Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SYNE1	23345	broad.mit.edu	37	6	152675920	152675920	+	Silent	SNP	C	C	T	rs114858512	byFrequency	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:152675920C>T	ENST00000367255.5	-	67	11401	c.10800G>A	c.(10798-10800)ttG>ttA	p.L3600L	SYNE1_ENST00000423061.1_Silent_p.L3607L|SYNE1_ENST00000341594.5_Silent_p.L3571L|SYNE1_ENST00000265368.4_Silent_p.L3600L|SYNE1_ENST00000448038.1_Silent_p.L3607L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3600					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCATTAGCCTCAATTTGTTCA	0.502000										HNSCC(10;0.0054)			17	60					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058669	152058669	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:152058669C>G	ENST00000368806.1	-	3	1553	c.1489G>C	c.(1489-1491)Gaa>Caa	p.E497Q		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	497							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGTGTTCTTTCTCTTGCCCCC	0.478000													33	168					0	0	1	0	0
STXBP5	134957	broad.mit.edu	37	6	147527160	147527160	+	Silent	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:147527160A>G	ENST00000367481.3	+	2	312	c.204A>G	c.(202-204)gtA>gtG	p.V68V	STXBP5_ENST00000321680.6_Silent_p.V68V|STXBP5_ENST00000367480.3_Silent_p.V68V|STXBP5_ENST00000179882.6_5'UTR|STXBP5_ENST00000546097.1_Silent_p.V68V	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	68					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTGATCCTGTACAGAAGATCC	0.463000													35	25					0	0	1	0	0
TRIM68	55128	broad.mit.edu	37	11	4621770	4621770	+	Silent	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:4621770C>G	ENST00000300747.5	-	7	1483	c.1194G>C	c.(1192-1194)ctG>ctC	p.L398L		NM_018073.6	NP_060543.5	Q6AZZ1	TRI68_HUMAN	tripartite motif containing 68	398	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding	p.L398L(1)		breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTCCCTTCCTCAGCCTTATCA	0.557000													12	41					0	0	1	0	0
PAIP1	10605	broad.mit.edu	37	5	43556029	43556029	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr5:43556029A>T	ENST00000306846.3	-	2	570	c.338T>A	c.(337-339)aTg>aAg	p.M113K	PAIP1_ENST00000436644.2_Missense_Mutation_p.M34K|PAIP1_ENST00000338972.4_Start_Codon_SNP_p.M1K|PAIP1_ENST00000514514.1_Missense_Mutation_p.M34K	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	113					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					GGGCTTAGCCATTGCTGACTC	0.473000													62	60					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121481797	121481797	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:121481797C>T	ENST00000260197.7	+	39	5381	c.5252C>T	c.(5251-5253)cCa>cTa	p.P1751L	SORL1_ENST00000534286.1_Missense_Mutation_p.P661L|SORL1_ENST00000532694.1_Missense_Mutation_p.P597L|SORL1_ENST00000527934.1_Missense_Mutation_p.P366L|SORL1_ENST00000525532.1_Missense_Mutation_p.P695L	NM_003105.5	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1751	Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ATCCCACCACCAGATATCCAC	0.418000													29	55					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48623808	48623808	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:48623808C>G	ENST00000328333.8	-	26	3614	c.3507G>C	c.(3505-3507)ttG>ttC	p.L1169F	COL7A1_ENST00000454817.1_Missense_Mutation_p.L1169F	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1169	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTCACCTCTCAAGGGTTCAT	0.587000													68	200					0	0	1	0	0
CSPG5	10675	broad.mit.edu	37	3	47619161	47619161	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:47619161C>A	ENST00000383738.2	-	2	2453	c.355G>T	c.(355-357)Gat>Tat	p.D119Y	CSPG5_ENST00000264723.4_Missense_Mutation_p.D119Y|CSPG5_ENST00000456150.1_5'UTR	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	119					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCTGGGCATCGCCGCTGCCC	0.692000													3	57					1	1	1	1	0
CDK5R1	8851	broad.mit.edu	37	17	30815244	30815244	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:30815244C>T	ENST00000313401.3	+	2	1295	c.606C>T	c.(604-606)gtC>gtT	p.V202V		NM_003885.2	NP_003876.1	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	202					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	8		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			CCAACGTGGTCTTCCTCTACA	0.642000													14	91					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132620365	132620365	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:132620365G>A	ENST00000315480.4	+	5	330	c.172G>A	c.(172-174)Gct>Act	p.A58T	USP20_ENST00000358355.1_Missense_Mutation_p.A58T|USP20_ENST00000372429.3_Missense_Mutation_p.A58T			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	58					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				AGAATCCTTTGCTGACCACAG	0.562000													37	51					0	0	1	0	0
C11orf58	10944	broad.mit.edu	37	11	16774368	16774368	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:16774368C>G	ENST00000228136.4	+	4	623	c.245C>G	c.(244-246)tCt>tGt	p.S82C	C11orf58_ENST00000422258.2_Missense_Mutation_p.S38C|C11orf58_ENST00000525684.1_Missense_Mutation_p.L62V			O00193	SMAP_HUMAN	chromosome 11 open reading frame 58	82										NS(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)	7						GAACTGGAGTCTCAATATCAG	0.348000													42	7					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53740952	53740952	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:53740952C>G	ENST00000333952.4	-	5	1193	c.1028G>C	c.(1027-1029)gGa>gCa	p.G343A	ZNF677_ENST00000598513.1_Missense_Mutation_p.G343A			Q86XU0	ZN677_HUMAN	zinc finger protein 677	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		AGGTTTCTCTCCAGTATGCAT	0.388000													6	41					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122756598	122756598	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:122756598C>A	ENST00000227349.2	+	2	338	c.41C>A	c.(40-42)tCt>tAt	p.S14Y	C11orf63_ENST00000531316.1_Missense_Mutation_p.S14Y|C11orf63_ENST00000307257.6_Missense_Mutation_p.S14Y	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	14										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TCTATTCAATCTCCTGTCCTT	0.393000													21	63					4.26978e-12	4.71709e-12	1	1	0
TBX4	9496	broad.mit.edu	37	17	59534930	59534930	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:59534930G>C	ENST00000393853.4	+	3	382	c.219G>C	c.(217-219)gaG>gaC	p.E73D	TBX4_ENST00000240335.1_Missense_Mutation_p.E73D			P57082	TBX4_HUMAN	T-box 4	73					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GGCTGCATGAGAAGGAGCTCT	0.597000													6	56					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42610592	42610592	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr22:42610592G>A	ENST00000359486.3	-	1	856	c.720C>T	c.(718-720)tcC>tcT	p.S240S	TCF20_ENST00000335626.4_Silent_p.S240S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	240	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						aggaggaggaggaAGCAGAAG	0.512000													3	45					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31332583	31332583	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr22:31332583C>T	ENST00000397641.3	-	17	2060	c.1652G>A	c.(1651-1653)aGa>aAa	p.R551K	MORC2_ENST00000215862.4_Missense_Mutation_p.R489K|MORC2_ENST00000469915.1_5'UTR			Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2								ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CATGTCCTTTCTGAATGTTCC	0.527000													9	70					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	54					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56093885	56093885	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr20:56093885G>A	ENST00000608263.1	-	4	1649	c.988C>T	c.(988-990)Cga>Tga	p.R330*	CTCFL_ENST00000608858.1_5'UTR|CTCFL_ENST00000608158.1_Nonsense_Mutation_p.R330*|CTCFL_ENST00000539382.1_Nonsense_Mutation_p.R125*|CTCFL_ENST00000608425.1_Nonsense_Mutation_p.R330*|CTCFL_ENST00000433949.3_Nonsense_Mutation_p.R125*|CTCFL_ENST00000481655.2_Nonsense_Mutation_p.R330*|CTCFL_ENST00000609232.1_Nonsense_Mutation_p.R330*|CTCFL_ENST00000371196.2_Nonsense_Mutation_p.R330*|CTCFL_ENST00000243914.3_Nonsense_Mutation_p.R330*|CTCFL_ENST00000432255.2_Nonsense_Mutation_p.R330*|CTCFL_ENST00000608903.1_Nonsense_Mutation_p.R68*|CTCFL_ENST00000502686.2_Nonsense_Mutation_p.R68*|CTCFL_ENST00000608440.1_Nonsense_Mutation_p.R330*|CTCFL_ENST00000429804.3_Nonsense_Mutation_p.R330*|CTCFL_ENST00000422869.2_Nonsense_Mutation_p.R330*|CTCFL_ENST00000423479.3_Nonsense_Mutation_p.R330*	NM_001269041.1	NP_001255970.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like						cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CGCCTGTGTCGGACGAGTTCT	0.433000													7	96					0	0	1	0	0
GBP1P1	400759	broad.mit.edu	37	1	89889944	89889944	+	RNA	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:89889944G>A	ENST00000513638.1	+	0	685					NR_003133.2																						AACTGACTGAGAAGATGGAGA	0.448000													47	107					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128807800	128807800	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:128807800C>A	ENST00000270861.5	+	5	1549	c.1275C>A	c.(1273-1275)aaC>aaA	p.N425K	PLK4_ENST00000514379.1_Missense_Mutation_p.N384K|PLK4_ENST00000515069.1_Missense_Mutation_p.N425K|PLK4_ENST00000507249.1_Intron|PLK4_ENST00000513090.1_Missense_Mutation_p.N393K	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	425					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						CCACAGACAACAATGCCAACA	0.368000													3	37					0.004672	0.00492684	1	1	0
METTL21A	151194	broad.mit.edu	37	2	208477805	208477805	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:208477805C>T	ENST00000411432.1	-	4	838	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	METTL21A_ENST00000406927.2_Missense_Mutation_p.E208K|METTL21A_ENST00000425132.1_Intron|METTL21A_ENST00000432416.1_Intron|METTL21A_ENST00000458426.1_Intron|METTL21A_ENST00000442521.1_Missense_Mutation_p.E208K|METTL21A_ENST00000448823.2_3'UTR|METTL21A_ENST00000272839.3_Missense_Mutation_p.E226K|METTL21A_ENST00000426075.1_Missense_Mutation_p.E208K|METTL21A_ENST00000448007.2_Missense_Mutation_p.E208K	NM_001127395.1	NP_001120867.1	Q8WXB1	MT21A_HUMAN	methyltransferase like 21A	208						integral to membrane	methyltransferase activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|stomach(1)	10						TTCTGTGCTTCGTAAATATGT	0.368000													21	70					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34011221	34011221	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr21:34011221C>T	ENST00000382499.2	-	31	4028	c.4029G>A	c.(4027-4029)ccG>ccA	p.P1343P	SYNJ1_ENST00000433931.2_Silent_p.P1343P|SYNJ1_ENST00000322229.7_Silent_p.P1304P|SYNJ1_ENST00000357345.3_Silent_p.P1288P|SYNJ1_ENST00000382491.3_Silent_p.P1257P	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1304	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding	p.P1304P(1)		breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						GACTTACTTGCGGTTGTGAGG	0.408000													4	147					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143994845	143994845	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:143994845G>A	ENST00000323110.2	-	6	979	c.977C>T	c.(976-978)aCg>aTg	p.T326M		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	326					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CTCAAAGAGCGTCATCAGCAA	0.627000									Familial Hyperaldosteronism type I				43	69					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146720574	146720574	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:146720574C>A	ENST00000392299.2	+	8	2869	c.2399C>A	c.(2398-2400)gCt>gAt	p.A800D	GRM1_ENST00000507907.1_Missense_Mutation_p.A800D|GRM1_ENST00000492807.2_Missense_Mutation_p.A800D|GRM1_ENST00000282753.1_Missense_Mutation_p.A800D|GRM1_ENST00000361719.2_Missense_Mutation_p.A800D|GRM1_ENST00000355289.4_Missense_Mutation_p.A800D			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	800					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATCTGGCTAGCTTTTGTGCCC	0.493000													26	69					2.47511e-08	2.68329e-08	1	1	0
FAM129A	116496	broad.mit.edu	37	1	184787960	184787960	+	Splice_Site	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:184787960C>T	ENST00000367511.3	-	9	1179		c.e9-1		FAM129A_ENST00000487074.1_Splice_Site	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A						negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GCCACCATCGCTGAGGTAGGA	0.562000													33	114					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19702051	19702051	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:19702051G>T	ENST00000397821.3	-	6	906	c.616C>A	c.(616-618)Cag>Aag	p.Q206K	SH3KBP1_ENST00000379698.4_Missense_Mutation_p.Q169K|SH3KBP1_ENST00000379697.3_Missense_Mutation_p.Q250K	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	206					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						TTCTTGGGCTGGATTGCTGCA	0.488000													3	72					1	1	1	1	0
MPRIP	23164	broad.mit.edu	37	17	17083388	17083388	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:17083388A>C	ENST00000395811.5	+	22	3120	c.3031A>C	c.(3031-3033)Aac>Cac	p.N1011H	MPRIP_ENST00000341712.4_Missense_Mutation_p.N1011H|MPRIP_ENST00000444976.1_Missense_Mutation_p.N973H|RP11-45M22.3_ENST00000584203.1_RNA|MPRIP_ENST00000395804.3_Missense_Mutation_p.N1011H	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	1011						cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GCAACTCAGAAACATCAGGTC	0.493000													5	25					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8449973	8449973	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:8449973C>T	ENST00000360416.3	-	12	1305	c.1167G>A	c.(1165-1167)caG>caA	p.Q389Q	MYH10_ENST00000269243.4_Silent_p.Q379Q|MYH10_ENST00000396239.1_Silent_p.Q379Q|MYH10_ENST00000379980.4_Silent_p.Q395Q	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	379	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						GGCAGAGCTTCTGCGCAACTG	0.418000													9	28					0	0	1	0	0
RFPL2	10739	broad.mit.edu	37	22	32589345	32589345	+	Translation_Start_Site	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr22:32589345G>A	ENST00000248980.4	-	0	121				RFPL2_ENST00000400236.3_Intron|RFPL2_ENST00000489846.1_5'UTR|RFPL2_ENST00000248983.4_Intron|RFPL2_ENST00000400237.1_Intron	NM_006605.3	NP_006596.2	O75678	RFPL2_HUMAN	ret finger protein-like 2								zinc ion binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	21						CCCACCCCCCGTCTTCAGAGA	0.493000													3	27					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2413265	2413265	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr20:2413265C>T	ENST00000202625.2	+	13	2158	c.2097C>T	c.(2095-2097)atC>atT	p.I699I	TGM6_ENST00000381423.1_3'UTR	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	699					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	GCTTTGTGATCGTCCATGTGG	0.567000													16	95					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187005188	187005188	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:187005188C>G	ENST00000296795.3	+	4	2452	c.2348C>G	c.(2347-2349)tCt>tGt	p.S783C	TLR3_ENST00000504367.1_Missense_Mutation_p.S506C	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3		TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GAAGACCAATCTCTCAAATTT	0.353000													17	61					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1789016	1789016	+	Silent	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:1789016C>G	ENST00000539485.1	-	24	3212	c.2979G>C	c.(2977-2979)ctG>ctC	p.L993L	ATP8B3_ENST00000525591.1_Silent_p.L946L|ATP8B3_ENST00000310127.6_Silent_p.L983L			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	983					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGTGCACCAGCAGGAGGC	0.632000													5	11					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130485503	130485503	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:130485503C>T	ENST00000373289.3	+	7	843	c.763C>T	c.(763-765)Cgc>Tgc	p.R255C	PTRH1_ENST00000419060.1_Intron|TTC16_ENST00000489226.1_3'UTR|TTC16_ENST00000393748.4_Missense_Mutation_p.R79C|PTRH1_ENST00000429848.1_Intron	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	255							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						CCAGCAGGCGCGCCAAGATGC	0.642000													45	6					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9018160	9018160	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:9018160T>C	ENST00000397910.4	-	25	37981	c.37778A>G	c.(37777-37779)tAc>tGc	p.Y12593C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12595	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCAGCCAGAGTACAGAAGGCC	0.537000													29	99					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670421	131670421	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131670421C>T	ENST00000259324.5	+	3	1501	c.978C>T	c.(976-978)atC>atT	p.I326I	LRRC8A_ENST00000372599.3_Silent_p.I326I|LRRC8A_ENST00000372600.4_Silent_p.I326I	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	326					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						CCTTCTACATCAGCCTAGTCA	0.567000													71	11					0	0	1	0	0
FKBP7	51661	broad.mit.edu	37	2	179343192	179343192	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:179343192A>G	ENST00000424785.2	-	1	93	c.35T>C	c.(34-36)aTt>aCt	p.I12T	FKBP7_ENST00000434643.2_Missense_Mutation_p.I12T|FKBP7_ENST00000464248.1_5'UTR	NM_001135212.1|NM_181342.2	NP_001128684.1|NP_851939.1	Q9Y680	FKBP7_HUMAN	FK506 binding protein 7	12					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			AAAGAAAACAATGAATCTGAA	0.493000													3	119					0	0	1	0	0
SMEK2	57223	broad.mit.edu	37	2	55791550	55791550	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:55791550T>A	ENST00000272313.5	-	13	2231	c.1904A>T	c.(1903-1905)gAt>gTt	p.D635V	SMEK2_ENST00000407823.3_Missense_Mutation_p.D688V|SMEK2_ENST00000345102.5_Missense_Mutation_p.D720V	NM_020463.2	NP_065196.1	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	720						microtubule organizing center|nucleus	protein binding			kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTCTTCTTCATCTTCATTAAA	0.358000													13	27					0	0	1	0	0
ARPC5L	81873	broad.mit.edu	37	9	127637310	127637310	+	Silent	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:127637310T>C	ENST00000353214.2	+	5	1531	c.279T>C	c.(277-279)atT>atC	p.I93I	ARPC5L_ENST00000259477.6_Silent_p.I93I|ARPC5L_ENST00000465124.1_3'UTR			Q9BPX5	ARP5L_HUMAN	actin related protein 2/3 complex, subunit 5-like	93					regulation of actin filament polymerization	cytoplasm|cytoskeleton	actin binding			large_intestine(2)|lung(1)	3						GCAGTGAGATTGAGCAGGCTG	0.502000													5	90					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433185	73433185	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:73433185G>A	ENST00000263666.4	-	10	2646	c.2532C>T	c.(2530-2532)gaC>gaT	p.D844D	PDZRN3_ENST00000479530.1_Silent_p.D561D|PDZRN3_ENST00000535920.1_Silent_p.D566D|PDZRN3_ENST00000462146.2_Silent_p.D501D|PDZRN3_ENST00000466780.1_Silent_p.D501D	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	844							ubiquitin-protein ligase activity|zinc ion binding	p.D844E(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCCGGCTCCCGTCGCTGGCTC	0.667000													28	38					0	0	1	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698707	111698707	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:111698707C>A	ENST00000340433.2	+	1	981	c.751C>A	c.(751-753)Cca>Aca	p.P251T		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	251							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						CACAGATCCACCACCCAAGAA	0.562000													4	120					1	1	1	1	0
TCHHL1	126637	broad.mit.edu	37	1	152058997	152058997	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:152058997C>G	ENST00000368806.1	-	3	1225	c.1161G>C	c.(1159-1161)atG>atC	p.M387I		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	387							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTTCATCTCTCATGTCAGATG	0.463000													16	135					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44221299	44221299	+	Silent	SNP	C	C	T	rs143048794	byFrequency	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:44221299C>T	ENST00000371554.1	+	12	2353	c.2139C>T	c.(2137-2139)ggC>ggT	p.G713G	HSP90AB1_ENST00000353801.3_Silent_p.G713G|HSP90AB1_ENST00000371646.5_Silent_p.G713G			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	713					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding	p.G713G(1)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTCTCGAGGGCGATGAGGATG	0.498000											OREG0017471	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	45					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917269	99917269	+	Silent	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:99917269T>C	ENST00000332397.6	+	9	1612	c.1428T>C	c.(1426-1428)tcT>tcC	p.S476S	SPDYE3_ENST00000437326.2_Silent_p.S99S	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	476										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						AGACCCACTCTCACATACCCT	0.532000													24	57					0	0	1	0	0
OTUD7A	161725	broad.mit.edu	37	15	31818621	31818621	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:31818621G>A	ENST00000382902.1	-	6	916	c.824C>T	c.(823-825)aCg>aTg	p.T275M	OTUD7A_ENST00000307050.4_Missense_Mutation_p.T268M			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	268	Catalytic (By similarity).|OTU.|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CAGCAGCTCCGTCCACTCCCG	0.682000													7	35					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245523	46245523	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:46245523C>T	ENST00000334344.6	+	15	3789	c.3617C>T	c.(3616-3618)aCg>aTg	p.T1206M	ARID2_ENST00000422737.1_Missense_Mutation_p.T1057M|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000444670.1_Missense_Mutation_p.T816M	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1206					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATGAGCGGAACGCAGACAGGA	0.488000			"""N, S, F"""		hepatocellular carcinoma								13	15					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7094110	7094110	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:7094110C>T	ENST00000399510.2	-	22	3073	c.2221G>A	c.(2221-2223)Gag>Aag	p.E741K	DLG4_ENST00000399506.2_Missense_Mutation_p.E698K|DLG4_ENST00000302955.6_Missense_Mutation_p.E695K	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	698					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TAGATCTCCTCAAAGCTGTCA	0.617000													23	58					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74637457	74637457	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:74637457G>A	ENST00000358632.4	-	3	774	c.79C>T	c.(79-81)Cgc>Tgc	p.R27C	CYP11A1_ENST00000419019.2_Missense_Mutation_p.R27C|CYP11A1_ENST00000541301.1_Intron|CYP11A1_ENST00000268053.6_Missense_Mutation_p.R185C	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	185					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TTCTTGATGCGCCTGTGCAGG	0.582000													4	69					0	0	1	0	0
RP11-383H13.1	0	broad.mit.edu	37	8	72755864	72755864	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:72755864C>T	ENST00000537896.1	+	1	498	c.228C>T	c.(226-228)tgC>tgT	p.C76C	MSC_ENST00000325509.4_Intron|RP11-383H13.1_ENST00000521467.1_Intron|RP11-383H13.1_ENST00000524152.1_5'UTR																lung(1)	1						CGAATCCTTGCGCGCCGCGCC	0.647000											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	39					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58154337	58154337	+	Missense_Mutation	SNP	G	G	A	rs142229998		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:58154337G>A	ENST00000295956.4	+	44	7534	c.7369G>A	c.(7369-7371)Ggt>Agt	p.G2457S	FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000484981.1_3'UTR|FLNB_ENST00000419752.2_Missense_Mutation_p.G2277S|FLNB_ENST00000348383.5_Missense_Mutation_p.G2416S|FLNB_ENST00000490882.1_Missense_Mutation_p.G2488S|FLNB_ENST00000429972.2_Missense_Mutation_p.G2446S|FLNB_ENST00000493452.1_Missense_Mutation_p.G2264S|FLNB_ENST00000358537.3_Missense_Mutation_p.G2433S|FLNB_ENST00000357272.4_3'UTR	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2457	Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CGTCAAATACGGTGGGCCCAA	0.532000													13	48					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11049568	11049568	+	RNA	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr21:11049568G>C	ENST00000470054.1	-	0	540									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAAAAGAACTGATCTAAGAGG	0.413000													4	118					0	0	1	0	0
HOXC13	3229	broad.mit.edu	37	12	54339012	54339012	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:54339012C>T	ENST00000243056.3	+	2	1121	c.965C>T	c.(964-966)tCg>tTg	p.S322L		NM_017410.2	NP_059106.2	P31276	HXC13_HUMAN	homeobox C13	322						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)|skin(1)	3						GTCAGCAAATCGAAAGCGCCT	0.577000			T	NUP98	AML								13	189					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123269135	123269135	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:123269135G>A	ENST00000451558.1	+	12	1608	c.1087G>A	c.(1087-1089)Gtt>Att	p.V363I	ASB15_ENST00000275699.3_Missense_Mutation_p.V363I|ASB15_ENST00000434204.1_Missense_Mutation_p.V363I|ASB15_ENST00000540573.1_Missense_Mutation_p.V363I|ASB15_ENST00000451215.1_Missense_Mutation_p.V363I			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	363					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						TAATAATGACGTTCATTGCAC	0.438000													35	41					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6911149	6911149	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrY:6911149G>C	ENST00000383032.1	+	7	834	c.187G>C	c.(187-189)Gag>Cag	p.E63Q	TBL1Y_ENST00000355162.2_Missense_Mutation_p.E63Q|TBL1Y_ENST00000346432.3_Missense_Mutation_p.E63Q	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	63	F-box-like.				transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						TGTAGAGGCTGAGATAAGCAT	0.527000													10	62					0	0	1	0	0
CMTM2	146225	broad.mit.edu	37	16	66621938	66621938	+	Silent	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:66621938A>G	ENST00000268595.2	+	4	814	c.663A>G	c.(661-663)aaA>aaG	p.K221K	CMTM2_ENST00000379486.2_Silent_p.K168K	NM_144673.2	NP_653274.1	Q8TAZ6	CKLF2_HUMAN	CKLF-like MARVEL transmembrane domain containing 2	221					chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		GAAAGGAAAAAGGACCCCAGC	0.522000													3	73					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													4	73					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123217380	123217380	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:123217380C>T	ENST00000371160.1	+	29	3324	c.3034C>T	c.(3034-3036)Cga>Tga	p.R1012*	STAG2_ENST00000354548.5_Nonsense_Mutation_p.R943*|STAG2_ENST00000371157.3_Nonsense_Mutation_p.R1012*|STAG2_ENST00000371144.3_Nonsense_Mutation_p.R1012*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.R1012*|STAG2_ENST00000218089.9_Nonsense_Mutation_p.R1012*|STAG2_ENST00000469481.1_Intron	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	1012					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding	p.R1012*(1)		breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						TAAACTACTTCGACAAGACAA	0.343000													34	0					0	0	1	0	0
FAM188A	80013	broad.mit.edu	37	10	15863726	15863726	+	Splice_Site	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:15863726C>T	ENST00000277632.3	-	9	951		c.e9-1		FAM188A_ENST00000477891.1_Splice_Site	NM_024948.2	NP_079224.1	Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A						apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						CCAAGAAGTTCTGCAAAAAAC	0.289000													8	28					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131671081	131671081	+	Silent	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131671081C>G	ENST00000259324.5	+	3	2161	c.1638C>G	c.(1636-1638)ctC>ctG	p.L546L	LRRC8A_ENST00000372599.3_Silent_p.L546L|LRRC8A_ENST00000372600.4_Silent_p.L546L	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	546					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						TCAAACGCCTCAAGGTGCTGC	0.592000													28	4					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85553028	85553028	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:85553028A>G	ENST00000295887.5	+	6	1060	c.637A>G	c.(637-639)Atg>Gtg	p.M213V		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	213					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GCAGTTTTATATGGTGTGTAT	0.338000													16	70					0	0	1	0	0
ZNF207	7756	broad.mit.edu	37	17	30696342	30696342	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:30696342A>G	ENST00000394670.4	+	11	1362	c.1193A>G	c.(1192-1194)tAt>tGt	p.Y398C	ZNF207_ENST00000341711.6_Missense_Mutation_p.Y299C|ZNF207_ENST00000321233.6_Missense_Mutation_p.Y382C|ZNF207_ENST00000577908.1_Missense_Mutation_p.Y398C|ZNF207_ENST00000342555.6_Missense_Mutation_p.Y401C|ZNF207_ENST00000394673.2_Missense_Mutation_p.Y367C	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	382						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTACCTAAGTATCAACGTAAT	0.502000													24	32					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53994342	53994342	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:53994342C>T	ENST00000396328.1	-	12	1797	c.1558G>A	c.(1558-1560)Gag>Aag	p.E520K	WDR72_ENST00000360509.5_Missense_Mutation_p.E520K|WDR72_ENST00000559418.1_Missense_Mutation_p.E530K|WDR72_ENST00000557913.1_Missense_Mutation_p.E517K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	520										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTAAACTTCTCTGGTGACATC	0.294000													10	64					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48158582	48158582	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:48158582T>C	ENST00000418331.2	+	10	2253	c.1901T>C	c.(1900-1902)gTa>gCa	p.V634A		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	634	Fibronectin type-III 7.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						AACATTGATGTAAGTACCAAC	0.408000													12	52					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131669702	131669702	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131669702C>T	ENST00000259324.5	+	3	782	c.259C>T	c.(259-261)Ctg>Ttg	p.L87L	LRRC8A_ENST00000372599.3_Silent_p.L87L|LRRC8A_ENST00000372600.4_Silent_p.L87L	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	87					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						CTCCACCATTCTGCCGACCCC	0.617000													59	10					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72412694	72412694	+	Splice_Site	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:72412694C>G	ENST00000359373.5	-	16	3153	c.2302G>C	c.(2302-2304)Gag>Cag	p.E768Q	ARAP1-AS2_ENST00000500163.2_RNA|ARAP1_ENST00000429686.1_Splice_Site_p.E462Q|ARAP1_ENST00000455638.2_Splice_Site_p.E768Q|ARAP1_ENST00000393609.3_Splice_Site_p.E768Q|ARAP1_ENST00000393605.3_Splice_Site_p.E528Q|ARAP1_ENST00000426523.1_Splice_Site_p.E523Q|ARAP1_ENST00000334211.8_Splice_Site_p.E523Q			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	768	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						TGGCACCCACCTTCCCGGGCC	0.632000													15	120					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49947848	49947848	+	Silent	SNP	G	G	A	rs151189958		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:49947848G>A	ENST00000417270.1	-	5	1800	c.1107C>T	c.(1105-1107)ggC>ggT	p.G369G	CTD-2330K9.3_ENST00000419183.1_Intron|MON1A_ENST00000296473.3_Silent_p.G458G|MON1A_ENST00000455683.2_Silent_p.G296G			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	361							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCCAGGCCTCGCCCTCGCGAA	0.597000													8	43					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794836	30794836	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:30794836G>A	ENST00000262525.4	-	3	1020	c.813C>T	c.(811-813)ttC>ttT	p.F271F		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			AGCTGCGGTAGAAAGCCCGGC	0.632000													13	33					0	0	1	0	0
TSSK6	83983	broad.mit.edu	37	19	19626255	19626255	+	Translation_Start_Site	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:19626255C>T	ENST00000360913.3	-	0	583				TSSK6_ENST00000585580.3_De_novo_Start_OutOfFrame			Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6						multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16						CTAGGGCGCACGGGGGGCAGG	0.652000													9	21					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30704505	30704505	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:30704505C>T	ENST00000256246.2	-	1	2103	c.2029G>A	c.(2029-2031)Gaa>Aaa	p.E677K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	677										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATTTCAATTTCACTTTCCAAT	0.289000													6	19					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123921142	123921142	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:123921142C>T	ENST00000373855.1	+	31	5034	c.4774C>T	c.(4774-4776)Cag>Tag	p.Q1592*	CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000238341.5_Nonsense_Mutation_p.Q1592*|CNTRL_ENST00000373850.1_Nonsense_Mutation_p.Q1040*|CNTRL_ENST00000373844.1_Nonsense_Mutation_p.Q37*			Q7Z7A1	CNTRL_HUMAN	centriolin	1592					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GGTGACAAGTCAGCAGCAGGA	0.463000													70	13					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167570440	167570440	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:167570440G>A	ENST00000366834.1	-	1	1377	c.880C>T	c.(880-882)Cgg>Tgg	p.R294W		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	294						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		AAGACCCTCCGATAGGAGCTC	0.597000													3	33					0	0	1	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499546	59499546	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:59499546C>G	ENST00000307144.4	+	1	505	c.407C>G	c.(406-408)gCa>gGa	p.A136G	MYO1E_ENST00000288235.4_Intron	NM_033195.2	NP_149972.1	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	136					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)	10					NADH(DB00157)	TTTGTCACAGCAAACTCCAAC	0.433000													26	80					0	0	1	0	0
FXR1	8087	broad.mit.edu	37	3	180666136	180666136	+	Splice_Site	SNP	T	T	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:180666136T>A	ENST00000357559.4	+	5	656	c.272T>A	c.(271-273)tTt>tAt	p.F91Y	FXR1_ENST00000468861.1_Splice_Site_p.F6Y|FXR1_ENST00000480918.1_Splice_Site_p.F78Y|FXR1_ENST00000445140.2_Splice_Site_p.F91Y|FXR1_ENST00000491062.1_Splice_Site_p.F42Y|FXR1_ENST00000305586.7_Splice_Site_p.F6Y	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	91					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GTCTTTTAGTTTTATGTCATT	0.318000													4	25					0	0	1	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													3	11					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121882333	121882333	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:121882333C>A	ENST00000377069.4	-	15	2423	c.2017G>T	c.(2017-2019)Gag>Tag	p.E673*	KDM2B_ENST00000542973.1_Nonsense_Mutation_p.E72*|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Nonsense_Mutation_p.E704*	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	704					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CCCTCTGACTCCTTAATCTGC	0.602000													14	101					0.00400662	0.00426393	1	1	0
OR5D13	390142	broad.mit.edu	37	11	55541619	55541619	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:55541619C>T	ENST00000361760.1	+	1	706	c.706C>T	c.(706-708)Cgc>Tgc	p.R236C		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	236			R -> L (in dbSNP:rs7124871).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TGCAAGTGGGCGCCAGAAAAC	0.408000													19	58					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	630113	630113	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:630113C>T	ENST00000588649.2	-	3	333	c.249G>A	c.(247-249)gtG>gtA	p.V83V		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	83					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCCTGTTCACCACCACCT	0.672000													18	86					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132670204	132670204	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:132670204A>C	ENST00000370818.3	-	8	2136	c.1691T>G	c.(1690-1692)cTt>cGt	p.L564R	GPC3_ENST00000394299.2_Missense_Mutation_p.L587R|GPC3_ENST00000543339.1_Missense_Mutation_p.L510R	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	564						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					GCTGGTGAGAAGCTTCAGCGG	0.562000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				57	3					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	650821	650821	+	Silent	SNP	G	G	A	rs151264305	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:650821G>A	ENST00000576778.1	-	1	1770	c.429C>T	c.(427-429)gcC>gcT	p.A143A	GEMIN4_ENST00000437269.1_Silent_p.A154A|GEMIN4_ENST00000319004.5_Silent_p.A154A			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	154					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CCACGTCTTCGGCAGAAGTGT	0.567000													7	75					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44255546	44255546	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:44255546G>A	ENST00000371505.4	-	2	139	c.17C>T	c.(16-18)aCg>aTg	p.T6M	RP11-444E17.6_ENST00000505802.1_Intron|TCTE1_ENST00000371503.3_De_novo_Start_InFrame|TMEM151B_ENST00000438774.2_Intron	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	6										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCTGATGTCGTTACGGTATC	0.557000													6	24					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228462331	228462331	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:228462331C>T	ENST00000570156.2	+	24	6941	c.6867C>T	c.(6865-6867)ggC>ggT	p.G2289G	OBSCN_ENST00000422127.1_Silent_p.G1914G|OBSCN_ENST00000284548.11_Silent_p.G1914G|OBSCN_ENST00000366709.4_5'UTR|RP5-1139B12.3_ENST00000602529.1_RNA|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Silent_p.G761G	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1274	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGAGGGCGGCGAGGCCACCT	0.627000													7	16					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	534286	534286	+	Missense_Mutation	SNP	C	C	G	rs104894228		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:534286C>G	ENST00000417302.1	-	2	224	c.37G>C	c.(37-39)Ggt>Cgt	p.G13R	HRAS_ENST00000397594.1_Missense_Mutation_p.G13R|HRAS_ENST00000311189.7_Missense_Mutation_p.G13R|HRAS_ENST00000451590.1_Missense_Mutation_p.G13R|HRAS_ENST00000397596.2_Missense_Mutation_p.G13R|HRAS_ENST00000468682.2_5'UTR	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	13			G -> C (in FCSS).|G -> D (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(70)|p.G13S(9)|p.G13C(8)|p.G12_G13insAG(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			18	10					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796588	127796588	+	Silent	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:127796588G>A	ENST00000556132.1	-	6	3447	c.2583C>T	c.(2581-2583)gaC>gaT	p.D861D	SOGA3_ENST00000368268.2_Silent_p.D861D|SOGA3_ENST00000465909.2_Silent_p.D861D|SOGA3_ENST00000474293.2_5'UTR|SOGA3_ENST00000481848.2_Silent_p.D861D|SOGA3_ENST00000525778.1_Silent_p.D861D	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	861						integral to membrane		p.D861D(1)									TGCGGCTGCCGTCGTCCTCCT	0.642000													25	47					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24573026	24573026	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:24573026T>G	ENST00000319715.4	+	9	1373	c.941T>G	c.(940-942)tTt>tGt	p.F314C	RBBP6_ENST00000381039.3_Missense_Mutation_p.F314C|RBBP6_ENST00000348022.2_Missense_Mutation_p.F314C	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	314					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		GCCAATAAATTTTTACGACAG	0.333000													5	60					0	0	1	0	0
MPRIP	23164	broad.mit.edu	37	17	17083384	17083384	+	Silent	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:17083384C>T	ENST00000395811.5	+	22	3116	c.3027C>T	c.(3025-3027)ctC>ctT	p.L1009L	MPRIP_ENST00000341712.4_Silent_p.L1009L|MPRIP_ENST00000444976.1_Silent_p.L971L|RP11-45M22.3_ENST00000584203.1_RNA|MPRIP_ENST00000395804.3_Silent_p.L1009L	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	1009						cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						CCCGGCAACTCAGAAACATCA	0.488000													5	25					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8393774	8393774	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:8393774C>G	ENST00000360416.3	-	35	4906	c.4768G>C	c.(4768-4770)Gaa>Caa	p.E1590Q	MYH10_ENST00000269243.4_Missense_Mutation_p.E1559Q|MYH10_ENST00000396239.1_Missense_Mutation_p.E1580Q|MYH10_ENST00000379980.4_Missense_Mutation_p.E1575Q	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1559					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TTGGCATCTTCCGTGGCCTGG	0.542000													3	96					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	176					0	0	1	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32929352	32929352	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:32929352A>T	ENST00000361627.3	+	12	3100	c.2378A>T	c.(2377-2379)aAa>aTa	p.K793I	ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.K604I|ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.K604I	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	793					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		ACATGTGAGAAAACAGTTTCT	0.348000													14	49					0	0	1	0	0
CXCR3	2833	broad.mit.edu	37	X	70836460	70836460	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:70836460G>A	ENST00000373691.4	-	2	1166	c.1003C>T	c.(1003-1005)Cgc>Tgc	p.R335C	CXCR3_ENST00000373693.3_Missense_Mutation_p.R288C	NM_001142797.1	NP_001136269.1	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3	288					cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|central_nervous_system(2)|large_intestine(2)|lung(3)|ovary(2)	10	Renal(35;0.156)					CCACAGTTGCGGGCCAAAGCG	0.632000													16	16					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr13:25161397C>G	ENST00000453498.1	+	0	921				TPTE2P6_ENST00000440905.1_RNA																							TGAAACATCTCTACAACTGGA	0.343000													4	48					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3277363	3277363	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:3277363C>T	ENST00000382004.3	-	9	1261	c.950G>A	c.(949-951)aGc>aAc	p.S317N	RFX3_ENST00000302303.1_Missense_Mutation_p.S317N|RFX3_ENST00000358730.2_Missense_Mutation_p.S317N	NM_001282116.1|NM_134428.1	NP_001269045.1|NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	317					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		ATGATGTTGGCTTTGGGCAAT	0.403000													32	67					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109927742	109927742	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:109927742C>T	ENST00000342494.3	+	8	1158	c.563C>T	c.(562-564)gCg>gTg	p.A188V	UBE3B_ENST00000536398.1_Missense_Mutation_p.A188V|UBE3B_ENST00000434735.2_Missense_Mutation_p.A188V|UBE3B_ENST00000340074.5_Missense_Mutation_p.A188V|UBE3B_ENST00000280774.5_Missense_Mutation_p.A188V|UBE3B_ENST00000537063.1_Missense_Mutation_p.A188V|UBE3B_ENST00000540230.1_Missense_Mutation_p.A188V	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	188					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CTTCGACCAGCGATGAACCAC	0.443000													15	188					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151962241	151962241	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:151962241G>C	ENST00000355193.2	-	8	1284	c.1066C>G	c.(1066-1068)Cag>Gag	p.Q356E	KMT2C_ENST00000262189.6_Missense_Mutation_p.Q356E					lysine (K)-specific methyltransferase 2C									p.Q356K(4)									CAAAAGAACTGATCTAAGAGG	0.413000													12	271					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71798289	71798289	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:71798289C>G	ENST00000299980.4	-	9	1323	c.882G>C	c.(880-882)ttG>ttC	p.L294F	AP1G1_ENST00000433195.2_Missense_Mutation_p.L317F|AP1G1_ENST00000423132.2_Missense_Mutation_p.L297F|AP1G1_ENST00000569748.1_Missense_Mutation_p.L294F|AP1G1_ENST00000393512.3_Missense_Mutation_p.L297F	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	294					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				CCATGATAGTCAAAACCGTTT	0.363000													7	31					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327275	16327275	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:16327275G>A	ENST00000244769.4	-	8	2203	c.1267C>T	c.(1267-1269)Cac>Tac	p.H423Y	ATXN1_ENST00000436367.1_Missense_Mutation_p.H423Y	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	423					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TAGGACCGGTGGCCAGGCTTC	0.622000													75	80					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148950982	148950982	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:148950982G>C	ENST00000335870.2	+	5	1092	c.964G>C	c.(964-966)Gag>Cag	p.E322Q		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			TTCTGAGTGTGAGATCACCTT	0.567000													4	43					0	0	1	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21934840	21934840	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:21934840G>A	ENST00000542643.2	-	18	1464	c.1162C>T	c.(1162-1164)Cgg>Tgg	p.R388W	RAP1GAP_ENST00000290101.4_Missense_Mutation_p.R452W|RAP1GAP_ENST00000374765.4_Missense_Mutation_p.R388W|RAP1GAP_ENST00000374763.2_Missense_Mutation_p.R388W|RAP1GAP_ENST00000374761.2_Missense_Mutation_p.R419W	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	388	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GCCCGCGTCCGCTCCTGTGGG	0.647000													3	31					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150422486	150422486	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr5:150422486G>A	ENST00000389378.2	-	10	1561	c.973C>T	c.(973-975)Cgg>Tgg	p.R325W	TNIP1_ENST00000521591.1_Missense_Mutation_p.R325W|TNIP1_ENST00000523200.1_Missense_Mutation_p.R325W|TNIP1_ENST00000523338.1_Missense_Mutation_p.R325W|TNIP1_ENST00000524280.1_Missense_Mutation_p.R325W|TNIP1_ENST00000518977.1_Missense_Mutation_p.R325W|TNIP1_ENST00000522226.1_Missense_Mutation_p.R325W|TNIP1_ENST00000315050.7_Missense_Mutation_p.R325W|TNIP1_ENST00000521423.1_Intron|TNIP1_ENST00000520931.1_Missense_Mutation_p.R272W	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	325	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCATGGACCGGAAATGCTGG	0.552000													4	256					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57522240	57522240	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:57522240G>T	ENST00000420713.1	+	2	226	c.114G>T	c.(112-114)caG>caT	p.Q38H		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						ATGCTCAGCAGAATTTATATA	0.373000													5	57					0.000274275	0.000294592	1	1	0
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:160589601delT	ENST00000302035.6	-	5	1178	c.829delA	c.(829-831)agcfs	p.S277fs	SLAMF1_ENST00000355199.3_Frame_Shift_Del_p.S277fs|SLAMF1_ENST00000235739.5_Frame_Shift_Del_p.S247fs|SLAMF1_ENST00000538290.1_Intron	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	277					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433													8	176	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59725208	59725209	+	RNA	INS	-	-	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:59725208_59725209insT	ENST00000606382.1	-	0	433																											cttcctcctcctttctccttct	0.376													2	4	---	---	---	---					
H1FOO	132243	broad.mit.edu	37	3	129268107	129268108	+	Frame_Shift_Ins	INS	-	-	A	rs150160917	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:129268107_129268108insA	ENST00000324382.2	+	3	647_648	c.642_643insA	c.(643-645)aggfs	p.R215fs	H1FOO_ENST00000503977.1_Frame_Shift_Ins_p.R76fs	NM_153833.1	NP_722575.1	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	215					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			endometrium(1)|lung(4)|skin(1)	6						CGGGAGAGGCTAGGAAGGTGCC	0.653													3	6	---	---	---	---					
PILRB	29990	broad.mit.edu	37	7	99956513	99956514	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:99956513_99956514insT	ENST00000610247.1	+	16	2761_2762	c.265_266insT	c.(265-267)attfs	p.I89fs	PILRB_ENST00000609309.1_Frame_Shift_Ins_p.I89fs|STAG3L5P-PVRIG2P-PILRB_ENST00000310771.4_RNA|PILRB_ENST00000452089.1_Frame_Shift_Ins_p.I89fs|PILRB_ENST00000444073.1_Frame_Shift_Ins_p.I89fs|PILRB_ENST00000448382.1_Intron			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta		Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCGCCTTCCATTCACAAGGAT	0.550													53	105	---	---	---	---					
SPAG6	9576	broad.mit.edu	37	10	22690092	22690093	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:22690092_22690093insA	ENST00000376603.2	+	9	1570_1571	c.1428_1429insA	c.(1429-1431)aaafs	p.K477fs	SPAG6_ENST00000313311.6_Frame_Shift_Ins_p.K401fs|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376601.1_Frame_Shift_Ins_p.K162fs|SPAG6_ENST00000538630.1_Frame_Shift_Ins_p.K376fs|SPAG6_ENST00000376624.3_Frame_Shift_Ins_p.K401fs|SPAG6_ENST00000490361.1_3'UTR			O75602	SPAG6_HUMAN	sperm associated antigen 6	401					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						ATTTCTAGAGTAAAAAAGCCAT	0.327													16	49	---	---	---	---					
FBXW4	6468	broad.mit.edu	37	10	103454358	103454360	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:103454358_103454360delCCT	ENST00000331272.7	-	1	656_658	c.38_40delAGG	c.(37-42)gaggcg>gcg	p.E13del		NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	13					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TCCCGAGCCGcctcctcctcctc	0.754													2	4	---	---	---	---					
MARK2	2011	broad.mit.edu	37	11	63668273	63668276	+	Frame_Shift_Del	DEL	ATGA	ATGA	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:63668273_63668276delATGA	ENST00000402010.2	+	10	1489_1492	c.910_913delATGA	c.(910-915)atgaatfs	p.MN304fs	MARK2_ENST00000377809.4_Frame_Shift_Del_p.MN304fs|MARK2_ENST00000509502.2_Frame_Shift_Del_p.MN271fs|MARK2_ENST00000315032.8_Frame_Shift_Del_p.MN304fs|MARK2_ENST00000377810.3_Frame_Shift_Del_p.MN271fs|MARK2_ENST00000413835.2_Frame_Shift_Del_p.MN304fs|MARK2_ENST00000508192.1_Frame_Shift_Del_p.MN304fs|MARK2_ENST00000350490.7_Frame_Shift_Del_p.MN304fs|MARK2_ENST00000425897.2_Frame_Shift_Del_p.MN271fs|MARK2_ENST00000408948.3_Frame_Shift_Del_p.MN271fs|MARK2_ENST00000513765.2_Frame_Shift_Del_p.MN271fs|MARK2_ENST00000361128.5_Frame_Shift_Del_p.MN304fs|MARK2_ENST00000502399.3_Frame_Shift_Del_p.MN304fs	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	304	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						AGATCGATGGATGAATGTGGGTCA	0.564													95	144	---	---	---	---					
EEF1DP3	196549	broad.mit.edu	37	13	32439751	32439754	+	RNA	DEL	TGTG	TGTG	-	rs113640364		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr13:32439751_32439754delTGTG	ENST00000428783.1	+	0	99																											AGAATGATTTtgtgtgtgtgtgtg	0.422													4	2	---	---	---	---					
FAM155A	728215	broad.mit.edu	37	13	108518687	108518689	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr13:108518687_108518689delCTG	ENST00000375915.2	-	1	394_396	c.256_258delCAG	c.(256-258)cagdel	p.Q86del		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	86	Poly-Gln.					integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						gccgctgcctctgctgctgctgc	0.719													7	31	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45756135	45756137	+	RNA	DEL	CAC	CAC	-	rs111650936	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:45756135_45756137delCAC	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000558536.1_RNA|RP11-519G16.3_ENST00000560647.1_RNA																							tccacaccatcaccaccaccacc	0.552													2	4	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58926335	58926336	+	RNA	INS	-	-	C	rs113534201	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:58926335_58926336insC	ENST00000500117.1	+	0	679																											caccaccatcacccccactact	0.535													5	1	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81241347	81241349	+	RNA	DEL	TCT	TCT	-	rs72082520		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:81241347_81241349delTCT	ENST00000337114.4	-	0	760				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TTTATGTGGGTCttttttttttt	0.399													3	4	---	---	---	---