAGATCACAAACGCAG	0.363000													84	70					0	0	1	0	0
FZD5	7855	broad.mit.edu	37	2	208633056	208633056	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:208633056G>A	ENST00000295417.3	-	2	961	c.408C>T	c.(406-408)ctC>ctT	p.L136L		NM_003468.3	NP_003459.2	Q13467	FZD5_HUMAN	frizzled family receptor 5	136	FZ.				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			NS(1)|kidney(1)|lung(1)|ovary(2)|prostate(1)|skin(1)	7				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		CCAGCACCGGGAGGCGGTCGC	0.731000													4	3					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150768813	150768813	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:150768813G>A	ENST00000485713.1	+	15	3269	c.2229G>A	c.(2227-2229)ctG>ctA	p.L743L	SLC4A2_ENST00000461735.1_Silent_p.L729L|SLC4A2_ENST00000413384.2_Silent_p.L743L|SLC4A2_ENST00000310317.5_Silent_p.L661L|SLC4A2_ENST00000392826.2_Silent_p.L734L	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	743	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTCGGAGCTGATTATGTCCA	0.657000													74	61					0	0	1	0	0
C6orf211	79624	broad.mit.edu	37	6	151779664	151779664	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:151779664G>C	ENST00000367294.3	+	3	608	c.349G>C	c.(349-351)Gaa>Caa	p.E117Q	C6orf211_ENST00000483931.1_3'UTR|C6orf211_ENST00000545879.1_5'UTR	NM_024573.1	NP_078849.1	Q9H993	CF211_HUMAN	chromosome 6 open reading frame 211	117							protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(7)	15			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		GTTGTTGGTAGAATGTTACAT	0.318000													13	13					0	0	1	0	0
WDR83	84292	broad.mit.edu	37	19	12780690	12780690	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:12780690G>T	ENST00000418543.3	+	3	435	c.86G>T	c.(85-87)cGa>cTa	p.R29L	WDR83OS_ENST00000596731.1_5'UTR|WDR83_ENST00000242796.4_Missense_Mutation_p.R29L	NM_001099737.2	NP_001093207.1	Q9BRX9	WDR83_HUMAN	WD repeat domain 83	29					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				breast(2)|large_intestine(1)|lung(1)	4						GGGGCAGTGCGAGCCGTACGA	0.642000													51	154					1.32667e-27	1.38385e-27	1	1	0
NT5DC2	64943	broad.mit.edu	37	3	52558849	52558849	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:52558849C>G	ENST00000307076.4	-	13	1685	c.1285G>C	c.(1285-1287)Gag>Cag	p.E429Q	NT5DC2_ENST00000422318.2_Missense_Mutation_p.E466Q|NT5DC2_ENST00000459839.1_Missense_Mutation_p.E441Q|NT5DC2_ENST00000307092.4_Missense_Mutation_p.E370Q	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	429							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TCCTGCCGCTCTTTCATCCAG	0.657000													32	76					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103070858	103070858	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:103070858G>A	ENST00000374902.4	-	13	2565	c.2389C>T	c.(2389-2391)Ctg>Ttg	p.L797L	TEX10_ENST00000535814.1_Silent_p.L800L	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	797						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CAAGAAGCCAGAAATGGCAGT	0.398000													35	83					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31741457	31741457	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:31741457G>A	ENST00000266269.5	-	1	761	c.132C>T	c.(130-132)ctC>ctT	p.L44L	PATZ1_ENST00000405309.3_Silent_p.L44L|PATZ1_ENST00000351933.4_Silent_p.L44L|PATZ1_ENST00000215919.3_Silent_p.L44L	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	44	BTB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						CTACCCGCAAGAGCACGTCGC	0.647000													5	16					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48874023	48874023	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:48874023C>G	ENST00000394754.1	+	8	3046	c.2932C>G	c.(2932-2934)Ctg>Gtg	p.L978V	GTF2A1L_ENST00000403751.3_Missense_Mutation_p.L274V|GTF2A1L_ENST00000430487.2_Missense_Mutation_p.L240V|LHCGR_ENST00000420913.3_Intron|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.L931V|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.L978V|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.L978V|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.L978V	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		931					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGCTCAAAATCTGCATGATGA	0.443000													35	56					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102980456	102980456	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:102980456C>G	ENST00000375735.2	+	1	297	c.153C>G	c.(151-153)ctC>ctG	p.L51L	DYNC2H1_ENST00000398093.3_Silent_p.L51L|DYNC2H1_ENST00000334267.7_Silent_p.L51L	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	51	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGATGCTCCTCAGGGTGCAGC	0.532000													15	18					0	0	1	0	0
SLC2A1	6513	broad.mit.edu	37	1	43393372	43393372	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:43393372G>A	ENST00000426263.3	-	9	1360	c.1182C>T	c.(1180-1182)ctC>ctT	p.L394L	SLC2A1_ENST00000475162.1_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	394					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CCTGGCTGAAGAGTTCAGCCA	0.542000													9	39					0	0	1	0	0
PMM2	5373	broad.mit.edu	37	16	8941644	8941644	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:8941644G>A	ENST00000268261.4	+	8	769	c.703G>A	c.(703-705)Gag>Aag	p.E235K	PMM2_ENST00000539622.1_Missense_Mutation_p.E152K|RP11-152P23.2_ENST00000567942.1_RNA|PMM2_ENST00000566983.1_Missense_Mutation_p.E208K|PMM2_ENST00000537352.1_Missense_Mutation_p.E110K|PMM2_ENST00000569958.1_Missense_Mutation_p.E144K	NM_000303.2	NP_000294.1	O15305	PMM2_HUMAN	phosphomannomutase 2	235					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			breast(3)|cervix(1)|endometrium(2)|large_intestine(1)|ovary(1)|skin(1)	9						GACAGCGCCTGAGGACACGCG	0.602000													22	71					0	0	1	0	0
NAT10	55226	broad.mit.edu	37	11	34167637	34167637	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:34167637G>A	ENST00000257829.3	+	29	3182	c.2976G>A	c.(2974-2976)aaG>aaA	p.K992K	NAT10_ENST00000527971.1_Intron|NAT10_ENST00000531159.2_Silent_p.K920K|NAT10_ENST00000532555.1_3'UTR	NM_024662.2	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	992	Lys-rich.|Required for localization to the nucleolus and midbody.					nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				CTAGTGACAAGAAAAGGAAGT	0.348000													7	10					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194118121	194118121	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:194118121C>G	ENST00000401815.1	-	1	962	c.891G>C	c.(889-891)ctG>ctC	p.L297L	GP5_ENST00000323007.3_Silent_p.L297L			P40197	GPV_HUMAN	glycoprotein V (platelet)	297					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GGGTGCGGTTCAGCCACAGCT	0.672000													11	24					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103804753	103804753	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:103804753G>A	ENST00000216554.3	+	7	1205	c.529G>A	c.(529-531)Gag>Aag	p.E177K	EIF5_ENST00000392715.2_Missense_Mutation_p.E177K|EIF5_ENST00000558506.1_Missense_Mutation_p.E177K	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	177					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			ATCCAGCAGTGAGAcaccacc	0.433000													5	10					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110429501	110429501	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:110429501C>G	ENST00000360185.4	-	2	281	c.117G>C	c.(115-117)cgG>cgC	p.R39R	GIT2_ENST00000457474.2_Silent_p.R39R|GIT2_ENST00000355312.3_Silent_p.R39R|GIT2_ENST00000338373.5_Silent_p.R39R|GIT2_ENST00000551209.1_Silent_p.R39R|GIT2_ENST00000361006.5_Silent_p.R39R|GIT2_ENST00000343646.5_Silent_p.R39R|GIT2_ENST00000354574.4_Silent_p.R39R|GIT2_ENST00000547815.1_Silent_p.R39R|GIT2_ENST00000356259.4_Silent_p.R39R|GIT2_ENST00000320063.9_Silent_p.R39R|GIT2_ENST00000553118.1_Silent_p.R39R	NM_014776.3	NP_055591.2	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	39	Arf-GAP.				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GCCCTAGACTCCGATGGACAC	0.493000													14	51					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71724592	71724592	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:71724592G>A	ENST00000393524.2	-	3	1172	c.439C>T	c.(439-441)Cgt>Tgt	p.R147C	PHLPP2_ENST00000568954.1_Missense_Mutation_p.R147C|PHLPP2_ENST00000356272.3_Missense_Mutation_p.R147C|PHLPP2_ENST00000567016.1_Missense_Mutation_p.R182C|PHLPP2_ENST00000360429.3_Missense_Mutation_p.R147C			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	147				R -> C (in Ref. 3; BX647823).		cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CGATCCAAACGATCCATGTGG	0.418000													8	31					0	0	1	0	0
MTMR1	8776	broad.mit.edu	37	X	149905822	149905822	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:149905822C>G	ENST00000445323.2	+	12	1496	c.1375C>G	c.(1375-1377)Ctg>Gtg	p.L459V	MTMR1_ENST00000538506.1_Missense_Mutation_p.L276V|MTMR1_ENST00000541925.1_Missense_Mutation_p.L357V|MTMR1_ENST00000370390.3_Missense_Mutation_p.L451V|MTMR1_ENST00000544228.1_Missense_Mutation_p.L451V|MTMR1_ENST00000451863.2_Missense_Mutation_p.L451V			Q13613	MTMR1_HUMAN	myotubularin related protein 1	451	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCACATCTCTGGCTATGCT	0.463000													51	23					0	0	1	0	0
XPO7	23039	broad.mit.edu	37	8	21859708	21859708	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:21859708G>C	ENST00000434536.1	+	25	2997	c.2895G>C	c.(2893-2895)aaG>aaC	p.K965N	XPO7_ENST00000433566.4_Missense_Mutation_p.K957N|XPO7_ENST00000252512.9_Missense_Mutation_p.K956N			Q9UIA9	XPO7_HUMAN	exportin 7	956					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		GCACCAAGAAGAGGACCACAC	0.537000													8	24					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256370	69256370	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:69256370G>C	ENST00000439696.2	-	2	1198	c.897C>G	c.(895-897)ctC>ctG	p.L299L	ZFP36L1_ENST00000336440.3_Silent_p.L299L|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	299					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCTGGTCCGAGAGAGAATCCT	0.642000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	117					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92926917	92926917	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:92926917C>G	ENST00000373079.3	-	1	1650	c.1387G>C	c.(1387-1389)Gat>Cat	p.D463H	NAP1L3_ENST00000475430.2_Missense_Mutation_p.D456H	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	463					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						AAGTCCTCATCCAGGATAGCA	0.403000													11	5					0	0	1	0	0
ZBTB33	10009	broad.mit.edu	37	X	119387422	119387422	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:119387422C>T	ENST00000326624.2	+	2	380	c.152C>T	c.(151-153)tCa>tTa	p.S51L	ZBTB33_ENST00000557385.1_Missense_Mutation_p.S51L	NM_006777.3	NP_006768.1	Q86T24	KAISO_HUMAN	zinc finger and BTB domain containing 33	51	BTB.|Interaction with NCOR1.|Self-association (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						AATATTCTTTCAGCTTCTAGT	0.428000													81	29					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978531	58978531	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:58978531C>T	ENST00000361050.3	-	1	1893	c.1808G>A	c.(1807-1809)aGt>aAt	p.S603N		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	603						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GGCAGCCTGACTCATGAGGGG	0.567000													51	172					0	0	1	0	0
ELMO3	79767	broad.mit.edu	37	16	67237768	67237768	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:67237768C>T	ENST00000393997.2	+	20	2367	c.2310C>T	c.(2308-2310)atC>atT	p.I770I	ELMO3_ENST00000477898.1_Silent_p.I604I|ELMO3_ENST00000360833.1_Silent_p.I753I	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	717					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		ACTGCAGCATCGCTGAACCTT	0.642000													6	7					0	0	1	0	0
OSM	5008	broad.mit.edu	37	22	30660086	30660086	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:30660086G>A	ENST00000215781.2	-	3	585	c.545C>T	c.(544-546)tCg>tTg	p.S182L	OSM_ENST00000403389.1_Missense_Mutation_p.S161L|OSM_ENST00000403463.1_3'UTR	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	182					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			AAAAGCATCCGAGGCAGGGGT	0.647000													13	27					0	0	1	0	0
TBC1D13	54662	broad.mit.edu	37	9	131565699	131565699	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:131565699C>T	ENST00000372648.5	+	8	864	c.714C>T	c.(712-714)ctC>ctT	p.L238L	TBC1D13_ENST00000539497.1_Silent_p.L57L|TBC1D13_ENST00000223865.8_Intron|TBC1D13_ENST00000466056.1_3'UTR	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	238	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						TGGGGCCCCTCTACTACACCT	0.577000													20	51					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15715751	15715751	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:15715751G>A	ENST00000396368.3	-	12	2684	c.2478C>T	c.(2476-2478)ctC>ctT	p.L826L	KIAA0430_ENST00000602337.1_Silent_p.L823L|KIAA0430_ENST00000548025.1_Silent_p.L823L|KIAA0430_ENST00000540441.2_Silent_p.L661L|KIAA0430_ENST00000344181.3_Silent_p.L495L|KIAA0430_ENST00000551742.1_Silent_p.L826L	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	825	RRM.					peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TATGGGGGCTGAGCTCAACAC	0.453000													15	41					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11182125	11182125	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:11182125G>A	ENST00000361445.4	-	48	6797	c.6721C>T	c.(6721-6723)Ccc>Tcc	p.P2241S	MTOR_ENST00000376838.1_Missense_Mutation_p.P446S	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2241	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TCACAGTGGGGAACCCAGCCA	0.537000													17	54					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21427462	21427462	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:21427462G>A	ENST00000313654.9	+	32	4207	c.3966G>A	c.(3964-3966)atG>atA	p.M1322I	LAMA3_ENST00000399516.3_Missense_Mutation_p.M1322I	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1322	Domain III B.|Laminin EGF-like 10.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGAAGAGATGACGGGGCAGT	0.632000													30	65					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32120448	32120448	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:32120448C>T	ENST00000373672.3	-	68	4818	c.4302G>A	c.(4300-4302)gtG>gtA	p.V1434V	RP11-73M7.6_ENST00000609033.1_RNA|RP11-73M7.6_ENST00000609338.1_RNA|RP11-73M7.6_ENST00000610043.1_RNA|COL16A1_ENST00000271069.6_Silent_p.V1434V|RP11-73M7.6_ENST00000608332.1_RNA|RP11-73M7.6_ENST00000589462.1_RNA|RP11-73M7.6_ENST00000593188.1_RNA|RP11-73M7.6_ENST00000609373.1_RNA|RP11-73M7.6_ENST00000585413.1_RNA|COL16A1_ENST00000461217.1_5'UTR|RP11-73M7.6_ENST00000591929.1_RNA|RP11-73M7.6_ENST00000591592.1_RNA|RP11-73M7.6_ENST00000585660.1_RNA|RP11-73M7.6_ENST00000610216.1_RNA|RP11-73M7.6_ENST00000608246.1_RNA|RP11-73M7.6_ENST00000608888.1_RNA|RP11-73M7.6_ENST00000609625.1_RNA|RP11-73M7.6_ENST00000607926.1_RNA|RP11-73M7.6_ENST00000587445.1_RNA|RP11-73M7.6_ENST00000609549.1_RNA	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1434	Nonhelical region 2 (NC2).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CATCATAATTCACCATGTCTC	0.453000													55	99					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117868972	117868972	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:117868972C>G	ENST00000297338.2	-	7	1014	c.727G>C	c.(727-729)Gat>Cat	p.D243H		NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	243					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					GGGGGATCATCAAAGATACCG	0.403000													28	61					0	0	1	0	0
TFAP4	7023	broad.mit.edu	37	16	4322723	4322723	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:4322723G>A	ENST00000204517.6	-	1	353	c.25C>T	c.(25-27)Cag>Tag	p.Q9*		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	9					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						GGCACCTTCTGAGTGGGCACC	0.547000													6	30					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75501194	75501194	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:75501194C>T	ENST00000567617.1	+	1	2805	c.2805C>T	c.(2803-2805)acC>acT	p.T935T	C15orf39_ENST00000360639.2_Intron|C15orf39_ENST00000394987.4_Intron			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	0										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						CAGTGGCCACCGGAGCTGTGT	0.647000													3	17					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17827154	17827154	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:17827154G>A	ENST00000325083.8	+	22	3920	c.3481G>A	c.(3481-3483)Gaa>Aaa	p.E1161K	PCM1_ENST00000519253.1_Missense_Mutation_p.E1161K|PCM1_ENST00000524226.1_Missense_Mutation_p.E1162K	NM_006197.3	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	1161					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		TACACCCAGTGAACAGCAGCA	0.373000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								26	61					0	0	1	0	0
SLC41A1	254428	broad.mit.edu	37	1	205779453	205779453	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:205779453G>A	ENST00000367137.3	-	2	1131	c.117C>T	c.(115-117)ttC>ttT	p.F39F		NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	39						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			CAGGCCCCAGGAACTCTGAGG	0.647000											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	68					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541190	40541190	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:40541190C>A	ENST00000434248.1	-	5	1641	c.1576G>T	c.(1576-1578)Gag>Tag	p.E526*	ZNF780B_ENST00000221355.6_Nonsense_Mutation_p.E378*	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAGGGCTTCTCACCAGTGTGA	0.423000													24	69					1.10513e-12	1.1378e-12	1	1	0
OAZ1	4946	broad.mit.edu	37	19	2273075	2273075	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:2273075G>A	ENST00000583542.4	+	6	753	c.679G>A	c.(679-681)Gag>Aag	p.E227K	OAZ1_ENST00000582888.4_Missense_Mutation_p.E217K|OAZ1_ENST00000602676.2_Missense_Mutation_p.E219K|OAZ1_ENST00000322297.4_Missense_Mutation_p.E218K|OAZ1_ENST00000588673.2_Missense_Mutation_p.E248K			P54368	OAZ1_HUMAN	ornithine decarboxylase antizyme 1						polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	ornithine decarboxylase inhibitor activity			endometrium(1)|lung(2)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	L-Ornithine(DB00129)	CTACACGTTCGAGAGAGAGTC	0.627000													7	23					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323084	31323084	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:31323084G>C	ENST00000269197.5	+	12	3272	c.3272G>C	c.(3271-3273)gGa>gCa	p.G1091A		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1091					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GGAAGTCCAGGAGAGGGTGGA	0.582000													22	80					0	0	1	0	0
TRAV12-3	28672	broad.mit.edu	37	14	22434231	22434231	+	RNA	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:22434231C>T	ENST00000390442.3	+	0	340																											AAGTATATCTCCTTGTTCATC	0.488000													69	137					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54665850	54665850	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:54665850G>A	ENST00000376591.4	-	11	1823	c.1692C>T	c.(1690-1692)ttC>ttT	p.F564F	TMC4_ENST00000301187.4_Silent_p.F558F|TMC4_ENST00000416963.1_Silent_p.F146F	NM_001145303.1|NM_144686.2	NP_001138775|NP_653287.2	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	564						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					tcttcagGTAGAAAAGCAGCA	0.597000													18	26					0	0	1	0	0
TCEA3	6920	broad.mit.edu	37	1	23710889	23710889	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:23710889C>T	ENST00000450454.2	-	10	1094	c.988G>A	c.(988-990)Gag>Aag	p.E330K		NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	330					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		GTCATGGGCTCATCAGCACTG	0.498000													34	157					0	0	1	0	0
ZNF385C	201181	broad.mit.edu	37	17	40180165	40180165	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:40180165C>G	ENST00000436535.3	-	6	1070	c.1070G>C	c.(1069-1071)aGa>aCa	p.R357T	ZNF385C_ENST00000461831.1_5'UTR					zinc finger protein 385C											lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	3		all_cancers(22;0.00127)|Breast(137;0.00104)|all_epithelial(22;0.0126)				CCCTGTGACTCTCTTGGCTTT	0.682000													34	59					0	0	1	0	0
RAD51C	5889	broad.mit.edu	37	17	56780672	56780672	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:56780672C>T	ENST00000337432.4	+	4	758	c.687C>T	c.(685-687)ttC>ttT	p.F229F	RAD51C_ENST00000487921.1_3'UTR|RAD51C_ENST00000583539.1_Silent_p.F229F	NM_058216.1	NP_478123.1	O43502	RA51C_HUMAN	RAD51 paralog C	229					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity			upper_aerodigestive_tract(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTCCAGATTTCCTTTCAGAAC	0.338000								Homologous recombination	Hereditary Breast-Ovarian Cancer, non-BRCA1/2				13	65					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47861946	47861946	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:47861946G>A	ENST00000378460.2	-	3	555	c.509C>T	c.(508-510)tCc>tTc	p.S170F	NUP160_ENST00000530326.1_Missense_Mutation_p.S56F|NUP160_ENST00000526870.1_Missense_Mutation_p.S170F|NUP160_ENST00000532747.1_Intron|NUP160_ENST00000528071.1_Missense_Mutation_p.S56F	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	170					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						ATACATCCGGGAGGGGTGTGG	0.418000													21	41					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87437544	87437544	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:87437544C>T	ENST00000517970.1	+	10	1461	c.1154C>T	c.(1153-1155)cCa>cTa	p.P385L	WWP1_ENST00000341922.2_Missense_Mutation_p.P255L|WWP1_ENST00000349423.2_Missense_Mutation_p.P167L|WWP1_ENST00000265428.4_Missense_Mutation_p.P385L	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	385	WW 2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						CCTTTACCTCCAGGGTAATAT	0.338000													15	35					0	0	1	0	0
MIF4GD	57409	broad.mit.edu	37	17	73265518	73265518	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:73265518C>G	ENST00000577542.1	-	3	377	c.115G>C	c.(115-117)Gag>Cag	p.E39Q	MIF4GD_ENST00000579297.1_Missense_Mutation_p.E39Q|MIF4GD_ENST00000325102.8_Intron|MIF4GD_ENST00000245551.5_Missense_Mutation_p.E32Q|MIF4GD_ENST00000578305.1_Intron|MIF4GD_ENST00000580571.1_Intron|MIF4GD_ENST00000579119.1_Intron			A9UHW6	MI4GD_HUMAN	MIF4G domain containing	27	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)	10	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TCTTCTGTCTCAAAGCAGGCA	0.483000													26	71					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37163021	37163021	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:37163021C>T	ENST00000421307.1	-	7	714	c.292G>A	c.(292-294)Gag>Aag	p.E98K	LRRFIP2_ENST00000336686.4_Missense_Mutation_p.E98K|LRRFIP2_ENST00000421276.2_Intron|LRRFIP2_ENST00000354379.4_Intron|LRRFIP2_ENST00000396428.2_Missense_Mutation_p.E81K|LRRFIP2_ENST00000440230.1_Intron	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	98	DVL3-binding.				Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						AATGCATCCTCAACTCCCTGA	0.348000													21	37					0	0	1	0	0
FUS	2521	broad.mit.edu	37	16	31195546	31195546	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:31195546C>T	ENST00000254108.7	+	5	457	c.352C>T	c.(352-354)Cag>Tag	p.Q118*	FUS_ENST00000568685.1_Nonsense_Mutation_p.Q118*|FUS_ENST00000380244.3_Nonsense_Mutation_p.Q117*	NM_001170634.1|NM_001170937.1|NM_004960.3	NP_001164105.1|NP_001164408.1|NP_004951.1	P35637	FUS_HUMAN	fused in sarcoma	118	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/ERG(167)|FUS/DDIT3(631)|FUS/FEV(2)|FUS/ATF1(4)|FUS/CREB3L1(6)|FUS/CREB3L2(158)	breast(3)|endometrium(5)|kidney(3)|large_intestine(1)|lung(5)|prostate(3)|skin(1)|urinary_tract(1)	22		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TAGCAGTTCTCAGAGCAGCAG	0.488000			T	"""DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1"""	"""liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma"""								58	101					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10969115	10969115	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:10969115C>T	ENST00000361285.4	-	7	462	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	TPTE_ENST00000342420.5_Intron|TPTE_ENST00000298232.7_Intron|TPTE_ENST00000415664.2_Intron	NM_199261.2	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	45					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTTTAAATTCACTTGTGTGT	0.468000													26	100					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36261955	36261955	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:36261955C>G	ENST00000312917.5	+	4	374	c.235C>G	c.(235-237)Ctg>Gtg	p.L79V	PNPLA1_ENST00000388715.3_Intron|PNPLA1_ENST00000394571.2_Intron			Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	168	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						ATTTCTCACTCTGCCCCCACA	0.602000													17	34					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12241929	12241929	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:12241929C>T	ENST00000256194.4	+	9	1418	c.1130C>T	c.(1129-1131)tCa>tTa	p.S377L	MICAL2_ENST00000527546.1_Missense_Mutation_p.S377L|MICAL2_ENST00000537344.1_Missense_Mutation_p.S377L|MICAL2_ENST00000342902.5_Missense_Mutation_p.S377L|MICAL2_ENST00000379612.3_Missense_Mutation_p.S377L	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	377						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ATGTATGCCTCAGAGAACGCG	0.597000													31	62					0	0	1	0	0
RPS9	6203	broad.mit.edu	37	19	54710425	54710425	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:54710425C>T	ENST00000402367.1	+	5	527	c.412C>T	c.(412-414)Cgg>Tgg	p.R138W	RPS9_ENST00000391753.2_Intron|RPS9_ENST00000441429.1_3'UTR|RPS9_ENST00000391752.1_Intron|RPS9_ENST00000302907.4_Intron|RPS9_ENST00000391751.3_Intron			P46781	RS9_HUMAN	ribosomal protein S9	138	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome|translation regulator activity			NS(1)|breast(1)|kidney(11)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	20	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.18)		ATGCAGCCCTCGGAGGTGATG	0.592000													4	13					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151496787	151496787	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:151496787C>T	ENST00000271636.7	+	7	1487	c.1354C>T	c.(1354-1356)Ctg>Ttg	p.L452L		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	446	Glu-rich.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGAACAAGCTGAAACATGT	0.517000													19	30					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46932166	46932166	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:46932166G>T	ENST00000359759.4	+	41	5140	c.5119G>T	c.(5119-5121)Gag>Tag	p.E1707*	COL18A1_ENST00000400337.2_Nonsense_Mutation_p.E1292*|COL18A1_ENST00000355480.5_Nonsense_Mutation_p.E1472*|SLC19A1_ENST00000567670.1_Intron			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	1707	Nonhelical region 11 (NC11).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GAGCTACTGTGAGACGTGGCG	0.701000													18	7					1.55795e-14	1.60864e-14	1	1	0
SNRPA1	6627	broad.mit.edu	37	15	101827883	101827883	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:101827883G>A	ENST00000254193.6	-	4	406	c.334C>T	c.(334-336)Ctc>Ttc	p.L112F	SNRPA1_ENST00000560856.1_5'UTR	NM_003090.2	NP_003081.2	P09661	RU2A_HUMAN	small nuclear ribonucleoprotein polypeptide A'	112						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGCGATTTGAGAGATGCCAGA	0.403000													10	43					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20569211	20569211	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:20569211C>T	ENST00000399722.2	+	9	1088	c.737C>T	c.(736-738)cCt>cTt	p.P246L	RBBP8_ENST00000399725.2_Missense_Mutation_p.P246L|RBBP8_ENST00000360790.5_Missense_Mutation_p.P246L|RBBP8_ENST00000327155.5_Missense_Mutation_p.P246L	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	246					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AGCTATACCCCTGATAAGTCA	0.303000								Homologous recombination					18	41					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716782	13716782	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:13716782C>T	ENST00000609686.1	-	13	3599	c.3390G>A	c.(3388-3390)cgG>cgA	p.R1130R		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B						response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTAGAAGTCCCGTAGCCCTT	0.592000													39	49					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628282	29628282	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:29628282G>A	ENST00000278882.3	+	6	664	c.284G>A	c.(283-285)gGg>gAg	p.G95E	FRG1B_ENST00000439954.2_Missense_Mutation_p.G100E|FRG1B_ENST00000358464.4_Missense_Mutation_p.G95E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATGAAGCAGGGGACATAGAA	0.373000													4	115					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104639559	104639559	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:104639559C>T	ENST00000315264.7	+	7	1627	c.1249C>T	c.(1249-1251)Ccc>Tcc	p.P417S	KIF26A_ENST00000423312.2_Missense_Mutation_p.P556S			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	556	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GCGGGAGGACCCCGTGTGTGG	0.711000													26	46					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134349001	134349001	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:134349001C>T	ENST00000357304.4	+	14	2269	c.2214C>T	c.(2212-2214)atC>atT	p.I738I	PRRC2B_ENST00000405995.1_Silent_p.I738I|PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Silent_p.I738I	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	738							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						TGACCCCCATCGACTCACCCC	0.597000													17	21					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	132937899	132937899	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:132937899C>T	ENST00000253861.4	+	1	71	c.42C>T	c.(40-42)gtC>gtT	p.V14V	EXOC4_ENST00000393161.2_Silent_p.V14V	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	14					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GAAGCACAGTCAGCAAAAGCA	0.607000													59	80					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125470711	125470711	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:125470711C>T	ENST00000308736.2	-	2	305	c.207G>A	c.(205-207)aaG>aaA	p.K69K		NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	69							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TCAGAGGCTTCTTCTCCTTCT	0.512000													44	99					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78293122	78293122	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:78293122C>T	ENST00000319921.4	+	17	3175	c.3034C>T	c.(3034-3036)Ctc>Ttc	p.L1012F	RNF213_ENST00000456466.1_Intron|RNF213_ENST00000582970.1_Intron|RNF213_ENST00000508628.2_Intron	NM_020954.3	NP_066005.2	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGTGAACAATCTCTCCTCCTG	0.552000													53	85					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63258376	63258376	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:63258376G>A	ENST00000540857.1	-	1	263	c.131C>T	c.(130-132)tCa>tTa	p.S44L	HRASLS5_ENST00000301790.4_Missense_Mutation_p.S44L|HRASLS5_ENST00000539221.1_Missense_Mutation_p.S44L	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	44										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						GGGCACAGCTGAACGTCTGAG	0.642000													6	24					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44433831	44433831	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:44433831C>T	ENST00000372622.3	+	9	718	c.650C>T	c.(649-651)tCt>tTt	p.S217F		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	217						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				GTGTTGGGATCTCGAGCCAAC	0.463000													83	126					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58608568	58608568	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:58608568G>A	ENST00000317147.5	-	16	2256	c.1924C>T	c.(1924-1926)Caa>Taa	p.Q642*	CNOT1_ENST00000441024.2_Nonsense_Mutation_p.Q642*|CNOT1_ENST00000569240.1_Nonsense_Mutation_p.Q642*	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	642					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GGAGGAAGTTGAGCACTTTTG	0.433000													17	68					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80376426	80376426	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:80376426G>C	ENST00000265080.4	+	7	1046	c.979G>C	c.(979-981)Gat>Cat	p.D327H	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	327	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGATCTGTTTGATATTTTGCT	0.433000													33	67					0	0	1	0	0
PARVB	29780	broad.mit.edu	37	22	44489833	44489833	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:44489833G>C	ENST00000338758.7	+	2	201	c.138G>C	c.(136-138)aaG>aaC	p.K46N	PARVB_ENST00000404989.1_Missense_Mutation_p.K9N|PARVB_ENST00000477795.1_3'UTR|PARVB_ENST00000406477.3_Missense_Mutation_p.K79N	NM_013327.4	NP_037459.2	Q9HBI1	PARVB_HUMAN	parvin, beta						cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding			NS(1)|breast(1)|endometrium(3)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	25		Ovarian(80;0.0246)|all_neural(38;0.0423)				AAGAAGGCAAGAATGCCATCA	0.562000													34	69					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179321393	179321393	+	Silent	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:179321393C>A	ENST00000356834.3	-	4	607	c.570G>T	c.(568-570)ggG>ggT	p.G190G	TBC1D9B_ENST00000355235.3_Silent_p.G190G	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	190	GRAM 1.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACCTTCCTTCCCCAGCAGGA	0.647000													12	18					0.010729	0.0107819	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	79878723	79878723	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:79878723C>A	ENST00000466387.1	+	6	765	c.41C>A	c.(40-42)cCc>cAc	p.P14H	CTNNA2_ENST00000541047.1_Missense_Mutation_p.P14H|CTNNA2_ENST00000540488.1_Missense_Mutation_p.P14H|CTNNA2_ENST00000409266.1_Missense_Mutation_p.P14H|CTNNA2_ENST00000402739.4_Missense_Mutation_p.P14H|CTNNA2_ENST00000361291.4_Missense_Mutation_p.P48H|CTNNA2_ENST00000496558.1_Missense_Mutation_p.P14H			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	14					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAATGGGACCCCAAAAGTTTG	0.398000													30	43					7.11191e-15	7.34863e-15	1	1	0
SLC43A2	124935	broad.mit.edu	37	17	1496491	1496491	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:1496491G>A	ENST00000301335.5	-	6	672	c.584C>T	c.(583-585)cCa>cTa	p.P195L	SLC43A2_ENST00000571650.1_Missense_Mutation_p.P195L|SLC43A2_ENST00000412517.3_Missense_Mutation_p.P58L|SLC43A2_ENST00000382147.4_Missense_Mutation_p.P195L|SLC43A2_ENST00000574274.1_5'UTR	NM_001284498.1|NM_001284499.1	NP_001271427.1|NP_001271428.1	Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2						cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		CTTGATTCCTGGAAAGGTGAC	0.552000													8	8					0	0	1	0	0
UBXN8	7993	broad.mit.edu	37	8	30614338	30614338	+	RNA	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:30614338G>C	ENST00000519246.1	+	0	661							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						AAGCAGCAAAGAGCCAGAACT	0.413000													22	36					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111519795	111519795	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:111519795G>A	ENST00000261486.5	-	18	1816	c.1540C>T	c.(1540-1542)Cag>Tag	p.Q514*	EPB41L4A_ENST00000507810.1_5'UTR	NM_022140.3	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	514						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GCTTCCCACTGAGGCGCTGAA	0.453000													18	46					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625185	74625185	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:74625185C>T	ENST00000156626.7	-	2	939	c.740G>A	c.(739-741)aGa>aAa	p.R247K	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	247					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						TCTTTGGTTTCTCTGCGTCGT	0.532000													35	76					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82545072	82545072	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:82545072G>A	ENST00000268206.7	-	4	372	c.204C>T	c.(202-204)atC>atT	p.I68I	EFTUD1_ENST00000359445.3_Intron	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	68					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						ATTTCATAGTGATCCCTCGGA	0.383000													16	19					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1097901	1097901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:1097901C>T	ENST00000441003.2	+	36	7021	c.6994C>T	c.(6994-6996)Cag>Tag	p.Q2332*	MUC2_ENST00000361558.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4694						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TCCCCTCTGCCAGCTCATCAA	0.667000													7	10					0	0	1	0	0
PHF10	55274	broad.mit.edu	37	6	170110477	170110477	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:170110477G>A	ENST00000339209.4	-	9	1091	c.968C>T	c.(967-969)tCt>tTt	p.S323F	PHF10_ENST00000366780.4_Missense_Mutation_p.S321F	NM_018288.3|NM_133325.2	NP_060758.2|NP_579866.2	Q8WUB8	PHF10_HUMAN	PHD finger protein 10	323	Essential to induce neural progenitor proliferation (By similarity).				nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	npBAF complex	zinc ion binding			endometrium(2)|large_intestine(2)|liver(3)|lung(4)|prostate(2)|urinary_tract(1)	14		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.4e-21)|BRCA - Breast invasive adenocarcinoma(81;1.4e-07)|GBM - Glioblastoma multiforme(31;0.00176)		TACATTGCCAGAGGAGCTGTC	0.398000													31	28					0	0	1	0	0
MAP2K2	5605	broad.mit.edu	37	19	4110574	4110574	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:4110574G>A	ENST00000262948.5	-	3	636	c.383C>T	c.(382-384)cCg>cTg	p.P128L	MAP2K2_ENST00000394867.4_Missense_Mutation_p.P31L|MAP2K2_ENST00000599345.1_5'UTR	NM_030662.3	NP_109587.1	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	128	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGATGTACGGCGAGTTGCA	0.622000													39	59					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74407261	74407261	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:74407261C>G	ENST00000437994.2	+	2	644	c.213C>G	c.(211-213)gtC>gtG	p.V71V	CD109_ENST00000422508.2_Silent_p.V71V|CD109_ENST00000287097.5_Silent_p.V71V	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	71						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACCTCACTGTCTCTGTCCTGG	0.458000													36	137					0	0	1	0	0
NAA10	8260	broad.mit.edu	37	X	153199422	153199422	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:153199422C>T	ENST00000464845.1	-	3	471	c.153G>A	c.(151-153)aaG>aaA	p.K51K	NAA10_ENST00000370015.4_Silent_p.K51K|NAA10_ENST00000393710.3_5'UTR|NAA10_ENST00000370009.1_Silent_p.K51K|NAA10_ENST00000393712.3_Silent_p.K51K	NM_001256120.1|NM_003491.3	NP_001243049.1|NP_003482.1	P41227	NAA10_HUMAN	N(alpha)-acetyltransferase 10, NatA catalytic subunit	51	Interaction with NAA15.|N-acetyltransferase.				DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(3)|ovary(1)|prostate(1)	10						ACCCCACAATCTTCCCATTCT	0.468000													4	102					0	0	1	0	0
C7orf26	79034	broad.mit.edu	37	7	6639727	6639727	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:6639727C>T	ENST00000344417.5	+	4	1115	c.848C>T	c.(847-849)tCc>tTc	p.S283F	C7orf26_ENST00000472693.1_3'UTR|C7orf26_ENST00000359073.5_Intron	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	283										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		GACAGAGACTCCCACCTCTTG	0.562000													30	30					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74607200	74607200	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:74607200C>G	ENST00000253159.8	+	10	1841	c.1643C>G	c.(1642-1644)tCc>tGc	p.S548C	ZNF236_ENST00000320610.9_Missense_Mutation_p.S550C	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	548					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AAGAGCTTCTCCACCTCTGGC	0.617000													25	47					0	0	1	0	0
SERPINF1	5176	broad.mit.edu	37	17	1679943	1679943	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:1679943G>A	ENST00000254722.4	+	7	1067	c.904G>A	c.(904-906)Gac>Aac	p.D302N		NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	302					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						TCATGACATAGACCGAGAACT	0.517000													99	60					0	0	1	0	0
NUF2	83540	broad.mit.edu	37	1	163306609	163306609	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:163306609G>A	ENST00000271452.3	+	6	685	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	NUF2_ENST00000524800.1_Missense_Mutation_p.E136K|NUF2_ENST00000367900.3_Missense_Mutation_p.E136K|NUF2_ENST00000490881.1_3'UTR	NM_145697.2	NP_663735.2	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	136	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	all_hematologic(923;0.101)					AGCATGCCGTGAAACGTATAT	0.313000													5	34					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133114727	133114727	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:133114727G>A	ENST00000321871.6	+	6	1835	c.1625G>A	c.(1624-1626)cGc>cAc	p.R542H	TMEM108_ENST00000508711.1_Missense_Mutation_p.R72H|TMEM108_ENST00000393130.3_Missense_Mutation_p.R542H	NM_001136469.1|NM_023943.2	NP_001129941.1|NP_076432.1	Q6UXF1	TM108_HUMAN	transmembrane protein 108	542						integral to membrane		p.R542H(1)		endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TCAGAGCCCCGCTCCCCAGCC	0.507000													17	36					0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828631	23828631	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:23828631G>A	ENST00000216733.3	-	4	1663	c.1056C>T	c.(1054-1056)gtC>gtT	p.V352V	EFS_ENST00000351354.3_Silent_p.V259V|EFS_ENST00000429593.2_Silent_p.V183V	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	352					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GATCCCCCTCGACCTTGGGGC	0.662000													27	65					0	0	1	0	0
BLMH	642	broad.mit.edu	37	17	28601168	28601168	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:28601168G>A	ENST00000261714.6	-	7	867	c.693C>T	c.(691-693)ttC>ttT	p.F231F	BLMH_ENST00000582669.1_5'UTR|BLMH_ENST00000394819.3_Silent_p.F144F	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	231					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						ATTCCCAGGTGAATGTCTCTG	0.433000													31	76					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14037855	14037855	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:14037855G>C	ENST00000318003.7	+	21	2431	c.2190G>C	c.(2188-2190)caG>caC	p.Q730H	CC2D1A_ENST00000589606.1_Missense_Mutation_p.Q730H	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	730	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GGGCCATCCAGACCAAGGGCA	0.602000													25	43					0	0	1	0	0
EDEM3	80267	broad.mit.edu	37	1	184671965	184671965	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:184671965G>C	ENST00000318130.8	-	19	2635	c.2369C>G	c.(2368-2370)tCt>tGt	p.S790C	EDEM3_ENST00000367512.3_Missense_Mutation_p.S747C|EDEM3_ENST00000466392.1_5'UTR	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	790					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TGCTTTATCAGAGAGGAGCAC	0.368000													10	32					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99028079	99028079	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:99028079C>G	ENST00000299157.4	-	2	665	c.292G>C	c.(292-294)Gaa>Caa	p.E98Q	IKBIP_ENST00000420861.1_Intron|IKBIP_ENST00000393042.3_Intron|IKBIP_ENST00000342502.2_Missense_Mutation_p.E98Q	NM_153687.3	NP_710154.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	98					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						ATTACCTTTTCTGAAATTAAA	0.363000													12	25					0	0	1	0	0
NBPF22P	285622	broad.mit.edu	37	5	85578701	85578701	+	RNA	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:85578701G>C	ENST00000590707.1	+	0	424					NR_003719.2																						AGACCTCAAAGAGAAATTCCT	0.458000													13	37					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120591103	120591103	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:120591103G>A	ENST00000300648.6	-	33	3988	c.3976C>T	c.(3976-3978)Ctg>Ttg	p.L1326L		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1326					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCTTGGCCAGAGAGCCCATC	0.577000													19	33					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36437683	36437683	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:36437683C>T	ENST00000373191.4	+	4	720	c.371C>T	c.(370-372)tCa>tTa	p.S124L	AGO3_ENST00000397828.2_Missense_Mutation_p.S124L|AGO3_ENST00000246314.6_5'UTR|AGO3_ENST00000324350.5_Missense_Mutation_p.S124L	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		TTCAAGGTGTCAATCAAATTT	0.448000													12	21					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2405465	2405465	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:2405465G>A	ENST00000332578.3	+	6	662	c.662G>A	c.(661-663)cGa>cAa	p.R221Q		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	221	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCCTTCGAGAGAACAAG	0.617000													40	89					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61811326	61811326	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:61811326C>T	ENST00000325324.6	+	20	2063	c.1894C>T	c.(1894-1896)Cag>Tag	p.Q632*	IPO11_ENST00000409296.3_Nonsense_Mutation_p.Q672*|KIF2A_ENST00000509663.2_3'UTR	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	632						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TCATCTTGTTCAGGTAAGTCA	0.313000													25	46					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27944561	27944561	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:27944561C>T	ENST00000345068.5	-	6	923	c.710G>A	c.(709-711)gGc>gAc	p.G237D	CORO6_ENST00000445145.2_Intron|CORO6_ENST00000580212.1_Intron|CORO6_ENST00000577909.1_Intron|CORO6_ENST00000456796.3_Intron|CORO6_ENST00000584969.1_Intron|CORO6_ENST00000388767.3_Missense_Mutation_p.G237D|RP11-68I3.2_ENST00000581474.1_RNA			Q6QEF8	CORO6_HUMAN	coronin 6	237					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						GCGGGTGAAGCCCGTGGTGAA	0.682000													16	31					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34922529	34922529	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:34922529C>T	ENST00000356577.4	+	3	1467	c.992C>T	c.(991-993)tCa>tTa	p.S331L	SON_ENST00000381679.4_Missense_Mutation_p.S331L|SON_ENST00000300278.4_Missense_Mutation_p.S331L|SON_ENST00000381692.2_Intron|SON_ENST00000290239.6_Missense_Mutation_p.S331L	NM_138927.1	NP_620305	P18583	SON_HUMAN	SON DNA binding protein	331					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TTTCCAGAGTCATCTGCAATT	0.488000											OREG0003564	type=REGULATORY REGION|Gene=AK074269|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	38	52					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62931484	62931484	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:62931484C>T	ENST00000393630.3	+	16	2507	c.2116C>T	c.(2116-2118)Cag>Tag	p.Q706*	MON2_ENST00000393629.2_Nonsense_Mutation_p.Q706*|MON2_ENST00000552115.1_Nonsense_Mutation_p.Q706*|MON2_ENST00000393632.2_Nonsense_Mutation_p.Q706*|MON2_ENST00000546600.1_Nonsense_Mutation_p.Q706*|MON2_ENST00000280379.6_Nonsense_Mutation_p.Q706*|MON2_ENST00000552738.1_Nonsense_Mutation_p.Q683*	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	706					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		GGCAACTCTTCAGGTATGTAA	0.383000													28	54					0	0	1	0	0
TBRG4	9238	broad.mit.edu	37	7	45140930	45140930	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:45140930C>T	ENST00000258770.3	-	10	1842	c.1721G>A	c.(1720-1722)cGa>cAa	p.R574Q	TBRG4_ENST00000494076.1_Missense_Mutation_p.R574Q|TBRG4_ENST00000395655.4_Missense_Mutation_p.R464Q|TBRG4_ENST00000361278.3_Missense_Mutation_p.R464Q	NM_004749.3	NP_004740.2	Q969Z0	TBRG4_HUMAN	transforming growth factor beta regulator 4	574	RAP.				apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity	p.R574L(1)		cervix(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(2)	17						GTCCTTGCTTCGGCTGTTGAA	0.587000													40	50					0	0	1	0	0
TCF19	6941	broad.mit.edu	37	6	31127453	31127453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31127453G>A	ENST00000376257.3	+	2	961	c.207G>A	c.(205-207)tgG>tgA	p.W69*	TCF19_ENST00000376255.4_Nonsense_Mutation_p.W69*	NM_007109.2	NP_009040.2	Q9Y242	TCF19_HUMAN	transcription factor 19	69	FHA.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						GTGATGACTGGAGGGTCAGCC	0.642000													18	32					0	0	1	0	0
XYLB	9942	broad.mit.edu	37	3	38437034	38437034	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:38437034C>T	ENST00000207870.3	+	16	1420	c.1330C>T	c.(1330-1332)Cac>Tac	p.H444Y	XYLB_ENST00000542835.1_Missense_Mutation_p.H307Y|XYLB_ENST00000472721.1_3'UTR	NM_005108.3	NP_005099.2	O75191	XYLB_HUMAN	xylulokinase homolog (H. influenzae)	444					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			endometrium(3)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|prostate(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		AGGAGCATCTCACAATAGAGA	0.453000													15	28					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2696719	2696719	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:2696719C>T	ENST00000324666.5	+	15	2617	c.2266C>T	c.(2266-2268)Cca>Tca	p.P756S	FAM193A_ENST00000545951.1_Missense_Mutation_p.P756S|FAM193A_ENST00000502458.1_Missense_Mutation_p.P778S|FAM193A_ENST00000505311.1_Missense_Mutation_p.P756S|FAM193A_ENST00000382839.3_Missense_Mutation_p.P756S	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	756										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TGTCTACGACCCACAGCAGGA	0.597000													5	25					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476226	17476226	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:17476226C>T	ENST00000252590.4	-	3	1109	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	350						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ACCGCCTTCTCCTCCAGCGCT	0.622000													37	90					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058659	9058659	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:9058659G>A	ENST00000397910.4	-	3	28990	c.28787C>T	c.(28786-28788)tCa>tTa	p.S9596L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9598	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTGTGGATGAGGTGATGTC	0.517000													26	28					0	0	1	0	0
C1ORF220	400798	broad.mit.edu	37	1	178514972	178514972	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:178514972C>G	ENST00000367636.4	+	2	696	c.358C>G	c.(358-360)Cat>Gat	p.H120D	C1orf220_ENST00000521244.1_3'UTR|C1orf220_ENST00000319387.2_3'UTR																							ATTATCATTTCATGCCCTAAA	0.428000													17	27					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47344438	47344438	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:47344438C>T	ENST00000398879.1	-	21	3180	c.2814G>A	c.(2812-2814)agG>agA	p.R938R	TNS3_ENST00000355730.3_Silent_p.R698R|TNS3_ENST00000311160.9_Silent_p.R938R			Q68CZ2	TENS3_HUMAN	tensin 3	938						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						ACCTCTCTCTCCTCTGCCCAG	0.552000													21	22					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080076	23080076	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:23080076G>A	ENST00000219689.7	-	16	3349	c.3350C>T	c.(3349-3351)tCa>tTa	p.S1117L	USP31_ENST00000567975.1_Missense_Mutation_p.S410L	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1117	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GGCCGAGGCTGACTTCTGCTT	0.587000													24	111					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10220901	10220901	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10220901G>C	ENST00000428358.1	+	8	973	c.801G>C	c.(799-801)caG>caC	p.Q267H	PPAN_ENST00000253107.7_Missense_Mutation_p.Q267H|PPAN_ENST00000556468.1_Missense_Mutation_p.Q267H|PPAN_ENST00000393793.1_Missense_Mutation_p.Q214H|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.Q267H	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		267	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GGGCCCAGCAGAGTGCAGTGC	0.692000													10	31					0	0	1	0	0
DGCR6	8214	broad.mit.edu	37	22	18893891	18893891	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:18893891G>A	ENST00000608842.1	+	1	26	c.4G>A	c.(4-6)Gag>Aag	p.E2K	DGCR6_ENST00000413981.1_Intron|DGCR6_ENST00000331444.6_Missense_Mutation_p.E2K			Q14129	DGCR6_HUMAN	DiGeorge syndrome critical region gene 6					MERYAGALEEVA -> PKGAKAGYQPRG (in Ref. 3).	cell adhesion|organ morphogenesis	nucleus|proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|upper_aerodigestive_tract(1)	3						CCGCGCCATGGAGCGCTACGC	0.701000													4	6					0	0	1	0	0
ZNF664	144348	broad.mit.edu	37	12	124497235	124497235	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:124497235C>T	ENST00000539644.1	+	6	2374	c.544C>T	c.(544-546)Cag>Tag	p.Q182*	FAM101A_ENST00000545615.1_Intron|ZNF664_ENST00000538932.2_Nonsense_Mutation_p.Q182*|ZNF664_ENST00000337815.4_Nonsense_Mutation_p.Q182*|ZNF664_ENST00000392404.3_Nonsense_Mutation_p.Q182*			Q8N3J9	ZN664_HUMAN	zinc finger protein 664	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(5)|lung(6)|skin(1)	13	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		GGCGTTCAGTCAGAGTTCGAG	0.522000													35	122					0	0	1	0	0
MESP2	145873	broad.mit.edu	37	15	90321314	90321314	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:90321314G>A	ENST00000341735.3	+	2	943	c.943G>A	c.(943-945)Gag>Aag	p.E315K	MESP2_ENST00000560219.1_Missense_Mutation_p.E17K|MESP2_ENST00000558723.1_3'UTR	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	315					Notch signaling pathway	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TGTGTCTCCAGAGCCCTGTCT	0.587000													7	38					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213302993	213302993	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:213302993C>T	ENST00000366960.3	+	6	746	c.596C>T	c.(595-597)tCg>tTg	p.S199L	RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543354.1_Intron|RPS6KC1_ENST00000366959.3_Missense_Mutation_p.S187L|RPS6KC1_ENST00000543470.1_Missense_Mutation_p.S18L	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	199					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AATCTTTCTTCGGATTCTTCA	0.433000													25	24					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137622921	137622921	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:137622921C>T	ENST00000323760.6	-	11	1241	c.963G>A	c.(961-963)ctG>ctA	p.L321L	CDC25C_ENST00000357274.3_Silent_p.L278L|CDC25C_ENST00000348983.3_Silent_p.L248L|CDC25C_ENST00000415130.2_Silent_p.L248L|CDC25C_ENST00000513970.1_Silent_p.L321L|CDC25C_ENST00000356505.3_Silent_p.L291L|CDC25C_ENST00000514555.1_Silent_p.L291L	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	321	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACTTCTCAATCAGACCCTGGA	0.493000													25	58					0	0	1	0	0
H3F3B	3021	broad.mit.edu	37	17	73775041	73775041	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:73775041G>A	ENST00000254810.4	-	3	264	c.132C>T	c.(130-132)ccC>ccT	p.P44P	H3F3B_ENST00000591890.1_Silent_p.P44P|H3F3B_ENST00000589599.1_Silent_p.P44P|H3F3B_ENST00000593254.1_Intron|H3F3B_ENST00000587560.1_Silent_p.P44P|H3F3B_ENST00000592643.1_Silent_p.P44P|H3F3B_ENST00000586607.1_Silent_p.P44P	NM_005324.3	NP_005315.1	P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	44					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCACGGTCCCGGGCCTGCAGC	0.662000											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	56					0	0	1	0	0
CRABP2	1382	broad.mit.edu	37	1	156670374	156670374	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:156670374G>A	ENST00000368222.3	-	3	480	c.326C>T	c.(325-327)tCg>tTg	p.S109L	CRABP2_ENST00000368221.1_Missense_Mutation_p.S109L	NM_001199723.1|NM_001878.3	NP_001186652.1|NP_001869.1	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	109					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			endometrium(2)|lung(3)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	TCTGGTCCACGAGGTCTTGGG	0.537000													10	58					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:37868208C>T	ENST00000406381.2	+	10	1349	c.839C>T	c.(838-840)tCc>tTc	p.S280F	ERBB2_ENST00000578199.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584601.1_Missense_Mutation_p.S280F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S280F|ERBB2_ENST00000445658.2_Missense_Mutation_p.S34F|ERBB2_ENST00000541774.1_Missense_Mutation_p.S295F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S280F|ERBB2_ENST00000269571.5_Missense_Mutation_p.S310F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S310F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	310					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(6)|p.S310Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			90	198					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226589954	226589954	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:226589954G>A	ENST00000366794.5	-	2	390	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	PARP1_ENST00000366792.1_Nonsense_Mutation_p.Q83*|PARP1_ENST00000366790.3_Nonsense_Mutation_p.Q83*|PARP1_ENST00000366791.5_Nonsense_Mutation_p.Q83*	NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	83					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TTGACTTTCTGCTGGTCATCC	0.592000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					14	65					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115537623	115537623	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:115537623G>A	ENST00000369522.3	+	32	3154	c.2914G>A	c.(2914-2916)Gaa>Aaa	p.E972K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E972K|SYCP1_ENST00000477590.1_3'UTR	NM_001282541.1|NM_003176.2	NP_001269470.1|NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	972					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAAGAAGCTGAAAAGTTATT	0.338000													9	51					0	0	1	0	0
SRSF9	8683	broad.mit.edu	37	12	120907260	120907260	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:120907260G>A	ENST00000229390.3	-	1	336	c.153C>T	c.(151-153)ctC>ctT	p.L51L		NM_003769.2	NP_003760.1	Q13242	SRSF9_HUMAN	serine/arginine-rich splicing factor 9	51	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	9						CGAAGGGCACGAGGCCGTGCC	0.687000													18	41					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41865997	41865997	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:41865997G>A	ENST00000263798.3	+	18	2490	c.2266G>A	c.(2266-2268)Gag>Aag	p.E756K	TYRO3_ENST00000559066.1_Missense_Mutation_p.E711K	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	756	Protein kinase.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.E756Q(2)|p.E748Q(2)		central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		ACAGCCTCCGGAGTGTATGGA	0.552000													37	36					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	153					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28872291	28872291	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:28872291G>A	ENST00000377199.3	-	8	1454	c.1098C>T	c.(1096-1098)ttC>ttT	p.F366F	TRIM27_ENST00000377194.3_Intron	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	366	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						TCCCGGCGATGAAGCATGGAG	0.517000			T	RET	papillary thyroid								6	43					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47896810	47896810	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:47896810G>A	ENST00000426837.2	-	19	6711	c.6624C>T	c.(6622-6624)ttC>ttT	p.F2208F	MAP4_ENST00000264724.11_Silent_p.F798F|MAP4_ENST00000360240.6_Silent_p.F1063F|MAP4_ENST00000383737.4_Silent_p.F722F|MAP4_ENST00000420772.2_Silent_p.F756F|MAP4_ENST00000395734.3_Silent_p.F1063F|MAP4_ENST00000441748.2_Silent_p.F177F			P27816	MAP4_HUMAN	microtubule-associated protein 4	1063					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CCTTCTCCTTGAAGTTCAACT	0.542000													34	79					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128466262	128466262	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:128466262C>T	ENST00000322313.4	-	21	3928	c.3770G>A	c.(3769-3771)cGa>cAa	p.R1257Q		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1257					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TTTGCCTCCTCGGTCTTCAGA	0.612000													92	65					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31856826	31856826	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:31856826G>A	ENST00000395728.3	-	9	1306	c.1307C>T	c.(1306-1308)tCa>tTa	p.S436L	EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375528.4_Intron|EHMT2_ENST00000375537.4_Missense_Mutation_p.S379L|EHMT2_ENST00000375530.4_Intron			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	379					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						ACTGGGGCCTGAGGAGCCCAC	0.622000													7	6					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179095626	179095626	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:179095626G>A	ENST00000502732.1	-	4	776	c.573C>T	c.(571-573)atC>atT	p.I191I	ABL2_ENST00000512653.1_Silent_p.I176I|ABL2_ENST00000344730.3_Silent_p.I176I|ABL2_ENST00000392043.3_Silent_p.I170I|ABL2_ENST00000507173.1_Silent_p.I170I|ABL2_ENST00000511413.1_Silent_p.I191I|ABL2_ENST00000504405.1_Silent_p.I155I|ABL2_ENST00000408940.3_Silent_p.I155I|ABL2_ENST00000367623.4_Silent_p.I170I	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	191	SH2.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AGCTGCCATTGATTAGACTGC	0.527000			T	ETV6	AML								21	65					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120591172	120591172	+	Silent	SNP	G	G	A	rs11609206		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:120591172G>A	ENST00000300648.6	-	33	3919	c.3907C>T	c.(3907-3909)Ctg>Ttg	p.L1303L		NM_006836.1	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1303					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGTTCTTCAGGAACTCCTCG	0.562000													12	23					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44893819	44893819	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:44893819C>T	ENST00000326047.4	+	34	4241	c.4092C>T	c.(4090-4092)gtC>gtT	p.V1364V	KIF15_ENST00000425755.1_Silent_p.V999V	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	1364					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AGGAAAATGTCAGGCTTGCTG	0.333000													18	48					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186291451	186291451	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:186291451G>A	ENST00000367478.4	-	45	6756	c.6460C>T	c.(6460-6462)Cat>Tat	p.H2154Y		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTAACTTACTGAATTGCTTCA	0.333000			T	NTRK1	papillary thyroid								5	12					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7852456	7852456	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:7852456G>A	ENST00000380262.3	+	18	3558	c.2633G>A	c.(2632-2634)gGt>gAt	p.G878D	CNTROB_ENST00000380255.3_3'UTR|CNTROB_ENST00000565740.1_Missense_Mutation_p.G857D|CNTROB_ENST00000563694.1_Missense_Mutation_p.G856D	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	856	Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				TCCCGCTTGGGTGAGATCCCC	0.587000													47	26					0	0	1	0	0
DNAJB14	79982	broad.mit.edu	37	4	100844301	100844301	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:100844301G>A	ENST00000442697.2	-	3	501	c.347C>T	c.(346-348)aCg>aTg	p.T116M		NM_001031723.2|NM_001278310.1	NP_001026893.1|NP_001265239.1	Q8TBM8	DJB14_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 14	116	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)		AGCATCTTTCGTAACTCCAAG	0.343000													5	5					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77684101	77684101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:77684101C>T	ENST00000461745.1	+	24	4741	c.3841C>T	c.(3841-3843)Caa>Taa	p.Q1281*	ROBO2_ENST00000332191.8_Nonsense_Mutation_p.Q1342*|ROBO2_ENST00000487694.3_Nonsense_Mutation_p.Q1297*	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1281					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGCCCTGAGTCAAAGTCAGAG	0.488000													37	77					0	0	1	0	0
GTF2F2	2963	broad.mit.edu	37	13	45827023	45827023	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:45827023C>G	ENST00000340473.6	+	6	545	c.404C>G	c.(403-405)tCt>tGt	p.S135C	GTF2F2_ENST00000494087.1_3'UTR	NM_004128.2	NP_004119.1	P13984	T2FB_HUMAN	general transcription factor IIF, polypeptide 2, 30kDa	135					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	microtubule cytoskeleton|transcription factor TFIIF complex	ATP binding|ATP-dependent helicase activity|DNA binding|protein binding			breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|prostate(1)|upper_aerodigestive_tract(1)	10		Lung NSC(96;0.00115)|Prostate(109;0.00578)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000647)		ATAGAAGAGTCTTCCAAACCA	0.323000													16	16					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95602959	95602959	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:95602959G>C	ENST00000343958.4	-	2	2324	c.2101C>G	c.(2101-2103)Caa>Gaa	p.Q701E	FGD6_ENST00000549499.1_Missense_Mutation_p.Q701E|FGD6_ENST00000546711.1_Missense_Mutation_p.Q701E	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	701					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						CTCTTCTTTTGAGATTCCAGG	0.478000													4	183					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52876709	52876709	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:52876709C>T	ENST00000356971.3	-	12	1839	c.1350G>A	c.(1348-1350)gaG>gaA	p.E450E	ICK_ENST00000350082.5_Silent_p.E450E	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	450					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					CCAAAACACTCTCAAACCTGA	0.517000													9	89					0	0	1	0	0
TRAV8-7	28679	broad.mit.edu	37	14	22600808	22600808	+	RNA	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:22600808C>T	ENST00000390456.3	+	0	153																											CTTCTCTCTTCTGGTATGTCC	0.493000													15	40					0	0	1	0	0
C16orf58	64755	broad.mit.edu	37	16	31503346	31503346	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:31503346G>A	ENST00000327237.2	-	12	1332	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	C16orf58_ENST00000570164.1_Silent_p.F429F|C16orf58_ENST00000567994.1_Silent_p.F386F			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	431						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						AGAACTTTGGGAACAGCATGT	0.587000													4	30					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103804704	103804704	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:103804704G>A	ENST00000216554.3	+	7	1156	c.480G>A	c.(478-480)aaG>aaA	p.K160K	EIF5_ENST00000392715.2_Silent_p.K160K|EIF5_ENST00000558506.1_Silent_p.K160K	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	160					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			aaaaagaaaagaaaaacagaa	0.393000													16	41					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212254019	212254019	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:212254019G>C	ENST00000366991.4	+	13	1502	c.1188G>C	c.(1186-1188)gaG>gaC	p.E396D	DTL_ENST00000475419.1_3'UTR|DTL_ENST00000542077.1_Missense_Mutation_p.E354D	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	396					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		GCTTAGAGGAGAAACCAGGAG	0.418000													78	74					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118484889	118484889	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:118484889G>C	ENST00000311085.8	+	18	3447	c.3367G>C	c.(3367-3369)Gac>Cac	p.D1123H	DMXL1_ENST00000539542.1_Missense_Mutation_p.D1123H	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1123										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TAATAAACAAGACATGTATTT	0.353000													43	89					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96949491	96949491	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:96949491G>C	ENST00000267584.4	+	16	1953	c.1909G>C	c.(1909-1911)Gaa>Caa	p.E637Q		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	637	Glu-rich.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity	p.E637K(1)		breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GGCTGCTGAGGAAGCAGAACG	0.567000													14	28					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112318791	112318791	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:112318791C>G	ENST00000369697.1	-	6	1888	c.1819G>C	c.(1819-1821)Gag>Cag	p.E607Q	KCND3_ENST00000315987.2_Missense_Mutation_p.E626Q|KCND3_ENST00000302127.4_Missense_Mutation_p.E607Q			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	626						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CTTTCCCCCTCTGGGGTTAGC	0.557000													23	69					0	0	1	0	0
DTX2	113878	broad.mit.edu	37	7	76126698	76126698	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:76126698C>T	ENST00000324432.5	+	7	1564	c.1054C>T	c.(1054-1056)Ctt>Ttt	p.L352F	DTX2_ENST00000413936.2_Missense_Mutation_p.L352F|DTX2_ENST00000446600.1_Missense_Mutation_p.L261F|DTX2_ENST00000430490.2_Missense_Mutation_p.L352F|DTX2_ENST00000446820.2_Intron|DTX2_ENST00000307569.8_Intron	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	352					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						CCCTGTGTGTCTTAGCCGCGC	0.562000													16	166					0	0	1	0	0
HOMER3	9454	broad.mit.edu	37	19	19049694	19049694	+	Splice_Site	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:19049694C>T	ENST00000539827.1	-	2	667		c.e2-1		HOMER3_ENST00000433218.2_Splice_Site|HOMER3_ENST00000542541.2_Splice_Site|HOMER3_ENST00000355887.6_Splice_Site|HOMER3_ENST00000392351.3_Splice_Site|HOMER3_ENST00000594439.1_Splice_Site|HOMER3_ENST00000221222.11_Splice_Site|HOMER3_ENST00000594794.1_Intron			Q9NSC5	HOME3_HUMAN	homer homolog 3 (Drosophila)						metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding			endometrium(3)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10			Epithelial(12;0.0107)			TGGCTGCTCCCTGCGTGGGGA	0.632000													4	11					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	70999456	70999456	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:70999456C>T	ENST00000396396.1	+	3	796	c.567C>T	c.(565-567)ttC>ttT	p.F189F	PGM5_ENST00000604870.2_3'UTR|PGM5_ENST00000396392.1_Silent_p.F189F	NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	189					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						TCAAACCATTCAGAGGTAACA	0.378000													24	41					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151921149	151921149	+	Nonsense_Mutation	SNP	G	G	A	rs4024370		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:151921149G>A	ENST00000355193.2	-	20	3492	c.3274C>T	c.(3274-3276)Cga>Tga	p.R1092*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.R1092*					lysine (K)-specific methyltransferase 2C																		CTATAGTTTCGATAGCAGACT	0.388000													5	64					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103434682	103434682	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:103434682C>G	ENST00000361246.2	-	16	2542	c.2254G>C	c.(2254-2256)Gag>Cag	p.E752Q		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	752					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		ACTGCCTCCTCCATCTCGTTA	0.398000													30	89					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33716513	33716513	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:33716513G>A	ENST00000253188.4	-	1	243	c.97C>T	c.(97-99)Cgg>Tgg	p.R33W		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					AGCGCCACCCGCTCCGAGGCG	0.751000													8	20					0	0	1	0	0
SH3GLB2	56904	broad.mit.edu	37	9	131770969	131770969	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:131770969G>A	ENST00000372564.3	-	11	1327	c.1182C>T	c.(1180-1182)ctC>ctT	p.L394L	SH3GLB2_ENST00000416629.1_Silent_p.L373L|SH3GLB2_ENST00000417224.1_Silent_p.L399L|SH3GLB2_ENST00000372559.1_Silent_p.L394L|SH3GLB2_ENST00000372554.4_Silent_p.L403L	NM_020145.2	NP_064530.1	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	394	SH3.				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding			NS(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)	12						CTGCCTAGCTGAGCAGTTCCA	0.582000											OREG0003926	type=REGULATORY REGION|Gene=SH3GLB2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	25					0	0	1	0	0
CCNO	10309	broad.mit.edu	37	5	54528315	54528315	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:54528315G>A	ENST00000282572.4	-	2	597	c.441C>T	c.(439-441)ttC>ttT	p.F147F		NM_021147.3	NP_066970.3	P22674	CCNO_HUMAN	cyclin O	147					cell cycle|cell division|depyrimidination|regulation of cyclin-dependent protein kinase activity	nucleoplasm	protein kinase binding|uracil DNA N-glycosylase activity			endometrium(1)|lung(3)|skin(1)	5		Lung NSC(810;4.08e-05)|Breast(144;0.0735)|Prostate(74;0.183)	LUSC - Lung squamous cell carcinoma(15;0.142)|Lung(15;0.161)			AGGAGAGGCCGAATTGGCGGT	0.667000													45	66					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112219576	112219576	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:112219576G>A	ENST00000374541.2	-	3	346	c.242C>T	c.(241-243)tCt>tTt	p.S81F	PTPN3_ENST00000262539.3_5'UTR	NM_001145368.1|NM_002829.3	NP_001138840.1|NP_002820.3	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	81	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						ACTTACAGGAGAGTCCACGGA	0.428000													23	44					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1055909	1055909	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:1055909G>C	ENST00000263094.6	+	31	4440	c.4209G>C	c.(4207-4209)ctG>ctC	p.L1403L	ABCA7_ENST00000433129.1_Silent_p.L1403L|ABCA7_ENST00000435683.2_Silent_p.L1265L	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1403					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCACAGCCTGAAGACTAAGA	0.587000													24	52					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38682252	38682252	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:38682252C>T	ENST00000261438.5	+	2	311	c.6C>T	c.(4-6)ctC>ctT	p.L2L	KLF3_ENST00000514033.1_Silent_p.L2L	NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	2	Pro-rich.|Repressor domain.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						AAAGAATGCTCATGTTTGACC	0.408000													60	118					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334743	56334743	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:56334743G>C	ENST00000331886.5	+	13	1534	c.1080G>C	c.(1078-1080)ttG>ttC	p.L360F	DGKA_ENST00000551156.1_Missense_Mutation_p.L360F|DGKA_ENST00000394147.1_Missense_Mutation_p.L360F|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	360					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	ATTTAAATTTGAGCACCTCTG	0.507000													9	19					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43924454	43924454	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:43924454C>T	ENST00000282406.4	+	7	757	c.647C>T	c.(646-648)tCa>tTa	p.S216L		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	216						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCAAGATATCATCGAAAGAA	0.413000													13	54					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	377195	377195	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:377195C>T	ENST00000432829.2	+	20	2536	c.2220C>T	c.(2218-2220)gtC>gtT	p.V740V	DOCK8_ENST00000382331.1_Silent_p.V110V|DOCK8_ENST00000453981.1_Silent_p.V808V|DOCK8_ENST00000382329.1_Silent_p.V275V|DOCK8_ENST00000469391.1_Silent_p.V740V	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	808					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGCCCATGGTCATCGCTGGCC	0.567000													4	17					0	0	1	0	0
RBM48	84060	broad.mit.edu	37	7	92158209	92158209	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:92158209C>T	ENST00000481551.1	+	1	123	c.82C>T	c.(82-84)Cga>Tga	p.R28*	RBM48_ENST00000265732.5_Nonsense_Mutation_p.R28*			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	28							nucleotide binding										GGCCAAATATCGAGAGGGACG	0.542000													7	38					0	0	1	0	0
S100PBP	64766	broad.mit.edu	37	1	33291961	33291961	+	Silent	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:33291961G>C	ENST00000373475.5	+	3	515	c.261G>C	c.(259-261)ggG>ggC	p.G87G	S100PBP_ENST00000398243.3_Silent_p.G87G|S100PBP_ENST00000373476.1_Silent_p.G87G|S100PBP_ENST00000356689.3_3'UTR	NM_022753.3	NP_073590.2	Q96BU1	S1PBP_HUMAN	S100P binding protein	87						nucleus	calcium-dependent protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|stomach(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GAGAAAGAGGGAGTCAAATTC	0.468000													34	28					0	0	1	0	0
JUNB	3726	broad.mit.edu	37	19	12902735	12902735	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:12902735C>T	ENST00000302754.4	+	1	426	c.150C>T	c.(148-150)ctC>ctT	p.L50L		NM_002229.2	NP_002220.1	P17275	JUNB_HUMAN	jun B proto-oncogene	50						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|kidney(1)|lung(3)	6						ACCGGAGTCTCAAAGCGCCTG	0.677000													7	19					0	0	1	0	0
UBXN2A	165324	broad.mit.edu	37	2	24205879	24205879	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:24205879C>T	ENST00000309033.4	+	5	645	c.401C>T	c.(400-402)tCa>tTa	p.S134L	UBXN2A_ENST00000535786.1_Missense_Mutation_p.S134L|UBXN2A_ENST00000446425.2_3'UTR|UBXN2A_ENST00000404924.1_Missense_Mutation_p.S134L	NM_181713.3	NP_859064.2	P68543	UBX2A_HUMAN	UBX domain protein 2A	134										endometrium(1)|large_intestine(3)|liver(1)|lung(6)	11						CAGCCCTTTTCAGGACAGGGT	0.368000													31	36					0	0	1	0	0
NUP50	10762	broad.mit.edu	37	22	45574610	45574610	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:45574610G>A	ENST00000347635.4	+	5	1298	c.832G>A	c.(832-834)Gat>Aat	p.D278N	NUP50_ENST00000425733.2_Missense_Mutation_p.D28N|NUP50_ENST00000396096.2_Missense_Mutation_p.D250N|NUP50_ENST00000407019.2_Missense_Mutation_p.D250N	NM_007172.3	NP_009103.2	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa		5 X 2 AA repeats of F-G.|Ser-rich.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CAAGAAAGTTGATAGCTCTGT	0.443000													13	21					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103803037	103803037	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:103803037G>T	ENST00000216554.3	+	5	854	c.178G>T	c.(178-180)Gag>Tag	p.E60*	EIF5_ENST00000392715.2_Nonsense_Mutation_p.E60*|EIF5_ENST00000560200.1_3'UTR|EIF5_ENST00000558506.1_Nonsense_Mutation_p.E60*	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	60				E -> G (in Ref. 2; CAB45711).	regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			TTTTGGTTGTGAGCTGGGAGC	0.408000													21	42					2.39556e-15	2.47889e-15	1	1	0
IRF9	10379	broad.mit.edu	37	14	24624860	24624860	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:24624860C>T	ENST00000558468.1	+	6	877	c.877C>T	c.(877-879)Ccc>Tcc	p.P293S	RNF31_ENST00000324103.6_Missense_Mutation_p.P818S|RNF31_ENST00000382687.3_Missense_Mutation_p.P667S|RNF31_ENST00000559275.1_Missense_Mutation_p.P667S																							GGCAACTTGTCCCCAGTGTCA	0.517000													20	115					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21971663	21971663	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr14:21971663G>A	ENST00000298717.4	-	3	527	c.376C>T	c.(376-378)Cag>Tag	p.Q126*	METTL3_ENST00000538267.1_Nonsense_Mutation_p.Q126*	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	126					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		ATCAACTCCTGAGCTGCAAAC	0.512000													31	54					0	0	1	0	0
FEM1B	10116	broad.mit.edu	37	15	68582015	68582015	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:68582015C>G	ENST00000306917.4	+	2	934	c.319C>G	c.(319-321)Cta>Gta	p.L107V		NM_015322.4	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	107					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						TGTTAAACTTCTAGTCAGCCA	0.448000													7	28					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88584332	88584332	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:88584332G>C	ENST00000266712.6	+	12	1859	c.1639G>C	c.(1639-1641)Gaa>Caa	p.E547Q		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	547						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						CCGACTGGAAGAAGCAGATCA	0.438000													27	54					0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	44981097	44981097	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:44981097G>A	ENST00000221327.4	-	5	1882	c.1601C>T	c.(1600-1602)tCt>tTt	p.S534F	ZNF180_ENST00000391956.4_Missense_Mutation_p.S509F|ZNF180_ENST00000592529.1_Missense_Mutation_p.S507F	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	534					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				AACAAGCTGAGAGCTCCAGCT	0.403000													22	50					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17628990	17628990	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:17628990G>A	ENST00000262077.2	-	18	3439	c.3440C>T	c.(3439-3441)tCa>tTa	p.S1147L	NUP153_ENST00000537253.1_Missense_Mutation_p.S1178L	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	1147					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TGTGGACTTTGAAGAATTCTC	0.398000													16	42					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25472115	25472115	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:25472115C>T	ENST00000278886.6	-	11	1430	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	NINL_ENST00000422516.1_Missense_Mutation_p.E453K	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	453					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GCCTCCACCTCAGACCGCAGG	0.657000													5	139					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149803478	149803478	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:149803478G>C	ENST00000435030.1	+	8	1023	c.655G>C	c.(655-657)Gag>Cag	p.E219Q	KIF5C_ENST00000414838.2_Missense_Mutation_p.E124Q			O60282	KIF5C_HUMAN	kinesin family member 5C	219	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		AGAGAATGTAGAGACTGAAAA	0.323000													9	6					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	128796359	128796359	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:128796359C>G	ENST00000280333.6	+	8	722	c.613C>G	c.(613-615)Caa>Gaa	p.Q205E		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	205					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TACACAGTCTCAAAAGCAGAA	0.388000													13	11					0	0	1	0	0
SCARF2	91179	broad.mit.edu	37	22	20783871	20783871	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:20783871G>A	ENST00000405555.3	-	8	1446	c.1376C>T	c.(1375-1377)tCg>tTg	p.S459L	SCARF2_ENST00000266214.5_Missense_Mutation_p.S459L	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	459					cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCGAGCAGCGAGAGCAGCAG	0.687000													18	52					0	0	1	0	0
VAMP1	6843	broad.mit.edu	37	12	6575146	6575146	+	Silent	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:6575146C>G	ENST00000361716.3	-	3	605	c.150G>C	c.(148-150)gtG>gtC	p.V50V	VAMP1_ENST00000544432.1_5'UTR|VAMP1_ENST00000400911.3_Silent_p.V50V|VAMP1_ENST00000396308.3_Silent_p.V50V|TAPBPL_ENST00000545700.1_3'UTR|VAMP1_ENST00000535180.1_Silent_p.V50V			P23763	VAMP1_HUMAN	vesicle-associated membrane protein 1 (synaptobrevin 1)	50	v-SNARE coiled-coil homology.				neurotransmitter secretion|vesicle-mediated transport	cell junction|endocytic vesicle membrane|integral to plasma membrane|mitochondrial outer membrane|synaptic vesicle membrane|synaptosome	protein binding			endometrium(1)|large_intestine(1)|prostate(1)	3					Botulinum Toxin Type B(DB00042)	TGTCCACGTTCACACGTATGA	0.532000											OREG0021627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	49					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41025165	41025165	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:41025165C>G	ENST00000324545.8	+	16	2659	c.2026C>G	c.(2026-2028)Cag>Gag	p.Q676E	USP9X_ENST00000378308.2_Missense_Mutation_p.Q676E	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						ATGTGCTCCTCAGGCAAAACA	0.373000													22	15					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17697673	17697673	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:17697673G>A	ENST00000399080.2	-	1	2033	c.2010C>T	c.(2008-2010)ttC>ttT	p.F670F		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	670										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTGTCATACTGAAGGAATTAA	0.269000													3	29					0	0	1	0	0
ELP2	55250	broad.mit.edu	37	18	33744582	33744582	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr18:33744582C>T	ENST00000358232.6	+	18	1969	c.1906C>T	c.(1906-1908)Cga>Tga	p.R636*	ELP2_ENST00000351393.6_Nonsense_Mutation_p.R610*|ELP2_ENST00000542050.1_3'UTR|ELP2_ENST00000442325.2_Nonsense_Mutation_p.R701*|ELP2_ENST00000350494.6_Nonsense_Mutation_p.R631*|ELP2_ENST00000542824.1_Nonsense_Mutation_p.R566*|ELP2_ENST00000423854.2_Nonsense_Mutation_p.R566*	NM_018255.2	NP_060725.1	Q6IA86	ELP2_HUMAN	elongator acetyltransferase complex subunit 2	636					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				NS(1)|breast(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|urinary_tract(2)	30						TTCCAGAGATCGAACCTGGTC	0.403000													22	40					0	0	1	0	0
FAM149A	25854	broad.mit.edu	37	4	187084747	187084747	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr4:187084747C>T	ENST00000356371.5	+	10	1876	c.1876C>T	c.(1876-1878)Ccc>Tcc	p.P626S	FAM149A_ENST00000514153.1_Missense_Mutation_p.P335S|FAM149A_ENST00000389354.5_Missense_Mutation_p.P335S|FAM149A_ENST00000503432.1_Missense_Mutation_p.P335S|FAM149A_ENST00000502970.1_Missense_Mutation_p.P335S|FAM149A_ENST00000227065.4_Missense_Mutation_p.P335S			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	626										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		ACTAAAAACTCCCAACATCTA	0.458000													9	23					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143091105	143091105	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:143091105C>T	ENST00000367603.2	-	5	5513	c.4771G>A	c.(4771-4773)Gat>Aat	p.D1591N	HIVEP2_ENST00000367604.1_Missense_Mutation_p.D1591N|HIVEP2_ENST00000012134.2_Missense_Mutation_p.D1591N	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AGCTGACCATCTCCTGCTGGT	0.547000													46	104					0	0	1	0	0
MRPS18A	55168	broad.mit.edu	37	6	43655472	43655472	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:43655472G>A	ENST00000372133.3	-	1	56	c.45C>T	c.(43-45)ctC>ctT	p.L15L	MRPS18A_ENST00000372116.1_Silent_p.L15L	NM_018135.3	NP_060605.1	Q9NVS2	RT18A_HUMAN	mitochondrial ribosomal protein S18A	15					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			kidney(3)|large_intestine(1)	4	all_cancers(18;6.56e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000479)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0102)|OV - Ovarian serous cystadenocarcinoma(102;0.137)			GTAGCCCACGGAGAAGCCGCC	0.632000													3	14					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49207033	49207033	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:49207033G>C	ENST00000425340.2	+	2	937	c.820G>C	c.(820-822)Gat>Cat	p.D274H	FUT2_ENST00000391876.4_Missense_Mutation_p.D274H	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	274					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		ACCTGCCAAAGATTTTGCTCT	0.562000													66	161					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742160	10742160	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:10742160G>A	ENST00000586078.1	+	7	560	c.451G>A	c.(451-453)Gag>Aag	p.E151K	SLC44A2_ENST00000335757.5_Missense_Mutation_p.E151K|SLC44A2_ENST00000407327.4_Missense_Mutation_p.E149K	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	151					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GGGAGTGGCTGAGGTGCTTCA	0.587000													27	58					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179304703	179304703	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr1:179304703C>T	ENST00000367619.3	+	4	383	c.240C>T	c.(238-240)ctC>ctT	p.L80L	SOAT1_ENST00000539888.1_Silent_p.L15L|SOAT1_ENST00000535686.1_5'UTR|SOAT1_ENST00000540564.1_Silent_p.L22L	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	80					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	TGACCAATCTCATTGAAAAGT	0.363000													17	20					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47852111	47852111	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr21:47852111G>C	ENST00000359568.5	+	38	8840	c.8733G>C	c.(8731-8733)caG>caC	p.Q2911H	PCNT_ENST00000480896.1_Intron	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2911					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GGAAGTGGCAGAGAGACAAGG	0.617000													9	12					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64892900	64892900	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr5:64892900G>A	ENST00000231524.9	-	8	1658	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	TRIM23_ENST00000274327.7_Silent_p.F429F|TRIM23_ENST00000381018.3_Silent_p.F429F	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	429	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		TGGGCTGCATGAATTCATCCT	0.373000													24	77					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230393	7230393	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:7230393C>T	ENST00000379938.2	+	10	2598	c.2061C>T	c.(2059-2061)atC>atT	p.I687I	RREB1_ENST00000334984.6_Silent_p.I687I|RREB1_ENST00000349384.6_Silent_p.I687I|RREB1_ENST00000379933.3_Silent_p.I687I	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	687					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCGCGCTCATCCGCCACCTGC	0.637000													22	39					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26919162	26919162	+	Missense_Mutation	SNP	G	G	A	rs140105765		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:26919162G>A	ENST00000321765.5	-	3	1432	c.1100C>T	c.(1099-1101)tCg>tTg	p.S367L		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	367					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding	p.S367L(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CCGAAGCATCGAGGGAAGGGA	0.502000													39	125					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17277884	17277884	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:17277884G>A	ENST00000544301.1	+	8	1682	c.1269G>A	c.(1267-1269)ctG>ctA	p.L423L	VIM_ENST00000224237.5_Silent_p.L423L	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	423	Tail.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCCTGAACCTGAGGGGTAAGC	0.363000													17	28					0	0	1	0	0
ID1	3397	broad.mit.edu	37	20	30193467	30193467	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr20:30193467G>A	ENST00000376105.3	+	1	376	c.277G>A	c.(277-279)Gag>Aag	p.E93K	ID1_ENST00000376112.3_Missense_Mutation_p.E93K	NM_181353.2	NP_851998.1	P41134	ID1_HUMAN	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	93	Helix-loop-helix motif.				angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			endometrium(2)|ovary(1)|pancreas(1)	4	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GAGCAAGGTGGAGATTCTCCA	0.607000													10	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179450037	179450037	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:179450037G>C	ENST00000589042.1	-	309	64658	c.64434C>G	c.(64432-64434)atC>atG	p.I21478M	TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I12413M|TTN_ENST00000359218.5_Missense_Mutation_p.I12538M|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I12605M|TTN_ENST00000591111.1_Missense_Mutation_p.I19837M|TTN_ENST00000342992.6_Missense_Mutation_p.I18910M	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19837	Fibronectin type-III 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCAGCTTTGATAGTTATTT	0.408000													66	39					0	0	1	0	0
DTWD1	56986	broad.mit.edu	37	15	49926895	49926895	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr15:49926895G>A	ENST00000251250.6	+	5	778	c.571G>A	c.(571-573)Gac>Aac	p.D191N	DTWD1_ENST00000415425.1_Missense_Mutation_p.D104N|DTWD1_ENST00000558653.1_Missense_Mutation_p.D191N|DTWD1_ENST00000559223.1_3'UTR|DTWD1_ENST00000403028.3_Missense_Mutation_p.D191N	NM_020234.5	NP_064619.2	Q8N5C7	DTWD1_HUMAN	DTW domain containing 1	191								p.D191N(1)		endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		TGATTTGAATGACAGCAAGTG	0.343000													30	162					0	0	1	0	0
LOC101928517	101928517	broad.mit.edu	37	19	51671614	51671614	+	RNA	SNP	C	C	G			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr19:51671614C>G	ENST00000600074.1	-	0	493				SIGLEC17P_ENST00000598286.1_RNA																							CCATCCAGCTCAGTGTCTCCT	0.622000													15	30					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156396116	156396116	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:156396116C>T	ENST00000461166.1	+	2	1218	c.630C>T	c.(628-630)ctC>ctT	p.L210L	TIPARP_ENST00000542783.1_Silent_p.L210L|TIPARP_ENST00000295924.7_Silent_p.L210L|TIPARP_ENST00000486483.1_Silent_p.L210L	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	210							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GTACTGAGCTCTTTCAGGACA	0.423000													27	39					0	0	1	0	0
CITED2	10370	broad.mit.edu	37	6	139694644	139694644	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr6:139694644C>T	ENST00000367651.2	-	2	653	c.438G>A	c.(436-438)atG>atA	p.M146I	CITED2_ENST00000537332.1_Missense_Mutation_p.M146I|CITED2_ENST00000536159.1_Missense_Mutation_p.M146I	NM_006079.4	NP_006070.2	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	146					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)|lung(4)	5	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		TTGTCCCGTTCATCTGGTGGC	0.632000													64	91					0	0	1	0	0
RAD23B	5887	broad.mit.edu	37	9	110091908	110091908	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:110091908C>T	ENST00000358015.3	+	10	1552	c.1201C>T	c.(1201-1203)Ctt>Ttt	p.L401F	RAD23B_ENST00000416373.2_Missense_Mutation_p.L329F	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	401	UBA 2.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						TGCCAATTTTCTTCTACAGCA	0.378000								Direct reversal of damage;Nucleotide excision repair (NER)					26	46					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476606	42476606	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr17:42476606G>A	ENST00000434000.1	-	9	2887	c.2605C>T	c.(2605-2607)Cgg>Tgg	p.R869W	GPATCH8_ENST00000591680.1_Missense_Mutation_p.R947W			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	947	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GTATGACTCCGAGATCGGCTT	0.552000													27	62					0	0	1	0	0
NTHL1	4913	broad.mit.edu	37	16	2090190	2090190	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:2090190C>A	ENST00000219066.1	-	5	777	c.759G>T	c.(757-759)aaG>aaT	p.K253N	NTHL1_ENST00000562951.1_5'UTR	NM_002528.5	NP_002519.1	P78549	NTHL1_HUMAN	nth endonuclease III-like 1 (E. coli)	253					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						TGGTTGCCTTCTTGGTCCACC	0.637000								Base excision repair (BER), DNA glycosylases					73	101					7.63117e-38	7.98338e-38	1	1	0
ALG2	85365	broad.mit.edu	37	9	101980999	101980999	+	Silent	SNP	C	C	T			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:101980999C>T	ENST00000476832.1	-	2	529	c.468G>A	c.(466-468)agG>agA	p.R156R	ALG2_ENST00000319033.6_Silent_p.R63R	NM_033087.3	NP_149078.1	Q9H553	ALG2_HUMAN	ALG2, alpha-1,3/1,6-mannosyltransferase	156					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|prostate(2)	22		Acute lymphoblastic leukemia(62;0.0559)				CAATTGGGGCCCTGTATAGTC	0.453000													12	75					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74345053	74345053	+	Silent	SNP	G	G	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:74345053G>A	ENST00000377044.4	-	9	2429	c.1890C>T	c.(1888-1890)ctC>ctT	p.L630L	TMEM2_ENST00000377066.5_Silent_p.L567L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	630						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CGGTGGGCAGGAGAGTACCCG	0.448000													29	69					0	0	1	0	0
H3F3AP4	440926	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	6	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53778808	53778808	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:53778808delG	ENST00000288139.4	+	24	3138	c.3020delG	c.(3019-3021)aggfs	p.R1007fs	CACNA1D_ENST00000422281.2_Frame_Shift_Del_p.R987fs|CACNA1D_ENST00000350061.5_Frame_Shift_Del_p.R987fs	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AGGGTCTTAAGGGTCCTGCGT	0.532													13	106	---	---	---	---					
XRN1	54464	broad.mit.edu	37	3	142048294	142048294	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr3:142048294delG	ENST00000264951.4	-	37	4500	c.4383delC	c.(4381-4383)tccfs	p.S1461fs	XRN1_ENST00000392981.2_Frame_Shift_Del_p.S1462fs	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1461					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TCCTAAGAAAGGAGAAATCAG	0.373													15	43	---	---	---	---					
TRBV7-6	28592	broad.mit.edu	37	7	142139683	142139684	+	RNA	INS	-	-	A			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr7:142139683_142139684insA	ENST00000390374.3	-	0	94																											cctacacacaGAAAAAAAAATG	0.490													7	89	---	---	---	---					
SFRP1	6422	broad.mit.edu	37	8	41166638	41166640	+	In_Frame_Del	DEL	GCT	GCT	-	rs3055861		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr8:41166638_41166640delGCT	ENST00000220772.3	-	1	376_378	c.39_41delAGC	c.(37-42)gcagcc>gcc	p.13_14AA>A		NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	13					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CACGCCCAGGGCTGCCCCGCGGC	0.764													7	2	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21974697	21974704	+	Frame_Shift_Del	DEL	AACTATTC	AACTATTC	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr9:21974697_21974704delAACTATTC	ENST00000304494.5	-	1	393_400	c.123_130delGAATAGTT	c.(121-132)ccgaatagttacfs	p.NSY42fs	CDKN2A_ENST00000494262.1_Intron|CDKN2A_ENST00000498628.2_Intron|CDKN2A_ENST00000579122.1_Frame_Shift_Del_p.NSY42fs|CDKN2A_ENST00000498124.1_Frame_Shift_Del_p.NSY42fs|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000446177.1_Frame_Shift_Del_p.NSY42fs|CDKN2A_ENST00000579755.1_Intron|CDKN2A_ENST00000361570.3_Intron|CDKN2A_ENST00000530628.2_Intron	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	42					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(23)|p.S43I(6)|p.N42Y(1)|p.S43fs*76(1)|p.0(1)|p.V28_V51del(1)|p.N42T(1)|p.S43R(1)|p.Y44fs*76(1)|p.N42D(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CTCCGACCGTAACTATTCGGTGCGTTGG	0.688		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			55	143	---	---	---	---					
DRGX	644168	broad.mit.edu	37	10	50574313	50574313	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr10:50574313delG	ENST00000374139.2	-	6	650	c.640delC	c.(640-642)cgcfs	p.R214fs	DRGX_ENST00000434016.1_Frame_Shift_Del_p.R219fs			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	219					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						GAGTGCTCGCGGGCCTTCATG	0.672													26	113	---	---	---	---					
PPFIBP2	8495	broad.mit.edu	37	11	7669770	7669771	+	Splice_Site	INS	-	-	AAGGGC			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:7669770_7669771insAAGGGC	ENST00000299492.4	+	18	2185		c.e18+2		PPFIBP2_ENST00000533792.1_Splice_Site|PPFIBP2_ENST00000528883.1_Splice_Site|PPFIBP2_ENST00000530181.1_Splice_Site|PPFIBP2_ENST00000530582.1_Splice_Site	NM_003621.3	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)						cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		ATGGAAAAGGTAAGGGCTCAGC	0.569													20	108	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65270964	65270974	+	RNA	DEL	TGAAGGCTCTA	TGAAGGCTCTA	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr11:65270964_65270974delTGAAGGCTCTA	ENST00000534336.1	+	0	5732_5742					NR_002819.2																						ATTGAATCTCTGAAGGCTCTATGAAAGGAAT	0.327													28	71	---	---	---	---					
NECAP1	25977	broad.mit.edu	37	12	8245310	8245314	+	Frame_Shift_Del	DEL	AAGAA	AAGAA	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:8245310_8245314delAAGAA	ENST00000339754.5	+	5	500_504	c.422_426delAAGAA	c.(421-426)caagaafs	p.QE141fs		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	141					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		AAGGAATCTCAAGAAATGGATGCTC	0.405													7	36	---	---	---	---					
MAGOHB	55110	broad.mit.edu	37	12	10762497	10762517	+	In_Frame_Del	DEL	ATAATTCTCTTCAGTTCTTCC	ATAATTCTCTTCAGTTCTTCC	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr12:10762497_10762517delATAATTCTCTTCAGTTCTTCC	ENST00000320756.2	-	3	267_287	c.177_197delGGAAGAACTGAAGAGAATTAT	c.(175-198)atggaagaactgaagagaattatt>att	p.MEELKRI59del	MAGOHB_ENST00000381881.2_Intron|MAGOHB_ENST00000539554.1_In_Frame_Del_p.MEELKRI13del	NM_018048.3	NP_060518.1	Q96A72	MGN2_HUMAN	mago-nashi homolog B (Drosophila)	59					mRNA processing|mRNA transport|RNA splicing	nucleus	RNA binding			breast(2)|large_intestine(2)	4						ACTGTCATCAATAATTCTCTTCAGTTCTTCCATTACACTCT	0.362													12	33	---	---	---	---					
DOCK9	23348	broad.mit.edu	37	13	99502312	99502312	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr13:99502312delA	ENST00000376460.1	-	36	4082	c.4002delT	c.(4000-4002)tttfs	p.F1334fs	DOCK9_ENST00000448493.2_Frame_Shift_Del_p.F1346fs|DOCK9_ENST00000339416.2_Frame_Shift_Del_p.F1335fs	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1335					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGATATTGTAAAAAAATCCA	0.318													2	4	---	---	---	---					
LCMT1	51451	broad.mit.edu	37	16	25143746	25143746	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:25143746delG	ENST00000399069.3	+	3	384	c.229delG	c.(229-231)gtcfs	p.V77fs	LCMT1_ENST00000380966.4_Frame_Shift_Del_p.V77fs	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	77							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	AGTCCATGGTGTCAGTCAGCT	0.483													18	44	---	---	---	---					
BCAR1	9564	broad.mit.edu	37	16	75269588	75269597	+	Frame_Shift_Del	DEL	GCCACCATCA	GCCACCATCA	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr16:75269588_75269597delGCCACCATCA	ENST00000546196.1	-	5	2765_2774	c.1113_1122delTGATGGTGGC	c.(1111-1122)gctgatggtggcfs	p.ADGG371fs	BCAR1_ENST00000420641.3_Frame_Shift_Del_p.ADGG418fs|BCAR1_ENST00000162330.5_Frame_Shift_Del_p.ADGG400fs|BCAR1_ENST00000393422.2_Frame_Shift_Del_p.ADGG418fs|BCAR1_ENST00000535626.2_Frame_Shift_Del_p.ADGG252fs|BCAR1_ENST00000542031.2_Frame_Shift_Del_p.ADGG398fs|BCAR1_ENST00000538440.2_Frame_Shift_Del_p.ADGG400fs|BCAR1_ENST00000566982.1_5'UTR|BCAR1_ENST00000418647.3_Frame_Shift_Del_p.ADGG446fs|BCAR1_ENST00000393420.6_Frame_Shift_Del_p.ADGG418fs			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	400	Substrate for kinases (By similarity).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGTCGACCACGCCACCATCAGCCACCTCAG	0.690													11	32	---	---	---	---					
LOC101927202	101927202	broad.mit.edu	37	22	39487644	39487644	+	RNA	DEL	C	C	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chr22:39487644delC	ENST00000424436.1	+	0	6																											TATCCCGGAGCCCCAGCCCGG	0.562													2	4	---	---	---	---					
MAGEB4	4115	broad.mit.edu	37	X	30260481	30260491	+	Frame_Shift_Del	DEL	TGCACTGGATC	TGCACTGGATC	-	rs147091800		TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:30260481_30260491delTGCACTGGATC	ENST00000378982.2	+	1	425_435	c.229_239delTGCACTGGATC	c.(229-240)tgcactggatctfs	p.CTGS77fs		NM_002367.3	NP_002358.1	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	77										breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27						AGCTATGTCATGCACTGGATCTGATAAAGGC	0.521													7	8	---	---	---	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-DK-A6B6-01A-11D-A30E-08	TCGA-DK-A6B6-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e119357-c81b-4d46-816a-28e51377424f	5cff717e-c684-42eb-a812-f1471a7e42d1	g.chrX:150817142_150817144delGCT	ENST00000370357.4	+	9	930_932	c.685_687delGCT	c.(685-687)gctdel	p.A236del		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													7	84	---	---	---	---