Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUC2	4583	broad.mit.edu	37	11	1092920	1092920	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:1092920C>A	ENST00000441003.2	+	30	4766	c.4739C>A	c.(4738-4740)aCc>aAc	p.T1580N	MUC2_ENST00000359061.5_Missense_Mutation_p.T1581N|MUC2_ENST00000361558.6_Intron	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1583	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ggcacacagaccccaacatcg	0.632000													5	44					0.217242	0.217242	1	1	0
MEGF8	1954	broad.mit.edu	37	19	42880156	42880156	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:42880156C>T	ENST00000334370.4	+	41	8201	c.7566C>T	c.(7564-7566)gtC>gtT	p.V2522V	MEGF8_ENST00000378073.4_Silent_p.V183V|MEGF8_ENST00000251268.6_Silent_p.V2589V	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2589						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TGCTGGTGGTCCGCGGCGTGC	0.692000													87	149					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25932610	25932610	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:25932610G>C	ENST00000398988.3	+	16	1865	c.1420G>C	c.(1420-1422)Gag>Cag	p.E474Q	KSR1_ENST00000319524.6_Missense_Mutation_p.E611Q|KSR1_ENST00000509603.2_Missense_Mutation_p.E589Q|KSR1_ENST00000268763.6_Missense_Mutation_p.E474Q	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	609					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CATCCCCTTCGAGCAGGTAGA	0.711000													3	10					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73843246	73843246	+	Silent	SNP	C	C	T	rs139916334		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:73843246C>T	ENST00000342056.2	+	11	1805	c.1407C>T	c.(1405-1407)acC>acT	p.T469T	KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000403813.2_Silent_p.T441T|KCNQ5_ENST00000370398.1_Silent_p.T450T|KCNQ5_ENST00000402622.2_Silent_p.T460T|KCNQ5_ENST00000355635.3_Silent_p.T451T|KCNQ5_ENST00000355194.4_Silent_p.T450T	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	450					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CCCCAAGCACCGACATCACAG	0.587000													47	56					0	0	1	0	0
PAPSS2	9060	broad.mit.edu	37	10	89504908	89504908	+	Silent	SNP	C	C	T	rs7918595		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:89504908C>T	ENST00000361175.4	+	11	1995	c.1626C>T	c.(1624-1626)ctC>ctT	p.L542L	PAPSS2_ENST00000456849.1_Silent_p.L547L|PAPSS2_ENST00000427144.2_Silent_p.L546L	NM_004670.3	NP_004661.2	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	542					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	20		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CCCCTGGCCTCACCTCTGTGG	0.512000													16	4					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102590767	102590767	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:102590767T>C	ENST00000330847.1	+	2	520	c.476T>C	c.(475-477)tTc>tCc	p.F159S	NR4A3_ENST00000338488.4_Missense_Mutation_p.F148S|NR4A3_ENST00000395097.2_Missense_Mutation_p.F148S			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	148					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding	p.Q162fs*89(1)	TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				ACGCCGGCCTTCCCCCCGCAG	0.721000			T	EWSR1	extraskeletal myxoid chondrosarcoma								4	91					0	0	1	0	0
DFNA5	1687	broad.mit.edu	37	7	24749946	24749946	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:24749946G>C	ENST00000545231.1	-	8	1417	c.267C>G	c.(265-267)gtC>gtG	p.V89V	DFNA5_ENST00000559637.1_5'UTR|DFNA5_ENST00000342947.3_Silent_p.V253V|DFNA5_ENST00000419307.1_Silent_p.V89V|DFNA5_ENST00000409775.3_Silent_p.V253V|DFNA5_ENST00000409970.1_Silent_p.V89V			O60443	DFNA5_HUMAN	deafness, autosomal dominant 5	253					sensory perception of sound					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)|stomach(1)	19						GGTCCAGGTAGACAGAGTCAA	0.473000													14	61					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202400897	202400897	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:202400897C>T	ENST00000439140.1	-	13	1397	c.1353G>A	c.(1351-1353)caG>caA	p.Q451Q	ALS2CR11_ENST00000286195.3_Silent_p.Q451Q|ALS2CR11_ENST00000450242.1_Silent_p.Q451Q|ALS2CR11_ENST00000439802.1_Intron	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	451										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						TTATTGTTTCCTGGTTAGAAA	0.373000													8	55					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57714456	57714456	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:57714456C>A	ENST00000333493.4	+	8	969	c.808C>A	c.(808-810)Cgc>Agc	p.R270S	GPR97_ENST00000327655.6_Missense_Mutation_p.R60S|GPR97_ENST00000450388.3_Missense_Mutation_p.R150S	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	270					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R270C(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TATCCTCACACGCATCTCCCA	0.577000													31	86					1.96642e-18	2.08932e-18	1	1	0
NUP155	9631	broad.mit.edu	37	5	37292081	37292081	+	Missense_Mutation	SNP	G	G	C	rs140076285	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:37292081G>C	ENST00000231498.3	-	35	4300	c.4097C>G	c.(4096-4098)tCt>tGt	p.S1366C	NUP155_ENST00000502533.1_5'UTR|NUP155_ENST00000513532.1_Missense_Mutation_p.S1302C|NUP155_ENST00000381843.2_Missense_Mutation_p.S1307C	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1366					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGAGCTCATAGACTGGAGCTC	0.363000													18	47					0	0	1	0	0
GOLGA5	9950	broad.mit.edu	37	14	93299516	93299516	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:93299516G>A	ENST00000163416.2	+	10	2025	c.1769G>A	c.(1768-1770)cGa>cAa	p.R590Q	GOLGA5_ENST00000355976.2_Missense_Mutation_p.R590Q	NM_005113.2	NP_005104	Q8TBA6	GOGA5_HUMAN	golgin A5	590					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		TTAGAAAATCGACTCCATCAG	0.403000			T	RET	papillary thyroid								12	38					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100483362	100483362	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:100483362C>G	ENST00000388793.4	+	11	1575	c.1355C>G	c.(1354-1356)tCa>tGa	p.S452*	SRRT_ENST00000347433.4_Nonsense_Mutation_p.S453*|SRRT_ENST00000457580.2_Nonsense_Mutation_p.S453*|SRRT_ENST00000432932.1_Nonsense_Mutation_p.S452*	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	453					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GTGGCGCTCTCAGAGCCCCAG	0.537000													5	21					0	0	1	0	0
PFKFB3	5209	broad.mit.edu	37	10	6261552	6261552	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:6261552G>A	ENST00000536985.1	+	7	589	c.509G>A	c.(508-510)cGg>cAg	p.R170Q	PFKFB3_ENST00000317350.4_Silent_p.P173P|PFKFB3_ENST00000379775.4_Silent_p.P173P|PFKFB3_ENST00000379785.1_Silent_p.P173P|PFKFB3_ENST00000540253.1_Silent_p.P187P|PFKFB3_ENST00000360521.2_Silent_p.P173P|PFKFB3_ENST00000379782.3_Silent_p.P173P|PFKFB3_ENST00000379789.4_Silent_p.P153P			Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding	p.P173P(1)		central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						TCTCCAGCCCGGATTACAAAG	0.507000													5	110					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43991401	43991401	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:43991401T>C	ENST00000282406.4	+	29	4303	c.4193T>C	c.(4192-4194)aTg>aCg	p.M1398T		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1398	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAGAGTCTAATGACCTTTGGA	0.328000													16	19					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96054015	96054015	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:96054015A>G	ENST00000358812.4	+	5	1257	c.1123A>G	c.(1123-1125)Aac>Gac	p.N375D		NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	375	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		AAACACTCGGAACCGAATCAA	0.413000													47	39					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650738	90650738	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650738C>T	ENST00000282146.4	+	2	1059	c.618C>T	c.(616-618)atC>atT	p.I206I		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	206						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CAGCCTCCATCCTCATCTCTT	0.562000													34	162					0	0	1	0	0
AFMID	125061	broad.mit.edu	37	17	76201688	76201688	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:76201688G>T	ENST00000409257.5	+	9	703	c.649G>T	c.(649-651)Gac>Tac	p.D217Y	AFMID_ENST00000589664.1_Intron|AFMID_ENST00000591952.1_Intron|AFMID_ENST00000588800.1_Intron|AFMID_ENST00000327898.5_Missense_Mutation_p.D217Y	NM_001010982.4|NM_001145526.2	NP_001010982.2|NP_001138998.1	Q63HM1	AFMID_HUMAN	arylformamidase	217						cytosol|nucleus	arylformamidase activity			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)	19			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CCCCAGGGAGGACGCTCAGAG	0.672000													19	57					4.63292e-17	4.89191e-17	1	1	0
ADCY10	55811	broad.mit.edu	37	1	167792259	167792259	+	Silent	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:167792259G>T	ENST00000367848.1	-	29	4376	c.3879C>A	c.(3877-3879)atC>atA	p.I1293I	ADCY10_ENST00000545172.1_Silent_p.I1232I|ADCY10_ENST00000367851.4_Silent_p.I1385I			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1385					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AATAAAGCAGGATGTCCAAGC	0.502000													16	39					1.33834e-09	1.3873e-09	1	1	0
RYR3	6263	broad.mit.edu	37	15	33936718	33936718	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:33936718G>C	ENST00000389232.4	+	28	3833	c.3763G>C	c.(3763-3765)Gag>Cag	p.E1255Q	RYR3_ENST00000415757.3_Missense_Mutation_p.E1255Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1255	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCACACATAGAGGTAATGTT	0.512000													6	13					0	0	1	0	0
C16orf82	162083	broad.mit.edu	37	16	27078256	27078256	+	RNA	SNP	A	A	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:27078256A>T	ENST00000505035.1	+	0	229				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			TTATATACGGAGTCACCTCTC	0.577000													18	22					0	0	1	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71187068	71187068	+	Splice_Site	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:71187068G>A	ENST00000234396.4	+	6	518		c.e6-1		ATP6V1B1_ENST00000412314.1_Splice_Site|AC007040.11_ENST00000606025.1_Intron	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1						ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						CCCTCTCCCAGGCCAGCCCAT	0.597000													30	103					0	0	1	0	0
PI15	51050	broad.mit.edu	37	8	75737599	75737599	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:75737599G>A	ENST00000260113.2	+	2	294	c.115G>A	c.(115-117)Gat>Aat	p.D39N	PI15_ENST00000523773.1_Missense_Mutation_p.D39N|RP11-758M4.4_ENST00000523860.1_RNA|RP11-758M4.4_ENST00000518128.1_RNA	NM_015886.3	NP_056970.1	O43692	PI15_HUMAN	peptidase inhibitor 15	39						extracellular region	peptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|skin(1)	30	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TAATTTCACTGATATTGAAGC	0.488000													50	50					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71494257	71494257	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:71494257C>G	ENST00000296755.7	+	5	5373	c.5075C>G	c.(5074-5076)tCt>tGt	p.S1692C		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1692						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TACAGTCCTTCTGACATGCAG	0.488000													33	16					0	0	1	0	0
IL10RA	3587	broad.mit.edu	37	11	117869673	117869673	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:117869673G>A	ENST00000227752.3	+	7	1174	c.1054G>A	c.(1054-1056)Gag>Aag	p.E352K	IL10RA_ENST00000545409.1_Missense_Mutation_p.E203K|IL10RA_ENST00000541785.1_Missense_Mutation_p.E332K|IL10RA_ENST00000533700.1_3'UTR	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	352						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GGGAAACAGGGAGCCCCCTGT	0.647000													19	29					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133732691	133732691	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:133732691C>T	ENST00000248211.6	+	5	1081	c.859C>T	c.(859-861)Cat>Tat	p.H287Y	ZNF268_ENST00000416488.1_Intron|CTD-2140B24.4_ENST00000540096.2_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.H287Y|ZNF10_ENST00000402932.2_Missense_Mutation_p.H153Y	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TCAGCTTATTCATACTGGAGA	0.418000													9	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179610636	179610636	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:179610636C>G	ENST00000360870.5	-	46	16713	c.16491G>C	c.(16489-16491)aaG>aaC	p.K5497N	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8982	Ig-like 35.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAGTTGCTCTTTAAGACCA	0.408000													15	44					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50302947	50302947	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:50302947G>A	ENST00000354293.5	+	10	1362	c.1196G>A	c.(1195-1197)cGg>cAg	p.R399Q	AP2A1_ENST00000359032.5_Missense_Mutation_p.R399Q	NM_130787.2	NP_570603.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	399					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ATGTGTGACCGGAGCAATGCC	0.647000													83	136					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6954874	6954874	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:6954874C>G	ENST00000229264.3	+	10	1229	c.824C>G	c.(823-825)tCc>tGc	p.S275C	GNB3_ENST00000435982.2_Missense_Mutation_p.S274C|CDCA3_ENST00000422785.3_3'UTR|CDCA3_ENST00000604599.1_5'UTR	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	275					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						GGCATCACGTCCGTGGCCTTC	0.597000													149	237					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89914805	89914805	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:89914805G>A	ENST00000534061.1	+	17	2106	c.1876G>A	c.(1876-1878)Gtg>Atg	p.V626M	NAALAD2_ENST00000375944.3_Intron|NAALAD2_ENST00000321955.4_Missense_Mutation_p.V593M	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	626					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ATTTTCTGCTGTGAAAAACTT	0.318000													3	10					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713944	142713944	+	RNA	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:142713944C>T	ENST00000610091.1	-	0	1714																											TGATTACCTCCGAAGTTAAAG	0.308000													3	4					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134223	22134223	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:22134223G>A	ENST00000408935.1	+	1	927	c.927G>A	c.(925-927)acG>acA	p.T309T		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T309T(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TTTTTTTCACGAAATCATATA	0.393000													4	11					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	196792639	196792639	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:196792639C>G	ENST00000346964.2	-	22	2428	c.2239G>C	c.(2239-2241)Gac>Cac	p.D747H	DLG1_ENST00000357674.4_Missense_Mutation_p.D714H|DLG1_ENST00000448528.2_Missense_Mutation_p.D725H|DLG1_ENST00000314062.3_Missense_Mutation_p.D674H|DLG1_ENST00000443183.1_Missense_Mutation_p.D621H|DLG1_ENST00000422288.1_Missense_Mutation_p.D674H|DLG1_ENST00000392382.2_Missense_Mutation_p.D692H|DLG1_ENST00000450955.1_Missense_Mutation_p.D714H|DLG1_ENST00000419354.1_Missense_Mutation_p.D725H|DLG1_ENST00000452595.1_Missense_Mutation_p.D609H	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	725	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TTTATCCTGTCTTTCATAGGT	0.299000													12	42					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5086617	5086617	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:5086617T>C	ENST00000399604.4	-	1	1075	c.935A>G	c.(934-936)gAa>gGa	p.E312G	ZNF594_ENST00000575779.1_Missense_Mutation_p.E312G			Q96JF6	ZN594_HUMAN	zinc finger protein 594	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TCTCTGGTGTTCAGTAAGGTG	0.453000													21	25					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3644231	3644231	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:3644231C>T	ENST00000378295.4	+	8	1037	c.882C>T	c.(880-882)atC>atT	p.I294I	TP73_ENST00000604074.1_Silent_p.I294I|TP73_ENST00000354437.4_Silent_p.I294I|TP73_ENST00000378290.4_Silent_p.I223I|TP73_ENST00000378285.1_Silent_p.I245I|TP73_ENST00000603362.1_Silent_p.I294I|TP73_ENST00000604479.1_Silent_p.I294I|TP73_ENST00000378288.4_Silent_p.I245I|TP73_ENST00000357733.3_Silent_p.I294I|TP73_ENST00000346387.4_Silent_p.I294I|TP73_ENST00000378280.1_Silent_p.I245I	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	294	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		AGGGCCGCATCTGCGCCTGTC	0.672000													7	14					0	0	1	0	0
SLC25A29	123096	broad.mit.edu	37	14	100758860	100758860	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:100758860G>A	ENST00000554912.1	-	2	3761	c.474C>T	c.(472-474)ggC>ggT	p.G158G	SLC25A29_ENST00000539621.1_Silent_p.G158G|SLC25A29_ENST00000392908.3_3'UTR|SLC25A29_ENST00000359232.3_Silent_p.G224G|RP11-638I2.6_ENST00000556458.1_lincRNA|SLC25A29_ENST00000556505.1_Silent_p.G158G|SLC25A29_ENST00000555927.1_Silent_p.G158G			Q8N8R3	MCATL_HUMAN	solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29	224						integral to membrane|mitochondrial inner membrane	binding			NS(1)|endometrium(1)|ovary(1)	3		Melanoma(154;0.152)			L-Carnitine(DB00583)	AGCGCGGGGCGCCCCGCAGTC	0.706000													7	19					0	0	1	0	0
API5	8539	broad.mit.edu	37	11	43333683	43333683	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:43333683G>A	ENST00000378852.3	+	1	131	c.6G>A	c.(4-6)ccG>ccA	p.P2P	API5_ENST00000420461.2_Silent_p.P2P|API5_ENST00000531273.1_Silent_p.P2P|API5_ENST00000455725.2_5'UTR|API5_ENST00000534600.1_Silent_p.P2P|API5_ENST00000534695.1_Silent_p.P2P	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	2		Not acetylated.			anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						TCACCATGCCGACAGTAGAGG	0.647000											OREG0020900	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	35					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	418436	418436	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:418436G>A	ENST00000332826.6	-	23	2368	c.2284C>T	c.(2284-2286)Cgg>Tgg	p.R762W		NM_001012302.2	NP_001012302	A1A5B4	ANO9_HUMAN	anoctamin 9	762						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						ATTGGGGGCCGAGAGCCTGCC	0.627000													14	28					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650948	90650948	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650948C>G	ENST00000282146.4	+	2	1269	c.828C>G	c.(826-828)ttC>ttG	p.F276L		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	276						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				ACTCCTTGTTCAATGTCATCT	0.522000													23	78					0	0	1	0	0
RNF7	9616	broad.mit.edu	37	3	141462354	141462354	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:141462354C>T	ENST00000273480.3	+	2	317	c.179C>T	c.(178-180)gCc>gTc	p.A60V	RNF7_ENST00000393000.3_Missense_Mutation_p.P58S|RNF7_ENST00000480908.1_Intron	NM_014245.4|NM_183237.2	NP_055060.1|NP_899060.1	Q9UBF6	RBX2_HUMAN	ring finger protein 7	60					anti-apoptosis|induction of apoptosis by oxidative stress|protein neddylation|response to redox state	cytoplasm|nucleus	copper ion binding|NEDD8 ligase activity|protein binding|zinc ion binding			kidney(1)|lung(3)|upper_aerodigestive_tract(1)	5						CTTTTAGATGCCTGTCTTAGA	0.373000													16	35					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90695108	90695108	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:90695108C>T	ENST00000458208.1	-	9	1480	c.1006G>A	c.(1006-1008)Gag>Aag	p.E336K	ACTA2-AS1_ENST00000437930.4_RNA|ACTA2_ENST00000224784.6_Missense_Mutation_p.E336K|STAMBPL1_ENST00000371927.3_Intron	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	336					response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TATTTGCGCTCCGGAGGGGCA	0.507000											OREG0020356	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	16					0	0	1	0	0
GPR107	57720	broad.mit.edu	37	9	132889830	132889830	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:132889830G>A	ENST00000372406.1	+	18	2076	c.1569G>A	c.(1567-1569)tgG>tgA	p.W523*	GPR107_ENST00000347136.6_Nonsense_Mutation_p.W475*|GPR107_ENST00000372410.3_Nonsense_Mutation_p.W494*	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	523						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				CATTCCAGTGGAAGTGGCTCT	0.418000													25	12					0	0	1	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705613	41705613	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:41705613C>A	ENST00000379485.1	-	1	1269	c.1035G>T	c.(1033-1035)atG>atT	p.M345I	KBTBD6_ENST00000499385.2_Missense_Mutation_p.M279I	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	345							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AGAAGATCACCATCTCCTTGG	0.527000													5	63					0.000673444	0.000679439	1	1	0
EP300	2033	broad.mit.edu	37	22	41573719	41573719	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573719C>G	ENST00000263253.7	+	31	7223	c.6004C>G	c.(6004-6006)Cag>Gag	p.Q2002E	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2002					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AGGATTGCCTCAGCCCCAGCA	0.602000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				37	17					0	0	1	0	0
ZNF32	7580	broad.mit.edu	37	10	44140096	44140096	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:44140096C>G	ENST00000395797.1	-	3	412	c.224G>C	c.(223-225)aGg>aCg	p.R75T	ZNF32-AS3_ENST00000458063.1_RNA|ZNF32_ENST00000485351.1_Intron|ZNF32_ENST00000374433.2_Missense_Mutation_p.R75T|ZNF32-AS1_ENST00000453284.1_RNA	NM_001005368.1	NP_001005368.1	P17041	ZNF32_HUMAN	zinc finger protein 32	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	14		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		CTCATAGACCCTTTGTCTCAC	0.448000													37	23					0	0	1	0	0
C7orf26	79034	broad.mit.edu	37	7	6629998	6629998	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:6629998C>T	ENST00000344417.5	+	1	351	c.84C>T	c.(82-84)ttC>ttT	p.F28F	C7orf26_ENST00000359073.5_Silent_p.F28F	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	28										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		ACATCTACTTCAGCAGCCAGC	0.692000													15	25					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7278084	7278084	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:7278084G>C	ENST00000436587.2	+	3	642	c.419G>C	c.(418-420)aGa>aCa	p.R140T	C1GALT1_ENST00000402468.3_Missense_Mutation_p.R140T|C1GALT1_ENST00000223122.3_Missense_Mutation_p.R140T	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	140					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AAAGAAGGCAGAGATCAACTA	0.373000													8	26					0	0	1	0	0
EIF3L	51386	broad.mit.edu	37	22	38266268	38266268	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:38266268G>A	ENST00000412331.2	+	8	1247	c.665G>A	c.(664-666)tGg>tAg	p.W222*	EIF3L_ENST00000476955.1_3'UTR|EIF3L_ENST00000406934.1_Nonsense_Mutation_p.W124*|EIF3L_ENST00000381683.6_Nonsense_Mutation_p.W174*	NM_016091.3	NP_057175.1	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3, subunit L	222						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			kidney(2)|large_intestine(3)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CCCAAAATCTGGAATGTTCAT	0.458000													16	25					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79284133	79284133	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284133C>T	ENST00000419573.3	-	22	3353	c.3079G>A	c.(3079-3081)Gaa>Aaa	p.E1027K	RASGRF1_ENST00000394745.3_Missense_Mutation_p.E243K|RASGRF1_ENST00000558480.2_Missense_Mutation_p.E1011K|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1029					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTCACGCCTTCAGCCTGGTTT	0.547000													6	27					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000236957.5_Silent_p.P45P|EEF1B2_ENST00000392221.1_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													5	92					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3998602	3998602	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:3998602C>T	ENST00000404826.2	+	8	1329	c.1190C>T	c.(1189-1191)tCa>tTa	p.S397L	SDK1_ENST00000389531.3_Missense_Mutation_p.S397L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	397	Ig-like C2-type 4.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGTCGGATTTCAGCTGAAGTA	0.468000													17	71					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5214591	5214591	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:5214591C>T	ENST00000372412.4	-	29	4711	c.4478G>A	c.(4477-4479)cGg>cAg	p.R1493Q	PTPRS_ENST00000262963.6_Missense_Mutation_p.R1472Q|PTPRS_ENST00000587303.1_Missense_Mutation_p.R1492Q|PTPRS_ENST00000588012.1_Missense_Mutation_p.R1454Q|PTPRS_ENST00000348075.2_Missense_Mutation_p.R1454Q|PTPRS_ENST00000353284.2_Missense_Mutation_p.R1045Q|PTPRS_ENST00000357368.4_Missense_Mutation_p.R1492Q|PTPRS_ENST00000592099.1_Missense_Mutation_p.R1045Q|PTPRS_ENST00000588552.1_5'UTR			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1492	Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CTCCTCCAGCCGCGTCATCAT	0.632000													19	55					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17250767	17250767	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:17250767C>T	ENST00000285681.2	+	25	3606	c.3237C>T	c.(3235-3237)ctC>ctT	p.L1079L	USP25_ENST00000400183.2_Silent_p.L1117L|USP25_ENST00000351097.5_Silent_p.L442L|USP25_ENST00000285679.6_Silent_p.L1047L	NM_001283042.1	NP_001269971.1	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	1047					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TGTTGTCCCTCAGTCGAACTC	0.433000													32	35					0	0	1	0	0
C7orf57	136288	broad.mit.edu	37	7	48080989	48080989	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:48080989G>A	ENST00000348904.3	+	3	326	c.114G>A	c.(112-114)gcG>gcA	p.A38A	C7orf57_ENST00000435376.1_5'UTR|C7orf57_ENST00000430738.1_Silent_p.A83A|C7orf57_ENST00000539619.1_Silent_p.A38A|C7orf57_ENST00000420324.1_Silent_p.A83A	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	38										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						CCCCACCAGCGTCCCAGATCC	0.537000													36	49					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33928729	33928729	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:33928729C>T	ENST00000389232.4	+	27	3604	c.3534C>T	c.(3532-3534)ttC>ttT	p.F1178F	RYR3_ENST00000415757.3_Silent_p.F1178F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1178	4 X approximate repeats.|B30.2/SPRY 2.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.F1178F(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AACTTGCCTTCGCTGACTACG	0.493000													11	54					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70071201	70071201	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:70071201G>C	ENST00000446444.1	-	4	1095	c.1087C>G	c.(1087-1089)Cta>Gta	p.L363V	RP11-704M14.1_ENST00000505646.1_RNA|RP11-704M14.1_ENST00000504301.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	363					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GTGTTACCTAGAAGGTCATTC	0.378000													24	65					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39438670	39438670	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:39438670G>A	ENST00000280481.7	+	16	8126	c.7910G>A	c.(7909-7911)tGg>tAg	p.W2637*		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2637					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCTGTTTATGGGAGTTCGTT	0.458000													20	27					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862968	10862968	+	RNA	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:10862968C>A	ENST00000559480.1	+	0	264																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						CCAGAGTCACCATAACCAGGG	0.527000													66	410					1.54081e-58	1.66839e-58	1	1	0
METRNL	284207	broad.mit.edu	37	17	81043019	81043019	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:81043019G>A	ENST00000571814.1	+	1	1071	c.130G>A	c.(130-132)Gaa>Aaa	p.E44K	METRNL_ENST00000570778.1_Missense_Mutation_p.E44K|METRNL_ENST00000320095.7_Missense_Mutation_p.E126K			Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation regulator-like	126						extracellular region				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AAAAACTGGAGAACTGAGACT	0.637000													4	66					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16199610	16199610	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:16199610G>A	ENST00000375759.3	+	2	587	c.383G>A	c.(382-384)cGt>cAt	p.R128H		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	128	Arg-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGAGAAGGACGTTATGAGCGG	0.488000													19	38					0	0	1	0	0
NSUN3	63899	broad.mit.edu	37	3	93802971	93802971	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:93802971C>G	ENST00000314622.4	+	3	354	c.143C>G	c.(142-144)tCa>tGa	p.S48*		NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	48							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						ACATCTCCATCATGCTGGCAA	0.338000													23	24					0	0	1	0	0
SENP5	205564	broad.mit.edu	37	3	196613169	196613169	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:196613169C>T	ENST00000323460.5	+	2	1366	c.1117C>T	c.(1117-1119)Cat>Tat	p.H373Y	SENP5_ENST00000445299.2_Missense_Mutation_p.H373Y|SENP5_ENST00000419026.1_Intron	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	373					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity	p.H373Y(1)		NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGAGCTGATTCATGACATCCC	0.443000													6	38					0	0	1	0	0
ODF4	146852	broad.mit.edu	37	17	8248778	8248778	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:8248778T>C	ENST00000328248.2	+	2	760	c.572T>C	c.(571-573)aTc>aCc	p.I191T	ODF4_ENST00000584943.1_Missense_Mutation_p.I76T	NM_153007.4	NP_694552.2	Q2M2E3	ODFP4_HUMAN	outer dense fiber of sperm tails 4	191					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|stomach(1)	8						CTGGTGCTTATCCTATACTTC	0.532000													75	30					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34151822	34151822	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:34151822T>G	ENST00000389232.4	+	100	14259	c.14189T>G	c.(14188-14190)aTt>aGt	p.I4730S	RP11-3D4.2_ENST00000560268.1_RNA|RYR3_ENST00000415757.3_Missense_Mutation_p.I4725S	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4730					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGAGGTGGCATTGGTGATGAA	0.423000													9	29					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	44878109	44878109	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:44878109C>G	ENST00000355387.2	+	2	790	c.340C>G	c.(340-342)Cat>Gat	p.H114D	RNF220_ENST00000361799.2_Missense_Mutation_p.H114D|RNF220_ENST00000372247.2_Missense_Mutation_p.H114D			Q5VTB9	RN220_HUMAN	ring finger protein 220	114					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						TATGCTGAATCATAGTGGTGT	0.537000													108	78					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145894746	145894746	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:145894746C>T	ENST00000311104.2	-	1	1007	c.931G>A	c.(931-933)Gaa>Aaa	p.E311K		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	311						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGAACTCTTCCGACATCACA	0.478000													7	8					0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57133966	57133966	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:57133966G>A	ENST00000328070.6	+	3	1545	c.1311G>A	c.(1309-1311)ccG>ccA	p.P437P		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	437						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GCGAGAAGCCGTACAGGTGCG	0.647000													4	102					0	0	1	0	0
ZNF645	158506	broad.mit.edu	37	X	22291896	22291896	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:22291896G>A	ENST00000323684.1	+	1	832	c.788G>A	c.(787-789)tGt>tAt	p.C263Y		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	263	Pro-rich.					intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						TATCCTGAGTGTCAAAGTCAA	0.413000													55	70					0	0	1	0	0
MRS2	57380	broad.mit.edu	37	6	24416692	24416692	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:24416692G>C	ENST00000378386.3	+	7	880	c.787G>C	c.(787-789)Gag>Cag	p.E263Q	MRS2_ENST00000535061.1_Missense_Mutation_p.E213Q|MRS2_ENST00000378353.1_Missense_Mutation_p.E263Q|MRS2_ENST00000543597.1_5'UTR|MRS2_ENST00000483634.1_3'UTR|MRS2_ENST00000274747.7_3'UTR|MRS2_ENST00000443868.2_Missense_Mutation_p.E266Q	NM_020662.2	NP_065713.1	Q9HD23	MRS2_HUMAN	MRS2 magnesium transporter	263					ion transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12						GGATGAGGAAGAGTTGCTAGA	0.294000													41	7					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026793	79026793	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:79026793G>A	ENST00000446378.2	+	2	2236	c.2205G>A	c.(2203-2205)gaG>gaA	p.E735E		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	735						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CATCAGAAGAGAAGGAAGACA	0.463000													13	49					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9190395	9190395	+	Silent	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:9190395G>T	ENST00000382496.5	-	11	1922	c.1257C>A	c.(1255-1257)atC>atA	p.I419I		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	419	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CCAAATAGATGATGTGGACGA	0.498000													8	34					0.000442599	0.000447868	1	1	0
SAMD15	161394	broad.mit.edu	37	14	77843846	77843846	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:77843846C>T	ENST00000216471.4	+	1	371	c.85C>T	c.(85-87)Cat>Tat	p.H29Y	SAMD15_ENST00000533095.2_Intron	NM_001010860.1	NP_001010860.1	Q9P1V8	SAM15_HUMAN	sterile alpha motif domain containing 15	29										breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCCTGGACTTCATAAATTGTA	0.517000													15	21					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657918	143657918	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:143657918G>A	ENST00000392899.1	+	1	892	c.855G>A	c.(853-855)ctG>ctA	p.L285L		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CACCAATGCTGAACCCCATGA	0.453000													26	46					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41572932	41572932	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41572932C>G	ENST00000263253.7	+	31	6436	c.5217C>G	c.(5215-5217)atC>atG	p.I1739M	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1739	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AGCGCTGCATCCAGTCTCTGG	0.562000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				37	16					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090509	238090509	+	RNA	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:238090509T>C	ENST00000450451.1	+	0	2015					NR_027247.2																						TTTGAGACCTTCAACTCCCCG	0.607000													21	73					0	0	1	0	0
CTSB	1508	broad.mit.edu	37	8	11708405	11708405	+	Missense_Mutation	SNP	G	G	C	rs144771892		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:11708405G>C	ENST00000353047.6	-	4	550	c.297C>G	c.(295-297)atC>atG	p.I99M	CTSB_ENST00000531089.1_Missense_Mutation_p.I99M|CTSB_ENST00000345125.3_Missense_Mutation_p.I99M|CTSB_ENST00000453527.2_Missense_Mutation_p.I99M|CTSB_ENST00000415599.2_Missense_Mutation_p.I99M|CTSB_ENST00000525076.1_5'UTR|CTSB_ENST00000530640.2_Missense_Mutation_p.I99M|CTSB_ENST00000434271.1_Missense_Mutation_p.I99M|CTSB_ENST00000534510.1_Missense_Mutation_p.I99M|CTSB_ENST00000533455.1_Missense_Mutation_p.I99M	NM_001908.3	NP_001899.1	P07858	CATB_HUMAN	cathepsin B	99					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(1)	16	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CCTGGTCTCTGATCTCTTTGA	0.572000													10	14					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119158371	119158371	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:119158371A>G	ENST00000296499.5	+	10	2517	c.2114A>G	c.(2113-2115)tAc>tGc	p.Y705C		NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	705	Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						TACTCCTGGTACCAGGTAAGG	0.443000													8	35					0	0	1	0	0
TSPAN4	7106	broad.mit.edu	37	11	862710	862710	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:862710C>T	ENST00000397404.1	+	4	483	c.224C>T	c.(223-225)gCc>gTc	p.A75V	TSPAN4_ENST00000397397.2_Missense_Mutation_p.A75V|TSPAN4_ENST00000397396.1_Missense_Mutation_p.A11V|TSPAN4_ENST00000409531.1_Missense_Mutation_p.A94V|TSPAN4_ENST00000397408.1_Missense_Mutation_p.A75V|TSPAN4_ENST00000397411.2_Missense_Mutation_p.A75V|TSPAN4_ENST00000409543.2_Missense_Mutation_p.A75V|TSPAN4_ENST00000346501.4_Missense_Mutation_p.A75V|TSPAN4_ENST00000525201.1_Missense_Mutation_p.A11V|TSPAN4_ENST00000397406.1_Missense_Mutation_p.A75V	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	75					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCCTGGGTGCCATCAAGGAG	0.667000													8	22					0	0	1	0	0
HSF1	3297	broad.mit.edu	37	8	145535421	145535421	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:145535421C>T	ENST00000528838.1	+	8	919	c.759C>T	c.(757-759)taC>taT	p.Y253Y	HSF1_ENST00000400780.4_Silent_p.Y188Y	NM_005526.2	NP_005517.1	Q00613	HSF1_HUMAN	heat shock transcription factor 1	253	Regulatory domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)|urinary_tract(2)	11	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCAGCCTCTACGCCCCTGATG	0.672000													26	83					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794089	140794089	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140794089C>T	ENST00000398610.2	+	1	1347	c.1347C>T	c.(1345-1347)atC>atT	p.I449I	PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB4_ENST00000519479.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGATATCAATGACAACC	0.498000													27	113					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89522638	89522638	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:89522638C>G	ENST00000370473.4	-	7	1273	c.1054G>C	c.(1054-1056)Gag>Cag	p.E352Q		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	352					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCCAGCAGCTCCTGGAGGGTT	0.517000													18	48					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206882469	206882469	+	Missense_Mutation	SNP	A	A	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:206882469A>C	ENST00000403263.1	-	8	1881	c.1477T>G	c.(1477-1479)Tgc>Ggc	p.C493G		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	493					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						GGCACAGAGCACTGCTGTCCA	0.413000													9	11					0	0	1	0	0
MIR4485	100616263	broad.mit.edu	37	MT	2978	2978	+	RNA	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrM:2978T>C	ENST00000387347.2	+	0	1308					NR_039705.1																						TCAACAATAGGGTTTACGACC	0.433000													9	151					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20999096	20999096	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:20999096C>T	ENST00000261383.3	-	46	6800	c.6801G>A	c.(6799-6801)tcG>tcA	p.S2267S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2267	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.S2267S(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AATGTGACTTCGAGGGAGTTG	0.493000													29	12					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4711438	4711438	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:4711438G>A	ENST00000302640.8	+	18	2292	c.1942G>A	c.(1942-1944)Gac>Aac	p.D648N	ITPR1_ENST00000456211.2_Missense_Mutation_p.D648N|ITPR1_ENST00000357086.4_Missense_Mutation_p.D663N|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000443694.2_Missense_Mutation_p.D648N|ITPR1_ENST00000354582.6_Missense_Mutation_p.D663N|ITPR1_ENST00000423119.2_Missense_Mutation_p.D663N	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	663					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding	p.D648Y(2)|p.D663Y(1)		NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CACCAACGCTGACATCCTGAT	0.468000													6	13					0	0	1	0	0
MIR4485	100616263	broad.mit.edu	37	MT	2087	2087	+	RNA	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrM:2087T>C	ENST00000387347.2	+	0	417					NR_039705.1																						TCCCCTTGTAAATTTAACTGT	0.408000													54	6					0	0	1	0	0
PLEKHN1	84069	broad.mit.edu	37	1	909268	909268	+	Missense_Mutation	SNP	C	C	T	rs140958781	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:909268C>T	ENST00000379409.2	+	13	1676	c.1646C>T	c.(1645-1647)tCg>tTg	p.S549L	PLEKHN1_ENST00000379407.3_Missense_Mutation_p.S462L|PLEKHN1_ENST00000379410.3_Missense_Mutation_p.S497L			Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N member 1	549										central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	9	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCACTCCCCTCGGTGCCTGTG	0.697000													28	75					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45550606	45550606	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:45550606C>G	ENST00000291576.7	+	21	2840	c.2713C>G	c.(2713-2715)Ctg>Gtg	p.L905V		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	905						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CAGCCTGCATCTGCTTGGAGG	0.582000													53	60					0	0	1	0	0
C7orf10	79783	broad.mit.edu	37	7	40174619	40174619	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:40174619G>C	ENST00000309930.5	+	1	45	c.21G>C	c.(19-21)gcG>gcC	p.A7A	C7orf10_ENST00000401647.2_Silent_p.A7A|C7orf10_ENST00000540834.1_5'UTR|C7orf10_ENST00000335693.4_Silent_p.A7A	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	7							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						AGACGCACGCGATGCTGGCGA	0.756000													5	10					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	436766	436766	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:436766C>A	ENST00000338977.5	-	2	1502	c.1454G>T	c.(1453-1455)gGc>gTc	p.G485V	ZNF721_ENST00000506646.1_Intron|ZNF721_ENST00000511833.2_Missense_Mutation_p.G497V|ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000507078.1_Intron					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						GGGTTTCTCGCCAGTATGAAT	0.383000													11	41					9.31168e-06	9.53606e-06	1	1	0
PAN2	9924	broad.mit.edu	37	12	56718262	56718262	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:56718262G>A	ENST00000425394.2	-	12	2120	c.1744C>T	c.(1744-1746)Cgg>Tgg	p.R582W	PAN2_ENST00000440411.3_Missense_Mutation_p.R582W|PAN2_ENST00000257931.5_Missense_Mutation_p.R582W|PAN2_ENST00000548043.1_Missense_Mutation_p.R582W	NM_001127460.2	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	582					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CGGAATGCCCGAAGAAAATTA	0.498000													10	5					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35928812	35928812	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:35928812G>C	ENST00000490799.1	-	13	1879	c.1526C>G	c.(1525-1527)tCa>tGa	p.S509*	SLC26A8_ENST00000394602.2_Nonsense_Mutation_p.S404*|SLC26A8_ENST00000355574.2_Nonsense_Mutation_p.S509*	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	509					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						AGAAACTACTGAGATAATTAG	0.413000													6	20					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34932240	34932240	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:34932240C>T	ENST00000300278.4	+	7	6744	c.6715C>T	c.(6715-6717)Cat>Tat	p.H2239Y	SON_ENST00000356577.4_Intron|SON_ENST00000290239.6_Intron|SON_ENST00000381692.2_Intron	NM_032195.1	NP_115571	P18583	SON_HUMAN	SON DNA binding protein	0					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						CGCAGCTTCTCATTTGACAGT	0.448000													4	19					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47767334	47767334	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:47767334G>A	ENST00000360380.3	-	6	715	c.352C>T	c.(352-354)Ctt>Ttt	p.L118F	STIL_ENST00000371877.3_Missense_Mutation_p.L118F|STIL_ENST00000243182.6_Missense_Mutation_p.L118F|STIL_ENST00000396221.2_Missense_Mutation_p.L118F|STIL_ENST00000337817.5_Missense_Mutation_p.L118F	NM_001282936.1	NP_001269865.1	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	118					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TCCCCAGGAAGAGAAGCAGTA	0.388000													12	14					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													5	120					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	88052994	88052994	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:88052994G>C	ENST00000307808.6	+	17	3550	c.3130G>C	c.(3130-3132)Gag>Cag	p.E1044Q	AFF1_ENST00000544085.1_Missense_Mutation_p.E682Q|AFF1_ENST00000395146.4_Missense_Mutation_p.E1051Q	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	1044						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCCAACACAAGAGAAAATATT	0.308000													3	14					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4711446	4711446	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:4711446G>A	ENST00000302640.8	+	18	2300	c.1950G>A	c.(1948-1950)ctG>ctA	p.L650L	ITPR1_ENST00000456211.2_Silent_p.L650L|ITPR1_ENST00000357086.4_Silent_p.L665L|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000443694.2_Silent_p.L650L|ITPR1_ENST00000354582.6_Silent_p.L665L|ITPR1_ENST00000423119.2_Silent_p.L665L	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	665					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGACATCCTGATTGAGACCA	0.463000													5	12					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183208644	183208644	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:183208644G>C	ENST00000264144.4	+	20	3080	c.3015G>C	c.(3013-3015)caG>caC	p.Q1005H	LAMC2_ENST00000461729.1_3'UTR|LAMC2_ENST00000493293.1_Missense_Mutation_p.Q1005H	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	1005	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CTGATGCACAGAGGGCAAAGA	0.537000													31	78					0	0	1	0	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293573	71293573	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:71293573G>C	ENST00000398530.1	-	1	348	c.311C>G	c.(310-312)tCc>tGc	p.S104C	KRTAP5-11_ENST00000526239.1_Intron|AP000867.1_ENST00000343767.3_Intron	NM_001005405.2	NP_001005405.1	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	104	6 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						ggagcagctggactggcagca	0.617000													65	149					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41583422	41583422	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:41583422C>T	ENST00000396942.1	-	6	552	c.469G>A	c.(469-471)Gag>Aag	p.E157K	ANK1_ENST00000352337.4_Missense_Mutation_p.E157K|ANK1_ENST00000396945.1_Missense_Mutation_p.E157K|ANK1_ENST00000379758.2_Missense_Mutation_p.E157K|ANK1_ENST00000347528.4_Missense_Mutation_p.E157K|ANK1_ENST00000265709.8_Missense_Mutation_p.E190K|ANK1_ENST00000289734.7_Missense_Mutation_p.E157K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	157	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACGACGTTCTCATGGCCCTGC	0.662000													26	18					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800241	27800241	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:27800241G>A	ENST00000408964.2	+	1	853	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	268										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GATTACTCCGGAACTCAAGCA	0.463000													27	37					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65154292	65154292	+	RNA	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:65154292C>T	ENST00000430126.2	+	0	776																											CAGAGATATTCGAGAGGCTCT	0.403000													5	15					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86010686	86010686	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:86010686G>C	ENST00000383699.3	+	8	1486	c.859G>C	c.(859-861)Ggt>Cgt	p.G287R	CADM2_ENST00000407528.2_Missense_Mutation_p.G278R|CADM2_ENST00000405615.2_Missense_Mutation_p.G280R	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	278	Ig-like C2-type 2.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GGTTGTGAGTGGTAGGGAGCT	0.433000													26	83					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29106036	29106036	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:29106036G>A	ENST00000544772.1	-	8	1577	c.141C>T	c.(139-141)ctC>ctT	p.L47L	CHEK2_ENST00000464581.1_5'UTR|CHEK2_ENST00000403642.1_Silent_p.L177L|CHEK2_ENST00000382578.1_Silent_p.L177L|CHEK2_ENST00000348295.3_Silent_p.L268L|CHEK2_ENST00000328354.6_Silent_p.L268L|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Silent_p.L268L|CHEK2_ENST00000382566.1_Silent_p.L268L|CHEK2_ENST00000382580.2_Silent_p.L311L|CHEK2_ENST00000405598.1_Silent_p.L268L|CHEK2_ENST00000404276.1_Silent_p.L268L	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	268					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						TTTCAACATTGAGAGCTGGGT	0.264000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					7	5					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231318	29231318	+	RNA	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:29231318G>C	ENST00000441381.1	+	0	79																		p.S180F(1)									GACCATTGCAGATATTTCACA	0.433000													12	25					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157389	65157389	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157389G>C	ENST00000323544.4	+	6	903	c.775G>C	c.(775-777)Gag>Cag	p.E259Q	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	259	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						CAGTGGCTCTGAGCAGCCTCC	0.632000													25	32					0	0	1	0	0
RFWD2	64326	broad.mit.edu	37	1	176050418	176050418	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:176050418T>C	ENST00000367669.3	-	11	1661	c.1147A>G	c.(1147-1149)Agt>Ggt	p.S383G	RFWD2_ENST00000308769.8_Missense_Mutation_p.S359G	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	383					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						GCAGTTCGACTGTCATCTATA	0.328000													9	24					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46308019	46308019	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:46308019C>G	ENST00000221538.3	-	3	1286	c.1144G>C	c.(1144-1146)Gag>Cag	p.E382Q	RSPH6A_ENST00000600188.1_Missense_Mutation_p.E118Q|RSPH6A_ENST00000597055.1_Missense_Mutation_p.E382Q	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	382	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tccATGACCTCGCCACCTTCC	0.657000													12	20					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79284125	79284125	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284125C>T	ENST00000419573.3	-	22	3361	c.3087G>A	c.(3085-3087)gtG>gtA	p.V1029V	RASGRF1_ENST00000394745.3_Silent_p.V245V|RASGRF1_ENST00000558480.2_Silent_p.V1013V|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1031					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCTCAGCCTTCACGCCTTCAG	0.542000													8	29					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127670203	127670203	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:127670203G>C	ENST00000249363.3	-	2	748	c.491C>G	c.(490-492)tCt>tGt	p.S164C	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	164						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		GAAGGCGTAAGAGGGGATGCT	0.572000													30	135					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62871220	62871220	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:62871220C>T	ENST00000536311.1	+	22	3646	c.3282C>T	c.(3280-3282)ctC>ctT	p.L1094L	MYT1_ENST00000328439.1_Silent_p.L1067L			Q01538	MYT1_HUMAN	myelin transcription factor 1	1067					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCAGGCCCTCATCCAAAGTC	0.592000													40	260					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49224075	49224075	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:49224075G>C	ENST00000222145.4	-	12	3076	c.2872C>G	c.(2872-2874)Ccc>Gcc	p.P958A		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	958					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GTGGCCACGGGAGGCCCATGG	0.602000													87	150					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89521722	89521722	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:89521722C>T	ENST00000370473.4	-	8	1564	c.1345G>A	c.(1345-1347)Gag>Aag	p.E449K		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	449					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		CTCGGTTCCTCATAGTACTTT	0.453000													14	86					0	0	1	0	0
YAF2	10138	broad.mit.edu	37	12	42554413	42554413	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:42554413G>A	ENST00000327791.4	-	5	516	c.449C>T	c.(448-450)tCa>tTa	p.S150L	YAF2_ENST00000380790.4_Missense_Mutation_p.S132L|YAF2_ENST00000380788.3_Missense_Mutation_p.S165L|YAF2_ENST00000534854.2_Missense_Mutation_p.S174L|YAF2_ENST00000442791.3_Missense_Mutation_p.S198L			Q8IY57	YAF2_HUMAN	YY1 associated factor 2	174					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|zinc ion binding			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)	8	all_cancers(12;0.000425)	Lung NSC(34;0.0402)|all_lung(34;0.057)		GBM - Glioblastoma multiforme(48;0.0514)		TCCATTCAATGATGAGGCTTC	0.423000													8	6					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32930745	32930745	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:32930745C>G	ENST00000342179.5	+	8	999	c.784C>G	c.(784-786)Caa>Gaa	p.Q262E	DPY19L3_ENST00000392250.2_Missense_Mutation_p.Q262E|DPY19L3_ENST00000586987.1_Missense_Mutation_p.Q262E	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	262						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					GCAATTTAATCAATTTATGAT	0.393000													44	48					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11964910	11964910	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:11964910C>T	ENST00000256720.2	+	20	2759	c.2666C>T	c.(2665-2667)tCa>tTa	p.S889L	LPIN1_ENST00000396097.1_Missense_Mutation_p.S619L|LPIN1_ENST00000396099.1_Missense_Mutation_p.S931L|LPIN1_ENST00000449576.2_Missense_Mutation_p.S974L|LPIN1_ENST00000425416.2_Missense_Mutation_p.S895L|LPIN1_ENST00000404113.2_Missense_Mutation_p.S390L	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	889					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CATTCTGCCTCAGCGTAAAAT	0.517000													12	35					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240255999	240255999	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:240255999C>G	ENST00000319653.9	+	1	820	c.590C>G	c.(589-591)tCa>tGa	p.S197*		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	197					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GATTTGCTTTCAGACATCCAG	0.617000													7	38					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152690184	152690184	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:152690184G>C	ENST00000367255.5	-	61	10331	c.9730C>G	c.(9730-9732)Caa>Gaa	p.Q3244E	SYNE1_ENST00000341594.5_Missense_Mutation_p.Q3283E|SYNE1_ENST00000265368.4_Missense_Mutation_p.Q3244E|SYNE1_ENST00000448038.1_Missense_Mutation_p.Q3251E|SYNE1_ENST00000423061.1_Missense_Mutation_p.Q3251E	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3244					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGCAGCTTGTCCTTCCCAC	0.498000										HNSCC(10;0.0054)			9	34					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25438416	25438416	+	RNA	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:25438416G>C	ENST00000424208.1	+	0	1275				SNHG14_ENST00000414175.1_RNA	NR_003305.1																						GCTGTGATGAGCACATCCGGG	0.572000													26	89					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	118030457	118030457	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:118030457C>G	ENST00000439649.3	-	3	578	c.211G>C	c.(211-213)Gag>Cag	p.E71Q	GFRA1_ENST00000369236.1_Missense_Mutation_p.E71Q|GFRA1_ENST00000355422.6_Missense_Mutation_p.E71Q	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	71					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTGCGGCACTCATCCTTGGCC	0.607000													33	49					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139887	50139887	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:50139887G>C	ENST00000371564.3	-	2	1112	c.893C>G	c.(892-894)gCt>gGt	p.A298G	NFATC2_ENST00000396009.3_Missense_Mutation_p.A298G|NFATC2_ENST00000609507.1_Missense_Mutation_p.A79G|NFATC2_ENST00000414705.1_Missense_Mutation_p.A278G|NFATC2_ENST00000609943.1_Missense_Mutation_p.A278G|NFATC2_ENST00000610033.1_Missense_Mutation_p.A79G	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	298					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGCAGAGCCAGCCACAGGGGG	0.706000													13	20					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141244913	141244913	+	Missense_Mutation	SNP	C	C	T	rs149443924		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:141244913C>T	ENST00000287008.3	-	3	1130	c.983G>A	c.(982-984)cGt>cAt	p.R328H	PCDH1_ENST00000456271.1_Missense_Mutation_p.R316H|PCDH1_ENST00000511044.1_5'UTR|PCDH1_ENST00000536585.1_Missense_Mutation_p.R306H|PCDH1_ENST00000503492.1_Intron|PCDH1_ENST00000394536.3_Missense_Mutation_p.R328H	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	328	Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCGAAGAAGACGCCTCACAAC	0.537000													44	44					0	0	1	0	0
NUS1	116150	broad.mit.edu	37	6	118028140	118028140	+	Missense_Mutation	SNP	C	C	T	rs150953098		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:118028140C>T	ENST00000368494.3	+	5	1013	c.844C>T	c.(844-846)Cgt>Tgt	p.R282C		NM_138459.3	NP_612468.1	Q96E22	NGBR_HUMAN	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	282					angiogenesis|cell differentiation	integral to membrane	receptor activity|transferase activity, transferring alkyl or aryl (other than methyl) groups			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|prostate(2)	8		all_cancers(87;0.0395)|all_epithelial(87;0.0301)		GBM - Glioblastoma multiforme(226;0.02)|OV - Ovarian serous cystadenocarcinoma(136;0.115)|all cancers(137;0.146)		CTCTGCCCTTCGTCAATATGC	0.433000													20	28					0	0	1	0	0
SLC25A30	253512	broad.mit.edu	37	13	45973211	45973211	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:45973211G>C	ENST00000539591.1	-	7	627	c.464C>G	c.(463-465)tCa>tGa	p.S155*				Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	206					mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		GGTGAAGCTTGAGCTATAAAG	0.463000													7	34					0	0	1	0	0
MAP2K3	5606	broad.mit.edu	37	17	21207742	21207742	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:21207742G>A	ENST00000342679.4	+	8	822	c.573G>A	c.(571-573)gtG>gtA	p.V191V	MAP2K3_ENST00000316920.6_Silent_p.V162V|MAP2K3_ENST00000361818.5_Silent_p.V162V	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	191	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TGGCAGATGTGAAGCCCTCCA	0.577000													36	95					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7625568	7625568	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:7625568G>A	ENST00000221249.6	+	32	4051	c.3620G>A	c.(3619-3621)gGa>gAa	p.G1207E	PNPLA6_ENST00000450331.3_Missense_Mutation_p.G1207E|PNPLA6_ENST00000414982.3_Missense_Mutation_p.G1255E|PNPLA6_ENST00000600737.1_Missense_Mutation_p.G1245E|PNPLA6_ENST00000545201.2_Missense_Mutation_p.G1180E	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	1246					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						GCGGTGTTTGGAGGCTGGAGC	0.587000													27	20					0	0	1	0	0
LYPD6B	130576	broad.mit.edu	37	2	150071149	150071149	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:150071149G>A	ENST00000409642.3	+	7	950	c.549G>A	c.(547-549)caG>caA	p.Q183Q	LYPD6B_ENST00000409876.1_Silent_p.Q159Q|LYPD6B_ENST00000280115.7_Silent_p.Q183Q|LYPD6B_ENST00000409029.1_Silent_p.Q159Q|LYPD6B_ENST00000498249.1_3'UTR	NM_177964.3	NP_808879.2	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	159						anchored to membrane|plasma membrane				endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11						TGCACGCTCAGAGAACATCTG	0.493000													63	148					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148800826	148800826	+	Silent	SNP	G	G	A	rs142180575		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:148800826G>A	ENST00000378061.2	-	4	2269	c.2137C>T	c.(2137-2139)Ctg>Ttg	p.L713L		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	713					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGAAGGCACAGATGGGCCTTC	0.552000													19	27					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17153011	17153011	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:17153011C>T	ENST00000377833.4	-	9	987	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	308	EGF-like 4; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATCTCACATTCATTGATATCT	0.458000													14	70					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44949017	44949017	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:44949017G>A	ENST00000377967.4	+	25	3619	c.3578G>A	c.(3577-3579)tGg>tAg	p.W1193*	KDM6A_ENST00000382899.4_Nonsense_Mutation_p.W1200*|KDM6A_ENST00000543216.1_Nonsense_Mutation_p.W1114*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.W1148*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1193	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						ATGGGTTCTTGGTGGCCCAAT	0.353000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								9	1					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14633975	14633975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:14633975C>T	ENST00000544627.1	+	13	3480	c.3160C>T	c.(3160-3162)Cag>Tag	p.Q1054*	ATF7IP_ENST00000543189.1_Nonsense_Mutation_p.Q1045*|ATF7IP_ENST00000540793.1_Nonsense_Mutation_p.Q1046*|ATF7IP_ENST00000536444.1_Nonsense_Mutation_p.Q1045*|ATF7IP_ENST00000261168.4_Nonsense_Mutation_p.Q1046*			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	1046					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TCCAGTAACTCAGGTGACCAC	0.453000													37	40					0	0	1	0	0
DUSP6	1848	broad.mit.edu	37	12	89743339	89743339	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:89743339C>T	ENST00000279488.7	-	3	2070		c.e3-1		DUSP6_ENST00000547140.1_Splice_Site|DUSP6_ENST00000547291.1_Splice_Site|DUSP6_ENST00000308385.6_Splice_Site	NM_001946.2	NP_001937.2	Q16828	DUS6_HUMAN	dual specificity phosphatase 6						dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(5)|lung(8)|skin(2)|urinary_tract(1)	16						CGGGCTTCATCTGTGAACACA	0.418000													14	23					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52865006	52865006	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:52865006G>T	ENST00000252250.6	-	5	1034	c.987C>A	c.(985-987)gaC>gaA	p.D329E		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	329	Linker 12.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		TGCTGTCCAGGTCCAGGTTGC	0.562000													72	106					1.17611e-34	1.25748e-34	1	1	0
NMU	10874	broad.mit.edu	37	4	56475309	56475309	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:56475309A>G	ENST00000264218.3	-	4	362	c.257T>C	c.(256-258)aTg>aCg	p.M86T	NMU_ENST00000507338.1_Missense_Mutation_p.M86T|NMU_ENST00000515325.1_5'UTR|NMU_ENST00000505262.1_Missense_Mutation_p.M86T|NMU_ENST00000511469.1_Missense_Mutation_p.M70T	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	86					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		TAGCATTCCCATAATCATAAA	0.358000													41	24					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12880633	12880633	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:12880633G>A	ENST00000155926.4	+	3	2164	c.745G>A	c.(745-747)Gtg>Atg	p.V249M	TRIB2_ENST00000381465.2_Missense_Mutation_p.V113M	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	249	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CACCATGTTGGTGGGGCGGTA	0.582000													32	22					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201749603	201749603	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749603C>G	ENST00000367296.4	+	4	1701	c.1281C>G	c.(1279-1281)ctC>ctG	p.L427L	NAV1_ENST00000367302.1_Silent_p.L440L|NAV1_ENST00000295624.6_Silent_p.L427L|NAV1_ENST00000367297.4_Silent_p.L427L|NAV1_ENST00000367295.1_Silent_p.L36L|NAV1_ENST00000367300.3_Silent_p.L427L|IPO9-AS1_ENST00000413035.1_RNA	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	427					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CAGACAATCTCAGTTCAGAAG	0.488000													32	82					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125261952	125261952	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:125261952C>T	ENST00000431078.1	+	8	1507	c.1143C>T	c.(1141-1143)ccC>ccT	p.P381P		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	381	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGCTGCTGCCCGGCACCCCCC	0.512000													42	25					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12202457	12202457	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:12202457G>C	ENST00000263932.2	+	15	1879	c.1657G>C	c.(1657-1659)Gag>Cag	p.E553Q	TNFRSF8_ENST00000479933.2_3'UTR|TNFRSF8_ENST00000417814.2_Missense_Mutation_p.E441Q|TNFRSF8_ENST00000413146.2_Missense_Mutation_p.E90Q	NM_001243.3|NM_001281430.1	NP_001234.2|NP_001268359.1	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	553					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGGAGCTGGAGGCGGACCA	0.652000													13	31					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86087957	86087957	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86087957C>G	ENST00000330753.4	+	2	866	c.99C>G	c.(97-99)ctC>ctG	p.L33L	FLRT2_ENST00000554746.1_Silent_p.L33L	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	33					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGTCCAAACTCCTGGCCTGCC	0.547000													53	50					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41573889	41573889	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573889C>G	ENST00000263253.7	+	31	7393	c.6174C>G	c.(6172-6174)ctC>ctG	p.L2058L	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2058	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TGCGGACTCTCAGGTCTCCCA	0.552000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				52	24					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104341191	104341191	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:104341191G>A	ENST00000299767.5	+	17	2547	c.2365G>A	c.(2365-2367)Gaa>Aaa	p.E789K		NM_003299.2	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	789					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	aacagatgaagaagaagaaAC	0.423000													14	9					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41572404	41572404	+	Nonsense_Mutation	SNP	C	C	T	rs139310551		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41572404C>T	ENST00000263253.7	+	30	6152	c.4933C>T	c.(4933-4935)Cga>Tga	p.R1645*	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1645	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.R1645R(1)		NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CTCTTCACTCCGAAGAGCCCA	0.557000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				34	13					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41573079	41573079	+	Silent	SNP	C	C	G	rs143551315	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573079C>G	ENST00000263253.7	+	31	6583	c.5364C>G	c.(5362-5364)ctC>ctG	p.L1788L	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1788	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TCATTGCCCTCTGCTGCTACC	0.572000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				54	23					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67331452	67331452	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:67331452C>T	ENST00000304372.5	-	7	1156	c.1101G>A	c.(1099-1101)ttG>ttA	p.L367L		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	367						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GATGAGTCTTCAAAGCAACTT	0.493000													17	30					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10073543	10073543	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:10073543G>A	ENST00000264828.3	-	65	4888	c.4803C>T	c.(4801-4803)tcC>tcT	p.S1601S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1601	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GCTTTTCCTTGGACCAGGAGG	0.532000													9	14					0	0	1	0	0
CLIC5	53405	broad.mit.edu	37	6	45922939	45922939	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:45922939G>A	ENST00000185206.6	-	2	735	c.583C>T	c.(583-585)Cag>Tag	p.Q195*	CLIC5_ENST00000339561.6_Nonsense_Mutation_p.Q36*|CLIC5_ENST00000544153.1_Nonsense_Mutation_p.Q36*	NM_001114086.1	NP_001107558.1	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5	195					female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	13						AAGAGGCGCTGAGAGAAAGGA	0.478000													15	11					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79284109	79284109	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284109C>G	ENST00000419573.3	-	22	3377	c.3103G>C	c.(3103-3105)Gaa>Caa	p.E1035Q	RASGRF1_ENST00000394745.3_Missense_Mutation_p.E251Q|RASGRF1_ENST00000558480.2_Missense_Mutation_p.E1019Q|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1037					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GAGTGGTTTTCAAAGGGCTCA	0.552000													13	38					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193384092	193384092	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:193384092G>C	ENST00000361510.2	+	28	3020	c.2786G>C	c.(2785-2787)tGc>tCc	p.C929S	OPA1_ENST00000361828.2_Missense_Mutation_p.C892S|OPA1_ENST00000361715.2_Missense_Mutation_p.C893S|OPA1_ENST00000361908.3_Missense_Mutation_p.C911S|OPA1_ENST00000392438.3_Missense_Mutation_p.C874S|OPA1_ENST00000361150.2_Missense_Mutation_p.C875S	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	874					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CAGTTGGAATGCAATGATGTG	0.358000													21	56					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183209259	183209259	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:183209259G>C	ENST00000264144.4	+	21	3219	c.3154G>C	c.(3154-3156)Gag>Cag	p.E1052Q	LAMC2_ENST00000461729.1_3'UTR|LAMC2_ENST00000493293.1_Missense_Mutation_p.E1052Q	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	1052	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						TCTGAAGAGTGAGATGAGGGA	0.507000													19	74					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11136115	11136115	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:11136115G>C	ENST00000358026.2	+	22	3383	c.3099G>C	c.(3097-3099)aaG>aaC	p.K1033N	SMARCA4_ENST00000589677.1_Missense_Mutation_p.K1033N|SMARCA4_ENST00000429416.3_Missense_Mutation_p.K1033N|SMARCA4_ENST00000413806.3_Missense_Mutation_p.K1033N|SMARCA4_ENST00000541122.2_Missense_Mutation_p.K1033N|SMARCA4_ENST00000450717.3_Missense_Mutation_p.K1033N|SMARCA4_ENST00000444061.3_Missense_Mutation_p.K1033N|SMARCA4_ENST00000344626.4_Missense_Mutation_p.K1033N|SMARCA4_ENST00000590574.1_Missense_Mutation_p.K1033N	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1033					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCGGCACCAAGACCCTGATGA	0.632000			"""F, N, Mis"""		NSCLC								29	118					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8088834	8088834	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:8088834G>C	ENST00000332175.8	+	11	2878	c.1841G>C	c.(1840-1842)aGa>aCa	p.R614T	PTPRM_ENST00000400053.4_Missense_Mutation_p.R552T|PTPRM_ENST00000444013.1_Missense_Mutation_p.R401T|PTPRM_ENST00000400060.4_Missense_Mutation_p.R614T|PTPRM_ENST00000580170.1_Missense_Mutation_p.R614T|PTPRM_ENST00000578571.1_3'UTR	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	614	Fibronectin type-III 4.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GCCCACAGCAGAGGAGCACCT	0.458000													38	15					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49762735	49762735	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:49762735G>A	ENST00000492622.2	+	17	2215	c.1910G>A	c.(1909-1911)cGa>cAa	p.R637Q	FNDC3A_ENST00000541916.1_Missense_Mutation_p.R637Q|FNDC3A_ENST00000398316.3_Missense_Mutation_p.R581Q	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	637	Fibronectin type-III 4.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TATCGTTTACGAGTTTACTGC	0.413000													24	157					0	0	1	0	0
SOX1	6656	broad.mit.edu	37	13	112722161	112722161	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:112722161C>T	ENST00000330949.1	+	1	249	c.189C>T	c.(187-189)cgC>cgT	p.R63R		NM_005986.2	NP_005977.2	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	63					chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)	4	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		TGTGGTCCCGCGGGCAGCGGC	0.716000													19	32					0	0	1	0	0
GRINA	2907	broad.mit.edu	37	8	145066426	145066426	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:145066426C>T	ENST00000313269.5	+	5	985	c.707C>T	c.(706-708)gCc>gTc	p.A236V	GRINA_ENST00000395068.4_Missense_Mutation_p.A236V	NM_000837.1	NP_000828.1	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	236						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	9	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCTGACCGCCAGCCTGTCG	0.627000													16	112					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59630175	59630175	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:59630175C>G	ENST00000257264.3	-	3	384	c.280G>C	c.(280-282)Gag>Cag	p.E94Q	TCN1_ENST00000532419.1_5'UTR	NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	94					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGGCAAGCTCTCCCGAGCTT	0.383000													15	26					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159831861	159831861	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:159831861C>T	ENST00000297151.4	-	14	1806	c.1419G>A	c.(1417-1419)gaG>gaA	p.E473E		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	473					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCAGTTATCTCATTTATAA	0.348000													11	11					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066120	168066120	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:168066120G>C	ENST00000367838.1	-	5	1038	c.725C>G	c.(724-726)tCc>tGc	p.S242C	GPR161_ENST00000546300.1_Missense_Mutation_p.S128C|GPR161_ENST00000367836.1_Missense_Mutation_p.S110C|GPR161_ENST00000539777.1_Missense_Mutation_p.S164C|GPR161_ENST00000271357.5_Missense_Mutation_p.S242C|GPR161_ENST00000367835.1_Missense_Mutation_p.S242C|GPR161_ENST00000361697.2_Missense_Mutation_p.S242C|GPR161_ENST00000537209.1_Missense_Mutation_p.S262C	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	242					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					GGAGGTGCTGGAGTTCTTCCT	0.602000													89	106					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801778	148801778	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:148801778G>A	ENST00000378061.2	-	4	1317	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	395					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTTGTAGATGAATTTCCTGC	0.532000													55	92					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088862	86088862	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86088862G>T	ENST00000330753.4	+	2	1771	c.1004G>T	c.(1003-1005)cGg>cTg	p.R335L	FLRT2_ENST00000554746.1_Missense_Mutation_p.R335L	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	335	LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CTCAACGTGCGGGGTTTCATG	0.507000													87	93					4.44732e-65	4.83096e-65	1	1	0
TNPO1	3842	broad.mit.edu	37	5	72189254	72189254	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:72189254G>A	ENST00000337273.5	+	17	2373	c.1947G>A	c.(1945-1947)atG>atA	p.M649I	TNPO1_ENST00000454282.1_Missense_Mutation_p.M599I|TNPO1_ENST00000506351.2_Missense_Mutation_p.M641I|TNPO1_ENST00000523768.1_Missense_Mutation_p.M599I	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	649					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		AAGATTTTATGATAGTGGCTC	0.378000													4	25					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201749677	201749677	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749677C>T	ENST00000367296.4	+	4	1775	c.1355C>T	c.(1354-1356)tCa>tTa	p.S452L	NAV1_ENST00000367302.1_Missense_Mutation_p.S465L|NAV1_ENST00000295624.6_Missense_Mutation_p.S452L|NAV1_ENST00000367297.4_Missense_Mutation_p.S452L|NAV1_ENST00000367295.1_Missense_Mutation_p.S61L|NAV1_ENST00000367300.3_Missense_Mutation_p.S452L|IPO9-AS1_ENST00000413035.1_RNA	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	452					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CGCAGGAACTCAACAATAGTG	0.498000													22	74					0	0	1	0	0
DTX2	113878	broad.mit.edu	37	7	76112191	76112191	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:76112191G>T	ENST00000324432.5	+	5	1145	c.635G>T	c.(634-636)gGc>gTc	p.G212V	DTX2_ENST00000446820.2_Missense_Mutation_p.G212V|DTX2_ENST00000307569.8_Missense_Mutation_p.G212V|DTX2_ENST00000413936.2_Missense_Mutation_p.G212V|DTX2_ENST00000446600.1_Missense_Mutation_p.G121V|DTX2_ENST00000430490.2_Missense_Mutation_p.G212V	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	212					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						CCCGTGTCAGGCCGCTACCGC	0.662000													45	444					1.00246e-47	1.0786e-47	1	1	0
SPTB	6710	broad.mit.edu	37	14	65260362	65260362	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:65260362G>C	ENST00000389722.3	-	13	2072	c.2019C>G	c.(2017-2019)ctC>ctG	p.L673L	SPTB_ENST00000556626.1_Silent_p.L673L|SPTB_ENST00000389720.3_Silent_p.L673L|SPTB_ENST00000542895.1_Silent_p.L673L|SPTB_ENST00000389721.5_Silent_p.L673L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	673					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCTGTAAGATGAGCACACTGG	0.547000													11	22					0	0	1	0	0
ALAS1	211	broad.mit.edu	37	3	52245397	52245397	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:52245397C>G	ENST00000394965.2	+	10	1789	c.1429C>G	c.(1429-1431)Ctg>Gtg	p.L477V	ALAS1_ENST00000310271.2_Missense_Mutation_p.L477V|ALAS1_ENST00000469224.1_Missense_Mutation_p.L477V|ALAS1_ENST00000484952.1_Missense_Mutation_p.L477V	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1	477					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CACCACCTCTCTGCCACCCAT	0.592000													20	9					0	0	1	0	0
NSUN6	221078	broad.mit.edu	37	10	18905124	18905124	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:18905124G>A	ENST00000377304.4	-	4	828	c.410C>T	c.(409-411)tCa>tTa	p.S137L		NM_182543.2	NP_872349.1	Q8TEA1	NSUN6_HUMAN	NOP2/Sun domain family, member 6	137	PUA.						methyltransferase activity|RNA binding			endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15						TTGTGATGCTGACACAATTCC	0.343000													39	10					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53620499	53620499	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:53620499G>C	ENST00000342160.3	-	31	4023	c.3566C>G	c.(3565-3567)tCa>tGa	p.S1189*	HUWE1_ENST00000218328.8_Nonsense_Mutation_p.S1189*|HUWE1_ENST00000262854.6_Nonsense_Mutation_p.S1189*			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1189					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AGGCAAGTCTGAGTGTTCCAA	0.453000													18	25					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245337	183245337	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:183245337C>T	ENST00000511685.1	+	2	287	c.164C>T	c.(163-165)tCg>tTg	p.S55L	TENM3_ENST00000406950.2_Missense_Mutation_p.S55L					teneurin transmembrane protein 3																		CATGATTCCTCGCGGCTGCTT	0.483000													20	57					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185155308	185155308	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:185155308C>T	ENST00000265026.3	+	3	883	c.549C>T	c.(547-549)ttC>ttT	p.F183F	MAP3K13_ENST00000446828.1_Intron|MAP3K13_ENST00000535426.1_Silent_p.F39F|MAP3K13_ENST00000443863.1_Silent_p.F39F|MAP3K13_ENST00000424227.1_Silent_p.F183F	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	183	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAGCGGTCTTCTTGGGCAAGT	0.498000													49	89					0	0	1	0	0
SNX29P2	440352	broad.mit.edu	37	16	29367202	29367202	+	RNA	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:29367202G>A	ENST00000398878.3	+	0	1028				SNX29P2_ENST00000507381.1_RNA																							GACGTGGGCCGGGGCCGCACC	0.657000													22	68					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180904553	180904553	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:180904553G>A	ENST00000367588.4	+	5	1563	c.1508G>A	c.(1507-1509)cGg>cAg	p.R503Q	KIAA1614_ENST00000367587.1_Missense_Mutation_p.R124Q	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	503										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GGGGCTCCCCGGCTCCGGGAC	0.741000													4	23					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162750019	162750019	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:162750019C>A	ENST00000367922.3	+	19	2989	c.2551C>A	c.(2551-2553)Caa>Aaa	p.Q851K	DDR2_ENST00000367921.3_Missense_Mutation_p.Q851K	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2						cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCTGCTCCTTCAACAAGGCGA	0.527000													12	93					2.68362e-12	2.82486e-12	1	1	0
PLEKHO2	80301	broad.mit.edu	37	15	65157595	65157595	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157595G>C	ENST00000323544.4	+	6	1109	c.981G>C	c.(979-981)gaG>gaC	p.E327D	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	327	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCATGGGTGAGATGCAGGCTT	0.597000													8	21					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17948866	17948866	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:17948866T>C	ENST00000458235.1	-	12	1675	c.1576A>G	c.(1576-1578)Aac>Gac	p.N526D	JAK3_ENST00000527670.1_Missense_Mutation_p.N526D|JAK3_ENST00000534444.1_Missense_Mutation_p.N526D	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	526	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						TGGCCCAGGTTCTCATGCTGA	0.587000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								18	44					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107520009	107520009	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:107520009A>G	ENST00000416476.2	+	16	1830	c.1610A>G	c.(1609-1611)aAt>aGt	p.N537S	BBX_ENST00000325805.8_Silent_p.K873K|BBX_ENST00000415149.2_Silent_p.K843K|BBX_ENST00000406780.1_Silent_p.K843K|BBX_ENST00000402543.1_Silent_p.K823K			Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	0	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCAATGACAAATGCTCACACA	0.512000													43	32					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41767359	41767359	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:41767359C>A	ENST00000379483.3	-	1	1343	c.1035G>T	c.(1033-1035)atG>atT	p.M345I		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	345							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		AGAAGATCACCATCTCCTTGG	0.507000													11	13					5.03518e-11	5.26758e-11	1	1	0
URGCP	55665	broad.mit.edu	37	7	43916935	43916935	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:43916935G>C	ENST00000336086.6	-	4	4234	c.1998C>G	c.(1996-1998)ctC>ctG	p.L666L	URGCP_ENST00000497914.1_5'UTR|URGCP-MRPS24_ENST00000603700.1_Intron|URGCP_ENST00000223341.7_Silent_p.L666L|URGCP_ENST00000443736.1_Silent_p.L666L|URGCP_ENST00000402306.3_Silent_p.L700L|URGCP_ENST00000453200.1_Silent_p.L709L|URGCP_ENST00000447717.3_Silent_p.L666L			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	709					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACATGGTGTTGAGGAGTGTGG	0.627000													31	123					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141233836	141233836	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:141233836C>T	ENST00000287008.3	-	5	3632	c.3485G>A	c.(3484-3486)gGa>gAa	p.G1162E	PCDH1_ENST00000503492.1_3'UTR	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	0					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CTCCTGCCCTCCTCGGTCCTG	0.677000													6	12					0	0	1	0	0
TNFRSF10A	8797	broad.mit.edu	37	8	23082521	23082521	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:23082521C>G	ENST00000221132.3	-	1	118	c.54G>C	c.(52-54)ccG>ccC	p.P18P	RP11-1149O23.3_ENST00000517774.1_RNA	NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	18					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TCCCGGGATTCGGAGTCACTG	0.632000													14	16					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36370075	36370075	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:36370075C>A	ENST00000221891.4	+	16	2005	c.1813C>A	c.(1813-1815)Cgc>Agc	p.R605S	APLP1_ENST00000586861.1_Missense_Mutation_p.R598S|APLP1_ENST00000537454.2_Missense_Mutation_p.R565S	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	604					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCTGCTCCTGCGCAGGAAGAA	0.657000													23	107					1.85244e-09	1.91438e-09	1	1	0
CDH7	1005	broad.mit.edu	37	18	63511079	63511079	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:63511079C>T	ENST00000536984.2	+	7	1707	c.1013C>T	c.(1012-1014)aCg>aTg	p.T338M	CDH7_ENST00000397968.2_Missense_Mutation_p.T338M|CDH7_ENST00000323011.3_Missense_Mutation_p.T338M			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	338	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				ACAAGTTACACGCTACGGATA	0.418000													11	26					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781491	52781491	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:52781491G>A	ENST00000245457.5	+	1	379	c.225G>A	c.(223-225)gtG>gtA	p.V75V	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	75						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CCGAGCTGGTGTTCACCGACC	0.711000													18	60					0	0	1	0	0
RPN1	6184	broad.mit.edu	37	3	128356705	128356705	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:128356705G>A	ENST00000296255.3	-	3	618	c.570C>T	c.(568-570)aaC>aaT	p.N190N	RPN1_ENST00000497289.1_Silent_p.N18N	NM_002950.3	NP_002941.1	P04843	RPN1_HUMAN	ribophorin I	190					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|stomach(2)	13				GBM - Glioblastoma multiforme(114;0.189)		AGCGCGTGGGGTTCCCCAGCT	0.532000			T	EVI1	AML								23	83					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140299981	140299981	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:140299981G>A	ENST00000296543.5	+	17	2451	c.2128G>A	c.(2128-2130)Gag>Aag	p.E710K	NAA15_ENST00000398947.1_Missense_Mutation_p.E710K	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	710					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						CTGGCTTCATGAGTGTATGAT	0.328000													20	14					0	0	1	0	0
STMN2	11075	broad.mit.edu	37	8	80549051	80549051	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:80549051A>G	ENST00000220876.7	+	2	416	c.34A>G	c.(34-36)Atg>Gtg	p.M12V	STMN2_ENST00000518491.1_Start_Codon_SNP_p.M1V|STMN2_ENST00000518111.1_Missense_Mutation_p.M12V	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	12	Membrane attachment (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CAAGGAAAAAATGAAGGAGCT	0.358000													11	33					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267429	107267429	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:107267429G>C	ENST00000334726.2	+	1	975	c.886G>C	c.(886-888)Gag>Cag	p.E296Q		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ACGGAACAAAGAGGTGAAAGT	0.373000													20	4					0	0	1	0	0
FAM207A	85395	broad.mit.edu	37	21	46363637	46363637	+	Silent	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:46363637C>A	ENST00000291634.6	+	2	216	c.168C>A	c.(166-168)acC>acA	p.T56T	FAM207A_ENST00000397826.3_Silent_p.T56T	NM_058190.2	NP_478070.1	Q9NSI2	CU070_HUMAN	family with sequence similarity 207, member A	56																	TTGCCAGGACCAAGATAGACC	0.552000													29	69					1.04352e-10	1.08833e-10	1	1	0
HAL	3034	broad.mit.edu	37	12	96368046	96368046	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:96368046C>T	ENST00000261208.3	-	21	2306	c.1938G>A	c.(1936-1938)aaG>aaA	p.K646K	HAL_ENST00000541929.1_Silent_p.K438K|HAL_ENST00000538703.1_3'UTR	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	646					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TGGTGGATTTCTTGTGCAGAA	0.438000													20	61					0	0	1	0	0
BBS4	585	broad.mit.edu	37	15	73007669	73007669	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:73007669C>G	ENST00000268057.4	+	5	299	c.258C>G	c.(256-258)tcC>tcG	p.S86S	BBS4_ENST00000395205.2_Silent_p.S94S|BBS4_ENST00000564239.1_3'UTR|BBS4_ENST00000539603.1_Silent_p.S74S|BBS4_ENST00000542334.1_5'UTR	NM_033028.4	NP_149017.2	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	86					adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity			autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(1)	19						TCCAAGAATCCCTAGAACTCT	0.443000									Bardet-Biedl syndrome				13	26					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40913375	40913375	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:40913375G>A	ENST00000346991.5	+	11	1381	c.991G>A	c.(991-993)Gaa>Aaa	p.E331K	CASC5_ENST00000527044.1_3'UTR|CASC5_ENST00000399668.2_Missense_Mutation_p.E305K			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	331	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAACTCACGGGAATCTAAAGG	0.378000													10	26					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650969	90650969	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650969C>G	ENST00000282146.4	+	2	1290	c.849C>G	c.(847-849)atC>atG	p.I283M		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	283						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CTATCCTCATCAAACAGTCCT	0.517000													26	94					0	0	1	0	0
CUTC	51076	broad.mit.edu	37	10	101503808	101503808	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:101503808C>G	ENST00000370476.5	+	5	547	c.418C>G	c.(418-420)Ctg>Gtg	p.L140V		NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	140					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding	p.L140V(1)		breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		TTGCCGCCCTCTGCCAGTCAC	0.348000													23	9					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89924900	89924900	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:89924900G>A	ENST00000534061.1	+	19	2438	c.2208G>A	c.(2206-2208)ctG>ctA	p.L736L	NAALAD2_ENST00000375944.3_3'UTR|NAALAD2_ENST00000321955.4_Silent_p.L703L	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	736					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CAGGAACTCTGAAAGAAGTAT	0.368000													6	17					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													26	5					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218700908	218700908	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:218700908C>T	ENST00000171887.4	-	18	3111	c.2659G>A	c.(2659-2661)Gca>Aca	p.A887T	TNS1_ENST00000430930.1_Missense_Mutation_p.A887T|TNS1_ENST00000419504.1_Missense_Mutation_p.A887T	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	887						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGGGGCTCTGCAGGCTGCTTC	0.582000													6	51					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29824403	29824403	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:29824403G>C	ENST00000300797.6	+	2	202	c.28G>C	c.(28-30)Gag>Cag	p.E10Q	AC009133.20_ENST00000569039.1_RNA|PRRT2_ENST00000358758.7_Missense_Mutation_p.E10Q|PRRT2_ENST00000567659.1_Missense_Mutation_p.E10Q|PRRT2_ENST00000567551.1_3'UTR			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	10					response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						TGAGATCTCTGAGATGAAGGG	0.587000													24	78					0	0	1	0	0
FASTKD2	22868	broad.mit.edu	37	2	207634869	207634869	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:207634869G>C	ENST00000236980.6	+	3	1180	c.832G>C	c.(832-834)Gag>Cag	p.E278Q	FASTKD2_ENST00000402774.3_Missense_Mutation_p.E278Q|FASTKD2_ENST00000403094.3_Missense_Mutation_p.E278Q	NM_014929.3	NP_055744.2	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	278					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(2)	21				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		AACTGTTTTAGAGGCAATGGA	0.373000													8	48					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088062	86088062	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86088062C>G	ENST00000330753.4	+	2	971	c.204C>G	c.(202-204)ctC>ctG	p.L68L	FLRT2_ENST00000554746.1_Silent_p.L68L	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	68					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TAACTGTACTCTACCTCCACA	0.517000													66	49					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143039166	143039166	+	Missense_Mutation	SNP	C	C	G	rs143825889		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:143039166C>G	ENST00000343257.2	+	15	1814	c.1727C>G	c.(1726-1728)tCt>tGt	p.S576C		NM_000083.2	NP_000074	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	576					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CTGCAGCCCTCTCTCTATGAC	0.527000													36	47					0	0	1	0	0
GIT1	28964	broad.mit.edu	37	17	27909075	27909075	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:27909075C>T	ENST00000225394.3	-	5	741	c.493G>A	c.(493-495)Gag>Aag	p.E165K	GIT1_ENST00000394869.3_Missense_Mutation_p.E165K|GIT1_ENST00000581348.1_Missense_Mutation_p.E165K|GIT1_ENST00000579937.1_Missense_Mutation_p.E165K|RP11-68I3.2_ENST00000581474.1_RNA	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	165					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GTGCCCTTCTCTGGGTGGAAG	0.617000													36	29					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152462392	152462392	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:152462392C>G	ENST00000367255.5	-	139	25793	c.25192G>C	c.(25192-25194)Gag>Cag	p.E8398Q	SYNE1_ENST00000539504.1_Missense_Mutation_p.E553Q|SYNE1_ENST00000341594.5_Missense_Mutation_p.E8010Q|SYNE1_ENST00000356820.4_Missense_Mutation_p.E2922Q|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000354674.4_Missense_Mutation_p.E576Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.E8398Q|SYNE1_ENST00000448038.1_Missense_Mutation_p.E8350Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.E8350Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8398					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGCTCTCCTCTTCCTCCTTC	0.488000										HNSCC(10;0.0054)			58	16					0	0	1	0	0
LBR	3930	broad.mit.edu	37	1	225598067	225598067	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:225598067C>T	ENST00000338179.2	-	10	1365	c.1240G>A	c.(1240-1242)Gct>Act	p.A414T	LBR_ENST00000272163.4_Missense_Mutation_p.A414T	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	414					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity	p.A414T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		GATGGAACAGCGCGGTCCTGT	0.433000													16	69					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27059204	27059204	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:27059204C>T	ENST00000324856.7	+	4	2212	c.1841C>T	c.(1840-1842)tCa>tTa	p.S614L	ARID1A_ENST00000457599.2_Missense_Mutation_p.S614L|ARID1A_ENST00000374152.2_Missense_Mutation_p.S231L	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	614					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.S614L(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGGCATCCTCAGCCCCCTCA	0.478000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								17	30					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53967927	53967927	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:53967927G>C	ENST00000471389.1	+	8	1492	c.1270G>C	c.(1270-1272)Gag>Cag	p.E424Q	FTO_ENST00000394647.3_Missense_Mutation_p.E128Q|FTO_ENST00000463855.1_Missense_Mutation_p.E46Q|FTO_ENST00000431610.2_Missense_Mutation_p.E25Q|FTO_ENST00000460382.1_Missense_Mutation_p.E25Q	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	424					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						AGTTAAAAGAGAGGGGCTCCC	0.418000													12	25					0	0	1	0	0
DBP	1628	broad.mit.edu	37	19	49134232	49134232	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:49134232C>G	ENST00000222122.5	-	4	1283	c.840G>C	c.(838-840)gaG>gaC	p.E280D	DBP_ENST00000593500.1_Missense_Mutation_p.E78D|DBP_ENST00000599385.1_Missense_Mutation_p.E78D	NM_001352.3	NP_001343.2	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box) binding protein	280					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		ATATCTGGTTCTCCTTGAGCC	0.652000													24	33					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50733744	50733744	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:50733744C>G	ENST00000404971.1	-	14	3845	c.2506G>C	c.(2506-2508)Gag>Cag	p.E836Q	NRXN1_ENST00000402717.3_Missense_Mutation_p.E788Q|NRXN1_ENST00000401669.2_Missense_Mutation_p.E796Q|NRXN1_ENST00000406859.3_Missense_Mutation_p.E796Q|NRXN1_ENST00000405472.3_Missense_Mutation_p.E788Q|NRXN1_ENST00000406316.2_Missense_Mutation_p.E796Q|NRXN1_ENST00000331040.5_5'UTR	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	796	Laminin G-like 4.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.E837*(1)|p.E836*(1)|p.E796*(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAAGAGTCTCGGGACCTTTG	0.448000													9	19					0	0	1	0	0
LMNB2	84823	broad.mit.edu	37	19	2438516	2438516	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:2438516C>T	ENST00000325327.3	-	3	477	c.415G>A	c.(415-417)Gag>Aag	p.E139K	LMNB2_ENST00000582871.1_Missense_Mutation_p.E119K			Q03252	LMNB2_HUMAN	lamin B2	119	Coil 1B.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTCGCCCTCCCTCTTCTTG	0.662000													21	13					0	0	1	0	0
CAST	831	broad.mit.edu	37	5	96090429	96090429	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:96090429G>A	ENST00000395813.1	+	22	1880	c.1694G>A	c.(1693-1695)aGa>aAa	p.R565K	CAST_ENST00000508579.1_Missense_Mutation_p.R197K|CAST_ENST00000515663.1_Missense_Mutation_p.R205K|CAST_ENST00000509903.1_Missense_Mutation_p.R447K|CAST_ENST00000395812.2_Missense_Mutation_p.R524K|CAST_ENST00000309190.5_Missense_Mutation_p.R460K|CAST_ENST00000510756.1_Missense_Mutation_p.R543K|CAST_ENST00000508608.1_Missense_Mutation_p.R528K|CAST_ENST00000511049.1_Missense_Mutation_p.R468K|CAST_ENST00000338252.3_Missense_Mutation_p.R469K|CAST_ENST00000341926.3_Missense_Mutation_p.R482K|CAST_ENST00000511782.1_Missense_Mutation_p.R468K|CAST_ENST00000504465.1_Missense_Mutation_p.R410K|CAST_ENST00000348386.3_3'UTR|CAST_ENST00000508830.1_Missense_Mutation_p.R565K|CAST_ENST00000359176.4_Missense_Mutation_p.R546K|CAST_ENST00000325674.7_Missense_Mutation_p.R530K	NM_001284213.1	NP_001271142.1	P20810	ICAL_HUMAN	calpastatin	482							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		CCTGATTATAGATTAGAAGAG	0.348000													7	30					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41573838	41573838	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573838C>G	ENST00000263253.7	+	31	7342	c.6123C>G	c.(6121-6123)ctC>ctG	p.L2041L	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2041	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TCAGCCCACTCAAACCAGGCA	0.547000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				48	25					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186006603	186006603	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:186006603G>A	ENST00000265022.3	-	6	979	c.440C>T	c.(439-441)cCc>cTc	p.P147L	DGKG_ENST00000544847.1_Missense_Mutation_p.P147L|DGKG_ENST00000382164.4_Missense_Mutation_p.P147L|DGKG_ENST00000344484.4_Missense_Mutation_p.P147L	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	147					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCGAGGGACGGGGGGTTCCAG	0.547000													100	310					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47786794	47786794	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:47786794G>C	ENST00000359568.5	+	15	3012	c.2905G>C	c.(2905-2907)Gat>Cat	p.D969H	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	969					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTCCAGCCTTGATTCTTTGGA	0.562000													26	82					0	0	1	0	0
IFI44L	10964	broad.mit.edu	37	1	79107468	79107468	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:79107468G>A	ENST00000370751.5	+	9	1512	c.1333G>A	c.(1333-1335)Gag>Aag	p.E445K	IFI44L_ENST00000342282.3_Missense_Mutation_p.E187K|IFI44L_ENST00000476521.1_3'UTR	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like							cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						AGGTGCAATTGAGAGAGCGTT	0.448000													44	121					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19369602	19369602	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:19369602G>T	ENST00000291481.7	-	4	610	c.547C>A	c.(547-549)Cgc>Agc	p.R183S	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	183	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			GCGCACGCGCGCTGCGCCTCC	0.706000													11	18					1.02788e-11	1.07864e-11	1	1	0
TMEM248	55069	broad.mit.edu	37	7	66418353	66418353	+	Silent	SNP	G	G	A	rs149604295		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:66418353G>A	ENST00000341567.4	+	6	1176	c.921G>A	c.(919-921)gaG>gaA	p.E307E		NM_017994.4	NP_060464.1			transmembrane protein 248																		TTTGTCCCGAGAAGGTGAGCG	0.453000													35	180					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52865005	52865005	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:52865005G>T	ENST00000252250.6	-	5	1035	c.988C>A	c.(988-990)Ctg>Atg	p.L330M		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	330	Linker 12.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		ATGCTGTCCAGGTCCAGGTTG	0.562000													75	107					4.21487e-37	4.52068e-37	1	1	0
RASGEF1A	221002	broad.mit.edu	37	10	43696157	43696157	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:43696157G>A	ENST00000395809.1	-	5	3145	c.639C>T	c.(637-639)tgC>tgT	p.C213C	RASGEF1A_ENST00000395810.1_Silent_p.C213C|RASGEF1A_ENST00000374459.1_Silent_p.C221C|RASGEF1A_ENST00000472864.1_5'UTR			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	213					cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						CCAGGGGGTCGCAGCACACGC	0.642000													5	54					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76454708	76454708	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:76454708C>G	ENST00000389840.5	-	62	9998	c.9874G>C	c.(9874-9876)Gag>Cag	p.E3292Q	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.E3301Q					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTGATTTTCTCAGCTGTTGCT	0.522000													33	86					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56177626	56177626	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:56177626G>A	ENST00000399503.3	+	14	2599	c.2599G>A	c.(2599-2601)Gaa>Aaa	p.E867K		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	867					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GGAAATTGCCGAAGCCATCCA	0.478000													4	81					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35549207	35549207	+	Missense_Mutation	SNP	G	G	C	rs148729289	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:35549207G>C	ENST00000353139.5	-	37	4721	c.4240C>G	c.(4240-4242)Ctg>Gtg	p.L1414V	ACACA_ENST00000360679.3_Missense_Mutation_p.L1319V|ACACA_ENST00000335166.5_Missense_Mutation_p.L1299V|ACACA_ENST00000394406.2_Missense_Mutation_p.L1377V	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1377					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGGAAAGCCAGAGCAGGCTCC	0.443000													14	29					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	339064	339064	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:339064C>T	ENST00000432829.2	+	13	1593	c.1277C>T	c.(1276-1278)tCa>tTa	p.S426L	DOCK8_ENST00000453981.1_Missense_Mutation_p.S494L|DOCK8_ENST00000469391.1_Missense_Mutation_p.S426L	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	494	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TACAAAAGATCATCATCCTTA	0.398000													3	11					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78428504	78428504	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:78428504G>A	ENST00000370767.1	-	14	1382	c.1295C>T	c.(1294-1296)aCt>aTt	p.T432I	FUBP1_ENST00000370768.2_Missense_Mutation_p.T432I|FUBP1_ENST00000436586.2_Missense_Mutation_p.T453I			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	432	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						CTGTTGTGGAGTGCCACGAAT	0.368000			"""F, N"""		oligodendroglioma								3	30					0	0	1	0	0
GNPTG	84572	broad.mit.edu	37	16	1413046	1413046	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:1413046C>T	ENST00000204679.4	+	11	915	c.872C>T	c.(871-873)tCt>tTt	p.S291F		NM_032520.4	NP_115909.1	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphate transferase, gamma subunit	291						extracellular region|Golgi apparatus	protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	7		Hepatocellular(780;0.0893)				AGAGCCAAGTCTCCAGAGCAG	0.622000													11	19					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70530553	70530553	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:70530553C>T	ENST00000357887.3	-	3	2631	c.1878G>A	c.(1876-1878)atG>atA	p.M626I	SLC8A3_ENST00000528359.1_Missense_Mutation_p.M626I|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000381269.2_Intron|SLC8A3_ENST00000356921.2_Intron|SLC8A3_ENST00000216568.7_Intron|SLC8A3_ENST00000534137.1_Intron|SLC8A3_ENST00000533541.1_Intron	NM_033262.3	NP_150287.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	626					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCTGAAAACTCATATCCACCA	0.428000													32	27					0	0	1	0	0
C8orf76	84933	broad.mit.edu	37	8	124238796	124238796	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:124238796C>T	ENST00000276704.4	-	5	943	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K	ZHX1-C8ORF76_ENST00000357082.4_Missense_Mutation_p.E266K|C8orf76_ENST00000521310.1_5'UTR	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	298							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTTATCTTCAATTTCCTGC	0.418000													4	26					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93872	93872	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:93872T>G	ENST00000447903.2	-	4	559	c.244A>C	c.(244-246)Aag>Cag	p.K82Q	TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000332708.5_3'UTR|TUBB8_ENST00000309812.4_Missense_Mutation_p.K154Q			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	154					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TCCCGGATCTTACTGAGCAGA	0.602000													15	250					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201749566	201749566	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749566C>A	ENST00000367296.4	+	4	1664	c.1244C>A	c.(1243-1245)tCc>tAc	p.S415Y	NAV1_ENST00000367302.1_Missense_Mutation_p.S428Y|NAV1_ENST00000295624.6_Missense_Mutation_p.S415Y|NAV1_ENST00000367297.4_Missense_Mutation_p.S415Y|NAV1_ENST00000367295.1_Missense_Mutation_p.S24Y|NAV1_ENST00000367300.3_Missense_Mutation_p.S415Y|IPO9-AS1_ENST00000413035.1_RNA	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	415					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GAAAGCAGCTCCATCAGTAGT	0.463000													25	72					4.59853e-10	4.78134e-10	1	1	0
TSG101	7251	broad.mit.edu	37	11	18503374	18503374	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:18503374C>A	ENST00000536719.1	-	9	1020	c.886G>T	c.(886-888)Gaa>Taa	p.E296*	TSG101_ENST00000357193.3_Nonsense_Mutation_p.E191*|TSG101_ENST00000251968.3_Nonsense_Mutation_p.E296*			Q99816	TS101_HUMAN	tumor susceptibility 101	296					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						CTGAGTTCTTCATCCTTCTTT	0.358000													10	13					2.17888e-05	2.21802e-05	1	1	0
RASL12	51285	broad.mit.edu	37	15	65360144	65360144	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65360144C>G	ENST00000220062.4	-	1	306	c.30G>C	c.(28-30)gcG>gcC	p.A10A	RASL12_ENST00000434605.2_Intron|RASL12_ENST00000421977.3_Silent_p.A10A	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	10					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						GCCCGCTGCCCGCGCGGGGTT	0.766000													8	11					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110984713	110984713	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:110984713C>T	ENST00000524391.1	-	3	1797	c.765G>A	c.(763-765)ggG>ggA	p.G255G	KCNV1_ENST00000297404.1_Silent_p.G255G			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	255						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GGACAAACTCCCCGGTGAACC	0.522000													15	67					0	0	1	0	0
SSR2	6746	broad.mit.edu	37	1	155989830	155989830	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:155989830C>T	ENST00000295702.4	-	2	200	c.129G>A	c.(127-129)caG>caA	p.Q43Q	SSR2_ENST00000496742.1_Silent_p.Q43Q|SSR2_ENST00000480567.1_Silent_p.Q43Q|SSR2_ENST00000529008.1_Silent_p.Q43Q	NM_003145.3	NP_003136.1	P43308	SSRB_HUMAN	signal sequence receptor, beta (translocon-associated protein beta)	43					cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|stomach(1)	10	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGATGTTGTACTGCAAGGTCA	0.473000													8	65					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431442	140431442	+	Silent	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140431442T>C	ENST00000306549.3	+	1	464	c.387T>C	c.(385-387)aaT>aaC	p.N129N		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		129	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAATGACAATGCCCCAGTTT	0.542000													11	15					0	0	1	0	0
EEF2K	29904	broad.mit.edu	37	16	22291646	22291646	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:22291646G>A	ENST00000263026.5	+	17	2491	c.2017G>A	c.(2017-2019)Gag>Aag	p.E673K		NM_013302.3	NP_037434	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	673					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		CAGGGAGGCCGAGATGCTGTT	0.637000													28	18					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157914	65157914	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157914G>A	ENST00000323544.4	+	6	1428	c.1300G>A	c.(1300-1302)Gag>Aag	p.E434K	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	434										NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						GCTGGGCAGTGAGCCGGCCCC	0.602000													28	21					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76280741	76280741	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:76280741C>A	ENST00000263187.3	+	5	839	c.735C>A	c.(733-735)ttC>ttA	p.F245L		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	245					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						GGAAATACTTCAATGAAACAA	0.323000								Mismatch excision repair (MMR)					8	34					4.68919e-08	4.81669e-08	1	1	0
KCNK2	3776	broad.mit.edu	37	1	215259881	215259881	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:215259881C>G	ENST00000444842.2	+	2	367	c.217C>G	c.(217-219)Ctg>Gtg	p.L73V	KCNK2_ENST00000391894.2_Missense_Mutation_p.L58V|KCNK2_ENST00000391895.2_Missense_Mutation_p.L69V	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	73							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TGTCCTCTATCTGATCATCGG	0.483000													17	29					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802156	68802156	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:68802156G>C	ENST00000295569.7	-	4	636	c.144C>G	c.(142-144)atC>atG	p.I48M		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	48						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TCCCTTGCTTGATTTGGTGGT	0.493000													23	10					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121644785	121644785	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:121644785C>A	ENST00000395601.3	-	4	1309	c.895G>T	c.(895-897)Gac>Tac	p.D299Y	SNTB1_ENST00000517992.1_Missense_Mutation_p.D299Y|SNTB1_ENST00000519177.1_5'UTR	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	299					muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GTCAGCAGGTCATTAACGTTG	0.537000													24	67					3.73988e-18	3.96125e-18	1	1	0
KIRREL	55243	broad.mit.edu	37	1	158059548	158059548	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:158059548G>C	ENST00000368172.1	+	6	666	c.654G>C	c.(652-654)gtG>gtC	p.V218V	KIRREL_ENST00000392272.2_Silent_p.V301V|KIRREL_ENST00000368173.3_Silent_p.V420V|KIRREL_ENST00000360089.4_Silent_p.V240V|KIRREL_ENST00000359209.6_Silent_p.V404V|KIRREL_ENST00000416935.2_Silent_p.V304V			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	404						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					AGTATGCTGTGAGGGGTGACG	0.602000													38	211					0	0	1	0	0
STPG1	90529	broad.mit.edu	37	1	24706145	24706145	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:24706145T>A	ENST00000374409.1	-	5	714	c.460A>T	c.(460-462)Aat>Tat	p.N154Y	STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Missense_Mutation_p.N154Y|STPG1_ENST00000003583.8_Missense_Mutation_p.N107Y|STPG1_ENST00000440416.1_Missense_Mutation_p.N107Y	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		GTTCTTACATTGTAATAGTTT	0.373000													11	53					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128312003	128312003	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:128312003C>G	ENST00000368227.3	-	22	3424	c.3058G>C	c.(3058-3060)Gat>Cat	p.D1020H	PTPRK_ENST00000368213.5_Missense_Mutation_p.D1009H|PTPRK_ENST00000368226.4_Missense_Mutation_p.D1003H|PTPRK_ENST00000368215.3_Missense_Mutation_p.D1002H|PTPRK_ENST00000532331.1_Missense_Mutation_p.D1025H|PTPRK_ENST00000368207.3_Missense_Mutation_p.D1035H|PTPRK_ENST00000368210.3_Missense_Mutation_p.D1021H			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1002	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ACTTCAGTATCATCAGGCCAA	0.348000													12	47					0	0	1	0	0
GNAL	2774	broad.mit.edu	37	18	11868562	11868562	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:11868562G>A	ENST00000334049.6	+	9	1539	c.931G>A	c.(931-933)Gtc>Atc	p.V311I	GNAL_ENST00000423027.3_Missense_Mutation_p.V234I|GNAL_ENST00000602628.1_Missense_Mutation_p.V27I|GNAL_ENST00000269162.5_Missense_Mutation_p.V234I|GNAL_ENST00000535121.1_Missense_Mutation_p.V234I	NM_182978.3	NP_892023.1	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	234					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)	12						TATCATTTACGTCGCAGCCTG	0.463000													33	79					0	0	1	0	0
OSER1	51526	broad.mit.edu	37	20	42825950	42825950	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:42825950C>T	ENST00000372970.2	-	6	801	c.621G>A	c.(619-621)aaG>aaA	p.K207K	OSER1_ENST00000255174.2_Silent_p.K207K					oxidative stress responsive serine-rich 1																		CATGCCATCTCTTACACTGGC	0.488000													23	60					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240255687	240255687	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:240255687C>T	ENST00000319653.9	+	1	508	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	93					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCGGCGGCTCCCGCGAAGAT	0.622000													9	27					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58846394	58846394	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:58846394C>G	ENST00000329665.4	+	2	373	c.226C>G	c.(226-228)Cag>Gag	p.Q76E		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	76	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GCTGTGCTGTCAGTGGCTGCA	0.657000													11	128					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45389939	45389939	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:45389939C>T	ENST00000389039.6	-	28	3951	c.3566G>A	c.(3565-3567)gGt>gAt	p.G1189D	DUOX2_ENST00000603300.1_Splice_Site_p.G1189D			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1189	Ferric oxidoreductase.|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ACCTGTCATACCTGGGGGCAG	0.587000													16	55					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G|EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													5	96					0	0	1	0	0
KIAA1841	84542	broad.mit.edu	37	2	61333734	61333734	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:61333734A>G	ENST00000402291.1	+	14	1789	c.1548A>G	c.(1546-1548)atA>atG	p.I516M	KIAA1841_ENST00000356719.2_Missense_Mutation_p.I516M|KIAA1841_ENST00000453873.1_Missense_Mutation_p.I516M|KIAA1841_ENST00000295031.5_Missense_Mutation_p.I516M	NM_001129993.1	NP_001123465.1	Q6NSI8	K1841_HUMAN	KIAA1841	516										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			AAAAGGGTATAGAATGTGATG	0.348000													18	45					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78293102	78293102	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:78293102C>G	ENST00000582970.1	+	17	3157	c.3014C>G	c.(3013-3015)tCa>tGa	p.S1005*	RNF213_ENST00000508628.2_Nonsense_Mutation_p.S1054*|RNF213_ENST00000456466.1_Nonsense_Mutation_p.S1005*|RNF213_ENST00000319921.4_Nonsense_Mutation_p.S1005*	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	1005										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCCGTGAGCTCAGCCTGCCAG	0.547000													44	32					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28926024	28926024	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:28926024G>C	ENST00000257192.4	+	14	2175	c.1963G>C	c.(1963-1965)Gaa>Caa	p.E655Q	DSG1_ENST00000462981.2_Missense_Mutation_p.E14Q|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578119.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	655					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GACAGGATTTGAACTAACAGA	0.368000													7	28					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2024268	2024268	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:2024268G>A	ENST00000568546.1	+	3	292	c.164G>A	c.(163-165)gGg>gAg	p.G55E		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	55					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						GTGGCCTCGGGGGCCGTGCTG	0.647000													38	83					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:90161926T>C	ENST00000567960.1	+	0	662				TUBB8P7_ENST00000564451.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													4	44					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131745215	131745215	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:131745215C>T	ENST00000372577.2	+	17	1725	c.1704C>T	c.(1702-1704)atC>atT	p.I568I		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	568					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						TCAAACCCATCATTGATCTCG	0.502000													40	52					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650720	90650720	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650720C>G	ENST00000282146.4	+	2	1041	c.600C>G	c.(598-600)atC>atG	p.I200M		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	200						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				TCATGCTGATCCTATGCACAG	0.592000													32	162					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187627410	187627410	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:187627410G>A	ENST00000304698.5	+	8	2544	c.2341G>A	c.(2341-2343)Gga>Aga	p.G781R		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	781						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AGAGTCGCCAGGAAGGAAAAG	0.502000													3	18					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1523488	1523488	+	Splice_Site	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:1523488G>A	ENST00000389470.4	-	27	3916	c.3917C>T	c.(3916-3918)tCg>tTg	p.S1306L	INTS1_ENST00000404767.3_Splice_Site_p.S1144L			Q8N201	INT1_HUMAN	integrator complex subunit 1	1144					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTGAGACTCCGACTGTGGGAA	0.647000													17	78					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21224807	21224807	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:21224807C>G	ENST00000233242.1	-	29	13614	c.13487G>C	c.(13486-13488)aGa>aCa	p.R4496T		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	4496					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGTTTATATCTAAACTGCTG	0.363000													11	38					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66457999	66457999	+	RNA	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:66457999C>A	ENST00000424345.1	+	0	67																											ATGCTGCTGCCTGGCGGTGCT	0.731000													4	21					1.23904e-05	1.26509e-05	1	1	0
OR52W1	120787	broad.mit.edu	37	11	6220474	6220474	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:6220474C>G	ENST00000311352.2	+	1	99	c.21C>G	c.(19-21)ctC>ctG	p.L7L		NM_001005178.1	NP_001005178.1	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W, member 1	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)	11		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTACAACTCAATTCCACCT	0.517000													34	43					0	0	1	0	0
ASCL1	429	broad.mit.edu	37	12	103352354	103352354	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:103352354G>T	ENST00000266744.3	+	1	891	c.332G>T	c.(331-333)aGc>aTc	p.S111I		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	111					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						TTTGGCTACAGCCTGCCGCAG	0.662000													15	9					7.07596e-05	7.18157e-05	1	1	0
ADAM29	11086	broad.mit.edu	37	4	175896737	175896737	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:175896737C>A	ENST00000359240.3	+	5	731	c.61C>A	c.(61-63)Cag>Aag	p.Q21K	ADAM29_ENST00000514159.1_Missense_Mutation_p.Q21K|ADAM29_ENST00000404450.4_Missense_Mutation_p.Q21K|ADAM29_ENST00000445694.1_Missense_Mutation_p.Q21K	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	21					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGGACACATCCAGGATGAGCA	0.507000													20	75					1.96895e-08	2.02861e-08	1	1	0
WDR76	79968	broad.mit.edu	37	15	44149340	44149340	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:44149340A>G	ENST00000263795.6	+	10	1458	c.1388A>G	c.(1387-1389)tAt>tGt	p.Y463C	WDR76_ENST00000381246.2_Missense_Mutation_p.Y399C	NM_001167941.1|NM_024908.3	NP_001161413.1|NP_079184.2	Q9H967	WDR76_HUMAN	WD repeat domain 76	463										breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)	20		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		CATAGACAGTATTTTATCACT	0.373000													12	16					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62330234	62330234	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:62330234C>G	ENST00000371158.2	+	20	2878	c.2764C>G	c.(2764-2766)Caa>Gaa	p.Q922E	INADL_ENST00000316485.6_Missense_Mutation_p.Q922E	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	922					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						ATCCGAGTCTCAAGAGGCAAG	0.483000													58	54					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67685194	67685194	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:67685194C>T	ENST00000334583.6	+	23	2617	c.2289C>T	c.(2287-2289)atC>atT	p.I763I	RLTPR_ENST00000545661.1_Silent_p.I727I	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	763										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		AGGATGCCATCCAAAATGCCA	0.587000													42	86					0	0	1	0	0
COPS6	10980	broad.mit.edu	37	7	99686983	99686983	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:99686983C>G	ENST00000303904.3	+	2	184	c.147C>G	c.(145-147)ctC>ctG	p.L49L	COPS6_ENST00000418625.1_Silent_p.L48L	NM_006833.4	NP_006824.2	Q7L5N1	CSN6_HUMAN	COP9 signalosome subunit 6	49	MPN.				cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|stomach(1)	12	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTGTCATTCTCAACATCTCAG	0.592000													134	175					0	0	1	0	0
ESD	2098	broad.mit.edu	37	13	47365491	47365491	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:47365491C>T	ENST00000378720.3	-	3	240	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	ESD_ENST00000378697.1_5'UTR|ESD_ENST00000495654.1_5'UTR	NM_001984.1	NP_001975.1	P10768	ESTD_HUMAN	esterase D	20						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	9		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	CTGTCATGTTCAAAAACTTTC	0.303000													13	12					0	0	1	0	0
RHOQ	23433	broad.mit.edu	37	2	46770291	46770291	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:46770291G>A	ENST00000238738.4	+	1	425	c.106G>A	c.(106-108)Gag>Aag	p.E36K	RHOQ_ENST00000465198.1_Intron	NM_012249.3	NP_036381.2	P17081	RHOQ_HUMAN	ras homolog family member Q	36					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGCCTTCCCGGAGGAGTACGT	0.652000													51	172					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142490016	142490016	+	RNA	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:142490016C>G	ENST00000430863.1	-	0	1049					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TCACCTCCCTCTGCTTGGGCC	0.592000													12	48					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54932494	54932494	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:54932494G>A	ENST00000301194.4	+	3	471	c.349G>A	c.(349-351)Gat>Aat	p.D117N	TTYH1_ENST00000391739.3_Missense_Mutation_p.D166N|TTYH1_ENST00000376531.3_Missense_Mutation_p.D117N|TTYH1_ENST00000376530.3_Missense_Mutation_p.D117N			Q9H313	TTYH1_HUMAN	tweety family member 1	117					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TGAGACCAGTGATGGGGTGTC	0.637000													36	164					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235943684	235943684	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:235943684G>A	ENST00000409212.1	+	3	545	c.38G>A	c.(37-39)gGc>gAc	p.G13D	SH3BP4_ENST00000344528.4_Missense_Mutation_p.G13D|SH3BP4_ENST00000392011.2_Missense_Mutation_p.G13D			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	13					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AACTCCAATGGCCTCCCTCGC	0.552000													5	30					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31478699	31478699	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:31478699C>T	ENST00000373747.3	-	5	820		c.e5+1		PUM1_ENST00000257075.5_Splice_Site|PUM1_ENST00000373742.2_Intron|PUM1_ENST00000423018.2_Intron|PUM1_ENST00000373741.4_Splice_Site|PUM1_ENST00000424085.2_Intron|PUM1_ENST00000440538.2_Splice_Site|PUM1_ENST00000426105.2_Splice_Site	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1						cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AGCCAACTTACAAATCCTCCT	0.478000													33	24					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137928489	137928489	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:137928489C>T	ENST00000409968.1	+	7	1882	c.1704C>T	c.(1702-1704)gcC>gcT	p.A568A	THSD7B_ENST00000413152.2_Silent_p.A537A|THSD7B_ENST00000272643.3_Silent_p.A568A|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTCTGAAGGCCGTCTGCCAGA	0.483000													11	12					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78477333	78477333	+	Silent	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:78477333T>C	ENST00000377211.4	-	4	1181	c.1029A>G	c.(1027-1029)cgA>cgG	p.R343R	EDNRB_ENST00000446573.1_Silent_p.R253R|EDNRB_ENST00000334286.5_Silent_p.R253R	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	253					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GCAAGCAGATTCGCAGATAAC	0.373000													23	34					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42112115	42112115	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:42112115T>C	ENST00000401548.3	+	5	534	c.494T>C	c.(493-495)aTc>aCc	p.I165T	MEI1_ENST00000540833.1_5'UTR|MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	165							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GTGGATGCCATCCCTGCTCTG	0.532000													14	32					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83218237	83218237	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:83218237C>G	ENST00000563800.1	-	9	3178	c.1453G>C	c.(1453-1455)Gac>Cac	p.D485H	CPEB1_ENST00000450751.2_Missense_Mutation_p.D383H|CPEB1_ENST00000562019.1_Missense_Mutation_p.D463H|CPEB1_ENST00000564522.1_Missense_Mutation_p.D383H|RP11-152F13.10_ENST00000562833.1_Missense_Mutation_p.L192F|CPEB1_ENST00000398591.2_Missense_Mutation_p.D388H|CPEB1_ENST00000261723.6_Missense_Mutation_p.D461H|CPEB1_ENST00000568757.1_Missense_Mutation_p.D383H|CPEB1_ENST00000568128.1_Missense_Mutation_p.D458H|CPEB1_ENST00000423133.2_Missense_Mutation_p.D383H|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000398592.2_Missense_Mutation_p.D232H			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	463	Necessary for stress granule assembly and correct localization in dcp1 bodies.|RRM 2.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			TTATCTGTGTCAATCCCGGCA	0.517000													16	41					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235973651	235973651	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:235973651C>G	ENST00000389794.3	-	5	641	c.467G>C	c.(466-468)aGa>aCa	p.R156T	LYST_ENST00000389793.2_Missense_Mutation_p.R156T|LYST_ENST00000536965.1_Missense_Mutation_p.R156T			Q99698	LYST_HUMAN	lysosomal trafficking regulator	156					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTTGCATCTCTTACAGAATA	0.418000													30	42					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59925298	59925298	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:59925298G>C	ENST00000256858.6	+	14	2262	c.2014G>C	c.(2014-2016)Gat>Cat	p.D672H	KIAA1468_ENST00000398130.2_Missense_Mutation_p.D672H			Q9P260	K1468_HUMAN	KIAA1468	672							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				GGGATACATTGATGATCCAGA	0.313000													5	16					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75190679	75190679	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:75190679C>G	ENST00000336926.6	-	13	1171	c.1145G>C	c.(1144-1146)aGa>aCa	p.R382T	HIP1_ENST00000434438.2_Missense_Mutation_p.R382T	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	382					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						ACTGATCTCTCTGTATAGTCG	0.443000			T	PDGFRB	CMML								46	85					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798381	140798381	+	Missense_Mutation	SNP	A	A	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140798381A>T	ENST00000398594.2	+	1	955	c.955A>T	c.(955-957)Ata>Tta	p.I319L	PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB4_ENST00000519479.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACGATAAACATAGAAGCAAA	0.398000													7	1					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	124177235	124177235	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:124177235G>A	ENST00000274008.4	+	15	2474	c.2405G>A	c.(2404-2406)aGa>aAa	p.R802K		NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5						cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						GCAGCAACAAGAAGGGAAATA	0.438000													42	15					0	0	1	0	0
SCFD1	23256	broad.mit.edu	37	14	31169416	31169416	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:31169416G>C	ENST00000458591.2	+	16	1589	c.1362G>C	c.(1360-1362)atG>atC	p.M454I	SCFD1_ENST00000544052.2_Missense_Mutation_p.M387I|SCFD1_ENST00000421551.3_Missense_Mutation_p.M395I|SCFD1_ENST00000541123.1_Missense_Mutation_p.M269I|SCFD1_ENST00000396629.2_Missense_Mutation_p.M362I|SCFD1_ENST00000554486.1_3'UTR	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	454					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AAGATAAAATGAGGTTGTTTC	0.348000													20	37					0	0	1	0	0
CDCA3	83461	broad.mit.edu	37	12	6959647	6959647	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:6959647C>T	ENST00000422785.3	-	3	338	c.234G>A	c.(232-234)atG>atA	p.M78I	CDCA3_ENST00000540683.1_Missense_Mutation_p.M78I|CDCA3_ENST00000535406.1_Missense_Mutation_p.M78I|CDCA3_ENST00000229265.6_Missense_Mutation_p.M78I|CDCA3_ENST00000538862.2_Missense_Mutation_p.M78I			Q99618	CDCA3_HUMAN	cell division cycle associated 3	78					cell division|mitosis	cytosol				breast(1)|endometrium(1)|large_intestine(4)|lung(1)|stomach(1)	8						TGCTGGTCTTCATAGGTGTCC	0.542000													96	117					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42088479	42088479	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:42088479G>C	ENST00000244020.3	+	3	431	c.325G>C	c.(325-327)Gaa>Caa	p.E109Q		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	109					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						TGTTCGTACAGAATACAGGCT	0.398000													45	66					0	0	1	0	0
RFX1	5989	broad.mit.edu	37	19	14076445	14076445	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:14076445G>A	ENST00000254325.4	-	15	2340	c.2106C>T	c.(2104-2106)ccC>ccT	p.P702P		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	702					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CACTGGGGATGGGCCGCAGCA	0.652000													12	43					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56734667	56734667	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:56734667G>C	ENST00000381295.2	+	5	929	c.581G>C	c.(580-582)aGa>aCa	p.R194T	EXOC1_ENST00000346134.7_Missense_Mutation_p.R194T|EXOC1_ENST00000349598.6_Missense_Mutation_p.R194T	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	194					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					AAATTGTCCAGAGAGCTGCAG	0.388000													9	49					0	0	1	0	0
CRIP3	401262	broad.mit.edu	37	6	43273792	43273792	+	Missense_Mutation	SNP	T	T	C	rs139840752	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:43273792T>C	ENST00000274990.4	-	7	570	c.566A>G	c.(565-567)cAt>cGt	p.H189R	CRIP3_ENST00000372569.3_Intron			Q6Q6R5	CRIP3_HUMAN	cysteine-rich protein 3	189						cytoplasm	zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GTGTCTGGGATGGGGCTGCCC	0.557000													119	27					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43802184	43802184	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:43802184G>C	ENST00000291532.3	-	9	1897	c.942C>G	c.(940-942)ctC>ctG	p.L314L	TMPRSS3_ENST00000398397.3_Silent_p.L314L|TMPRSS3_ENST00000398405.1_Silent_p.L312L|TMPRSS3_ENST00000433957.2_Silent_p.L314L|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000380399.1_Silent_p.L398L	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	314	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						CATTGAACGTGAGTGGCCCGG	0.498000													36	44					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48634393	48634393	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:48634393G>A	ENST00000263274.7	-	19	2180	c.1761C>T	c.(1759-1761)ttC>ttT	p.F587F	LIG1_ENST00000536218.1_Silent_p.F519F|LIG1_ENST00000427526.2_Silent_p.F556F	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	587					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GATTCCTGCTGAAGATCTTCA	0.577000								Nucleotide excision repair (NER)					7	117					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895017	90895017	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:90895017C>T	ENST00000287934.2	+	1	1235	c.822C>T	c.(820-822)ttC>ttT	p.F274F		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	274					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GAGGCAAGTTCTCCTGCCCGC	0.692000													11	8					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21102872	21102872	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:21102872G>C	ENST00000377122.4	-	23	2738	c.2342C>G	c.(2341-2343)tCa>tGa	p.S781*	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	781					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CCCTACCATTGAAATATGATT	0.383000													9	29					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90078972	90078972	+	Silent	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:90078972A>G	ENST00000405460.2	+	66	13359	c.13263A>G	c.(13261-13263)ccA>ccG	p.P4421P	GPR98_ENST00000425867.2_Silent_p.P82P	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4421					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCATGATCCCAGTGGTGAGGC	0.448000													43	168					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862967	10862967	+	RNA	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:10862967C>A	ENST00000559480.1	+	0	263																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GCCAGAGTCACCATAACCAGG	0.527000													63	397					1.51283e-56	1.63289e-56	1	1	0
ZNF550	162972	broad.mit.edu	37	19	58058953	58058953	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:58058953C>T	ENST00000325134.5	-	3	719	c.563G>A	c.(562-564)cGa>cAa	p.R188Q	ZNF550_ENST00000457177.1_Missense_Mutation_p.R220Q|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000594943.1_Intron|ZNF550_ENST00000506609.2_Missense_Mutation_p.R179Q			Q7Z398	ZN550_HUMAN	zinc finger protein 550	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	7		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCTCTGATGTCGAACGAGATA	0.483000													42	65					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78031766	78031766	+	Splice_Site	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:78031766C>G	ENST00000370801.3	-	14	3042	c.2567G>C	c.(2566-2568)tGt>tCt	p.C856S	ZZZ3_ENST00000476275.1_5'UTR|ZZZ3_ENST00000370798.1_Splice_Site_p.C362S	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	856					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						AAACACTTACCAGTCTGAACA	0.393000													4	15					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41365655	41365655	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:41365655C>T	ENST00000361937.3	-	11	1790	c.1366G>A	c.(1366-1368)Gaa>Aaa	p.E456K	INO80_ENST00000401393.3_Missense_Mutation_p.E456K			Q9ULG1	INO80_HUMAN	INO80 complex subunit	456	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TAAGCATTTTCAGCATTCTTC	0.378000													6	49					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:7578454G>A	ENST00000420246.2	-	5	608	c.476C>T	c.(475-477)gCc>gTc	p.A159V	TP53_ENST00000413465.2_Missense_Mutation_p.A159V|TP53_ENST00000455263.2_Missense_Mutation_p.A159V|TP53_ENST00000269305.4_Missense_Mutation_p.A159V|TP53_ENST00000445888.2_Missense_Mutation_p.A159V|TP53_ENST00000359597.4_Missense_Mutation_p.A159V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	159	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		A -> D (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(33)|p.0?(8)|p.A159D(7)|p.R158fs(6)|p.R65fs(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R26fs(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.R158fs*11(1)|p.A66V(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.A27V(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			63	19					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77043906	77043906	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:77043906C>T	ENST00000339142.2	+	5	1137	c.582C>T	c.(580-582)ttC>ttT	p.F194F	C1QTNF1_ENST00000311661.4_Silent_p.F112F|C1QTNF1_ENST00000578229.1_Silent_p.F112F|C1QTNF1_ENST00000580474.1_Silent_p.F194F|C1QTNF1_ENST00000354124.3_Silent_p.F204F|C1QTNF1_ENST00000392445.2_Silent_p.F194F|C1QTNF1_ENST00000583904.1_Silent_p.F194F|C1QTNF1_ENST00000580454.1_Silent_p.F194F|C1QTNF1_ENST00000581774.1_Silent_p.F194F|C1QTNF1_ENST00000582625.1_3'UTR|C1QTNF1_ENST00000579760.1_Silent_p.F194F	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	194	C1q.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GCCTCTACTTCTTCAGCCTCA	0.552000													82	69					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22955190	22955190	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:22955190C>A	ENST00000313077.7	+	15	1709	c.1584C>A	c.(1582-1584)ttC>ttA	p.F528L	CYFIP1_ENST00000560848.1_Missense_Mutation_p.F528L	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	528					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ATGAGCCCTTCAATGACCCAG	0.622000													33	49					4.44401e-20	4.73656e-20	1	1	0
SNX27	81609	broad.mit.edu	37	1	151584734	151584735	+	In_Frame_Ins	INS	-	-	GGC			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:151584734_151584735insGGC	ENST00000368843.3	+	1	177_178	c.57_58insGGC	c.(58-60)ggc>GGCggc	p.20_20G>GG	SNX27_ENST00000458013.2_In_Frame_Ins_p.20_20G>GG|RP11-404E16.1_ENST00000504583.2_RNA	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	20					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAcggaggtggcggcggcgg	0.738													10	19	---	---	---	---					
BTG2	7832	broad.mit.edu	37	1	203276381	203276382	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:203276381_203276382delAG	ENST00000290551.4	+	2	363_364	c.292_293delAG	c.(292-294)agcfs	p.S98fs		NM_006763.2	NP_006754.1	P78543	BTG2_HUMAN	BTG family, member 2	98					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(75;0.203)			GCTGCTGCCCAGCGAGCTGACC	0.644													34	93	---	---	---	---					
PGM5P3-AS1	101929127	broad.mit.edu	37	2	114298850	114298851	+	RNA	DEL	AC	AC	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:114298850_114298851delAC	ENST00000446595.1	-	0	90																											GGGTacacagacacacacacac	0.564													2	4	---	---	---	---					
NGEF	25791	broad.mit.edu	37	2	233792653	233792653	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:233792653delG	ENST00000373552.4	-	1	211	c.57delC	c.(55-57)tccfs	p.S19fs	NGEF_ENST00000409079.1_Frame_Shift_Del_p.S19fs|NGEF_ENST00000264051.3_Intron	NM_001114090.1	NP_001107562.1	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	0	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TTTCCGAGGTGGAACTGTCGT	0.796													2	4	---	---	---	---					
AC128709.2	0	broad.mit.edu	37	3	197186538	197186539	+	RNA	INS	-	-	G	rs111705519		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:197186538_197186539insG	ENST00000420213.1	+	0	138																											TGTGGTCGGGAGGGATGCAGTT	0.589													12	91	---	---	---	---					
AACSP1	729522	broad.mit.edu	37	5	178210405	178210406	+	RNA	DEL	CA	CA	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:178210405_178210406delCA	ENST00000503486.2	-	0	647					NR_024035.1																						caccacacaccacacacacaca	0.515													4	3	---	---	---	---					
FOXC1	2296	broad.mit.edu	37	6	1611802	1611803	+	In_Frame_Ins	INS	-	-	GGC	rs76840944		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:1611802_1611803insGGC	ENST00000380874.2	+	1	1122_1123	c.1122_1123insGGC	c.(1123-1125)ggc>GGCggc	p.375_375G>GG		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	375	Poly-Gly.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		cgggcagctcgggcggcggcgg	0.797													4	5	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	65066594	65066595	+	RNA	INS	-	-	TG	rs34200535	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:65066594_65066595insTG	ENST00000524360.1	-	0	128				RP11-32K4.1_ENST00000523191.1_RNA|RP11-32K4.1_ENST00000520365.1_RNA|RP11-32K4.1_ENST00000521958.1_RNA																							CCCTCCAACAAtgtgtgtgtgt	0.396													6	4	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68406889	68406889	+	RNA	DEL	G	G	-	rs141841413	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:68406889delG	ENST00000417843.2	-	0	224																											atccagggcagtcatagtggt	0.498													8	10	---	---	---	---					
PPFIA1	8500	broad.mit.edu	37	11	70194407	70194407	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:70194407delC	ENST00000253925.7	+	16	2259	c.2044delC	c.(2044-2046)cccfs	p.P683fs	PPFIA1_ENST00000389547.3_Frame_Shift_Del_p.P683fs|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	683					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GAGCTCCATTCCCCCCTACCC	0.557													8	2893	---	---	---	---					
TBC1D30	23329	broad.mit.edu	37	12	65269038	65269038	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:65269038delG	ENST00000542120.1	+	13	1659	c.1414delG	c.(1414-1416)gggfs	p.G472fs	TBC1D30_ENST00000539867.1_Frame_Shift_Del_p.G586fs|TBC1D30_ENST00000229088.6_Frame_Shift_Del_p.G749fs			F5GYJ9	F5GYJ9_HUMAN	TBC1 domain family, member 30	586						intracellular	Rab GTPase activator activity			NS(3)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	5						TCCGGGCTGTGGGGACACCGT	0.577													2	4	---	---	---	---					
LINC01257	116437	broad.mit.edu	37	12	131687287	131687287	+	RNA	DEL	G	G	-	rs7486559	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:131687287delG	ENST00000376678.2	+	0	220					NR_026670.2																						CCTCCTCCCCGCGACGTGACG	0.632													2	4	---	---	---	---					
RP11-624L4.1	0	broad.mit.edu	37	15	39433239	39433240	+	RNA	DEL	AC	AC	-	rs5812083		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:39433239_39433240delAC	ENST00000561058.1	-	0	44				RP11-624L4.1_ENST00000558209.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA																							TTTcacacatacacacacacac	0.421													4	6	---	---	---	---					
LOC101928188	101928188	broad.mit.edu	37	16	29231001	29231002	+	RNA	DEL	AT	AT	-	rs10565454		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:29231001_29231002delAT	ENST00000566070.1	-	0	350_351																											acgcatacacatgtgcccagac	0.480													4	5	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58926335	58926336	+	RNA	INS	-	-	C	rs113534201	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:58926335_58926336insC	ENST00000500117.1	+	0	679																											caccaccatcacccccactact	0.535													4	7	---	---	---	---					
LA16c-444G7.1	0	broad.mit.edu	37	16	88278000	88278003	+	RNA	DEL	TGGA	TGGA	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:88278000_88278003delTGGA	ENST00000563190.1	+	0	119																											aatgcatgggtggatggatggatg	0.529													5	5	---	---	---	---					
SLFN12L	100506736	broad.mit.edu	37	17	33806620	33806620	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:33806620delA	ENST00000260908.7	-	2	726	c.609delT	c.(607-609)tttfs	p.F203fs	SLFN12L_ENST00000449046.1_Frame_Shift_Del_p.F234fs|SLFN12L_ENST00000361112.4_Frame_Shift_Del_p.F232fs	NM_001195790.1	NP_001182719.1	Q6IEE8	SN12L_HUMAN	schlafen family member 12-like	235						integral to membrane	ATP binding	p.N235fs*1(4)		breast(1)|endometrium(4)|kidney(5)|large_intestine(2)|lung(3)|ovary(1)	16						CTGTTCTGTTAAAAAAATCAG	0.368													2	4	---	---	---	---					
LINC00854	100874261	broad.mit.edu	37	17	41381913	41381914	+	RNA	INS	-	-	T	rs11403368		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:41381913_41381914insT	ENST00000433702.2	-	0	14				LINC00854_ENST00000608223.1_RNA	NR_047479.1																						accctgatctatcatcgggagg	0.550													12	63	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	111052	111052	+	RNA	DEL	C	C	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:111052delC	ENST00000608049.1	+	0	389					NR_033770.1																						ctaggttcagcctacaggagc	0.488													8	37	---	---	---	---					
LPPR2	64748	broad.mit.edu	37	19	11473280	11473288	+	In_Frame_Del	DEL	GCGTGGTCC	GCGTGGTCC	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:11473280_11473288delGCGTGGTCC	ENST00000251473.5	+	7	1131_1139	c.755_763delGCGTGGTCC	c.(754-765)ggcgtggtccgc>ggc	p.VVR253del	DKFZP761J1410_ENST00000591608.1_In_Frame_Del_p.VVR228del	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					TTCCTGGTGGGCGTGGTCCGCGTGGCCGA	0.651													22	137	---	---	---	---					
LOC284395	284395	broad.mit.edu	37	19	29930019	29930020	+	RNA	DEL	GA	GA	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:29930019_29930020delGA	ENST00000582581.1	-	0	329					NR_040029.1																						gggagggagggagagagagagg	0.644													4	9	---	---	---	---					
LILRB1	10859	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:55146148_55146150delCTC	ENST00000396331.1	+	11	1774_1776	c.1417_1419delCTC	c.(1417-1419)ctcdel	p.L479del	LILRB1_ENST00000418536.2_In_Frame_Del_p.L463del|LILRB1_ENST00000324602.7_In_Frame_Del_p.L480del|LILRB1_ENST00000396321.2_In_Frame_Del_p.L479del|LILRB1_ENST00000396315.1_In_Frame_Del_p.L480del|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000396332.4_In_Frame_Del_p.L479del|LILRB1_ENST00000396317.1_In_Frame_Del_p.L463del|LILRB1_ENST00000427581.2_In_Frame_Del_p.L529del|LILRB1_ENST00000434867.2_In_Frame_Del_p.L479del|LILRB1_ENST00000448689.1_In_Frame_Del_p.L479del|LILRB1_ENST00000396327.3_In_Frame_Del_p.L480del	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	479					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.581										HNSCC(37;0.09)			9	80	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11058882	11058882	+	RNA	DEL	A	A	-	rs145149071		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:11058882delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATGTGGGGGAAAAAAATTAG	0.358													6	2	---	---	---	---