Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZP2	7783	broad.mit.edu	37	16	21210985	21210985	+	Silent	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr16:21210985G>A	ENST00000574002.1	-	17	2315	c.1833C>T	c.(1831-1833)gtC>gtT	p.V611V	ZP2_ENST00000574091.1_Silent_p.V602V|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000219593.4_Silent_p.V611V			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	611	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		AGTGGAAGTAGACCTGGAGAC	0.507000													4	45					0	0	1	0	0
GCDH	2639	broad.mit.edu	37	19	13002715	13002715	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr19:13002715C>T	ENST00000422947.2	+	4	269	c.11C>T	c.(10-12)tCa>tTa	p.S4L	GCDH_ENST00000457854.1_Silent_p.L66L|GCDH_ENST00000222214.5_Silent_p.L66L|GCDH_ENST00000591470.1_Silent_p.L66L			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	0					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						ATGAGATCCTCATCAGGGACA	0.627000													3	37					0	0	1	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42839672	42839672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr21:42839672G>A	ENST00000398585.3	-	13	1627	c.1567C>T	c.(1567-1569)Cga>Tga	p.R523*	TMPRSS2_ENST00000458356.1_Nonsense_Mutation_p.R486*|TMPRSS2_ENST00000332149.5_Nonsense_Mutation_p.R486*	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	486					proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CTCATTTGTCGATAAATCCAG	0.517000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								4	66					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935719	30935719	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr19:30935719G>A	ENST00000355537.3	+	2	1397	c.1250G>A	c.(1249-1251)gGc>gAc	p.G417D		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.G417D(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCCATGGGCGGCATGTCCCAG	0.632000													4	64					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50358661	50358661	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr7:50358661G>A	ENST00000331340.3	+	2	159	c.4G>A	c.(4-6)Gat>Aat	p.D2N	IKZF1_ENST00000439701.1_Missense_Mutation_p.D2N|IKZF1_ENST00000413698.1_Missense_Mutation_p.D2N|IKZF1_ENST00000343574.5_Missense_Mutation_p.D2N|IKZF1_ENST00000349824.4_Missense_Mutation_p.D2N|IKZF1_ENST00000492782.1_3'UTR|IKZF1_ENST00000346667.4_Missense_Mutation_p.D2N|IKZF1_ENST00000359197.5_Missense_Mutation_p.D2N|IKZF1_ENST00000357364.4_Missense_Mutation_p.D2N|IKZF1_ENST00000440768.2_Missense_Mutation_p.D2N|IKZF1_ENST00000438033.1_Missense_Mutation_p.D2N	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	2					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(41)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAGGACCATGGATGCTGATGA	0.428000			"""D,T"""	BCL6	"""ALL, DLBCL"""								6	145					0	0	1	0	0
ECI2	10455	broad.mit.edu	37	6	4116175	4116175	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr6:4116175C>T	ENST00000465828.1	-	10	1313	c.1028G>A	c.(1027-1029)gGa>gAa	p.G343E	C6orf201_ENST00000380175.4_Intron|C6orf201_ENST00000430835.2_Intron|C6orf201_ENST00000333388.5_Intron|ECI2_ENST00000380125.2_Missense_Mutation_p.G343E|ECI2_ENST00000413766.2_Missense_Mutation_p.G206E|ECI2_ENST00000380118.3_Missense_Mutation_p.G373E|ECI2_ENST00000361538.2_Missense_Mutation_p.G343E			O75521	ECI2_HUMAN	enoyl-CoA delta isomerase 2	373					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	11						TAGCCATCTTCCCTGAAGGAC	0.403000													5	59					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151011992	151011992	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:151011992C>G	ENST00000260843.4	-	3	1506	c.1042G>C	c.(1042-1044)Gaa>Caa	p.E348Q	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_023915.3	NP_076404.3	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	348						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(6)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	19			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATGCGAACTTCCGATCTTCTC	0.338000													13	161					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131371450	131371450	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr9:131371450G>T	ENST00000358161.5	+	36	4758	c.4645G>T	c.(4645-4647)Gaa>Taa	p.E1549*	SPTAN1_ENST00000372731.4_Nonsense_Mutation_p.E1549*|SPTAN1_ENST00000372739.3_Nonsense_Mutation_p.E1549*			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1549					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						AAAGCTAGGAGAATCTCAAAC	0.468000													6	80					0.217242	0.223632	1	1	0
MUC4	4585	broad.mit.edu	37	3	195505814	195505814	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:195505814C>T	ENST00000463781.3	-	2	13096	c.12637G>A	c.(12637-12639)Gac>Aac	p.D4213N	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D4213N|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	970					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.D4213N(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAGTGTCGGTGACAGGA	0.597000													3	2					0	0	1	0	0
ARL6	84100	broad.mit.edu	37	3	97506888	97506888	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:97506888G>C	ENST00000463745.1	+	6	881	c.404G>C	c.(403-405)aGa>aCa	p.R135T	ARL6_ENST00000394206.1_Missense_Mutation_p.R135T|ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000335979.2_Missense_Mutation_p.R135T	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	135					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		ATGGATCTTAGAGATGCAGTG	0.318000													4	57					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89938595	89938595	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr7:89938595G>C	ENST00000389297.4	+	22	2820	c.2569G>C	c.(2569-2571)Gaa>Caa	p.E857Q	C7orf63_ENST00000497910.1_Missense_Mutation_p.E839Q|C7orf63_ENST00000316089.8_Missense_Mutation_p.E811Q	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	857							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						AAGCCTTCAAGAAAAAGCTAT	0.294000													6	78					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85617303	85617303	+	Silent	SNP	T	T	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr4:85617303T>C	ENST00000322366.6	-	57	9077	c.8670A>G	c.(8668-8670)ctA>ctG	p.L2890L	WDFY3_ENST00000295888.4_Silent_p.L2907L			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2907	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCACTCATGTAGATGGGCAC	0.413000													7	137					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505813	195505813	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:195505813T>C	ENST00000463781.3	-	2	13097	c.12638A>G	c.(12637-12639)gAc>gGc	p.D4213G	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D4213G|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	970					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.D4213G(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGAGGAAGTGTCGGTGACAGG	0.592000													3	2					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34851409	34851409	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr7:34851409G>A	ENST00000360581.1	+	4	540	c.412G>A	c.(412-414)Gtc>Atc	p.V138I	NPSR1_ENST00000381539.3_Missense_Mutation_p.V138I|NPSR1_ENST00000359791.1_Missense_Mutation_p.V138I|NPSR1_ENST00000381542.1_Intron|NPSR1_ENST00000531252.1_Missense_Mutation_p.V127I	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	138						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CTCTACCTACGTCCTGGTGTC	0.483000													6	98					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879832	33879832	+	Silent	SNP	G	G	A	rs138645862		TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr20:33879832G>A	ENST00000374408.3	-	1	372	c.276C>T	c.(274-276)agC>agT	p.S92S		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	92										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCTGAGCCTCGCTGAGCTCAG	0.662000													6	43					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39240676	39240676	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr2:39240676C>G	ENST00000426016.1	-	14	2178	c.2092G>C	c.(2092-2094)Gag>Cag	p.E698Q	SOS1_ENST00000402219.2_Missense_Mutation_p.E698Q|SOS1_ENST00000395038.2_Missense_Mutation_p.E698Q			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	698	N-terminal Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				AAGTGGTGCTCTACCCAGTGC	0.333000									Noonan syndrome				6	128					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33628236	33628236	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr13:33628236G>A	ENST00000380099.3	+	2	1160	c.1152G>A	c.(1150-1152)atG>atA	p.M384I	KL_ENST00000426690.2_Missense_Mutation_p.M77I|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	384	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACCCTCACATGAAGTTCCGCC	0.403000													11	236					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	161771157	161771157	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr6:161771157T>G	ENST00000366898.1	-	12	1474	c.1372A>C	c.(1372-1374)Atg>Ctg	p.M458L	PARK2_ENST00000366896.1_Missense_Mutation_p.M309L|PARK2_ENST00000338468.3_Missense_Mutation_p.M267L|PARK2_ENST00000366897.1_Missense_Mutation_p.M430L|PARK2_ENST00000366894.1_Missense_Mutation_p.M267L	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	458					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TGGTCCCCCATGCAGACGCGG	0.622000													3	11					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41752381	41752381	+	Silent	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr22:41752381G>A	ENST00000352645.4	+	21	2675	c.2418G>A	c.(2416-2418)ctG>ctA	p.L806L	ZC3H7B_ENST00000351589.4_Silent_p.L806L	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	822					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACATGTGGCTGAAAAAACACA	0.592000													5	117					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100838498	100838498	+	Silent	SNP	C	C	T			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr6:100838498C>T	ENST00000369208.3	-	12	2822	c.2040G>A	c.(2038-2040)tcG>tcA	p.S680S	SIM1_ENST00000262901.4_Silent_p.S680S			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	680	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GAGATATATCCGAATGCAGAT	0.448000													6	132					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50155783	50155783	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:50155783G>C	ENST00000347869.3	+	25	2517	c.2342G>C	c.(2341-2343)gGa>gCa	p.G781A	RP11-493K19.3_ENST00000425674.1_RNA|RP11-493K19.3_ENST00000437204.1_RNA	NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	781	G-patch.|Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGGCTAAAGGGAGCTGGCCTA	0.572000													3	27					0	0	1	0	0
ANXA13	312	broad.mit.edu	37	8	124693557	124693557	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr8:124693557G>A	ENST00000262219.6	-	12	1064	c.997C>T	c.(997-999)Cag>Tag	p.Q333*	ANXA13_ENST00000419625.1_Nonsense_Mutation_p.Q292*	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13	292					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			AGAGACTTCTGATACTTCTCT	0.468000													8	201					0	0	1	0	0
GATSL3	652968	broad.mit.edu	37	22	30685448	30685448	+	Silent	SNP	C	C	G			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr22:30685448C>G	ENST00000407689.3	-	1	168	c.39G>C	c.(37-39)ctG>ctC	p.L13L	RP1-130H16.18_ENST00000447976.1_Intron|GATSL3_ENST00000404953.3_Silent_p.L13L	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						GGGCGACGCTCAGCACCCGCA	0.736000													2	5					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	58					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012106	151012106	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:151012106C>G	ENST00000260843.4	-	3	1392	c.928G>C	c.(928-930)Gat>Cat	p.D310H	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_023915.3	NP_076404.3	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	310						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(6)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	19			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTATTGGATCCAGGCAAACA	0.343000													13	128					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67250492	67250492	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr17:67250492C>G	ENST00000392676.3	-	32	4272	c.4208G>C	c.(4207-4209)gGa>gCa	p.G1403A	ABCA5_ENST00000588877.1_Missense_Mutation_p.G1403A|ABCA5_ENST00000392677.2_Missense_Mutation_p.G1404A			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1403	ABC transporter 2.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TGCACTCATTCCTTTGACAGC	0.353000													5	117					0	0	1	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368847	162368847	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr1:162368847G>C	ENST00000367929.2	-	3	338	c.229C>G	c.(229-231)Cca>Gca	p.P77A	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	77	SH2.									kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TTTAGGCTTGGAAAGACCTGT	0.408000													5	60					0	0	1	0	0
RP11-242J7.1	0	broad.mit.edu	37	4	185536410	185536413	+	RNA	DEL	TTTG	TTTG	-	rs146473442		TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr4:185536410_185536413delTTTG	ENST00000522554.1	-	0	292																											CAAAGCCGATtttgtttgtttgtt	0.451													2	4	---	---	---	---					
MPP6	51678	broad.mit.edu	37	7	24705666	24705666	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr7:24705666delA	ENST00000222644.5	+	8	1160	c.910delA	c.(910-912)aaafs	p.K308fs	MPP6_ENST00000396475.2_Frame_Shift_Del_p.K308fs|MPP6_ENST00000409761.1_Frame_Shift_Del_p.K196fs			Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)						protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						TATAAGTAGCAAAAAAAAGAA	0.299													7	177	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													7	6	---	---	---	---