Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RBM26	64062	broad.mit.edu	37	13	79939829	79939829	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:79939829T>C	ENST00000438737.2	-	9	1741	c.1301A>G	c.(1300-1302)aAt>aGt	p.N434S	RBM26_ENST00000267229.7_Missense_Mutation_p.N434S|RBM26_ENST00000438724.1_Missense_Mutation_p.N434S			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	434					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GGCTTCAGGATTGTAGCCATC	0.353000													7	62					0	0	0.003080	0	0
BTN3A1	11119	broad.mit.edu	37	6	26407948	26407948	+	Silent	SNP	G	G	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:26407948G>T	ENST00000289361.6	+	4	851	c.483G>T	c.(481-483)ggG>ggT	p.G161G	BTN3A1_ENST00000414912.2_Intron|BTN3A1_ENST00000425234.2_Silent_p.G161G|BTN3A1_ENST00000476549.2_Silent_p.G161G	NM_001145008.1|NM_001145009.1|NM_007048.5	NP_001138480.1|NP_001138481.1|NP_008979.3	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1	161	Ig-like V-type 2.				lipid metabolic process	integral to membrane				breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						AGGATGGAGGGATCCATCTGG	0.517000													9	118					1.12685e-05	1.18991e-05	0.004482	1	0
SPN	6693	broad.mit.edu	37	16	29676187	29676187	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:29676187G>A	ENST00000360121.3	+	2	1230	c.1138G>A	c.(1138-1140)Gag>Aag	p.E380K	SPN_ENST00000395389.2_Missense_Mutation_p.E380K	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	380					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						GGTGGCCAGTGAGGATGGGGC	0.652000													3	14					0	0	0.000602	0	0
KRI1	65095	broad.mit.edu	37	19	10670041	10670041	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:10670041G>A	ENST00000312962.6	-	12	1225	c.1206C>T	c.(1204-1206)ctC>ctT	p.L402L	KRI1_ENST00000361821.5_Silent_p.L398L	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	402	Glu-rich.									NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GCACCTGCATGAGCTGGTCGT	0.602000													10	34					0	0	0.006214	0	0
NBR1	4077	broad.mit.edu	37	17	41329983	41329983	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:41329983C>G	ENST00000422280.1	+	3	592	c.133C>G	c.(133-135)Caa>Gaa	p.Q45E	NBR1_ENST00000389312.4_Missense_Mutation_p.Q45E|NBR1_ENST00000341165.6_Missense_Mutation_p.Q45E|NBR1_ENST00000589872.1_Missense_Mutation_p.Q45E|NBR1_ENST00000590996.1_Missense_Mutation_p.Q45E|NBR1_ENST00000542611.1_Intron	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	45	OPR.				macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GAATACTATTCAAATAAAATA	0.308000													3	28					0	0	0.004672	0	0
ZNF574	64763	broad.mit.edu	37	19	42584035	42584035	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:42584035C>T	ENST00000600245.1	+	2	1932	c.1277C>T	c.(1276-1278)cCa>cTa	p.P426L	ZNF574_ENST00000359044.4_Missense_Mutation_p.P426L|ZNF574_ENST00000222339.7_Missense_Mutation_p.P516L|CTB-59C6.3_ENST00000594531.1_RNA			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	426	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				ACACCAGTCCCACCAGAGGAA	0.587000													10	168					0	0	0.008291	0	0
OR2L3	391192	broad.mit.edu	37	1	248224758	248224758	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:248224758C>G	ENST00000359959.3	+	1	775	c.775C>G	c.(775-777)Cta>Gta	p.L259V	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTACACTTATCTACGTCCAAG	0.493000													3	122					0	0	0.004672	0	0
PKN2	5586	broad.mit.edu	37	1	89290038	89290038	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:89290038G>A	ENST00000370521.3	+	18	2747	c.2388G>A	c.(2386-2388)gtG>gtA	p.V796V	PKN2_ENST00000544045.1_Silent_p.V470V|PKN2_ENST00000370505.3_Silent_p.V639V|PKN2_ENST00000370513.5_Silent_p.V748V	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	796	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		AGGGCTTTGTGAAAATTGCTG	0.308000													8	54					0	0	0.004482	0	0
DZANK1	55184	broad.mit.edu	37	20	18374906	18374906	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:18374906G>C	ENST00000357236.4	-	17	2017	c.1358C>G	c.(1357-1359)tCc>tGc	p.S453C	DZANK1_ENST00000329494.5_Intron|DZANK1_ENST00000487128.1_5'UTR|DZANK1_ENST00000358866.6_Missense_Mutation_p.S567C|DZANK1_ENST00000262547.5_Missense_Mutation_p.S567C			Q9NVP4	CT012_HUMAN	double zinc ribbon and ankyrin repeat domains 1	394						intracellular	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(10)	19						ACCCCAGCTGGACCTGCTGCC	0.512000													10	17					0	0	0.008291	0	0
DDB2	1643	broad.mit.edu	37	11	47236784	47236784	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:47236784G>C	ENST00000256996.4	+	1	292	c.97G>C	c.(97-99)Gag>Cag	p.E33Q	DDB2_ENST00000378600.3_Missense_Mutation_p.E33Q|DDB2_ENST00000378601.3_Missense_Mutation_p.E33Q|DDB2_ENST00000378603.3_Missense_Mutation_p.E33Q	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	33					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						GCTGGAGCCCGAGGCCAAGAA	0.612000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				3	161					0	0	0.004672	0	0
C9orf172	389813	broad.mit.edu	37	9	139741083	139741083	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:139741083C>T	ENST00000436881.1	+	1	2217	c.2217C>T	c.(2215-2217)atC>atT	p.I739I		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	739										endometrium(2)|large_intestine(1)|lung(6)	9						TCTCGCGCATCGCGCGTGTCG	0.706000													9	9					0	0	0.004482	0	0
ZNF91	7644	broad.mit.edu	37	19	23545372	23545372	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:23545372C>G	ENST00000300619.7	-	4	614	c.409G>C	c.(409-411)Gaa>Caa	p.E137Q	ZNF91_ENST00000397082.2_Missense_Mutation_p.E105Q|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	137						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTATAACCTTCTTTGTGCACC	0.299000													23	60					0	0	0.005443	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	67					0	0	0.003163	0	0
TENM2	57451	broad.mit.edu	37	5	167673915	167673915	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:167673915G>A	ENST00000519204.1	+	26	5726	c.5608G>A	c.(5608-5610)Gaa>Aaa	p.E1870K	TENM2_ENST00000403607.2_Missense_Mutation_p.E1815K|TENM2_ENST00000520394.1_Missense_Mutation_p.E1752K|TENM2_ENST00000518659.1_Missense_Mutation_p.E1991K|TENM2_ENST00000545108.1_Missense_Mutation_p.E1990K					teneurin transmembrane protein 2																		CAACCCGCCTGAAAGCAATGC	0.557000													21	82					0	0	0.008871	0	0
MOB2	81532	broad.mit.edu	37	11	1491480	1491480	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:1491480G>A	ENST00000329957.6	-	5	918	c.729C>T	c.(727-729)ggC>ggT	p.G243G	MOB2_ENST00000526462.1_5'UTR	NM_001172223.1	NP_001165694.1	Q70IA6	MOB2_HUMAN	MOB kinase activator 2	212						nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|kidney(2)|lung(1)	4						TGTGGACCCCGCCGGCCCCGC	0.682000													11	32					0	0	0.008291	0	0
PRDM9	56979	broad.mit.edu	37	5	23521274	23521274	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:23521274C>G	ENST00000296682.3	+	6	676	c.494C>G	c.(493-495)tCa>tGa	p.S165*		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	165					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGACAGCACTCAAGACTAAAA	0.453000										HNSCC(3;0.000094)			14	69					0	0	0.001855	0	0
C2orf78	388960	broad.mit.edu	37	2	74043855	74043855	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:74043855C>T	ENST00000409561.1	+	3	2626	c.2505C>T	c.(2503-2505)ctC>ctT	p.L835L		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	835										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TGACCAGTCTCCGGTCACTGC	0.507000													14	79					0	0	0.004007	0	0
FAT2	2196	broad.mit.edu	37	5	150925577	150925577	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:150925577G>C	ENST00000261800.5	-	9	5123	c.5111C>G	c.(5110-5112)tCt>tGt	p.S1704C		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1704	Cadherin 15.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAGTTCATAGAGAAGACTCC	0.448000													36	47					0	0	0.003755	0	0
RASGRF2	5924	broad.mit.edu	37	5	80369170	80369170	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:80369170C>T	ENST00000265080.4	+	5	853	c.786C>T	c.(784-786)ctC>ctT	p.L262L	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	262	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TTCACCAGCTCTACATCCTGG	0.512000													9	43					0	0	0.008291	0	0
SLC26A3	1811	broad.mit.edu	37	7	107408296	107408296	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:107408296G>A	ENST00000340010.5	-	19	2304	c.2120C>T	c.(2119-2121)tCa>tTa	p.S707L	SLC26A3_ENST00000422236.2_Missense_Mutation_p.S594L	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	707	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						GAAAAATATTGAGCTTTTCAC	0.323000													8	26					0	0	0.003080	0	0
PTPN23	25930	broad.mit.edu	37	3	47447452	47447452	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:47447452C>T	ENST00000265562.4	+	6	539	c.462C>T	c.(460-462)ttC>ttT	p.F154F	PTPN23_ENST00000431726.1_Silent_p.F28F	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	154	BRO1.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCGGCGCCTTCGCCTACCTAC	0.612000													7	22					0	0	0.001984	0	0
ZNF45	7596	broad.mit.edu	37	19	44417605	44417605	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:44417605G>C	ENST00000269973.5	-	10	3073	c.1983C>G	c.(1981-1983)gtC>gtG	p.V661V	ZNF45_ENST00000589703.1_Silent_p.V661V|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	661					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						CATCAGCATGGACTCGCTGAT	0.433000													10	94					0	0	0.013537	0	0
TTN	7273	broad.mit.edu	37	2	179501355	179501355	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:179501355A>G	ENST00000589042.1	-	225	41323	c.41099T>C	c.(41098-41100)gTt>gCt	p.V13700A	TTN_ENST00000359218.5_Missense_Mutation_p.V4760A|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V4827A|TTN_ENST00000591111.1_Missense_Mutation_p.V12059A|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V4635A|TTN_ENST00000342992.6_Missense_Mutation_p.V11132A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12059	Ig-like 93.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGAGCCAACGAACTCTGA	0.463000													6	63					0	0	0.001168	0	0
PFKFB2	5208	broad.mit.edu	37	1	207242832	207242832	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:207242832C>T	ENST00000367080.3	+	11	1175	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	PFKFB2_ENST00000411990.2_Nonsense_Mutation_p.R253*|PFKFB2_ENST00000541914.1_Nonsense_Mutation_p.R165*|PFKFB2_ENST00000473310.1_3'UTR|PFKFB2_ENST00000367079.2_Nonsense_Mutation_p.R351*|PFKFB2_ENST00000545806.1_Nonsense_Mutation_p.R318*	NM_006212.2	NP_006203.2	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	351	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					GTTTGCACTTCGAGATCAAGA	0.463000													6	79					0	0	0.001168	0	0
OAZ1	4946	broad.mit.edu	37	19	2271908	2271908	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:2271908A>G	ENST00000583542.4	+	4	493	c.419A>G	c.(418-420)tAc>tGc	p.Y140C	OAZ1_ENST00000588673.2_Missense_Mutation_p.Y169C|OAZ1_ENST00000602676.2_Missense_Mutation_p.Y140C|OAZ1_ENST00000582888.4_Missense_Mutation_p.Y138C|OAZ1_ENST00000322297.4_Missense_Mutation_p.Y139C			P54368	OAZ1_HUMAN	ornithine decarboxylase antizyme 1						polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	ornithine decarboxylase inhibitor activity			endometrium(1)|lung(2)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	L-Ornithine(DB00129)	GGCAGCCTCTACATCGAGATC	0.627000													9	16					0	0	0.004482	0	0
CD68	968	broad.mit.edu	37	17	7483018	7483018	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:7483018C>T	ENST00000250092.6	+	1	234	c.23C>T	c.(22-24)tCg>tTg	p.S8L	CD68_ENST00000380498.6_Missense_Mutation_p.S8L	NM_001251.2	NP_001242.2	P34810	CD68_HUMAN	CD68 molecule	8						endosome membrane|integral to membrane|lysosomal membrane|membrane fraction|plasma membrane				endometrium(1)|lung(1)|skin(1)	3						GTGCTTTTCTCGGGGGCCCTG	0.642000													15	5					0	0	0.004007	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125233401	125233401	+	RNA	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:125233401G>C	ENST00000439075.1	-	0	1344					NR_026876.1																						ATGGTATATGGTATGTCCTGC	0.403000													3	64					0	0	0.004672	0	0
ZBTB3	79842	broad.mit.edu	37	11	62521497	62521497	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:62521497G>A	ENST00000394807.3	-	1	163	c.38C>T	c.(37-39)tCg>tTg	p.S13L		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						CTTGCCAGGCGATGCCTCTAC	0.597000													9	56					0	0	0.008291	0	0
MYH15	22989	broad.mit.edu	37	3	108179195	108179195	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:108179195C>G	ENST00000273353.3	-	18	2000	c.1944G>C	c.(1942-1944)aaG>aaC	p.K648N	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	648	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TCTTTCGTTTCTTCTCCCCAA	0.328000													3	15					0	0	0.004672	0	0
CDH16	1014	broad.mit.edu	37	16	66950200	66950200	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:66950200C>T	ENST00000299752.4	-	4	455	c.262G>A	c.(262-264)Gag>Aag	p.E88K	CDH16_ENST00000568632.1_Missense_Mutation_p.E88K|CDH16_ENST00000565796.1_Missense_Mutation_p.E88K|CDH16_ENST00000570262.1_Intron|CDH16_ENST00000394055.3_Missense_Mutation_p.E88K	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	88	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCTGCCTGCTCCTCTCGGTCC	0.622000													10	54					0	0	0.008291	0	0
TMOD2	29767	broad.mit.edu	37	15	52075011	52075011	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:52075011G>C	ENST00000249700.4	+	7	939	c.718G>C	c.(718-720)Gac>Cac	p.D240H	TMOD2_ENST00000435126.2_Intron|TMOD2_ENST00000539962.2_Missense_Mutation_p.D196H	NM_001142885.1|NM_014548.3	NP_001136357.1|NP_055363.1	Q9NZR1	TMOD2_HUMAN	tropomodulin 2 (neuronal)	240					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16				all cancers(107;0.00435)		TCGCAGCAATGACCCTGTGGC	0.393000													4	121					0	0	0.009096	0	0
ROCK1	6093	broad.mit.edu	37	18	18629788	18629788	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:18629788C>T	ENST00000399799.2	-	3	1169	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1		Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TTCACTACTTCATAATCTTCA	0.274000													11	15					0	0	0.001855	0	0
SLC32A1	140679	broad.mit.edu	37	20	37357240	37357240	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:37357240C>G	ENST00000217420.1	+	2	1799	c.1536C>G	c.(1534-1536)ctC>ctG	p.L512L		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	512					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGCACTCCCTCGAGGGCCTCA	0.667000													3	29					0	0	0.004672	0	0
CRB1	23418	broad.mit.edu	37	1	197411332	197411332	+	Silent	SNP	G	G	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:197411332G>T	ENST00000367400.3	+	11	4050	c.3915G>T	c.(3913-3915)ccG>ccT	p.P1305P	CRB1_ENST00000367397.1_3'UTR|CRB1_ENST00000535699.1_Silent_p.P1281P|CRB1_ENST00000367399.2_Silent_p.P1193P|CRB1_ENST00000538660.1_Silent_p.P769P|RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000544212.1_Silent_p.P786P	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1305	EGF-like 19; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCTCTGATCCGTGTGTCAATG	0.493000													41	164					1.96642e-18	2.13891e-18	0.006999	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274343	39274343	+	Silent	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:39274343A>G	ENST00000391413.2	-	1	263	c.225T>C	c.(223-225)tgT>tgC	p.C75C		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	75	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCTGGGGCGACAGCAGCTGG	0.657000													4	82					0	0	0.001168	0	0
S1PR1	1901	broad.mit.edu	37	1	101705115	101705115	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:101705115C>G	ENST00000305352.6	+	2	950	c.575C>G	c.(574-576)tCc>tGc	p.S192C		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	192					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						TCCAGCTGCTCCACCGTGCTG	0.567000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	76					0	0	0.003271	0	0
ASB18	401036	broad.mit.edu	37	2	237103689	237103689	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:237103689C>T	ENST00000330842.6	-	5	1234	c.1140G>A	c.(1138-1140)ccG>ccA	p.P380P	AC079135.1_ENST00000415226.1_RNA|ASB18_ENST00000409749.3_Silent_p.P409P|AC079135.1_ENST00000483218.1_RNA			Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box containing 18	409					intracellular signal transduction					large_intestine(1)|lung(3)|ovary(1)|prostate(1)	6		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		ACTGGTAGAACGGCTTGTGCA	0.542000													7	24					0	0	0.001984	0	0
RFTN2	130132	broad.mit.edu	37	2	198508990	198508990	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:198508990C>G	ENST00000295049.4	-	3	866	c.330G>C	c.(328-330)aaG>aaC	p.K110N		NM_144629.2	NP_653230.2	Q52LD8	RFTN2_HUMAN	raftlin family member 2							plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(13)|urinary_tract(3)	30						CTGCCGAATTCTTTGGGCTGT	0.463000													9	29					0	0	0.004482	0	0
TBC1D1	23216	broad.mit.edu	37	4	38022296	38022296	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:38022296C>T	ENST00000261439.4	+	5	1412	c.1057C>T	c.(1057-1059)Cag>Tag	p.Q353*	TBC1D1_ENST00000508802.1_Nonsense_Mutation_p.Q353*	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	353	PID.					nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TTACGTGTTTCAGTGCACAAA	0.478000													36	130					0	0	0.003755	0	0
FMN1	342184	broad.mit.edu	37	15	33358805	33358805	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:33358805G>C	ENST00000334528.9	-	1	1280	c.1281C>G	c.(1279-1281)ctC>ctG	p.L427L	FMN1_ENST00000559047.1_Intron|FMN1_ENST00000559150.1_Intron|FMN1_ENST00000561249.1_Intron|FMN1_ENST00000558197.1_Silent_p.L427L	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	177	Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TCTTGCGCTTGAGAGCTTCCA	0.532000													6	21					0	0	0.001984	0	0
INTS3	65123	broad.mit.edu	37	1	153723691	153723691	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:153723691C>T	ENST00000456435.1	+	7	1273	c.87C>T	c.(85-87)ttC>ttT	p.F29F	RP11-216N14.9_ENST00000434575.1_RNA|INTS3_ENST00000435409.2_Silent_p.F235F|INTS3_ENST00000512605.1_Silent_p.F29F|RP11-216N14.8_ENST00000453778.1_RNA|INTS3_ENST00000318967.2_Silent_p.F235F|INTS3_ENST00000476843.1_3'UTR			Q68E01	INT3_HUMAN	integrator complex subunit 3	236	Ala/Gly-rich.				DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAGTAGACTTCTGCATCTCAC	0.542000													7	72					0	0	0.001984	0	0
FAM63B	54629	broad.mit.edu	37	15	59123984	59123984	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:59123984G>C	ENST00000559228.1	+	6	1319	c.1237G>C	c.(1237-1239)Gag>Cag	p.E413Q	FAM63B_ENST00000450403.2_Missense_Mutation_p.E413Q			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	413										central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CTTTGTAGCTGAGCAGTTTCT	0.338000													5	54					0	0	0.000602	0	0
MAD1L1	8379	broad.mit.edu	37	7	2269702	2269702	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:2269702G>A	ENST00000406869.1	-	3	624	c.67C>T	c.(67-69)Cag>Tag	p.Q23*	MAD1L1_ENST00000402746.1_Intron|MAD1L1_ENST00000399654.2_Nonsense_Mutation_p.Q23*|MAD1L1_ENST00000265854.7_Nonsense_Mutation_p.Q23*			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	23					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCCACACGCTGAGAGATGAAG	0.532000													6	12					0	0	0.001168	0	0
ZNF273	10793	broad.mit.edu	37	7	64363703	64363703	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:64363703C>T	ENST00000476120.1	+	1	79	c.8C>T	c.(7-9)tCt>tTt	p.S3F	ZNF273_ENST00000545510.1_5'UTR|ZNF273_ENST00000527278.1_Intron|ZNF273_ENST00000319636.5_5'UTR	NM_021148.2	NP_066971.2	Q14593	ZN273_HUMAN	zinc finger protein 273	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TCTATGTCCTCTGCTCCTAGA	0.592000													13	37					0	0	0.013537	0	0
MORN3	283385	broad.mit.edu	37	12	122091125	122091125	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:122091125C>T	ENST00000355329.3	-	4	674	c.504G>A	c.(502-504)atG>atA	p.M168I		NM_173855.4	NP_776254.3	Q6PF18	MORN3_HUMAN	MORN repeat containing 3	168										breast(2)|large_intestine(1)|lung(4)|skin(1)|stomach(1)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)		CCCCGTTCTTCATGCCTCTCT	0.587000													9	44					0	0	0.006214	0	0
CLCN1	1180	broad.mit.edu	37	7	143039095	143039095	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:143039095G>C	ENST00000343257.2	+	15	1743	c.1656G>C	c.(1654-1656)caG>caC	p.Q552H		NM_000083.2	NP_000074	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	552			Q -> R (in THD, MCR and in myotonia levior).		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity	p.Q552Q(1)		breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TAACGGGTCAGATTGCTCACA	0.532000													23	45					0	0	0.003330	0	0
ZNF223	7766	broad.mit.edu	37	19	44571040	44571040	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:44571040C>T	ENST00000591793.1	+	7	1472	c.1389C>T	c.(1387-1389)ttC>ttT	p.F463F	ZNF223_ENST00000434772.3_Silent_p.F353F			Q9UK11	ZN223_HUMAN	zinc finger protein 223	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				GGAAGAGCTTCAGACGGTCCT	0.433000													17	140					0	0	0.006122	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135098627	135098627	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:135098627G>A	ENST00000368563.2	-	13	2342	c.1986C>T	c.(1984-1986)aaC>aaT	p.N662N	TUBGCP2_ENST00000543663.1_Silent_p.N690N|TUBGCP2_ENST00000252936.3_Silent_p.N662N|TUBGCP2_ENST00000417178.2_Silent_p.N532N|TUBGCP2_ENST00000368562.1_Silent_p.N255N	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	662					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		TGGCGGTTTTGTTGCTGATCC	0.607000													9	52					0	0	0.004482	0	0
OR6A2	8590	broad.mit.edu	37	11	6816130	6816130	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:6816130G>C	ENST00000332601.3	-	1	998	c.810C>G	c.(808-810)ctC>ctG	p.L270L		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAAAAGCTGAGAGTGCCTTTG	0.463000													12	67					0	0	0.010729	0	0
EFTUD2	9343	broad.mit.edu	37	17	42936546	42936546	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:42936546C>G	ENST00000426333.2	-	19	2161	c.1864G>C	c.(1864-1866)Gag>Cag	p.E622Q	EFTUD2_ENST00000591382.1_Missense_Mutation_p.E622Q|EFTUD2_ENST00000592576.1_Missense_Mutation_p.E612Q|EFTUD2_ENST00000402521.3_Missense_Mutation_p.E587Q	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	622						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CCAGACTCCTCCACCTGAAAC	0.502000													8	73					0	0	0.003080	0	0
LMOD1	25802	broad.mit.edu	37	1	201915321	201915321	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:201915321G>A	ENST00000367288.4	-	1	394	c.148C>T	c.(148-150)Cgg>Tgg	p.R50W		NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	50					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TTTCTCTGCCGCAGCCCCACG	0.587000													13	54					0	0	0.013537	0	0
ADAM23	8745	broad.mit.edu	37	2	207310119	207310119	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:207310119C>T	ENST00000264377.3	+	2	631	c.303C>T	c.(301-303)atC>atT	p.I101I	ADAM23_ENST00000374416.1_Silent_p.I101I|ADAM23_ENST00000374415.3_Silent_p.I101I	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	101					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		GCAGTAATATCAGTTACAGCA	0.413000													5	92					0	0	0.000602	0	0
C2orf16	84226	broad.mit.edu	37	2	27801569	27801569	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:27801569G>C	ENST00000408964.2	+	1	2181	c.2130G>C	c.(2128-2130)caG>caC	p.Q710H		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	710										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					ACGTGTGTCAGAATAGGGACT	0.418000													23	48					0	0	0.012319	0	0
SYT15	83849	broad.mit.edu	37	10	46967671	46967671	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:46967671C>T	ENST00000374323.4	-	3	1152	c.565G>A	c.(565-567)Gag>Aag	p.E189K	SYT15_ENST00000374321.4_Missense_Mutation_p.E136K|SYT15_ENST00000503753.1_Missense_Mutation_p.E136K|SYT15_ENST00000374325.3_Missense_Mutation_p.E136K			Q9BQS2	SYT15_HUMAN	synaptotagmin XV		C2 1.					integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CTTTTGTCCTCCGGGAACTTG	0.617000													13	132					0	0	0.002450	0	0
SNRNP48	154007	broad.mit.edu	37	6	7602962	7602962	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:7602962G>C	ENST00000342415.5	+	6	761	c.702G>C	c.(700-702)aaG>aaC	p.K234N		NM_152551.3	NP_689764.3	Q6IEG0	SNR48_HUMAN	small nuclear ribonucleoprotein 48kDa (U11/U12)	234					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding			kidney(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						ACATAACCAAGAAATCATATA	0.338000													9	27					0	0	0.006214	0	0
TES	26136	broad.mit.edu	37	7	115890320	115890320	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:115890320G>A	ENST00000358204.4	+	4	687	c.472G>A	c.(472-474)Gac>Aac	p.D158N	AC002066.1_ENST00000446355.2_RNA|TES_ENST00000393481.2_Missense_Mutation_p.D149N|TES_ENST00000537767.1_Intron|AC073130.3_ENST00000444244.1_RNA	NM_015641.3	NP_056456.1	Q9UGI8	TES_HUMAN	testis derived transcript (3 LIM domains)	158	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			CCCTGCACATGACCAGGACCC	0.532000													9	53					0	0	0.004482	0	0
FCRLB	127943	broad.mit.edu	37	1	161697035	161697035	+	Splice_Site	SNP	A	A	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:161697035A>T	ENST00000367948.2	+	8	1080		c.e8-1		FCRLB_ENST00000367945.1_Splice_Site|FCRLB_ENST00000336830.5_Splice_Site|FCRLB_ENST00000367944.3_Splice_Site|FCRLB_ENST00000495397.1_Splice_Site|FCRLB_ENST00000367946.3_Splice_Site|FCRLB_ENST00000392158.1_Splice_Site			Q6BAA4	FCRLB_HUMAN	Fc receptor-like B							endoplasmic reticulum				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|skin(1)	17	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ATGCATTCACAGGTTCTCCCC	0.682000													3	17					0	0	0.009096	0	0
GNAO1	2775	broad.mit.edu	37	16	56385394	56385394	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:56385394C>G	ENST00000262493.6	+	7	1668	c.822C>G	c.(820-822)ctC>ctG	p.L274L		NM_020988.2	NP_066268.1	P09471	GNAO_HUMAN	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	274					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)	17		all_neural(199;0.159)				AGAAAGATCTCTTTGGCGAGA	0.498000													5	58					0	0	0.001168	0	0
SPECC1L	23384	broad.mit.edu	37	22	24759250	24759250	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:24759250C>A	ENST00000314328.9	+	12	3050	c.2765C>A	c.(2764-2766)tCa>tAa	p.S922*	SPECC1L-ADORA2A_ENST00000358654.2_3'UTR|SPECC1L_ENST00000437398.1_Nonsense_Mutation_p.S922*|SPECC1L_ENST00000541492.1_Nonsense_Mutation_p.S922*	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	922					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						AGAACATCTTCAGCCAGCCGG	0.413000													16	16					1.5739e-10	1.69497e-10	0.004007	1	0
SMR3A	26952	broad.mit.edu	37	4	71232491	71232491	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:71232491G>C	ENST00000226460.4	+	3	281	c.185G>C	c.(184-186)aGa>aCa	p.R62T		NM_012390.3	NP_036522.3	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3A	62	Pro-rich.					extracellular region				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)	15		all_hematologic(202;0.196)				GGTCCAGGGAGATTTCCACCA	0.547000													5	97					0	0	0.000602	0	0
TLK2	11011	broad.mit.edu	37	17	60683562	60683562	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:60683562C>T	ENST00000582809.1	+	21	2187	c.1484C>T	c.(1483-1485)tCg>tTg	p.S495L	TLK2_ENST00000326270.9_Missense_Mutation_p.S666L|TLK2_ENST00000343388.7_Missense_Mutation_p.S612L|TLK2_ENST00000346027.5_Missense_Mutation_p.S644L|TLK2_ENST00000542523.1_Missense_Mutation_p.S612L			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	666	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						GATGTGTGGTCGGTGGGTGTG	0.398000													3	36					0	0	0.000602	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846001	72846001	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:72846001G>A	ENST00000293190.5	-	7	1709	c.1563C>T	c.(1561-1563)gaC>gaT	p.D521D	GRIN2C_ENST00000347612.4_Silent_p.D521D	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	521					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GTACAGAGAAGTCTACGATCT	0.617000													28	72					0	0	0.006320	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156619	26156619	+	Translation_Start_Site	SNP	A	A	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:26156619A>T	ENST00000304218.3	+	1	61	c.1A>T	c.(1-3)Atg>Ttg	p.M1L		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	1					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						TGCCTTCAACATGTCCGAGAC	0.672000													5	197					0	0	0.001168	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84531751	84531751	+	RNA	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:84531751C>G	ENST00000527857.1	+	0	1773					NR_026851.1																						ACATCTCACTCAGGTCCAGTC	0.532000													7	26					0	0	0.001984	0	0
FBXO43	286151	broad.mit.edu	37	8	101149855	101149855	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:101149855G>C	ENST00000428847.2	-	3	1928	c.1612C>G	c.(1612-1614)Caa>Gaa	p.Q538E		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	538	F-box.				meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TTTTTATCTTGAACAACAATT	0.299000													15	28					0	0	0.004007	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729403	37729403	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:37729403C>G	ENST00000330843.4	-	4	2929	c.2917G>C	c.(2917-2919)Gat>Cat	p.D973H	RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	973					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCAACCTGATCTATTCTTTCA	0.458000													10	67					0	0	0.006214	0	0
UNC119	9094	broad.mit.edu	37	17	26879509	26879509	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:26879509G>A	ENST00000301032.4	-	1	140	c.67C>T	c.(67-69)Cag>Tag	p.Q23*	UNC119_ENST00000335765.4_Nonsense_Mutation_p.Q23*	NM_054035.2	NP_473376.1	Q13432	U119A_HUMAN	unc-119 homolog (C. elegans)	23					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction				breast(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	7	Lung NSC(42;0.00431)					GCCACGCTCTGGCCCGAGGGC	0.751000													3	8					0	0	0.004672	0	0
ZNF696	79943	broad.mit.edu	37	8	144377992	144377992	+	Silent	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:144377992C>A	ENST00000330143.3	+	3	556	c.147C>A	c.(145-147)gcC>gcA	p.A49A		NM_030895.2	NP_112157.2	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CGGAGCCTGCCGCAGAGGCAG	0.672000													2	3					0.004672	0.00485083	0.004672	1	0
ADAMTS3	9508	broad.mit.edu	37	4	73169687	73169687	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:73169687C>T	ENST00000286657.4	-	17	2407	c.2371G>A	c.(2371-2373)Gac>Aac	p.D791N		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	791	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTTCAATGTCATCTTCAATG	0.423000													21	97					0	0	0.008871	0	0
RELN	5649	broad.mit.edu	37	7	103322663	103322663	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:103322663C>T	ENST00000424685.2	-	11	1348	c.1189G>A	c.(1189-1191)Gaa>Aaa	p.E397K	RELN_ENST00000343529.5_Missense_Mutation_p.E397K|RELN_ENST00000428762.1_Missense_Mutation_p.E397K			P78509	RELN_HUMAN	reelin	397					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCGCTGCCTTCATTTCCATGG	0.458000													4	88					0	0	0.001984	0	0
GLI3	2737	broad.mit.edu	37	7	42187951	42187951	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:42187951C>T	ENST00000395925.3	-	3	325	c.241G>A	c.(241-243)Gag>Aag	p.E81K	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	81					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GAGGCCCTCTCGTCACTCGAT	0.552000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				6	36					0	0	0.001168	0	0
DHRS9	10170	broad.mit.edu	37	2	169939948	169939948	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:169939948C>T	ENST00000327239.4	+	6	1927	c.423C>T	c.(421-423)ctC>ctT	p.L141L	DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000357546.2_Silent_p.L141L|DHRS9_ENST00000602501.1_Silent_p.L141L|DHRS9_ENST00000436483.2_Silent_p.L141L|DHRS9_ENST00000432060.2_Silent_p.L201L|DHRS9_ENST00000428522.1_Silent_p.L141L|DHRS9_ENST00000412271.1_Silent_p.L141L	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	141					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity	p.L141L(1)		breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						TGTTTGGACTCATCAGTGTGA	0.488000													11	73					0	0	0.008291	0	0
SLC22A12	116085	broad.mit.edu	37	11	64359356	64359356	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:64359356G>A	ENST00000377574.1	+	1	1075	c.328G>A	c.(328-330)Gag>Aag	p.E110K	SLC22A12_ENST00000377572.1_Missense_Mutation_p.E110K|SLC22A12_ENST00000473690.1_5'UTR|SLC22A12_ENST00000377567.2_Missense_Mutation_p.E110K|SLC22A12_ENST00000336464.7_Missense_Mutation_p.E110K	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	110					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						CAGCTGGAGCGAGGCCGACAC	0.677000													6	37					0	0	0.001168	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730228	37730228	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:37730228C>G	ENST00000330843.4	-	4	2104	c.2092G>C	c.(2092-2094)Gaa>Caa	p.E698Q	RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	698					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CGCCCTGTTTCAGGCTGCTCT	0.527000													11	43					0	0	0.010729	0	0
PTPRC	5788	broad.mit.edu	37	1	198711037	198711037	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:198711037C>T	ENST00000367376.2	+	24	2608	c.2437C>T	c.(2437-2439)Cag>Tag	p.Q813*	PTPRC_ENST00000442510.2_Nonsense_Mutation_p.Q815*|PTPRC_ENST00000352140.3_Nonsense_Mutation_p.Q765*|PTPRC_ENST00000594404.1_Nonsense_Mutation_p.Q652*|PTPRC_ENST00000348564.6_Nonsense_Mutation_p.Q654*	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	813	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GACTCACATTCAGTTCACCAG	0.413000													3	32					0	0	0.004672	0	0
MRPL52	122704	broad.mit.edu	37	14	23299420	23299420	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:23299420C>T	ENST00000355151.5	+	3	144	c.114C>T	c.(112-114)tcC>tcT	p.S38S	MRPL52_ENST00000553711.1_5'UTR|MRPL52_ENST00000557221.1_5'UTR|MRPL52_ENST00000556840.1_5'UTR|MRPL52_ENST00000397505.2_Silent_p.S38S|MRPL52_ENST00000311892.6_5'UTR|MRPL52_ENST00000397496.3_Silent_p.S37S|MRPL52_ENST00000432849.3_Silent_p.S37S|MRPL52_ENST00000555345.1_5'UTR|MRPL52_ENST00000461594.1_3'UTR|MRPL52_ENST00000555536.1_5'UTR	NM_178336.2|NM_180982.2|NM_181306.2	NP_848026.1|NP_851313.1|NP_851823.1	Q86TS9	RM52_HUMAN	mitochondrial ribosomal protein L52	38					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome					all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CCAACCCCTCCGGCTACGGGC	0.597000													27	94					0	0	0.007291	0	0
GUF1	60558	broad.mit.edu	37	4	44680684	44680684	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:44680684C>T	ENST00000281543.5	+	1	239	c.45C>T	c.(43-45)ctC>ctT	p.L15L	GUF1_ENST00000506793.1_Intron	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)	15					translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						CACGCGCTCTCGCGCCACGAG	0.736000													3	9					0	0	0.004672	0	0
INSR	3643	broad.mit.edu	37	19	7125313	7125313	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:7125313C>G	ENST00000341500.5	-	16	3242	c.3203G>C	c.(3202-3204)gGc>gCc	p.G1068A	INSR_ENST00000302850.5_Missense_Mutation_p.G1080A	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1080	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCAGGTGAAGCCCTTCATGAC	0.607000													5	43					0	0	0.000602	0	0
SETD2	29072	broad.mit.edu	37	3	47162371	47162371	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:47162371G>A	ENST00000409792.3	-	3	3797	c.3755C>T	c.(3754-3756)tCa>tTa	p.S1252L		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GAGCTCTTCTGATGAGTGCAA	0.453000			"""N, F, S, Mis"""		clear cell renal carcinoma								11	86					0	0	0.008291	0	0
NES	10763	broad.mit.edu	37	1	156640874	156640874	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:156640874C>T	ENST00000368223.3	-	4	3238	c.3106G>A	c.(3106-3108)Gag>Aag	p.E1036K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1036	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGAGGCCCTCAGCCCCTCCC	0.667000													18	165					0	0	0.010504	0	0
ERBB3	2065	broad.mit.edu	37	12	56478817	56478817	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:56478817G>C	ENST00000267101.3	+	3	713	c.273G>C	c.(271-273)atG>atC	p.M91I	ERBB3_ENST00000415288.2_Missense_Mutation_p.M32I|ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000411731.2_Missense_Mutation_p.M91I	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	91					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.M91I(1)		central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TCGTGGCCATGAATGAATTCT	0.473000													33	83					0	0	0.012213	0	0
PSMD11	5717	broad.mit.edu	37	17	30807593	30807593	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:30807593C>T	ENST00000261712.3	+	13	1476	c.1213C>T	c.(1213-1215)Cag>Tag	p.Q405*	PSMD11_ENST00000457654.2_Nonsense_Mutation_p.Q405*	NM_001270482.1|NM_002815.3	NP_001257411.1|NP_002806.2	O00231	PSD11_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	405					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			GGAAACAATTCAGAACATGAG	0.483000													4	78					0	0	0.009096	0	0
EDC3	80153	broad.mit.edu	37	15	74927826	74927826	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:74927826G>C	ENST00000315127.4	-	6	1297	c.1116C>G	c.(1114-1116)gtC>gtG	p.V372V	EDC3_ENST00000568176.1_Silent_p.V372V|EDC3_ENST00000426797.3_Silent_p.V372V	NM_001142444.1|NM_025083.3	NP_001135916.1|NP_079359.2	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	372	YjeF N-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						CCAACATCTTGACAAAATTGG	0.522000											OREG0023287	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	79					0	0	0.013537	0	0
NTN4	59277	broad.mit.edu	37	12	96104265	96104265	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:96104265G>C	ENST00000343702.4	-	5	1582	c.1134C>G	c.(1132-1134)ttC>ttG	p.F378L	NTN4_ENST00000553059.1_Missense_Mutation_p.F378L|NTN4_ENST00000344911.4_Missense_Mutation_p.F341L|NTN4_ENST00000538383.1_Missense_Mutation_p.F341L	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	378	Laminin EGF-like 2.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GGTCACGATAGAAGCCTGGCT	0.483000													13	52					0	0	0.013537	0	0
PZP	5858	broad.mit.edu	37	12	9353646	9353646	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:9353646C>G	ENST00000261336.2	-	6	540	c.512G>C	c.(511-513)aGa>aCa	p.R171T	PZP_ENST00000381997.2_Missense_Mutation_p.R40T	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						AATTCGATTTCTTCTTGGGTT	0.438000													13	60					0	0	0.003163	0	0
PTPN21	11099	broad.mit.edu	37	14	88945434	88945434	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:88945434C>T	ENST00000556564.1	-	13	2625	c.2341G>A	c.(2341-2343)Gca>Aca	p.A781T	PTPN21_ENST00000328736.3_Missense_Mutation_p.A781T	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	781						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TGGGCCTCTGCGGTCGTGCGG	0.697000													7	45					0	0	0.001984	0	0
CACNG5	27091	broad.mit.edu	37	17	64880683	64880683	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:64880683G>A	ENST00000533854.1	+	5	712	c.475G>A	c.(475-477)Gag>Aag	p.E159K	CACNG5_ENST00000169565.3_Missense_Mutation_p.E159K|CACNG5_ENST00000307139.3_Missense_Mutation_p.E159K			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	159					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CATCAACGATGAGATGCTCAA	0.562000													10	71					0	0	0.008291	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A|SIRPB1_ENST00000381603.3_Intron|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381605.4_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													5	38					0	0	0.000602	0	0
ABRA	137735	broad.mit.edu	37	8	107782327	107782327	+	Missense_Mutation	SNP	C	C	G	rs148182297		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:107782327C>G	ENST00000311955.3	-	1	146	c.92G>C	c.(91-93)cGa>cCa	p.R31P		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	31					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CTGCCAACCTCGGGCCAAGCT	0.647000													8	83					0	0	0.008291	0	0
PHEX	5251	broad.mit.edu	37	X	22056609	22056609	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:22056609C>T	ENST00000379374.4	+	2	706	c.141C>T	c.(139-141)ctC>ctT	p.L47L	PHEX_ENST00000535894.1_5'UTR|PHEX_ENST00000537599.1_Silent_p.L47L	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	47					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						TCTTAAGTCTCCAAGCTAAAC	0.453000													40	176					0	0	0.007835	0	0
GOLGA1	2800	broad.mit.edu	37	9	127693663	127693663	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:127693663C>G	ENST00000373555.4	-	4	491	c.158G>C	c.(157-159)aGa>aCa	p.R53T		NM_002077.3	NP_002068	Q92805	GOGA1_HUMAN	golgin A1	53						Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						AAGATCTTCTCTGGAGCTGCT	0.433000													19	87					0	0	0.010504	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768941	31768941	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:31768941C>T	ENST00000240587.4	-	2	2085	c.1758G>A	c.(1756-1758)acG>acA	p.T586T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	586					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TCTGGTTTTTCGTCGGGGAGA	0.552000													21	114					0	0	0.012319	0	0
PHF3	23469	broad.mit.edu	37	6	64421841	64421841	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:64421841C>T	ENST00000262043.3	+	16	4697	c.4357C>T	c.(4357-4359)Caa>Taa	p.Q1453*	PHF3_ENST00000393387.1_Nonsense_Mutation_p.Q1453*			Q92576	PHF3_HUMAN	PHD finger protein 3	1453					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CTGGGAGAATCAACCTACTAC	0.448000													17	53					0	0	0.004990	0	0
LRRC3	81543	broad.mit.edu	37	21	45876666	45876666	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr21:45876666G>A	ENST00000291592.4	+	2	456	c.139G>A	c.(139-141)Gct>Act	p.A47T		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	47	LRRNT.					integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		AGGGGCTGTGGCTGTCTTCTG	0.667000													7	34					0	0	0.001984	0	0
IL12RB2	3595	broad.mit.edu	37	1	67792462	67792462	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:67792462G>A	ENST00000262345.1	+	4	1049	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K	IL12RB2_ENST00000371000.1_Missense_Mutation_p.E137K|IL12RB2_ENST00000544434.1_Missense_Mutation_p.E137K|IL12RB2_ENST00000541374.1_Missense_Mutation_p.E137K	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	137	Fibronectin type-III 1.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						ACAGAAGGGAGAACAGGGGAC	0.428000													10	67					0	0	0.008291	0	0
PGM2	55276	broad.mit.edu	37	4	37848724	37848724	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:37848724C>T	ENST00000381967.4	+	9	1280	c.1180C>T	c.(1180-1182)Cat>Tat	p.H394Y	PGM2_ENST00000537241.1_Missense_Mutation_p.H234Y|PGM2_ENST00000544359.1_Missense_Mutation_p.H255Y	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	394					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						GGAAGGTTTTCATTTTGAGGT	0.448000													28	79					0	0	0.007291	0	0
FRMD8	83786	broad.mit.edu	37	11	65168229	65168229	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:65168229C>T	ENST00000317568.5	+	9	1125	c.962C>T	c.(961-963)tCg>tTg	p.S321L	FRMD8_ENST00000416776.2_Missense_Mutation_p.S287L|FRMD8_ENST00000355991.5_Missense_Mutation_p.S265L	NM_031904.3	NP_114110.1	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	321	FERM.					cytoskeleton	binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|urinary_tract(1)	17						CAGGAGCTGTCGTGGGACCAC	0.647000													8	44					0	0	0.003080	0	0
EID2	163126	broad.mit.edu	37	19	40030401	40030401	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:40030401C>T	ENST00000390658.2	-	1	469	c.319G>A	c.(319-321)Gag>Aag	p.E107K		NM_153232.3	NP_694964.3	Q8N6I1	EID2_HUMAN	EP300 interacting inhibitor of differentiation 2	107	Ala-rich.				cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding			large_intestine(2)|lung(1)|urinary_tract(1)	4	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CGGGCGACCTCCGCCATCCGG	0.756000													6	90					0	0	0.001168	0	0
RNF17	56163	broad.mit.edu	37	13	25428222	25428222	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:25428222G>C	ENST00000255324.5	+	25	3602	c.3550G>C	c.(3550-3552)Gag>Cag	p.E1184Q	RNF17_ENST00000339524.3_Missense_Mutation_p.E236Q|RNF17_ENST00000381921.1_Missense_Mutation_p.E1184Q	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1184					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GAACGTATTTGAGGCAACAGT	0.393000													7	38					0	0	0.001984	0	0
TMOD2	29767	broad.mit.edu	37	15	52074980	52074980	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:52074980G>A	ENST00000249700.4	+	7	908	c.687G>A	c.(685-687)aaG>aaA	p.K229K	TMOD2_ENST00000435126.2_Intron|TMOD2_ENST00000539962.2_Silent_p.K185K	NM_001142885.1|NM_014548.3	NP_001136357.1|NP_055363.1	Q9NZR1	TMOD2_HUMAN	tropomodulin 2 (neuronal)	229					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16				all cancers(107;0.00435)		CTCACGTGAAGAAGTTCAGCC	0.433000													5	159					0	0	0.000602	0	0
KIAA1009	22832	broad.mit.edu	37	6	84925148	84925148	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:84925148C>T	ENST00000403245.3	-	5	469	c.355G>A	c.(355-357)Gga>Aga	p.G119R	KIAA1009_ENST00000257766.4_Missense_Mutation_p.G43R	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	119					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		AATCCCACTCCGAGACTACTA	0.333000													5	18					0	0	0.001984	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65242076	65242076	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:65242076C>G	ENST00000380230.3	+	14	1395	c.1366C>G	c.(1366-1368)Cag>Gag	p.Q456E	ANKDD1A_ENST00000357698.3_Missense_Mutation_p.Q424E|ANKDD1A_ENST00000395723.1_Missense_Mutation_p.Q333E|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.Q456E	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	456	Death.				signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						CAGGAGCTATCAGGAGCACGG	0.622000													3	79					0	0	0.004672	0	0
C6orf15	29113	broad.mit.edu	37	6	31079483	31079483	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:31079483C>T	ENST00000259870.3	-	2	656	c.653G>A	c.(652-654)tGg>tAg	p.W218*		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	218										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						TCCACCTCCCCAGGACACACT	0.612000													8	98					0	0	0.004482	0	0
GUCA1A	2978	broad.mit.edu	37	6	42146056	42146056	+	Silent	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:42146056C>A	ENST00000394237.1	+	4	1216	c.240C>A	c.(238-240)ctC>ctA	p.L80L	GUCA1A_ENST00000053469.4_Silent_p.L80L|GUCA1A_ENST00000541991.1_Silent_p.L80L|GUCA1A_ENST00000372958.1_Silent_p.L80L			P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	80	EF-hand 2.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	7	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGCAGCGCTCAGCTTGGTCC	0.622000													28	111					2.12542e-12	2.30033e-12	0.006320	1	0
TLN2	83660	broad.mit.edu	37	15	62944237	62944237	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:62944237C>G	ENST00000561311.1	+	5	498	c.268C>G	c.(268-270)Cag>Gag	p.Q90E	TLN2_ENST00000306829.6_Missense_Mutation_p.Q90E			Q9Y4G6	TLN2_HUMAN	talin 2	90	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						ACAGAGACCTCAGAAAATCCG	0.403000													10	36					0	0	0.006214	0	0
ZNF496	84838	broad.mit.edu	37	1	247464049	247464049	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:247464049C>T	ENST00000294753.4	-	9	2000	c.1536G>A	c.(1534-1536)ccG>ccA	p.P512P	ZNF496_ENST00000462139.1_5'UTR|ZNF496_ENST00000366498.2_Silent_p.P548P	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	512					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CGTTTTCCAGCGGCTCTTTGG	0.642000													4	110					0	0	0.009096	0	0
STAT1	6772	broad.mit.edu	37	2	191839600	191839600	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:191839600C>G	ENST00000361099.3	-	24	2581	c.2194G>C	c.(2194-2196)Gac>Cac	p.D732H	STAT1_ENST00000540176.1_3'UTR|STAT1_ENST00000409465.1_Missense_Mutation_p.D732H	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	732					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GACACCTCGTCAAACTCCTCA	0.493000													7	40					0	0	0.001984	0	0
ZFP36L1	677	broad.mit.edu	37	14	69257106	69257106	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:69257106G>C	ENST00000439696.2	-	2	462	c.161C>G	c.(160-162)tCa>tGa	p.S54*	ZFP36L1_ENST00000555997.1_3'UTR|ZFP36L1_ENST00000336440.3_Nonsense_Mutation_p.S54*	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	54					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CAGGGTGACTGAGTGCCTCCG	0.632000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	22					0	0	0.008291	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125367461	125367461	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:125367461C>T	ENST00000431078.1	+	12	2201	c.1837C>T	c.(1837-1839)Cca>Tca	p.P613S		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	613	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGCAGCGGCCCACTGGGACC	0.522000													5	66					0	0	0.000602	0	0
FXR1	8087	broad.mit.edu	37	3	180693957	180693957	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:180693957C>T	ENST00000357559.4	+	17	2127	c.1743C>T	c.(1741-1743)aaC>aaT	p.N581N	FXR1_ENST00000491062.1_3'UTR|FXR1_ENST00000445140.2_3'UTR|FXR1_ENST00000305586.7_Silent_p.N496N|FXR1_ENST00000468861.1_3'UTR|FXR1_ENST00000480918.1_Silent_p.N568N	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	581					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			AGGCAATAAACGGCCCAACTA	0.393000													18	44					0	0	0.004990	0	0
PTPRB	5787	broad.mit.edu	37	12	70970178	70970178	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:70970178G>A	ENST00000334414.6	-	11	2870	c.2826C>T	c.(2824-2826)ttC>ttT	p.F942F	PTPRB_ENST00000550857.1_Silent_p.F634F|PTPRB_ENST00000261266.5_Silent_p.F724F|PTPRB_ENST00000550358.1_Intron|PTPRB_ENST00000538708.1_Silent_p.F724F|PTPRB_ENST00000551525.1_Silent_p.F941F|PTPRB_ENST00000451516.2_Silent_p.F634F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	724	Fibronectin type-III 11.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTCTTGGCTGAAGGAGTGAT	0.512000													4	20					0	0	0.000602	0	0
NAP1L1	4673	broad.mit.edu	37	12	76447602	76447602	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:76447602C>G	ENST00000261182.8	-	9	1204	c.718G>C	c.(718-720)Gat>Cat	p.D240H	NAP1L1_ENST00000547773.1_Missense_Mutation_p.D177H|NAP1L1_ENST00000544816.1_Missense_Mutation_p.D57H|NAP1L1_ENST00000542344.1_Missense_Mutation_p.D198H|NAP1L1_ENST00000548044.1_Missense_Mutation_p.D199H|NAP1L1_ENST00000552342.1_Missense_Mutation_p.D251H|NAP1L1_ENST00000431879.3_Missense_Mutation_p.D172H|NAP1L1_ENST00000393263.3_Missense_Mutation_p.D240H|NAP1L1_ENST00000549596.1_Missense_Mutation_p.D240H|NAP1L1_ENST00000535020.2_Missense_Mutation_p.D240H|NAP1L1_ENST00000547993.1_Missense_Mutation_p.D57H	NM_004537.4|NM_139207.2	NP_004528.1|NP_631946.1	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	240					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	9		Colorectal(145;0.09)				TCAGAATCATCTGGTTCTGAC	0.348000													17	33					0	0	0.004990	0	0
INPPL1	3636	broad.mit.edu	37	11	71946359	71946359	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:71946359C>G	ENST00000298229.2	+	23	2727	c.2523C>G	c.(2521-2523)ctC>ctG	p.L841L	INPPL1_ENST00000538751.1_Silent_p.L599L|INPPL1_ENST00000541756.1_Silent_p.L599L	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	841					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TGGTTGCACTCAAATCCATGA	0.572000													20	99					0	0	0.008871	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632625	205632625	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:205632625C>T	ENST00000367145.3	-	3	589	c.294G>A	c.(292-294)ctG>ctA	p.L98L		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	98					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			GAAAGAGGCTCAGCAGGATGC	0.677000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								6	30					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179413733	179413733	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:179413733C>T	ENST00000589042.1	-	339	92844	c.92620G>A	c.(92620-92622)Gag>Aag	p.E30874K	TTN_ENST00000359218.5_Missense_Mutation_p.E21934K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E22001K|TTN_ENST00000591111.1_Missense_Mutation_p.E29233K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E21809K|TTN_ENST00000342992.6_Missense_Mutation_p.E28306K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29233	Fibronectin type-III 125.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACATGCCTCTGCATTCACC	0.423000													18	83					0	0	0.007413	0	0
ANKRD28	23243	broad.mit.edu	37	3	15726759	15726759	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:15726759G>A	ENST00000399451.2	-	21	2640	c.2273C>T	c.(2272-2274)aCg>aTg	p.T758M	ANKRD28_ENST00000383777.1_Missense_Mutation_p.T791M|ANKRD28_ENST00000497037.1_5'UTR	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	758						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						GTGAAGTGCCGTATATCCATG	0.423000													4	162					0	0	0.009096	0	0
CHMP2A	27243	broad.mit.edu	37	19	59063309	59063309	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:59063309C>G	ENST00000600118.1	-	4	930	c.505G>C	c.(505-507)Gat>Cat	p.D169H	CHMP2A_ENST00000312547.2_Missense_Mutation_p.D169H|CHMP2A_ENST00000601220.1_Missense_Mutation_p.D169H			O43633	CHM2A_HUMAN	charged multivesicular body protein 2A	169	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	7		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCAGCTCATCCAGAACCTGG	0.577000													21	44					0	0	0.008871	0	0
CDK14	5218	broad.mit.edu	37	7	90741917	90741917	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:90741917G>C	ENST00000406263.1	+	12	1519	c.1077G>C	c.(1075-1077)aaG>aaC	p.K359N	CDK14_ENST00000265741.3_Missense_Mutation_p.K387N|CDK14_ENST00000380050.3_Missense_Mutation_p.K405N|CDK14_ENST00000436577.2_Missense_Mutation_p.K276N			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	405	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						GTTCCCCAAAGAACAGACTGT	0.502000													4	112					0	0	0.009096	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135721778	135721778	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:135721778C>G	ENST00000264977.3	+	2	2055	c.1438C>G	c.(1438-1440)Cta>Gta	p.L480V	PPP2R3A_ENST00000490467.1_Intron	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	480					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						ATTTGTTAATCTACCTAAGGA	0.338000													11	58					0	0	0.008291	0	0
UBE4B	10277	broad.mit.edu	37	1	10186932	10186932	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:10186932C>G	ENST00000377157.3	+	10	1961	c.900C>G	c.(898-900)ctC>ctG	p.L300L	UBE4B_ENST00000343090.6_Silent_p.L545L|UBE4B_ENST00000253251.8_Silent_p.L416L|UBE4B_ENST00000475795.1_3'UTR	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	545					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AATACCCCCTCATGGTAAAAC	0.343000													12	48					0	0	0.013537	0	0
CNST	163882	broad.mit.edu	37	1	246797846	246797846	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:246797846G>A	ENST00000366513.4	+	6	1044	c.775G>A	c.(775-777)Gaa>Aaa	p.E259K	CNST_ENST00000366512.3_Missense_Mutation_p.E259K|CNST_ENST00000483271.1_3'UTR	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	259					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						ATTTAATGGTGAAGATTTTGA	0.333000													6	52					0	0	0.001168	0	0
IBTK	25998	broad.mit.edu	37	6	82891624	82891624	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:82891624C>G	ENST00000306270.7	-	26	4246	c.3697G>C	c.(3697-3699)Gaa>Caa	p.E1233Q	IBTK_ENST00000503631.1_Missense_Mutation_p.E1032Q|IBTK_ENST00000510291.1_Missense_Mutation_p.E1218Q	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	1233					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TGAGAATTTTCAATTCCTTTA	0.308000													3	27					0	0	0.004672	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865104	140865104	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:140865104G>C	ENST00000306593.1	+	1	364	c.364G>C	c.(364-366)Gag>Cag	p.E122Q	PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGAGGTAGAGATCGTAGA	0.582000													5	83					0	0	0.003080	0	0
LINGO4	339398	broad.mit.edu	37	1	151773402	151773402	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:151773402G>C	ENST00000368820.3	-	2	2716	c.1779C>G	c.(1777-1779)ttC>ttG	p.F593L		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	593						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAAGGTCAGAAGAGCTTGG	0.547000													17	59					0	0	0.004007	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635437	122635437	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:122635437G>A	ENST00000249284.2	-	1	317	c.252C>T	c.(250-252)acC>acT	p.T84T		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	84					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AAAATTCCCAGGTGATTGTTA	0.398000													7	30					0	0	0.001984	0	0
RFPL1	5988	broad.mit.edu	37	22	29835036	29835036	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:29835036C>G	ENST00000354373.2	+	1	465	c.256C>G	c.(256-258)Cag>Gag	p.Q86E	RFPL1S_ENST00000461286.3_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	86							zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						CATGGTCTCTCAGAAGAACAA	0.522000													9	111					0	0	0.010729	0	0
TNNT1	7138	broad.mit.edu	37	19	55652318	55652318	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:55652318C>T	ENST00000588981.1	-	9	524	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	TNNT1_ENST00000585321.2_Missense_Mutation_p.R37Q|TNNT1_ENST00000536926.1_Missense_Mutation_p.R96Q|TNNT1_ENST00000587465.2_Missense_Mutation_p.R37Q|TNNT1_ENST00000356783.5_Missense_Mutation_p.R96Q|TNNT1_ENST00000588426.1_Intron|TNNT1_ENST00000587758.1_Missense_Mutation_p.R96Q|TNNT1_ENST00000592920.1_5'UTR|TNNT1_ENST00000291901.8_Missense_Mutation_p.R107Q	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	107					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		TCTCTCTGACCGGCGCCGCTC	0.602000											OREG0025677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	36					0	0	0.009096	0	0
TEX14	56155	broad.mit.edu	37	17	56690847	56690847	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:56690847C>G	ENST00000389934.3	-	9	1057	c.940G>C	c.(940-942)Gag>Cag	p.E314Q	TEX14_ENST00000349033.5_Missense_Mutation_p.E314Q|TEX14_ENST00000240361.8_Missense_Mutation_p.E320Q	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	320	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGGTTTTCTCTAGGTCCTGG	0.498000													30	57					0	0	0.012213	0	0
PCDH12	51294	broad.mit.edu	37	5	141336615	141336615	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:141336615C>T	ENST00000231484.3	-	1	2012	c.802G>A	c.(802-804)Gcc>Acc	p.A268T		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	268	Cadherin 3.				neuron recognition	integral to plasma membrane	calcium ion binding	p.A268T(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTCTGTGGCGGTCAGTTTT	0.527000													25	35					0	0	0.004656	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011463	105011463	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:105011463G>C	ENST00000372582.1	+	11	2626	c.1870G>C	c.(1870-1872)Gag>Cag	p.E624Q	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E624Q	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	624					central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTATAAACATGAGATACCAGC	0.478000													9	118					0	0	0.004482	0	0
ADCY2	108	broad.mit.edu	37	5	7743786	7743786	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:7743786C>T	ENST00000338316.4	+	15	1966	c.1877C>T	c.(1876-1878)tCc>tTc	p.S626F	ADCY2_ENST00000537121.1_Missense_Mutation_p.S446F|RP11-711G10.1_ENST00000514105.2_RNA	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	626					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGTAGAACGTCCGTCCTGGGC	0.493000													42	194					0	0	0.013114	0	0
STK16	8576	broad.mit.edu	37	2	220112206	220112206	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:220112206G>C	ENST00000409638.3	+	5	682	c.510G>C	c.(508-510)atG>atC	p.M170I	STK16_ENST00000409260.1_Missense_Mutation_p.M215I|STK16_ENST00000486813.1_3'UTR|STK16_ENST00000396738.2_Missense_Mutation_p.M170I|STK16_ENST00000409743.1_Missense_Mutation_p.M170I|STK16_ENST00000409516.3_Missense_Mutation_p.M52I	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	170	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGGTTCCATGAATCAAGCAT	0.507000													29	143					0	0	0.008361	0	0
GANC	2595	broad.mit.edu	37	15	42632035	42632035	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:42632035G>C	ENST00000318010.8	+	17	2252	c.2012G>C	c.(2011-2013)aGa>aCa	p.R671T		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	671					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GAAGCCATCAGAGAGCGCTAT	0.542000													6	41					0	0	0.001168	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38610501	38610501	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:38610501G>A	ENST00000222345.6	+	9	3356	c.2847G>A	c.(2845-2847)agG>agA	p.R949R		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	949					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGACATAAGGGAGATAGTGC	0.532000													7	115					0	0	0.003080	0	0
PHLDA3	23612	broad.mit.edu	37	1	201437671	201437671	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:201437671C>T	ENST00000367311.3	-	1	641	c.244G>A	c.(244-246)Gag>Aag	p.E82K	PHLDA3_ENST00000367309.1_Missense_Mutation_p.E82K|PHLDA3_ENST00000485436.1_5'UTR	NM_012396.3	NP_036528.1	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A, member 3	82	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding			lung(1)|prostate(1)	2						AAGTCGATCTCGCCGCCCCCT	0.652000													16	70					0	0	0.006122	0	0
GH1	2688	broad.mit.edu	37	17	61995219	61995219	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:61995219G>A	ENST00000323322.5	-	4	399	c.357C>T	c.(355-357)ctC>ctT	p.L119L	GH1_ENST00000342364.4_Intron|GH1_ENST00000351388.4_Silent_p.L79L|GH1_ENST00000458650.2_Silent_p.L104L|CSHL1_ENST00000392824.4_Intron	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	119					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						AGACACTCCTGAGGAACTGCA	0.607000													13	80					0	0	0.001855	0	0
IKBKE	9641	broad.mit.edu	37	1	206653236	206653236	+	Missense_Mutation	SNP	G	G	A	rs143491598		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:206653236G>A	ENST00000367120.3	+	11	1580	c.1207G>A	c.(1207-1209)Gtc>Atc	p.V403I	IKBKE_ENST00000537984.1_Missense_Mutation_p.V318I	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	403					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					CCCCAAGTTCGTCCCCAAAGT	0.592000											OREG0014170	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	46					0	0	0.009096	0	0
LOC344967	344967	broad.mit.edu	37	4	40045292	40045292	+	RNA	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:40045292C>G	ENST00000381811.2	-	0	857					NR_027277.1																						TCCATGCGCTCCAGCTTCTGG	0.587000													6	12					0	0	0.001984	0	0
NLRC5	84166	broad.mit.edu	37	16	57059987	57059987	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:57059987C>A	ENST00000436936.1	+	6	1357	c.1132C>A	c.(1132-1134)Cac>Aac	p.H378N	NLRC5_ENST00000308149.7_Missense_Mutation_p.H378N|NLRC5_ENST00000539144.1_Missense_Mutation_p.H378N|NLRC5_ENST00000262510.6_Missense_Mutation_p.H378N			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	378	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				ATATGTGAATCACTTCTTCAG	0.612000													19	115					1.01871e-10	1.0998e-10	0.008871	1	0
RUNX1T1	862	broad.mit.edu	37	8	92972521	92972521	+	Silent	SNP	C	C	T	rs144186445		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:92972521C>T	ENST00000523629.1	-	12	2218	c.1764G>A	c.(1762-1764)ccG>ccA	p.P588P	RUNX1T1_ENST00000396218.1_Silent_p.P561P|RUNX1T1_ENST00000360348.2_Silent_p.P551P|RUNX1T1_ENST00000422361.2_Silent_p.P551P|RUNX1T1_ENST00000518844.1_Silent_p.P561P|RUNX1T1_ENST00000520724.1_Silent_p.P551P|RUNX1T1_ENST00000265814.3_Silent_p.P588P|RUNX1T1_ENST00000436581.2_Silent_p.P599P	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	588					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGGTTGACCTCGGAGTGGCTG	0.612000													4	12					0	0	0.009096	0	0
SCAI	286205	broad.mit.edu	37	9	127734000	127734000	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:127734000C>T	ENST00000336505.6	-	16	1581	c.1523G>A	c.(1522-1524)cGa>cAa	p.R508Q	SCAI_ENST00000373549.4_Missense_Mutation_p.R531Q	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion						negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						GTTGATTTTTCGAAGATATTC	0.408000													24	96					0	0	0.003954	0	0
PUM1	9698	broad.mit.edu	37	1	31437555	31437555	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:31437555G>A	ENST00000373747.3	-	14	2391	c.2292C>T	c.(2290-2292)ctC>ctT	p.L764L	PUM1_ENST00000373741.4_Silent_p.L799L|PUM1_ENST00000257075.5_Silent_p.L763L|PUM1_ENST00000424085.2_Silent_p.L521L|PUM1_ENST00000423018.2_Silent_p.L619L|PUM1_ENST00000373742.2_Silent_p.L704L|PUM1_ENST00000440538.2_Silent_p.L737L|PUM1_ENST00000426105.2_Silent_p.L763L	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	763	Ser-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		CATGTGAAGAGAGGGAAGGAG	0.493000													29	176					0	0	0.009535	0	0
ALOX12B	242	broad.mit.edu	37	17	7983723	7983723	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:7983723G>C	ENST00000399413.3	+	2	644	c.404G>C	c.(403-405)cGg>cCg	p.R135P	ALOX12B_ENST00000319144.4_Intron																endometrium(2)	2						GGCAGGTGGCGGGGCCGCCCC	0.617000											OREG0024153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	46					0	0	0.006214	0	0
MBOAT1	154141	broad.mit.edu	37	6	20126922	20126922	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:20126922G>A	ENST00000541730.1	-	6	688	c.93C>T	c.(91-93)ccC>ccT	p.P31P	MBOAT1_ENST00000536798.1_Silent_p.P180P|MBOAT1_ENST00000324607.7_Silent_p.P180P			Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	180					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			CCAAAAAAGAGGGTTTCACTC	0.338000											OREG0017224	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	209					0	0	0.003080	0	0
CNKSR3	154043	broad.mit.edu	37	6	154754641	154754641	+	Splice_Site	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:154754641C>G	ENST00000607772.1	-	5	1052	c.508G>C	c.(508-510)Gat>Cat	p.D170H	CNKSR3_ENST00000479339.1_Splice_Site_p.D90H|CNKSR3_ENST00000433165.2_5'UTR	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	170	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		ACAAAGCAATCCTAAAGAAGG	0.368000													3	7					0	0	0.004672	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558970	113558970	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:113558970C>T	ENST00000284601.3	-	1	150	c.82G>A	c.(82-84)Gat>Aat	p.D28N		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	28					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ACTTCTTCATCTTCACAAAGA	0.398000													21	56					0	0	0.014323	0	0
EIF3A	8661	broad.mit.edu	37	10	120795652	120795652	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:120795652C>T	ENST00000369144.3	-	22	4175	c.4048G>A	c.(4048-4050)Gaa>Aaa	p.E1350K	EIF3A_ENST00000541549.1_Missense_Mutation_p.E1316K	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1350					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTCTCTTTTTCACCTTCTCTT	0.507000													17	45					0	0	0.004990	0	0
SOGA3	387104	broad.mit.edu	37	6	127836879	127836879	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:127836879G>C	ENST00000556132.1	-	2	1745	c.881C>G	c.(880-882)tCt>tGt	p.S294C	SOGA3_ENST00000368268.2_Missense_Mutation_p.S294C|SOGA3_ENST00000465909.2_Missense_Mutation_p.S294C|SOGA3_ENST00000481848.2_Missense_Mutation_p.S294C|SOGA3_ENST00000525778.1_Missense_Mutation_p.S294C	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	294						integral to membrane											AGGGGGGCCAGACACCGGGGA	0.741000													4	23					0	0	0.009096	0	0
CPD	1362	broad.mit.edu	37	17	28749923	28749923	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:28749923G>C	ENST00000225719.4	+	5	1615	c.1539G>C	c.(1537-1539)ttG>ttC	p.L513F	CPD_ENST00000543464.2_Missense_Mutation_p.L266F	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	513	Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding	p.L513F(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						AAATCTTCTTGAGAAGGTTTG	0.393000													38	76					0	0	0.008740	0	0
GPR110	266977	broad.mit.edu	37	6	46977848	46977848	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:46977848G>A	ENST00000371253.2	-	11	1538	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L	GPR110_ENST00000283297.5_Silent_p.L244L|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	441					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						AACCCCTTTTGAGTTGGCTTT	0.438000													10	70					0	0	0.008291	0	0
CD7	924	broad.mit.edu	37	17	80274695	80274695	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:80274695C>T	ENST00000584284.1	-	2	326	c.245G>A	c.(244-246)aGa>aAa	p.R82K	CD7_ENST00000312648.3_Missense_Mutation_p.R82K|CD7_ENST00000583376.1_5'UTR|CD7_ENST00000578509.1_5'UTR			P09564	CD7_HUMAN	CD7 molecule	82	Ig-like.				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity			endometrium(1)|large_intestine(1)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			CCGGAACCGTCTGTCCGTAGT	0.637000													37	84					0	0	0.003271	0	0
TTLL7	79739	broad.mit.edu	37	1	84403570	84403570	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:84403570G>C	ENST00000260505.8	-	8	1230	c.853C>G	c.(853-855)Caa>Gaa	p.Q285E	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	285	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ACATCATGTTGATTTGCTTGA	0.373000													8	100					0	0	0.003080	0	0
FANCD2OS	115795	broad.mit.edu	37	3	10146259	10146259	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:10146259C>T	ENST00000450660.2	-	2	416	c.200G>A	c.(199-201)gGa>gAa	p.G67E	FANCD2OS_ENST00000524279.1_Missense_Mutation_p.G67E	NM_001164839.1	NP_001158311.1			FANCD2 opposite strand																		GGGACTCACTCCAGATTCCAG	0.557000													14	49					0	0	0.001855	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27844717	27844717	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:27844717G>A	ENST00000318304.8	+	27	3022	c.2739G>A	c.(2737-2739)ttG>ttA	p.L913L	PPFIBP1_ENST00000542629.1_Silent_p.L882L|PPFIBP1_ENST00000537927.1_Silent_p.L760L|PPFIBP1_ENST00000228425.6_Silent_p.L907L	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	913					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					TTGGGAATTTGAGAAAGAAGA	0.353000													12	63					0	0	0.013537	0	0
GPR50	9248	broad.mit.edu	37	X	150349383	150349383	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:150349383C>G	ENST00000218316.3	+	2	1397	c.1328C>G	c.(1327-1329)tCt>tGt	p.S443C		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	443	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCCTGCCTCTGTCCATTTC	0.557000													8	371					0	0	0.003080	0	0
VMP1	81671	broad.mit.edu	37	17	57917167	57917167	+	Silent	SNP	C	C	T	rs111262775	byFrequency	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:57917167C>T	ENST00000262291.4	+	12	1426	c.1116C>T	c.(1114-1116)gtC>gtT	p.V372V	VMP1_ENST00000539763.1_Silent_p.V180V|VMP1_ENST00000536180.1_Silent_p.V275V|VMP1_ENST00000537567.1_Silent_p.V238V|VMP1_ENST00000588617.1_3'UTR|VMP1_ENST00000545362.1_Silent_p.V316V	NM_030938.3	NP_112200.2	Q96GC9	VMP1_HUMAN	vacuole membrane protein 1	372					autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|skin(2)	16						AAAAGTTGGTCGTTGTCATGG	0.388000													32	195					0	0	0.013726	0	0
ANO9	338440	broad.mit.edu	37	11	431718	431718	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:431718C>T	ENST00000332826.6	-	7	599	c.515G>A	c.(514-516)cGg>cAg	p.R172Q		NM_001012302.2	NP_001012302	A1A5B4	ANO9_HUMAN	anoctamin 9	172						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						TGGCTGCTCCCGGAACATGTG	0.667000													5	17					0	0	0.000602	0	0
MAN1C1	57134	broad.mit.edu	37	1	26104650	26104650	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:26104650G>A	ENST00000374332.4	+	9	1642	c.1312G>A	c.(1312-1314)Gag>Aag	p.E438K	MAN1C1_ENST00000263979.3_Missense_Mutation_p.E258K|MAN1C1_ENST00000374329.1_Missense_Mutation_p.E209K	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	438					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		CTACATTGCCGAGTGGCGAGG	0.627000													4	62					0	0	0.001168	0	0
ARID1A	8289	broad.mit.edu	37	1	27056160	27056160	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:27056160C>T	ENST00000324856.7	+	2	1527	c.1156C>T	c.(1156-1158)Cag>Tag	p.Q386*	ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q3*|ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q386*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	386					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCCAATGGATCAGATGGGCAA	0.498000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								27	91					0	0	0.008361	0	0
KIF1A	547	broad.mit.edu	37	2	241706751	241706751	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:241706751G>C	ENST00000498729.2	-	18	1755	c.1509C>G	c.(1507-1509)ctC>ctG	p.L503L	KIF1A_ENST00000320389.7_Silent_p.L494L	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	494					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TCAGGTTGACGAGGTGTGGTG	0.607000													3	19					0	0	0.009096	0	0
CCDC53	51019	broad.mit.edu	37	12	102455053	102455053	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:102455053G>A	ENST00000240079.6	-	2	284	c.123C>T	c.(121-123)ctC>ctT	p.L41L	CCDC53_ENST00000539515.1_5'UTR|CCDC53_ENST00000545679.1_Silent_p.L41L	NM_016053.2	NP_057137.1	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	41						WASH complex	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						AAAAGCGGTTGAGGAACTGTA	0.438000													11	34					0	0	0.002450	0	0
TRIM63	84676	broad.mit.edu	37	1	26387813	26387813	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:26387813C>T	ENST00000374272.3	-	3	483	c.345G>A	c.(343-345)caG>caA	p.Q115Q	TRIM63_ENST00000483052.1_5'UTR	NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	115	Interaction with TTN.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GACTGCCCTTCTGCAGCGGCC	0.577000													3	66					0	0	0.009096	0	0
LAT	27040	broad.mit.edu	37	16	28997739	28997739	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:28997739G>A	ENST00000395456.2	+	5	604	c.282G>A	c.(280-282)acG>acA	p.T94T	RP11-264B17.3_ENST00000569969.1_RNA|LAT_ENST00000454369.2_Silent_p.T93T|LAT_ENST00000563964.1_3'UTR|LAT_ENST00000360872.5_Silent_p.T94T|LAT_ENST00000395461.3_Silent_p.T130T|LAT_ENST00000564277.1_Silent_p.T93T|LAT_ENST00000566177.1_Silent_p.T93T|LAT_ENST00000354453.4_Intron	NM_001014987.1|NM_001014988.1|NM_014387.3	NP_001014987.1|NP_001014988.1|NP_055202.1	O43561	LAT_HUMAN	linker for activation of T cells	94					calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity			large_intestine(2)|lung(3)|urinary_tract(1)	6		Hepatocellular(780;0.244)				CCCACCGGACGCCATCTTCCC	0.627000													29	67					0	0	0.009535	0	0
ZNF681	148213	broad.mit.edu	37	19	23938261	23938261	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:23938261C>G	ENST00000402377.3	-	2	237	c.96G>C	c.(94-96)gtG>gtC	p.V32V	ZNF681_ENST00000395385.3_Intron	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TCTCTAACATCACATTCCTAT	0.358000													17	95					0	0	0.007413	0	0
MTOR	2475	broad.mit.edu	37	1	11297958	11297958	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:11297958C>T	ENST00000361445.4	-	13	2226	c.2150G>A	c.(2149-2151)cGa>cAa	p.R717Q		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	717					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity	p.R717L(1)		breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GCTACTGAGTCGGCCCACAGT	0.582000													25	57					0	0	0.005443	0	0
SP100	6672	broad.mit.edu	37	2	231406036	231406036	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:231406036G>C	ENST00000340126.4	+	27	2383	c.2352G>C	c.(2350-2352)ttG>ttC	p.L784F	AC010149.4_ENST00000414539.1_RNA|AC010149.4_ENST00000455357.1_RNA	NM_001080391.1	NP_001073860.1	P23497	SP100_HUMAN	SP100 nuclear antigen	0					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCCTCCTCTTGAAGGTCTACT	0.388000													8	45					0	0	0.008291	0	0
ZNF329	79673	broad.mit.edu	37	19	58640693	58640693	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:58640693G>C	ENST00000598312.1	-	4	411	c.178C>G	c.(178-180)Cag>Gag	p.Q60E	ZNF329_ENST00000358067.4_Missense_Mutation_p.Q60E	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	60					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		ATTGCTTCCTGAGTCCCTGGT	0.488000													3	120					0	0	0.004672	0	0
MURC	347273	broad.mit.edu	37	9	103348453	103348453	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:103348453G>A	ENST00000307584.5	+	2	880	c.815G>A	c.(814-816)cGc>cAc	p.R272H		NM_001018116.1	NP_001018126.1	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	272					cell differentiation|muscle organ development|transcription, DNA-dependent					endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)	16		Acute lymphoblastic leukemia(62;0.0461)				TTTAAGATGCGCAGCCTCAGG	0.537000													25	104					0	0	0.006320	0	0
SCFD2	152579	broad.mit.edu	37	4	53751964	53751964	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:53751964C>T	ENST00000401642.3	-	8	2045	c.1912G>A	c.(1912-1914)Gaa>Aaa	p.E638K	SCFD2_ENST00000388940.4_Missense_Mutation_p.E593K	NM_152540.3	NP_689753.2	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	638					protein transport|vesicle docking involved in exocytosis					breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	30			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ATTTTCACTTCAGAGACTGTG	0.498000													15	42					0	0	0.003163	0	0
PDZRN4	29951	broad.mit.edu	37	12	41587902	41587902	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:41587902C>T	ENST00000402685.2	+	3	763	c.755C>T	c.(754-756)tCg>tTg	p.S252L		NM_001164595.1	NP_001158067.1	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	252	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGGAACATCGACTGAAGGA	0.318000													4	29					0	0	0.009096	0	0
HSH2D	84941	broad.mit.edu	37	19	16268238	16268238	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:16268238C>T	ENST00000253680.6	+	9	1223	c.692C>T	c.(691-693)tCg>tTg	p.S231L	HSH2D_ENST00000588246.1_Silent_p.V231V|HSH2D_ENST00000593154.2_Silent_p.V231V|HSH2D_ENST00000397372.4_Missense_Mutation_p.S141L			Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	231						cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|large_intestine(2)	4						GTGAACTTGTCGTCACTCTTG	0.602000													8	74					0	0	0.003080	0	0
ABCA8	10351	broad.mit.edu	37	17	66872823	66872823	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:66872823C>T	ENST00000269080.2	-	32	4238	c.4101G>A	c.(4099-4101)ctG>ctA	p.L1367L	ABCA8_ENST00000430352.2_Silent_p.L1407L|ABCA8_ENST00000586539.1_Silent_p.L1407L	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1367	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GCTGGTCCTGCAGCTTGAGCG	0.498000													22	75					0	0	0.003330	0	0
KLB	152831	broad.mit.edu	37	4	39448977	39448977	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:39448977G>C	ENST00000257408.4	+	4	2728	c.2631G>C	c.(2629-2631)cgG>cgC	p.R877R		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	877	Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						GGTGGGTCCGGAGGAACTACG	0.622000													20	73					0	0	0.008871	0	0
APBB1	322	broad.mit.edu	37	11	6432324	6432324	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:6432324C>T	ENST00000389906.2	-	2	353	c.254G>A	c.(253-255)cGt>cAt	p.R85H	APBB1_ENST00000299402.6_Missense_Mutation_p.R85H|APBB1_ENST00000609360.1_Missense_Mutation_p.R85H|APBB1_ENST00000311051.3_Missense_Mutation_p.R85H			O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	85					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		ATTCTGGTCACGGTGGGCCGT	0.652000													29	135					0	0	0.008361	0	0
TP53	7157	broad.mit.edu	37	17	7578513	7578513	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:7578513C>G	ENST00000420246.2	-	5	549	c.417G>C	c.(415-417)aaG>aaC	p.K139N	TP53_ENST00000413465.2_Missense_Mutation_p.K139N|TP53_ENST00000359597.4_Missense_Mutation_p.K139N|TP53_ENST00000445888.2_Missense_Mutation_p.K139N|TP53_ENST00000269305.4_Missense_Mutation_p.K139N|TP53_ENST00000455263.2_Missense_Mutation_p.K139N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	139	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		K -> E (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K139N(9)|p.0?(8)|p.K139K(7)|p.A138_P142delAKTCP(4)|p.C135fs*9(3)|p.K139_T140delKT(3)|p.N131fs*27(2)|p.L137_W146del10(1)|p.K139fs*9(1)|p.K46_T47delKT(1)|p.F134_T140>S(1)|p.A45_P49delAKTCP(1)|p.K7_T8delKT(1)|p.C3fs*9(1)|p.A6_P10delAKTCP(1)|p.A138_V143delAKTCPV(1)|p.K139fs*10(1)|p.K139fs*4(1)|p.C42fs*9(1)|p.Q136_K139delQLAK(1)|p.K139_C141>N(1)|p.C135_T140delCQLAKT(1)|p.K139fs*29(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGCAGGTCTTGGCCAGTT	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	12					0	0	0.013114	0	0
GANC	2595	broad.mit.edu	37	15	42632010	42632010	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:42632010A>C	ENST00000318010.8	+	17	2227	c.1987A>C	c.(1987-1989)Acc>Ccc	p.T663P		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	663					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GGAGGAACACACCCGACTCAT	0.572000													5	41					0	0	0.001168	0	0
TTC9	23508	broad.mit.edu	37	14	71137855	71137855	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:71137855G>C	ENST00000256367.2	+	3	995	c.652G>C	c.(652-654)Gaa>Caa	p.E218Q		NM_015351.1	NP_056166.1	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	218							binding			skin(1)	1				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		CTCCCAGAGAGAAAAAGAAGC	0.557000													7	28					0	0	0.001984	0	0
LRP1	4035	broad.mit.edu	37	12	57556275	57556275	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:57556275G>A	ENST00000243077.3	+	14	2844	c.2378G>A	c.(2377-2379)cGa>cAa	p.R793Q		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	793					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTTGAGATCCGAATGTATGAT	0.607000													7	77					0	0	0.001984	0	0
ADAM2	2515	broad.mit.edu	37	8	39613416	39613416	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:39613416C>G	ENST00000265708.4	-	16	1731	c.1628G>C	c.(1627-1629)gGa>gCa	p.G543A	ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000521880.1_Intron|ADAM2_ENST00000347580.4_Missense_Mutation_p.G524A	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	543	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	p.G543E(1)		haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TATTAATTTTCCGCACTGCAG	0.244000													8	54					0	0	0.003080	0	0
RB1	5925	broad.mit.edu	37	13	48881462	48881462	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:48881462C>T	ENST00000267163.4	+	2	322	c.184C>T	c.(184-186)Cag>Tag	p.Q62*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	62					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(3)|p.Q62*(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGCATTATGTCAGAAATTAAA	0.323000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			6	26					0	0	0.001168	0	0
DNAJC30	84277	broad.mit.edu	37	7	73097498	73097498	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:73097498C>T	ENST00000395176.2	-	1	285	c.256G>A	c.(256-258)Gag>Aag	p.E86K	WBSCR22_ENST00000464615.1_3'UTR	NM_032317.2	NP_115693.2	Q96LL9	DJC30_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 30	86	J.				protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)	4						TCGGCGGCCTCCGCGCTCCCG	0.662000													20	70					0	0	0.008871	0	0
PHLPP2	23035	broad.mit.edu	37	16	71701149	71701149	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:71701149G>C	ENST00000393524.2	-	11	2449	c.1716C>G	c.(1714-1716)ctC>ctG	p.L572L	PHLPP2_ENST00000567016.1_Silent_p.L607L|PHLPP2_ENST00000568954.1_Silent_p.L572L|PHLPP2_ENST00000360429.3_Silent_p.L572L|PHLPP2_ENST00000356272.3_Silent_p.L572L			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	646						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CCAGCACCTCGAGGGGGATGT	0.478000													6	71					0	0	0.001168	0	0
ESYT1	23344	broad.mit.edu	37	12	56531825	56531825	+	Silent	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:56531825C>A	ENST00000394048.5	+	20	2478	c.2214C>A	c.(2212-2214)ctC>ctA	p.L738L	ESYT1_ENST00000550878.1_3'UTR|ESYT1_ENST00000541590.1_Silent_p.L748L|ESYT1_ENST00000267113.4_Silent_p.L748L	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	738				L -> F (in Ref. 2; BAB15139).		integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						AAGTGCGTCTCACCACAGTCT	0.473000													36	93					2.51541e-25	2.75679e-25	0.004878	1	0
GRIN2C	2905	broad.mit.edu	37	17	72845996	72845996	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:72845996G>T	ENST00000293190.5	-	7	1714	c.1568C>A	c.(1567-1569)tCt>tAt	p.S523Y	GRIN2C_ENST00000347612.4_Missense_Mutation_p.S523Y	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	523					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	AAAGGGTACAGAGAAGTCTAC	0.622000													25	76					1.85244e-09	1.99e-09	0.003330	1	0
RBMX2	51634	broad.mit.edu	37	X	129545341	129545341	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:129545341G>A	ENST00000305536.6	+	5	387	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	RBMX2_ENST00000469953.1_3'UTR	NM_016024.2	NP_057108.2	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	108	RRM.						nucleotide binding|RNA binding			breast(4)|endometrium(2)|large_intestine(1)|liver(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	19						AGAACTATCCGAGTGGATCAT	0.478000													8	89					0	0	0.003080	0	0
TCOF1	6949	broad.mit.edu	37	5	149758896	149758896	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:149758896G>A	ENST00000451292.1	+	16	2691	c.2583G>A	c.(2581-2583)caG>caA	p.Q861Q	TCOF1_ENST00000513346.1_Silent_p.Q861Q|TCOF1_ENST00000445265.2_Silent_p.Q784Q|TCOF1_ENST00000394269.3_Silent_p.Q861Q|TCOF1_ENST00000377797.3_Silent_p.Q861Q|TCOF1_ENST00000504761.2_Silent_p.Q861Q|TCOF1_ENST00000439160.2_Silent_p.Q861Q|TCOF1_ENST00000506063.1_3'UTR|TCOF1_ENST00000323668.7_Silent_p.Q784Q			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	861					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCAGGCCCAGACAGGGCCAG	0.627000													25	37					0	0	0.002780	0	0
CLK3	1198	broad.mit.edu	37	15	74912356	74912356	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:74912356C>T	ENST00000395066.3	+	3	1064	c.603C>T	c.(601-603)gaC>gaT	p.D201D	CLK3_ENST00000352989.5_Silent_p.D53D|CLK3_ENST00000348245.3_Silent_p.D53D|CLK3_ENST00000345005.4_Silent_p.D53D	NM_001130028.1	NP_001123500.1	P49761	CLK3_HUMAN	CDC-like kinase 3	201	Arg-rich.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)|stomach(2)|urinary_tract(1)	15						GCAGCCATGACCGCCTGCCCT	0.587000													13	51					0	0	0.002450	0	0
DNAH11	8701	broad.mit.edu	37	7	21603941	21603941	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:21603941C>G	ENST00000328843.6	+	6	1151	c.1120C>G	c.(1120-1122)Cat>Gat	p.H374D	DNAH11_ENST00000409508.3_Missense_Mutation_p.H374D			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	374	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GATCTGGAGTCATTCCAAGTT	0.413000									Kartagener syndrome				7	41					0	0	0.001984	0	0
KCNU1	157855	broad.mit.edu	37	8	36642013	36642013	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:36642013C>T	ENST00000399881.3	+	1	122	c.85C>T	c.(85-87)Ctc>Ttc	p.L29F		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	29						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.L29I(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AGCATTCATTCTCTCTTCCTT	0.423000													5	37					0	0	0.000602	0	0
PHACTR1	221692	broad.mit.edu	37	6	13182823	13182823	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:13182823C>T	ENST00000379350.1	+	6	698	c.569C>T	c.(568-570)tCt>tTt	p.S190F	PHACTR1_ENST00000457702.2_Missense_Mutation_p.S45F|PHACTR1_ENST00000379345.2_Missense_Mutation_p.S45F|PHACTR1_ENST00000332995.7_Missense_Mutation_p.S190F			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	190						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			AGCCAGCTGTCTCTGCCTGCC	0.537000													4	234					0	0	0.009096	0	0
POLQ	10721	broad.mit.edu	37	3	121208086	121208086	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:121208086G>C	ENST00000264233.5	-	16	3820	c.3692C>G	c.(3691-3693)tCa>tGa	p.S1231*		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1231					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		AGTAACATTTGAGTCTCTATT	0.333000								DNA polymerases (catalytic subunits)					33	134					0	0	0.012213	0	0
NEB	4703	broad.mit.edu	37	2	152470790	152470790	+	Splice_Site	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:152470790A>G	ENST00000427231.2	-	77	11803	c.11601T>C	c.(11599-11601)gaT>gaC	p.D3867D	NEB_ENST00000409198.1_Splice_Site_p.D3624D|NEB_ENST00000172853.10_Splice_Site_p.D3624D|NEB_ENST00000603639.1_Splice_Site_p.D3867D|NEB_ENST00000397345.3_Splice_Site_p.D3867D|NEB_ENST00000604864.1_Splice_Site_p.D3867D	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	3867					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGCCACTCACATCACTCTGCA	0.458000													19	32					0	0	0.012319	0	0
RBM11	54033	broad.mit.edu	37	21	15588577	15588577	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr21:15588577G>A	ENST00000400577.3	+	1	79	c.70G>A	c.(70-72)Gag>Aag	p.E24K	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	24	RRM.						nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		AGTTCGGGAAGAGATTCTGTA	0.612000													3	24					0	0	0.004672	0	0
POLA2	23649	broad.mit.edu	37	11	65055264	65055264	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:65055264G>A	ENST00000265465.3	+	11	1615	c.1084G>A	c.(1084-1086)Gac>Aac	p.D362N	POLA2_ENST00000541089.1_Missense_Mutation_p.D154N	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	362					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	CCCCCTGCTTGACCTGATTGC	0.502000													5	74					0	0	0.000602	0	0
DMXL2	23312	broad.mit.edu	37	15	51758502	51758502	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:51758502G>C	ENST00000251076.5	-	30	7683	c.7396C>G	c.(7396-7398)Ctt>Gtt	p.L2466V	DMXL2_ENST00000449909.3_Missense_Mutation_p.L1830V|DMXL2_ENST00000543779.2_Missense_Mutation_p.L2467V|RP11-707P17.1_ENST00000561007.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2466						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GACAAAGGAAGAAATGGCTGC	0.239000													13	51					0	0	0.001855	0	0
KIAA1377	57562	broad.mit.edu	37	11	101849120	101849120	+	Missense_Mutation	SNP	G	G	A	rs150274963	byFrequency	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:101849120G>A	ENST00000263468.8	+	7	3158	c.2888G>A	c.(2887-2889)cGg>cAg	p.R963Q	KIAA1377_ENST00000537689.1_Missense_Mutation_p.R764Q	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	963							protein binding	p.R963Q(1)		breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAAACTAAGCGGAGAAATATT	0.333000													5	180					0	0	0.000602	0	0
SGK223	157285	broad.mit.edu	37	8	8175697	8175697	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:8175697C>T	ENST00000520004.1	-	6	4452	c.4188G>A	c.(4186-4188)ctG>ctA	p.L1396L	SGK223_ENST00000330777.4_Silent_p.L1396L			Q86YV5	SG223_HUMAN		1396							ATP binding|non-membrane spanning protein tyrosine kinase activity										GCAGGAGCTTCAGCGACTGTA	0.657000													8	29					0	0	0.003080	0	0
SLC30A6	55676	broad.mit.edu	37	2	32396442	32396442	+	Splice_Site	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:32396442G>C	ENST00000282587.5	+	2	127	c.90G>C	c.(88-90)agG>agC	p.R30S	SLC30A6_ENST00000406369.1_Intron|SLC30A6_ENST00000538303.1_Intron|SLC30A6_ENST00000357055.3_5'UTR|SLC30A6_ENST00000379343.2_Splice_Site_p.R30S|SLC30A6_ENST00000435660.1_Splice_Site_p.R30S	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	30						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTGACCGAAGGGTAAGTTATT	0.348000													7	36					0	0	0.003080	0	0
CDIP1	29965	broad.mit.edu	37	16	4563773	4563773	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:4563773C>G	ENST00000399599.3	-	3	713	c.165G>C	c.(163-165)gaG>gaC	p.E55D	CDIP1_ENST00000562334.1_Intron|CDIP1_ENST00000567695.1_Missense_Mutation_p.E55D|CDIP1_ENST00000563332.2_Missense_Mutation_p.E55D|CDIP1_ENST00000563507.1_Missense_Mutation_p.E55D|CDIP1_ENST00000564828.1_Missense_Mutation_p.E20D					cell death-inducing p53 target 1																		GACCCGGCGGCTCATAGGGTG	0.647000													15	53					0	0	0.003163	0	0
DNAH8	1769	broad.mit.edu	37	6	38783350	38783350	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:38783350G>A	ENST00000359357.3	+	24	3043	c.2789G>A	c.(2788-2790)cGt>cAt	p.R930H	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1147H|DNAH8_ENST00000441566.1_Missense_Mutation_p.R930H					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CAGCAAATCCGTCCCATCAAG	0.463000													5	32					0	0	0.000602	0	0
C4orf22	255119	broad.mit.edu	37	4	81283911	81283911	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:81283911G>A	ENST00000358105.3	+	2	164	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	C4orf22_ENST00000512931.1_3'UTR|C4orf22_ENST00000508675.1_Missense_Mutation_p.E39K	NM_152770.2	NP_689983.2	Q6V702	CD022_HUMAN	chromosome 4 open reading frame 22	39										NS(1)|large_intestine(3)|lung(5)|prostate(1)|skin(5)	15						TCTCTAGGATGAAACCCTGGC	0.433000													24	110					0	0	0.004656	0	0
OR2L8	391190	broad.mit.edu	37	1	248112934	248112934	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:248112934C>G	ENST00000357191.3	+	1	775	c.775C>G	c.(775-777)Cta>Gta	p.L259V	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CTACACTTATCTACGTCCAAG	0.483000													25	73					0	0	0.010818	0	0
MYH10	4628	broad.mit.edu	37	17	8395764	8395764	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:8395764C>T	ENST00000360416.3	-	34	4660	c.4522G>A	c.(4522-4524)Gag>Aag	p.E1508K	MYH10_ENST00000396239.1_Missense_Mutation_p.E1498K|MYH10_ENST00000269243.4_Missense_Mutation_p.E1477K|MYH10_ENST00000379980.4_Missense_Mutation_p.E1493K	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1477					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TCTCTGGCCTCGGCTTCGGCC	0.592000													4	72					0	0	0.009096	0	0
ZNF587	84914	broad.mit.edu	37	19	58371385	58371385	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:58371385C>T	ENST00000339656.5	+	3	1787	c.1605C>T	c.(1603-1605)ctC>ctT	p.L535L	ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF587_ENST00000423137.1_Silent_p.L534L|ZNF814_ENST00000597342.1_Intron|ZNF587_ENST00000419854.1_Silent_p.L492L	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		GTTCCAGTCTCATTAAACACA	0.403000													16	89					0	0	0.004990	0	0
MED23	9439	broad.mit.edu	37	6	131927625	131927625	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:131927625T>C	ENST00000403834.3	-	13	1552	c.1379A>G	c.(1378-1380)cAc>cGc	p.H460R	MED23_ENST00000354577.4_Missense_Mutation_p.H460R|MED23_ENST00000368058.1_Missense_Mutation_p.H460R|MED23_ENST00000545957.1_Missense_Mutation_p.H95R|MED23_ENST00000368068.3_Missense_Mutation_p.H454R|MED23_ENST00000368053.4_Missense_Mutation_p.H460R|MED23_ENST00000540546.1_Missense_Mutation_p.H460R|MED23_ENST00000368060.3_Missense_Mutation_p.H454R|MED23_ENST00000539158.1_Missense_Mutation_p.H454R			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	454					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TTACTCATGGTGAAGTCTTAG	0.348000													8	36					0	0	0.008291	0	0
CAB39	51719	broad.mit.edu	37	2	231683405	231683405	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:231683405C>T	ENST00000258418.5	+	9	1441	c.1012C>T	c.(1012-1014)Cag>Tag	p.Q338*	CAB39_ENST00000409788.3_Nonsense_Mutation_p.Q338*|CAB39_ENST00000410084.3_Nonsense_Mutation_p.Q338*	NM_016289.3	NP_057373.1	Q9Y376	CAB39_HUMAN	calcium binding protein 39	338					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)|large_intestine(1)|skin(1)	3		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		GAGACCAGCTCAGCAAGAAGC	0.403000													8	12					0	0	0.004482	0	0
NRF1	4899	broad.mit.edu	37	7	129394931	129394931	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:129394931G>A	ENST00000393232.1	+	11	1539	c.1422G>A	c.(1420-1422)caG>caA	p.Q474Q	NRF1_ENST00000539636.1_Silent_p.Q313Q|NRF1_ENST00000393230.2_Silent_p.Q474Q|NRF1_ENST00000223190.4_Silent_p.Q474Q|NRF1_ENST00000353868.4_Silent_p.Q408Q|NRF1_ENST00000311967.2_Silent_p.Q493Q|NRF1_ENST00000393231.3_Silent_p.Q493Q	NM_005011.3	NP_005002.3	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	474	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	24						GACCAGTGCAGGTGGCCATGG	0.592000													10	42					0	0	0.006214	0	0
ZNF420	147923	broad.mit.edu	37	19	37619283	37619283	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:37619283C>T	ENST00000337995.3	+	5	1605	c.1390C>T	c.(1390-1392)Caa>Taa	p.Q464*	ZNF585A_ENST00000588723.1_Intron|ZNF420_ENST00000304239.7_Nonsense_Mutation_p.Q464*	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGAACTTACTCAACATGAGCG	0.423000													4	80					0	0	0.009096	0	0
MIR7-2	407044	broad.mit.edu	37	15	89155074	89155074	+	RNA	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:89155074G>A	ENST00000384970.1	+	0	19					NR_029606.1|NR_039867.1																						AGAGTGGACCGGCTGGCCCCA	0.597000													3	7					0	0	0.004672	0	0
GPR110	266977	broad.mit.edu	37	6	46977428	46977428	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:46977428G>C	ENST00000371253.2	-	11	1958	c.1743C>G	c.(1741-1743)atC>atG	p.I581M	GPR110_ENST00000283297.5_Missense_Mutation_p.I384M|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	581					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CAACGGGGAAGATTGTAGAGG	0.448000													13	54					0	0	0.013537	0	0
DNAH7	56171	broad.mit.edu	37	2	196671502	196671502	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:196671502G>C	ENST00000312428.6	-	54	10238	c.10138C>G	c.(10138-10140)Caa>Gaa	p.Q3380E		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3380					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGCATCCTTTGAAACTCATTT	0.383000													17	36					0	0	0.004007	0	0
GGA1	26088	broad.mit.edu	37	22	38021890	38021890	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:38021890G>A	ENST00000406772.1	+	12	1460	c.808G>A	c.(808-810)Gag>Aag	p.E270K	GGA1_ENST00000343632.4_Missense_Mutation_p.E343K|GGA1_ENST00000381756.5_Missense_Mutation_p.E360K|GGA1_ENST00000325180.8_Intron|GGA1_ENST00000337437.4_Missense_Mutation_p.E310K	NM_001172688.1	NP_001166159.1	Q9UJY5	GGA1_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	343	GAT.|Interaction with ARF3.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	10	Melanoma(58;0.0574)					CCGCCCTGGCGAGCAGGCCAG	0.687000													12	43					0	0	0.013537	0	0
SPTAN1	6709	broad.mit.edu	37	9	131388736	131388736	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:131388736G>A	ENST00000372739.3	+	49	6456	c.6346G>A	c.(6346-6348)Gag>Aag	p.E2116K	SPTAN1_ENST00000372731.4_Missense_Mutation_p.E2111K|SPTAN1_ENST00000358161.5_Missense_Mutation_p.E2116K	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2111					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						TGAAAATGCAGAGGAGGACTT	0.567000													18	137					0	0	0.004990	0	0
TRAV18	28665	broad.mit.edu	37	14	22471622	22471622	+	RNA	SNP	A	A	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:22471622A>T	ENST00000390446.3	+	0	151																											TCCCTTTTTTAGGAAGGACCA	0.458000													20	59					0	0	0.008871	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634390	156634390	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:156634390G>A	ENST00000296518.7	+	7	1436	c.1227G>A	c.(1225-1227)ctG>ctA	p.L409L	GUCY1A3_ENST00000511108.1_Silent_p.L409L|GUCY1A3_ENST00000506455.1_Silent_p.L409L|GUCY1A3_ENST00000513574.1_Silent_p.L409L|GUCY1A3_ENST00000511507.1_Silent_p.L409L|GUCY1A3_ENST00000455639.2_Silent_p.L409L|GUCY1A3_ENST00000393832.3_Silent_p.L151L			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	409					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ACAATGCACTGAGGGATGTGG	0.522000													12	29					0	0	0.010729	0	0
KALRN	8997	broad.mit.edu	37	3	124174160	124174160	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:124174160G>C	ENST00000360013.3	+	22	3810	c.3683G>C	c.(3682-3684)gGa>gCa	p.G1228A	KALRN_ENST00000240874.3_Missense_Mutation_p.G1228A|KALRN_ENST00000460856.1_Missense_Mutation_p.G1219A	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1228					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTGAGGATGGGAAAGTACCGA	0.522000													12	79					0	0	0.013537	0	0
NARS	4677	broad.mit.edu	37	18	55270142	55270142	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:55270142C>T	ENST00000256854.5	-	12	1740	c.1285G>A	c.(1285-1287)Gac>Aac	p.D429N	NARS_ENST00000423481.2_Missense_Mutation_p.D180N	NM_004539.3	NP_004530.1	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	429					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			breast(1)|endometrium(5)|large_intestine(5)|lung(8)|skin(1)	20		Colorectal(73;0.227)			L-Asparagine(DB00174)	TTAATGGTGTCTGTCATCAGT	0.448000													6	53					0	0	0.001984	0	0
FAM183B	340286	broad.mit.edu	37	7	38725645	38725645	+	Translation_Start_Site	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:38725645G>A	ENST00000409072.3	-	0	895									family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						CTCTCTCGGCGTCCTCTTACC	0.622000													4	31					0	0	0.000602	0	0
MRPL34	64981	broad.mit.edu	37	19	17417150	17417150	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:17417150C>T	ENST00000252602.1	+	2	466	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	MRPL34_ENST00000595444.1_Missense_Mutation_p.R173C|MRPL34_ENST00000594999.1_Missense_Mutation_p.R81C|MRPL34_ENST00000602206.1_3'UTR|MRPL34_ENST00000600434.1_Missense_Mutation_p.R81C	NM_023937.3	NP_076426.1	Q9BQ48	RM34_HUMAN	mitochondrial ribosomal protein L34	81					translation		structural constituent of ribosome			endometrium(1)|lung(1)	2						GGTCATCCTTCGCCGAATGCT	0.652000													3	14					0	0	0.004672	0	0
FANCF	2188	broad.mit.edu	37	11	22647304	22647304	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:22647304G>C	ENST00000327470.3	-	1	83	c.53C>G	c.(52-54)tCa>tGa	p.S18*	AC103801.2_ENST00000428556.2_3'UTR	NM_022725.3	NP_073562.1	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	18					DNA repair	nucleoplasm	protein binding			kidney(3)|large_intestine(3)|lung(6)|skin(1)	13						GGTAGTGCTTGAGACCGCCAG	0.637000			"""N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	31					0	0	0.001984	0	0
AIMP2	7965	broad.mit.edu	37	7	6054965	6054965	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:6054965G>C	ENST00000223029.3	+	2	443	c.324G>C	c.(322-324)ttG>ttC	p.L108F	AIMP2_ENST00000395236.2_Intron|AIMP2_ENST00000400479.2_Missense_Mutation_p.L30F	NM_006303.3	NP_006294.2	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	108	Interaction with PARK2.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CGCTGGACTTGAATTCAGTGC	0.458000													11	48					0	0	0.008291	0	0
KDELC1	79070	broad.mit.edu	37	13	103450976	103450976	+	Silent	SNP	A	A	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:103450976A>C	ENST00000376004.4	-	1	381	c.45T>G	c.(43-45)gtT>gtG	p.V15V	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	15						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CGAGTGCTGGAACTGTCGCCA	0.532000													12	43					0	0	0.013537	0	0
PHLDA3	23612	broad.mit.edu	37	1	201437831	201437831	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:201437831C>T	ENST00000367311.3	-	1	481	c.84G>A	c.(82-84)cgG>cgA	p.R28R	PHLDA3_ENST00000367309.1_Silent_p.R28R	NM_012396.3	NP_036528.1	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A, member 3	28	PH.		R -> Q (in dbSNP:rs35383942).		anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding			lung(1)|prostate(1)	2						CGCAGCGCTTCCGCTTCCACA	0.721000													6	21					0	0	0.001168	0	0
ASB16	92591	broad.mit.edu	37	17	42255693	42255693	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:42255693C>G	ENST00000293414.1	+	5	1381	c.1297C>G	c.(1297-1299)Cgg>Ggg	p.R433G	ASB16-AS1_ENST00000585457.1_RNA|ASB16-AS1_ENST00000588785.1_RNA|ASB16-AS1_ENST00000591166.1_RNA|ASB16-AS1_ENST00000592897.1_RNA	NM_080863.4	NP_543139.4	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box containing 16	433	SOCS box.				intracellular signal transduction		protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|liver(2)|lung(2)|prostate(1)	14		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGGTGCCACCCGGCTGCCACT	0.677000													6	13					0	0	0.001984	0	0
LAMA4	3910	broad.mit.edu	37	6	112476811	112476811	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:112476811C>T	ENST00000230538.7	-	15	2312	c.1915G>A	c.(1915-1917)Gaa>Aaa	p.E639K	LAMA4_ENST00000389463.4_Missense_Mutation_p.E632K|LAMA4_ENST00000522006.1_Missense_Mutation_p.E632K|RP1-142L7.5_ENST00000585373.1_RNA|RP1-142L7.5_ENST00000588689.1_RNA|RP1-142L7.5_ENST00000425503.1_RNA|LAMA4_ENST00000424408.2_Missense_Mutation_p.E632K	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	639	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TCTGCTGTTTCATTGGCTTCA	0.388000													10	61					0	0	0.010729	0	0
HERC1	8925	broad.mit.edu	37	15	63930948	63930948	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:63930948C>G	ENST00000443617.2	-	62	12016	c.11929G>C	c.(11929-11931)Gat>Cat	p.D3977H		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3977					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ATTTGTTCATCCATGCCGTTA	0.393000													12	236					0	0	0.013537	0	0
NRP1	8829	broad.mit.edu	37	10	33619671	33619671	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:33619671G>C	ENST00000265371.4	-	3	738	c.213C>G	c.(211-213)ttC>ttG	p.F71L	NRP1_ENST00000374875.1_5'UTR|NRP1_ENST00000374867.2_Missense_Mutation_p.F71L|NRP1_ENST00000374816.3_Missense_Mutation_p.F71L|NRP1_ENST00000374822.4_Missense_Mutation_p.F71L|NRP1_ENST00000374821.5_Missense_Mutation_p.F71L|NRP1_ENST00000374823.5_Missense_Mutation_p.F71L|NRP1_ENST00000432372.2_Missense_Mutation_p.F71L|NRP1_ENST00000395995.1_Missense_Mutation_p.F71L			O14786	NRP1_HUMAN	neuropilin 1	71	CUB 1.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	AGTGAGGGTTGAAGTTGATCA	0.478000													10	44					0	0	0.006214	0	0
TRANK1	9881	broad.mit.edu	37	3	36874249	36874249	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:36874249C>G	ENST00000429976.2	-	21	6940	c.6693G>C	c.(6691-6693)aaG>aaC	p.K2231N	TRANK1_ENST00000301807.6_Missense_Mutation_p.K1681N|TRANK1_ENST00000428977.2_Missense_Mutation_p.K1681N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2231					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GATGGAAATGCTTAGGGAAAA	0.378000													32	57					0	0	0.012213	0	0
MPP3	4356	broad.mit.edu	37	17	41907106	41907106	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:41907106G>A	ENST00000398393.1	-	5	692	c.432C>T	c.(430-432)ctC>ctT	p.L144L	MPP3_ENST00000398389.4_Silent_p.L119L			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	119	PDZ.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GCAGAGGCGGGAGAACGGGGT	0.557000													23	91					0	0	0.003330	0	0
RAD51	5888	broad.mit.edu	37	15	40993283	40993283	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:40993283G>A	ENST00000267868.3	+	3	377	c.109G>A	c.(109-111)Gat>Aat	p.D37N	RAD51_ENST00000532743.1_Missense_Mutation_p.D37N|RAD51_ENST00000557850.1_Missense_Mutation_p.D37N|RAD51_ENST00000423169.2_Missense_Mutation_p.D37N|RAD51_ENST00000382643.3_Missense_Mutation_p.D37N	NM_002875.4	NP_002866.2	Q06609	RAD51_HUMAN	RAD51 recombinase	37					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	9		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		AAATGCCAACGATGTGAAGAA	0.383000								Homologous recombination					10	44					0	0	0.008291	0	0
SDPR	8436	broad.mit.edu	37	2	192701173	192701173	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:192701173C>T	ENST00000304141.4	-	2	1083	c.754G>A	c.(754-756)Gag>Aag	p.E252K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	252						caveola|cytosol	phosphatidylserine binding|protein binding	p.E252*(1)		NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	ATCTTTTTCTCGATGTTCTGG	0.423000													84	186					0	0	0.014410	0	0
CDH7	1005	broad.mit.edu	37	18	63477229	63477229	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:63477229C>T	ENST00000536984.2	+	3	1194	c.500C>T	c.(499-501)cCc>cTc	p.P167L	CDH7_ENST00000397968.2_Missense_Mutation_p.P167L|CDH7_ENST00000323011.3_Missense_Mutation_p.P167L			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	167	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GAAATGTCTCCCGTGGGTAAG	0.398000													31	46					0	0	0.010818	0	0
IFNA7	3444	broad.mit.edu	37	9	21202054	21202054	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:21202054G>C	ENST00000239347.3	-	1	150	c.111C>G	c.(109-111)gcC>gcG	p.A37A		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	37					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGAGTATCAAGGCCCTCCTAT	0.502000													22	121					0	0	0.003330	0	0
AXIN1	8312	broad.mit.edu	37	16	339472	339472	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:339472G>C	ENST00000262320.3	-	10	2801	c.2430C>G	c.(2428-2430)ttC>ttG	p.F810L	AXIN1_ENST00000354866.3_Missense_Mutation_p.F774L	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	810	DIX.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GCAGCTCCTTGAACTGGCCCA	0.627000													13	52					0	0	0.002450	0	0
ANKRA2	57763	broad.mit.edu	37	5	72856967	72856967	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:72856967G>C	ENST00000296785.3	-	3	1094	c.436C>G	c.(436-438)Ctg>Gtg	p.L146V		NM_023039.4	NP_075526.1	Q9H9E1	ANRA2_HUMAN	ankyrin repeat, family A (RFXANK-like), 2	146						cytoskeleton|cytosol|membrane	low-density lipoprotein particle binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		Lung NSC(167;0.0378)|Ovarian(174;0.0908)		OV - Ovarian serous cystadenocarcinoma(47;3.71e-54)		TTTGCTAACAGAGGTGTGGTA	0.343000													11	34					0	0	0.002450	0	0
DSP	1832	broad.mit.edu	37	6	7578018	7578018	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:7578018G>C	ENST00000379802.3	+	21	3225	c.2884G>C	c.(2884-2886)Gag>Cag	p.E962Q	DSP_ENST00000418664.2_Missense_Mutation_p.E962Q	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	962	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCAGGATTATGAGCTCCAGCT	0.438000													5	93					0	0	0.000602	0	0
CHAC2	494143	broad.mit.edu	37	2	54001597	54001597	+	Missense_Mutation	SNP	C	C	G	rs34156607		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:54001597C>G	ENST00000295304.4	+	3	585	c.490C>G	c.(490-492)Ctt>Gtt	p.L164V	GPR75-ASB3_ENST00000394717.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron|GPR75-ASB3_ENST00000263634.3_Intron|ASB3_ENST00000406625.2_Intron|ASB3_ENST00000498475.2_Intron|GPR75-ASB3_ENST00000406687.1_Intron	NM_001008708.2	NP_001008708.1	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator homolog 2 (E. coli)	164										endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGATGAGCATCTTTTCGCTTT	0.348000													7	49					0	0	0.003080	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729766	37729766	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:37729766C>G	ENST00000330843.4	-	4	2566	c.2554G>C	c.(2554-2556)Gag>Cag	p.E852Q	RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	852					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCAGGAGGCTCTCCGTCAGAC	0.637000													7	40					0	0	0.006214	0	0
HECW2	57520	broad.mit.edu	37	2	197138838	197138838	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:197138838C>A	ENST00000260983.3	-	16	3327	c.3145G>T	c.(3145-3147)Gat>Tat	p.D1049Y	HECW2_ENST00000409111.1_Missense_Mutation_p.D693Y	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2		Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TGTCGAGAATCTTCTCCTACC	0.448000													14	24					0.000219431	0.000230032	0.002450	1	0
ZNF429	353088	broad.mit.edu	37	19	21719683	21719683	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:21719683G>A	ENST00000358491.4	+	4	1036	c.828G>A	c.(826-828)aaG>aaA	p.K276K	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	276				Missing (in Ref. 2; AAP30884 and 3; AAK01422).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						CTACCCATAAGAGAATTCATT	0.378000													4	35					0	0	0.009096	0	0
SLC25A47	283600	broad.mit.edu	37	14	100795778	100795778	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:100795778C>G	ENST00000361529.3	+	6	801	c.723C>G	c.(721-723)atC>atG	p.I241M	SLC25A47_ENST00000557052.1_Missense_Mutation_p.I95M	NM_207117.2	NP_997000.2	Q6Q0C1	S2547_HUMAN	solute carrier family 25, member 47	241					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	13						TGGACGTGATCAAGTCGAGAC	0.667000													9	58					0	0	0.004482	0	0
OSBP2	23762	broad.mit.edu	37	22	31289134	31289134	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:31289134C>T	ENST00000332585.6	+	9	1999	c.1895C>T	c.(1894-1896)gCg>gTg	p.A632V	OSBP2_ENST00000535268.1_Missense_Mutation_p.A176V|OSBP2_ENST00000407373.1_Missense_Mutation_p.A459V|OSBP2_ENST00000446658.2_Missense_Mutation_p.A631V|OSBP2_ENST00000403222.3_Missense_Mutation_p.A466V|OSBP2_ENST00000496575.1_Intron|OSBP2_ENST00000437268.2_Missense_Mutation_p.A374V|OSBP2_ENST00000382310.3_Missense_Mutation_p.A583V|OSBP2_ENST00000401475.1_Missense_Mutation_p.A265V	NM_001282739.1|NM_001282740.1|NM_001282741.1|NM_001282742.1|NM_030758.3	NP_001269668.1|NP_001269669.1|NP_001269670.1|NP_001269671.1|NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	632					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						CCCTCAGCTGCGCACTACGTG	0.592000													5	27					0	0	0.000602	0	0
INO80	54617	broad.mit.edu	37	15	41272569	41272569	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:41272569G>A	ENST00000361937.3	-	36	4947	c.4523C>T	c.(4522-4524)tCa>tTa	p.S1508L	INO80_ENST00000401393.3_Missense_Mutation_p.S1508L			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1508	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						AGAGGCGCTTGAAGGTCCAAA	0.547000													10	52					0	0	0.008291	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50475298	50475298	+	RNA	SNP	A	A	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:50475298A>C	ENST00000602139.1	+	0	1244									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						AGGAGAGTTCACCTGCCACGC	0.677000													4	30					0	0	0.008871	0	0
CNTRL	11064	broad.mit.edu	37	9	123932082	123932082	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:123932082G>C	ENST00000373855.1	+	39	6524	c.6264G>C	c.(6262-6264)gaG>gaC	p.E2088D	CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000238341.5_Missense_Mutation_p.E2088D|CNTRL_ENST00000373850.1_Missense_Mutation_p.E1536D			Q7Z7A1	CNTRL_HUMAN	centriolin	2088	Required for centrosome localization.|Sufficient for interaction with HOOK2.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GCCAGCTGGAGAAAAACCTTC	0.443000													3	81					0	0	0.004672	0	0
KCNC4	3749	broad.mit.edu	37	1	110765682	110765682	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:110765682G>C	ENST00000369787.3	+	2	802	c.775G>C	c.(775-777)Gag>Cag	p.E259Q	KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000413138.3_Missense_Mutation_p.E259Q|KCNC4_ENST00000438661.2_Missense_Mutation_p.E259Q	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	259					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.E259K(1)		central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAACGTGACAGAGATCCTCCG	0.552000													21	129					0	0	0.010504	0	0
DPM1	8813	broad.mit.edu	37	20	49574949	49574949	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:49574949C>G	ENST00000371582.4	-	1	143	c.112G>C	c.(112-114)Gag>Cag	p.E38Q	DPM1_ENST00000466152.1_5'UTR|DPM1_ENST00000371583.5_Missense_Mutation_p.E38Q|DPM1_ENST00000371588.5_Missense_Mutation_p.E38Q			O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	38					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	7						GGCAGGTTCTCGCGCTCGTTG	0.582000													16	25					0	0	0.004007	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89246952	89246952	+	RNA	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:89246952G>A	ENST00000496168.1	-	0	398																											TAAACTAGACGCCTTATAGAT	0.517000													38	101					0	0	0.004878	0	0
INPPL1	3636	broad.mit.edu	37	11	71949157	71949157	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:71949157C>G	ENST00000298229.2	+	27	3828	c.3624C>G	c.(3622-3624)atC>atG	p.I1208M	INPPL1_ENST00000538751.1_Missense_Mutation_p.I966M|INPPL1_ENST00000541756.1_Missense_Mutation_p.I966M	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1208	SAM.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TGCGGGCCATCGGCTTGGAGC	0.711000											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	21					0	0	0.004672	0	0
TWSG1	57045	broad.mit.edu	37	18	9396405	9396405	+	Silent	SNP	C	C	T	rs143807731		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:9396405C>T	ENST00000262120.5	+	4	542	c.351C>T	c.(349-351)aaC>aaT	p.N117N	TWSG1_ENST00000581641.1_Silent_p.N117N	NM_020648.5	NP_065699.1	Q9GZX9	TWSG1_HUMAN	twisted gastrulation BMP signaling modulator 1	117										breast(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|pancreas(2)	10						TGAATTGGAACATCGTTTCTT	0.463000													14	92					0	0	0.004007	0	0
MCC	4163	broad.mit.edu	37	5	112363128	112363128	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:112363128C>T	ENST00000302475.4	-	17	2924	c.2361G>A	c.(2359-2361)ctG>ctA	p.L787L	MCC_ENST00000514701.3_5'UTR|MCC_ENST00000515367.2_Silent_p.L724L|MCC_ENST00000408903.3_Silent_p.L977L	NM_002387.2	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers	787					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTAACTTCTTCAGTTTGTTTT	0.448000													6	82					0	0	0.001984	0	0
LRRC71	149499	broad.mit.edu	37	1	156897392	156897392	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:156897392C>T	ENST00000337428.7	+	7	921	c.767C>T	c.(766-768)tCg>tTg	p.S256L	LRRC71_ENST00000490146.1_3'UTR	NM_144702.2	NP_653303.2	Q8N4P6	LRC71_HUMAN	leucine rich repeat containing 71	256										endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|stomach(1)	12						ACCCTCGTCTCGCTCAACCTG	0.662000											OREG0013892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	9					0	0	0.010729	0	0
STAB1	23166	broad.mit.edu	37	3	52554987	52554987	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:52554987C>A	ENST00000321725.6	+	55	5950	c.5874C>A	c.(5872-5874)agC>agA	p.S1958R		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1958					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGAAGCCCAGCTGCTGCCCTG	0.617000													12	17					3.07112e-06	3.25884e-06	0.010729	1	0
PTCHD1	139411	broad.mit.edu	37	X	23412194	23412194	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:23412194G>C	ENST00000379361.4	+	3	3419	c.2559G>C	c.(2557-2559)aaG>aaC	p.K853N		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	853					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						CACCCTCTAAGAAAAAAAGGA	0.403000													38	78					0	0	0.006230	0	0
NTRK3	4916	broad.mit.edu	37	15	88476307	88476307	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:88476307C>T	ENST00000394480.2	-	16	2146	c.1825G>A	c.(1825-1827)Gat>Aat	p.D609N	NTRK3_ENST00000360948.2_Missense_Mutation_p.D609N|NTRK3_ENST00000355254.2_Missense_Mutation_p.D609N|NTRK3_ENST00000557856.1_Missense_Mutation_p.D601N|NTRK3_ENST00000542733.2_Missense_Mutation_p.D511N|NTRK3_ENST00000357724.2_Missense_Mutation_p.D601N|NTRK3_ENST00000558676.1_Missense_Mutation_p.D601N	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3		Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGTCCCCATCGCCGCACACT	0.552000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			6	46					0	0	0.001168	0	0
DAZAP2	9802	broad.mit.edu	37	12	51636147	51636147	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:51636147C>G	ENST00000549555.1	+	4	419	c.335C>G	c.(334-336)tCa>tGa	p.S112*	DAZAP2_ENST00000551534.1_3'UTR|DAZAP2_ENST00000604900.1_Intron|DAZAP2_ENST00000439799.2_Missense_Mutation_p.Q56E|DAZAP2_ENST00000551313.1_Missense_Mutation_p.Q78E|DAZAP2_ENST00000549732.2_Missense_Mutation_p.Q106E|DAZAP2_ENST00000449723.3_Missense_Mutation_p.Q116E|DAZAP2_ENST00000425012.2_Intron|DAZAP2_ENST00000412716.3_Missense_Mutation_p.Q138E	NM_001136266.1	NP_001129738.1	Q15038	DAZP2_HUMAN	DAZ associated protein 2	0	Pro-rich.						WW domain binding			haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)	6						CAATGCTGCTCAGCTTGCAGT	0.537000													7	333					0	0	0.001984	0	0
BMI1	648	broad.mit.edu	37	10	22616526	22616526	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:22616526C>G	ENST00000376663.3	+	4	717	c.212C>G	c.(211-213)tCa>tGa	p.S71*	COMMD3-BMI1_ENST00000602390.1_Nonsense_Mutation_p.S214*	NM_005180.8	NP_005171.4			BMI1 polycomb ring finger oncogene											breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|urinary_tract(1)	12						TTTTTCAGGTCAGATAAAACT	0.264000													13	121					0	0	0.001855	0	0
POLA2	23649	broad.mit.edu	37	11	65063047	65063047	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:65063047C>G	ENST00000265465.3	+	16	2028	c.1497C>G	c.(1495-1497)ctC>ctG	p.L499L	POLA2_ENST00000541089.1_Silent_p.L291L|POLA2_ENST00000534785.1_3'UTR	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	499					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	GCCGAATACTCAAGCACATCT	0.498000													10	130					0	0	0.010729	0	0
PNMA5	114824	broad.mit.edu	37	X	152159943	152159943	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:152159943A>G	ENST00000439251.1	-	2	638	c.200T>C	c.(199-201)aTt>aCt	p.I67T	PNMA5_ENST00000535214.1_Missense_Mutation_p.I67T|PNMA5_ENST00000452693.1_Missense_Mutation_p.I67T|PNMA5_ENST00000361887.5_Missense_Mutation_p.I67T	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	67					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					agccagttcaatgaagactgc	0.517000													29	117					0	0	0.006320	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128671	45128671	+	RNA	SNP	T	T	G	rs1056072	by1000genomes	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:45128671T>G	ENST00000575173.1	-	0	418																											GCTCACAAAATAAGTTCCAGG	0.323000													3	121					0	0	0.009096	0	0
CRYGB	1419	broad.mit.edu	37	2	209007482	209007482	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:209007482C>G	ENST00000260988.4	-	3	455	c.408G>C	c.(406-408)gaG>gaC	p.E136D		NM_005210.3	NP_005201.2	P07316	CRGB_HUMAN	crystallin, gamma B	136	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens	p.E136E(1)		cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)	14				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		AGTTGGGCATCTCATAGAGGA	0.542000													34	81					0	0	0.004289	0	0
PKD1L1	168507	broad.mit.edu	37	7	47876633	47876633	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:47876633G>A	ENST00000289672.2	-	37	5879	c.5829C>T	c.(5827-5829)taC>taT	p.Y1943Y		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1943					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGGGCCTGCTGTACACCGACA	0.577000													3	43					0	0	0.009096	0	0
PCYT2	5833	broad.mit.edu	37	17	79864646	79864646	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:79864646G>A	ENST00000538936.2	-	7	774	c.666C>T	c.(664-666)ttC>ttT	p.F222F	PCYT2_ENST00000570391.1_Silent_p.F190F|PCYT2_ENST00000570388.1_Silent_p.F144F|PCYT2_ENST00000538721.2_Silent_p.F240F|PCYT2_ENST00000331285.3_Silent_p.F144F|PCYT2_ENST00000571105.1_Silent_p.F222F	NM_001256435.1|NM_002861.3	NP_001243364.1|NP_002852.1	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	222	Catalytic 2 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity			breast(2)|endometrium(1)|lung(4)|ovary(1)	8	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GGAACAGGTCGAAGGCACCAG	0.607000													16	32					0	0	0.006122	0	0
ANK2	287	broad.mit.edu	37	4	114275389	114275389	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:114275389C>T	ENST00000357077.4	+	38	5668	c.5615C>T	c.(5614-5616)tCg>tTg	p.S1872L	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S1839L|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1839	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCGTCATCATCGAGTAAAACT	0.453000													34	107					0	0	0.003271	0	0
ASAP2	8853	broad.mit.edu	37	2	9419502	9419502	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:9419502C>G	ENST00000281419.3	+	2	523	c.183C>G	c.(181-183)atC>atG	p.I61M	ASAP2_ENST00000315273.4_Missense_Mutation_p.I61M	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	61					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						TGAAAGCAATCAACAGCTCTG	0.428000													23	35					0	0	0.005443	0	0
FAT3	120114	broad.mit.edu	37	11	92523337	92523337	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:92523337G>A	ENST00000298047.6	+	7	4581	c.4564G>A	c.(4564-4566)Gag>Aag	p.E1522K	FAT3_ENST00000525166.1_Missense_Mutation_p.E1372K|FAT3_ENST00000409404.2_Missense_Mutation_p.E1522K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1522	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTATACTGCCGAGAGGCTGGA	0.498000										TCGA Ovarian(4;0.039)			21	117					0	0	0.008871	0	0
ZNF266	10781	broad.mit.edu	37	19	9526415	9526415	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:9526415G>T	ENST00000592904.1	-	4	2195	c.119C>A	c.(118-120)tCa>tAa	p.S40*	ZNF266_ENST00000588933.1_Nonsense_Mutation_p.S40*|ZNF266_ENST00000588221.1_Nonsense_Mutation_p.S40*|ZNF266_ENST00000592292.1_Nonsense_Mutation_p.S40*|ZNF266_ENST00000590306.1_Nonsense_Mutation_p.S40*|ZNF266_ENST00000361151.1_Nonsense_Mutation_p.S40*|ZNF266_ENST00000361451.2_Nonsense_Mutation_p.S40*			Q14584	ZN266_HUMAN	zinc finger protein 266	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|large_intestine(11)|lung(8)|ovary(1)|skin(2)|stomach(1)	28						TTTCCATTCTGAAGCTGAAGA	0.408000													13	25					4.3838e-07	4.6977e-07	0.001855	1	0
ARHGAP29	9411	broad.mit.edu	37	1	94639451	94639451	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:94639451C>T	ENST00000260526.6	-	23	3942	c.3760G>A	c.(3760-3762)Gaa>Aaa	p.E1254K		NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	1254					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATTTCACCTTCGAGGTCTTCA	0.398000													13	106					0	0	0.001855	0	0
ACP6	51205	broad.mit.edu	37	1	147124427	147124427	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:147124427G>A	ENST00000392988.2	-	7	997	c.804C>T	c.(802-804)ttC>ttT	p.F268F	ACP6_ENST00000369238.6_Intron			Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	0					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					AGCTTCCATGGAACCTGCAGG	0.478000													4	60					0	0	0.009096	0	0
C11orf48	79081	broad.mit.edu	37	11	62435136	62435136	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:62435136C>G	ENST00000431002.2	-	2	2208	c.475G>C	c.(475-477)Gaa>Caa	p.E159Q	METTL12_ENST00000532971.1_3'UTR|C11orf48_ENST00000354588.3_Missense_Mutation_p.E133Q|C11orf48_ENST00000532208.1_Missense_Mutation_p.E133Q			Q9BQE6	CK048_HUMAN	chromosome 11 open reading frame 48	159										endometrium(1)|lung(5)|urinary_tract(1)	7						CAAGCATCTTCTTCATCCTGG	0.537000													14	315					0	0	0.002450	0	0
PHACTR1	221692	broad.mit.edu	37	6	13182825	13182825	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:13182825C>T	ENST00000379350.1	+	6	700	c.571C>T	c.(571-573)Ctg>Ttg	p.L191L	PHACTR1_ENST00000457702.2_Silent_p.L46L|PHACTR1_ENST00000379345.2_Silent_p.L46L|PHACTR1_ENST00000332995.7_Silent_p.L191L			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	191						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CCAGCTGTCTCTGCCTGCCCT	0.542000													4	228					0	0	0.009096	0	0
ZNF45	7596	broad.mit.edu	37	19	44418218	44418218	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:44418218G>C	ENST00000269973.5	-	10	2460	c.1370C>G	c.(1369-1371)tCa>tGa	p.S457*	ZNF45_ENST00000589703.1_Nonsense_Mutation_p.S457*|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	457					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						CAGAAGATTTGAGGCCTGGCT	0.473000													5	125					0	0	0.001168	0	0
LINGO4	339398	broad.mit.edu	37	1	151774212	151774212	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:151774212C>T	ENST00000368820.3	-	2	1906	c.969G>A	c.(967-969)ttG>ttA	p.L323L		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	323						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAGGCAGTCAAGCCATGGA	0.597000													13	71					0	0	0.013537	0	0
CYP26A1	1592	broad.mit.edu	37	10	94834560	94834560	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:94834560G>A	ENST00000371531.1	+	3	610	c.232G>A	c.(232-234)Gag>Aag	p.E78K	CYP26A1_ENST00000224356.4_Missense_Mutation_p.E147K|CYP26A1_ENST00000394139.1_Missense_Mutation_p.E78K	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	147					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				CTTCAGCCGCGAGGCACTCGA	0.657000													10	16					0	0	0.010729	0	0
ZWINT	11130	broad.mit.edu	37	10	58118398	58118398	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:58118398A>T	ENST00000373944.3	-	7	749	c.711T>A	c.(709-711)gaT>gaA	p.D237E	ZWINT_ENST00000460654.1_5'UTR|ZWINT_ENST00000395405.1_Missense_Mutation_p.D237E|ZWINT_ENST00000361148.6_Missense_Mutation_p.D190E|ZWINT_ENST00000318387.2_Missense_Mutation_p.D117E			O95229	ZWINT_HUMAN	ZW10 interacting kinetochore protein	237					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)	20						GGGGTTTATCATCTGGAAGAT	0.532000													18	27					0	0	0.006122	0	0
STRADA	92335	broad.mit.edu	37	17	61787963	61787963	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:61787963C>G	ENST00000245865.5	-	7	504	c.295G>C	c.(295-297)Gat>Cat	p.D99H	RP11-51F16.8_ENST00000580553.1_Intron|STRADA_ENST00000392950.4_Missense_Mutation_p.D120H|STRADA_ENST00000447001.3_Missense_Mutation_p.D113H|STRADA_ENST00000582137.1_Missense_Mutation_p.D128H|STRADA_ENST00000336174.6_Missense_Mutation_p.D157H|STRADA_ENST00000580039.1_5'UTR|STRADA_ENST00000579340.1_Missense_Mutation_p.D99H|STRADA_ENST00000375840.4_Missense_Mutation_p.D99H			Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha	157	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(2)	13						CAGATGAGATCTTTTGCAGAA	0.498000													6	35					0	0	0.001168	0	0
POTEC	388468	broad.mit.edu	37	18	14513681	14513681	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:14513681C>T	ENST00000358970.5	-	10	1512	c.1513G>A	c.(1513-1515)Gaa>Aaa	p.E505K		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	505										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						ATTTTCTTTTCAGCCACTTCT	0.299000													15	60					0	0	0.003163	0	0
ISOC1	51015	broad.mit.edu	37	5	128440990	128440990	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:128440990C>T	ENST00000173527.5	+	3	558	c.542C>T	c.(541-543)cCa>cTa	p.P181L		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	181						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		CTGGTACTTCCAAAGACCAAG	0.398000													9	25					0	0	0.004482	0	0
UGT1A3	54659	broad.mit.edu	37	2	234637776	234637776	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:234637776G>A	ENST00000482026.1	+	1	23	c.4G>A	c.(4-6)Gcc>Acc	p.A2T	UGT1A1_ENST00000609637.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A1_ENST00000609767.1_Missense_Mutation_p.A2T|UGT1A9_ENST00000354728.4_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A1_ENST00000608381.1_Intron|UGT1A6_ENST00000406651.1_Intron																breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TGCTGAGATGGCCACAGGACT	0.572000											OREG0003835	type=REGULATORY REGION|Gene=UGT1A3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	72					0	0	0.004672	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132905741	132905741	+	Missense_Mutation	SNP	G	G	A	rs111770980	by1000genomes	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:132905741G>A	ENST00000409867.1	-	6	989	c.740C>T	c.(739-741)aCg>aTg	p.T247M	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						GCTTTCAGCCGTGTCAGGTGT	0.438000													4	21					0	0	0.001168	0	0
LCE3A	353142	broad.mit.edu	37	1	152595518	152595518	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:152595518G>T	ENST00000335674.1	-	1	61	c.62C>A	c.(61-63)cCa>cAa	p.P21Q		NM_178431.1	NP_848518.1	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	21					keratinization					endometrium(1)|lung(5)	6	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACACTGTGCTGGGCTCTTTGC	0.632000													22	47					4.4004e-07	4.70388e-07	0.003330	1	0
OR4L1	122742	broad.mit.edu	37	14	20528789	20528789	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:20528789G>A	ENST00000315683.1	+	1	586	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATACACCCTGGAATTATTTGT	0.408000													59	80					0	0	0.014410	0	0
FGF6	2251	broad.mit.edu	37	12	4553375	4553375	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:4553375C>T	ENST00000228837.2	-	2	417	c.374G>A	c.(373-375)cGa>cAa	p.R125Q		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	125					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity	p.R125Q(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			CACCACGCCTCGCTCCACAGT	0.537000													9	36					0	0	0.010729	0	0
STARD10	10809	broad.mit.edu	37	11	72469670	72469670	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:72469670G>C	ENST00000334805.6	-	4	1283	c.364C>G	c.(364-366)Ccc>Gcc	p.P122A	ARAP1_ENST00000359373.5_Intron|STARD10_ENST00000545082.1_Missense_Mutation_p.P93A|STARD10_ENST00000538536.1_Missense_Mutation_p.P76A|STARD10_ENST00000538437.1_5'UTR|STARD10_ENST00000543304.1_Missense_Mutation_p.P122A	NM_006645.2	NP_006636.2	Q9Y365	PCTL_HUMAN	StAR-related lipid transfer (START) domain containing 10	122	START.									endometrium(4)|large_intestine(1)|lung(2)|prostate(1)	8			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			AGGGGCTTGGGACACCTCCCT	0.582000													3	19					0	0	0.004672	0	0
CACNA1C	775	broad.mit.edu	37	12	2797760	2797760	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:2797760G>A	ENST00000399655.1	+	46	6197	c.5932G>A	c.(5932-5934)Gag>Aag	p.E1978K	CACNA1C_ENST00000399634.1_Missense_Mutation_p.E2049K|CACNA1C_ENST00000399595.1_Missense_Mutation_p.E1986K|CACNA1C_ENST00000399621.1_Missense_Mutation_p.E1997K|CACNA1C_ENST00000344100.3_Missense_Mutation_p.E2019K|CACNA1C_ENST00000399637.1_Missense_Mutation_p.E1997K|CACNA1C_ENST00000399617.1_Missense_Mutation_p.E2013K|CACNA1C_ENST00000335762.5_Missense_Mutation_p.E2003K|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399641.1_Missense_Mutation_p.E1978K|CACNA1C_ENST00000399629.1_Missense_Mutation_p.E1995K|CACNA1C_ENST00000399606.1_Missense_Mutation_p.E1998K|CACNA1C_ENST00000399649.1_Missense_Mutation_p.E1984K|CACNA1C_ENST00000399597.1_Missense_Mutation_p.E1978K|CACNA1C_ENST00000327702.7_Missense_Mutation_p.E2013K|CACNA1C_ENST00000399603.1_Missense_Mutation_p.E1978K|CACNA1C_ENST00000399638.1_Missense_Mutation_p.E2006K|CACNA1C_ENST00000406454.3_Missense_Mutation_p.E2049K|CACNA1C_ENST00000399644.1_Missense_Mutation_p.E1978K|CACNA1C_ENST00000399591.1_Missense_Mutation_p.E1986K|CACNA1C_ENST00000399601.1_Missense_Mutation_p.E1978K|CACNA1C_ENST00000402845.3_Missense_Mutation_p.E1997K|CACNA1C_ENST00000347598.4_Missense_Mutation_p.E2026K	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	2061					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGAGGGGGTCGAGTCCAGTGA	0.692000													13	53					0	0	0.013537	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68273295	68273295	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:68273295C>G	ENST00000347230.4	-	6	1122	c.984G>C	c.(982-984)ctG>ctC	p.L328L	ZFYVE26_ENST00000555452.1_Silent_p.L328L	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	328					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGTTGTTGCTCAGGCAGTAGA	0.498000													7	34					0	0	0.001984	0	0
SGK223	157285	broad.mit.edu	37	8	8175696	8175696	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:8175696T>A	ENST00000520004.1	-	6	4453	c.4189A>T	c.(4189-4191)Aag>Tag	p.K1397*	SGK223_ENST00000330777.4_Nonsense_Mutation_p.K1397*			Q86YV5	SG223_HUMAN		1397							ATP binding|non-membrane spanning protein tyrosine kinase activity										TGCAGGAGCTTCAGCGACTGT	0.657000													8	29					0	0	0.003080	0	0
PCLO	27445	broad.mit.edu	37	7	82544005	82544005	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:82544005C>G	ENST00000333891.9	-	7	13634	c.13297G>C	c.(13297-13299)Gaa>Caa	p.E4433Q	PCLO_ENST00000423517.2_Missense_Mutation_p.E4433Q|PCLO_ENST00000437081.1_Missense_Mutation_p.E1153Q	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein		PDZ.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AATTTACCTTCACTGTCTGAC	0.418000													5	20					0	0	0.000602	0	0
SLC7A2	6542	broad.mit.edu	37	8	17401171	17401171	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:17401171G>C	ENST00000470360.1	+	4	560	c.443G>C	c.(442-444)gGa>gCa	p.G148A	SLC7A2_ENST00000398090.3_Missense_Mutation_p.G148A|SLC7A2_ENST00000494857.1_Missense_Mutation_p.G108A|SLC7A2_ENST00000004531.10_Missense_Mutation_p.G148A|SLC7A2_ENST00000522656.1_Missense_Mutation_p.G108A			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	108					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	GTGACTGTCGGAGAGCTGTGG	0.493000													18	28					0	0	0.008871	0	0
CLUH	23277	broad.mit.edu	37	17	2605236	2605236	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:2605236C>G	ENST00000570628.2	-	4	582	c.477G>C	c.(475-477)ctG>ctC	p.L159L	CLUH_ENST00000538975.1_Silent_p.L159L|CLUH_ENST00000435359.1_Silent_p.L159L					clustered mitochondria (cluA/CLU1) homolog																		TGAAGACACTCAGGAAGGACA	0.667000													6	42					0	0	0.004482	0	0
ADAM23	8745	broad.mit.edu	37	2	207437917	207437917	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:207437917C>G	ENST00000264377.3	+	18	2063	c.1735C>G	c.(1735-1737)Cag>Gag	p.Q579E	ADAM23_ENST00000374416.1_Missense_Mutation_p.Q579E|ADAM23_ENST00000374415.3_Missense_Mutation_p.Q579E	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	579	Disintegrin.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AGACTCTGGTCAGGTATGGCG	0.408000													27	63					0	0	0.006320	0	0
C11orf30	56946	broad.mit.edu	37	11	76257114	76257114	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:76257114G>A	ENST00000529032.1	+	19	3547	c.3547G>A	c.(3547-3549)Gaa>Aaa	p.E1183K	C11orf30_ENST00000343878.3_Intron|C11orf30_ENST00000525038.1_Missense_Mutation_p.E1184K|C11orf30_ENST00000525919.1_Missense_Mutation_p.E1184K|C11orf30_ENST00000334736.3_Missense_Mutation_p.E1183K|C11orf30_ENST00000524767.1_Missense_Mutation_p.E1198K|C11orf30_ENST00000524490.1_Missense_Mutation_p.E1085K|C11orf30_ENST00000533248.1_Missense_Mutation_p.E1092K			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1183					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						GCTCACTGGTGAAGCAGGATC	0.478000													14	46					0	0	0.003163	0	0
SNORD3A	780851	broad.mit.edu	37	17	19091408	19091408	+	RNA	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:19091408G>A	ENST00000365494.1	+	0	80																											cgaaaaccacgaggaagagag	0.493000													54	244					0	0	0.014410	0	0
CATSPERD	257062	broad.mit.edu	37	19	5771022	5771022	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:5771022C>G	ENST00000381624.3	+	19	1763	c.1702C>G	c.(1702-1704)Cag>Gag	p.Q568E	CATSPERD_ENST00000381614.2_Missense_Mutation_p.Q226E|CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	568						integral to membrane											TTACTCCTACCAGCAGCTGGG	0.607000													13	50					0	0	0.013537	0	0
GGT6	124975	broad.mit.edu	37	17	4461953	4461953	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:4461953C>T	ENST00000301395.3	-	3	802	c.743G>A	c.(742-744)gGa>gAa	p.G248E	GGT6_ENST00000381550.3_Missense_Mutation_p.G286E|GGT6_ENST00000573591.1_Missense_Mutation_p.G132E|GGT6_ENST00000574154.1_Missense_Mutation_p.G280E	NM_153338.2	NP_699169.2	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6	280					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						CCCCAGGTCTCCCGCCAGTAG	0.657000													17	5					0	0	0.006122	0	0
NPIPA1	9284	broad.mit.edu	37	16	15045813	15045813	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:15045813C>G	ENST00000328085.6	+	8	984	c.984C>G	c.(982-984)ctC>ctG	p.L328L	NPIPA1_ENST00000472413.1_3'UTR	NM_006985.2	NP_008916.2			nuclear pore complex interacting protein family, member A1																		ATGATAATCTCAAGACACCTC	0.468000													4	60					0	0	0.001168	0	0
LMO4	8543	broad.mit.edu	37	1	87797721	87797721	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:87797721C>T	ENST00000370544.5	+	2	803	c.23C>T	c.(22-24)tCg>tTg	p.S8L	LMO4_ENST00000370542.1_Missense_Mutation_p.S8L|LMO4_ENST00000489303.1_3'UTR	NM_006769.3	NP_006760.1	P61968	LMO4_HUMAN	LIM domain only 4	8					neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(1)	9		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		GGCAGCAGCTCGCAGCCGCCC	0.637000													6	53					0	0	0.003080	0	0
COL6A3	1293	broad.mit.edu	37	2	238262009	238262009	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:238262009C>G	ENST00000295550.4	-	25	7117	c.6665G>C	c.(6664-6666)gGa>gCa	p.G2222A	COL6A3_ENST00000409809.1_Missense_Mutation_p.G2016A|COL6A3_ENST00000353578.4_Missense_Mutation_p.G2016A|COL6A3_ENST00000346358.4_Missense_Mutation_p.G2022A|COL6A3_ENST00000347401.3_Missense_Mutation_p.G2021A|COL6A3_ENST00000472056.1_Missense_Mutation_p.G1615A	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2222	Collagen-like 3.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCCCTGCTCTCCCTCAAAGCC	0.507000													10	44					0	0	0.013537	0	0
RFTN2	130132	broad.mit.edu	37	2	198508944	198508944	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:198508944C>A	ENST00000295049.4	-	3	912	c.376G>T	c.(376-378)Gag>Tag	p.E126*		NM_144629.2	NP_653230.2	Q52LD8	RFTN2_HUMAN	raftlin family member 2							plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(13)|urinary_tract(3)	30						GGACATTCCTCAATCACGAGC	0.433000													10	39					6.40141e-05	6.74323e-05	0.010729	1	0
SMYD3	64754	broad.mit.edu	37	1	246021899	246021899	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:246021899G>C	ENST00000490107.1	-	10	1014	c.798C>G	c.(796-798)atC>atG	p.I266M	SMYD3_ENST00000541742.1_Missense_Mutation_p.I266M|SMYD3_ENST00000366517.1_5'UTR|SMYD3_ENST00000388985.4_Missense_Mutation_p.I325M	NM_001167740.1	NP_001161212.1	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	325						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			breast(3)|large_intestine(5)|lung(8)|skin(1)	17	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		TCAGCTGGTAGATGTTGATAT	0.507000													4	61					0	0	0.009096	0	0
RIN1	9610	broad.mit.edu	37	11	66100213	66100213	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:66100213C>T	ENST00000311320.4	-	10	2012	c.1886G>A	c.(1885-1887)cGa>cAa	p.R629Q	RIN1_ENST00000424433.2_Missense_Mutation_p.R524Q|RIN1_ENST00000530056.1_Missense_Mutation_p.R463Q|RIN1_ENST00000524804.1_5'UTR	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	629	Ras and 14-3-3 protein binding region.|Ras-associating.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						ATAGGCTACTCGGAGGAGGTG	0.592000													11	84					0	0	0.008291	0	0
RFPL1	5988	broad.mit.edu	37	22	29834919	29834919	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:29834919C>G	ENST00000354373.2	+	1	348	c.139C>G	c.(139-141)Cta>Gta	p.L47V	RFPL1S_ENST00000461286.3_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	47							zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						CTCAGACTATCTAGAGAAACC	0.517000													14	74					0	0	0.001855	0	0
TENM2	57451	broad.mit.edu	37	5	167626878	167626878	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:167626878G>A	ENST00000519204.1	+	16	2927	c.2809G>A	c.(2809-2811)Gaa>Aaa	p.E937K	TENM2_ENST00000403607.2_Missense_Mutation_p.E882K|TENM2_ENST00000520394.1_Missense_Mutation_p.E826K|TENM2_ENST00000518659.1_Missense_Mutation_p.E1058K|TENM2_ENST00000545108.1_Missense_Mutation_p.E1058K					teneurin transmembrane protein 2																		GGTTCTTCATGAAGAAATCGA	0.488000													79	118					0	0	0.014410	0	0
ANKHD1	54882	broad.mit.edu	37	5	139876702	139876702	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:139876702C>G	ENST00000297183.6	+	15	2967	c.2843C>G	c.(2842-2844)tCt>tGt	p.S948C	ANKHD1_ENST00000462121.1_3'UTR|ANKHD1_ENST00000360839.2_Missense_Mutation_p.S948C|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.S948C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGACAAATTCTCTTGAACTT	0.428000													4	84					0	0	0.009096	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34802629	34802629	+	Silent	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:34802629C>G	ENST00000192788.5	+	6	831	c.660C>G	c.(658-660)ctC>ctG	p.L220L	UHRF1BP1_ENST00000452449.2_Silent_p.L220L	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	220										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						AAATAGCCCTCAAAAGAAGAG	0.438000													3	73					0	0	0.009096	0	0
CELSR3	1951	broad.mit.edu	37	3	48698212	48698212	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:48698212C>T	ENST00000544264.1	-	1	2136	c.1856G>A	c.(1855-1857)cGc>cAc	p.R619H	CELSR3_ENST00000164024.4_Missense_Mutation_p.R619H			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	619	Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGCCCTGATGCGCAAGGCATA	0.587000													6	25					0	0	0.001168	0	0
CFH	3075	broad.mit.edu	37	1	196694341	196694341	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:196694341C>A	ENST00000367429.4	+	12	2027	c.1787C>A	c.(1786-1788)tCc>tAc	p.S596Y		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	596	Sushi 10.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TTGAAATTCTCCTGCAAACCA	0.393000													7	41					0.00307968	0.00320523	0.003080	1	0
EVI2B	2124	broad.mit.edu	37	17	29632630	29632630	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:29632630C>T	ENST00000544462.1	-	3	197	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	CTD-2370N5.3_ENST00000578584.1_3'UTR|NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron|EVI2B_ENST00000577894.1_5'UTR|EVI2B_ENST00000330927.4_5'UTR			P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	0						cytoplasm|integral to plasma membrane		p.0?(8)|p.?(3)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	12		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		GGATCCATTTCAGAATATTTC	0.323000													7	31					0	0	0.003080	0	0
TDP1	55775	broad.mit.edu	37	14	90442142	90442142	+	Silent	SNP	G	G	A	rs139270583	byFrequency	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:90442142G>A	ENST00000335725.4	+	7	1024	c.774G>A	c.(772-774)gcG>gcA	p.A258A	TDP1_ENST00000555880.1_Silent_p.A258A|TDP1_ENST00000393454.2_Silent_p.A258A|TDP1_ENST00000357382.3_Intron|TDP1_ENST00000393452.3_Silent_p.A258A|TDP1_ENST00000555565.1_3'UTR	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	258					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGATATTGCGTTTGGAACAC	0.373000								Repair of DNA-protein crosslinks					18	98					0	0	0.006122	0	0
SLC9A4	389015	broad.mit.edu	37	2	103128724	103128724	+	Silent	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:103128724G>C	ENST00000295269.4	+	7	2008	c.1551G>C	c.(1549-1551)gtG>gtC	p.V517V		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	517					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						ACTACCAAGTGAGAGACAAGT	0.453000													20	79					0	0	0.010504	0	0
FOXO4	4303	broad.mit.edu	37	X	70321316	70321316	+	Silent	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:70321316C>A	ENST00000374259.3	+	2	1568	c.1236C>A	c.(1234-1236)gtC>gtA	p.V412V	FOXO4_ENST00000341558.3_Silent_p.V357V	NM_001170931.1|NM_005938.3	NP_001164402.1|NP_005929.2	P98177	FOXO4_HUMAN	forkhead box O4	412					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)	18	Renal(35;0.156)					CCACGGGCGTCGGCCTGTGTC	0.617000													6	29					0.00116845	0.001219	0.001168	1	0
NUP85	79902	broad.mit.edu	37	17	73204673	73204673	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:73204673C>G	ENST00000245544.4	+	2	156	c.85C>G	c.(85-87)Cca>Gca	p.P29A	NUP85_ENST00000449421.2_Intron|NUP85_ENST00000579298.1_Missense_Mutation_p.P29A|NUP85_ENST00000447371.2_5'UTR|NUP85_ENST00000541827.1_Intron|NUP85_ENST00000579324.1_Intron	NM_024844.3	NP_079120.1	Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	29					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			TGACTGGGGTCCAGGGGAGAT	0.358000													6	241					0	0	0.001984	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970821	101970821	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:101970821C>T	ENST00000543253.1	+	5	1943	c.1024C>T	c.(1024-1026)Cct>Tct	p.P342S	GPRASP2_ENST00000332262.5_Missense_Mutation_p.P342S|GPRASP2_ENST00000535209.1_Missense_Mutation_p.P342S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						CTGGGTTTTGCCTGGAGAAGA	0.448000													4	116					0	0	0.009096	0	0
DAW1	164781	broad.mit.edu	37	2	228771965	228771965	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:228771965G>C	ENST00000373666.2	+	10	1606	c.970G>C	c.(970-972)Gat>Cat	p.D324H	DAW1_ENST00000309931.2_Missense_Mutation_p.D324H|DAW1_ENST00000545118.1_Missense_Mutation_p.D309H					dynein assembly factor with WDR repeat domains 1																		TGCTTCAGCTGATGGTAGGTG	0.373000													5	21					0	0	0.000602	0	0
BRF1	2972	broad.mit.edu	37	14	105688029	105688029	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:105688029G>A	ENST00000546474.1	-	11	16230	c.1271C>T	c.(1270-1272)tCa>tTa	p.S424L	BRF1_ENST00000440513.3_Missense_Mutation_p.S309L|BRF1_ENST00000392557.4_Missense_Mutation_p.S220L|BRF1_ENST00000327359.3_Missense_Mutation_p.S309L|BRF1_ENST00000379937.2_Missense_Mutation_p.S397L|BRF1_ENST00000551787.1_Intron|BRF1_ENST00000379932.4_Intron|BRF1_ENST00000446501.2_Missense_Mutation_p.S186L|BRF1_ENST00000547530.1_5'UTR	NM_001242787.1|NM_001519.3	NP_001229716.1|NP_001510.2	Q92994	TF3B_HUMAN	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	424					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		GATGGAGTCTGAGATGCCCAG	0.672000													6	19					0	0	0.001984	0	0
TMEM50A	23585	broad.mit.edu	37	1	25678163	25678163	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:25678163G>A	ENST00000374358.4	+	4	806	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	TMEM50A_ENST00000480937.1_3'UTR	NM_014313.3	NP_055128.1	O95807	TM50A_HUMAN	transmembrane protein 50A	85						endoplasmic reticulum|integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)		TAGTTACAGTGAAGGTTGTCT	0.368000													13	40					0	0	0.001855	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6335373	6335373	+	Silent	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:6335373G>A	ENST00000335585.5	-	7	899	c.876C>T	c.(874-876)agC>agT	p.S292S	PPP2R2C_ENST00000515571.1_Silent_p.S275S|PPP2R2C_ENST00000506140.1_Silent_p.S285S|PPP2R2C_ENST00000507294.1_Silent_p.S285S|PPP2R2C_ENST00000382599.4_Silent_p.S292S	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	292					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						TGTAGCGGCCGCTGTGGCTGA	0.562000											OREG0016071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	82					0	0	0.008871	0	0
VPS13D	55187	broad.mit.edu	37	1	12317111	12317111	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:12317111G>A	ENST00000358136.3	+	9	1038	c.908G>A	c.(907-909)cGa>cAa	p.R303Q	VPS13D_ENST00000356315.4_Missense_Mutation_p.R303Q	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	303					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GTGAAGTTCCGAAGGTGGAAA	0.443000													3	67					0	0	0.004672	0	0
RPGR	6103	broad.mit.edu	37	X	38150241	38150241	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:38150241A>C	ENST00000378505.2	-	13	1719	c.1543T>G	c.(1543-1545)Tta>Gta	p.L515V	RPGR_ENST00000338898.3_3'UTR|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000342811.3_Missense_Mutation_p.L515V|RPGR_ENST00000318842.7_Missense_Mutation_p.L515V|RPGR_ENST00000309513.3_Missense_Mutation_p.L453V|RPGR_ENST00000339363.3_Missense_Mutation_p.L515V	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	515					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						GATAATTTTAATGACTTTTCA	0.239000													6	30					0	0	0.001984	0	0
ZNF146	7705	broad.mit.edu	37	19	36727471	36727471	+	Silent	SNP	T	T	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:36727471T>G	ENST00000456324.1	+	3	1578	c.129T>G	c.(127-129)ccT>ccG	p.P43P	ZNF146_ENST00000443387.2_Silent_p.P43P|ZNF565_ENST00000355114.5_Intron	NM_001099638.1|NM_001099639.1	NP_001093108.1|NP_001093109.1	Q15072	OZF_HUMAN	zinc finger protein 146	43					regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11	Esophageal squamous(110;0.162)					GAGAGAAACCTTTTGAATGTA	0.418000													130	70					0	0	0.014410	0	0
DHX33	56919	broad.mit.edu	37	17	5365687	5365687	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:5365687C>T	ENST00000225296.3	-	3	830	c.630G>A	c.(628-630)gtG>gtA	p.V210V	DHX33_ENST00000433302.3_Intron	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	210	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GTGCAGCTTTCACCACTCCAA	0.453000													38	19					0	0	0.004878	0	0
FAM47C	442444	broad.mit.edu	37	X	37029100	37029100	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:37029100G>C	ENST00000358047.3	+	1	2669	c.2617G>C	c.(2617-2619)Gac>Cac	p.D873H		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	873										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CAGTCTGTTTGACTTTACCCC	0.458000													8	133					0	0	0.004482	0	0
RLF	6018	broad.mit.edu	37	1	40701823	40701823	+	Silent	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:40701823A>G	ENST00000372771.4	+	8	1476	c.1449A>G	c.(1447-1449)ttA>ttG	p.L483L		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	483					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			ACCAACTTTTAGGACAAGAAG	0.403000													3	128					0	0	0.009096	0	0
ASB13	79754	broad.mit.edu	37	10	5691004	5691004	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:5691004T>C	ENST00000357700.6	-	4	472	c.446A>G	c.(445-447)cAt>cGt	p.H149R	ASB13_ENST00000479033.1_5'UTR	NM_024701.3	NP_078977.2	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box containing 13	149					intracellular signal transduction		protein binding			NS(1)|endometrium(3)|lung(3)|ovary(1)	8				GBM - Glioblastoma multiforme(2;9.59e-09)		GGTCCCAAAATGGCAATCGTG	0.542000													34	118					0	0	0.003271	0	0
HCAR2	338442	broad.mit.edu	37	12	123187019	123187019	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:123187019G>A	ENST00000328880.5	-	1	871	c.812C>T	c.(811-813)tCg>tTg	p.S271L	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	271					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	CAGGTCCACCGAGCGGTACAC	0.542000													5	52					0	0	0.000602	0	0
MAP3K13	9175	broad.mit.edu	37	3	185191526	185191526	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:185191526C>T	ENST00000265026.3	+	11	2741	c.2407C>T	c.(2407-2409)Cga>Tga	p.R803*	MAP3K13_ENST00000424227.1_Nonsense_Mutation_p.R803*|MAP3K13_ENST00000443863.1_Nonsense_Mutation_p.R659*|MAP3K13_ENST00000446828.1_Nonsense_Mutation_p.R596*|MAP3K13_ENST00000535426.1_Nonsense_Mutation_p.R659*	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	803					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGCGCTACCTCGAAAAACAAG	0.507000													11	213					0	0	0.001855	0	0
CELSR1	9620	broad.mit.edu	37	22	46929664	46929664	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:46929664G>C	ENST00000262738.3	-	1	3403	c.3404C>G	c.(3403-3405)tCa>tGa	p.S1135*	CELSR1_ENST00000395964.1_Nonsense_Mutation_p.S1135*|CELSR1_ENST00000497509.1_5'UTR	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1135	Cadherin 9.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAGGCTGTCTGACACGTCGGG	0.617000													6	75					0	0	0.001984	0	0
CRP	1401	broad.mit.edu	37	1	159684367	159684367	+	Translation_Start_Site	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:159684367G>C	ENST00000255030.5	-	0	12				CRP_ENST00000368112.1_De_novo_Start_OutOfFrame|CRP_ENST00000437342.1_De_novo_Start_OutOfFrame|CRP_ENST00000368110.1_De_novo_Start_OutOfFrame|CRP_ENST00000343919.2_De_novo_Start_OutOfFrame|CRP_ENST00000368111.1_De_novo_Start_OutOfFrame	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related						acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AGAAGTCCTAGATCTCTTGCC	0.458000													3	12					0	0	0.004672	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43937144	43937144	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:43937144C>G	ENST00000282406.4	+	12	2092	c.1982C>G	c.(1981-1983)tCt>tGt	p.S661C		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	661	Ser-rich.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCTCTCTCCTCTGTGGCTTCT	0.458000													8	166					0	0	0.004482	0	0
RNF219	79596	broad.mit.edu	37	13	79219061	79219061	+	Silent	SNP	A	A	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:79219061A>G	ENST00000282003.6	-	2	202	c.144T>C	c.(142-144)aaT>aaC	p.N48N		NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	48							zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		ACTGGCTATTATTCTTCAACC	0.368000													20	66					0	0	0.008871	0	0
GDPD2	54857	broad.mit.edu	37	X	69646848	69646848	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:69646848G>A	ENST00000453994.2	+	8	1050	c.689G>A	c.(688-690)cGa>cAa	p.R230Q	GDPD2_ENST00000374382.3_Missense_Mutation_p.R230Q|GDPD2_ENST00000538649.1_Missense_Mutation_p.R151Q|GDPD2_ENST00000536730.1_Missense_Mutation_p.R151Q|GDPD2_ENST00000472623.1_3'UTR	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	230	GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding	p.R230Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					GTGGGACACCGAGGGGCCCCC	0.612000													7	34					0	0	0.001984	0	0
NUDT13	25961	broad.mit.edu	37	10	74879774	74879774	+	Splice_Site	SNP	A	A	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:74879774A>C	ENST00000357321.4	+	3	201		c.e3-1		NUDT13_ENST00000349051.5_Splice_Site|NUDT13_ENST00000488223.1_Splice_Site|NUDT13_ENST00000372997.3_Splice_Site|NUDT13_ENST00000544879.1_Splice_Site|NUDT13_ENST00000537969.1_Splice_Site	NM_001283016.1|NM_015901.4	NP_001269945.1|NP_056985.3	Q86X67	NUD13_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 13								hydrolase activity|metal ion binding			large_intestine(2)|lung(5)	7	Prostate(51;0.0119)					TCCCAAATACAGGTATTTATT	0.408000													5	41					0	0	0.000602	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68265271	68265271	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:68265271G>C	ENST00000347230.4	-	11	1846	c.1708C>G	c.(1708-1710)Ctg>Gtg	p.L570V	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.L570V	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	570					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCCAGGCACAGAGAGTCAGGA	0.478000													5	47					0	0	0.000602	0	0
MYH13	8735	broad.mit.edu	37	17	10209797	10209797	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:10209797C>A	ENST00000418404.3	-	36	5608	c.5445G>T	c.(5443-5445)caG>caT	p.Q1815H	MYH13_ENST00000252172.4_Missense_Mutation_p.Q1815H|RP11-401O9.4_ENST00000609088.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1815					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GTTTCTGGATCTGCTTCTTCC	0.537000													19	184					8.00594e-06	8.47458e-06	0.007413	1	0
CARD9	64170	broad.mit.edu	37	9	139266398	139266398	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:139266398C>T	ENST00000371732.5	-	2	298	c.133G>A	c.(133-135)Gag>Aag	p.E45K	CARD9_ENST00000371734.3_Missense_Mutation_p.E45K|CARD9_ENST00000315908.7_Missense_Mutation_p.E45K	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	45	CARD.				positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		ACCTGCTCCTCATCATCGGGG	0.637000													30	161					0	0	0.006320	0	0
S100A9	6280	broad.mit.edu	37	1	153333180	153333180	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:153333180G>A	ENST00000368738.3	+	3	254	c.211G>A	c.(211-213)Gac>Aac	p.D71N		NM_002965.3	NP_002956.1	P06702	S10A9_HUMAN	S100 calcium binding protein A9	71	EF-hand 2.				cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACAAATGCAGACAAGCAGCT	0.562000													37	53					0	0	0.005524	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144864265	144864265	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:144864265G>C	ENST00000369359.4	-	39	6276	c.6238C>G	c.(6238-6240)Caa>Gaa	p.Q2080E	PDE4DIP_ENST00000369356.4_Missense_Mutation_p.Q1944E|RP4-791M13.4_ENST00000532137.1_RNA|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.Q1838E|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.Q2029E|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.Q1944E			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1944					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCAGCTCTTGAAGGTGGGAT	0.527000			T	PDGFRB	MPD								12	303					0	0	0.001855	0	0
UTP20	27340	broad.mit.edu	37	12	101686964	101686964	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:101686964G>A	ENST00000261637.4	+	11	1366	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	398					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GAGCAGATTTGAAAAACGTTT	0.353000													15	39					0	0	0.002450	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17696923	17696923	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:17696923C>G	ENST00000399080.2	-	1	2783	c.2760G>C	c.(2758-2760)aaG>aaC	p.K920N		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	920										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CAGAGTCATTCTTTCTGTGAA	0.289000													9	35					0	0	0.006214	0	0
FAF2	23197	broad.mit.edu	37	5	175921066	175921066	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:175921066G>T	ENST00000261942.6	+	6	603	c.550G>T	c.(550-552)Gac>Tac	p.D184Y		NM_014613.2	NP_055428.1	Q96CS3	FAF2_HUMAN	Fas associated factor family member 2	184					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			breast(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TGATCACCAGGACTCTGATGA	0.398000													28	62					7.26314e-15	7.88051e-15	0.007291	1	0
BAGE2	85319	broad.mit.edu	37	21	11039216	11039216	+	RNA	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr21:11039216G>C	ENST00000470054.1	-	0	987									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGAGGCCTTGATTCTTCTTT	0.428000													5	239					0	0	0.000602	0	0
BMPR2	659	broad.mit.edu	37	2	203420028	203420028	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:203420028C>T	ENST00000374580.4	+	12	2179	c.1640C>T	c.(1639-1641)tCt>tTt	p.S547F	BMPR2_ENST00000374574.2_Intron	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	547	Poly-Ser.				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						CCAGATTATTCTTCCTCCTCA	0.383000													15	24					0	0	0.002450	0	0
RARS2	57038	broad.mit.edu	37	6	88299660	88299660	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:88299660G>A	ENST00000369536.5	-	1	61	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C		NM_020320.3	NP_064716.2	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	6					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding	p.R6C(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		ATAGCGCGGCGAAAGCCGCAC	0.672000											OREG0031911	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	15	33					0	0	0.004007	0	0
DNAJC17	55192	broad.mit.edu	37	15	41071455	41071455	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:41071455C>G	ENST00000220496.4	-	4	291	c.261G>C	c.(259-261)caG>caC	p.Q87H		NM_018163.2	NP_060633.1	Q9NVM6	DJC17_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 17	87					protein folding		heat shock protein binding|nucleotide binding|RNA binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|skin(1)	6		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CATCAAGTTTCTGGGTCCTCT	0.507000													14	89					0	0	0.003163	0	0
TSGA10	80705	broad.mit.edu	37	2	99721848	99721848	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:99721848C>G	ENST00000393483.3	-	9	1277	c.433G>C	c.(433-435)Gag>Cag	p.E145Q	TSGA10_ENST00000542655.1_Missense_Mutation_p.E145Q|TSGA10_ENST00000355053.4_Missense_Mutation_p.E145Q|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000410001.1_Missense_Mutation_p.E145Q|TSGA10_ENST00000539964.1_Missense_Mutation_p.E145Q	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	145					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TCCAGCTCCTCTATCCTTTGT	0.338000													3	46					0	0	0.004672	0	0
ZNF91	7644	broad.mit.edu	37	19	23545301	23545301	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:23545301C>G	ENST00000300619.7	-	4	685	c.480G>C	c.(478-480)ttG>ttC	p.L160F	ZNF91_ENST00000397082.2_Missense_Mutation_p.L128F|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	160						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGAAGACTTTCAAATATTTCC	0.328000													15	51					0	0	0.003163	0	0
JADE3	9767	broad.mit.edu	37	X	46884244	46884244	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:46884244G>C	ENST00000218343.4	+	5	701	c.403G>C	c.(403-405)Gtt>Ctt	p.V135L	PHF16_ENST00000397189.1_Missense_Mutation_p.V135L	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		135					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						GGCAGCATCTGTTTGCCGCTA	0.468000													18	52					0	0	0.007413	0	0
FAM160A2	84067	broad.mit.edu	37	11	6232852	6232852	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:6232852G>C	ENST00000265978.4	-	12	3203	c.2845C>G	c.(2845-2847)Ctc>Gtc	p.L949V	FAM160A2_ENST00000529360.1_5'UTR|FAM160A2_ENST00000449352.2_Missense_Mutation_p.L935V	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	935					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AACTCCTTGAGAAATTCAGGG	0.557000													21	89					0	0	0.014323	0	0
CENPF	1063	broad.mit.edu	37	1	214814564	214814564	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:214814564C>T	ENST00000366955.3	+	12	3051	c.2883C>T	c.(2881-2883)atC>atT	p.I961I		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	961					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGAGTTCCATCATTTCTCTAA	0.353000													14	63					0	0	0.003163	0	0
INHA	3623	broad.mit.edu	37	2	220437228	220437228	+	Silent	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:220437228C>T	ENST00000243786.2	+	1	312	c.132C>T	c.(130-132)ccC>ccT	p.P44P	INHA_ENST00000489456.1_Intron	NM_002191.3	NP_002182.1	P05111	INHA_HUMAN	inhibin, alpha	44					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGGGGCCCCCCGCGGTGACCA	0.687000											OREG0003991	type=REGULATORY REGION|Gene=BC045558|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	10					0	0	0.001984	0	0
ATP5J2-PTCD1	100526740	broad.mit.edu	37	7	99057790	99057790	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:99057790C>G	ENST00000413834.1	-	2	62	c.40G>C	c.(40-42)Gag>Cag	p.E14Q	ATP5J2-PTCD1_ENST00000437572.1_Intron|ATP5J2_ENST00000544611.1_Missense_Mutation_p.E14Q|ATP5J2_ENST00000449683.1_Missense_Mutation_p.E24Q|ATP5J2_ENST00000292475.3_Missense_Mutation_p.E20Q|ATP5J2_ENST00000359832.4_Missense_Mutation_p.E20Q|PTCD1_ENST00000555673.1_Missense_Mutation_p.E14Q|ATP5J2_ENST00000488775.1_Missense_Mutation_p.E14Q|ATP5J2_ENST00000466753.1_Intron|ATP5J2_ENST00000394186.3_Missense_Mutation_p.E14Q			B4DJ38	B4DJ38_HUMAN		14																	AGTTTGACCTCCAGAAGTTTC	0.483000													30	157					0	0	0.009535	0	0
C17orf53	78995	broad.mit.edu	37	17	42232692	42232692	+	Silent	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:42232692C>A	ENST00000319977.4	+	8	1923	c.1686C>A	c.(1684-1686)ctC>ctA	p.L562L	C17orf53_ENST00000585683.1_Silent_p.L561L|C17orf53_ENST00000245382.6_Silent_p.L486L	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	562										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		ATCACTACCTCAACGTGACAC	0.527000													4	103					2.56e-06	2.72314e-06	0.009096	1	0
CORO1A	11151	broad.mit.edu	37	16	30199708	30199708	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:30199708C>A	ENST00000219150.5	+	10	1397	c.1092C>A	c.(1090-1092)taC>taA	p.Y364*	CORO1A_ENST00000570045.1_Nonsense_Mutation_p.Y364*|CORO1A_ENST00000565497.1_Intron	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	364					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						AGGACCTGTACCCACCCACCG	0.647000													30	94					6.05902e-23	6.62371e-23	0.003755	1	0
PPP3R2	5535	broad.mit.edu	37	9	104357001	104357001	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:104357001C>G	ENST00000374806.1	-	1	282	c.212G>C	c.(211-213)gGa>gCa	p.G71A	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	68	EF-hand 2.						calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	GTCCACTTCTCCATCACCGTC	0.577000													15	86					0	0	0.002450	0	0
PCDH15	65217	broad.mit.edu	37	10	55581860	55581860	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:55581860G>C	ENST00000361849.3	-	34	6026	c.5632C>G	c.(5632-5634)Cag>Gag	p.Q1878E	PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.Q1807E|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.Q1873E|PCDH15_ENST00000373957.3_Missense_Mutation_p.Q730E|PCDH15_ENST00000320301.6_Missense_Mutation_p.Q1876E|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.Q1853E|PCDH15_ENST00000395432.2_Missense_Mutation_p.Q1836E	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1876					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GGTTCTCTCTGAGGGTCTGTT	0.388000										HNSCC(58;0.16)			58	67					0	0	0.014410	0	0
OR1J2	26740	broad.mit.edu	37	9	125273495	125273495	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:125273495G>C	ENST00000335302.5	+	1	415	c.415G>C	c.(415-417)Gag>Cag	p.E139Q		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						CATGAGGGAAGAGCTCTGTGT	0.478000													8	51					0	0	0.003080	0	0
MED12	9968	broad.mit.edu	37	X	70338701	70338701	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:70338701G>A	ENST00000333646.6	+	1	296	c.97G>A	c.(97-99)Gag>Aag	p.E33K	MED12_ENST00000374102.1_Missense_Mutation_p.E33K|MED12_ENST00000374080.3_Missense_Mutation_p.E33K	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	33					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CAAACAGAAGGAGGTGCGTTC	0.677000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						5	9					0	0	0.001168	0	0
KALRN	8997	broad.mit.edu	37	3	124066028	124066028	+	Silent	SNP	C	C	A			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:124066028C>A	ENST00000360013.3	+	10	1807	c.1680C>A	c.(1678-1680)ctC>ctA	p.L560L	KALRN_ENST00000240874.3_Silent_p.L560L|KALRN_ENST00000460856.1_Silent_p.L560L	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	560					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGGCCTTTCTCAGCAAACACA	0.493000													36	141					6.2361e-21	6.80017e-21	0.007835	1	0
ASXL3	80816	broad.mit.edu	37	18	31323516	31323516	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:31323516C>T	ENST00000269197.5	+	12	3704	c.3704C>T	c.(3703-3705)tCt>tTt	p.S1235F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1235	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AATAAAAATTCTGTCCCTGTA	0.373000													8	128					0	0	0.003080	0	0
SPAG17	200162	broad.mit.edu	37	1	118640369	118640379	+	Frame_Shift_Del	DEL	AGATTTGTTTC	AGATTTGTTTC	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:118640369_118640379delAGATTTGTTTC	ENST00000336338.5	-	7	990_1000	c.925_935delGAAACAAATCT	c.(925-936)gaaacaaatctcfs	p.ETNL309fs		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	309						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AACATCAAAGAGATTTGTTTCAGGTTTCTCA	0.374													17	37	---	---	---	---					
TSSC1	7260	broad.mit.edu	37	2	3197914	3197915	+	In_Frame_Ins	INS	-	-	CAT			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:3197914_3197915insCAT	ENST00000398659.4	-	8	897_898	c.757_758insATG	c.(757-759)gcc>gATGcc	p.252_253insD	TSSC1_ENST00000478754.1_De_novo_Start_InFrame|TSSC1_ENST00000382125.4_In_Frame_Ins_p.225_226insD			Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	225							protein binding			breast(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	18	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		CTGTCCGTGGGCATTCTCTATG	0.515													35	96	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:98427639delT	ENST00000186436.5	-	18	2148	c.1920delA	c.(1918-1920)aaafs	p.K640fs		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	640						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TCCCCTCTAATTTTTTTGCAG	0.393													8	261	---	---	---	---					
VGLL4	9686	broad.mit.edu	37	3	11744444	11744444	+	Splice_Site	DEL	C	C	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:11744444delC	ENST00000273038.3	-	2	430		c.e2+1		VGLL4_ENST00000404339.1_Splice_Site	NM_001284391.1|NM_014667.2	NP_001271320.1|NP_055482.2	Q14135	VGLL4_HUMAN	vestigial like 4 (Drosophila)						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		TCCTCACTTACGTTTTTCGTC	0.418													13	16	---	---	---	---					
HOXA1	3198	broad.mit.edu	37	7	27135004	27135010	+	Frame_Shift_Del	DEL	ATACGTA	ATACGTA	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:27135004_27135010delATACGTA	ENST00000343060.4	-	1	583_589	c.522_528delTACGTAT	c.(520-528)gctacgtatfs	p.ATY174fs	HOXA1_ENST00000355633.5_Intron	NM_005522.4	NP_005513	P49639	HXA1_HUMAN	homeobox A1	174						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AGGAGTTATTATACGTAGCCAGGGCCA	0.580													51	129	---	---	---	---					
ZCCHC8	55596	broad.mit.edu	37	12	122958340	122958340	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:122958340delC	ENST00000543897.1	-	12	3469	c.1114delG	c.(1114-1116)gaafs	p.E372fs	ZCCHC8_ENST00000336229.4_Frame_Shift_Del_p.E610fs|ZCCHC8_ENST00000536306.1_Frame_Shift_Del_p.E372fs|ZCCHC8_ENST00000538116.1_Frame_Shift_Del_p.E221fs			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	610						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TCTGCTTTTTCCTTCTGACAA	0.493													7	262	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													4	6	---	---	---	---					
ARHGAP27	201176	broad.mit.edu	37	17	43473589	43473589	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:43473589delG	ENST00000532038.1	-	13	1704	c.1569delC	c.(1567-1569)cgcfs	p.R523fs	ARHGAP27_ENST00000442348.1_Frame_Shift_Del_p.R718fs|ARHGAP27_ENST00000428638.1_Frame_Shift_Del_p.R745fs|ARHGAP27_ENST00000376922.2_Frame_Shift_Del_p.R404fs|ARHGAP27_ENST00000455881.1_Frame_Shift_Del_p.R404fs|ARHGAP27_ENST00000532891.2_Frame_Shift_Del_p.R723fs|ARHGAP27_ENST00000528384.1_Frame_Shift_Del_p.R377fs			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	745	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CCACCTTATAGCGTAGCTTCT	0.647													32	57	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													7	152	---	---	---	---