Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SCNN1D	6339	broad.mit.edu	37	1	1226700	1226700	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:1226700C>T	uc001adu.1	+	17	2251	c.1627C>T	c.(1627-1629)CTC>TTC	p.L543F	SCNN1D_uc001adt.1_Missense_Mutation_p.L707F|SCNN1D_uc001adw.2_Missense_Mutation_p.L609F|SCNN1D_uc001adx.2_Missense_Mutation_p.L332F|SCNN1D_uc001adv.2_Missense_Mutation_p.L543F	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CGTCCTCTCCCTCCTGGAGCT	0.721		NaN											0	0	0	0.014758	0	5	21									
ARID1A	8289	broad.mit.edu	37	1	27106539	27106539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:27106539G>A	uc001bmv.1	+	20	6523	c.6150G>A	c.(6148-6150)TGG>TGA	p.W2050*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.W1833*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.W896*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.W378*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.W292*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2050					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGTGGTGGTGGGACTGCTTGG	0.552		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.139131	0	54	49									
SNIP1	79753	broad.mit.edu	37	1	38018319	38018319	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:38018319G>A	uc001cbi.2	-	2	327	c.254C>T	c.(253-255)TCA>TTA	p.S85L	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	85	Arg-rich.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				TCTTCTCCCTGAGGCCTTGTT	0.458		NaN											0	0	0	0.139131	0	82	162									
FPGT	8790	broad.mit.edu	37	1	74670509	74670509	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:74670509G>A	uc001dgb.1	+	4	815	c.778G>A	c.(778-780)GAT>AAT	p.D260N	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	260					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TGACATTGCCGATCTTAAATT	0.358		NaN											0	0	0	0.116897	0	29	60									
F5	2153	broad.mit.edu	37	1	169487767	169487767	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:169487767C>G	uc001ggg.1	-	23	6373	c.6228G>C	c.(6226-6228)AAG>AAC	p.K2076N		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2076	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGTTTTCTATCTTTCCATTTT	0.448		NaN											0	0	0	0.021553	0	5	40									
IPO9	55705	broad.mit.edu	37	1	201828120	201828120	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:201828120C>T	uc001gwz.2	+	13	1516	c.1466C>T	c.(1465-1467)TCA>TTA	p.S489L		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	489					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CTCAACCTCTCAGGTATGTTT	0.318		NaN											0	0	0	0.105934	0	14	39									
TP53BP2	7159	broad.mit.edu	37	1	223984139	223984139	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:223984139C>T	uc010pvb.1	-	13	2394	c.2102G>A	c.(2101-2103)CGG>CAG	p.R701Q	TP53BP2_uc001hod.2_Missense_Mutation_p.R572Q|TP53BP2_uc010puz.1_5'UTR|TP53BP2_uc010pva.1_Missense_Mutation_p.R340Q	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	695					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCTGAGTGGCCGAGGAATTCT	0.448		NaN											0	0	0	0.139131	0	91	102									
CYP26C1	340665	broad.mit.edu	37	10	94821038	94821038	+	Silent	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:94821038G>A	uc010qns.1	+	1	18	c.18G>A	c.(16-18)CTG>CTA	p.L6L	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	6					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				CTTGGGGGCTGAGCTGCCTGT	0.711		NaN											0	0	0	0.021553	0	6	4									
C10orf12	26148	broad.mit.edu	37	10	98743230	98743230	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:98743230G>A	uc001kmv.2	+	1	2190	c.2083G>A	c.(2083-2085)GAG>AAG	p.E695K		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	695										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GAAAGATGATGAGAGTGATGC	0.517		NaN											0	0	0	0.105934	0	14	55									
ABCC2	1244	broad.mit.edu	37	10	101571351	101571351	+	Silent	SNP	A	A	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:101571351A>T	uc001kqf.2	+	15	2098	c.1959A>T	c.(1957-1959)ACA>ACT	p.T653T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	653	Cytoplasmic (By similarity).|ABC transporter 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CGGAAGCCACAGTCCGAGAGT	0.453		NaN											0	0	0	0.086207	0	36	37									
ANO5	203859	broad.mit.edu	37	11	22249087	22249087	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:22249087C>T	uc001mqi.2	+	7	920	c.603C>T	c.(601-603)ATC>ATT	p.I201I	ANO5_uc001mqj.2_Silent_p.I200I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	201	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TCTTCCTCATCGAAGATCAGG	0.453		NaN											0	0	0	0.076483	0	25	61									
FIBIN	387758	broad.mit.edu	37	11	27016101	27016101	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:27016101A>C	uc001mrd.2	+	1	474	c.28A>C	c.(28-30)AGT>CGT	p.S10R		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	10						extracellular region|Golgi apparatus					0						CTTCTGCATGAGTTTCTTCTG	0.527		NaN											0	0	0	0.09836	0	36	25									
OR5M8	219484	broad.mit.edu	37	11	56258428	56258428	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:56258428C>A	uc001nix.1	-	1	419	c.419G>T	c.(418-420)TGC>TTC	p.C140F		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GAGGAAGGAGCACACACTCTT	0.522		NaN											1	0	1.17739e-12	0.108266	1.29397e-12	29	44									
CTSW	1521	broad.mit.edu	37	11	65649734	65649734	+	Silent	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:65649734G>A	uc001ogc.1	+	4	417	c.375G>A	c.(373-375)GAG>GAA	p.E125E	CTSW_uc001ogb.1_Silent_p.E125E	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	125					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		AAGAGCCAGAGGAGTCAGTAC	0.582		NaN											0	0	0	0.069288	0	21	120									
FAT3	120114	broad.mit.edu	37	11	92623737	92623737	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:92623737G>A	uc001pdj.3	+	25	13149	c.13132G>A	c.(13132-13134)GAT>AAT	p.D4378N	FAT3_uc001pdi.3_Missense_Mutation_p.D850N	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4410	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAGAACCAGGATGGAGGGTC	0.547		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.069234	0	11	24									
BUD13	84811	broad.mit.edu	37	11	116619253	116619253	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:116619253G>A	uc001ppn.2	-	10	1839	c.1805C>T	c.(1804-1806)GCC>GTC	p.A602V	BUD13_uc001ppo.2_Missense_Mutation_p.A468V	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	602										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTTCTTGCTGGCAAGCCTGGC	0.478		NaN											0	0	0	0.0918	0	24	34									
APOC3	345	broad.mit.edu	37	11	116701559	116701559	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:116701559C>T	uc001ppt.1	+	3	172	c.126C>T	c.(124-126)ACC>ACT	p.T42T		NM_000040	NP_000031	P02656	APOC3_HUMAN	apolipoprotein C-III precursor	42					Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol import|negative regulation of fatty acid biosynthetic process|negative regulation of high-density lipoprotein particle clearance|negative regulation of lipoprotein lipase activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor-mediated endocytosis|negative regulation of triglyceride catabolic process|negative regulation of very-low-density lipoprotein particle clearance|negative regulation of very-low-density lipoprotein particle remodeling|phospholipid efflux|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle assembly	chylomicron|intermediate-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	high-density lipoprotein particle receptor binding|lipase inhibitor activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CCACCAAGACCGCCAAGGATG	0.647		NaN											0	0	0	0.021553	0	6	17									
KIF21A	55605	broad.mit.edu	37	12	39760203	39760203	+	Silent	SNP	A	A	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:39760203A>G	uc001rly.2	-	6	998	c.852T>C	c.(850-852)ACT>ACC	p.T284T	KIF21A_uc001rlx.2_Silent_p.T284T|KIF21A_uc001rlz.2_Silent_p.T284T|KIF21A_uc010skl.1_Silent_p.T284T|KIF21A_uc001rma.1_Silent_p.T292T	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	284	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CTGTAGCTCCAGTACGCTTCA	0.393		NaN											0	0	0	0.099896	0	25	53									
GDF11	10220	broad.mit.edu	37	12	56143622	56143622	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:56143622G>A	uc001shq.2	+	3	1217	c.1180G>A	c.(1180-1182)GGC>AGC	p.G394S	GDF11_uc010spv.1_Missense_Mutation_p.G394S	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	394					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						GATTATCTACGGCAAGATCCC	0.572		NaN											0	0	0	0.183431	0	34	133									
PTPRB	5787	broad.mit.edu	37	12	70953310	70953310	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:70953310G>T	uc001swb.3	-	16	3903	c.3873C>A	c.(3871-3873)AAC>AAA	p.N1291K	PTPRB_uc010sto.1_Missense_Mutation_p.N1201K|PTPRB_uc010stp.1_Missense_Mutation_p.N1201K|PTPRB_uc001swc.3_Missense_Mutation_p.N1509K|PTPRB_uc001swa.3_Missense_Mutation_p.N1421K|PTPRB_uc001swd.3_Missense_Mutation_p.N1508K|PTPRB_uc009zrr.1_Missense_Mutation_p.N1388K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1291	Fibronectin type-III 15.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTCAAAGTCGTTGTAGTCTG	0.493		NaN											1	0	5.00936e-31	0.139131	5.61655e-31	66	196									
C12orf51	283450	broad.mit.edu	37	12	112670808	112670808	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:112670808C>G	uc009zwc.2	-	31	4749	c.4731G>C	c.(4729-4731)AAG>AAC	p.K1577N		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATGAGGTTACCTTGGTCATGT	0.403		NaN											0	0	0	0.02938	0	7	6									
SLC8A3	6547	broad.mit.edu	37	14	70515701	70515701	+	Silent	SNP	G	G	A	rs149109491	byFrequency	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr14:70515701G>A	uc001xly.2	-	7	2944	c.2190C>T	c.(2188-2190)TAC>TAT	p.Y730Y	SLC8A3_uc001xlu.2_Silent_p.Y87Y|SLC8A3_uc001xlv.2_Silent_p.Y101Y|SLC8A3_uc001xlw.2_Silent_p.Y727Y|SLC8A3_uc001xlx.2_Silent_p.Y728Y|SLC8A3_uc001xlz.2_Silent_p.Y724Y|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Silent_p.Y87Y	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	730	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGTGCATGACGTAGTCAAAGC	0.572		NaN											0	0	0	0.108266	0	28	43									
DICER1	23405	broad.mit.edu	37	14	95579563	95579563	+	Splice_Site	SNP	T	T	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr14:95579563T>A	uc001ydw.2	-	13	2090	c.1908_splice	c.e13-1	p.R636_splice	DICER1_uc001ydv.2_Splice_Site_p.R626_splice|DICER1_uc001ydx.2_Splice_Site_p.R636_splice	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1						negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GCACAGTATCTGTGAAGAAAA	0.378		NaN	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.069288	0	23	55									
SEMA6D	80031	broad.mit.edu	37	15	48052549	48052549	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr15:48052549C>T	uc010bek.2	+	3	518	c.158C>T	c.(157-159)TCG>TTG	p.S53L	SEMA6D_uc001zvw.2_Missense_Mutation_p.S53L|SEMA6D_uc001zvx.1_Missense_Mutation_p.S53L|SEMA6D_uc001zvy.2_Missense_Mutation_p.S53L|SEMA6D_uc001zvz.2_Missense_Mutation_p.S53L|SEMA6D_uc001zwa.2_Missense_Mutation_p.S53L|SEMA6D_uc001zwb.2_Missense_Mutation_p.S53L|SEMA6D_uc001zwc.2_Missense_Mutation_p.S53L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	53	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GGCAATGAATCGCAGCACAGG	0.408		NaN											0	0	0	0.047766	0	9	50									
CA12	771	broad.mit.edu	37	15	63637770	63637770	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr15:63637770C>T	uc002amc.2	-	4	491	c.335G>A	c.(334-336)CGC>CAC	p.R112H	CA12_uc002amd.2_Missense_Mutation_p.R112H|CA12_uc002ame.2_Missense_Mutation_p.R52H	NM_001218	NP_001209	O43570	CAH12_HUMAN	carbonic anhydrase XII isoform 1 precursor	112	Extracellular (Potential).				one-carbon metabolic process	integral to membrane	carbonate dehydratase activity|zinc ion binding			ovary(1)	1					Acetazolamide(DB00819)	GGCACTGTAGCGAGACTGGAG	0.657		NaN											0	0	0	0.115264	0	3	18									
BTBD12	84464	broad.mit.edu	37	16	3633236	3633236	+	Missense_Mutation	SNP	T	T	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr16:3633236T>C	uc002cvp.2	-	14	5642	c.5015A>G	c.(5014-5016)CAT>CGT	p.H1672R		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1672	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GATGCTTTCATGATGCTTCCT	0.627		NaN						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.139131	0	54	57									
SLC6A2	6530	broad.mit.edu	37	16	55719143	55719143	+	Missense_Mutation	SNP	G	G	A	rs1805066	byFrequency	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr16:55719143G>A	uc002eif.2	+	5	844	c.733G>A	c.(733-735)GTC>ATC	p.V245I	SLC6A2_uc010ccd.2_Missense_Mutation_p.V245I|SLC6A2_uc002eig.2_Missense_Mutation_p.V245I|SLC6A2_uc002eih.2_Missense_Mutation_p.V245I|SLC6A2_uc002eii.2_Missense_Mutation_p.V140I|SLC6A2_uc002eij.2_Missense_Mutation_p.V4I	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	245	Helical; Name=4; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GATGGTCGTCGTCATCGTCTT	0.527		NaN											0	0	0	0.055883	0	19	64									
CHD3	1107	broad.mit.edu	37	17	7797579	7797579	+	Missense_Mutation	SNP	G	G	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr17:7797579G>T	uc002gje.2	+	7	1221	c.1071G>T	c.(1069-1071)AAG>AAT	p.K357N	CHD3_uc002gjd.2_Missense_Mutation_p.K416N|CHD3_uc002gjf.2_Missense_Mutation_p.K357N|CHD3_uc002gjg.1_Missense_Mutation_p.K185N	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	357	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGAAGAAGAAGAAGGGTAAGG	0.488		NaN											1	0	1.58986e-06	0.069234	1.66486e-06	11	45									
PYCR1	5831	broad.mit.edu	37	17	79892987	79892987	+	Missense_Mutation	SNP	G	G	A	rs121918376		TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr17:79892987G>A	uc002kcr.1	-	4	633	c.355C>T	c.(355-357)CGC>TGC	p.R119C	PYCR1_uc002kcq.1_Missense_Mutation_p.R119C|PYCR1_uc002kcp.2_Missense_Mutation_p.R119C|PYCR1_uc002kcs.1_Missense_Mutation_p.R119C|PYCR1_uc010wvd.1_Missense_Mutation_p.R146C|PYCR1_uc002kct.1_Missense_Mutation_p.R119C|PYCR1_uc002kcu.1_Missense_Mutation_p.R119C|PYCR1_uc010wve.1_Missense_Mutation_p.R71C	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	119			R -> H (in ARCL2B).|R -> G (in ARCL2B).		cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	GTCATGCAGCGGATGACCCTG	0.647		NaN											0	0	0	0.043863	0	18	24									
MUC16	94025	broad.mit.edu	37	19	9063763	9063763	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:9063763G>A	uc002mkp.2	-	3	23887	c.23683C>T	c.(23683-23685)CCT>TCT	p.P7895S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7897	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCATGACAGGGGATGTAGAG	0.498		NaN											0	0	0	0.092188	0	40	70									
DOCK6	57572	broad.mit.edu	37	19	11325227	11325227	+	Splice_Site	SNP	A	A	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:11325227A>G	uc002mqs.3	-	33	4244	c.4203_splice	c.e33+1	p.Q1401_splice	DOCK6_uc010xlq.1_Splice_Site_p.Q740_splice	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						ATCAAGCCCTACCTGCACGAT	0.557		NaN											0	0	0	0.076483	0	24	27									
ILVBL	10994	broad.mit.edu	37	19	15226826	15226826	+	Missense_Mutation	SNP	G	G	A	rs141415835	by1000genomes	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:15226826G>A	uc002nam.2	-	13	1649	c.1528C>T	c.(1528-1530)CGG>TGG	p.R510W	ILVBL_uc010xof.1_Missense_Mutation_p.R151W|ILVBL_uc010dzw.2_Missense_Mutation_p.R403W	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	510	Thiamine pyrophosphate binding (By similarity).					integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						GCATCTGGCCGGCACAGCTTG	0.597		NaN											0	0	0	0.150653	0	4	44									
CADM4	199731	broad.mit.edu	37	19	44127538	44127538	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:44127538C>T	uc002oxc.1	-	9	1160	c.1111G>A	c.(1111-1113)GAA>AAA	p.E371K		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	371	Cytoplasmic (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				AGGAAGGCTTCTCTTGCTTCT	0.592		NaN											0	0	0	0.131918	0	42	128									
SYMPK	8189	broad.mit.edu	37	19	46341740	46341740	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:46341740C>T	uc002pdn.2	-	10	1466	c.1221G>A	c.(1219-1221)ACG>ACA	p.T407T	SYMPK_uc002pdo.1_Silent_p.T407T|SYMPK_uc002pdp.1_Silent_p.T407T|SYMPK_uc002pdq.1_Silent_p.T407T	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	407					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CATTATCAGGCGTCAGCAGAG	0.602		NaN											0	0	0	0.047766	0	9	22									
PRKD2	25865	broad.mit.edu	37	19	47197163	47197163	+	Silent	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:47197163G>A	uc002pfh.2	-	11	1887	c.1545C>T	c.(1543-1545)GAC>GAT	p.D515D	PRKD2_uc010ekt.2_5'Flank|PRKD2_uc002pfe.2_Silent_p.D35D|PRKD2_uc002pff.2_Silent_p.D35D|PRKD2_uc002pfg.2_Silent_p.D358D|PRKD2_uc002pfi.2_Silent_p.D515D|PRKD2_uc002pfj.2_Silent_p.D515D|PRKD2_uc010xye.1_Silent_p.D515D|PRKD2_uc002pfk.2_Silent_p.D358D	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	515					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CGCTGGGTGCGTCCTGAAGGA	0.687		NaN											0	0	0	0.049695	0	19	57									
KLK12	43849	broad.mit.edu	37	19	51535178	51535178	+	Silent	SNP	G	G	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:51535178G>T	uc002pvg.1	-	3	531	c.411C>A	c.(409-411)GGC>GGA	p.G137G	KLK12_uc010ycp.1_RNA|KLK12_uc010ycq.1_Intron|KLK12_uc010ycr.1_Intron|KLK12_uc010ycs.1_Intron|KLK12_uc002pvh.1_Silent_p.G137G|KLK12_uc002pvi.1_Silent_p.G137G|KLK12_uc002pvj.1_Intron	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	137	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		GGCACTCGGTGCCAGCGGTTG	0.677		NaN											1	0	5.60225e-13	0.144211	6.2185e-13	32	87									
TPO	7173	broad.mit.edu	37	2	1544451	1544451	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:1544451G>A	uc002qww.2	+	16	2795	c.2704G>A	c.(2704-2706)GTA>ATA	p.V902I	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.V845I|TPO_uc002qwr.2_Missense_Mutation_p.V902I|TPO_uc002qwx.2_Missense_Mutation_p.V845I|TPO_uc010yio.1_Missense_Mutation_p.V729I|TPO_uc010yip.1_Missense_Mutation_p.V858I|TPO_uc002qwy.1_Missense_Mutation_p.V198I|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	902	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCACCAGGCCGTAGGGACCTC	0.637		NaN											0	0	0	0.108266	0	27	73									
SNRPG	6637	broad.mit.edu	37	2	70515288	70515288	+	Nonsense_Mutation	SNP	A	A	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:70515288A>T	uc002sgp.2	-	3	180	c.92T>A	c.(91-93)TTG>TAG	p.L31*	SNRPG_uc002sgo.2_RNA	NM_003096	NP_003087	P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G	31					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0						AAATCCCCGCAATATTCCTTG	0.358		NaN											0	0	0	0.021553	0	6	100									
SNRPG	6637	broad.mit.edu	37	2	70515306	70515306	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:70515306C>A	uc002sgp.2	-	3	162	c.74G>T	c.(73-75)AGA>ATA	p.R25I	SNRPG_uc002sgo.2_RNA	NM_003096	NP_003087	P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G	25					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0						TTGGACATGTCTGCCACCATT	0.363		NaN											1	0	0.000602214	0.014758	0.000613264	5	83									
ADD2	119	broad.mit.edu	37	2	70890768	70890768	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:70890768G>A	uc002sgz.2	-	16	2435	c.1970C>T	c.(1969-1971)ACG>ATG	p.T657M	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.T351M|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	657					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TTCCTCTGCCGTCTGCTCCTC	0.572		NaN											0	0	0	0.146539	0	16	151									
FER1L5	90342	broad.mit.edu	37	2	97370381	97370381	+	Silent	SNP	A	A	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:97370381A>G	uc010fia.2	+	52	6234	c.6234A>G	c.(6232-6234)ACA>ACG	p.T2078T	FER1L5_uc002sws.3_Silent_p.T787T|FER1L5_uc002swt.3_Silent_p.T787T|FER1L5_uc010yus.1_Silent_p.T786T	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	2078						integral to membrane				ovary(1)	1						CAGGACCCACAAATCACCTGA	0.527		NaN											0	0	0	0.09836	0	41	57									
POU3F3	5455	broad.mit.edu	37	2	105473459	105473459	+	Silent	SNP	G	G	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:105473459G>C	uc010ywg.1	+	1	1491	c.1491G>C	c.(1489-1491)ACG>ACC	p.T497T		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	497					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						GGCTGCAGACGAGCGTTCAGT	0.473		NaN											0	0	0	0.150653	0	4	16									
NCKAP5	344148	broad.mit.edu	37	2	133539920	133539920	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:133539920T>G	uc002ttp.2	-	14	4838	c.4464A>C	c.(4462-4464)CAA>CAC	p.Q1488H	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1488							protein binding				0						TTGTTTGCACTTGGCCCTTTT	0.507		NaN											0	0	0	0.080935	0	11	108									
ZRANB3	84083	broad.mit.edu	37	2	136107733	136107733	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:136107733C>T	uc002tum.2	-	5	529	c.412G>A	c.(412-414)GAT>AAT	p.D138N	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.D138N|ZRANB3_uc002tun.1_Missense_Mutation_p.D78N	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	138	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GTCTTTGCATCTGCGGTTAAG	0.373		NaN											0	0	0	0.02938	0	5	29									
LRP1B	53353	broad.mit.edu	37	2	141079602	141079602	+	Silent	SNP	A	A	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:141079602A>T	uc002tvj.1	-	82	13542	c.12570T>A	c.(12568-12570)TCT>TCA	p.S4190S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4190	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGTGGCCCCAGAAGGATTTA	0.368		NaN								TSP Lung(27;0.18)			0	0	0	0.139131	0	48	36									
COL4A3	1285	broad.mit.edu	37	2	228104885	228104885	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:228104885C>T	uc002vom.1	+	3	333	c.171C>T	c.(169-171)CCC>CCT	p.P57P	COL4A3_uc002von.1_Silent_p.P57P|COL4A3_uc002voo.1_Silent_p.P57P|COL4A3_uc002vop.1_Silent_p.P57P|uc002voq.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	57	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CTGGACCCCCCGGTTCTCCTG	0.517		NaN											0	0	0	0.11911	0	14	2									
CHGB	1114	broad.mit.edu	37	20	5904368	5904368	+	Silent	SNP	C	C	T	rs138422072		TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr20:5904368C>T	uc002wmg.2	+	4	1884	c.1578C>T	c.(1576-1578)TAC>TAT	p.Y526Y	CHGB_uc010zqz.1_Silent_p.Y209Y	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	526						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ACCCATACTACGACCCTCTCC	0.438		NaN											0	0	0	0.021553	0	6	96									
C20orf12	55184	broad.mit.edu	37	20	18371024	18371024	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr20:18371024T>G	uc010zsa.1	-	18	2155	c.1946A>C	c.(1945-1947)GAG>GCG	p.E649A	C20orf12_uc010zrz.1_Missense_Mutation_p.E168A|C20orf12_uc002wqp.3_Missense_Mutation_p.E340A|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.E516A|C20orf12_uc002wqq.3_Missense_Mutation_p.E630A	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	457	ANK 1.					intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				AACACTTACCTCATCCAGCAG	0.483		NaN											0	0	0	0.116897	0	26	91									
TOP1	7150	broad.mit.edu	37	20	39728847	39728847	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr20:39728847G>A	uc002xjl.2	+	12	1373	c.1127G>A	c.(1126-1128)CGA>CAA	p.R376Q	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	376					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	CTGAAGAGACGAATCATGCCC	0.507		NaN	T	NUP98	AML*								0	0	0	0.0918	0	24	27									
IGSF5	150084	broad.mit.edu	37	21	41142905	41142905	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr21:41142905G>A	uc002yyo.2	+	4	584	c.481G>A	c.(481-483)GTT>ATT	p.V161I		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	161	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				ACCTTGTGAAGTTACTTGTCT	0.468		NaN											0	0	0	0.074837	0	34	46									
FAM118A	55007	broad.mit.edu	37	22	45719182	45719182	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr22:45719182C>T	uc003bfz.3	+	4	790	c.174C>T	c.(172-174)GCC>GCT	p.A58A	FAM118A_uc003bga.3_Silent_p.A58A	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	58						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GCATCGAGGCCGTCATCGAGG	0.642		NaN											0	0	0	0.014758	0	5	83									
PLXNB2	23654	broad.mit.edu	37	22	50721182	50721182	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr22:50721182T>G	uc003bkv.3	-	18	3051	c.2945A>C	c.(2944-2946)AAC>ACC	p.N982T	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	982	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGTACGGGGTTTTCGCGGTA	0.677		NaN											0	0	0	0.11911	0	7	16									
GTPBP8	29083	broad.mit.edu	37	3	112715770	112715770	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr3:112715770G>C	uc003dzn.2	+	4	645	c.598G>C	c.(598-600)GTT>CTT	p.V200L	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Missense_Mutation_p.V167L	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	200	G.				barrier septum formation		GTP binding				0						AGTGGATAGCGTTGTTGGAAT	0.318		NaN											0	0	0	0.021553	0	6	64									
ZIC1	7545	broad.mit.edu	37	3	147128234	147128234	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr3:147128234C>T	uc003ewe.2	+	1	1054	c.335C>T	c.(334-336)GCG>GTG	p.A112V		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	112	Poly-Ala.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GACGCGGCGGCGGCAGCCAGC	0.701		NaN											0	0	0	0.038147	0	7	70									
DGKQ	1609	broad.mit.edu	37	4	961427	961427	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr4:961427C>T	uc003gbw.2	-	8	971	c.897G>A	c.(895-897)ACG>ACA	p.T299T	DGKQ_uc010ibn.2_Silent_p.T299T	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	299					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGATCTTCAGCGTTTGCTTCC	0.667		NaN											0	0	0	0.132662	0	14	16									
NSUN7	79730	broad.mit.edu	37	4	40752759	40752759	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr4:40752759G>A	uc003gvj.3	+	2	544	c.49G>A	c.(49-51)GAG>AAG	p.E17K	NSUN7_uc003gvh.2_Missense_Mutation_p.E17K|NSUN7_uc003gvi.3_Missense_Mutation_p.E17K	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						AGAAGATCCCGAGATCATCTC	0.552		NaN											0	0	0	0.069288	0	23	46									
IGJ	3512	broad.mit.edu	37	4	71522981	71522981	+	Silent	SNP	G	G	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr4:71522981G>T	uc003hfn.3	-	3	357	c.216C>A	c.(214-216)ATC>ATA	p.I72I	IGJ_uc010ihz.2_Silent_p.I88I	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	72					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			TGGGATCAGAGATATTCTCCC	0.323		NaN											1	0	1.96292e-10	0.055883	2.13612e-10	18	70									
PCDHA9	9752	broad.mit.edu	37	5	140229323	140229323	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:140229323C>T	uc003lhu.2	+	1	1967	c.1243C>T	c.(1243-1245)CGC>TGC	p.R415C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.R415C	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	415	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTCTGGACCGCGAGAGTGT	0.642		NaN											0	0	0	0.163468	0	33	125									
PCDHA9	9752	broad.mit.edu	37	5	140229587	140229587	+	Missense_Mutation	SNP	T	T	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:140229587T>G	uc003lhu.2	+	1	2231	c.1507T>G	c.(1507-1509)TCG>GCG	p.S503A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.S503A	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGAGCGCTCGCTGTCGAG	0.672		NaN											0	0	0	0.173368	0	30	167									
PRR7	80758	broad.mit.edu	37	5	176882976	176882976	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:176882976C>T	uc003mgu.1	+	4	1171	c.679C>T	c.(679-681)CCA>TCA	p.P227S	PRR7_uc003mgv.1_Missense_Mutation_p.P227S|PRR7_uc003mgw.1_Missense_Mutation_p.P227S	NM_030567	NP_085044	Q8TB68	PRR7_HUMAN	proline rich 7 (synaptic)	227	Pro-rich.|Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane					0	all_cancers(89;1.51e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGCCCTGCCCAGCCCTCTG	0.746		NaN											0	0	0	0.02938	0	7	5									
ZNF354A	6940	broad.mit.edu	37	5	178139989	178139989	+	Missense_Mutation	SNP	G	G	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:178139989G>C	uc003mjj.2	-	5	1088	c.890C>G	c.(889-891)TCC>TGC	p.S297C		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	297					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		ACATCTGTAGGATTTCTCCAC	0.378		NaN											0	0	0	0.076483	0	24	78									
DSP	1832	broad.mit.edu	37	6	7580718	7580718	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr6:7580718A>C	uc003mxp.1	+	23	4574	c.4295A>C	c.(4294-4296)CAG>CCG	p.Q1432P	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1432	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GACATCCAACAGCAAAAGGCC	0.488		NaN											0	0	0	0.049695	0	19	63									
RIMS1	22999	broad.mit.edu	37	6	72889512	72889512	+	Missense_Mutation	SNP	A	A	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr6:72889512A>T	uc003pga.2	+	5	783	c.706A>T	c.(706-708)AGC>TGC	p.S236C	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	236					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGCTCCTCCCAGCGCACCACC	0.587		NaN											0	0	0	0.104719	0	41	22									
BBS9	27241	broad.mit.edu	37	7	33217147	33217147	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:33217147A>G	uc003tdn.1	+	5	899	c.386A>G	c.(385-387)CAT>CGT	p.H129R	BBS9_uc003tdo.1_Missense_Mutation_p.H129R|BBS9_uc003tdp.1_Missense_Mutation_p.H129R|BBS9_uc003tdq.1_Missense_Mutation_p.H129R|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.H129R|BBS9_uc011kao.1_Missense_Mutation_p.H7R	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	129					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			ATGTATGAACATAATCTTCAG	0.343		NaN							Bardet-Biedl_syndrome				0	0	0	0.139131	0	51	55									
POU6F2	11281	broad.mit.edu	37	7	39472816	39472816	+	Silent	SNP	G	G	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:39472816G>T	uc003thb.1	+	7	1209	c.1167G>T	c.(1165-1167)GGG>GGT	p.G389G		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	389	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CAGTCATTGGGAACCAGATCC	0.612		NaN											1	0	5.50884e-06	0.09319	5.71477e-06	12	76									
ST7	7982	broad.mit.edu	37	7	116869933	116869933	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:116869933A>C	uc011knn.1	+	14	1465	c.1460A>C	c.(1459-1461)CAC>CCC	p.H487P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TCCTCCACTCACCTCACCCGC	0.522		NaN											0	0	0	0.124865	0	26	55									
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507		NaN											0	0	0	0.139131	0	18	50									
SSPO	23145	broad.mit.edu	37	7	149508082	149508082	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:149508082G>A	uc010lpk.2	+	67	9476	c.9476G>A	c.(9475-9477)CGT>CAT	p.R3159H		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3159					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACTGTGGTTCGTCCATGTGAA	0.607		NaN											0	0	0	0.080935	0	12	36									
C8orf74	203076	broad.mit.edu	37	8	10555320	10555320	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr8:10555320C>T	uc003wtd.1	+	3	482	c.453C>T	c.(451-453)CTC>CTT	p.L151L	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	151											0				COAD - Colon adenocarcinoma(149;0.0811)		CCCATCCCCTCCCGCTGGCCG	0.652		NaN											0	0	0	0.183431	0	34	38									
ZHX2	22882	broad.mit.edu	37	8	123965291	123965291	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr8:123965291C>T	uc003ypk.1	+	3	2108	c.1541C>T	c.(1540-1542)GCG>GTG	p.A514V		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	514						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			TTGGCCATCGCGGCCTCCCGA	0.537		NaN											0	0	0	0.163468	0	33	18									
EPPK1	83481	broad.mit.edu	37	8	144940347	144940347	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr8:144940347C>T	uc003zaa.1	-	2	15098	c.15085G>A	c.(15085-15087)GTG>ATG	p.V5029M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5029	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCACGTCCACGGGCACGCGG	0.692		NaN											0	0	0	0.139131	0	49	731									
TLE1	7088	broad.mit.edu	37	9	84300624	84300624	+	Missense_Mutation	SNP	C	C	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:84300624C>A	uc004aly.2	-	4	642	c.201G>T	c.(199-201)ATG>ATT	p.M67I	TLE1_uc004alz.2_Missense_Mutation_p.M67I|TLE1_uc011lsr.1_Missense_Mutation_p.M67I|TLE1_uc004ama.1_Missense_Mutation_p.M67I|TLE1_uc011lss.1_Missense_Mutation_p.M67I|TLE1_uc004amb.2_Missense_Mutation_p.M67I	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	67	Gln-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						ATCCATATGACATTTCATAAT	0.294		NaN											1	0	5.9392e-07	0.021553	6.27858e-07	5	11									
HABP4	22927	broad.mit.edu	37	9	99250477	99250477	+	Missense_Mutation	SNP	G	G	A	rs141094261	byFrequency	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:99250477G>A	uc010msg.2	+	7	1254	c.1106G>A	c.(1105-1107)CGT>CAT	p.R369H	HABP4_uc010msh.2_Missense_Mutation_p.R264H	NM_014282	NP_055097	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	369					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				CGTCCTGGGCGTGGAGCCAGA	0.552		NaN											0	0	0	0.055883	0	22	33									
SVEP1	79987	broad.mit.edu	37	9	113168736	113168736	+	Silent	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:113168736G>A	uc010mtz.2	-	38	9481	c.9144C>T	c.(9142-9144)GCC>GCT	p.A3048A	SVEP1_uc010mty.2_Silent_p.A974A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3048	Sushi 27.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACTGGCCATCGGCTTCACAGG	0.498		NaN											0	0	0	0.055883	0	20	50									
PAPPA	5069	broad.mit.edu	37	9	119115032	119115032	+	Missense_Mutation	SNP	C	C	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:119115032C>G	uc004bjn.2	+	16	4393	c.4012C>G	c.(4012-4014)CCA>GCA	p.P1338A	PAPPA_uc011lxq.1_Missense_Mutation_p.P713A	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1338	Sushi 2.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGGTCCTTCCCAGAGGCCCT	0.602		NaN											0	0	0	0.0918	0	24	21									
SNAPC4	6621	broad.mit.edu	37	9	139273307	139273307	+	Missense_Mutation	SNP	G	G	A			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:139273307G>A	uc004chh.2	-	21	2981	c.2972C>T	c.(2971-2973)CCT>CTT	p.P991L		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	991	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TGAGAAGACAGGAGCGAGGGG	0.667		NaN											0	0	0	0.02938	0	7	7									
DMD	1756	broad.mit.edu	37	X	32486811	32486811	+	Missense_Mutation	SNP	A	A	G			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:32486811A>G	uc004dda.1	-	23	3210	c.2966T>C	c.(2965-2967)CTG>CCG	p.L989P	DMD_uc004dcz.2_Missense_Mutation_p.L866P|DMD_uc004dcy.1_Missense_Mutation_p.L985P|DMD_uc004ddb.1_Missense_Mutation_p.L981P|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	989	Spectrin 6.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGCTCTTGCAGAGAACTTTG	0.328		NaN											0	0	0	0.105934	0	14	50									
BMP15	9210	broad.mit.edu	37	X	50659529	50659529	+	Silent	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:50659529C>T	uc011mnw.1	+	2	1101	c.1101C>T	c.(1099-1101)GTC>GTT	p.V367V		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	367					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					CAATTAGTGTCCTTATGATTG	0.463		NaN											0	0	0	0.076483	0	25	97									
RGAG4	340526	broad.mit.edu	37	X	71351227	71351227	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:71351227C>T	uc010nlh.1	-	1	525	c.164G>A	c.(163-165)CGC>CAC	p.R55H	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	55										ovary(2)|skin(1)	3	Renal(35;0.156)					TACTGGCCAGCGGATGTAGCT	0.587		NaN											0	0	0	0.055883	0	19	50									
TBX22	50945	broad.mit.edu	37	X	79283540	79283540	+	Missense_Mutation	SNP	C	C	T			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:79283540C>T	uc010nmg.1	+	8	1048	c.914C>T	c.(913-915)ACT>ATT	p.T305I	TBX22_uc004edi.1_Missense_Mutation_p.T185I|TBX22_uc004edj.1_Missense_Mutation_p.T305I	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	305					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CCTTCTTTCACTCTCGATTTT	0.383		NaN											0	0	0	0.069234	0	11	15									
RBM17	84991	broad.mit.edu	37	10	6139098	6139098	+	Frame_Shift_Del	DEL	A	A	-			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:6139098delA	uc001ijb.2	+	2	296	c.70delA	c.(70-72)AAAfs	p.K24fs	RBM17_uc010qav.1_Frame_Shift_Del_p.K24fs	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	24					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						CAAAAACTTCAAACTTCTGCA	0.478		NaN											NaN	NaN	NaN	NaN	NaN	32	101	---	---							
NTF3	4908	broad.mit.edu	37	12	5603608	5603609	+	Frame_Shift_Ins	INS	-	-	C			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:5603608_5603609insC	uc001qnl.3	+	1	311_312	c.228_229insC	c.(226-231)GGGCCCfs	p.G76fs	NTF3_uc001qnk.3_Frame_Shift_Ins_p.G89fs	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	76_77					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						AGCGGGGAGGGCCCGCCAAGTC	0.579		NaN											NaN	NaN	NaN	NaN	NaN	37	87	---	---							
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr22:41650469_41650471delTCC	uc003azs.2	-	10	2571_2573	c.1101_1103delGGA	c.(1099-1104)GAGGAA>GAA	p.367_368EE>E	RANGAP1_uc003azt.2_In_Frame_Del_p.367_368EE>E|RANGAP1_uc003azu.2_In_Frame_Del_p.367_368EE>E|RANGAP1_uc003azr.2_5'Flank|RANGAP1_uc010gyk.2_5'Flank|RANGAP1_uc011aoz.1_In_Frame_Del_p.312_313EE>E	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	367_368	Asp/Glu-rich (highly acidic).|Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						ctcttctccttcctcctcctcct	0.266		NaN											NaN	NaN	NaN	NaN	NaN	8	120	---	---