Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADPRM	56985	broad.mit.edu	37	17	10608309	10608309	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:10608309C>T	ENST00000379774.4	+	2	157	c.66C>T	c.(64-66)gtC>gtT	p.V22V	ADPRM_ENST00000609540.1_Silent_p.V22V	NM_020233.4	NP_064618.3			ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent																		CCTTTGGCGTCATCGCAGATG	0.423000													8	48					0	0	0.307466	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119120886	119120886	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:119120886G>A	ENST00000264245.4	+	10	1819	c.1287G>A	c.(1285-1287)ccG>ccA	p.P429P		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	429					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GGCCCCCACCGGAACAGCTGA	0.617000													15	46					0	0	0.479597	0	0
CNTLN	54875	broad.mit.edu	37	9	17466040	17466040	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:17466040G>T	ENST00000380647.3	+	22	3677	c.3593G>T	c.(3592-3594)aGa>aTa	p.R1198I	CNTLN_ENST00000425824.1_Missense_Mutation_p.R1198I|CNTLN_ENST00000262360.5_Missense_Mutation_p.R1198I			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	1198						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		CTAAAGCAAAGACTTAACGTT	0.303000													27	27					4.74835e-14	5.68465e-14	0.750413	1	0
MED26	9441	broad.mit.edu	37	19	16686879	16686879	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:16686879C>T	ENST00000263390.3	-	3	2024	c.1762G>A	c.(1762-1764)Gac>Aac	p.D588N	CTD-3222D19.2_ENST00000409035.1_Intron	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	588					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						AAGCGCCCGTCGTCGCCGTGC	0.612000													45	6					0	0	0.870114	0	0
ZNF25	219749	broad.mit.edu	37	10	38241661	38241661	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:38241661C>T	ENST00000302609.7	-	6	977	c.765G>A	c.(763-765)gaG>gaA	p.E255E	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				CATAGGGTTTCTCCCCTGTGT	0.443000													36	96					0	0	0.827153	0	0
MACF1	23499	broad.mit.edu	37	1	39802313	39802313	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:39802313C>A	ENST00000564288.1	+	37	10830	c.10053C>A	c.(10051-10053)ttC>ttA	p.F3351L	MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.F3356L|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.F1791L|MACF1_ENST00000567887.1_Missense_Mutation_p.F3388L|MACF1_ENST00000476350.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3356					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAGCCCTTCAGAGCAACTC	0.418000													12	10					9.31168e-06	1.00613e-05	0.435327	1	0
TERT	7015	broad.mit.edu	37	5	1294371	1294371	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:1294371G>A	ENST00000310581.5	-	2	687	c.630C>T	c.(628-630)gcC>gcT	p.A210A	TERT_ENST00000508104.2_Silent_p.A210A|TERT_ENST00000334602.6_Silent_p.A210A|TERT_ENST00000296820.5_Silent_p.A210A	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	210	RNA-interacting domain 1.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGGGGACCCCGGCCTCCCTGA	0.746000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				4	1					0	0	0.150653	0	0
LRRK1	79705	broad.mit.edu	37	15	101595287	101595287	+	Silent	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:101595287T>A	ENST00000284395.5	+	28	4582	c.4182T>A	c.(4180-4182)ctT>ctA	p.L1394L	LRRK1_ENST00000388948.3_Silent_p.L1397L|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1397	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTGGTCCCTTGACGTCAAGG	0.532000													22	59					0	0	0.717897	0	0
SHC4	399694	broad.mit.edu	37	15	49118194	49118194	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:49118194G>C	ENST00000332408.4	-	12	2295	c.1867C>G	c.(1867-1869)Cca>Gca	p.P623A	SHC4_ENST00000396535.3_Missense_Mutation_p.P380A|SHC4_ENST00000537958.1_Missense_Mutation_p.P337A	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	623					intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		AAAAGTGCTGGATTATTATCT	0.373000													47	127					0	0	0.870114	0	0
DDI2	84301	broad.mit.edu	37	1	15978267	15978267	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:15978267C>G	ENST00000480945.1	+	8	1231	c.1060C>G	c.(1060-1062)Cct>Gct	p.P354A		NM_032341.4	NP_115717.3	Q5TDH0	DDI2_HUMAN	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	354					proteolysis		aspartic-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|stomach(1)	17		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CACCTTTCTTCCTGAGGGAGA	0.502000													9	50					0	0	0.387290	0	0
PLXNB3	5365	broad.mit.edu	37	X	153038980	153038980	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:153038980C>T	ENST00000538966.1	+	20	3431	c.3160C>T	c.(3160-3162)Cga>Tga	p.R1054*	PLXNB3_ENST00000538776.1_Nonsense_Mutation_p.R684*|PLXNB3_ENST00000538282.1_Nonsense_Mutation_p.R641*|PLXNB3_ENST00000361971.5_Nonsense_Mutation_p.R1031*	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1031	IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGGGTGGGCGACTGATCCG	0.687000													36	28					0	0	0.847076	0	0
PIDD	55367	broad.mit.edu	37	11	800221	800221	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:800221C>T	ENST00000347755.5	-	14	2325	c.2184G>A	c.(2182-2184)gtG>gtA	p.V728V	PIDD_ENST00000411829.2_Silent_p.V711V	NM_145886.3|NM_145887.3	NP_665893.2|NP_665894.2	Q9HB75	PIDD_HUMAN	p53-induced death domain protein	728					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding										CCCGCACAGGCACCGCGCCAC	0.687000													8	18					0	0	0.361761	0	0
KLHL1	57626	broad.mit.edu	37	13	70314576	70314576	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:70314576G>A	ENST00000377844.4	-	8	2511	c.1752C>T	c.(1750-1752)gcC>gcT	p.A584A	KLHL1_ENST00000545028.1_Silent_p.A391A	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	584					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGACATACTGGCTACAAATG	0.403000													31	42					0	0	0.827153	0	0
TMEM175	84286	broad.mit.edu	37	4	951684	951684	+	Silent	SNP	G	G	T	rs141810982	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:951684G>T	ENST00000264771.4	+	11	1100	c.915G>T	c.(913-915)gcG>gcT	p.A305A	TMEM175_ENST00000508204.1_Silent_p.A223A|TMEM175_ENST00000515740.1_Silent_p.A189A	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	305						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCCTGAGTGCGACCGGGCCGC	0.622000													46	47					2.43468e-25	3.16757e-25	0.870114	1	0
PJA1	64219	broad.mit.edu	37	X	68382762	68382762	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:68382762G>A	ENST00000361478.1	-	2	697	c.320C>T	c.(319-321)tCg>tTg	p.S107L	PJA1_ENST00000477231.1_5'UTR|PJA1_ENST00000374584.3_Intron|PJA1_ENST00000374571.4_Missense_Mutation_p.S52L|PJA1_ENST00000374583.1_Missense_Mutation_p.S107L	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	107							zinc ion binding	p.S107L(1)		endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						TCTGCTACCCGAAGCTCTGTA	0.522000													20	99					0	0	0.624587	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930751	133930751	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:133930751G>T	ENST00000298622.4	+	2	444	c.306G>T	c.(304-306)ctG>ctT	p.L102L		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGCTGAGCTGCTCAGGGTCA	0.602000													3	47					0.115264	0.116175	0.115264	1	0
MYT1	4661	broad.mit.edu	37	20	62871155	62871155	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62871155A>G	ENST00000536311.1	+	22	3581	c.3217A>G	c.(3217-3219)Aac>Gac	p.N1073D	MYT1_ENST00000328439.1_Missense_Mutation_p.N1046D			Q01538	MYT1_HUMAN	myelin transcription factor 1	1046					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CGAGGAGGAGAACAAGCTCAT	0.572000													88	73					0	0	0.870114	0	0
BIRC8	112401	broad.mit.edu	37	19	53793189	53793189	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:53793189C>G	ENST00000426466.1	-	1	1686	c.439G>C	c.(439-441)Gag>Cag	p.E147Q		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	147					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		ACAAGAACCTCAAGCGTTTTA	0.398000													31	70					0	0	0.796494	0	0
MYO18B	84700	broad.mit.edu	37	22	26219621	26219621	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:26219621C>A	ENST00000335473.7	+	13	2921	c.2671C>A	c.(2671-2673)Ctc>Atc	p.L891I	MYO18B_ENST00000407587.2_Missense_Mutation_p.L891I|MYO18B_ENST00000536101.1_Missense_Mutation_p.L891I	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	891	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCGATGGGGCCTCGAGGATGA	0.597000													103	112					3.45943e-77	4.7684e-77	0.870114	1	0
WDR6	11180	broad.mit.edu	37	3	49051677	49051677	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:49051677C>T	ENST00000395474.3	+	3	2987	c.2707C>T	c.(2707-2709)Ccc>Tcc	p.P903S	WDR6_ENST00000448293.1_Missense_Mutation_p.P822S|WDR6_ENST00000608424.1_Missense_Mutation_p.P873S|WDR6_ENST00000415265.2_Missense_Mutation_p.P321S	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	873					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		ACTTGACCAGCCCGGCCTTGG	0.577000											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	29					0	0	0.740014	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	37					0	0	0.387290	0	0
SAMD10	140700	broad.mit.edu	37	20	62608657	62608657	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62608657C>G	ENST00000369886.3	-	2	368	c.194G>C	c.(193-195)tGg>tCg	p.W65S	SAMD10_ENST00000498830.1_5'UTR|ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron	NM_080621.4	NP_542188.1	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	65										kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)	7	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGAGTCATGCCACGTGAGGCT	0.667000													98	80					0	0	0.870114	0	0
LTF	4057	broad.mit.edu	37	3	46484956	46484956	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:46484956T>C	ENST00000231751.4	-	13	1926	c.1631A>G	c.(1630-1632)tAc>tGc	p.Y544C	LTF_ENST00000417439.1_Missense_Mutation_p.Y542C|LTF_ENST00000426532.2_Missense_Mutation_p.Y500C	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	544	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GTAGCCGTAGTATCTCTCGTT	0.542000													45	150					0	0	0.870114	0	0
BCAR1	9564	broad.mit.edu	37	16	75276878	75276878	+	Silent	SNP	G	G	A	rs5005335		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:75276878G>A	ENST00000546196.1	-	2	1688	c.36C>T	c.(34-36)gaC>gaT	p.D12D	BCAR1_ENST00000418647.3_Silent_p.D87D|BCAR1_ENST00000538440.2_Silent_p.D41D|BCAR1_ENST00000393420.6_Silent_p.D41D|BCAR1_ENST00000162330.5_Silent_p.D41D|BCAR1_ENST00000542031.2_Silent_p.D39D|BCAR1_ENST00000420641.3_Silent_p.D59D|BCAR1_ENST00000393422.2_Silent_p.D59D|BCAR1_ENST00000535626.2_Silent_p.D41D			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	41	SH3.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCCACCAGCCGTCCAGGCCCT	0.622000													4	30					0	0	0.248553	0	0
ZNF831	128611	broad.mit.edu	37	20	57768368	57768368	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:57768368C>T	ENST00000371030.2	+	1	2294	c.2294C>T	c.(2293-2295)cCt>cTt	p.P765L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	765						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCCCCAGCACCTGGCCCCCTC	0.647000													5	9					0	0	0.217242	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764038	77764038	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:77764038G>T	ENST00000521891.2	+	10	5329	c.4881G>T	c.(4879-4881)gaG>gaT	p.E1627D	ZFHX4_ENST00000518282.1_Missense_Mutation_p.E1601D|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E1582D|ZFHX4_ENST00000050961.6_Missense_Mutation_p.E1582D	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1582						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAAGCTGGAGCCCAGTGGTC	0.517000										HNSCC(33;0.089)			15	20					1.67942e-08	1.90334e-08	0.539581	1	0
UBBP4	23666	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000578713.1_Intron|UBBP4_ENST00000583708.1_3'UTR														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													3	61					0	0	0.217242	0	0
GRK5	2869	broad.mit.edu	37	10	121189924	121189924	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:121189924G>A	ENST00000392870.2	+	7	900	c.571G>A	c.(571-573)Gtg>Atg	p.V191M	GRK5_ENST00000369108.3_Missense_Mutation_p.V86M	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	191	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GCAGTATCGAGTGCTAGGAAA	0.458000													46	54					0	0	0.870114	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169954	57169954	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:57169954C>A	ENST00000371244.4	+	7	1165	c.1099C>A	c.(1099-1101)Cca>Aca	p.P367T		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	367					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GAAACCTCATCCAGAAAGGAT	0.468000													36	20					1.96642e-18	2.41075e-18	0.827153	1	0
LMX1A	4009	broad.mit.edu	37	1	165175152	165175152	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:165175152G>A	ENST00000342310.3	-	8	1319	c.937C>T	c.(937-939)Cga>Tga	p.R313*	LMX1A_ENST00000294816.2_Nonsense_Mutation_p.R313*|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000367893.4_Nonsense_Mutation_p.R313*	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	313						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					AGACCCTGTCGGAAGGGATCT	0.582000													18	56					0	0	0.592651	0	0
ZNF536	9745	broad.mit.edu	37	19	31039827	31039827	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:31039827G>A	ENST00000355537.3	+	4	3448	c.3301G>A	c.(3301-3303)Gac>Aac	p.D1101N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CGGCCACGTGGACCCTGCATT	0.542000													21	41					0	0	0.681144	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45924441	45924441	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:45924441T>C	ENST00000395629.2	+	5	1423	c.1093T>C	c.(1093-1095)Tcc>Ccc	p.S365P	MAPK8IP1_ENST00000241014.2_Missense_Mutation_p.S375P			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	375					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		CAGCGCCCTGTCCTATGACTC	0.672000													5	3					0	0	0.248553	0	0
LILRB1	10859	broad.mit.edu	37	19	55148021	55148021	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:55148021C>T	ENST00000396331.1	+	15	2081	c.1724C>T	c.(1723-1725)gCc>gTc	p.A575V	LILRB1_ENST00000396315.1_Missense_Mutation_p.A577V|LILRB1_ENST00000396321.2_Missense_Mutation_p.A575V|LILRB1_ENST00000396317.1_Missense_Mutation_p.A559V|LILRB1_ENST00000448689.1_3'UTR|LILRB1_ENST00000396332.4_Missense_Mutation_p.A576V|LILRB1_ENST00000427581.2_Missense_Mutation_p.A626V|AC009892.10_ENST00000456337.1_Intron|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000324602.7_Missense_Mutation_p.A577V|LILRB1_ENST00000434867.2_Missense_Mutation_p.A575V|LILRB1_ENST00000396327.3_Missense_Mutation_p.A576V|LILRB1_ENST00000418536.2_Missense_Mutation_p.A559V	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	575					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		AGAGAAATGGCCTCTCCTCCT	0.582000										HNSCC(37;0.09)			28	31					0	0	0.750413	0	0
FMO2	2327	broad.mit.edu	37	1	171162520	171162520	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:171162520C>T	ENST00000441535.1	+	3	296	c.179C>T	c.(178-180)aCc>aTc	p.T60I	FMO2_ENST00000209929.7_Missense_Mutation_p.T60I|FMO2_ENST00000529935.1_3'UTR	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	60					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCTGTCGTTACCAACACCAGC	0.348000													75	62					0	0	0.870114	0	0
PSMD10	5716	broad.mit.edu	37	X	107331994	107331994	+	Silent	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:107331994A>G	ENST00000217958.3	-	2	298	c.201T>C	c.(199-201)aaT>aaC	p.N67N	PSMD10_ENST00000372296.1_Silent_p.N67N|PSMD10_ENST00000372295.1_Silent_p.N67N|PSMD10_ENST00000361815.5_Silent_p.N67N|PSMD10_ENST00000340200.5_Intron	NM_002814.3|NM_170750.2	NP_002805.1|NP_736606.1	O75832	PSD10_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	67	Interaction with RB1.|Interaction with RELA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						CGTCTTTATCATTCACTGGCA	0.413000													212	193					0	0	0.870114	0	0
CNN1	1264	broad.mit.edu	37	19	11660487	11660487	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:11660487C>A	ENST00000592923.1	+	8	1198	c.621C>A	c.(619-621)ggC>ggA	p.G207G	CNN1_ENST00000544952.1_Silent_p.G237G|CNN1_ENST00000535659.2_Silent_p.G207G|CNN1_ENST00000252456.2_Silent_p.G257G			P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	257					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						CGCAGCGGGGCATGACGGTGT	0.652000													28	9					7.76418e-22	9.94908e-22	0.693898	1	0
BAGE2	85319	broad.mit.edu	37	21	11097575	11097575	+	RNA	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr21:11097575C>A	ENST00000470054.1	-	0	294									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gctccaacctccagctcacca	0.542000													11	79					9.31168e-06	1.00613e-05	0.435327	1	0
CDH13	1012	broad.mit.edu	37	16	82891976	82891976	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:82891976C>T	ENST00000566620.1	+	2	345	c.55C>T	c.(55-57)Cta>Tta	p.L19L	CDH13_ENST00000567445.1_Silent_p.L19L|CDH13_ENST00000428848.3_Silent_p.L19L|CDH13_ENST00000431540.3_Silent_p.L19L|CDH13_ENST00000268613.10_Silent_p.L66L|CDH13_ENST00000446376.2_Silent_p.L19L|CDH13_ENST00000565636.1_Silent_p.L19L	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	19					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GGTGCTGCTGCTAACATCTGC	0.418000													35	28					0	0	0.804634	0	0
NDC80	10403	broad.mit.edu	37	18	2575029	2575029	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:2575029C>T	ENST00000261597.4	+	3	325	c.143C>T	c.(142-144)cCg>cTg	p.P48L		NM_006101.2	NP_006092.1	O14777	NDC80_HUMAN	NDC80 kinetochore complex component	48	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			NS(1)|biliary_tract(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)|urinary_tract(2)	22						ATAAACAAACCGACATCTGAA	0.303000													10	12					0	0	0.500413	0	0
TTN	7273	broad.mit.edu	37	2	179649056	179649056	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:179649056A>G	ENST00000589042.1	-	16	2740	c.2516T>C	c.(2515-2517)aTt>aCt	p.I839T	TTN_ENST00000359218.5_Missense_Mutation_p.I793T|TTN_ENST00000460472.2_Missense_Mutation_p.I793T|TTN_ENST00000342992.6_Missense_Mutation_p.I839T|TTN_ENST00000342175.6_Missense_Mutation_p.I793T|TTN_ENST00000591111.1_Missense_Mutation_p.I839T|TTN_ENST00000360870.5_Missense_Mutation_p.I839T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	839							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATGTGGCAATAGCACTACC	0.468000													27	30					0	0	0.779181	0	0
ZNF205	7755	broad.mit.edu	37	16	3168975	3168975	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:3168975G>T	ENST00000382192.3	+	6	759	c.554G>T	c.(553-555)cGg>cTg	p.R185L	RP11-473M20.14_ENST00000576490.1_RNA|ZNF205_ENST00000219091.4_Missense_Mutation_p.R185L|RP11-473M20.14_ENST00000575139.1_RNA	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	185	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						GGCTCCAGCCGGCAGGCAGGA	0.667000													31	62					3.09479e-21	3.92622e-21	0.827153	1	0
GUCY1A3	2982	broad.mit.edu	37	4	156631721	156631721	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:156631721C>T	ENST00000296518.7	+	6	613	c.404C>T	c.(403-405)tCt>tTt	p.S135F	GUCY1A3_ENST00000393832.3_5'UTR|GUCY1A3_ENST00000515602.1_3'UTR|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.S135F|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.S135F|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.S135F|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.S135F|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.S135F			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	135				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATCAAAGAATCTCTTGGTGAA	0.383000													30	25					0	0	0.812448	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595303	140595303	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:140595303C>G	ENST00000341948.4	+	1	1795	c.1608C>G	c.(1606-1608)caC>caG	p.H536Q		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		536	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTCAGACCACGGCTCCCCGG	0.677000													3	36					0	0	0.115264	0	0
KDM5B	10765	broad.mit.edu	37	1	202709880	202709880	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:202709880T>C	ENST00000367265.3	-	20	4170	c.3006A>G	c.(3004-3006)gcA>gcG	p.A1002A	KDM5B_ENST00000367264.2_Silent_p.A1038A	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1002					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TGGGCAGATATGCAGGGATCT	0.443000													11	47					0	0	0.435327	0	0
UBXN11	91544	broad.mit.edu	37	1	26610895	26610895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:26610895G>A	ENST00000314675.7	-	7	650	c.571C>T	c.(571-573)Cag>Tag	p.Q191*	UBXN11_ENST00000374223.1_Nonsense_Mutation_p.Q68*|UBXN11_ENST00000374222.1_Nonsense_Mutation_p.Q311*|UBXN11_ENST00000374217.2_Nonsense_Mutation_p.Q278*|UBXN11_ENST00000357089.4_Nonsense_Mutation_p.Q278*|UBXN11_ENST00000374221.3_Nonsense_Mutation_p.Q311*	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	311						cytoplasm|cytoskeleton				endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						TGCATCAGCTGCCTGCCCACC	0.627000													14	33					0	0	0.520397	0	0
COL4A5	1287	broad.mit.edu	37	X	107938638	107938638	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:107938638C>A	ENST00000328300.6	+	52	5207	c.4963C>A	c.(4963-4965)Ctg>Atg	p.L1655M	COL4A5_ENST00000361603.2_Missense_Mutation_p.L1649M	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1649	Collagen IV NC1.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CAGCTTTTGGCTGGCAACTGT	0.463000									Alport syndrome with Diffuse Leiomyomatosis				54	68					4.02486e-48	5.40179e-48	0.870114	1	0
FMO3	2328	broad.mit.edu	37	1	171073019	171073019	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:171073019G>A	ENST00000367755.4	+	3	337	c.226G>A	c.(226-228)Gat>Aat	p.D76N	FMO3_ENST00000392085.2_Missense_Mutation_p.D76N|FMO3_ENST00000538429.1_Intron|FMO3_ENST00000542847.1_Missense_Mutation_p.D56N	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	76					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCCATTTCCCGATGACTTCCC	0.423000													31	20					0	0	0.760397	0	0
C10orf88	80007	broad.mit.edu	37	10	124692098	124692098	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:124692098C>A	ENST00000481909.1	-	6	1407	c.1183G>T	c.(1183-1185)Gat>Tat	p.D395Y	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	395										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TCAATGTAATCCATAAGTTTC	0.353000													6	24					2.0095e-06	2.21828e-06	0.248553	1	0
C2CD3	26005	broad.mit.edu	37	11	73817441	73817441	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:73817441C>A	ENST00000334126.7	-	13	2286	c.2060G>T	c.(2059-2061)gGt>gTt	p.G687V	C2CD3_ENST00000313663.7_Missense_Mutation_p.G687V			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	687						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TGGAGACTGACCATTTTCTTG	0.438000													30	87					2.32173e-10	2.66686e-10	0.804634	1	0
TPO	7173	broad.mit.edu	37	2	1488451	1488451	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:1488451C>A	ENST00000345913.4	+	9	1513	c.1422C>A	c.(1420-1422)gaC>gaA	p.D474E	TPO_ENST00000337415.3_Missense_Mutation_p.D474E|TPO_ENST00000382201.3_Missense_Mutation_p.D474E|TPO_ENST00000349624.3_Missense_Mutation_p.D301E|TPO_ENST00000329066.4_Missense_Mutation_p.D474E|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000346956.3_Missense_Mutation_p.D474E|TPO_ENST00000382198.1_Missense_Mutation_p.D301E	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	474					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AAGGCTATGACTCCACCGCCA	0.602000													28	32					7.26314e-15	8.77773e-15	0.717897	1	0
TBCCD1	55171	broad.mit.edu	37	3	186276258	186276258	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:186276258C>T	ENST00000424280.1	-	3	919	c.440G>A	c.(439-441)aGa>aAa	p.R147K	TBCCD1_ENST00000446782.1_Missense_Mutation_p.R51K|TBCCD1_ENST00000338733.5_Missense_Mutation_p.R147K	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	147					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding	p.R147I(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		AGATTTGTTTCTGGGACTGGG	0.408000													19	81					0	0	0.624587	0	0
STAB1	23166	broad.mit.edu	37	3	52538860	52538860	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:52538860C>A	ENST00000321725.6	+	12	1421	c.1345C>A	c.(1345-1347)Cag>Aag	p.Q449K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	449	FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCTGGCCGGGCAGGAGATCAC	0.607000													11	32					0.000673444	0.000706701	0.361761	1	0
MLLT1	4298	broad.mit.edu	37	19	6230639	6230639	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:6230639T>C	ENST00000252674.7	-	4	525	c.362A>G	c.(361-363)aAg>aGg	p.K121R		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	121					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						GAAGGTGAGCTTCTCGCAGCG	0.647000			T	MLL	AL								83	31					0	0	0.870114	0	0
SFTPB	6439	broad.mit.edu	37	2	85894867	85894867	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:85894867C>A	ENST00000342375.3	-	3	265	c.130G>T	c.(130-132)Gag>Tag	p.E44*	SFTPB_ENST00000393822.3_Nonsense_Mutation_p.E56*|SFTPB_ENST00000519937.2_Nonsense_Mutation_p.E44*|SFTPB_ENST00000409383.1_Nonsense_Mutation_p.E56*	NM_000542.3|NM_198843.2	NP_000533.3|NP_942140.2	P07988	PSPB_HUMAN	surfactant protein B	44	Saposin A-type.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)	16						AATGCTTGCTCCAGGCTTTGG	0.592000													50	35					4.88482e-21	6.16649e-21	0.870114	1	0
ITGAM	3684	broad.mit.edu	37	16	31335844	31335844	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:31335844G>T	ENST00000544665.3	+	17	2201	c.2130G>T	c.(2128-2130)caG>caT	p.Q710H	ITGAM_ENST00000287497.8_Missense_Mutation_p.Q709H	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	709					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GGCTGACCCAGACTTGTGAGA	0.602000													8	9					0.0692343	0.070619	0.361761	1	0
RBM14	10432	broad.mit.edu	37	11	66384255	66384255	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:66384255T>A	ENST00000310137.4	+	1	203	c.64T>A	c.(64-66)Ttt>Att	p.F22I	RBM14_ENST00000393979.3_Missense_Mutation_p.F22I|RBM14_ENST00000409738.4_Missense_Mutation_p.F22I|RBM14_ENST00000409372.1_Missense_Mutation_p.F22I|RBM14-RBM4_ENST00000412278.2_Missense_Mutation_p.F22I|RBM14-RBM4_ENST00000500635.2_Missense_Mutation_p.F22I|RBM4_ENST00000514361.3_Missense_Mutation_p.F22I|RBM14_ENST00000443702.1_Missense_Mutation_p.F22I|RBM14-RBM4_ENST00000511114.1_3'UTR|RBM4_ENST00000503028.2_De_novo_Start_InFrame	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	22	RRM 1.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GGCAGCCCTCTTTGCGCCCTA	0.647000													4	17					0	0	0.184627	0	0
GRIK3	2899	broad.mit.edu	37	1	37270762	37270762	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:37270762C>T	ENST00000373091.3	-	15	2407	c.2391G>A	c.(2389-2391)gaG>gaA	p.E797E	GRIK3_ENST00000373093.4_Silent_p.E797E	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	797					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GCCACCACTTCTCCTTCATGA	0.602000													20	62					0	0	0.624587	0	0
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:137328351C>T	ENST00000540193.1	+	9	1912	c.989C>T	c.(988-990)tCc>tTc	p.S330F	RXRA_ENST00000481739.1_Missense_Mutation_p.S427F|RXRA_ENST00000356384.4_3'UTR			P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607000													17	55					0	0	0.539581	0	0
MYO3A	53904	broad.mit.edu	37	10	26463335	26463335	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:26463335C>T	ENST00000265944.5	+	30	4308	c.4142C>T	c.(4141-4143)aCa>aTa	p.T1381I	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1381					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGGATTGTCACAACACCAACA	0.398000													44	66					0	0	0.870114	0	0
STX5	6811	broad.mit.edu	37	11	62592798	62592798	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:62592798G>C	ENST00000294179.3	-	7	707	c.554C>G	c.(553-555)tCt>tGt	p.S185C	STX5_ENST00000377897.4_Missense_Mutation_p.S185C|STX5_ENST00000394690.1_Missense_Mutation_p.S131C|STX5_ENST00000541317.1_Missense_Mutation_p.S89C	NM_001244666.1|NM_003164.4	NP_001231595.1|NP_003155.2	Q13190	STX5_HUMAN	syntaxin 5	185					intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	18						ATTGGACATAGAAGCCAGTTT	0.493000													234	155					0	0	0.870114	0	0
DHX34	9704	broad.mit.edu	37	19	47876898	47876898	+	Missense_Mutation	SNP	C	C	T	rs141177029	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:47876898C>T	ENST00000328771.4	+	9	2354	c.2005C>T	c.(2005-2007)Cgc>Tgc	p.R669C		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	669						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GTGGTGCCGCCGCCGGGGCAT	0.657000													17	30					0	0	0.667858	0	0
ZNF324B	388569	broad.mit.edu	37	19	58965138	58965138	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:58965138G>A	ENST00000336614.4	+	2	177	c.70G>A	c.(70-72)Gcc>Acc	p.A24T	ZNF324B_ENST00000391696.1_5'UTR|ZNF324B_ENST00000594214.1_Missense_Mutation_p.A24T|ZNF324B_ENST00000545523.1_Missense_Mutation_p.A24T	NM_207395.2	NP_997278.2	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCGCAGAGGGCCCTGTACCG	0.567000													39	58					0	0	0.870114	0	0
H6PD	9563	broad.mit.edu	37	1	9324741	9324741	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:9324741G>T	ENST00000377403.2	+	5	2491	c.2189G>T	c.(2188-2190)aGc>aTc	p.S730I	H6PD_ENST00000602477.1_Missense_Mutation_p.S741I	NM_001282587.1|NM_004285.3	NP_001269516.1|NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	730	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CGCCGCATGAGCCTTAGCCTG	0.652000													8	27					3.27435e-08	3.67824e-08	0.457914	1	0
PDZD2	23037	broad.mit.edu	37	5	32059421	32059421	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:32059421C>G	ENST00000438447.1	+	13	2665	c.2277C>G	c.(2275-2277)agC>agG	p.S759R	PDZD2_ENST00000282493.3_Missense_Mutation_p.S759R			O15018	PDZD2_HUMAN	PDZ domain containing 2	759	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						ACATTCACAGCCTTGCTCCAG	0.468000													16	15					0	0	0.557998	0	0
TRAV3	28690	broad.mit.edu	37	14	22192095	22192095	+	RNA	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:22192095G>A	ENST00000390425.2	+	0	136																											GGGCTGGAAAGGACCCCCCCA	0.582000													47	49					0	0	0.870114	0	0
HDAC6	10013	broad.mit.edu	37	X	48682372	48682372	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:48682372A>G	ENST00000334136.5	+	27	3522	c.3344A>G	c.(3343-3345)cAt>cGt	p.H1115R	HDAC6_ENST00000444343.2_Missense_Mutation_p.H1129R|HDAC6_ENST00000376619.2_Missense_Mutation_p.H1115R			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1115					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	TGGTGTCCCCATTTGGTGGCA	0.517000													34	86					0	0	0.834066	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520917	33520917	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:33520917G>T	ENST00000297307.5	-	1	495	c.410C>A	c.(409-411)tCt>tAt	p.S137Y		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	137	DUF6 1.					integral to membrane											GACGGTGGAAGAACCTTTGCG	0.587000													32	136					1.48734e-19	1.84112e-19	0.864702	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	36					0	0	0.387290	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40629667	40629667	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:40629667A>G	ENST00000264649.6	+	6	565	c.434A>G	c.(433-435)cAt>cGt	p.H145R	ATP6V0A1_ENST00000343619.4_Intron|ATP6V0A1_ENST00000537728.1_Intron|ATP6V0A1_ENST00000544137.1_Intron|ATP6V0A1_ENST00000393829.2_Intron|ATP6V0A1_ENST00000546249.1_Intron|ATP6V0A1_ENST00000585525.1_Intron	NM_001130020.1|NM_005177.3	NP_001123492.1|NP_005168.2	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	141					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		GCTGAATTGCATCATCAGCAG	0.443000													39	36					0	0	0.870114	0	0
ZNF761	388561	broad.mit.edu	37	19	53958820	53958820	+	RNA	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:53958820T>C	ENST00000454407.1	+	0	1512							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GAGAGAAACCTTACAAGTGTA	0.408000													4	277					0	0	0.248553	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20610169	20610169	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:20610169C>A	ENST00000202677.7	-	10	1078	c.1071G>T	c.(1069-1071)caG>caT	p.Q357H		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)						activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						GGCTTTTGTCCTGCTCCGTGG	0.537000													104	111					2.27795e-59	3.10629e-59	0.870114	1	0
OGT	8473	broad.mit.edu	37	X	70775117	70775117	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:70775117A>G	ENST00000373719.3	+	7	1023	c.806A>G	c.(805-807)tAc>tGc	p.Y269C	OGT_ENST00000373701.3_Missense_Mutation_p.Y259C	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	269					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GCTTGTGTATACTATGAGCAA	0.483000													64	72					0	0	0.870114	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348423	30348423	+	Silent	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:30348423G>C	ENST00000327564.7	+	1	400	c.339G>C	c.(337-339)ctG>ctC	p.L113L	LRRC37B_ENST00000341671.7_Silent_p.L86L|LRRC37B_ENST00000584368.1_Silent_p.L98L|LRRC37B_ENST00000394713.3_Silent_p.L86L|LRRC37B_ENST00000543378.2_Silent_p.L4L			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	86						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TGTCAGCCCTGCCTCAGGAAC	0.592000													16	57					0	0	0.500413	0	0
GABBR1	2550	broad.mit.edu	37	6	29598366	29598366	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:29598366G>A	ENST00000377034.4	-	4	679	c.344C>T	c.(343-345)aCg>aTg	p.T115M	GABBR1_ENST00000377016.4_Intron|GABBR1_ENST00000376977.3_Missense_Mutation_p.T115M	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	115	Sushi 2.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.T115M(1)		endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GTCCCCACCCGTCAGGAAAAC	0.562000													14	33					0	0	0.520397	0	0
NRXN2	9379	broad.mit.edu	37	11	64374714	64374714	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64374714G>A	ENST00000265459.6	-	23	5554	c.5093C>T	c.(5092-5094)aCg>aTg	p.T1698M	NRXN2_ENST00000377551.1_Missense_Mutation_p.T1698M|NRXN2_ENST00000377559.3_Missense_Mutation_p.T1628M|NRXN2_ENST00000301894.2_Missense_Mutation_p.T652M|NRXN2_ENST00000409571.1_Missense_Mutation_p.T1691M	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1698					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CTTGCTGGGCGTCTTGGGGGC	0.637000													9	31					0	0	0.361761	0	0
SYT16	83851	broad.mit.edu	37	14	62547819	62547819	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:62547819G>C	ENST00000430451.2	+	4	1458	c.1261G>C	c.(1261-1263)Gcc>Ccc	p.A421P	RP11-355I22.5_ENST00000553990.1_lincRNA	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	421	C2 1.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGTCACCTTTGCCAAGCTGGA	0.567000													12	10					0	0	0.500413	0	0
NIM1K	167359	broad.mit.edu	37	5	43245942	43245942	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:43245942G>A	ENST00000512796.1	+	2	1564	c.65G>A	c.(64-66)cGc>cAc	p.R22H	NIM1_ENST00000326035.2_Missense_Mutation_p.R22H			Q8IY84	NIM1_HUMAN		22							ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.R22H(1)									TGGGATCGGCGCGACAGTGTA	0.597000													75	57					0	0	0.870114	0	0
CCDC28A	25901	broad.mit.edu	37	6	139097341	139097341	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:139097341C>A	ENST00000332797.6	+	2	509	c.354C>A	c.(352-354)gcC>gcA	p.A118A		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	118										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		AAAAAAATGCCATTCCAGTGA	0.388000													40	10					2.77807e-22	3.59598e-22	0.864702	1	0
CAPN5	726	broad.mit.edu	37	11	76796098	76796098	+	Splice_Site	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:76796098G>T	ENST00000278559.3	+	2	354		c.e2+1		CAPN5_ENST00000531028.1_Intron|CAPN5_ENST00000529629.1_Splice_Site|CAPN5_ENST00000456580.2_Splice_Site	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5						proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity	p.?(1)		NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						GCGACCCAAGGTCAGTGTCTG	0.677000													6	28					8.12818e-05	8.6362e-05	0.248553	1	0
CEP290	80184	broad.mit.edu	37	12	88486515	88486515	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:88486515C>A	ENST00000552810.1	-	29	3747	c.3404G>T	c.(3403-3405)aGg>aTg	p.R1135M	CEP290_ENST00000309041.7_Missense_Mutation_p.R1137M|CEP290_ENST00000397838.3_Missense_Mutation_p.R195M|CEP290_ENST00000547691.2_Missense_Mutation_p.R195M	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1135					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						AATCCGTTGCCTATCAGCATC	0.368000													28	59					1.16021e-09	1.32077e-09	0.717897	1	0
ZNF780A	284323	broad.mit.edu	37	19	40580973	40580973	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:40580973T>C	ENST00000450241.2	-	6	1585	c.1274A>G	c.(1273-1275)cAa>cGa	p.Q425R	ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000595687.2_Missense_Mutation_p.Q459R|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000455521.1_Missense_Mutation_p.Q460R|ZNF780A_ENST00000594395.1_Missense_Mutation_p.Q460R|ZNF780A_ENST00000340963.5_Missense_Mutation_p.Q459R			O75290	Z780A_HUMAN	zinc finger protein 780A	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTCAATAAGTTGGCAATGATA	0.403000													68	104					0	0	0.870114	0	0
SRGAP2	23380	broad.mit.edu	37	1	206626557	206626557	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:206626557A>G	ENST00000414007.1	+	16	1771	c.1771A>G	c.(1771-1773)Atc>Gtc	p.I591V	SRGAP2_ENST00000471256.1_3'UTR|SRGAP2_ENST00000419187.2_Missense_Mutation_p.I36V			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	731	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					ATGTGAGCCCATCGAGGCCAT	0.522000													2	2					0	0	0.115264	0	0
SLC29A1	2030	broad.mit.edu	37	6	44197137	44197137	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:44197137G>C	ENST00000393841.1	+	4	531	c.40G>C	c.(40-42)Gtc>Ctc	p.V14L	SLC29A1_ENST00000371713.1_Missense_Mutation_p.V14L|SLC29A1_ENST00000313248.7_Missense_Mutation_p.V93L|SLC29A1_ENST00000371755.3_Missense_Mutation_p.V14L|SLC29A1_ENST00000371740.5_Missense_Mutation_p.V14L|SLC29A1_ENST00000371731.1_Missense_Mutation_p.V14L|SLC29A1_ENST00000393844.1_Missense_Mutation_p.V14L|SLC29A1_ENST00000371708.1_Missense_Mutation_p.V14L|SLC29A1_ENST00000427851.2_Missense_Mutation_p.V14L|SLC29A1_ENST00000371724.1_Missense_Mutation_p.V14L	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	14					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	ATACAAAGCTGTCTGGCTTAT	0.562000													34	17					0	0	0.847076	0	0
IFT172	26160	broad.mit.edu	37	2	27672643	27672643	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:27672643C>A	ENST00000260570.3	-	37	4178	c.4075G>T	c.(4075-4077)Gac>Tac	p.D1359Y		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1359					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TTGACAAGGTCCAGATTCAGA	0.522000													47	44					5.57489e-27	7.32782e-27	0.870114	1	0
MDM4	4194	broad.mit.edu	37	1	204511994	204511994	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:204511994G>A	ENST00000367182.3	+	8	756	c.594G>A	c.(592-594)ctG>ctA	p.L198L	MDM4_ENST00000454264.2_Silent_p.L198L|MDM4_ENST00000391947.2_3'UTR|MDM4_ENST00000463049.1_3'UTR|MDM4_ENST00000507825.2_Intron|MDM4_ENST00000367183.3_Intron	NM_001204171.1|NM_001278516.1|NM_001278517.1|NM_001278518.1|NM_001278519.1|NM_002393.4	NP_001191100.1|NP_001265445.1|NP_001265446.1|NP_001265447.1|NP_001265448.1|NP_002384.2	O15151	MDM4_HUMAN	Mdm4 p53 binding protein homolog (mouse)	198					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TAGCTGGCCTGCCTTGGTGGT	0.388000			A		"""GBM, bladder, retinoblastoma"""								19	39					0	0	0.639603	0	0
TSPAN10	83882	broad.mit.edu	37	17	79612041	79612041	+	RNA	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:79612041C>T	ENST00000328585.4	+	0	150				TSPAN10_ENST00000572675.1_RNA	NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGAAGCCCCTCTCTGTGCACA	0.647000													10	28					0	0	0.411799	0	0
ATMIN	23300	broad.mit.edu	37	16	81076953	81076953	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:81076953C>G	ENST00000566488.1	+	3	1345	c.382C>G	c.(382-384)Ctt>Gtt	p.L128V	ATMIN_ENST00000564241.1_Missense_Mutation_p.L128V|ATMIN_ENST00000299575.4_Missense_Mutation_p.L284V|ATMIN_ENST00000539819.1_3'UTR			O43313	ATMIN_HUMAN	ATM interactor	284					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						CAAGCAGACTCTTACAACACC	0.433000													33	59					0	0	0.779181	0	0
USP24	23358	broad.mit.edu	37	1	55562240	55562240	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:55562240C>A	ENST00000294383.6	-	50	5991	c.5992G>T	c.(5992-5994)Gac>Tac	p.D1998Y	USP24_ENST00000407756.1_Missense_Mutation_p.D1838Y	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1998					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						TCATTTAGGTCAAATTCTTCT	0.323000													28	11					1.36615e-20	1.70768e-20	0.769981	1	0
PCDH1	5097	broad.mit.edu	37	5	141233975	141233975	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:141233975T>C	ENST00000287008.3	-	5	3493	c.3346A>G	c.(3346-3348)Atg>Gtg	p.M1116V	PCDH1_ENST00000503492.1_3'UTR	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	0					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTGCCTGTCATGGCGACATCA	0.592000													10	39					0	0	0.457914	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77323595	77323595	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:77323595C>T	ENST00000558012.1	+	10	1206	c.717C>T	c.(715-717)tcC>tcT	p.S239S	PSTPIP1_ENST00000557995.1_3'UTR|PSTPIP1_ENST00000559295.1_Silent_p.S239S|PSTPIP1_ENST00000267939.5_Silent_p.S238S|PSTPIP1_ENST00000379595.3_Silent_p.S239S	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	239					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						ACCAGCTCTCCATGCAGTGTG	0.617000													65	100					0	0	0.870114	0	0
FAM58A	92002	broad.mit.edu	37	X	152858159	152858159	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:152858159G>T	ENST00000406277.2	-	6	558	c.456C>A	c.(454-456)aaC>aaA	p.N152K	FAM58A_ENST00000370175.4_5'UTR	NM_001130997.1|NM_152274.3	NP_001124469.1|NP_689487.2	Q8N1B3	FA58A_HUMAN	family with sequence similarity 58, member A	154					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTTCAGCCAGTTCTGGAGGG	0.612000													7	21					0.0581538	0.0595551	0.335167	1	0
EXTL1	2134	broad.mit.edu	37	1	26349272	26349272	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:26349272C>T	ENST00000374280.3	+	1	1002	c.135C>T	c.(133-135)ggC>ggT	p.G45G		NM_004455.2	NP_004446.2	Q92935	EXTL1_HUMAN	exostosin-like glycosyltransferase 1	45					skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|stomach(1)|urinary_tract(1)	23		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCCCAAGGCTGGCCCCGCT	0.652000													7	9					0	0	0.307466	0	0
GPSM2	29899	broad.mit.edu	37	1	109439511	109439511	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:109439511G>T	ENST00000406462.2	+	4	855	c.82G>T	c.(82-84)Gcc>Tcc	p.A28S	GPSM2_ENST00000264126.3_Missense_Mutation_p.A28S|AKNAD1_ENST00000357393.4_Intron			P81274	GPSM2_HUMAN	G-protein signaling modulator 2						G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)	14		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		CCTAGAGCTGGCCTTGGAAGG	0.418000													40	135					2.79147e-13	3.31081e-13	0.870114	1	0
FSHR	2492	broad.mit.edu	37	2	49189908	49189908	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:49189908G>A	ENST00000406846.2	-	10	2171	c.2052C>T	c.(2050-2052)taC>taT	p.Y684Y	FSHR_ENST00000304421.4_Silent_p.Y658Y|FSHR_ENST00000541117.1_Silent_p.Y420Y|FSHR_ENST00000346173.3_Silent_p.Y622Y	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	684					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GGACAAGTATGTAAGTGGAAC	0.418000									Gonadal Dysgenesis, 46 XX				20	54					0	0	0.667858	0	0
FRMD7	90167	broad.mit.edu	37	X	131233527	131233527	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:131233527C>T	ENST00000298542.4	-	3	349	c.174G>A	c.(172-174)gaG>gaA	p.E58E	FRMD7_ENST00000464296.1_Silent_p.E58E	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	58	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					GCTTCAAAAGCTCCAGCCAAA	0.343000													50	117					0	0	0.870114	0	0
CCR1	1230	broad.mit.edu	37	3	46245233	46245233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:46245233C>T	ENST00000296140.3	-	2	697	c.572G>A	c.(571-573)aGc>aAc	p.S191N	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	191					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CTCTCGTAGGCTTTCGTGAGG	0.493000													21	37					0	0	0.624587	0	0
FAM179B	23116	broad.mit.edu	37	14	45431955	45431955	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:45431955G>A	ENST00000361462.2	+	1	514	c.331G>A	c.(331-333)Gag>Aag	p.E111K	FAM179B_ENST00000382233.2_Missense_Mutation_p.E111K|FAM179B_ENST00000361577.3_Missense_Mutation_p.E111K			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	111							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GGATCCTTCTGAGGCCTTCCA	0.622000													24	71					0	0	0.740014	0	0
ABCC8	6833	broad.mit.edu	37	11	17414623	17414623	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:17414623C>A	ENST00000302539.4	-	39	4789	c.4664G>T	c.(4663-4665)gGt>gTt	p.G1555V	ABCC8_ENST00000389817.3_Missense_Mutation_p.G1554V	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1554	ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AAGGATGGCACCCCGCTTCAG	0.617000													9	25					7.48243e-07	8.36851e-07	0.335167	1	0
IL1RAP	3556	broad.mit.edu	37	3	190366314	190366314	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:190366314G>A	ENST00000412504.2	+	11	1785	c.1533G>A	c.(1531-1533)gtG>gtA	p.V511V	IL1RAP_ENST00000447382.1_Silent_p.V511V|IL1RAP_ENST00000317757.3_Intron|IL1RAP_ENST00000072516.3_Silent_p.V511V|IL1RAP_ENST00000443369.2_Intron|IL1RAP_ENST00000439062.1_Silent_p.V511V			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	511	TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		AAACGAAGGTGAAAGAGCTGA	0.502000													15	68					0	0	0.539581	0	0
TNFRSF10D	8793	broad.mit.edu	37	8	23004489	23004489	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:23004489C>T	ENST00000312584.3	-	4	561	c.467G>A	c.(466-468)cGg>cAg	p.R156Q		NM_003840.4	NP_003831.2	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	156					anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TCTACACGTCCGGCACATCTC	0.502000													7	44					0	0	0.335167	0	0
ATXN2L	11273	broad.mit.edu	37	16	28834730	28834730	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:28834730G>T	ENST00000336783.4	+	1	317	c.150G>T	c.(148-150)ggG>ggT	p.G50G	ATXN2L_ENST00000382686.4_Silent_p.G50G|ATXN2L_ENST00000340394.8_Silent_p.G50G|ATXN2L_ENST00000395547.2_Silent_p.G50G|ATXN2L_ENST00000564304.1_Silent_p.G50G|ATXN2L_ENST00000325215.6_Silent_p.G50G|ATXN2L_ENST00000570200.1_Silent_p.G50G	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	50	Pro-rich.					membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CTCCTCCCGGGCCTCCAGCGG	0.821000													2	2					0.00909568	0.00942845	0.150653	1	0
CPNE2	221184	broad.mit.edu	37	16	57157339	57157339	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:57157339A>G	ENST00000535318.2	+	11	1242	c.881A>G	c.(880-882)tAc>tGc	p.Y294C	CPNE2_ENST00000537605.1_Missense_Mutation_p.Y192C|CPNE2_ENST00000290776.8_Missense_Mutation_p.Y294C|CPNE2_ENST00000565874.1_Missense_Mutation_p.Y294C			Q96FN4	CPNE2_HUMAN	copine II	294										central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				AACCGAGACTACTCCTTCCTT	0.577000													63	72					0	0	0.870114	0	0
ANK2	287	broad.mit.edu	37	4	114278218	114278218	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:114278218A>G	ENST00000357077.4	+	38	8497	c.8444A>G	c.(8443-8445)cAa>cGa	p.Q2815R	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.Q2782R|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2782					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTAGCTCTCCAAGGCACTCAT	0.463000													30	36					0	0	0.750413	0	0
AADAT	51166	broad.mit.edu	37	4	170988519	170988519	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:170988519T>C	ENST00000337664.4	-	9	1197	c.921A>G	c.(919-921)ctA>ctG	p.L307L	AADAT_ENST00000509167.1_Silent_p.L311L|AADAT_ENST00000515480.1_Silent_p.L307L|AADAT_ENST00000353187.2_Silent_p.L307L	NM_016228.3	NP_057312.1	Q8N5Z0	AADAT_HUMAN	aminoadipate aminotransferase	307					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|pancreas(1)|stomach(1)	11		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCCATTCGTGTAGAAGCTGTG	0.343000													25	31					0	0	0.760397	0	0
NRXN2	9379	broad.mit.edu	37	11	64428312	64428312	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64428312G>A	ENST00000265459.6	-	10	2559	c.2098C>T	c.(2098-2100)Cgc>Tgc	p.R700C	NRXN2_ENST00000377551.1_Missense_Mutation_p.R700C|NRXN2_ENST00000496291.1_5'UTR|NRXN2_ENST00000377559.3_Missense_Mutation_p.R669C|NRXN2_ENST00000409571.1_Missense_Mutation_p.R693C	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	700	EGF-like 2.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CCCCCATTGCGACAGGGGGCA	0.647000													41	29					0	0	0.870114	0	0
UNC79	57578	broad.mit.edu	37	14	94004365	94004365	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:94004365G>C	ENST00000553484.1	+	12	1307	c.1153G>C	c.(1153-1155)Gtc>Ctc	p.V385L	UNC79_ENST00000555664.1_Missense_Mutation_p.V385L|UNC79_ENST00000256339.4_Missense_Mutation_p.V208L|UNC79_ENST00000393151.2_Missense_Mutation_p.V385L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	385						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AAGAGCAGTTGTCACCTGCTT	0.468000													23	22					0	0	0.681144	0	0
PTPRF	5792	broad.mit.edu	37	1	44086245	44086245	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:44086245G>T	ENST00000359947.4	+	31	5699	c.5359G>T	c.(5359-5361)Gcc>Tcc	p.A1787S	PTPRF_ENST00000422171.2_Missense_Mutation_p.A1146S|PTPRF_ENST00000372413.3_Missense_Mutation_p.A1778S|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000438120.1_Missense_Mutation_p.A1778S|PTPRF_ENST00000372414.3_Missense_Mutation_p.A1787S	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1787	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGTCACGGATGCCCGGGTGAG	0.552000													113	126					3.07415e-52	4.16973e-52	0.870114	1	0
MSGN1	343930	broad.mit.edu	37	2	17998252	17998252	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:17998252G>A	ENST00000281047.3	+	1	490	c.467G>A	c.(466-468)aGc>aAc	p.S156N		NM_001105569.1	NP_001099039.1	A6NI15	MSGN1_HUMAN	mesogenin 1	156	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCTGTCTACAGCCAGAGAGGC	0.587000													12	27					0	0	0.435327	0	0
ERBB3	2065	broad.mit.edu	37	12	56481649	56481649	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:56481649T>A	ENST00000267101.3	+	6	1124	c.684T>A	c.(682-684)caT>caA	p.H228Q	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.H169Q	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	228					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGTGCTGCCATGATGAGTGTG	0.537000													52	121					0	0	0.870114	0	0
NLRP8	126205	broad.mit.edu	37	19	56482062	56482062	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:56482062C>T	ENST00000291971.3	+	6	2605	c.2534C>T	c.(2533-2535)tCg>tTg	p.S845L	NLRP8_ENST00000590542.1_Splice_Site_p.S845L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	845						cytoplasm	ATP binding	p.S845L(2)		breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGAGGCTGTCGTAAGTCTCC	0.473000													66	94					0	0	0.870114	0	0
MUC17	140453	broad.mit.edu	37	7	100678782	100678782	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:100678782T>C	ENST00000306151.4	+	3	4149	c.4085T>C	c.(4084-4086)gTt>gCt	p.V1362A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1362	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAACTCCTGTTGACAACAGC	0.453000													169	238					0	0	0.870114	0	0
GABRG2	2566	broad.mit.edu	37	5	161569191	161569191	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:161569191T>C	ENST00000356592.3	+	7	1251	c.791T>C	c.(790-792)gTc>gCc	p.V264A	GABRG2_ENST00000393933.4_Missense_Mutation_p.V169A|GABRG2_ENST00000414552.2_Missense_Mutation_p.V304A|GABRG2_ENST00000361925.4_Missense_Mutation_p.V264A	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GTCATGTCTGTCTACTTTGAT	0.403000													24	144					0	0	0.740014	0	0
PODN	127435	broad.mit.edu	37	1	53540317	53540317	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:53540317A>G	ENST00000371500.3	+	6	874	c.533A>G	c.(532-534)aAt>aGt	p.N178S	PODN_ENST00000395871.2_Intron|PODN_ENST00000312553.5_Missense_Mutation_p.N197S|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	149					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ACCAACCTCAATTACCTGTAC	0.562000													50	192					0	0	0.870114	0	0
TCTN2	79867	broad.mit.edu	37	12	124158196	124158196	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:124158196G>T	ENST00000303372.5	+	4	430	c.302G>T	c.(301-303)gGt>gTt	p.G101V	TCTN2_ENST00000426174.2_Missense_Mutation_p.G100V	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	101					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGGAAGAGAGGTCTGGACTGG	0.433000													21	71					2.48779e-11	2.89675e-11	0.693898	1	0
SCG2	7857	broad.mit.edu	37	2	224462395	224462395	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:224462395C>G	ENST00000305409.2	-	2	1838	c.1606G>C	c.(1606-1608)Gac>Cac	p.D536H		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	536					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCCTGCAGGTCATCTTCAGAT	0.468000													19	10					0	0	0.624587	0	0
SRRM4	84530	broad.mit.edu	37	12	119568521	119568521	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:119568521G>A	ENST00000267260.4	+	8	1041	c.653G>A	c.(652-654)cGc>cAc	p.R218H	SRRM4_ENST00000537597.1_3'UTR	NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	218	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CAGAAGTCCCGCCGAAGGCAC	0.652000													11	10					0	0	0.361761	0	0
DNAJB13	374407	broad.mit.edu	37	11	73670624	73670624	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:73670624G>C	ENST00000339764.1	+	3	1009	c.258G>C	c.(256-258)tgG>tgC	p.W86C		NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	86					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					AGACCCCATGGACAACTGGTT	0.522000													73	23					0	0	0.870114	0	0
LIPE	3991	broad.mit.edu	37	19	42911490	42911490	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:42911490T>A	ENST00000244289.4	-	6	2249	c.1973A>T	c.(1972-1974)cAg>cTg	p.Q658L	LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	658					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				TCTGGAGGTCTGGGCCACAAA	0.687000													6	5					0	0	0.248553	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39913486	39913486	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:39913486G>A	ENST00000425673.1	+	16	2030	c.1705G>A	c.(1705-1707)Gaa>Aaa	p.E569K	PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.E598K|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.E539K|PLEKHG2_ENST00000409797.2_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	598					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGAGGAGGAGGAAGAGGAAGG	0.602000													5	12					0	0	0.184627	0	0
LRRC14B	389257	broad.mit.edu	37	5	192543	192543	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:192543C>A	ENST00000328278.3	+	1	918	c.890C>A	c.(889-891)aCg>aAg	p.T297K		NM_001080478.1	NP_001073947.1	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	297										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						AAGATCCCGACGCTGCTTGGG	0.657000													3	4					0.000602214	0.000634565	0.184627	1	0
HINFP	25988	broad.mit.edu	37	11	118997680	118997680	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:118997680G>A	ENST00000350777.2	+	2	89	c.26G>A	c.(25-27)cGa>cAa	p.R9Q	HINFP_ENST00000527354.1_Intron|HINFP_ENST00000527410.1_Missense_Mutation_p.R9Q	NM_001243259.1|NM_015517.4|NM_198971.2	NP_001230188.1|NP_056332.2|NP_945322.1	Q9BQA5	HINFP_HUMAN	histone H4 transcription factor	9					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						AAAGTTCCCCGAAAGGAGAAT	0.537000													80	46					0	0	0.870114	0	0
SNX32	254122	broad.mit.edu	37	11	65617466	65617466	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:65617466G>T	ENST00000308342.6	+	3	642	c.217G>T	c.(217-219)Gcc>Tcc	p.A73S		NM_152760.2	NP_689973.2	Q86XE0	SNX32_HUMAN	sorting nexin 32	73	PX.				cell communication|protein transport		phosphatidylinositol binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				READ - Rectum adenocarcinoma(159;0.171)		GCTGCATGATGCCTACGTGGA	0.632000													31	22					1.56738e-10	1.80851e-10	0.796494	1	0
TMEM132B	114795	broad.mit.edu	37	12	126135372	126135372	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:126135372G>T	ENST00000299308.3	+	7	1780	c.1772G>T	c.(1771-1773)gGc>gTc	p.G591V	TMEM132B_ENST00000535886.1_Missense_Mutation_p.G103V	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	591						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TACATGCTGGGCCCCGACTGG	0.597000													18	53					2.21704e-12	2.60527e-12	0.639603	1	0
CDC5L	988	broad.mit.edu	37	6	44361233	44361233	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:44361233G>A	ENST00000371477.3	+	4	661	c.362G>A	c.(361-363)cGa>cAa	p.R121Q		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	121					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GATGATCCACGAAAACTTAAA	0.408000													7	18					0	0	0.278610	0	0
WFDC3	140686	broad.mit.edu	37	20	44418583	44418583	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:44418583G>T	ENST00000243938.4	-	2	115	c.32C>A	c.(31-33)gCa>gAa	p.A11E	WFDC3_ENST00000372632.2_Missense_Mutation_p.A11E|WFDC3_ENST00000481847.1_Intron|WFDC3_ENST00000372630.2_Missense_Mutation_p.A11E	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	11						extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				AGCAAGAAGTGCCTTCAGAAG	0.483000													28	63					6.53348e-20	8.12701e-20	0.788014	1	0
RB1	5925	broad.mit.edu	37	13	48955538	48955538	+	Nonsense_Mutation	SNP	C	C	T	rs121913303		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:48955538C>T	ENST00000267163.4	+	17	1792	c.1654C>T	c.(1654-1656)Cga>Tga	p.R552*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	552	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)|p.R552*(5)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACATTTAGAACGATGTGAACA	0.323000	R552*(NCIH1048_LUNG)	6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			17	24					0	0	0.639603	0	0
PDE9A	5152	broad.mit.edu	37	21	44192566	44192566	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr21:44192566C>A	ENST00000291539.6	+	19	1764	c.1704C>A	c.(1702-1704)gaC>gaA	p.D568E	PDE9A_ENST00000349112.3_Missense_Mutation_p.D440E|PDE9A_ENST00000398232.3_Missense_Mutation_p.D501E|PDE9A_ENST00000398229.3_Missense_Mutation_p.D434E|PDE9A_ENST00000335512.4_Missense_Mutation_p.D508E|PDE9A_ENST00000380328.2_Missense_Mutation_p.D515E|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398225.3_Missense_Mutation_p.D527E|PDE9A_ENST00000335440.6_Missense_Mutation_p.D466E|PDE9A_ENST00000398234.3_Missense_Mutation_p.D467E|PDE9A_ENST00000398236.3_Missense_Mutation_p.D482E|PDE9A_ENST00000398224.3_Missense_Mutation_p.D441E|PDE9A_ENST00000539837.1_Missense_Mutation_p.D440E|PDE9A_ENST00000398227.3_Missense_Mutation_p.D408E|PDE9A_ENST00000328862.6_Missense_Mutation_p.D542E	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	568					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						AGAAGACTGACAGCTTGACGT	0.532000													5	18					2.0095e-06	2.21828e-06	0.248553	1	0
ZNF302	55900	broad.mit.edu	37	19	35175840	35175840	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:35175840C>G	ENST00000505242.1	+	5	1392	c.898C>G	c.(898-900)Ctc>Gtc	p.L300V	ZNF302_ENST00000446502.2_Missense_Mutation_p.L344V|ZNF302_ENST00000423823.2_Missense_Mutation_p.L300V|ZNF302_ENST00000505365.2_3'UTR|ZNF302_ENST00000457781.2_Missense_Mutation_p.L300V			Q9NR11	ZN302_HUMAN	zinc finger protein 302	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGTGTCCCTTCTCATTCAGCA	0.423000													12	50					0	0	0.457914	0	0
GATA4	2626	broad.mit.edu	37	8	11615912	11615912	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:11615912G>A	ENST00000335135.4	+	7	1815	c.1257G>A	c.(1255-1257)caG>caA	p.Q419Q	GATA4_ENST00000528712.1_Silent_p.Q213Q|GATA4_ENST00000532059.1_Silent_p.Q420Q	NM_002052.3	NP_002043.2	P43694	GATA4_HUMAN	GATA binding protein 4	419					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(10)	13	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		AGTCTCCACAGACCAGCTCCA	0.587000													27	47					0	0	0.769981	0	0
LRRC52	440699	broad.mit.edu	37	1	165532872	165532872	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:165532872C>T	ENST00000294818.1	+	2	1043	c.753C>T	c.(751-753)atC>atT	p.I251I	RP11-280O1.2_ENST00000438275.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000421273.1_RNA	NM_001005214.3	NP_001005214.2	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52	251						integral to membrane				NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)	18	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TGCTGCTCATCGGCTTCTGCA	0.587000													13	35					0	0	0.479597	0	0
KLHL13	90293	broad.mit.edu	37	X	117054334	117054334	+	Splice_Site	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:117054334C>A	ENST00000371876.1	-	2	2509		c.e2-1		KLHL13_ENST00000371882.1_Splice_Site|KLHL13_ENST00000539496.1_Splice_Site|KLHL13_ENST00000469946.1_Splice_Site|KLHL13_ENST00000545703.1_Splice_Site|KLHL13_ENST00000262820.3_Splice_Site|KLHL13_ENST00000540167.1_Splice_Site|KLHL13_ENST00000371878.1_Splice_Site|KLHL13_ENST00000541812.1_Splice_Site			Q9P2N7	KLH13_HUMAN	kelch-like family member 13						cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGTCAAAGCCCTACAACAAGA	0.408000													46	49					3.94638e-17	4.81496e-17	0.870114	1	0
ATF2	1386	broad.mit.edu	37	2	175979453	175979453	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:175979453T>C	ENST00000264110.2	-	8	889	c.591A>G	c.(589-591)gtA>gtG	p.V197V	ATF2_ENST00000538946.1_Silent_p.V179V|ATF2_ENST00000426833.3_Silent_p.V179V|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000487334.2_Silent_p.V179V|ATF2_ENST00000345739.5_Silent_p.V139V|ATF2_ENST00000392544.1_Silent_p.V197V|ATF2_ENST00000409635.1_Silent_p.V139V|ATF2_ENST00000392543.2_Intron|ATF2_ENST00000409437.1_Intron|ATF2_ENST00000409833.1_Silent_p.V197V	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	197					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			CCTGGGTGATTACAGTACTTG	0.403000													118	93					0	0	0.870114	0	0
MFSD11	79157	broad.mit.edu	37	17	74740413	74740413	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:74740413G>C	ENST00000588460.1	+	7	2548	c.506G>C	c.(505-507)cGa>cCa	p.R169P	MFSD11_ENST00000355954.3_Missense_Mutation_p.R117P|MFSD11_ENST00000586622.1_Missense_Mutation_p.R169P|MFSD11_ENST00000590514.1_Missense_Mutation_p.R169P|MFSD11_ENST00000336509.4_Missense_Mutation_p.R169P|MFSD11_ENST00000593181.1_Missense_Mutation_p.R117P	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	169						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						GAGAGTGACCGAAGAACAGTG	0.413000													25	48					0	0	0.796494	0	0
CCDC108	255101	broad.mit.edu	37	2	219900359	219900359	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:219900359G>A	ENST00000341552.5	-	5	468	c.385C>T	c.(385-387)Cac>Tac	p.H129Y	CCDC108_ENST00000441968.1_Missense_Mutation_p.H129Y|CCDC108_ENST00000409865.3_Missense_Mutation_p.H118Y|CCDC108_ENST00000295729.2_Missense_Mutation_p.H64Y|CCDC108_ENST00000453220.1_Missense_Mutation_p.H129Y|CCDC108_ENST00000410037.1_Missense_Mutation_p.H64Y|CCDC108_ENST00000324264.6_Missense_Mutation_p.H64Y	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	129				H -> R (in Ref. 1; BAC86878).		integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTTGGGGAGTGCATCTGAGTG	0.567000													63	16					0	0	0.870114	0	0
EHBP1	23301	broad.mit.edu	37	2	63176182	63176182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:63176182G>A	ENST00000263991.5	+	14	2788	c.2306G>A	c.(2305-2307)aGt>aAt	p.S769N	EHBP1_ENST00000354487.3_Missense_Mutation_p.S734N|EHBP1_ENST00000405289.1_Missense_Mutation_p.S734N|EHBP1_ENST00000431489.1_Missense_Mutation_p.S734N|EHBP1_ENST00000405015.3_Missense_Mutation_p.S734N	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	769						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TACTCATATAGTAGAGATCTA	0.373000													20	13					0	0	0.592651	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	17					0	0	0.827153	0	0
SAC3D1	29901	broad.mit.edu	37	11	64811717	64811717	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64811717G>A	ENST00000398846.1	+	2	984	c.595G>A	c.(595-597)Gag>Aag	p.E199K	SAC3D1_ENST00000531072.1_Missense_Mutation_p.E199K|SAC3D1_ENST00000530213.1_3'UTR	NM_013299.3	NP_037431.3			SAC3 domain containing 1											endometrium(2)|lung(1)	3						AGCCCTGCATGAGGTTCTACA	0.642000													14	56					0	0	0.479597	0	0
RGS7BP	401190	broad.mit.edu	37	5	63871635	63871635	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:63871635C>T	ENST00000334025.2	+	3	693	c.367C>T	c.(367-369)Cgg>Tgg	p.R123W	RGS7BP_ENST00000508162.1_3'UTR	NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	123					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		AGAAATCTGTCGGCTTTACAT	0.433000													25	13					0	0	0.717897	0	0
CES2	8824	broad.mit.edu	37	16	66969416	66969416	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:66969416C>G	ENST00000317091.4	+	1	1054	c.70C>G	c.(70-72)Ccc>Gcc	p.P24A	CES2_ENST00000417689.1_Missense_Mutation_p.P24A	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	0					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCCGCTGACTCCCTGCCCAGT	0.662000													46	165					0	0	0.870114	0	0
BANP	54971	broad.mit.edu	37	16	88008777	88008777	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:88008777G>C	ENST00000393207.1	+	2	277	c.56G>C	c.(55-57)aGc>aCc	p.S19T	BANP_ENST00000355022.4_Missense_Mutation_p.S19T|BANP_ENST00000355163.5_Missense_Mutation_p.S19T|BANP_ENST00000286122.7_Missense_Mutation_p.S19T|BANP_ENST00000538234.1_Missense_Mutation_p.S19T|BANP_ENST00000479780.2_Missense_Mutation_p.S19T|BANP_ENST00000393208.2_Missense_Mutation_p.S19T	NM_001173543.1	NP_001167014.1	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein	19					cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.00551)		GAAGACCTGAGCCCTGACCAC	0.473000													26	50					0	0	0.779181	0	0
MYBPC2	4606	broad.mit.edu	37	19	50961863	50961863	+	Silent	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:50961863C>G	ENST00000357701.5	+	21	2409	c.2358C>G	c.(2356-2358)gcC>gcG	p.A786A		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	786	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGGTCCCTGCCAACACCGAGC	0.657000													14	34					0	0	0.520397	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33096357	33096357	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:33096357T>C	ENST00000267068.3	-	4	1599	c.1435A>G	c.(1435-1437)Aat>Gat	p.N479D	N4BP2L2_ENST00000504114.1_Missense_Mutation_p.N35D|N4BP2L2_ENST00000357505.6_Missense_Mutation_p.N35D|N4BP2L2_ENST00000399396.3_Missense_Mutation_p.N50D|N4BP2L2_ENST00000446957.2_Missense_Mutation_p.N479D	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	479										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GCTTGTATATTAGTGTTATCT	0.254000													51	68					0	0	0.870114	0	0
MACC1	346389	broad.mit.edu	37	7	20199459	20199459	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:20199459C>T	ENST00000400331.5	-	5	833	c.525G>A	c.(523-525)cgG>cgA	p.R175R	MACC1_ENST00000332878.4_Silent_p.R175R|MACC1_ENST00000589011.1_Silent_p.R175R	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	175					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						TATAAGCCTCCCGATCATTTT	0.468000													8	68					0	0	0.307466	0	0
SYNE1	23345	broad.mit.edu	37	6	152464820	152464820	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:152464820C>T	ENST00000367255.5	-	138	25658	c.25057G>A	c.(25057-25059)Gaa>Aaa	p.E8353K	SYNE1_ENST00000539504.1_Missense_Mutation_p.E508K|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000341594.5_Missense_Mutation_p.E7965K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E8353K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E8305K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E8305K|SYNE1_ENST00000356820.4_Missense_Mutation_p.E2877K|SYNE1_ENST00000354674.4_Missense_Mutation_p.E531K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8353					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGATATTTTCGGTTTGCTGT	0.532000										HNSCC(10;0.0054)			19	52					0	0	0.608945	0	0
SSH2	85464	broad.mit.edu	37	17	27959241	27959241	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:27959241G>T	ENST00000269033.3	-	15	3041	c.2890C>A	c.(2890-2892)Cac>Aac	p.H964N	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.H991N	NM_001282129.1|NM_033389.2	NP_001269058.1|NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	964					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCTGGCAAGTGGTCAAACTCC	0.547000													23	19					1.64293e-13	1.9577e-13	0.654019	1	0
PAK3	5063	broad.mit.edu	37	X	110388131	110388131	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:110388131G>C	ENST00000519681.1	+	7	762	c.320G>C	c.(319-321)aGt>aCt	p.S107T	PAK3_ENST00000360648.4_Missense_Mutation_p.S107T|PAK3_ENST00000518291.1_Missense_Mutation_p.S107T|PAK3_ENST00000425146.1_Intron|PAK3_ENST00000446737.1_Intron|PAK3_ENST00000262836.4_Intron|PAK3_ENST00000417227.1_Missense_Mutation_p.S107T|PAK3_ENST00000372010.1_Intron|PAK3_ENST00000372007.5_Intron			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	99	Autoregulatory region (By similarity).|GTPase-binding (By similarity).|Linker.			PE -> SL (in Ref. 2).	multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						GTCGCTTCAAGTCAATCAGAG	0.388000										TSP Lung(19;0.15)			7	5					0	0	0.335167	0	0
OR10T2	128360	broad.mit.edu	37	1	158369175	158369175	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:158369175G>A	ENST00000334438.1	-	1	81	c.82C>T	c.(82-84)Ctt>Ttt	p.L28F		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L28F(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					ATGACAAAAAGCAGCAGCTGG	0.488000													6	27					0	0	0.278610	0	0
FMNL2	114793	broad.mit.edu	37	2	153476122	153476122	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:153476122G>C	ENST00000288670.9	+	15	2094	c.1727G>C	c.(1726-1728)gGc>gCc	p.G576A	FMNL2_ENST00000475377.2_5'UTR	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	576	Pro-rich.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						cctcTCCCAGGCCCTGCAGCT	0.642000													7	15					0	0	0.278610	0	0
IFI16	3428	broad.mit.edu	37	1	158986391	158986391	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:158986391G>T	ENST00000295809.7	+	4	705	c.450G>T	c.(448-450)caG>caT	p.Q150H	IFI16_ENST00000448393.2_Missense_Mutation_p.Q150H|IFI16_ENST00000340979.6_Missense_Mutation_p.Q150H|IFI16_ENST00000430894.2_Intron|IFI16_ENST00000368131.4_Missense_Mutation_p.Q150H|IFI16_ENST00000368132.3_Missense_Mutation_p.Q150H|IFI16_ENST00000359709.3_Intron			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	150	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					AACAGACTCAGCCTCCCTCTC	0.502000													5	36					0.014758	0.015236	0.184627	1	0
PMEL	6490	broad.mit.edu	37	12	56355112	56355112	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:56355112G>T	ENST00000548747.1	-	3	985	c.323C>A	c.(322-324)aCc>aAc	p.T108N	PMEL_ENST00000539511.1_Intron|PMEL_ENST00000552882.1_Missense_Mutation_p.T108N|PMEL_ENST00000550447.1_Missense_Mutation_p.T71N|PMEL_ENST00000449260.2_Missense_Mutation_p.T108N|PMEL_ENST00000536427.1_Missense_Mutation_p.T108N|PMEL_ENST00000548689.1_5'UTR|PMEL_ENST00000550464.1_Intron|PMEL_ENST00000548493.1_Missense_Mutation_p.T108N|PMEL_ENST00000360714.4_Missense_Mutation_p.T108N			P40967	PMEL_HUMAN	premelanosome protein	108					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ATTGATGATGGTATTGTTGAC	0.488000													32	19					9.8876e-21	1.24204e-20	0.804634	1	0
WISP3	8838	broad.mit.edu	37	6	112382385	112382385	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:112382385G>T	ENST00000361714.1	+	2	339	c.294G>T	c.(292-294)aaG>aaT	p.K98N	WISP3_ENST00000368666.2_Missense_Mutation_p.K80N|WISP3_ENST00000604763.1_Missense_Mutation_p.K80N|WISP3_ENST00000368663.3_Missense_Mutation_p.K58N|WISP3_ENST00000230529.5_Missense_Mutation_p.K80N			O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	80	IGFBP N-terminal.				cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding	p.K98N(1)		breast(1)|central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	13		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TCTGTGCCAAGCAACCAGGGG	0.537000													54	21					6.4685e-43	8.54646e-43	0.870114	1	0
EPHB1	2047	broad.mit.edu	37	3	134968233	134968233	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:134968233G>A	ENST00000398015.3	+	15	3116	c.2746G>A	c.(2746-2748)Gtg>Atg	p.V916M	EPHB1_ENST00000493838.1_Missense_Mutation_p.V477M	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	916	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CTTTACCACCGTGGATGACTG	0.587000													41	33					0	0	0.847076	0	0
GPRC6A	222545	broad.mit.edu	37	6	117128326	117128326	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:117128326C>T	ENST00000310357.3	-	3	563	c.542G>A	c.(541-543)cGc>cAc	p.R181H	GPRC6A_ENST00000368549.3_Missense_Mutation_p.R181H|GPRC6A_ENST00000530250.1_Missense_Mutation_p.R181H	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	181					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGAAGGAAAGCGAATTTTGTC	0.398000													44	26					0	0	0.870114	0	0
USP32	84669	broad.mit.edu	37	17	58348774	58348774	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:58348774G>A	ENST00000300896.4	-	6	834	c.640C>T	c.(640-642)Cga>Tga	p.R214*	USP32_ENST00000393003.3_Nonsense_Mutation_p.R214*	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	214					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AAATCAAATCGTCCAGTCCGG	0.398000													3	60					0	0	0.150653	0	0
DMD	1756	broad.mit.edu	37	X	32383166	32383166	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:32383166G>T	ENST00000357033.4	-	35	5202	c.4996C>A	c.(4996-4998)Cga>Aga	p.R1666R	DMD_ENST00000378677.2_Silent_p.R1662R	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1666	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTCTGCTCGGGAGGTGACA	0.428000													49	44					3.30226e-22	4.25291e-22	0.870114	1	0
AUH	549	broad.mit.edu	37	9	94118381	94118381	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:94118381G>C	ENST00000375731.4	-	2	342	c.319C>G	c.(319-321)Ctt>Gtt	p.L107V	AUH_ENST00000422391.2_Missense_Mutation_p.L107V|AUH_ENST00000303617.5_Missense_Mutation_p.L107V|AUH_ENST00000478465.1_5'UTR	NM_001698.2	NP_001689.1	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-CoA hydratase	107	RNA-binding.				branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						ATTTTTATAAGATTTTTACTG	0.289000													4	17					0	0	0.150653	0	0
FAT1	2195	broad.mit.edu	37	4	187525600	187525600	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:187525600C>A	ENST00000441802.2	-	18	10688	c.10479G>T	c.(10477-10479)ccG>ccT	p.P3493P		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3493	Cadherin 32.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GGACTCCTTGCGGGTTAACTT	0.433000										HNSCC(5;0.00058)			12	31					1.3612e-06	1.51575e-06	0.479597	1	0
ZNF197	10168	broad.mit.edu	37	3	44685245	44685245	+	Nonsense_Mutation	SNP	G	G	T	rs61751651		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:44685245G>T	ENST00000396058.1	+	5	2790	c.2623G>T	c.(2623-2625)Gaa>Taa	p.E875*	ZNF197_ENST00000383744.4_Intron|RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000344387.4_Nonsense_Mutation_p.E875*			O14709	ZN197_HUMAN	zinc finger protein 197	875					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AAAAACCTACGAATGTCATGT	0.383000													22	44					7.33532e-06	7.99362e-06	0.667858	1	0
PRR5L	79899	broad.mit.edu	37	11	36422827	36422827	+	Silent	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:36422827C>A	ENST00000378867.3	+	3	511	c.156C>A	c.(154-156)gcC>gcA	p.A52A	PRR5L_ENST00000389693.3_Intron|PRR5L_ENST00000311599.5_Silent_p.A26A|PRR5L_ENST00000527487.1_Silent_p.A52A|PRR5L_ENST00000530639.1_Silent_p.A52A	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	52										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						CCAGCTCAGCCTGGAACAGGT	0.652000													3	11					0.115264	0.116175	0.115264	1	0
PRPF6	24148	broad.mit.edu	37	20	62664245	62664245	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62664245G>T	ENST00000535781.1	+	20	2716	c.2605G>T	c.(2605-2607)Ggg>Tgg	p.G869W	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	909					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GCCTCGGCATGGGGAGCTGTG	0.642000													25	23					7.92952e-12	9.27536e-12	0.667858	1	0
GTSF1	121355	broad.mit.edu	37	12	54854248	54854248	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:54854248T>C	ENST00000552397.1	-	7	1296	c.400A>G	c.(400-402)Agc>Ggc	p.S134G	GTSF1_ENST00000305879.5_Missense_Mutation_p.S134G|RP11-753H16.3_ENST00000550474.1_RNA|GTSF1_ENST00000552395.1_5'UTR|RP11-753H16.5_ENST00000552785.1_RNA			Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	134							metal ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(1001;0.00452)				ACTATGTTGCTCGCAGGGCTG	0.413000													18	27					0	0	0.575678	0	0
NOA1	84273	broad.mit.edu	37	4	57842717	57842717	+	Silent	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:57842717G>T	ENST00000264230.4	-	1	2272	c.1035C>A	c.(1033-1035)ggC>ggA	p.G345G		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	345							GTP binding										CGTTGGTGGCGCCCACTAAGT	0.607000													14	40					1.52009e-12	1.79455e-12	0.479597	1	0
WHSC1	7468	broad.mit.edu	37	4	1936889	1936889	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:1936889A>G	ENST00000503128.1	+	7	1781	c.1574A>G	c.(1573-1575)aAa>aGa	p.K525R	WHSC1_ENST00000514045.1_Missense_Mutation_p.K525R|WHSC1_ENST00000420906.2_Missense_Mutation_p.K525R|WHSC1_ENST00000382892.2_Missense_Mutation_p.K525R|WHSC1_ENST00000382891.5_Missense_Mutation_p.K525R|WHSC1_ENST00000382895.3_Missense_Mutation_p.K525R|WHSC1_ENST00000398261.1_Missense_Mutation_p.K525R|WHSC1_ENST00000508803.1_Missense_Mutation_p.K525R			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	525					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AATGGGAAAAAAAGAAACCAC	0.468000			T	IGH@	MM								6	19					0	0	0.217242	0	0
FAM83H	286077	broad.mit.edu	37	8	144810312	144810312	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:144810312T>G	ENST00000388913.3	-	5	1444	c.1319A>C	c.(1318-1320)gAc>gCc	p.D440A		NM_198488.3	NP_940890	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	440					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAAGCGGAAGTCGTCGCCGTG	0.697000													5	15					0	0	0.184627	0	0
ADAM32	203102	broad.mit.edu	37	8	39111966	39111966	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:39111966C>A	ENST00000379907.4	+	18	2063	c.1936C>A	c.(1936-1938)Cca>Aca	p.P646T	ADAM32_ENST00000437682.2_Missense_Mutation_p.P547T|ADAM32_ENST00000519315.1_Missense_Mutation_p.P540T	NM_145004.5	NP_659441	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	646	EGF-like.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CCATTGTTCGCCAGGCTATAA	0.363000													6	3					0.00621372	0.00649384	0.335167	1	0
IL2RB	3560	broad.mit.edu	37	22	37524836	37524836	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:37524836G>T	ENST00000216223.5	-	10	1154	c.956C>A	c.(955-957)gCa>gAa	p.A319E		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	319					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GATCTCAGGTGCCAGGCCGCC	0.627000													14	37					3.99206e-14	4.80177e-14	0.557998	1	0
RP1L1	94137	broad.mit.edu	37	8	10469938	10469938	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:10469938C>T	ENST00000382483.3	-	4	1893	c.1670G>A	c.(1669-1671)gGc>gAc	p.G557D		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	557					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTTGCCTTGCCTGGACAGCC	0.657000													24	39					0	0	0.681144	0	0
GRHL3	57822	broad.mit.edu	37	1	24668758	24668758	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:24668758G>T	ENST00000361548.4	+	9	1431	c.1201G>T	c.(1201-1203)Gac>Tac	p.D401Y	GRHL3_ENST00000236255.4_Missense_Mutation_p.D406Y|GRHL3_ENST00000356046.2_Missense_Mutation_p.D355Y|GRHL3_ENST00000342072.4_Missense_Mutation_p.D308Y|GRHL3_ENST00000350501.5_Missense_Mutation_p.D401Y	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	401					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATCTTCTGTGACAAGGTGGC	0.587000													41	30					2.43468e-25	3.16757e-25	0.870114	1	0
OR4C15	81309	broad.mit.edu	37	11	55322269	55322269	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:55322269G>T	ENST00000314644.2	+	1	487	c.487G>T	c.(487-489)Gtg>Ttg	p.V163L		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CTTTGCTGGGGTGGAGGTGAT	0.473000										HNSCC(20;0.049)			19	124					6.21321e-17	7.54461e-17	0.639603	1	0
ATP5G1	516	broad.mit.edu	37	17	46971758	46971758	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:46971758A>G	ENST00000393366.2	+	3	167	c.64A>G	c.(64-66)Atc>Gtc	p.I22V	RP11-463M16.4_ENST00000508743.1_RNA|ATP5G1_ENST00000503641.1_Missense_Mutation_p.I22V|ATP5G1_ENST00000506855.1_Intron|ATP5G1_ENST00000355938.5_Missense_Mutation_p.I22V|ATP5G1_ENST00000514808.1_Missense_Mutation_p.I22V|ATP5G1_ENST00000513781.1_3'UTR	NM_005175.2	NP_005166.1	P05496	AT5G1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	22					ATP hydrolysis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding			liver(1)|lung(1)	2						CAGGGGTCTAATCAGGCCTGT	0.443000													50	125					0	0	0.870114	0	0
ABLIM2	84448	broad.mit.edu	37	4	8029554	8029554	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:8029554C>A	ENST00000447017.2	-	12	1218	c.1199G>T	c.(1198-1200)tGc>tTc	p.C400F	ABLIM2_ENST00000361737.5_Intron|ABLIM2_ENST00000546334.1_Intron|ABLIM2_ENST00000341937.5_Intron|ABLIM2_ENST00000296372.8_Intron|ABLIM2_ENST00000428004.2_Intron|ABLIM2_ENST00000361581.5_Intron|ABLIM2_ENST00000515079.1_5'UTR|ABLIM2_ENST00000545242.1_Intron|ABLIM2_ENST00000318888.4_Intron|ABLIM2_ENST00000407564.3_Intron|ABLIM2_ENST00000505872.1_Intron|ABLIM2_ENST00000514025.1_Intron	NM_001130083.1	NP_001123555.1	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	400					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						CAGGGAGAGGCAGCTACTGGT	0.557000													10	35					0.000308642	0.000326571	0.479597	1	0
MYO18B	84700	broad.mit.edu	37	22	26173598	26173598	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:26173598G>T	ENST00000335473.7	+	8	2168	c.1918G>T	c.(1918-1920)Gca>Tca	p.A640S	MYO18B_ENST00000407587.2_Missense_Mutation_p.A640S|MYO18B_ENST00000536101.1_Missense_Mutation_p.A640S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	640	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGGCTCCATGGCACAGCGGGC	0.647000													6	30					1.12685e-05	1.21243e-05	0.307466	1	0
TBC1D8	11138	broad.mit.edu	37	2	101624437	101624437	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:101624437G>C	ENST00000409318.1	-	20	3444	c.3314C>G	c.(3313-3315)gCt>gGt	p.A1105G	RPL31_ENST00000409650.1_Intron|RPL31_ENST00000409028.4_Intron|TBC1D8_ENST00000376840.4_Missense_Mutation_p.A1090G|RPL31_ENST00000409038.1_Intron	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	1090					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						CAGAAGTGAAGCTAAAATATG	0.448000													4	37					0	0	0.150653	0	0
TBC1D8	11138	broad.mit.edu	37	2	101624308	101624308	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:101624308G>A	ENST00000409318.1	-	20	3573	c.3443C>T	c.(3442-3444)tCt>tTt	p.S1148F	RPL31_ENST00000409650.1_Intron|RPL31_ENST00000409028.4_Intron|TBC1D8_ENST00000376840.4_Missense_Mutation_p.S1133F|RPL31_ENST00000409038.1_Intron	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	1133					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						CTTAAGTTCAGATTGTGATTG	0.423000													33	142					0	0	0.840704	0	0
BANK1	55024	broad.mit.edu	37	4	102946511	102946511	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:102946511C>G	ENST00000504592.1	+	13	1812	c.1394C>G	c.(1393-1395)tCt>tGt	p.S465C	BANK1_ENST00000444316.2_Missense_Mutation_p.S450C|BANK1_ENST00000510950.1_3'UTR|BANK1_ENST00000508653.1_Missense_Mutation_p.S347C|BANK1_ENST00000322953.4_Missense_Mutation_p.S480C|RP11-498M5.2_ENST00000505091.1_RNA|BANK1_ENST00000428908.1_Missense_Mutation_p.S347C			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	480					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGTGAGAGTTCTGAAGACCAG	0.493000													14	56					0	0	0.520397	0	0
DIDO1	11083	broad.mit.edu	37	20	61513072	61513072	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:61513072C>G	ENST00000266070.4	-	16	4561	c.4236G>C	c.(4234-4236)agG>agC	p.R1412S	DIDO1_ENST00000395343.1_Missense_Mutation_p.R1412S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1412					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTTCAGGAGCCCTTTCCACCT	0.612000													69	70					0	0	0.870114	0	0
MAP3K4	4216	broad.mit.edu	37	6	161530934	161530934	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:161530934C>A	ENST00000392142.4	+	23	4532	c.4384C>A	c.(4384-4386)Cgt>Agt	p.R1462S	MAP3K4_ENST00000366920.2_Missense_Mutation_p.R1458S|MAP3K4_ENST00000348824.7_Missense_Mutation_p.R1408S|MAP3K4_ENST00000366919.2_Missense_Mutation_p.R1412S	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1462	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding	p.R1462C(1)|p.R1461C(1)		breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CATAGTCCACCGTGACATTAA	0.552000													3	70					0.150653	0.151247	0.150653	1	0
SGSM3	27352	broad.mit.edu	37	22	40804819	40804819	+	Silent	SNP	C	C	T	rs140197200		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:40804819C>T	ENST00000248929.9	+	18	2064	c.1875C>T	c.(1873-1875)gtC>gtT	p.V625V	SGSM3_ENST00000454798.2_Silent_p.V558V	NM_015705.4	NP_056520.2	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	625	RUN.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)	19						ATGGCAAAGTCCTGACCCCGG	0.652000													15	49					0	0	0.608945	0	0
C2orf44	80304	broad.mit.edu	37	2	24254029	24254029	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:24254029G>A	ENST00000295148.4	-	4	1997	c.1940C>T	c.(1939-1941)tCc>tTc	p.S647F	C2orf44_ENST00000406895.3_Missense_Mutation_p.P608S	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	647							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATCCAGTGGGAATCTGCAAA	0.363000			T	ALK	NSCLC								7	15					0	0	0.248553	0	0
NELL1	4745	broad.mit.edu	37	11	20940871	20940871	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:20940871G>C	ENST00000298925.5	+	8	987	c.834G>C	c.(832-834)atG>atC	p.M278I	NELL1_ENST00000532434.1_Missense_Mutation_p.M250I|NELL1_ENST00000325319.5_Missense_Mutation_p.M193I|NELL1_ENST00000357134.5_Missense_Mutation_p.M250I			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	250	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TGGCCAAGATGACTGCAAAAG	0.328000													28	40					0	0	0.788014	0	0
ATP1A2	477	broad.mit.edu	37	1	160109741	160109741	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:160109741G>A	ENST00000361216.3	+	22	3090	c.3001G>A	c.(3001-3003)Gtc>Atc	p.V1001I	ATP1A2_ENST00000392233.3_Missense_Mutation_p.V990I	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1001					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTATGATGAGGTCCGAAAGCT	0.582000													33	68					0	0	0.859065	0	0
PLD3	23646	broad.mit.edu	37	19	40882622	40882622	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:40882622G>C	ENST00000409587.1	+	11	1523	c.1126G>C	c.(1126-1128)Gcc>Ccc	p.A376P	PLD3_ENST00000409735.4_Missense_Mutation_p.A376P|PLD3_ENST00000409419.1_Missense_Mutation_p.A376P|PLD3_ENST00000356508.5_Missense_Mutation_p.A376P|PLD3_ENST00000409281.1_Missense_Mutation_p.A376P			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	376					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			ATCCATGCGGGCCTTCCTGCT	0.652000													43	53					0	0	0.870114	0	0
GGT3P	2679	broad.mit.edu	37	22	18778612	18778612	+	RNA	SNP	C	C	T	rs1055042	by1000genomes	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:18778612C>T	ENST00000412448.1	-	0	793																											GCGGCCACGGCAGCCCTGGTG	0.637000													3	24					0	0	0.150653	0	0
UNC45A	55898	broad.mit.edu	37	15	91491883	91491883	+	Splice_Site	SNP	G	G	A	rs146010728	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:91491883G>A	ENST00000394275.2	+	16	2527		c.e16-1		UNC45A_ENST00000418476.2_Splice_Site	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)						cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TGTCCTGGCAGTTGGAGGAGA	0.602000													3	65					0	0	0.150653	0	0
ACAT1	38	broad.mit.edu	37	11	108009666	108009666	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:108009666T>C	ENST00000265838.4	+	6	568	c.477T>C	c.(475-477)gtT>gtC	p.V159V		NM_000019.3	NP_000010.1	P24752	THIL_HUMAN	acetyl-CoA acetyltransferase 1	159					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|prostate(2)	10		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	TGTCCAATGTTCCATATGTAA	0.398000													54	171					0	0	0.870114	0	0
MAP3K14	9020	broad.mit.edu	37	17	43351496	43351496	+	RNA	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:43351496C>G	ENST00000344686.2	-	0	1651							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TTACCTTTGACGTCCCCATGC	0.617000													3	3					0	0	0.150653	0	0
LRIT1	26103	broad.mit.edu	37	10	85997383	85997383	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:85997383G>A	ENST00000372105.3	-	2	203	c.182C>T	c.(181-183)aCc>aTc	p.T61I		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	61						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						CAGTCTGGAGGTGTCCGGGGG	0.662000													44	9					0	0	0.870114	0	0
CDK8	1024	broad.mit.edu	37	13	26828866	26828866	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:26828866G>T	ENST00000381527.3	+	1	591	c.88G>T	c.(88-90)Ggc>Tgc	p.G30C	CDK8_ENST00000536792.1_Missense_Mutation_p.G30C	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	30	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGTTGGCCGAGGCACTTATGG	0.592000													16	21					5.3912e-06	5.90024e-06	0.539581	1	0
JMJD7	100137047	broad.mit.edu	37	15	42129135	42129135	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:42129135G>A	ENST00000397299.4	+	7	899	c.859G>A	c.(859-861)Gca>Aca	p.A287T	JMJD7-PLA2G4B_ENST00000342159.4_Intron|JMJD7-PLA2G4B_ENST00000382448.4_Intron|JMJD7-PLA2G4B_ENST00000476036.1_Intron|JMJD7_ENST00000408047.1_Missense_Mutation_p.A188T|PLA2G4B_ENST00000542534.2_Intron	NM_001114632.1	NP_001108104.1			jumonji domain containing 7											NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)	8						GGGCTGCATCGCAGGTGAAGA	0.667000													3	40					0	0	0.115264	0	0
ZBTB45	84878	broad.mit.edu	37	19	59028486	59028486	+	Silent	SNP	T	T	C			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:59028486T>C	ENST00000594051.1	-	2	1035	c.555A>G	c.(553-555)ccA>ccG	p.P185P	ZBTB45_ENST00000354590.3_Silent_p.P185P|ZBTB45_ENST00000600990.1_Silent_p.P185P			Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	185	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|urinary_tract(1)	11		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		TGGCAGGTGTTGGGGGCGCTG	0.692000											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	36					0	0	0.769981	0	0
SHROOM2	357	broad.mit.edu	37	X	9900619	9900619	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:9900619C>T	ENST00000380913.3	+	6	3386	c.3296C>T	c.(3295-3297)cCt>cTt	p.P1099L	SHROOM2_ENST00000418909.2_5'UTR|SHROOM2_ENST00000493668.1_3'UTR	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1099					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				ACGCCATCCCCTGCGTCCCTG	0.692000													6	52					0	0	0.248553	0	0
PLAT	5327	broad.mit.edu	37	8	42050684	42050684	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:42050684C>G	ENST00000220809.4	-	2	276	c.20G>C	c.(19-21)gGg>gCg	p.G7A	PLAT_ENST00000429710.2_Missense_Mutation_p.G7A|PLAT_ENST00000270189.6_Missense_Mutation_p.G7A|PLAT_ENST00000524009.1_Missense_Mutation_p.G7A|PLAT_ENST00000429089.2_Missense_Mutation_p.G7A|PLAT_ENST00000352041.3_Missense_Mutation_p.G7A|PLAT_ENST00000519510.1_Missense_Mutation_p.G7A	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	7					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACAGCAGAGCCCTCTCTTCAT	0.547000													12	28					0	0	0.479597	0	0
GGT3P	2679	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													3	27					0	0	0.115264	0	0
MAPK11	5600	broad.mit.edu	37	22	50705436	50705436	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:50705436C>T	ENST00000330651.6	-	7	637	c.537G>A	c.(535-537)atG>atA	p.M179I	MAPK11_ENST00000449719.2_Missense_Mutation_p.M71I	NM_002751.5	NP_002742.3	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	179	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			breast(1)|central_nervous_system(1)|lung(4)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATAGCCGGTCATCTCCTCGT	0.657000													12	44					0	0	0.387290	0	0
DNAH11	8701	broad.mit.edu	37	7	21631013	21631013	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:21631013C>T	ENST00000328843.6	+	14	2516	c.2485C>T	c.(2485-2487)Cgc>Tgc	p.R829C	DNAH11_ENST00000409508.3_Missense_Mutation_p.R829C			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	829	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R829C(2)		NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CAGAGTTGAGCGCACACAGAA	0.607000									Kartagener syndrome				14	33					0	0	0.520397	0	0
GMIP	51291	broad.mit.edu	37	19	19740837	19740837	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:19740837C>T	ENST00000203556.4	-	21	2985	c.2848G>A	c.(2848-2850)Gag>Aag	p.E950K	GMIP_ENST00000587238.1_Missense_Mutation_p.E924K|GMIP_ENST00000445806.2_Missense_Mutation_p.E921K	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	950					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GGCACAGCCTCGCTGTCCAAT	0.637000													2	1					0	0	0.115264	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250447	140250447	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:140250447G>T	ENST00000398640.2	+	1	1759	c.1759G>T	c.(1759-1761)Ggc>Tgc	p.G587C	PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGGTGCGGGCCACGTGGT	0.677000													22	95					1.13719e-10	1.31811e-10	0.729181	1	0
TMEM245	23731	broad.mit.edu	37	9	111849557	111849557	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:111849557C>T	ENST00000374586.3	-	6	1247	c.1216G>A	c.(1216-1218)Gtg>Atg	p.V406M		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	406						integral to membrane											CCCCACCACACATGGTAGCGT	0.413000													21	30					0	0	0.681144	0	0
ANKS3	124401	broad.mit.edu	37	16	4764077	4764077	+	Silent	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:4764077C>G	ENST00000304283.4	-	7	978	c.684G>C	c.(682-684)ctG>ctC	p.L228L	ANKS3_ENST00000585773.1_Silent_p.L155L|ANKS3_ENST00000446014.2_Silent_p.L99L|ANKS3_ENST00000450067.2_Silent_p.L22L	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	228										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						GGCTCTTGGGCAGAGAGGGCG	0.607000													18	36					0	0	0.557998	0	0
MALSU1	115416	broad.mit.edu	37	7	23347511	23347511	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:23347511G>T	ENST00000466681.1	+	3	613	c.460G>T	c.(460-462)Gac>Tac	p.D154Y		NM_138446.1	NP_612455.1	Q96EH3	CG030_HUMAN	mitochondrial assembly of ribosomal large subunit 1	154						mitochondrion											ATGTAAACGTGACCCTCATGT	0.428000													49	81					9.68594e-22	1.23496e-21	0.870114	1	0
TEF	7008	broad.mit.edu	37	22	41783535	41783535	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:41783535G>A	ENST00000266304.4	+	2	454	c.338G>A	c.(337-339)aGc>aAc	p.S113N	TEF_ENST00000406644.3_Missense_Mutation_p.S83N	NM_003216.3	NP_003207.1	Q10587	TEF_HUMAN	thyrotrophic embryonic factor	113					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						ATCCCCGCCAGCCCCACCCAC	0.587000													100	81					0	0	0.870114	0	0
RNF152	220441	broad.mit.edu	37	18	59483323	59483323	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:59483323C>G	ENST00000312828.3	-	2	1473	c.374G>C	c.(373-375)aGc>aCc	p.S125T		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	125					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				CTTCTGCTGGCTCCCGGGCAG	0.662000													19	7					0	0	0.654019	0	0
ZNF420	147923	broad.mit.edu	37	19	37619520	37619520	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:37619520G>A	ENST00000337995.3	+	5	1842	c.1627G>A	c.(1627-1629)Ggc>Agc	p.G543S	ZNF420_ENST00000304239.7_Intron|ZNF420_ENST00000586540.1_3'UTR|ZNF585A_ENST00000588723.1_Intron	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTTGCGCGTGGCTTACTACT	0.413000													28	54					0	0	0.706142	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105890144	105890144	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:105890144C>T	ENST00000393359.2	-	9	2095	c.1669G>A	c.(1669-1671)Gga>Aga	p.G557R	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.G557R			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	557					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						ACCTGAACTCCGACCTGAAAG	0.403000													5	21					0	0	0.278610	0	0
KCNH3	23416	broad.mit.edu	37	12	49944089	49944089	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:49944089G>T	ENST00000257981.6	+	10	2155	c.1895G>T	c.(1894-1896)gGt>gTt	p.G632V		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	632					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						GTGCTCAAGGGTGGCACCGTG	0.632000													18	78					6.12954e-19	7.55088e-19	0.681144	1	0
ZNF761	388561	broad.mit.edu	37	19	53958826	53958826	+	RNA	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:53958826G>A	ENST00000454407.1	+	0	1518							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.418000													6	304					0	0	0.307466	0	0
TTN	7273	broad.mit.edu	37	2	179613658	179613658	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:179613658A>G	ENST00000360870.5	-	46	13691	c.13469T>C	c.(13468-13470)aTt>aCt	p.I4490T	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	620	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTCATCAATCTTCTTTTG	0.313000													23	19					0	0	0.667858	0	0
DGKI	9162	broad.mit.edu	37	7	137271869	137271869	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:137271869G>T	ENST00000453654.2	-	13	1038	c.499C>A	c.(499-501)Ctg>Atg	p.L167M	DGKI_ENST00000288490.5_Missense_Mutation_p.L467M|DGKI_ENST00000446122.1_Missense_Mutation_p.L467M|DGKI_ENST00000424189.2_Missense_Mutation_p.L467M			O75912	DGKI_HUMAN	diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GTTCGAGCCAGGTCATTCCCA	0.552000													46	81					7.7325e-45	1.03235e-44	0.870114	1	0
KCNN4	3783	broad.mit.edu	37	19	44284956	44284956	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:44284956C>T	ENST00000262888.3	-	1	453	c.58G>A	c.(58-60)Gag>Aag	p.E20K		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	20					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TTCTCCTGCTCCAGCAAGCGC	0.662000													53	83					0	0	0.870114	0	0
RHOB	388	broad.mit.edu	37	2	20647449	20647449	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:20647449C>T	ENST00000272233.4	+	1	615	c.223C>T	c.(223-225)Ccg>Tcg	p.P75S		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTCCTACCCGGACACCGA	0.647000													52	54					0	0	0.870114	0	0
ZNF331	55422	broad.mit.edu	37	19	54080062	54080062	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:54080062G>T	ENST00000253144.9	+	7	1581	c.248G>T	c.(247-249)tGg>tTg	p.W83L	ZNF331_ENST00000449416.1_Missense_Mutation_p.W83L|ZNF331_ENST00000513265.1_Missense_Mutation_p.W83L|ZNF331_ENST00000511154.1_Missense_Mutation_p.W83L|ZNF331_ENST00000511593.2_Missense_Mutation_p.W83L|ZNF331_ENST00000513999.1_Missense_Mutation_p.W83L|ZNF331_ENST00000512387.1_Missense_Mutation_p.W83L|ZNF331_ENST00000411977.2_Missense_Mutation_p.W83L	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GGCCGTAACTGGATATGTGAA	0.398000			T	?	follicular thyroid adenoma								10	51					3.86212e-05	4.12067e-05	0.361761	1	0
SYPL1	6856	broad.mit.edu	37	7	105732326	105732326	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:105732326C>A	ENST00000455385.2	-	5	773	c.651G>T	c.(649-651)gaG>gaT	p.E217D	SYPL1_ENST00000011473.2_Missense_Mutation_p.E235D|SYPL1_ENST00000470347.1_3'UTR	NM_182715.2	NP_874384.1	Q16563	SYPL1_HUMAN	synaptophysin-like 1	235	MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	7						GTAGGCTGGTCTCCTTGTACA	0.383000													35	39					2.38262e-10	2.72453e-10	0.853193	1	0
TP63	8626	broad.mit.edu	37	3	189586386	189586386	+	Missense_Mutation	SNP	G	G	A	rs113993967		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:189586386G>A	ENST00000264731.3	+	8	1099	c.1010G>A	c.(1009-1011)cGa>cAa	p.R337Q	TP63_ENST00000320472.5_Missense_Mutation_p.R337Q|TP63_ENST00000418709.2_Missense_Mutation_p.R337Q|TP63_ENST00000392460.3_Missense_Mutation_p.R337Q|TP63_ENST00000392461.3_Missense_Mutation_p.R243Q|TP63_ENST00000354600.5_Missense_Mutation_p.R243Q|TP63_ENST00000437221.1_Missense_Mutation_p.R243Q|TP63_ENST00000382063.4_Missense_Mutation_p.R252Q|TP63_ENST00000392463.2_Missense_Mutation_p.R243Q|TP63_ENST00000449992.1_Missense_Mutation_p.R158Q|TP63_ENST00000456148.1_Missense_Mutation_p.R243Q|TP63_ENST00000440651.2_Missense_Mutation_p.R337Q	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	337			R -> Q (in ADULT syndrome; confers novel transcription activation capacity on isoform 6).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R337L(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTCCTGGGCCGACGCTGCTTT	0.483000										HNSCC(45;0.13)			6	17					0	0	0.248553	0	0
MDN1	23195	broad.mit.edu	37	6	90359913	90359913	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:90359913C>G	ENST00000369393.3	-	97	16151	c.16036G>C	c.(16036-16038)Gac>Cac	p.D5346H	MDN1_ENST00000428876.1_Missense_Mutation_p.D5346H			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	5346					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTCGATAGTCTCCTCTATTT	0.348000													12	1					0	0	0.479597	0	0
FLNC	2318	broad.mit.edu	37	7	128471003	128471003	+	Silent	SNP	C	C	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:128471003C>G	ENST00000325888.8	+	1	573	c.312C>G	c.(310-312)ctC>ctG	p.L104L	FLNC_ENST00000346177.6_Silent_p.L104L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	104	Actin-binding.|CH 1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCGTGGCCCTCGAGTTCCTCG	0.657000													32	37					0	0	0.834066	0	0
THOC2	57187	broad.mit.edu	37	X	122754808	122754808	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:122754808G>A	ENST00000245838.8	-	32	4256	c.4225C>T	c.(4225-4227)Cgc>Tgc	p.R1409C	THOC2_ENST00000355725.4_Missense_Mutation_p.R1409C|THOC2_ENST00000491737.1_Missense_Mutation_p.R1294C	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1409	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						ATTTTGCGGCGTTTTTGTTCT	0.398000													147	118					0	0	0.870114	0	0
DNAH1	25981	broad.mit.edu	37	3	52412779	52412779	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:52412779G>T	ENST00000420323.2	+	47	7621	c.7360G>T	c.(7360-7362)Gac>Tac	p.D2454Y		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2454					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCTCATGGCTGACCCGGCCAA	0.627000													68	62					6.15735e-50	8.30753e-50	0.870114	1	0
GPC5	2262	broad.mit.edu	37	13	92560246	92560246	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:92560246G>A	ENST00000377067.3	+	6	1708	c.1336G>A	c.(1336-1338)Gtc>Atc	p.V446I		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	446						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AAATCCTGAAGTCAAAGTCAA	0.378000													36	38					0	0	0.834066	0	0
CXorf22	170063	broad.mit.edu	37	X	35993361	35993361	+	Silent	SNP	G	G	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:35993361G>A	ENST00000297866.5	+	14	2418	c.2352G>A	c.(2350-2352)caG>caA	p.Q784Q		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	784										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTTTGCTCCAGTTAGATACTG	0.358000													90	83					0	0	0.870114	0	0
RBBP6	5930	broad.mit.edu	37	16	24582981	24582981	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:24582981A>G	ENST00000319715.4	+	18	5026	c.4594A>G	c.(4594-4596)Agt>Ggt	p.S1532G	RBBP6_ENST00000381039.3_Missense_Mutation_p.S692G|RBBP6_ENST00000348022.2_Missense_Mutation_p.S1498G	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1532	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TTCCAAAAAAAGTAATTCTAG	0.373000													3	14					0	0	0.150653	0	0
CHD3	1107	broad.mit.edu	37	17	7802505	7802505	+	Silent	SNP	C	C	T			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:7802505C>T	ENST00000380358.4	+	14	2506	c.2505C>T	c.(2503-2505)taC>taT	p.Y835Y	CHD3_ENST00000330494.7_Silent_p.Y776Y|CHD3_ENST00000358181.4_Silent_p.Y776Y	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	776	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TCTTCCTCTACTCACTCTACA	0.567000													58	18					0	0	0.870114	0	0
FAM43B	163933	broad.mit.edu	37	1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:20880268_20880270delGAG	ENST00000332947.4	+	1	1337_1339	c.802_804delGAG	c.(802-804)gagdel	p.E272del		NM_207334.2	NP_997217.1	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272										large_intestine(1)|lung(2)	3		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.744													7	11	---	---	---	---					
GRHL3	57822	broad.mit.edu	37	1	24663111	24663112	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:24663111_24663112insA	ENST00000361548.4	+	4	636_637	c.406_407insA	c.(406-408)gagfs	p.E136fs	GRHL3_ENST00000356046.2_Frame_Shift_Ins_p.E90fs|GRHL3_ENST00000530984.1_3'UTR|GRHL3_ENST00000236255.4_Frame_Shift_Ins_p.E141fs|GRHL3_ENST00000342072.4_Frame_Shift_Ins_p.E43fs|GRHL3_ENST00000350501.5_Frame_Shift_Ins_p.E136fs	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	136					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATGAGCTTGGAGGGGGCCTTG	0.579													27	85	---	---	---	---					
WDFY3	23001	broad.mit.edu	37	4	85611708	85611709	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:85611708_85611709delCA	ENST00000322366.6	-	60	9669_9670	c.9262_9263delTG	c.(9262-9264)tggfs	p.W3088fs	WDFY3_ENST00000295888.4_Frame_Shift_Del_p.W3105fs			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3105						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCCCATCTCCCACACACACACA	0.510													7	114	---	---	---	---					
KDM3B	51780	broad.mit.edu	37	5	137722024	137722028	+	Frame_Shift_Del	DEL	GGACT	GGACT	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:137722024_137722028delGGACT	ENST00000314358.5	+	7	1294_1298	c.1094_1098delGGACT	c.(1093-1098)aggactfs	p.RT365fs	KDM3B_ENST00000394866.1_Frame_Shift_Del_p.RT21fs	NM_016604.3	NP_057688	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	365					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						GAAAACGGCAGGACTCTGGTGGTGC	0.551													64	150	---	---	---	---					
RUFY1	80230	broad.mit.edu	37	5	178977642	178977642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:178977642delG	ENST00000377001.2	+	1	72	c.72delG	c.(70-72)ccgfs	p.P24fs	RUFY1_ENST00000319449.4_Frame_Shift_Del_p.P24fs			Q96T51	RUFY1_HUMAN	RUN and FYVE domain containing 1	24					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			agccggggccggggcCCGGGT	0.746										HNSCC(44;0.11)			2	4	---	---	---	---					
GDF6	392255	broad.mit.edu	37	8	97157110	97157111	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:97157110_97157111insA	ENST00000287020.5	-	2	1147_1148	c.1048_1049insT	c.(1048-1050)tccfs	p.S350fs		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	350					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					GCGTAGCCTGGACTTCTTGCCG	0.693													8	13	---	---	---	---					
NTRK2	4915	broad.mit.edu	37	9	87356831	87356837	+	Frame_Shift_Del	DEL	TAATTTA	TAATTTA	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:87356831_87356837delTAATTTA	ENST00000304053.6	+	10	1667_1673	c.1184_1190delTAATTTA	c.(1183-1191)gtaatttatfs	p.VIY395fs	NTRK2_ENST00000277120.3_Frame_Shift_Del_p.VIY395fs|NTRK2_ENST00000359847.3_Frame_Shift_Del_p.VIY395fs|NTRK2_ENST00000376213.1_Frame_Shift_Del_p.VIY395fs|NTRK2_ENST00000395866.2_Frame_Shift_Del_p.VIY239fs|NTRK2_ENST00000376208.1_Frame_Shift_Del_p.VIY395fs|NTRK2_ENST00000395882.1_Frame_Shift_Del_p.VIY395fs|NTRK2_ENST00000323115.4_Frame_Shift_Del_p.VIY395fs|NTRK2_ENST00000376214.1_Frame_Shift_Del_p.VIY395fs	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	395					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						TATCCTGATGTAATTTATGAAGGTAGC	0.309										TSP Lung(25;0.17)			7	19	---	---	---	---					
PVRL1	5818	broad.mit.edu	37	11	119549465	119549466	+	Frame_Shift_Ins	INS	-	-	GA			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:119549465_119549466insGA	ENST00000264025.3	-	2	619_620	c.89_90insTC	c.(88-90)tccfs	p.S30fs	PVRL1_ENST00000524510.1_5'UTR|PVRL1_ENST00000341398.2_Frame_Shift_Ins_p.S30fs|PVRL1_ENST00000340882.2_Frame_Shift_Ins_p.S30fs	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	30					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GGACCACCTGGGAGTGGACGCC	0.594													6	12	---	---	---	---					
DIS3	22894	broad.mit.edu	37	13	73337684	73337684	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:73337684delT	ENST00000377767.4	-	16	2132	c.2032delA	c.(2032-2034)attfs	p.I678fs	DIS3_ENST00000377780.4_Frame_Shift_Del_p.I648fs|DIS3_ENST00000545453.1_Frame_Shift_Del_p.I516fs	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	678					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCCTCATGAATTTTTTTTGCA	0.358										Multiple Myeloma(4;0.011)			7	76	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-519)gacaagfs	p.DK172fs	IL32_ENST00000534507.1_Frame_Shift_Ins_p.DK218fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.DK196fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.DK115fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.DK152fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.DK132fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.DK218fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.DK162fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.DK209fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.DK115fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.DK152fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.DK218fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.DK163fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.DK152fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.DK172fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.DK163fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.DK152fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.DK115fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													22	284	---	---	---	---					
CX3CL1	6376	broad.mit.edu	37	16	57416702	57416708	+	Frame_Shift_Del	DEL	ACCATGG	ACCATGG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:57416702_57416708delACCATGG	ENST00000565912.1	+	2	3544_3550	c.838_844delACCATGG	c.(838-846)accatggacfs	p.TMD280fs	CX3CL1_ENST00000563383.1_Frame_Shift_Del_p.TMD324fs|CX3CL1_ENST00000006053.6_Frame_Shift_Del_p.TMD318fs			P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	318	Mucin-like stalk.				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CATCCATGCCACCATGGACCCCCAGAG	0.662													17	72	---	---	---	---					
RP11-863P13.2	0	broad.mit.edu	37	16	88226895	88226897	+	RNA	DEL	TGG	TGG	-	rs62047004		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:88226895_88226897delTGG	ENST00000568587.1	-	0	91																											gtggtggagatggtggtggtggg	0.537													2	4	---	---	---	---					
RP11-161I6.2	0	broad.mit.edu	37	18	2089465	2089466	+	RNA	DEL	CA	CA	-	rs150342638	by1000genomes	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:2089465_2089466delCA	ENST00000579097.1	-	0	310																											ACTGCCCCCCCACCCACTCACC	0.525													4	2	---	---	---	---					
NKG7	4818	broad.mit.edu	37	19	51875242	51875244	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:51875242_51875244delAGG	ENST00000221978.5	-	3	568_570	c.389_391delCCT	c.(388-393)tcctgg>tgg	p.S130del	NKG7_ENST00000600427.1_Intron|NKG7_ENST00000595217.1_In_Frame_Del_p.P124del	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	130						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGAAGGACCAGGAGAAGAAGGT	0.611													26	74	---	---	---	---					
RP1-30E17.2	0	broad.mit.edu	37	X	127718074	127718075	+	RNA	DEL	AG	AG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:127718074_127718075delAG	ENST00000449485.1	-	0	158																											CTCTACATACagagagagagag	0.401													2	4	---	---	---	---					
DDX26B	203522	broad.mit.edu	37	X	134680317	134680317	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:134680317delT	ENST00000370752.4	+	4	686	c.352delT	c.(352-354)tttfs	p.F119fs	DDX26B_ENST00000481908.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	119	VWFA.									large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAAATCCATTTTTTTTAGA	0.274													34	41	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149984524	149984526	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:149984524_149984526delGTG	ENST00000370377.3	-	3	273_275	c.156_158delCAC	c.(154-159)accaca>aca	p.52_53TT>T	CD99L2_ENST00000437787.2_In_Frame_Del_p.52_53TT>T|CD99L2_ENST00000355149.3_Intron|CD99L2_ENST00000346693.4_5'UTR|CD99L2_ENST00000466436.1_Intron	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	52	Poly-Thr.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552													7	457	---	---	---	---