Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
TAS1R3	83756	broad.mit.edu	37	1	1268732	1268732	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:1268732G>A	uc010nyk.1	+	5	1573	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	525	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGTGGACTGCGAGGCGGGCAG	0.692		NaN											0	0	0	0.001984	0	7	21									
PRDM16	63976	broad.mit.edu	37	1	3102752	3102752	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:3102752C>A	uc001akf.2	+	2	181	c.101C>A	c.(100-102)GCG>GAG	p.A34E	PRDM16_uc001akc.2_Missense_Mutation_p.A34E|PRDM16_uc001akd.2_Missense_Mutation_p.A34E|PRDM16_uc001ake.2_Missense_Mutation_p.A34E|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	34					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCCACAGCGCGGAGGACGAG	0.642		NaN	T	EVI1	MDS|AML								1	0	1.33834e-09	0.007413	1.79893e-09	17	111									
C1orf127	148345	broad.mit.edu	37	1	11007721	11007721	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:11007721C>T	uc010oao.1	-	8	2029	c.2024G>A	c.(2023-2025)TGA>TAA	p.*675*	C1orf127_uc001arr.1_Silent_p.*657*|C1orf127_uc001ars.1_Silent_p.*649*	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	675										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CATGGAGGCTCAGCGTGAGGG	0.637		NaN											0	0	0	0.009096	0	4	20									
MIIP	60672	broad.mit.edu	37	1	12090089	12090089	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:12090089A>T	uc001ato.1	+	8	1030	c.850A>T	c.(850-852)AGC>TGC	p.S284C		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	284										ovary(1)	1						GCGCAGGGTGAGCATCCCGCT	0.667		NaN											0	0	0	0.007413	0	19	83									
VPS13D	55187	broad.mit.edu	37	1	12429573	12429573	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:12429573G>T	uc001atv.2	+	54	10765	c.10624G>T	c.(10624-10626)GAA>TAA	p.E3542*	VPS13D_uc001atw.2_Nonsense_Mutation_p.E3517*|VPS13D_uc001atx.2_Nonsense_Mutation_p.E2729*|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3541					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCTCCGGACTGAAGTGAAGCC	0.517		NaN											1	0	1.88708e-17	0.008361	2.62165e-17	28	181									
AADACL3	126767	broad.mit.edu	37	1	12785550	12785550	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:12785550G>A	uc009vnn.1	+	4	873	c.640G>A	c.(640-642)GCC>ACC	p.A214T	AADACL3_uc001aug.1_Missense_Mutation_p.A144T	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	214							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CATGAAAGGTGCCCATTTGCC	0.483		NaN											0	0	0	0.01441	0	76	61									
LOC440563	440563	broad.mit.edu	37	1	13183214	13183214	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:13183214G>A	uc010obg.1	-	1	754	c.659C>T	c.(658-660)TCA>TTA	p.S220L		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	220						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CTCCTCTTCTGACTTAGCATT	0.458		NaN											0	0	0	0.00874	0	36	120									
CELA2B	51032	broad.mit.edu	37	1	15813791	15813791	+	Silent	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:15813791T>A	uc001awl.2	+	7	676	c.651T>A	c.(649-651)GGT>GGA	p.G217G		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	217	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GAGACTCCGGTGGGCCGCTGA	0.562		NaN											0	0	0	0.015359	0	30	137									
PLEKHM2	23207	broad.mit.edu	37	1	16060340	16060340	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:16060340T>G	uc010obo.1	+	20	3198	c.2971T>G	c.(2971-2973)TTC>GTC	p.F991V	SLC25A34_uc001axb.1_5'Flank	NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	991					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		CAAGAAGAAATTCGAGGATGC	0.642		NaN											0	0	0	0.017118	0	34	130									
EPHA2	1969	broad.mit.edu	37	1	16459810	16459810	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:16459810C>A	uc001aya.1	-	11	2055	c.1918G>T	c.(1918-1920)GAG>TAG	p.E640*		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	640	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACCGGCACCTCCTTCTTCCCC	0.627		NaN											1	0	9.86323e-18	0.021523	1.37256e-17	22	113									
ATP13A2	23400	broad.mit.edu	37	1	17314949	17314949	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:17314949C>G	uc001baa.2	-	24	2820	c.2630G>C	c.(2629-2631)GGA>GCA	p.G877A	ATP13A2_uc001azz.1_Missense_Mutation_p.G24A|ATP13A2_uc001bab.2_Missense_Mutation_p.G872A|ATP13A2_uc001bac.2_Missense_Mutation_p.G833A	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	877	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		GGCGCCGTCTCCGCACATGCC	0.592		NaN											0	0	0	0.015359	0	32	141									
UBR4	23352	broad.mit.edu	37	1	19441311	19441311	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:19441311C>T	uc001bbi.2	-	75	11200	c.11196G>A	c.(11194-11196)CGG>CGA	p.R3732R	UBR4_uc001bbj.1_Silent_p.R147R	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3732					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCACCTTCTTCCGGTCTTCTT	0.522		NaN											0	0	0	0.007835	0	33	183									
TMCO4	255104	broad.mit.edu	37	1	20107215	20107215	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:20107215G>C	uc001bcn.2	-	4	279	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	TMCO4_uc001bcm.2_Missense_Mutation_p.Q13E|TMCO4_uc001bco.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcp.1_Missense_Mutation_p.Q13E|TMCO4_uc009vpn.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcq.1_Missense_Mutation_p.Q13E	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	13						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGAGGCTGCTGAGGCAGCCTC	0.498		NaN											0	0	0	0.001168	0	6	46									
KIF17	57576	broad.mit.edu	37	1	21042025	21042025	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:21042025G>C	uc001bdr.3	-	2	457	c.339C>G	c.(337-339)ATC>ATG	p.I113M	KIF17_uc001bds.3_Missense_Mutation_p.I113M	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	113	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CCCTGGGGATGATGCCTCTCT	0.652		NaN											0	0	0	0.004656	0	25	107									
RPL11	6135	broad.mit.edu	37	1	24021182	24021182	+	Silent	SNP	C	C	T	rs1059937		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:24021182C>T	uc001bhk.2	+	4	317	c.297C>T	c.(295-297)TTC>TTT	p.F99F	RPL11_uc001bhl.2_Silent_p.F98F|RPL11_uc001bhm.2_Silent_p.F88F|RPL11_uc001bhn.1_Silent_p.F88F	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	99					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		AAAACAACTTCTCAGATACTG	0.438		NaN											0	0	0	0.01441	0	84	60									
RPL11	6135	broad.mit.edu	37	1	24021260	24021260	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:24021260C>G	uc001bhk.2	+	4	395	c.375C>G	c.(373-375)ATC>ATG	p.I125M	RPL11_uc001bhl.2_Missense_Mutation_p.I124M|RPL11_uc001bhm.2_Missense_Mutation_p.I114M|RPL11_uc001bhn.1_Missense_Mutation_p.I114M	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	125					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		GCATTGGTATCTACGGCCTGG	0.403		NaN											0	0	0	0.01441	0	78	69									
CSMD2	114784	broad.mit.edu	37	1	34208917	34208917	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:34208917A>T	uc001bxn.1	-	14	2046	c.2017T>A	c.(2017-2019)TCC>ACC	p.S673T	CSMD2_uc001bxm.1_Missense_Mutation_p.S713T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	673	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTCCCTGTGGAGTGGTCAGTC	0.597		NaN											0	0	0	0.020292	0	14	49									
CSMD2	114784	broad.mit.edu	37	1	34291361	34291361	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:34291361C>G	uc001bxn.1	-	7	957	c.928G>C	c.(928-930)GAG>CAG	p.E310Q	CSMD2_uc001bxm.1_Missense_Mutation_p.E350Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	310	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GACTTCAACTCAATTTGCTTC	0.537		NaN											0	0	0	0.006214	0	9	43									
ZMYM1	79830	broad.mit.edu	37	1	35576046	35576046	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:35576046C>T	uc001bym.2	+	8	1107	c.959C>T	c.(958-960)TCA>TTA	p.S320L	ZMYM1_uc001byn.2_Missense_Mutation_p.S320L|ZMYM1_uc010ohu.1_Missense_Mutation_p.S320L|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.S245L	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	320	MYM-type 4.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GAATCTTCTTCAGGTAATGTT	0.289		NaN											0	0	0	0.003163	0	16	102									
ZMYM1	79830	broad.mit.edu	37	1	35579264	35579264	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:35579264C>T	uc001bym.2	+	11	1981	c.1833C>T	c.(1831-1833)TTC>TTT	p.F611F	ZMYM1_uc001byn.2_Silent_p.F611F|ZMYM1_uc010ohu.1_Silent_p.F592F|ZMYM1_uc001byo.2_Silent_p.F251F|ZMYM1_uc009vut.2_Silent_p.F536F	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	611						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAGTTGACTTCTATAACAGTA	0.299		NaN											0	0	0	0.004007	0	15	54									
ZMYM1	79830	broad.mit.edu	37	1	35580694	35580694	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:35580694C>A	uc001bym.2	+	11	3411	c.3263C>A	c.(3262-3264)TCT>TAT	p.S1088Y	ZMYM1_uc001byn.2_Missense_Mutation_p.S1088Y|ZMYM1_uc010ohu.1_Missense_Mutation_p.S1069Y|ZMYM1_uc001byo.2_Missense_Mutation_p.S728Y|ZMYM1_uc009vut.2_Missense_Mutation_p.S1013Y	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	1088						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AACTCATTTTCTACCCTGCCT	0.398		NaN											1	0	3.08376e-08	0.01892	4.11168e-08	25	107									
EIF2C4	192670	broad.mit.edu	37	1	36298149	36298149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:36298149C>T	uc001bzj.1	+	11	1547	c.1357C>T	c.(1357-1359)CAA>TAA	p.Q453*		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	453					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACCTCAGAAACAATGTAGGGA	0.398		NaN											0	0	0	0.005443	0	26	75									
HIVEP3	59269	broad.mit.edu	37	1	41978764	41978764	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:41978764C>G	uc001cgz.3	-	8	7341	c.6128G>C	c.(6127-6129)AGA>ACA	p.R2043T	HIVEP3_uc001cha.3_Missense_Mutation_p.R2043T|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2043					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGCCAGTTCTCTTCCCAGGGG	0.637		NaN											0	0	0	0.01892	0	22	100									
CCDC23	374969	broad.mit.edu	37	1	43282117	43282117	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:43282117C>G	uc001cib.2	-	2	334	c.99G>C	c.(97-99)CAG>CAC	p.Q33H	ERMAP_uc010ojw.1_5'Flank|ERMAP_uc001cic.1_5'Flank|ERMAP_uc001cid.1_5'Flank	NM_199342	NP_955374	Q8N300	CCD23_HUMAN	coiled-coil domain containing 23	33	Potential.										0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTTTGTCTCTGCTTCAGCT	0.473		NaN											0	0	0	0.01441	0	45	247									
C1orf83	127428	broad.mit.edu	37	1	54520107	54520107	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:54520107C>A	uc001cwt.1	+	2	212	c.12C>A	c.(10-12)TTC>TTA	p.F4L	C1orf83_uc001cwu.1_RNA|TMEM59_uc001cwp.2_5'Flank|TMEM59_uc001cwq.2_5'Flank|TMEM59_uc001cwr.2_5'Flank|TMEM59_uc001cws.1_5'Flank	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	4					transcription, DNA-dependent	nucleus	DNA binding				0						TGGATAAATTCGTCATTCGAA	0.478		NaN											1	0	0.000308642	0.003163	0.000392558	14	70									
RAVER2	55225	broad.mit.edu	37	1	65273062	65273062	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:65273062C>T	uc001dbs.1	+	9	1624	c.1546C>T	c.(1546-1548)CTT>TTT	p.L516F	RAVER2_uc001dbt.1_Missense_Mutation_p.L408F|RAVER2_uc010opb.1_Intron	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	529						cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						GCAGCCTTATCTTCAGAGCTT	0.532		NaN											0	0	0	0.008291	0	11	99									
IL23R	149233	broad.mit.edu	37	1	67724193	67724193	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:67724193T>G	uc001ddo.2	+	11	1357	c.1272T>G	c.(1270-1272)AGT>AGG	p.S424R	IL23R_uc009waz.2_Missense_Mutation_p.S221R|IL23R_uc001ddp.2_Intron|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Missense_Mutation_p.S22R|IL23R_uc010opk.1_3'UTR|IL23R_uc010opl.1_Missense_Mutation_p.S6R|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Missense_Mutation_p.S170R|IL23R_uc010opn.1_Missense_Mutation_p.S269R|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Intron|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Intron|IL23R_uc010opr.1_Intron|IL23R_uc010ops.1_Missense_Mutation_p.S221R|IL23R_uc010opt.1_Missense_Mutation_p.S65R|IL23R_uc010opu.1_Missense_Mutation_p.S120R|IL23R_uc010opv.1_Missense_Mutation_p.S182R|IL23R_uc010opw.1_Missense_Mutation_p.S59R|IL23R_uc010opx.1_Missense_Mutation_p.S65R|IL23R_uc010opy.1_Missense_Mutation_p.S191R|IL23R_uc010opz.1_Missense_Mutation_p.S65R|IL23R_uc010oqa.1_Missense_Mutation_p.S65R|IL23R_uc010oqb.1_Missense_Mutation_p.S253R|IL23R_uc010oqc.1_Missense_Mutation_p.S140R|IL23R_uc010oqd.1_Missense_Mutation_p.S59R|IL23R_uc010oqe.1_Missense_Mutation_p.S22R|IL23R_uc010oqf.1_Missense_Mutation_p.S22R|IL23R_uc010oqg.1_Missense_Mutation_p.S22R|IL23R_uc010oqh.1_Missense_Mutation_p.S65R|IL23R_uc001dds.2_Missense_Mutation_p.S169R|IL23R_uc001ddt.2_Missense_Mutation_p.S22R	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	424	Cytoplasmic (Potential).				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						ATAATTCCAGTGAGCAGGTCC	0.343		NaN											0	0	0	0.021523	0	22	180									
LRRC7	57554	broad.mit.edu	37	1	70504754	70504754	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:70504754G>A	uc001dep.2	+	19	3163	c.3133G>A	c.(3133-3135)GAA>AAA	p.E1045K	LRRC7_uc009wbg.2_Missense_Mutation_p.E329K|LRRC7_uc001deq.2_Missense_Mutation_p.E286K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1045						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AGTGAAAGCCGAAAAGAGGAT	0.438		NaN											0	0	0	0.010729	0	11	33									
LRRIQ3	127255	broad.mit.edu	37	1	74507428	74507428	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:74507428T>A	uc001dfy.3	-	7	1379	c.1187A>T	c.(1186-1188)AAA>ATA	p.K396I	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	396										ovary(2)	2						TCGTATGTCTTTTTTAATGAT	0.343		NaN											0	0	0	0.013537	0	12	71									
FPGT	8790	broad.mit.edu	37	1	74670357	74670357	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:74670357A>G	uc001dgb.1	+	4	663	c.626A>G	c.(625-627)GAT>GGT	p.D209G	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	209					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TTTGTCTTAGATCCTTTTGAT	0.378		NaN											0	0	0	0.020292	0	13	111									
LPHN2	23266	broad.mit.edu	37	1	82421724	82421724	+	Nonsense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:82421724C>G	uc001dit.3	+	10	2127	c.1946C>G	c.(1945-1947)TCA>TGA	p.S649*	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Nonsense_Mutation_p.S649*|LPHN2_uc001div.2_Nonsense_Mutation_p.S649*|LPHN2_uc009wcd.2_Nonsense_Mutation_p.S649*|LPHN2_uc001diw.2_Nonsense_Mutation_p.S233*	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	662	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding	p.S649S(1)		ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACAAGGGTCTCAATGCCCACA	0.353		NaN											0	0	0	0.007413	0	15	19									
TTLL7	79739	broad.mit.edu	37	1	84335732	84335732	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:84335732C>G	uc001djc.2	-	21	2973	c.2577G>C	c.(2575-2577)TTG>TTC	p.L859F	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_Intron	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	859					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTGGTGTTCTCAAGAAGAATT	0.368		NaN											0	0	0	0.020292	0	15	12									
LPAR3	23566	broad.mit.edu	37	1	85331077	85331077	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:85331077T>C	uc001dkl.2	-	1	766	c.727A>G	c.(727-729)ACT>GCT	p.T243A	LPAR3_uc009wcj.1_Missense_Mutation_p.T243A	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	243	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						CCTAAGACAGTCATCACCGTC	0.368		NaN											0	0	0	0.014758	0	4	18									
HFM1	164045	broad.mit.edu	37	1	91784914	91784914	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:91784914T>C	uc001doa.3	-	24	2716	c.2616A>G	c.(2614-2616)ATA>ATG	p.I872M	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.I551M|HFM1_uc001dob.3_Missense_Mutation_p.I104M|HFM1_uc010osv.1_Missense_Mutation_p.I556M	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	872	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CAAAATCTTGTATGGGAATGC	0.353		NaN											0	0	0	0.010504	0	19	13									
TGFBR3	7049	broad.mit.edu	37	1	92178024	92178024	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:92178024C>G	uc001doh.2	-	13	2408	c.1942G>C	c.(1942-1944)GAT>CAT	p.D648H	TGFBR3_uc009wde.2_Intron|TGFBR3_uc010osy.1_Missense_Mutation_p.D606H|TGFBR3_uc001doi.2_Missense_Mutation_p.D647H|TGFBR3_uc001doj.2_Missense_Mutation_p.D647H	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	648	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GACATCCTATCAGGGTTCGAA	0.393		NaN											0	0	0	0.013537	0	12	59									
NTNG1	22854	broad.mit.edu	37	1	107867236	107867236	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:107867236G>A	uc001dvh.3	+	3	1297	c.579G>A	c.(577-579)GTG>GTA	p.V193V	NTNG1_uc001dvf.3_Silent_p.V193V|NTNG1_uc010out.1_Silent_p.V193V|NTNG1_uc001dvc.3_Silent_p.V193V|NTNG1_uc001dvd.1_Silent_p.V193V	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	193	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CTAAATCCGTGAAGGATTTAT	0.398		NaN											0	0	0	0.001168	0	6	15									
RBM15	64783	broad.mit.edu	37	1	110882179	110882179	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:110882179C>A	uc001dzl.1	+	1	235	c.152C>A	c.(151-153)TCG>TAG	p.S51*	RBM15_uc001dzm.1_Nonsense_Mutation_p.S51*|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	51					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AAAGAGCGCTCGCCAGTGAAG	0.647		NaN	T	MKL1	acute megakaryocytic leukemia								1	0	0.00185496	0.016723	0.00234132	13	54									
SLC16A1	6566	broad.mit.edu	37	1	113460090	113460090	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:113460090C>A	uc001ecx.2	-	4	1770	c.938G>T	c.(937-939)CGA>CTA	p.R313L	SLC16A1_uc001ecy.2_Missense_Mutation_p.R313L|SLC16A1_uc001ecz.2_Missense_Mutation_p.R313L	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	313	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CATAGATGGTCGGGCTACCAT	0.433		NaN											1	0	3.59834e-05	0.001168	4.64808e-05	6	29									
CD2	914	broad.mit.edu	37	1	117297379	117297379	+	Nonsense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:117297379C>G	uc001egu.3	+	2	217	c.188C>G	c.(187-189)TCA>TGA	p.S63*	CD2_uc010owz.1_Nonsense_Mutation_p.S63*|CD2_uc010oxa.1_Nonsense_Mutation_p.S63*	NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	63	Extracellular (Potential).|LFA-3 (CD58) binding region 1.|Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GAAAAAACTTCAGACAAGAAA	0.348		NaN											0	0	0	0.001984	0	7	66									
ACP6	51205	broad.mit.edu	37	1	147126339	147126339	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:147126339G>T	uc001epr.2	-	6	1214	c.750C>A	c.(748-750)TTC>TTA	p.F250L	ACP6_uc009wjj.1_Missense_Mutation_p.F207L	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	250					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					CCAGGAGGATGAAGAAGTCCA	0.537		NaN											1	0	8.12818e-05	0.001984	0.000104505	7	128									
RPRD2	23248	broad.mit.edu	37	1	150444194	150444194	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:150444194G>A	uc009wlr.2	+	11	2971	c.2770G>A	c.(2770-2772)GGG>AGG	p.G924R	RPRD2_uc010pcc.1_Missense_Mutation_p.G898R|RPRD2_uc001eup.3_Missense_Mutation_p.G898R	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	924	Ser-rich.						protein binding			ovary(1)	1						GAATGAACCTGGGTCTGACCG	0.502		NaN											0	0	0	0.01441	0	81	288									
MCL1	4170	broad.mit.edu	37	1	150551725	150551725	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:150551725C>G	uc001euz.2	-	1	412	c.282G>C	c.(280-282)GCG>GCC	p.A94A	MCL1_uc010pch.1_5'UTR|MCL1_uc001eva.2_Silent_p.A94A	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	94					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AAAGCAGCCTCGCGGGGGTCG	0.751		NaN											0	0	0	0.00308	0	5	14									
FCER1A	2205	broad.mit.edu	37	1	159273962	159273962	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:159273962A>C	uc001ftq.2	+	4	420	c.321A>C	c.(319-321)GAA>GAC	p.E107D		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	107	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	TGTACCTGGAAGTCTTCAGTG	0.403		NaN											0	0	0	0.001984	0	6	87									
MPZ	4359	broad.mit.edu	37	1	161276626	161276626	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:161276626C>T	uc001gaf.3	-	3	387	c.350G>A	c.(349-351)TGG>TAG	p.W117*	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	107	Ig-like V-type.|Extracellular (Potential).				synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCCATCCTTCCAGCGAGGGTC	0.517		NaN											0	0	0	0.01441	0	54	478									
C1orf9	51430	broad.mit.edu	37	1	172526519	172526519	+	Silent	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:172526519T>A	uc001giq.3	+	5	859	c.543T>A	c.(541-543)GCT>GCA	p.A181A	C1orf9_uc010pmm.1_Silent_p.A181A|C1orf9_uc009wwd.2_Silent_p.A144A|C1orf9_uc010pmn.1_Silent_p.A144A|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	181					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		ATGCTAGTGCTCCAATTGAAC	0.433		NaN											0	0	0	0.01441	0	169	75									
DARS2	55157	broad.mit.edu	37	1	173810010	173810010	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:173810010G>C	uc001gjh.1	+	11	1437	c.1027G>C	c.(1027-1029)GAT>CAT	p.D343H		NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	343					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	CCAGATTATAGATATCAGTGA	0.323		NaN											0	0	0	0.016723	0	12	175									
ASTN1	460	broad.mit.edu	37	1	176913088	176913088	+	Silent	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:176913088G>T	uc001glc.2	-	14	2528	c.2316C>A	c.(2314-2316)CCC>CCA	p.P772P	ASTN1_uc001glb.1_Silent_p.P772P|ASTN1_uc001gld.1_Silent_p.P772P|ASTN1_uc009wwx.1_Silent_p.P772P	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	780					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GATTCTCCAGGGGCACAGTGG	0.512		NaN											1	0	3.45872e-05	0.004007	4.48172e-05	17	47									
SOAT1	6646	broad.mit.edu	37	1	179310346	179310346	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:179310346C>T	uc001gml.2	+	7	744	c.681C>T	c.(679-681)TTC>TTT	p.F227F	SOAT1_uc010pni.1_Silent_p.F162F|SOAT1_uc001gmm.2_Silent_p.F169F|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Silent_p.F162F	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	227					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GCTTTCTTTTCATGATCTTCC	0.433		NaN											0	0	0	0.01441	0	57	256									
MR1	3140	broad.mit.edu	37	1	181018405	181018405	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:181018405C>G	uc001goq.1	+	2	290	c.285C>G	c.(283-285)TTC>TTG	p.F95L	MR1_uc001gop.2_Missense_Mutation_p.F95L|MR1_uc001gor.1_Missense_Mutation_p.F95L|MR1_uc001gos.1_Missense_Mutation_p.F95L|MR1_uc010pns.1_Missense_Mutation_p.F95L	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	95	Extracellular (Potential).|Ligand-binding.|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						AGCAGATGTTCAAGGTGGAAC	0.617		NaN											0	0	0	0.004482	0	8	44									
NCF2	4688	broad.mit.edu	37	1	183532431	183532431	+	Missense_Mutation	SNP	G	G	A	rs145970396		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:183532431G>A	uc001gqj.3	-	13	1464	c.1189C>T	c.(1189-1191)CGG>TGG	p.R397W	NCF2_uc010pod.1_Missense_Mutation_p.R352W|NCF2_uc010poe.1_Missense_Mutation_p.R316W|NCF2_uc001gqk.3_Missense_Mutation_p.R397W	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	397	OPR.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						TTGCTGTCCCGAGGCCGATAG	0.522		NaN											0	0	0	0.010818	0	31	104									
CAMSAP1L1	23271	broad.mit.edu	37	1	200824006	200824006	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:200824006G>C	uc001gvl.2	+	15	4188	c.3918G>C	c.(3916-3918)AAG>AAC	p.K1306N	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.K1295N|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.K1279N	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1306						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ATTCAGGCAAGAGGACGCCAA	0.343		NaN											0	0	0	0.001168	0	6	21									
ATP2B4	493	broad.mit.edu	37	1	203678495	203678495	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:203678495T>G	uc001gzw.2	+	11	2508	c.1624T>G	c.(1624-1626)TTT>GTT	p.F542V	ATP2B4_uc001gzv.2_Missense_Mutation_p.F542V|ATP2B4_uc009xaq.2_Missense_Mutation_p.F542V	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	542	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCTGCTAGGCTTTGTCACAGA	0.512		NaN											0	0	0	0.013114	0	46	84									
FCAMR	83953	broad.mit.edu	37	1	207135777	207135777	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:207135777G>A	uc001hfa.3	-	5	933	c.433C>T	c.(433-435)CTG>TTG	p.L145L	FCAMR_uc001hfb.2_Silent_p.L145L|FCAMR_uc009xca.1_Silent_p.L145L|FCAMR_uc001hfc.2_Silent_p.L120L	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	100	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						GGGGGCCCCAGACGGCACCAG	0.577		NaN											0	0	0	0.004007	0	15	61									
C4BPA	722	broad.mit.edu	37	1	207286412	207286412	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:207286412A>C	uc001hfo.2	+	2	236	c.42A>C	c.(40-42)AAA>AAC	p.K14N		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	14					complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TTCATAGAAAAAGGAAAATGG	0.453		NaN											0	0	0	0.005443	0	27	29									
CD34	947	broad.mit.edu	37	1	208072532	208072532	+	Nonsense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:208072532G>C	uc001hgw.1	-	3	560	c.302C>G	c.(301-303)TCA>TGA	p.S101*	CD34_uc001hgx.1_Nonsense_Mutation_p.S101*|CD34_uc010psj.1_Intron	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	101	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						TCCATAAACTGAGGTTATCAC	0.448		NaN											0	0	0	0.007291	0	28	191									
USH2A	7399	broad.mit.edu	37	1	216052273	216052273	+	Silent	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:216052273T>A	uc001hku.1	-	42	8778	c.8391A>T	c.(8389-8391)TCA>TCT	p.S2797S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2797	Fibronectin type-III 14.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATTACCCCCTGAGCAAGCAA	0.448		NaN								HNSCC(13;0.011)			0	0	0	0.010729	0	10	53									
TP53BP2	7159	broad.mit.edu	37	1	223976866	223976866	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:223976866G>A	uc010pvb.1	-	16	3299	c.3007C>T	c.(3007-3009)CAT>TAT	p.H1003Y	TP53BP2_uc001hod.2_Missense_Mutation_p.H874Y|TP53BP2_uc010puz.1_Missense_Mutation_p.H236Y|TP53BP2_uc010pva.1_Missense_Mutation_p.H642Y	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	997	ANK 2.|Mediates interaction with APC2.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCAGCACAATGTAATGGAGTC	0.458		NaN											0	0	0	0.012319	0	19	88									
SIPA1L2	57568	broad.mit.edu	37	1	232596869	232596869	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:232596869C>T	uc001hvg.2	-	8	3017	c.2859G>A	c.(2857-2859)CTG>CTA	p.L953L	SIPA1L2_uc001hvf.2_Silent_p.L27L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	953	PDZ.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CGTTCCTCCTCAGGGTCATTT	0.562		NaN											0	0	0	0.01441	0	93	199									
SLC35F3	148641	broad.mit.edu	37	1	234452365	234452365	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:234452365C>T	uc001hwa.1	+	4	867	c.639C>T	c.(637-639)CTC>CTT	p.L213L	SLC35F3_uc001hvy.1_Silent_p.L282L	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	213	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CCGCCATCCTCGCCATCGCTG	0.577		NaN											0	0	0	0.01441	0	228	429									
PLD5	200150	broad.mit.edu	37	1	242383316	242383316	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:242383316C>A	uc001hzn.1	-	5	836	c.709G>T	c.(709-711)GGT>TGT	p.G237C	PLD5_uc001hzl.3_Missense_Mutation_p.G175C|PLD5_uc001hzm.3_Missense_Mutation_p.G27C|PLD5_uc001hzo.1_Missense_Mutation_p.G145C			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	237	PLD phosphodiesterase 1.					integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CAGTCCAAACCGGCACTGCCG	0.517		NaN											1	0	0.000602214	0.014758	0.000762437	5	43									
ZNF124	7678	broad.mit.edu	37	1	247323035	247323035	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:247323035G>C	uc001ick.2	-	2	250	c.111C>G	c.(109-111)CTC>CTG	p.L37L	ZNF124_uc001ici.2_RNA|ZNF124_uc001icj.1_Silent_p.L37L	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CGTCTCTATAGAGATTCTTCT	0.418		NaN											0	0	0	0.013726	0	33	61									
OR2AK2	391191	broad.mit.edu	37	1	248129260	248129260	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:248129260G>A	uc010pzd.1	+	1	627	c.627G>A	c.(625-627)CAG>CAA	p.Q209Q	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	209	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACACCTCCCAGTATGAGTATA	0.443		NaN											0	0	0	0.004007	0	17	28									
MAPK8	5599	broad.mit.edu	37	10	49633979	49633979	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:49633979C>G	uc009xnz.2	+	8	961	c.737C>G	c.(736-738)CCT>CGT	p.P246R	MAPK8_uc001jgl.2_Missense_Mutation_p.P246R|MAPK8_uc001jgm.2_Missense_Mutation_p.P246R|MAPK8_uc001jgo.2_Missense_Mutation_p.P246R|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.P246R|MAPK8_uc010qgk.1_Missense_Mutation_p.P246R|MAPK8_uc001jgp.2_Missense_Mutation_p.P246R|MAPK8_uc001jgq.2_Missense_Mutation_p.P246R	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	246	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		ACACCATGTCCTGAATTCATG	0.343		NaN											0	0	0	0.020292	0	13	18									
CTNNA3	29119	broad.mit.edu	37	10	67829226	67829226	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:67829226C>T	uc009xpn.1	-	15	2122	c.1999G>A	c.(1999-2001)GAG>AAG	p.E667K	CTNNA3_uc001jmw.2_Missense_Mutation_p.E667K	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	667					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TTTTCTGCCTCAGGCAGTTGA	0.348		NaN											0	0	0	0.001984	0	6	34									
HNRNPH3	3189	broad.mit.edu	37	10	70099239	70099239	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:70099239C>T	uc001jnw.3	+	6	795	c.566C>T	c.(565-567)TCA>TTA	p.S189L	HNRNPH3_uc001jnx.3_Missense_Mutation_p.S174L|HNRNPH3_uc009xpu.2_Missense_Mutation_p.S58L|HNRNPH3_uc010qiv.1_Missense_Mutation_p.S81L|HNRNPH3_uc001jny.3_Missense_Mutation_p.S140L	NM_012207	NP_036339	P31942	HNRH3_HUMAN	heterogeneous nuclear ribonucleoprotein H3	189	Gly-rich.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2						GATGCAAGTTCAGGTTTTCAT	0.378		NaN											0	0	0	0.006122	0	17	35									
ADAMTS14	140766	broad.mit.edu	37	10	72520585	72520585	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:72520585C>T	uc001jrh.2	+	22	3648	c.3648C>T	c.(3646-3648)CTC>CTT	p.L1216L	ADAMTS14_uc001jrg.2_Silent_p.L1219L	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1216	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GCACCAGCCTCCCTGCTGCCT	0.637		NaN											0	0	0	0.006122	0	18	23									
CDH23	64072	broad.mit.edu	37	10	73567089	73567089	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:73567089C>T	uc001jrx.3	+	56	8611	c.8234C>T	c.(8233-8235)ACC>ATC	p.T2745I	CDH23_uc001jsg.3_Missense_Mutation_p.T505I|CDH23_uc001jsh.3_Missense_Mutation_p.T505I|CDH23_uc001jsi.3_Missense_Mutation_p.T505I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2745	Cadherin 26.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCACGCGGCACCCTCGTGGGC	0.627		NaN											0	0	0	0.003163	0	16	17									
KIF20B	9585	broad.mit.edu	37	10	91477195	91477195	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:91477195C>G	uc001kgs.1	+	10	1139	c.1067C>G	c.(1066-1068)ACT>AGT	p.T356S	KIF20B_uc001kgr.1_Missense_Mutation_p.T356S	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	356	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AGCATATTCACTGTTAAAATA	0.254		NaN											0	0	0	0.004672	0	2	4									
ZNF518A	9849	broad.mit.edu	37	10	97919098	97919098	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:97919098G>C	uc001klp.2	+	6	3876	c.3019G>C	c.(3019-3021)GAG>CAG	p.E1007Q	ZNF518A_uc001klo.1_Missense_Mutation_p.E477Q|ZNF518A_uc001klq.2_Missense_Mutation_p.E1007Q|ZNF518A_uc001klr.2_Missense_Mutation_p.E1007Q	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1007					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TGTGACTAAGGAGCCTTGCAA	0.433		NaN											0	0	0	0.004672	0	3	23									
LCOR	84458	broad.mit.edu	37	10	98715326	98715326	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:98715326G>C	uc001kms.1	+	8	1470	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	LCOR_uc001kmr.2_Missense_Mutation_p.E317Q|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Missense_Mutation_p.E317Q|LCOR_uc001kmu.1_Missense_Mutation_p.E317Q	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	317						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTCAGATGCTGAGCAGTCTAC	0.483		NaN											0	0	0	0.004007	0	15	11									
RRP12	23223	broad.mit.edu	37	10	99160977	99160977	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:99160977C>T	uc001knf.2	-	1	151	c.12G>A	c.(10-12)TCG>TCA	p.S4S	RRP12_uc010qou.1_Silent_p.S4S|RRP12_uc009xvn.2_Silent_p.S4S	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	4						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GCAACTTTCCCGAGCGACCCA	0.587		NaN											0	0	0	0.006122	0	16	44									
PKD2L1	9033	broad.mit.edu	37	10	102057272	102057272	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:102057272G>A	uc001kqx.1	-	5	1206	c.823C>T	c.(823-825)CCA>TCA	p.P275S	PKD2L1_uc009xwm.1_Missense_Mutation_p.P228S	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	275	Extracellular (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CGGGATCCTGGAAGGTCCAGG	0.617		NaN											0	0	0	0.007291	0	27	43									
CPXM2	119587	broad.mit.edu	37	10	125506529	125506529	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:125506529G>T	uc001lhk.1	-	14	2347	c.2022C>A	c.(2020-2022)AAC>AAA	p.N674K	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	674					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		AATCCCCATCGTTGGCTGTGA	0.552		NaN											1	0	3.28513e-13	0.021523	4.48859e-13	24	208									
IFITM3	10410	broad.mit.edu	37	11	319922	319922	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:319922C>T	uc001lpa.2	-	2	419	c.318G>A	c.(316-318)CTG>CTA	p.L106L	uc001loz.2_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	interferon-induced transmembrane protein 3	106	Cytoplasmic (Potential).				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane				central_nervous_system(7)	7		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCCAGATGTTCAGGCACTTGG	0.587		NaN											0	0	0	0.01441	0	48	48									
OR51I2	390064	broad.mit.edu	37	11	5474803	5474803	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:5474803G>T	uc010qzf.1	+	1	85	c.85G>T	c.(85-87)GGG>TGG	p.G29W	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGCTGTCAGGGCCCCTCTG	0.547		NaN											1	0	9.31168e-06	0.016723	1.21418e-05	12	31									
NLRP10	338322	broad.mit.edu	37	11	7984932	7984932	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:7984932C>T	uc001mfv.1	-	1	128	c.111G>A	c.(109-111)CTG>CTA	p.L37L		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	37	DAPIN.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGCCCTCAGACAGGGTCATAT	0.542		NaN											0	0	0	0.016522	0	25	52									
RIC3	79608	broad.mit.edu	37	11	8132430	8132430	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:8132430C>A	uc001mgd.2	-	6	979	c.925G>T	c.(925-927)GAA>TAA	p.E309*	RIC3_uc001mgb.2_Nonsense_Mutation_p.E147*|RIC3_uc001mgc.2_Nonsense_Mutation_p.E308*|RIC3_uc001mge.2_Nonsense_Mutation_p.E127*|RIC3_uc010rbl.1_Nonsense_Mutation_p.E259*|RIC3_uc010rbm.1_Nonsense_Mutation_p.E337*|RIC3_uc009yfm.2_Nonsense_Mutation_p.E228*|RIC3_uc009yfn.2_Nonsense_Mutation_p.E112*	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	309	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		TCCTCGTCTTCATGAAAACAG	0.493		NaN											1	0	1.60099e-16	0.021022	2.21675e-16	36	78									
MICALCL	84953	broad.mit.edu	37	11	12315578	12315578	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:12315578G>C	uc001mkg.1	+	3	891	c.600G>C	c.(598-600)GAG>GAC	p.E200D		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	200					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		CCATCCCTGAGAGTGTGCACC	0.537		NaN											0	0	0	0.010818	0	31	85									
DBX1	120237	broad.mit.edu	37	11	20178727	20178727	+	Silent	SNP	C	C	T	rs143300593	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:20178727C>T	uc001mpw.1	-	3	528	c.528G>A	c.(526-528)GGG>GGA	p.G176G		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	176					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCGAGGCTTCCCGCGCGCGG	0.682		NaN											0	0	0	0.001168	0	6	10									
QSER1	79832	broad.mit.edu	37	11	32955355	32955355	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:32955355A>G	uc001mty.2	+	4	2431	c.2164A>G	c.(2164-2166)AAT>GAT	p.N722D	QSER1_uc001mtz.1_Missense_Mutation_p.N483D|QSER1_uc001mua.2_Missense_Mutation_p.N227D	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	722	Gln-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ATCTCTTCCTAATACACAGGT	0.413		NaN											0	0	0	0.00308	0	8	21									
C11orf74	119710	broad.mit.edu	37	11	36654908	36654908	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:36654908C>T	uc001mwy.1	+	3	284	c.211C>T	c.(211-213)CAT>TAT	p.H71Y	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Intron|C11orf74_uc001mwx.1_Intron|C11orf74_uc001mwz.1_Intron|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	71											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				AAAAGTTACTCATAAAAATGA	0.338		NaN											0	0	0	0.001168	0	5	24									
ZNF408	79797	broad.mit.edu	37	11	46726955	46726955	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:46726955C>T	uc001nde.1	+	5	1935	c.1705C>T	c.(1705-1707)CAC>TAC	p.H569Y	ZNF408_uc010rgw.1_Missense_Mutation_p.H561Y	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	569	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GCTCCGAGCTCACGAGCGCCT	0.657		NaN											0	0	0	0.001984	0	6	30									
PSMC3	5702	broad.mit.edu	37	11	47444417	47444417	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:47444417C>G	uc001nfh.2	-	7	893	c.699G>C	c.(697-699)AAG>AAC	p.K233N	PSMC3_uc009ylr.1_Missense_Mutation_p.K191N	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	233	ATP (Potential).			K->H: Loss of function.	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCAGGAGGGTCTTCCCCGTCC	0.582		NaN											0	0	0	0.006214	0	8	198									
NUP160	23279	broad.mit.edu	37	11	47819815	47819815	+	Splice_Site	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:47819815C>A	uc001ngm.2	-	25	3077	c.2992_splice	c.e25-1	p.A998_splice	NUP160_uc009ylw.2_Splice_Site	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						TTAGAGTAGCCTAAATATCAA	0.353		NaN											1	0	0.000157383	0.00308	0.000202036	8	40									
OR5T1	390155	broad.mit.edu	37	11	56043764	56043764	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:56043764C>A	uc001nio.1	+	1	650	c.650C>A	c.(649-651)TCT>TAT	p.S217Y		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTTGTGGGCTCTATTGAGATA	0.408		NaN											1	0	1.96292e-10	0.010504	2.65572e-10	21	97									
CLP1	10978	broad.mit.edu	37	11	57427259	57427259	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:57427259G>A	uc001nkw.2	+	2	450	c.311G>A	c.(310-312)CGG>CAG	p.R104Q	CLP1_uc010rjw.1_Missense_Mutation_p.R104Q|CLP1_uc009yml.2_Missense_Mutation_p.R104Q	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	104					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						GAACAGATGCGGAGGCAAGCG	0.547		NaN											0	0	0	0.021523	0	27	61									
CTNND1	1500	broad.mit.edu	37	11	57569394	57569394	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:57569394C>G	uc001nmc.3	+	7	1717	c.1146C>G	c.(1144-1146)GTC>GTG	p.V382V	CTNND1_uc001nlh.1_Silent_p.V382V|CTNND1_uc001nlu.3_Silent_p.V281V|CTNND1_uc001nlt.3_Silent_p.V281V|CTNND1_uc001nls.3_Silent_p.V281V|CTNND1_uc001nlw.3_Silent_p.V281V|CTNND1_uc001nmf.3_Silent_p.V382V|CTNND1_uc001nmd.3_Silent_p.V328V|CTNND1_uc001nlk.3_Silent_p.V328V|CTNND1_uc001nme.3_Silent_p.V382V|CTNND1_uc001nll.3_Silent_p.V328V|CTNND1_uc001nmg.3_Silent_p.V328V|CTNND1_uc001nlj.3_Silent_p.V328V|CTNND1_uc001nlr.3_Silent_p.V328V|CTNND1_uc001nlp.3_Silent_p.V328V|CTNND1_uc001nlx.3_Silent_p.V59V|CTNND1_uc001nlz.3_Silent_p.V59V|CTNND1_uc009ymn.2_Silent_p.V59V|CTNND1_uc001nlm.3_Silent_p.V382V|CTNND1_uc001nly.3_Silent_p.V59V|CTNND1_uc001nmb.3_Silent_p.V59V|CTNND1_uc001nma.3_Silent_p.V59V|CTNND1_uc001nmi.3_Silent_p.V281V|CTNND1_uc001nmh.3_Silent_p.V382V|CTNND1_uc001nlq.3_Silent_p.V281V|CTNND1_uc001nln.3_Silent_p.V382V|CTNND1_uc001nli.3_Silent_p.V382V|CTNND1_uc001nlo.3_Silent_p.V281V|CTNND1_uc001nlv.3_Silent_p.V281V	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	382	ARM 1.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				TGGATGCTGTCAAGTCCAATG	0.552		NaN											0	0	0	0.004007	0	16	94									
OR9Q1	219956	broad.mit.edu	37	11	57947582	57947582	+	Missense_Mutation	SNP	C	C	G	rs139135884	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:57947582C>G	uc001nmj.2	+	3	982	c.666C>G	c.(664-666)ATC>ATG	p.I222M		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TGTTTATCATCGTGGCCATCA	0.512		NaN											0	0	0	0.008361	0	26	93									
TMEM132A	54972	broad.mit.edu	37	11	60703933	60703933	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:60703933C>T	uc001nqj.2	+	11	2819	c.2626C>T	c.(2626-2628)CAG>TAG	p.Q876*	TMEM132A_uc001nqi.2_Nonsense_Mutation_p.Q877*|TMEM132A_uc001nqm.2_Nonsense_Mutation_p.Q86*	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	876	Binds to HSPA5/GRP78 (By similarity).|Cytoplasmic (Potential).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CCTGCGCTATCAGCGCAAAGA	0.607		NaN											0	0	0	0.01441	0	55	233									
TMEM216	51259	broad.mit.edu	37	11	61161357	61161357	+	Silent	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:61161357T>G	uc010rlj.1	+	3	410	c.117T>G	c.(115-117)GGT>GGG	p.G39G	TMEM216_uc001nrn.1_5'UTR	NM_016499	NP_057583	Q9P0N5	TM216_HUMAN	transmembrane protein 216	39						integral to membrane					0						TATTGGCAGGTGTCCTGCTAC	0.438		NaN											0	0	0	0.010818	0	17	67									
DAGLA	747	broad.mit.edu	37	11	61511216	61511216	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:61511216G>A	uc001nsa.2	+	20	2495	c.2384G>A	c.(2383-2385)CGC>CAC	p.R795H		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	795	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TTCGACTCGCGCCGCTCCTCA	0.682		NaN											0	0	0	0.010818	0	33	126									
MTA2	9219	broad.mit.edu	37	11	62364201	62364201	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:62364201C>T	uc001ntq.1	-	9	1171	c.790G>A	c.(790-792)GAG>AAG	p.E264K	MTA2_uc010rlx.1_Missense_Mutation_p.E91K	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	264	SANT.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCCTCCATCTCATCCCGACAC	0.537		NaN											0	0	0	0.01441	0	69	142									
PYGM	5837	broad.mit.edu	37	11	64522956	64522956	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:64522956C>A	uc001oax.3	-	6	1552	c.735G>T	c.(733-735)TGG>TGT	p.W245C	PYGM_uc001oay.3_Missense_Mutation_p.W157C	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	245					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CCTTGGCAGACCAGAGGCGCA	0.622		NaN											1	0	9.31168e-06	0.016723	1.21418e-05	12	85									
MAP4K2	5871	broad.mit.edu	37	11	64557220	64557220	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:64557220C>T	uc001obh.2	-	31	2449	c.2357G>A	c.(2356-2358)CGA>CAA	p.R786Q	MAP4K2_uc001obg.2_RNA|MAP4K2_uc001obi.2_Missense_Mutation_p.R778Q	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	786	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CCCAAGCACTCGGAAGATCCT	0.592		NaN											0	0	0	0.00632	0	25	123									
C11orf2	738	broad.mit.edu	37	11	64875784	64875784	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:64875784G>C	uc001ocr.1	+	5	881	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	C11orf2_uc001ocs.1_Missense_Mutation_p.E157Q	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	281	Potential.				lipid transport|protein transport	Golgi apparatus|integral to membrane					0						CGGCCGGCTGGAGAAGGAGCT	0.706		NaN											0	0	0	0.004482	0	8	45									
CDC42EP2	10435	broad.mit.edu	37	11	65088417	65088417	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:65088417C>T	uc001odl.2	+	2	498	c.48C>T	c.(46-48)GGC>GGT	p.G16G		NM_006779	NP_006770	O14613	BORG1_HUMAN	Cdc42 effector protein 2	16					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity				0						GTCGCAAGGGCAAGAAGGAGA	0.627		NaN											0	0	0	0.001168	0	6	58									
PC	5091	broad.mit.edu	37	11	66619932	66619932	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:66619932G>C	uc001ojn.1	-	13	1852	c.1803C>G	c.(1801-1803)CTC>CTG	p.L601L	PC_uc001ojo.1_Silent_p.L601L|PC_uc001ojp.1_Silent_p.L601L|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	601	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CCATGCTGAAGAGCTTGCTGA	0.622		NaN											0	0	0	0.001984	0	7	139									
CABP4	57010	broad.mit.edu	37	11	67223786	67223786	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:67223786C>T	uc001olo.2	+	3	491	c.414C>T	c.(412-414)TTC>TTT	p.F138F	CABP4_uc001oln.2_Silent_p.F33F	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	138	EF-hand 1.				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGGCCGCCTTCGAGGAGTTTG	0.652		NaN											0	0	0	0.012213	0	29	163									
NUMA1	4926	broad.mit.edu	37	11	71726086	71726086	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:71726086C>A	uc001orl.1	-	15	2635	c.2463G>T	c.(2461-2463)CAG>CAT	p.Q821H	NUMA1_uc009ysw.1_Missense_Mutation_p.Q384H|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Missense_Mutation_p.Q821H|NUMA1_uc001orn.2_Missense_Mutation_p.Q384H|NUMA1_uc009ysx.1_Missense_Mutation_p.Q821H|NUMA1_uc001oro.1_Missense_Mutation_p.Q821H	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	821	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCTCCTCTTGCTGGCTATCCT	0.577		NaN	T	RARA	APL								1	0	1.99505e-19	0.012213	2.7951e-19	33	255									
FOLR2	2350	broad.mit.edu	37	11	71932735	71932735	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:71932735G>C	uc009ytd.2	+	5	866	c.697G>C	c.(697-699)GAG>CAG	p.E233Q	FOLR2_uc009yte.2_Missense_Mutation_p.E233Q|FOLR2_uc001ose.3_Missense_Mutation_p.E233Q|FOLR2_uc009ytf.2_Missense_Mutation_p.E233Q	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	233					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)	GAATGCTGGTGAGATGCTTCA	0.587		NaN											0	0	0	0.013537	0	13	161									
ARRB1	408	broad.mit.edu	37	11	74977287	74977287	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:74977287G>A	uc001owe.1	-	16	1399	c.1177C>T	c.(1177-1179)CGC>TGC	p.R393C	ARRB1_uc001owf.1_Missense_Mutation_p.R385C	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	393	Interaction with TRAF6.|[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif.			R->A: Abolishes interaction with AP2B1.	G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						AGTCTCTGGCGAGCAAAGTCC	0.547		NaN											0	0	0	0.00632	0	28	152									
FAT3	120114	broad.mit.edu	37	11	92533025	92533025	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:92533025C>A	uc001pdj.3	+	9	6863	c.6846C>A	c.(6844-6846)GAC>GAA	p.D2282E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2282	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGTAAATGACAACCCCCCTA	0.423		NaN								TCGA Ovarian(4;0.039)			1	0	0.00024832	0.009096	0.000317298	4	14									
CASP5	838	broad.mit.edu	37	11	104877904	104877904	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:104877904C>T	uc010rva.1	-	3	371	c.339G>A	c.(337-339)CTG>CTA	p.L113L	CASP5_uc010ruz.1_Silent_p.L126L|CASP5_uc010rvb.1_Silent_p.L55L|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_5'UTR|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	113	CARD.				apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		CTACCAAGATCAGGGCCTTGT	0.368		NaN											0	0	0	0.013537	0	12	26									
RDX	5962	broad.mit.edu	37	11	110128893	110128893	+	Silent	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:110128893T>G	uc001pku.2	-	6	799	c.489A>C	c.(487-489)CTA>CTC	p.L163L	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Silent_p.L163L|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Silent_p.L131L|RDX_uc010rwe.1_Silent_p.L27L	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	163	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GTTCTTTTGTTAGTTTGTGTT	0.294		NaN											0	0	0	0.008291	0	9	34									
BUD13	84811	broad.mit.edu	37	11	116633707	116633707	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:116633707G>A	uc001ppn.2	-	4	632	c.598C>T	c.(598-600)CCT>TCT	p.P200S	BUD13_uc001ppo.2_Missense_Mutation_p.P200S|BUD13_uc009yzc.2_Missense_Mutation_p.P200S	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	200	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGGGAGAAGGATCTGGAGAA	0.567		NaN											0	0	0	0.005524	0	38	115									
SIDT2	51092	broad.mit.edu	37	11	117052804	117052804	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:117052804A>T	uc001pqh.1	+	4	540	c.499A>T	c.(499-501)ACA>TCA	p.T167S	SIDT2_uc010rxe.1_Missense_Mutation_p.T167S|SIDT2_uc001pqg.2_Missense_Mutation_p.T167S|SIDT2_uc001pqi.1_Missense_Mutation_p.T167S	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	167	Extracellular (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		CTTCAATACCACAGCAGCACA	0.597		NaN											0	0	0	0.00308	0	6	23									
CCDC84	338657	broad.mit.edu	37	11	118881534	118881534	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:118881534C>T	uc001pul.2	+	4	500	c.444C>T	c.(442-444)ATC>ATT	p.I148I	CCDC84_uc010ryk.1_RNA|CCDC84_uc010ryl.1_RNA|CCDC84_uc010rym.1_RNA	NM_198489	NP_940891	Q86UT8	CCD84_HUMAN	coiled-coil domain containing 84	148	Potential.									ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		ATAAAGTGATCAAGGAGGTAA	0.234		NaN											0	0	0	0.00308	0	7	41									
TECTA	7007	broad.mit.edu	37	11	121016422	121016422	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:121016422G>T	uc010rzo.1	+	11	3702	c.3702G>T	c.(3700-3702)CAG>CAT	p.Q1234H		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1234	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGAGCATGCAGAACAGCACCT	0.527		NaN											1	0	1.15919e-05	0.008871	1.50913e-05	20	71									
OR8B4	283162	broad.mit.edu	37	11	124294480	124294480	+	Silent	SNP	A	A	G	rs142136468		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:124294480A>G	uc010sak.1	-	1	288	c.288T>C	c.(286-288)TGT>TGC	p.C96C		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GCTGAGTCATACATCCCACAT	0.403		NaN											0	0	0	0.006214	0	10	37									
OPCML	4978	broad.mit.edu	37	11	132812893	132812893	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:132812893C>A	uc001qgs.2	-	1	145	c.95G>T	c.(94-96)CGC>CTC	p.R32L	OPCML_uc001qgu.2_Missense_Mutation_p.R25L|OPCML_uc010sck.1_Missense_Mutation_p.R32L|OPCML_uc001qgt.2_Missense_Mutation_p.R32L|OPCML_uc010scl.1_5'UTR	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	32					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ATCTCCGCTGCGCACGGGCAC	0.647		NaN											1	0	1.3268e-25	0.01441	1.87154e-25	54	30									
ERC1	23085	broad.mit.edu	37	12	1599298	1599298	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:1599298G>A	uc001qjb.2	+	19	3494	c.3253G>A	c.(3253-3255)GAA>AAA	p.E1085K	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.E1057K|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_3'UTR|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	1085	Potential.|FIP-RBD.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GGACAATGCAGAACTGCAGGA	0.483		NaN											0	0	0	0.006999	0	38	78									
PRMT8	56341	broad.mit.edu	37	12	3649850	3649850	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:3649850C>G	uc001qmf.2	+	2	521	c.154C>G	c.(154-156)CAA>GAA	p.Q52E	PRMT8_uc009zed.2_Missense_Mutation_p.Q43E|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	52					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			TGTGTCCACTCAACCCAGCTG	0.602		NaN											0	0	0	0.01441	0	54	339									
C12orf4	57102	broad.mit.edu	37	12	4599751	4599751	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:4599751G>A	uc001qms.2	-	13	1591	c.1503C>T	c.(1501-1503)TTC>TTT	p.F501F	C12orf4_uc001qmt.2_Silent_p.F501F	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	501											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		TTTCCATCATGAAACCTAAAA	0.388		NaN											0	0	0	0.00308	0	7	24									
VWF	7450	broad.mit.edu	37	12	6143929	6143929	+	Silent	SNP	G	G	A	rs141982646	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:6143929G>A	uc001qnn.1	-	20	2860	c.2610C>T	c.(2608-2610)ATC>ATT	p.I870I	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	870	VWFD 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGGCCATGCCGATCGTGGAGC	0.587		NaN											0	0	0	0.010504	0	19	74									
IFFO1	25900	broad.mit.edu	37	12	6664602	6664602	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:6664602C>T	uc001qpd.1	-	1	628	c.594G>A	c.(592-594)TCG>TCA	p.S198S	IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Silent_p.S198S|IFFO1_uc001qpf.1_Silent_p.S198S|IFFO1_uc001qpc.1_Silent_p.S198S	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	198						intermediate filament					0						CGTGCGAGAACGACCAGATGG	0.612		NaN											0	0	0	0.014758	0	5	34									
ACRBP	84519	broad.mit.edu	37	12	6749264	6749264	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:6749264C>G	uc001qpu.1	-	8	1435	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	LPAR5_uc010sff.1_5'Flank|ACRBP_uc001qpt.1_5'Flank|ACRBP_uc010sfg.1_Missense_Mutation_p.E430Q	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	463						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CTAAGGAACTCAGTCTGGAGC	0.562		NaN											0	0	0	0.020292	0	12	65									
NANOG	79923	broad.mit.edu	37	12	7942264	7942264	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:7942264C>G	uc009zfy.1	+	1	270	c.54C>G	c.(52-54)GAC>GAG	p.D18E		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	18					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		AAGCATCCGACTGTAAAGAAT	0.453		NaN											0	0	0	0.016522	0	22	112									
A2ML1	144568	broad.mit.edu	37	12	8988223	8988223	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:8988223G>A	uc001quz.3	+	6	702	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	46						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGCAGTGGCTGAGGGCAAGAC	0.507		NaN											0	0	0	0.021523	0	23	74									
MANSC1	54682	broad.mit.edu	37	12	12483751	12483751	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:12483751C>G	uc001rai.1	-	4	764	c.506G>C	c.(505-507)AGA>ACA	p.R169T	MANSC1_uc010shm.1_Missense_Mutation_p.R103T|MANSC1_uc001raj.1_Missense_Mutation_p.R135T|MANSC1_uc009zht.1_Missense_Mutation_p.R88T	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	169	Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		AAGTGTGTCTCTCCATGAGAT	0.448		NaN											0	0	0	0.00499	0	16	100									
GSG1	83445	broad.mit.edu	37	12	13240941	13240941	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:13240941G>A	uc001rbn.2	-	5	707	c.534C>T	c.(532-534)TTC>TTT	p.F178F	GSG1_uc001rbj.2_Silent_p.F142F|GSG1_uc001rbk.2_Missense_Mutation_p.H184Y|GSG1_uc001rbl.2_Intron|GSG1_uc001rbm.2_Intron|GSG1_uc001rbo.2_Missense_Mutation_p.H220Y|GSG1_uc001rbp.2_Silent_p.F155F|GSG1_uc001rbq.1_Missense_Mutation_p.H220Y	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	165	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GGAAGCTGATGAATTGAAGTC	0.512		NaN											0	0	0	0.004656	0	22	141									
GRIN2B	2904	broad.mit.edu	37	12	13768066	13768066	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:13768066A>T	uc001rbt.2	-	7	1815	c.1636T>A	c.(1636-1638)TCA>ACA	p.S546T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	546	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCAGAAGGTGAGACAGTCCCA	0.498		NaN											0	0	0	0.015359	0	32	76									
ERP27	121506	broad.mit.edu	37	12	15073907	15073907	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:15073907C>A	uc001rco.2	-	4	430	c.409G>T	c.(409-411)GAG>TAG	p.E137*		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	137	Thioredoxin.					endoplasmic reticulum lumen				breast(1)	1						CTGTTGATCTCAATGAAACGG	0.438		NaN											1	0	0.000602214	0.014758	0.000762437	5	65									
SOX5	6660	broad.mit.edu	37	12	23893833	23893833	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:23893833G>T	uc001rfw.2	-	5	811	c.709C>A	c.(709-711)CAA>AAA	p.Q237K	SOX5_uc001rfx.2_Missense_Mutation_p.Q224K|SOX5_uc001rfy.2_Missense_Mutation_p.Q224K|SOX5_uc010siv.1_Missense_Mutation_p.Q224K|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.Q189K	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	237	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						AGCTCCATTTGCTGACGCTGT	0.498		NaN											1	0	0.00198382	0.001984	0.00250015	7	57									
TM7SF3	51768	broad.mit.edu	37	12	27148173	27148173	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:27148173G>A	uc010sjl.1	-	5	925	c.687C>T	c.(685-687)CTC>CTT	p.L229L		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	229						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					GATTTACCTTGAGAGCACTGG	0.468		NaN											0	0	0	0.008871	0	20	110									
C12orf35	55196	broad.mit.edu	37	12	32136973	32136973	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:32136973C>T	uc001rks.2	+	4	3498	c.3084C>T	c.(3082-3084)TCC>TCT	p.S1028S		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1028										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			TAGATGCATCCAGCAACTATA	0.433		NaN											0	0	0	0.009096	0	4	47									
MLL2	8085	broad.mit.edu	37	12	49446362	49446362	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:49446362C>A	uc001rta.3	-	9	1243	c.1243G>T	c.(1243-1245)GAA>TAA	p.E415*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	415	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGTTTGGCTTCACATTGCAGG	0.547		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	0.00448238	0.004482	0.00562335	8	25									
MLL2	8085	broad.mit.edu	37	12	49446375	49446375	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:49446375C>G	uc001rta.3	-	9	1230	c.1230G>C	c.(1228-1230)GGG>GGC	p.G410G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	410	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATTGCAGGGGCCCTGGTTCCT	0.547		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.008291	0	10	25									
ESPL1	9700	broad.mit.edu	37	12	53679861	53679861	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:53679861A>T	uc001sck.2	+	18	3432	c.3341A>T	c.(3340-3342)AAG>ATG	p.K1114M	ESPL1_uc001scj.2_Missense_Mutation_p.K789M|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1114					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						ACTGTGGCCAAGGAGCCTGGC	0.602		NaN											0	0	0	0.005524	0	39	139									
TARBP2	6895	broad.mit.edu	37	12	53899548	53899548	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:53899548C>G	uc001sdo.2	+	8	1345	c.857C>G	c.(856-858)TCC>TGC	p.S286C	TARBP2_uc001sdp.2_Missense_Mutation_p.S265C|TARBP2_uc001sdq.2_Missense_Mutation_p.S142C|TARBP2_uc001sdr.2_Missense_Mutation_p.S142C|TARBP2_uc001sds.2_Silent_p.L243L|TARBP2_uc001sdt.2_Missense_Mutation_p.S265C|TARBP2_uc001sdu.2_Missense_Mutation_p.S142C|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	286	Sufficient for interaction with DICER1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						TCCCTGGGCTCCCTGGGTGCC	0.597		NaN											0	0	0	0.019004	0	34	123									
OR6C76	390326	broad.mit.edu	37	12	55820354	55820354	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:55820354C>T	uc010spm.1	+	1	317	c.317C>T	c.(316-318)TCA>TTA	p.S106L		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCCTTGGCTCAACGGAGTTT	0.403		NaN											0	0	0	0.016723	0	14	47									
DYRK2	8445	broad.mit.edu	37	12	68052281	68052281	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:68052281C>T	uc001str.3	+	3	1996	c.1594C>T	c.(1594-1596)CAC>TAC	p.H532Y	DYRK2_uc001sts.3_Missense_Mutation_p.H459Y	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	532	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		GGCTTTGCGGCACCCCTGGCT	0.547		NaN											0	0	0	0.004007	0	16	447									
ZFC3H1	196441	broad.mit.edu	37	12	72014016	72014016	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:72014016C>G	uc001swo.2	-	25	5183	c.4824G>C	c.(4822-4824)ATG>ATC	p.M1608I		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1608	TPR 3.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCAGAGCAATCATGTTTGTGT	0.403		NaN											0	0	0	0.021523	0	23	364									
EEA1	8411	broad.mit.edu	37	12	93174109	93174109	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:93174109C>G	uc001tck.2	-	24	3680	c.3415G>C	c.(3415-3417)GAA>CAA	p.E1139Q		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	1139	Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TTAGTGATTTCTTTTTCTTGT	0.308		NaN											0	0	0	0.001168	0	5	20									
STAB2	55576	broad.mit.edu	37	12	104096936	104096936	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:104096936A>G	uc001tjw.2	+	35	3911	c.3725A>G	c.(3724-3726)AAT>AGT	p.N1242S		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1242	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CTCTATGTAAATGAGGCTCCA	0.373		NaN											0	0	0	0.008871	0	20	48									
C12orf45	121053	broad.mit.edu	37	12	105388290	105388290	+	Nonsense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:105388290C>G	uc001tlb.2	+	4	407	c.374C>G	c.(373-375)TCA>TGA	p.S125*		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	125											0						CAGTCGGATTCAAAAGAAGTG	0.294		NaN											0	0	0	0.012319	0	22	30									
ANKRD13A	88455	broad.mit.edu	37	12	110456242	110456242	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:110456242G>C	uc001tpx.2	+	5	752	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc009zvm.1_Missense_Mutation_p.E165Q|ANKRD13A_uc010sxw.1_Missense_Mutation_p.E165Q	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	165											0						GCTGGGATTTGAAAACATGAG	0.443		NaN											0	0	0	0.013537	0	11	69									
RPH3A	22895	broad.mit.edu	37	12	113314469	113314469	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:113314469G>A	uc010syl.1	+	13	1331	c.969G>A	c.(967-969)GGG>GGA	p.G323G	RPH3A_uc001ttz.2_Silent_p.G323G|RPH3A_uc001tty.2_Silent_p.G319G|RPH3A_uc009zwe.1_Silent_p.G319G|RPH3A_uc010sym.1_Silent_p.G274G|RPH3A_uc001tua.2_Silent_p.G83G	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	323	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCGACCCTGGGACCACTGCCC	0.527		NaN											0	0	0	0.00308	0	7	17									
DDX54	79039	broad.mit.edu	37	12	113600964	113600964	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:113600964C>T	uc001tup.2	-	16	2082	c.2054G>A	c.(2053-2055)CGG>CAG	p.R685Q	DDX54_uc001tuq.3_Missense_Mutation_p.R685Q	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	685					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GTCCTTGGGCCGGTAGGGGAT	0.662		NaN											0	0	0	0.009718	0	42	20									
RPLP0	6175	broad.mit.edu	37	12	120635157	120635157	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:120635157C>G	uc001txp.2	-	7	997	c.760G>C	c.(760-762)GAG>CAG	p.E254Q	GCN1L1_uc001txo.2_5'Flank|RPLP0_uc001txq.2_Missense_Mutation_p.E254Q|RPLP0_uc001txr.2_Missense_Mutation_p.E192Q	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	254					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAATCCGTCTCCACAGACAAG	0.507		NaN											0	0	0	0.014323	0	21	105									
HPD	3242	broad.mit.edu	37	12	122286936	122286936	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:122286936G>T	uc001ubj.2	-	9	605	c.565C>A	c.(565-567)CCT>ACT	p.P189T	HPD_uc001ubk.2_Missense_Mutation_p.P150T	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	189					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TCCTGATCAGGCTGGTTTCCC	0.602		NaN											1	0	2.68362e-12	0.013537	3.66069e-12	12	89									
HIP1R	9026	broad.mit.edu	37	12	123343743	123343743	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:123343743A>T	uc001udj.1	+	22	2353	c.2294A>T	c.(2293-2295)CAG>CTG	p.Q765L	HIP1R_uc001udk.1_Missense_Mutation_p.Q30L	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	765					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CAGCTGGGCCAGGTGAGGCAC	0.652		NaN											0	0	0	0.014758	0	4	6									
PITPNM2	57605	broad.mit.edu	37	12	123494488	123494488	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:123494488G>A	uc001uej.1	-	5	691	c.552C>T	c.(550-552)GTC>GTT	p.V184V	PITPNM2_uc001uek.1_Silent_p.V184V|PITPNM2_uc009zxu.1_Silent_p.V184V	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	184					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGATGGGGAAGACCTGCTTCT	0.562		NaN											0	0	0	0.01441	0	55	190									
CHFR	55743	broad.mit.edu	37	12	133428240	133428241	+	Missense_Mutation	DNP	CC	CC	GT			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:133428240_133428241CC>GT	uc001ulf.2	-	12	1575_1576	c.1491_1492GG>AC	c.(1489-1494)GCGGAG>GCACAG	p.E498Q	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.E486Q|CHFR_uc010tbs.1_Missense_Mutation_p.E497Q|CHFR_uc001uld.2_Missense_Mutation_p.E457Q|CHFR_uc010tbt.1_Missense_Mutation_p.E406Q	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	498					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TGCTCGCGCTCCGCTCTCCGGT	0.644		NaN											0	0	0	0.004672	0	38	181									
SACS	26278	broad.mit.edu	37	13	23907016	23907016	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:23907016G>A	uc001uon.2	-	10	11588	c.10999C>T	c.(10999-11001)CAT>TAT	p.H3667Y	SACS_uc001uoo.2_Missense_Mutation_p.H3520Y|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3667					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TATTGAGGATGAAATCTAATG	0.383		NaN											0	0	0	0.001168	0	6	27									
SACS	26278	broad.mit.edu	37	13	23914840	23914840	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:23914840C>G	uc001uon.2	-	10	3764	c.3175G>C	c.(3175-3177)GAA>CAA	p.E1059Q	SACS_uc001uoo.2_Missense_Mutation_p.E912Q|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1059					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTTAGTACTTCTATATCAGGG	0.383		NaN											0	0	0	0.016522	0	25	102									
FAM123A	219287	broad.mit.edu	37	13	25744587	25744587	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:25744587C>G	uc001uqb.2	-	1	1271	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	FAM123A_uc001uqa.2_Missense_Mutation_p.E272Q|FAM123A_uc001uqc.2_Missense_Mutation_p.E272Q	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	391										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGACCTGCCTCTTCCTCTTGG	0.532		NaN											0	0	0	0.012319	0	21	103									
GPR12	2835	broad.mit.edu	37	13	27333290	27333290	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:27333290C>A	uc010aal.2	-	2	897	c.675G>T	c.(673-675)ATG>ATT	p.M225I	GPR12_uc010tdl.1_Missense_Mutation_p.M66I	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	225	Cytoplasmic (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		GGGCGTGCCTCATCACAATCT	0.567		NaN											1	0	1.06647e-15	0.017118	1.47173e-15	37	36									
NBEA	26960	broad.mit.edu	37	13	35926317	35926317	+	Silent	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:35926317T>C	uc001uvb.2	+	38	6242	c.6036T>C	c.(6034-6036)GCT>GCC	p.A2012A	NBEA_uc010abi.2_Silent_p.A668A	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2012						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AATATGCTGCTGATAGAAGAG	0.328		NaN											0	0	0	0.014758	0	5	5									
DCLK1	9201	broad.mit.edu	37	13	36428670	36428670	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:36428670G>A	uc001uvf.2	-	6	1234	c.1001C>T	c.(1000-1002)TCA>TTA	p.S334L	DCLK1_uc001uve.3_Missense_Mutation_p.S27L|DCLK1_uc010teh.1_Missense_Mutation_p.S27L|DCLK1_uc010abk.2_Missense_Mutation_p.S27L|DCLK1_uc001uvh.3_RNA	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	334	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCTGGTGGGTGATGGGCTTGG	0.527		NaN											0	0	0	0.017118	0	33	75									
SPERT	220082	broad.mit.edu	37	13	46287727	46287727	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:46287727C>G	uc001van.1	+	3	647	c.567C>G	c.(565-567)CTC>CTG	p.L189L	SPERT_uc001vao.2_Silent_p.L153L	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	189	Potential.					cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ACCGGATGCTCAGCAAGGAGA	0.617		NaN											0	0	0	0.020292	0	13	74									
FNDC3A	22862	broad.mit.edu	37	13	49710722	49710722	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:49710722G>A	uc001vcm.2	+	6	1050	c.745G>A	c.(745-747)GAT>AAT	p.D249N	FNDC3A_uc001vcl.1_Missense_Mutation_p.D249N|FNDC3A_uc001vcn.2_Missense_Mutation_p.D249N|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.D193N|FNDC3A_uc001vcq.2_Missense_Mutation_p.D193N	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	249						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACACAAGTTGATACAGAAAT	0.353		NaN											0	0	0	0.001168	0	6	51									
RNASEH2B	79621	broad.mit.edu	37	13	51528086	51528086	+	Missense_Mutation	SNP	A	A	G	rs150363383	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:51528086A>G	uc001vfa.3	+	10	1108	c.787A>G	c.(787-789)ACT>GCT	p.T263A	RNASEH2B_uc001vfb.3_Intron	NM_024570	NP_078846	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B isoform 1	263					RNA catabolic process	nucleus|ribonuclease H2 complex					0		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		AGAAGATTACACTAAGTTTAA	0.368		NaN											0	0	0	0.016723	0	12	8									
LECT1	11061	broad.mit.edu	37	13	53286974	53286974	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:53286974C>G	uc001vhf.2	-	5	610	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	LECT1_uc001vhg.2_Missense_Mutation_p.E167Q|LECT1_uc001vhh.2_Missense_Mutation_p.E156Q	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	167	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		AGAGAATTTTCTTCATATTTG	0.403		NaN											0	0	0	0.01892	0	23	51									
C13orf34	79866	broad.mit.edu	37	13	73321010	73321010	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:73321010G>C	uc001viv.1	+	10	1362	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	C13orf34_uc010thq.1_Missense_Mutation_p.E190Q|C13orf34_uc010aen.1_Missense_Mutation_p.E490Q|C13orf34_uc010thr.1_Missense_Mutation_p.E345Q|C13orf34_uc001viw.1_Missense_Mutation_p.E364Q	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	415					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		CAGTGCTTCTGAGAAAGAATT	0.423		NaN											0	0	0	0.010729	0	12	36									
DIS3	22894	broad.mit.edu	37	13	73334745	73334745	+	Silent	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:73334745A>G	uc001vix.3	-	20	3089	c.2715T>C	c.(2713-2715)GAT>GAC	p.D905D	DIS3_uc001viy.3_Silent_p.D875D|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	905					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CTTTAACTTTATCAAATACAT	0.328		NaN								Multiple Myeloma(4;0.011)			0	0	0	0.004482	0	9	36									
TBC1D4	9882	broad.mit.edu	37	13	75900527	75900527	+	Silent	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:75900527T>A	uc001vjl.1	-	10	2186	c.1839A>T	c.(1837-1839)ACA>ACT	p.T613T	TBC1D4_uc010aer.2_Silent_p.T613T|TBC1D4_uc010aes.2_Silent_p.T613T	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	613						cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		ACGCTGGCGGTGTCCCTGGTG	0.587		NaN											0	0	0	0.006214	0	8	64									
STK24	8428	broad.mit.edu	37	13	99114063	99114063	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:99114063C>G	uc001vnm.1	-	8	1289	c.1054G>C	c.(1054-1056)GGA>CGA	p.G352R	STK24_uc001vnn.1_Missense_Mutation_p.G340R|STK24_uc010tim.1_Missense_Mutation_p.G321R	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	352					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGAAGAGCTCCATTCTCGAGA	0.512		NaN											0	0	0	0.01441	0	42	208									
MYO16	23026	broad.mit.edu	37	13	109562401	109562401	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:109562401C>G	uc001vqt.1	+	16	1888	c.1762C>G	c.(1762-1764)CTT>GTT	p.L588V	MYO16_uc010agk.1_Missense_Mutation_p.L610V|MYO16_uc001vqu.1_Missense_Mutation_p.L388V|MYO16_uc010tjh.1_Missense_Mutation_p.L100V	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	588	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCACAACCTCTTGGCCAGAG	0.358		NaN											0	0	0	0.004007	0	17	80									
TUBGCP3	10426	broad.mit.edu	37	13	113208461	113208461	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:113208461G>C	uc001vse.1	-	8	1063	c.876C>G	c.(874-876)GTC>GTG	p.V292V	TUBGCP3_uc010tjq.1_Silent_p.V282V|TUBGCP3_uc001vsf.2_Silent_p.V292V|TUBGCP3_uc001vsg.1_Silent_p.V292V	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	292					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CAGAAAGCCTGACTGCTGTGT	0.403		NaN											0	0	0	0.004007	0	16	75									
NEDD8	4738	broad.mit.edu	37	14	24687356	24687356	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:24687356G>A	uc001wnn.2	-	3	235	c.132C>T	c.(130-132)ATC>ATT	p.I44I	CHMP4A_uc001wnj.2_5'Flank|MDP1_uc001wnk.1_5'Flank|CHMP4A_uc001wnm.1_5'Flank|MDP1_uc001wnl.1_5'Flank|NEDD8_uc001wno.2_RNA	NM_006156	NP_006147	Q15843	NEDD8_HUMAN	neural precursor cell expressed, developmentally	44		Interaction with UBE1C.			anatomical structure morphogenesis|protein neddylation|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin protein ligase binding				0				GBM - Glioblastoma multiforme(265;0.0186)		TGCCACTGTAGATGAGCCTCT	0.512		NaN											0	0	0	0.01441	0	47	83									
CTSG	1511	broad.mit.edu	37	14	25045381	25045381	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:25045381C>A	uc001wpq.2	-	1	86	c.49G>T	c.(49-51)GAG>TAG	p.E17*		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	17					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TCACCTGCCTCAGCCCCAGTG	0.438		NaN											1	0	0.00116845	0.001168	0.00147706	5	10									
C14orf106	55320	broad.mit.edu	37	14	45679581	45679581	+	Splice_Site	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:45679581A>C	uc001wwf.2	-	14	3611	c.3152_splice	c.e14+1	p.R1051_splice		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106						cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						ATGAATATTTACCTATTTATA	0.378		NaN											0	0	0	0.008291	0	9	27									
CDKL1	8814	broad.mit.edu	37	14	50845115	50845115	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:50845115G>C	uc010anu.1	-	9	1134	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					cagccgtcttgaaggggctgg	0		NaN											0	0	0	0.006214	0	10	31									
PTGER2	5732	broad.mit.edu	37	14	52781368	52781368	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:52781368C>T	uc001wzr.2	+	1	353	c.102C>T	c.(100-102)GCC>GCT	p.A34A		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	34	Helical; Name=1; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGTTCTCGGCCGGGGTGCTGG	0.682		NaN											0	0	0	0.010504	0	20	19									
RTN1	6252	broad.mit.edu	37	14	60193667	60193667	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:60193667G>C	uc001xen.1	-	3	1944	c.1735C>G	c.(1735-1737)CCC>GCC	p.P579A	RTN1_uc001xem.1_Missense_Mutation_p.P159A	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	579					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		AGCAGTGGGGGCGGGGCGCCA	0.582		NaN											0	0	0	0.001984	0	6	22									
PPM1A	5494	broad.mit.edu	37	14	60749714	60749714	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:60749714A>G	uc010apn.2	+	3	695	c.293A>G	c.(292-294)AAG>AGG	p.K98R	PPM1A_uc001xew.3_Missense_Mutation_p.K171R|PPM1A_uc001xex.3_Missense_Mutation_p.K98R|PPM1A_uc001xey.3_Missense_Mutation_p.K98R	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	98					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		GAAAATGTAAAGAATGGAATC	0.418		NaN											0	0	0	0.004656	0	27	68									
SYNE2	23224	broad.mit.edu	37	14	64497985	64497985	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:64497985C>G	uc001xgm.2	+	45	7361	c.7131C>G	c.(7129-7131)GGC>GGG	p.G2377G	SYNE2_uc001xgl.2_Silent_p.G2377G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2377	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTCTGCCAGGCAGAGAGAAGC	0.453		NaN											0	0	0	0.021523	0	25	76									
PTPN21	11099	broad.mit.edu	37	14	88936060	88936060	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:88936060C>A	uc001xwv.3	-	17	3349	c.3018G>T	c.(3016-3018)AAG>AAT	p.K1006N	PTPN21_uc010twc.1_Missense_Mutation_p.K802N	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1006	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						ACCTAAAGCTCTTCTCCCTTC	0.502		NaN											1	0	9.70103e-10	0.008291	1.30609e-09	9	20									
EML5	161436	broad.mit.edu	37	14	89109329	89109329	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:89109329C>G	uc001xxg.2	-	31	4331	c.4145G>C	c.(4144-4146)AGA>ACA	p.R1382T	EML5_uc001xxf.2_Missense_Mutation_p.R169T|EML5_uc001xxh.1_Missense_Mutation_p.R513T	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1374						cytoplasm|microtubule				ovary(3)	3						CCTACAGTCTCTGCCTCGATA	0.338		NaN											0	0	0	0.00499	0	16	45									
BTBD7	55727	broad.mit.edu	37	14	93717986	93717986	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:93717986C>T	uc001ybo.2	-	8	2091	c.1765G>A	c.(1765-1767)GAG>AAG	p.E589K	BTBD7_uc010aur.2_Missense_Mutation_p.E114K|BTBD7_uc010two.1_Missense_Mutation_p.E409K|BTBD7_uc001ybp.2_Missense_Mutation_p.E238K	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	589										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACCATCATCTCATCTAGCACT	0.403		NaN											0	0	0	0.01441	0	49	37									
DYNC1H1	1778	broad.mit.edu	37	14	102510695	102510695	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:102510695G>C	uc001yks.2	+	71	12933	c.12769G>C	c.(12769-12771)GAC>CAC	p.D4257H		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4257					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CGGGCGCGTGGACAACGAGTT	0.557		NaN											0	0	0	0.013537	0	10	18									
EIF2AK4	440275	broad.mit.edu	37	15	40301819	40301819	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:40301819G>C	uc001zkm.1	+	26	3631	c.3581G>C	c.(3580-3582)AGA>ACA	p.R1194T	EIF2AK4_uc010bbj.1_Missense_Mutation_p.R895T|EIF2AK4_uc001zkn.1_Missense_Mutation_p.R294T|EIF2AK4_uc001zko.1_Missense_Mutation_p.R132T|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1194	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCCCAGGAAAGAAATTACAGT	0.333		NaN											0	0	0	0.004482	0	9	28									
ITPKA	3706	broad.mit.edu	37	15	41794660	41794660	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:41794660C>T	uc001znz.2	+	5	1080	c.1069C>T	c.(1069-1071)CGC>TGC	p.R357C		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	357					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCAGGTGCTTCGCGTCTTTGA	0.622		NaN											0	0	0	0.017118	0	33	67									
SLC24A5	283652	broad.mit.edu	37	15	48434351	48434351	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:48434351A>G	uc001zwe.2	+	9	1379	c.1306A>G	c.(1306-1308)AGA>GGA	p.R436G	SLC24A5_uc010bel.2_Missense_Mutation_p.R376G|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Missense_Mutation_p.R67G	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	436	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		AGTAAACAGCAGAGGACTAAC	0.363		NaN											0	0	0	0.003163	0	16	37									
USP8	9101	broad.mit.edu	37	15	50784944	50784944	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:50784944C>G	uc001zym.3	+	16	2781	c.2281C>G	c.(2281-2283)CAG>GAG	p.Q761E	USP8_uc001zyl.3_Missense_Mutation_p.Q761E|USP8_uc001zyn.3_Missense_Mutation_p.Q761E|USP8_uc010ufh.1_Missense_Mutation_p.Q655E|uc001zyo.1_RNA|USP8_uc001zyp.3_5'Flank	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	761					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TTCTGCTTCTCAGATTCGGAA	0.388		NaN											0	0	0	0.012319	0	19	65									
WDR72	256764	broad.mit.edu	37	15	54008834	54008834	+	Silent	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:54008834A>T	uc002acj.2	-	4	351	c.309T>A	c.(307-309)GCT>GCA	p.A103A	WDR72_uc010bfi.1_Silent_p.A103A	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	103										lung(1)|skin(1)	2				all cancers(107;0.0511)		AAGGAAGTGTAGCCTTCTCCA	0.428		NaN											0	0	0	0.008291	0	9	25									
GCOM1	145781	broad.mit.edu	37	15	57921940	57921940	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:57921940A>T	uc002aei.2	+	6	685	c.566A>T	c.(565-567)AAG>ATG	p.K189M	GCOM1_uc002aej.2_Missense_Mutation_p.K189M|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Missense_Mutation_p.K189M|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Missense_Mutation_p.K189M|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	189	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AGCAACATTAAGGATCAAATC	0.458		NaN											0	0	0	0.016723	0	13	34									
VPS13C	54832	broad.mit.edu	37	15	62219320	62219320	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:62219320G>C	uc002agz.2	-	52	6560	c.6486C>G	c.(6484-6486)CTC>CTG	p.L2162L	VPS13C_uc002aha.2_Silent_p.L2119L|VPS13C_uc002ahb.1_Silent_p.L2162L|VPS13C_uc002ahc.1_Silent_p.L2119L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2162					protein localization					ovary(2)	2						TCTTTTCTCTGAGAAAAGGGC	0.393		NaN											0	0	0	0.017118	0	34	71									
MPI	4351	broad.mit.edu	37	15	75183880	75183880	+	Missense_Mutation	SNP	C	C	T	rs104894494		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:75183880C>T	uc002azc.1	+	3	310	c.305C>T	c.(304-306)TCA>TTA	p.S102L	MPI_uc010ulv.1_Missense_Mutation_p.S102L|MPI_uc010ulw.1_Missense_Mutation_p.S52L|MPI_uc002azd.1_Missense_Mutation_p.S102L|MPI_uc010ulx.1_Missense_Mutation_p.S52L|MPI_uc002aze.1_Missense_Mutation_p.S102L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	102			S -> L (in CDG1B).		dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						AAAGTGCTCTCAGTTGAAACA	0.532		NaN											0	0	0	0.01441	0	44	107									
WFIKKN1	117166	broad.mit.edu	37	16	683267	683267	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:683267C>T	uc002cht.1	+	2	1099	c.857C>T	c.(856-858)GCC>GTC	p.A286V	WFIKKN1_uc002chs.1_3'UTR	NM_053284	NP_444514	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz	286						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity				0		Hepatocellular(780;0.00335)				CGAGAGCCGGCCAGGGACGCA	0.716		NaN											0	0	0	0.009096	0	4	10									
NUBP2	10101	broad.mit.edu	37	16	1836612	1836612	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:1836612A>G	uc002cmw.3	+	2	180	c.91A>G	c.(91-93)ATC>GTC	p.I31V	NUBP2_uc002cmx.3_5'UTR|NUBP2_uc010brx.2_5'UTR	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	31						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0						GAAAAGCACCATCTCCACGGA	0.662		NaN											0	0	0	0.016723	0	13	85									
TSC2	7249	broad.mit.edu	37	16	2110796	2110796	+	Silent	SNP	G	G	A	rs45517149		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:2110796G>A	uc002con.2	+	11	1207	c.1101G>A	c.(1099-1101)CGG>CGA	p.R367R	TSC2_uc010bsd.2_Silent_p.R367R|TSC2_uc002coo.2_Silent_p.R367R|TSC2_uc010uvv.1_Silent_p.R330R|TSC2_uc010uvw.1_Silent_p.R318R|TSC2_uc002cop.2_Silent_p.R167R	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	367	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				TCATCGAACGGCTCCTTCAGC	0.602		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.014323	0	24	35									
PRSS21	10942	broad.mit.edu	37	16	2868796	2868796	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:2868796C>T	uc002crt.2	+	4	482	c.376C>T	c.(376-378)CTG>TTG	p.L126L	PRSS21_uc002crs.2_Silent_p.L124L|PRSS21_uc002crr.2_Silent_p.L126L	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	126	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						GAATATCTATCTGAGCCCTCG	0.537		NaN											0	0	0	0.005443	0	26	116									
BTBD12	84464	broad.mit.edu	37	16	3641148	3641148	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:3641148C>A	uc002cvp.2	-	12	3118	c.2491G>T	c.(2491-2493)GAG>TAG	p.E831*		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	831	Potential.|Interaction with PLK1 and TERF2-TERF2IP.|Glu-rich.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						AACAAAGTCTCCGCTTCCTCC	0.453		NaN						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				1	0	2.94884e-30	0.01441	4.17374e-30	69	101									
VASN	114990	broad.mit.edu	37	16	4431070	4431070	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:4431070C>T	uc002cwj.1	+	2	347	c.192C>T	c.(190-192)ATC>ATT	p.I64I	CORO7_uc002cwe.2_Intron|CORO7_uc002cwf.2_Intron|CORO7_uc002cwg.3_Intron|CORO7_uc002cwh.3_Intron|CORO7_uc010uxh.1_Intron|CORO7_uc010uxi.1_Intron|CORO7_uc002cwi.1_Intron|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_Intron	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	slit-like 2 precursor	64	Extracellular (Potential).|LRR 1.					extracellular region|integral to membrane					0						AGAACGGCATCACCATGCTCG	0.672		NaN											0	0	0	0.00308	0	7	13									
NAGPA	51172	broad.mit.edu	37	16	5075523	5075523	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:5075523C>T	uc002cyg.2	-	10	1525	c.1504G>A	c.(1504-1506)GAG>AAG	p.E502K	NAGPA_uc010buc.2_Missense_Mutation_p.E199K|NAGPA_uc002cyf.2_Missense_Mutation_p.E220K|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_3'UTR	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	502	Cytoplasmic (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	TGCTCCTTCTCTGCGGCCAGA	0.647		NaN											0	0	0	0.01441	0	58	238									
C16orf75	116028	broad.mit.edu	37	16	11444614	11444614	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:11444614G>A	uc002daw.1	+	2	429	c.411G>A	c.(409-411)CTG>CTA	p.L137L	C16orf75_uc002daq.1_RNA	NM_152308	NP_689521	Q96E14	RMI2_HUMAN	RecQ-mediated genome instability protein 2	137					DNA replication	nucleus	DNA binding				0						TGTGGGAACTGGAGGTAGAAG	0.438		NaN	T	CIITA	PMBL|Hodgkin Lymphona|								0	0	0	0.010504	0	19	108									
ITPRIPL2	162073	broad.mit.edu	37	16	19126901	19126901	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:19126901T>A	uc002dfu.3	+	1	1648	c.1118T>A	c.(1117-1119)CTC>CAC	p.L373H	ITPRIPL2_uc002dft.2_Missense_Mutation_p.L69H	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	373	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GCCTGCTACCTCAAGTGCCTG	0.647		NaN											0	0	0	0.013726	0	34	146									
DNAH3	55567	broad.mit.edu	37	16	21073952	21073952	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:21073952C>T	uc010vbe.1	-	25	3571	c.3571G>A	c.(3571-3573)GAC>AAC	p.D1191N		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1191	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGGAGAGGGTCCTTTGTCTCG	0.448		NaN											0	0	0	0.004007	0	17	47									
JMJD5	79831	broad.mit.edu	37	16	27221612	27221612	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:27221612C>T	uc002doh.2	+	2	350	c.168C>T	c.(166-168)TTC>TTT	p.F56F	JMJD5_uc010bxv.2_Silent_p.F56F|JMJD5_uc010vcn.1_Silent_p.F94F|JMJD5_uc010bxw.2_Silent_p.F56F	NM_024773	NP_079049	Q8N371	KDM8_HUMAN	jumonji domain containing 5 isoform 2	56					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(2)|upper_aerodigestive_tract(1)	3						CTGAGCTCTTCTACGAGGGCA	0.587		NaN											0	0	0	0.013537	0	12	55									
SRCAP	10847	broad.mit.edu	37	16	30750254	30750254	+	Missense_Mutation	SNP	C	C	T	rs141497857		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:30750254C>T	uc002dze.1	+	34	9278	c.8893C>T	c.(8893-8895)CGG>TGG	p.R2965W	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2760W	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2965	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTCCGAAAGTCGGACACAGCC	0.572		NaN											0	0	0	0.014323	0	22	111									
RNF40	9810	broad.mit.edu	37	16	30780185	30780185	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:30780185G>A	uc002dzq.2	+	15	2247	c.2124G>A	c.(2122-2124)CGG>CGA	p.R708R	RNF40_uc010caa.2_Silent_p.R708R|RNF40_uc010cab.2_Silent_p.R608R|RNF40_uc010vfa.1_Silent_p.R40R|RNF40_uc002dzr.2_Silent_p.R708R|RNF40_uc010vfb.1_Silent_p.R400R|RNF40_uc010vfc.1_Silent_p.R40R	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	708	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GCCGCATCCGGGAATTGGAGG	0.562		NaN											0	0	0	0.01441	0	58	147									
C16orf78	123970	broad.mit.edu	37	16	49433094	49433094	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:49433094G>A	uc002efr.2	+	5	746	c.703G>A	c.(703-705)GAT>AAT	p.D235N		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	235										central_nervous_system(1)	1						GTTGTGCAAGGATGCAGGAAT	0.478		NaN											0	0	0	0.016522	0	23	101									
GNAO1	2775	broad.mit.edu	37	16	56362664	56362664	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:56362664A>G	uc002eit.3	+	4	1322	c.425A>G	c.(424-426)AAC>AGC	p.N142S	GNAO1_uc002eiu.3_Missense_Mutation_p.N142S	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	142					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				GAGTGCTTCAACCGGTCCCGG	0.602		NaN											0	0	0	0.005443	0	27	74									
AMFR	267	broad.mit.edu	37	16	56423172	56423172	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:56423172C>T	uc002eiy.2	-	9	1406	c.1201G>A	c.(1201-1203)GAG>AAG	p.E401K	AMFR_uc002eix.2_Intron	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	401					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						ACCAAATTCTCATCCAAGTTC	0.448		NaN											0	0	0	0.00499	0	16	113									
GPR97	222487	broad.mit.edu	37	16	57712121	57712121	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:57712121G>C	uc002emh.2	+	4	488	c.385G>C	c.(385-387)GAC>CAC	p.D129H	GPR97_uc010cdc.2_Missense_Mutation_p.D129H|GPR97_uc010vhv.1_Missense_Mutation_p.D9H|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_5'Flank	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	129	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CAAGCCCCCTGACAGAGTGCG	0.587		NaN											0	0	0	0.00632	0	26	153									
CNGB1	1258	broad.mit.edu	37	16	57935315	57935315	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:57935315C>T	uc002emt.2	-	29	2982	c.2917G>A	c.(2917-2919)GAC>AAC	p.D973N	CNGB1_uc010cdh.2_Missense_Mutation_p.D967N	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	973	Helical; Name=H6; (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						TTCAGCATGTCAAAGATCATC	0.572		NaN											0	0	0	0.01441	0	67	197									
GFOD2	81577	broad.mit.edu	37	16	67709852	67709852	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:67709852T>A	uc002eub.2	-	3	659	c.364A>T	c.(364-366)AAC>TAC	p.N122Y	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.N17Y	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	122						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		CGCAGCACGTTCCCTACCAGG	0.572		NaN											0	0	0	0.013537	0	11	86									
RANBP10	57610	broad.mit.edu	37	16	67768937	67768937	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:67768937G>C	uc002eud.2	-	6	716	c.600C>G	c.(598-600)CTC>CTG	p.L200L	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Silent_p.L144L|RANBP10_uc010vjv.1_Silent_p.L83L|RANBP10_uc010vjx.1_Silent_p.L200L|RANBP10_uc010vjy.1_Silent_p.L68L	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	200	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CGGTGGGGTAGAGGTTGGCCT	0.592		NaN											0	0	0	0.013537	0	12	81									
CDH1	999	broad.mit.edu	37	16	68835746	68835746	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:68835746A>G	uc002ewg.1	+	3	461	c.337A>G	c.(337-339)AAA>GAA	p.K113E	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.K113E	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	113					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GTTTTCCACCAAAGTCACGCT	0.502		NaN	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.007413	0	14	96									
ZNF23	7571	broad.mit.edu	37	16	71482035	71482035	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:71482035G>C	uc002faf.2	-	6	2707	c.1893C>G	c.(1891-1893)CTC>CTG	p.L631L	ZNF23_uc002fad.2_Silent_p.L573L|ZNF23_uc002fae.2_Silent_p.L573L|ZNF23_uc010vmf.1_Silent_p.L573L|ZNF23_uc002fag.2_Silent_p.L573L|ZNF23_uc002fah.2_Silent_p.L631L|ZNF23_uc002fai.2_Silent_p.L670L	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	631	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		GATGCTGACTGAGCTGGAAGC	0.383		NaN											0	0	0	0.006214	0	10	102									
ZFPM1	161882	broad.mit.edu	37	16	88598530	88598530	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:88598530C>T	uc002fkv.2	+	7	866	c.833C>T	c.(832-834)ACA>ATA	p.T278I		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	278					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GCAGCCGCCACAGACGAGAAG	0.687		NaN											0	0	0	0.01441	0	34	50									
FANCA	2175	broad.mit.edu	37	16	89813043	89813043	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:89813043G>A	uc002fou.1	-	35	3504	c.3462C>T	c.(3460-3462)TTC>TTT	p.F1154F	FANCA_uc010vpn.1_Silent_p.F1154F|FANCA_uc010vpo.1_Silent_p.F240F	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1154					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TGGCCAGTATGAAGTCGACCA	0.562		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.015359	0	30	92									
SLC25A11	8402	broad.mit.edu	37	17	4841336	4841336	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:4841336C>T	uc002fzo.1	-	7	884	c.771G>A	c.(769-771)CCG>CCA	p.P257P	SLC25A11_uc002fzp.1_Silent_p.P253P|RNF167_uc002fzq.2_5'Flank|RNF167_uc002fzr.2_5'Flank|RNF167_uc002fzs.2_5'Flank|RNF167_uc002fzt.2_5'Flank|RNF167_uc002fzu.2_5'Flank|RNF167_uc002fzv.2_5'Flank|RNF167_uc002fzw.1_5'Flank|RNF167_uc002fzx.2_5'Flank	NM_003562	NP_003553	Q02978	M2OM_HUMAN	solute carrier family 25 member 11 isoform 1	257	Solcar 3.				gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity				0						TCTTGTATTCCGGCTTCCCAT	0.627		NaN											0	0	0	0.021022	0	34	140									
ZNF232	7775	broad.mit.edu	37	17	5009199	5009199	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:5009199C>G	uc002gas.2	-	5	1928	c.1174G>C	c.(1174-1176)GAA>CAA	p.E392Q	ZNF232_uc002gar.1_Missense_Mutation_p.E410Q|ZNF232_uc002gat.2_Missense_Mutation_p.E419Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	392	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTCCCACATTCTTTACATATA	0.443		NaN											0	0	0	0.01441	0	86	49									
C1QBP	708	broad.mit.edu	37	17	5336678	5336678	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:5336678G>C	uc002gby.1	-	5	712	c.634C>G	c.(634-636)CAG>GAG	p.Q212E		NM_001212	NP_001203	Q07021	C1QBP_HUMAN	complement component 1, q subcomponent binding	212					blood coagulation, intrinsic pathway|immune response|interspecies interaction between organisms	mitochondrial matrix|nucleus|plasma membrane				ovary(1)	1						CCAGTGGACTGAAAGCTAACT	0.468		NaN											0	0	0	0.01441	0	48	132									
ACAP1	9744	broad.mit.edu	37	17	7250491	7250491	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:7250491G>A	uc002ggd.2	+	14	1479	c.1273G>A	c.(1273-1275)GAG>AAG	p.E425K		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	425	Arf-GAP.|C4-type.|Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						CGACTGCCGGGAGCCAGCCCC	0.657		NaN											0	0	0	0.01892	0	20	60									
MYH13	8735	broad.mit.edu	37	17	10216043	10216043	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10216043C>A	uc002gmk.1	-	31	4303	c.4213G>T	c.(4213-4215)GAG>TAG	p.E1405*		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1405	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTGTTCTCCTCTGCTTCCTGG	0.517		NaN											1	0	5.4927e-09	0.004482	7.35916e-09	7	22									
MYH13	8735	broad.mit.edu	37	17	10243492	10243492	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10243492C>G	uc002gmk.1	-	18	2121	c.2031G>C	c.(2029-2031)CTG>CTC	p.L677L		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	677	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CATTGGGAATCAGACATCGTA	0.428		NaN											0	0	0	0.010504	0	18	4									
MYH8	4626	broad.mit.edu	37	17	10309620	10309620	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10309620G>A	uc002gmm.2	-	20	2361	c.2266C>T	c.(2266-2268)CAT>TAT	p.H756Y	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	756	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TATTGAGTATGATCAATATCA	0.378		NaN							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				0	0	0	0.006214	0	10	15									
MYH1	4619	broad.mit.edu	37	17	10395785	10395785	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10395785T>G	uc002gmo.2	-	40	5862	c.5768A>C	c.(5767-5769)AAG>ACG	p.K1923T	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1923	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CACCCTCAGCTTGTTGACCTG	0.478		NaN											0	0	0	0.009535	0	29	72									
ATPAF2	91647	broad.mit.edu	37	17	17924527	17924527	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:17924527G>C	uc002gse.1	-	7	795	c.642C>G	c.(640-642)CTC>CTG	p.L214L	ATPAF2_uc002gsd.1_RNA|ATPAF2_uc002gsf.1_RNA	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	214					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)					CCATGGACTTGAGCTGGGCAG	0.592		NaN											0	0	0	0.013537	0	10	42									
MYO15A	51168	broad.mit.edu	37	17	18042859	18042859	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:18042859C>T	uc010vxh.1	+	18	5483	c.5145C>T	c.(5143-5145)TTC>TTT	p.F1715F		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1715	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGCACAAGTTCCTGGACAAGA	0.592		NaN											0	0	0	0.01441	0	47	25									
SLC47A2	146802	broad.mit.edu	37	17	19608794	19608794	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:19608794G>C	uc002gwe.3	-	10	1147	c.972C>G	c.(970-972)CTC>CTG	p.L324L	SLC47A2_uc002gwg.3_Silent_p.L288L|SLC47A2_uc002gwf.3_Silent_p.L288L|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA|SLC47A2_uc010cqt.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	324	Extracellular (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					CCTGGGCAGAGAGATCCACCA	0.647		NaN											0	0	0	0.014758	0	5	23									
ALDH3A1	218	broad.mit.edu	37	17	19646659	19646659	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:19646659G>A	uc010cqu.2	-	2	610	c.280C>T	c.(280-282)CAG>TAG	p.Q94*	ALDH3A1_uc010vzd.1_Nonsense_Mutation_p.Q94*|ALDH3A1_uc002gwj.2_Nonsense_Mutation_p.Q94*|ALDH3A1_uc010cqv.2_Nonsense_Mutation_p.Q94*|ALDH3A1_uc002gwk.2_Silent_p.L10L|ALDH3A1_uc002gwl.1_Nonsense_Mutation_p.Q21*	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	94					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TCGTCCTGCTGAGTCTGGGGC	0.602		NaN											0	0	0	0.021523	0	26	161									
SSH2	85464	broad.mit.edu	37	17	27998974	27998974	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27998974G>C	uc002heo.1	-	8	707	c.707C>G	c.(706-708)TCT>TGT	p.S236C	SSH2_uc010wbh.1_Missense_Mutation_p.S263C|SSH2_uc002hep.1_Missense_Mutation_p.S236C	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	236					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						GAGAGCTGGAGAGTCGGGCCG	0.448		NaN											0	0	0	0.00499	0	8	201									
SSH2	85464	broad.mit.edu	37	17	27998987	27998987	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27998987G>T	uc002heo.1	-	8	694	c.694C>A	c.(694-696)CAC>AAC	p.H232N	SSH2_uc010wbh.1_Missense_Mutation_p.H259N|SSH2_uc002hep.1_Missense_Mutation_p.H232N	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	232					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCGGGCCGGTGGGACTGTACA	0.448		NaN											1	0	1.87028e-06	0.012319	2.46985e-06	11	205									
SSH2	85464	broad.mit.edu	37	17	27999021	27999021	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27999021G>A	uc002heo.1	-	8	660	c.660C>T	c.(658-660)GTC>GTT	p.V220V	SSH2_uc010wbh.1_Silent_p.V247V|SSH2_uc002hep.1_Silent_p.V220V	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	220					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCCATTCATTGACTGAGGATT	0.468		NaN											0	0	0	0.013537	0	10	187									
SSH2	85464	broad.mit.edu	37	17	27999025	27999025	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27999025G>A	uc002heo.1	-	8	656	c.656C>T	c.(655-657)TCA>TTA	p.S219L	SSH2_uc010wbh.1_Missense_Mutation_p.S246L|SSH2_uc002hep.1_Missense_Mutation_p.S219L	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	219					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TTCATTGACTGAGGATTGATC	0.468		NaN											0	0	0	0.013537	0	10	194									
CDK5R1	8851	broad.mit.edu	37	17	30814982	30814982	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:30814982C>A	uc002hhn.2	+	2	565	c.344C>A	c.(343-345)TCG>TAG	p.S115*	CDK5R1_uc010wca.1_Nonsense_Mutation_p.S115*|CDK5R1_uc010ctc.2_5'UTR	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	115					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			AGCCAGCTCTCGGGTTCCCAG	0.672		NaN											1	0	4.75426e-39	0.01441	6.74062e-39	76	164									
TMEM132E	124842	broad.mit.edu	37	17	32954018	32954018	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:32954018T>G	uc002hif.2	+	3	998	c.670T>G	c.(670-672)TAT>GAT	p.Y224D		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	224	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CATCCTCCTCTATCTGGCCCC	0.632		NaN											0	0	0	0.014323	0	20	134									
DHRS11	79154	broad.mit.edu	37	17	34951498	34951498	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:34951498C>T	uc002hnd.2	+	2	459	c.245C>T	c.(244-246)TCA>TTA	p.S82L		NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	82						extracellular region	binding|oxidoreductase activity				0						TCCATGTTCTCAGCTATCCGT	0.542		NaN											0	0	0	0.01441	0	96	118									
ORMDL3	94103	broad.mit.edu	37	17	38080454	38080454	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:38080454C>T	uc002htj.1	-	2	143	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ORMDL3_uc002hti.1_RNA|ORMDL3_uc002htk.1_Missense_Mutation_p.M1I	NM_139280	NP_644809	Q8N138	ORML3_HUMAN	ORM1-like 3	1	Cytoplasmic (Potential).				ceramide metabolic process	integral to membrane|SPOTS complex	protein binding				0	Colorectal(19;0.000442)		Lung(15;0.0234)			TGCCCACATTCATCCTGCTGC	0.617		NaN											0	0	0	0.004007	0	15	119									
PSMD3	5709	broad.mit.edu	37	17	38151529	38151529	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:38151529G>A	uc002htn.1	+	8	1361	c.1197G>A	c.(1195-1197)CGG>CGA	p.R399R	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Silent_p.R300R	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	399	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					TCCGGCTGCGGCACAACGTGA	0.537		NaN											0	0	0	0.011902	0	42	259									
KRT12	3859	broad.mit.edu	37	17	39019991	39019991	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:39019991C>T	uc002hvk.2	-	4	957	c.933G>A	c.(931-933)CAG>CAA	p.Q311Q		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	311	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CCTTCCGATTCTGCTCAGCGA	0.547		NaN											0	0	0	0.01441	0	63	33									
KRT38	8687	broad.mit.edu	37	17	39594846	39594846	+	Missense_Mutation	SNP	T	T	G	rs143250758	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:39594846T>G	uc002hwq.1	-	5	1340	c.917A>C	c.(916-918)GAC>GCC	p.D306A		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	306	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GCAGGACATGTCCTGCAGGCT	0.632		NaN											0	0	0	0.014323	0	20	136									
KRT36	8689	broad.mit.edu	37	17	39645947	39645947	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:39645947G>C	uc002hwt.2	-	1	170	c.170C>G	c.(169-171)TCT>TGT	p.S57C		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	57	Head.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CCCAAGGCCAGAGAGGCCCGA	0.637		NaN											0	0	0	0.01441	0	104	53									
UBTF	7343	broad.mit.edu	37	17	42290269	42290269	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:42290269G>T	uc002igb.2	-	6	645	c.578C>A	c.(577-579)TCG>TAG	p.S193*	UBTF_uc002igc.2_Nonsense_Mutation_p.S193*|UBTF_uc010czs.2_Nonsense_Mutation_p.S193*|UBTF_uc002igd.2_Nonsense_Mutation_p.S193*|UBTF_uc010czt.2_Nonsense_Mutation_p.S193*|UBTF_uc002ige.2_Nonsense_Mutation_p.S193*	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	193					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TGGGATGTCCGATTTCTTGGC	0.587		NaN											1	0	1.3612e-06	0.003163	1.80044e-06	13	346									
NMT1	4836	broad.mit.edu	37	17	43138785	43138785	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:43138785T>C	uc002ihz.2	+	1	106	c.88T>C	c.(88-90)TGC>CGC	p.C30R	DCAKD_uc010dab.1_5'Flank|NMT1_uc010dac.1_RNA|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	30					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				CCATGAGCACTGCAGCGATTG	0.602		NaN											0	0	0	0.01441	0	58	16									
TMEM100	55273	broad.mit.edu	37	17	53798395	53798395	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:53798395G>A	uc002iuj.3	-	2	348	c.37C>T	c.(37-39)CCA>TCA	p.P13S	TMEM100_uc002iuk.3_Missense_Mutation_p.P13S	NM_018286	NP_060756	Q9NV29	TM100_HUMAN	transmembrane protein 100	13						integral to membrane					0						TGAGCCTTTGGGGCTCCCAGG	0.507		NaN											0	0	0	0.004656	0	25	159									
DDX42	11325	broad.mit.edu	37	17	61895172	61895172	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:61895172C>T	uc002jbu.2	+	19	2488	c.2231C>T	c.(2230-2232)TCA>TTA	p.S744L	DDX42_uc002jbv.2_Missense_Mutation_p.S744L|DDX42_uc002jbx.2_Missense_Mutation_p.S480L|DDX42_uc002jby.2_Missense_Mutation_p.S290L|DDX42_uc010wps.1_Missense_Mutation_p.S112L	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	744	Necessary for interaction with TP53BP2.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						CCAACTAACTCAGCACAACAG	0.542		NaN											0	0	0	0.01441	0	86	43									
GGA3	23163	broad.mit.edu	37	17	73242646	73242646	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:73242646G>T	uc002jni.1	-	3	154	c.145C>A	c.(145-147)CTG>ATG	p.L49M	GGA3_uc002jnj.1_Missense_Mutation_p.L49M|GGA3_uc010wrw.1_Translation_Start_Site|GGA3_uc002jnk.1_Translation_Start_Site|GGA3_uc010wrx.1_Intron|GGA3_uc010wry.1_Translation_Start_Site|GGA3_uc010wrz.1_Missense_Mutation_p.L49M	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	49	VHS.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGGGCCAGCAGTCGGACGGCG	0.637		NaN											1	0	6.94344e-10	0.006122	9.36347e-10	15	77									
APCDD1	147495	broad.mit.edu	37	18	10487667	10487667	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:10487667G>A	uc002kom.3	+	5	1531	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	393	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)		GTGCGGGGCCGAGGGCTCCTG	0.582		NaN											0	0	0	0.013726	0	32	84									
MYO5B	4645	broad.mit.edu	37	18	47369614	47369614	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:47369614C>T	uc002leb.2	-	34	4896	c.4608G>A	c.(4606-4608)CTG>CTA	p.L1536L	MYO5B_uc002ldz.2_Silent_p.L106L|MYO5B_uc002lea.2_Silent_p.L651L	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1536	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TGCTTACTTTCAGGACTTTCT	0.527		NaN											0	0	0	0.006214	0	9	30									
CDH7	1005	broad.mit.edu	37	18	63526247	63526247	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:63526247G>A	uc002ljz.2	+	9	1784	c.1459G>A	c.(1459-1461)GAG>AAG	p.E487K	CDH7_uc002lka.2_Missense_Mutation_p.E487K|CDH7_uc002lkb.2_Missense_Mutation_p.E487K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	487	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CATGGACTATGAGACCACCGT	0.428		NaN											0	0	0	0.014758	0	5	31									
ZNF407	55628	broad.mit.edu	37	18	72343704	72343704	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:72343704C>G	uc002llw.2	+	1	786	c.729C>G	c.(727-729)GTC>GTG	p.V243V	ZNF407_uc010xfc.1_Silent_p.V243V|ZNF407_uc010dqu.1_Silent_p.V243V|ZNF407_uc002llu.2_Silent_p.V242V	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CACAGAAGGTCTTTTCCTGTG	0.453		NaN											0	0	0	0.004656	0	27	93									
MED16	10025	broad.mit.edu	37	19	875330	875330	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:875330G>A	uc002lqd.1	-	10	1836	c.1685C>T	c.(1684-1686)TCG>TTG	p.S562L	MED16_uc010drw.1_Missense_Mutation_p.S387L|MED16_uc002lqe.2_Missense_Mutation_p.S551L|MED16_uc002lqf.2_Missense_Mutation_p.S551L|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Missense_Mutation_p.S482L|MED16_uc010xfx.1_Missense_Mutation_p.S407L|MED16_uc010xfy.1_Missense_Mutation_p.S139L|MED16_uc010xfz.1_5'Flank	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	562					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCAGCAGCGACTTCAGGGT	0.627		NaN											0	0	0	0.021523	0	23	56									
CIRBP	1153	broad.mit.edu	37	19	1271019	1271019	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:1271019C>T	uc002lrr.3	+	2	236	c.87C>T	c.(85-87)TAC>TAT	p.Y29Y	C19orf23_uc010xgk.1_5'Flank|CIRBP_uc010dsg.1_Missense_Mutation_p.T12M|CIRBP_uc002lrt.2_Silent_p.Y29Y|CIRBP_uc010xgl.1_Silent_p.Y29Y|CIRBP_uc002lrv.3_Silent_p.Y29Y|CIRBP_uc002lru.2_RNA	NM_001280	NP_001271	Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	29	RRM.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCAAAGTACGGACAGATCT	0.418		NaN											0	0	0	0.00874	0	41	159									
SPPL2B	56928	broad.mit.edu	37	19	2339822	2339822	+	Splice_Site	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:2339822G>A	uc002lvs.2	+	6	680	c.600_splice	c.e6-1	p.K200_splice	SPPL2B_uc010dsw.1_Splice_Site_p.K172_splice|SPPL2B_uc010dsy.1_Splice_Site_p.K172_splice|SPPL2B_uc010dsz.1_Splice_Site_p.K200_splice|SPPL2B_uc002lvr.2_Splice_Site_p.K200_splice|SPPL2B_uc010dta.1_Intron|SPPL2B_uc002lvu.2_Silent_p.K5K	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCTCCCAAGAAGGTACATG	0.677		NaN											0	0	0	0.001168	0	4	11									
CELF5	60680	broad.mit.edu	37	19	3251037	3251037	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:3251037C>T	uc002lxm.2	+	2	351	c.314C>T	c.(313-315)GCC>GTC	p.A105V	CELF5_uc002lxl.1_Missense_Mutation_p.A105V|CELF5_uc010dtj.1_Missense_Mutation_p.A105V|CELF5_uc010xhg.1_5'UTR	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	105	RRM 1.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						GCTCAGACTGCCCTGCACGAG	0.597		NaN											0	0	0	0.012319	0	23	80									
ADAMTS10	81794	broad.mit.edu	37	19	8670587	8670587	+	Silent	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:8670587G>T	uc002mkj.1	-	3	283	c.9C>A	c.(7-9)CCC>CCA	p.P3P	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	3					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCTGGCAGGCGGGAGCCATAG	0.682		NaN											1	0	0.000308642	0.003163	0.000392558	11	22									
MUC16	94025	broad.mit.edu	37	19	9063595	9063595	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:9063595T>A	uc002mkp.2	-	3	24055	c.23851A>T	c.(23851-23853)AGG>TGG	p.R7951W		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7953	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGACCCCTCCTCATAAGAGTG	0.463		NaN											0	0	0	0.00499	0	17	55									
RAVER1	125950	broad.mit.edu	37	19	10444084	10444084	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:10444084C>T	uc002moa.2	-	1	231	c.151G>A	c.(151-153)GAA>AAA	p.E51K		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	34						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GGCAGCTCTTCTTCCGGCGCC	0.672		NaN											0	0	0	0.009535	0	26	146									
SLC44A2	57153	broad.mit.edu	37	19	10745710	10745710	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:10745710G>A	uc002mpf.2	+	12	1155	c.1016G>A	c.(1015-1017)AGA>AAA	p.R339K	SLC44A2_uc002mpe.3_Missense_Mutation_p.R337K|SLC44A2_uc002mpg.1_Missense_Mutation_p.R59K|SLC44A2_uc002mph.2_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	339	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CTCCGGAAGAGAATTCTCATC	0.547		NaN											0	0	0	0.01441	0	64	234									
RAB3D	9545	broad.mit.edu	37	19	11446394	11446394	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:11446394G>C	uc002mqy.2	-	3	532	c.294C>G	c.(292-294)TTC>TTG	p.F98L		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	98					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						ACATGAGCAGGAAGCCCATGG	0.587		NaN											0	0	0	0.009718	0	36	155									
IL27RA	9466	broad.mit.edu	37	19	14150615	14150615	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:14150615G>A	uc002mxx.2	+	4	850	c.427G>A	c.(427-429)GAC>AAC	p.D143N		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	143	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						TTCCGAGGATGACCCCCTGGA	0.607		NaN											0	0	0	0.01441	0	91	45									
ASF1B	55723	broad.mit.edu	37	19	14231399	14231399	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:14231399C>A	uc002mye.2	-	4	653	c.481G>T	c.(481-483)GAG>TAG	p.E161*	PRKACA_uc002myc.2_5'Flank	NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	161					cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						TCTATGGCCTCCAGCCTGTCC	0.632		NaN											1	0	0.000422831	0.004007	0.00053697	15	39									
TECR	9524	broad.mit.edu	37	19	14675655	14675655	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:14675655C>G	uc002mza.2	+	8	674	c.547C>G	c.(547-549)CTC>GTC	p.L183V	TECR_uc002mzb.2_Missense_Mutation_p.L198V|TECR_uc010xns.1_Missense_Mutation_p.L28V|TECR_uc002mzc.2_Missense_Mutation_p.L28V|TECR_uc002mzd.2_Missense_Mutation_p.L183V|TECR_uc002mze.2_Missense_Mutation_p.L9V|TECR_uc002mzf.1_5'Flank	NM_138501	NP_612510	Q9NZ01	TECR_HUMAN	glycoprotein, synaptic 2	183					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity				0						CAATCACCCTCTCTACACTCC	0.632		NaN											0	0	0	0.010504	0	20	127									
OCEL1	79629	broad.mit.edu	37	19	17337908	17337908	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17337908G>A	uc002nfp.2	+	3	354	c.352G>A	c.(352-354)GAT>AAT	p.D118N		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	118										central_nervous_system(1)	1						TGTGTTTGAGGATGAGTTGCT	0.642		NaN											0	0	0	0.001984	0	6	171									
PLVAP	83483	broad.mit.edu	37	19	17476638	17476638	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17476638C>G	uc002ngk.1	-	3	686	c.636G>C	c.(634-636)CAG>CAC	p.Q212H		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	212	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CCTTGGCCAGCTGGCGCTCTT	0.562		NaN											0	0	0	0.004656	0	24	92									
UNC13A	23025	broad.mit.edu	37	19	17735691	17735691	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17735691C>T	uc002nhd.2	-	35	4408	c.4408G>A	c.(4408-4410)GTT>ATT	p.V1470I		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1382	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GTGTTCATAACCAGCTTCCAC	0.597		NaN											0	0	0	0.006214	0	9	44									
UNC13A	23025	broad.mit.edu	37	19	17737462	17737462	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17737462G>A	uc002nhd.2	-	34	4317	c.4317C>T	c.(4315-4317)ATC>ATT	p.I1439I		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1351	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GCAGGTCCATGATGGGCTGCA	0.647		NaN											0	0	0	0.004672	0	3	6									
ZNF536	9745	broad.mit.edu	37	19	31040280	31040280	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:31040280G>A	uc002nsu.1	+	4	3892	c.3754G>A	c.(3754-3756)GAG>AAG	p.E1252K	ZNF536_uc010edd.1_Missense_Mutation_p.E1252K	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCAAAGCCGGAGCGGGGGCC	0.612		NaN											0	0	0	0.008871	0	19	49									
CCDC123	84902	broad.mit.edu	37	19	33444536	33444536	+	Silent	SNP	C	C	T	rs140563444		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:33444536C>T	uc002nty.2	-	4	566	c.477G>A	c.(475-477)GTG>GTA	p.V159V	CCDC123_uc002ntx.2_5'UTR|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Silent_p.V159V|CCDC123_uc002nua.2_Silent_p.V159V|CCDC123_uc002nub.1_Silent_p.V51V	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	159						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					TTCTGTGTGGCACAGCGTACA	0.468		NaN											0	0	0	0.007413	0	17	741									
CHST8	64377	broad.mit.edu	37	19	34263476	34263476	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:34263476C>G	uc002nus.3	+	5	1288	c.783C>G	c.(781-783)TTC>TTG	p.F261L	CHST8_uc002nut.3_Missense_Mutation_p.F261L|CHST8_uc002nuu.2_Missense_Mutation_p.F261L	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	261	PAPS (By similarity).|Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					GCGAGCCCTTCGAGAGGCTGG	0.612		NaN											0	0	0	0.007413	0	18	191									
FFAR3	2865	broad.mit.edu	37	19	35850555	35850555	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:35850555C>G	uc002nzd.2	+	2	838	c.763C>G	c.(763-765)CCG>GCG	p.P255A	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	255	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CGGTGAAAGCCCGGCGTGGAG	0.592		NaN											0	0	0	0.019004	0	34	583									
IL28A	282616	broad.mit.edu	37	19	39759824	39759824	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:39759824C>A	uc002oku.1	+	3	277	c.225C>A	c.(223-225)TGC>TGA	p.C75*		NM_172138	NP_742150	Q8IZJ0	IL28A_HUMAN	interleukin 28A precursor	75					response to virus	extracellular space	cytokine activity			ovary(1)|skin(1)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;5.39e-26)|all cancers(26;4.1e-23)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			ACTGCAGGTGCCACTCCCGCC	0.637		NaN											1	0	8.12818e-05	0.001984	0.000104505	6	26									
CD3EAP	10849	broad.mit.edu	37	19	45910367	45910367	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:45910367C>T	uc002pbq.1	+	2	526	c.38C>T	c.(37-39)TCT>TTT	p.S13F	PPP1R13L_uc002pbn.2_5'Flank|PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Missense_Mutation_p.S15F	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	13					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		GCTCGGTTCTCTTGTCCCCCC	0.592		NaN											0	0	0	0.005443	0	27	221									
GRLF1	2909	broad.mit.edu	37	19	47502569	47502569	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:47502569G>A	uc010ekv.2	+	5	4045	c.4045G>A	c.(4045-4047)GAC>AAC	p.D1349N		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1349	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		AGAAATCAACGACCGGGAGCA	0.493		NaN											0	0	0	0.00308	0	7	15									
PTOV1	53635	broad.mit.edu	37	19	50361229	50361229	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50361229G>C	uc002pqf.1	+	8	1043	c.873G>C	c.(871-873)GAG>GAC	p.E291D	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Missense_Mutation_p.E259D|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	291	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		ACCAGGGGGAGATCCTGTGAG	0.652		NaN											0	0	0	0.009096	0	4	123									
TBC1D17	79735	broad.mit.edu	37	19	50387551	50387551	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50387551G>C	uc002pqo.2	+	11	1320	c.1168G>C	c.(1168-1170)GAG>CAG	p.E390Q	TBC1D17_uc010ybg.1_Missense_Mutation_p.E357Q|TBC1D17_uc002pqp.2_Missense_Mutation_p.E41Q|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.E41Q|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	390	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CAAGTTCTACGAGGGTCCCGA	0.632		NaN											0	0	0	0.010771	0	44	310									
TBC1D17	79735	broad.mit.edu	37	19	50387587	50387587	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50387587G>A	uc002pqo.2	+	11	1356	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N	TBC1D17_uc010ybg.1_Missense_Mutation_p.D369N|TBC1D17_uc002pqp.2_Missense_Mutation_p.D53N|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.D53N|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	402	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCTGCTGAACGATATCCTCCT	0.662		NaN											0	0	0	0.01441	0	64	400									
TBC1D17	79735	broad.mit.edu	37	19	50387778	50387778	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50387778G>C	uc002pqo.2	+	12	1458	c.1306G>C	c.(1306-1308)GAT>CAT	p.D436H	TBC1D17_uc010ybg.1_Missense_Mutation_p.D403H|TBC1D17_uc002pqp.2_Missense_Mutation_p.D87H|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.D87H|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	436	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GAACGAGGTGGATGCTTTCTG	0.592		NaN											0	0	0	0.019004	0	35	237									
FPR1	2357	broad.mit.edu	37	19	52249881	52249881	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:52249881G>A	uc002pxq.2	-	2	462	c.367C>T	c.(367-369)CGC>TGC	p.R123C		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	123	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CAAACACAGCGGTCCAGAGCA	0.552		NaN											0	0	0	0.005524	0	39	79									
ZNF649	65251	broad.mit.edu	37	19	52393957	52393957	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:52393957G>A	uc002pxy.2	-	5	1700	c.1432C>T	c.(1432-1434)CAT>TAT	p.H478Y	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_Intron	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CCCTGCACATGTTCACTAGGA	0.318		NaN											0	0	0	0.003163	0	15	319									
ZNF615	284370	broad.mit.edu	37	19	52507119	52507119	+	Translation_Start_Site	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:52507119T>A	uc002pye.1	-	3	138	c.-154A>T	c.(-156--152)GAAGG>GATGG		ZNF615_uc002pyf.1_Translation_Start_Site|ZNF615_uc002pyg.1_Translation_Start_Site|ZNF615_uc002pyh.1_Translation_Start_Site|ZNF615_uc010epi.1_Intron|ZNF615_uc010ydg.1_Intron	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCCTCCTTCCTTCACTTGATT	0.428		NaN											0	0	0	0.009096	0	4	14									
ZNF816A	125893	broad.mit.edu	37	19	53453850	53453850	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:53453850C>G	uc002qal.1	-	5	1479	c.1178G>C	c.(1177-1179)GGA>GCA	p.G393A	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.G377A	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		AGGTTTCTCTCCAGTGTGAAG	0.393		NaN											0	0	0	0.01441	0	86	130									
RPL28	6158	broad.mit.edu	37	19	55897738	55897738	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:55897738C>G	uc002qkv.2	+	2	55	c.13C>G	c.(13-15)CTG>GTG	p.L5V	uc002qku.2_5'Flank|RPL28_uc010yfz.1_Missense_Mutation_p.L5V|RPL28_uc010yfy.1_Missense_Mutation_p.L5V|RPL28_uc010yga.1_Missense_Mutation_p.L5V|RPL28_uc010ygb.1_Missense_Mutation_p.L5V|RPL28_uc002qkw.1_Missense_Mutation_p.L5V	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	5					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		GTCTGCGCATCTGCAATGGAT	0.607		NaN											0	0	0	0.00499	0	17	50									
UBE2S	27338	broad.mit.edu	37	19	55918274	55918274	+	Silent	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:55918274C>A	uc002qkx.1	-	2	428	c.60G>T	c.(58-60)GTG>GTT	p.V20V	uc002qky.2_5'Flank	NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	20					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCAGTGTCGTCACCTCCTTGT	0.602		NaN											1	0	2.27525e-19	0.021523	3.18228e-19	25	159									
ZNF581	51545	broad.mit.edu	37	19	56156283	56156283	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:56156283G>T	uc002qln.2	+	2	1062	c.346G>T	c.(346-348)GAG>TAG	p.E116*	ZNF581_uc002qlq.2_Nonsense_Mutation_p.E116*|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	116	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AAAGCCCTTCGAGTGTGACAT	0.607		NaN											1	0	0.00307968	0.00308	0.00387534	7	223									
U2AF2	11338	broad.mit.edu	37	19	56175100	56175100	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:56175100C>G	uc002qlu.2	+	7	1787	c.732C>G	c.(730-732)GTC>GTG	p.V244V	U2AF2_uc002qlt.2_Silent_p.V244V	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	244					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		ACCCCTCCGTCTATGTGCCTG	0.587		NaN											0	0	0	0.01441	0	86	196									
ZFP28	140612	broad.mit.edu	37	19	57058946	57058946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:57058946C>T	uc002qnj.2	+	3	441	c.370C>T	c.(370-372)CAG>TAG	p.Q124*	ZFP28_uc002qni.2_Nonsense_Mutation_p.Q124*|uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	124	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GAACCCCATTCAGAGGAACTT	0.527		NaN											0	0	0	0.006122	0	19	94									
AURKC	6795	broad.mit.edu	37	19	57744973	57744973	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:57744973T>A	uc002qoe.2	+	5	770	c.581T>A	c.(580-582)CTG>CAG	p.L194Q	AURKC_uc002qoc.2_Missense_Mutation_p.L175Q|AURKC_uc002qod.2_Missense_Mutation_p.L160Q|AURKC_uc010etv.2_Missense_Mutation_p.L191Q	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	194	Protein kinase.			SLR -> LPE (in Ref. 2; AAC77369).	cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ACCCCCTCCCTGAGGTAGGTC	0.483		NaN											0	0	0	0.005443	0	27	144									
TPO	7173	broad.mit.edu	37	2	1481320	1481320	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:1481320T>A	uc002qww.2	+	8	1373	c.1282T>A	c.(1282-1284)TGG>AGG	p.W428R	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.W428R|TPO_uc002qwr.2_Missense_Mutation_p.W428R|TPO_uc002qwx.2_Missense_Mutation_p.W428R|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.W428R	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	428	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAATGCGCACTGGAGCGCGGA	0.741		NaN											0	0	0	0.00308	0	7	9									
C2orf44	80304	broad.mit.edu	37	2	24261333	24261333	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:24261333C>G	uc002rep.2	-	2	1163	c.1032G>C	c.(1030-1032)CTG>CTC	p.L344L	C2orf44_uc010eya.2_Silent_p.L344L	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	344							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAAATGCTATCAGATCAGGAA	0.418		NaN											0	0	0	0.009096	0	4	93									
ADCY3	109	broad.mit.edu	37	2	25141819	25141819	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:25141819G>A	uc002rfs.3	-	1	237	c.38C>T	c.(37-39)TCG>TTG	p.S13L	ADCY3_uc010ykm.1_Missense_Mutation_p.S13L	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	13	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					gtactcggccgagtattcggG	0.542		NaN											0	0	0	0.014758	0	4	21									
OTOF	9381	broad.mit.edu	37	2	26706369	26706369	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:26706369G>C	uc002rhk.2	-	13	1480	c.1353C>G	c.(1351-1353)CTC>CTG	p.L451L		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	451	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGGGTCCACGAGGTCCTTGT	0.537		NaN											0	0	0	0.003163	0	15	92									
C2orf16	84226	broad.mit.edu	37	2	27804486	27804486	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:27804486G>C	uc002rkz.3	+	1	5098	c.5047G>C	c.(5047-5049)GAG>CAG	p.E1683Q	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1683	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.|7.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CGGTCCCTCAGAGAGAAGCCA	0.567		NaN											0	0	0	0.010729	0	11	342									
BIRC6	57448	broad.mit.edu	37	2	32743962	32743962	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:32743962C>T	uc010ezu.2	+	57	11706	c.11572C>T	c.(11572-11574)CTT>TTT	p.L3858F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3858					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATTCCGTACTCTTCATTTGCC	0.368		NaN											0	0	0	0.004482	0	7	36									
BIRC6	57448	broad.mit.edu	37	2	32743965	32743965	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:32743965C>T	uc010ezu.2	+	57	11709	c.11575C>T	c.(11575-11577)CAT>TAT	p.H3859Y		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3859					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CCGTACTCTTCATTTGCCAGT	0.363		NaN											0	0	0	0.004482	0	7	36									
BIRC6	57448	broad.mit.edu	37	2	32743998	32743998	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:32743998C>G	uc010ezu.2	+	57	11742	c.11608C>G	c.(11608-11610)CTT>GTT	p.L3870V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3870					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATCAGATGTTCTTGACAGAGT	0.348		NaN											0	0	0	0.014758	0	5	27									
PRKD3	23683	broad.mit.edu	37	2	37505009	37505009	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:37505009C>G	uc002rqd.2	-	8	1851	c.1296G>C	c.(1294-1296)CTG>CTC	p.L432L	PRKD3_uc002rqe.1_Silent_p.L32L|PRKD3_uc002rqf.1_Silent_p.L432L	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	432	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GATTACTGACCAGGTTATCCC	0.378		NaN											0	0	0	0.005524	0	36	83									
PLEKHH2	130271	broad.mit.edu	37	2	43953483	43953483	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:43953483G>C	uc010yny.1	+	17	2697	c.2614G>C	c.(2614-2616)GAT>CAT	p.D872H	PLEKHH2_uc002rtf.3_Missense_Mutation_p.D871H	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	872	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTCAGATGAAGATTATGAAGC	0.398		NaN											0	0	0	0.004672	0	3	51									
SIX3	6496	broad.mit.edu	37	2	45171878	45171878	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:45171878C>G	uc002run.1	+	2	1185	c.978C>G	c.(976-978)AGC>AGG	p.S326R		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	326					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TAACCTCCAGCGACTCGGAAT	0.448		NaN											0	0	0	0.009096	0	3	9									
PAIP2B	400961	broad.mit.edu	37	2	71415650	71415650	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:71415650T>C	uc002shu.2	-	4	518	c.331A>G	c.(331-333)AAC>GAC	p.N111D		NM_020459	NP_065192	Q9ULR5	PAI2B_HUMAN	poly(A) binding protein interacting protein 2B	111					negative regulation of translational initiation		protein binding|translation repressor activity, nucleic acid binding				0						GCATCTGGGTTCAGGTTACTT	0.433		NaN											0	0	0	0.004672	0	3	21									
RAB11FIP5	26056	broad.mit.edu	37	2	73316194	73316194	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:73316194C>G	uc002siu.3	-	2	922	c.681G>C	c.(679-681)AAG>AAC	p.K227N	RAB11FIP5_uc002sit.3_Missense_Mutation_p.K149N	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	227					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CTTTGCCCATCTTGCCCAGGC	0.587		NaN											0	0	0	0.009535	0	31	134									
SEMA4F	10505	broad.mit.edu	37	2	74900804	74900804	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:74900804C>T	uc002sna.1	+	7	782	c.671C>T	c.(670-672)GCC>GTC	p.A224V	SEMA4F_uc010ysb.1_3'UTR|SEMA4F_uc010ffq.1_Missense_Mutation_p.A191V|SEMA4F_uc010ffr.1_Intron|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	224	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTATTCCCAGCCCCAGCCTTT	0.592		NaN											0	0	0	0.005443	0	28	57									
TACR1	6869	broad.mit.edu	37	2	75425676	75425676	+	Missense_Mutation	SNP	C	C	G	rs77755890		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:75425676C>G	uc002sng.2	-	1	970	c.385G>C	c.(385-387)GAT>CAT	p.D129H	TACR1_uc002snh.2_Missense_Mutation_p.D129H	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	129	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TCTCACCTATCAAAGGCCACA	0.512		NaN											0	0	0	0.001984	0	7	103									
REG1A	5967	broad.mit.edu	37	2	79347991	79347991	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:79347991G>T	uc002snz.2	+	2	107	c.4G>T	c.(4-6)GCT>TCT	p.A2S	REG1A_uc010ffx.1_Missense_Mutation_p.A2S|REG1A_uc010ysd.1_Missense_Mutation_p.A2S	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	2					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GCTCAGCATGGCTCAGACCAG	0.473		NaN											1	0	5.9392e-07	0.001168	7.88086e-07	5	48									
POLR1A	25885	broad.mit.edu	37	2	86280076	86280076	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:86280076C>T	uc002sqs.2	-	16	2635	c.2256G>A	c.(2254-2256)GCG>GCA	p.A752A	POLR1A_uc010ytb.1_Silent_p.A118A	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	752					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TCCCATAGTGCGCCTTGTCCA	0.632		NaN											0	0	0	0.007291	0	28	39									
RPIA	22934	broad.mit.edu	37	2	89034118	89034118	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:89034118T>C	uc002ste.2	+	5	553	c.512T>C	c.(511-513)CTC>CCC	p.L171P		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	171					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				GATCTCAATCTCATCAAGGGT	0.448		NaN											0	0	0	0.009535	0	31	62									
GPAT2	150763	broad.mit.edu	37	2	96687951	96687951	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:96687951G>C	uc002svf.2	-	22	2567	c.2344C>G	c.(2344-2346)CAG>GAG	p.Q782E	LOC729234_uc010fht.2_Intron|GPAT2_uc002svd.2_Missense_Mutation_p.Q601E|GPAT2_uc002sve.2_Missense_Mutation_p.Q584E|GPAT2_uc002svg.2_Missense_Mutation_p.Q661E|GPAT2_uc010yuh.1_Missense_Mutation_p.Q711E|GPAT2_uc002svh.2_3'UTR	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	782					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						AGTTTTTCCTGATTGTCCAGG	0.562		NaN											0	0	0	0.008871	0	16	25									
REV1	51455	broad.mit.edu	37	2	100020219	100020219	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:100020219C>T	uc002tad.2	-	19	3317	c.3105G>A	c.(3103-3105)GCG>GCA	p.A1035A	REV1_uc002tac.2_Silent_p.A1034A	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	1035					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding	p.A1035A(1)		ovary(2)	2						TTTGATCATACGCTGCTTTCA	0.498		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	54	70									
IL18R1	8809	broad.mit.edu	37	2	102984374	102984374	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:102984374G>A	uc002tbw.3	+	3	298	c.148G>A	c.(148-150)GAA>AAA	p.E50K	IL18R1_uc010ywb.1_Missense_Mutation_p.E50K|IL18R1_uc010ywc.1_Missense_Mutation_p.E50K|IL18R1_uc010ywd.1_Intron|IL18R1_uc010fiy.2_Missense_Mutation_p.E50K	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	50	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity	p.E50K(1)		ovary(2)|pancreas(1)	3						ACATGAGATTGAAACAACCAC	0.428		NaN											0	0	0	0.009096	0	4	45									
SLC9A4	389015	broad.mit.edu	37	2	103119941	103119941	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:103119941T>G	uc002tbz.3	+	3	1212	c.755T>G	c.(754-756)ATG>AGG	p.M252R		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	252	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						TTTACAAAGATGCATAAATTT	0.373		NaN											0	0	0	0.014758	0	5	31									
GCC2	9648	broad.mit.edu	37	2	109087478	109087478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:109087478C>T	uc002tec.2	+	6	1847	c.1693C>T	c.(1693-1695)CAA>TAA	p.Q565*	GCC2_uc002ted.2_Nonsense_Mutation_p.Q464*	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	565	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAAGAACCTTCAAGAAAAGAA	0.204		NaN											0	0	0	0.001984	0	7	29									
UGGT1	56886	broad.mit.edu	37	2	128913070	128913070	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:128913070C>T	uc002tps.2	+	20	2323	c.2145C>T	c.(2143-2145)TTC>TTT	p.F715F	UGGT1_uc010fme.1_Silent_p.F590F|UGGT1_uc002tpr.2_Silent_p.F691F	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	715					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						CAGATAACTTCTTTGTGGATG	0.323		NaN											0	0	0	0.001168	0	6	42									
NXPH2	11249	broad.mit.edu	37	2	139428601	139428601	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:139428601T>C	uc002tvi.2	-	2	686	c.686A>G	c.(685-687)AAG>AGG	p.K229R		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	229	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		GCAAATGACCTTGAAGGGCTT	0.468		NaN											0	0	0	0.010504	0	21	16									
LRP1B	53353	broad.mit.edu	37	2	141806780	141806780	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:141806780C>G	uc002tvj.1	-	11	2536	c.1564G>C	c.(1564-1566)GAG>CAG	p.E522Q	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	522	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGAACAACTCATTCTTTGGT	0.398		NaN								TSP Lung(27;0.18)			0	0	0	0.008291	0	10	21									
BAZ2B	29994	broad.mit.edu	37	2	160194090	160194090	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:160194090T>A	uc002uao.2	-	32	6000	c.5648A>T	c.(5647-5649)AAC>ATC	p.N1883I	BAZ2B_uc002uap.2_Missense_Mutation_p.N1847I	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1883					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TCTTTCAATGTTCCGCTCCAA	0.483		NaN											0	0	0	0.015359	0	35	89									
BAZ2B	29994	broad.mit.edu	37	2	160206576	160206576	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:160206576G>C	uc002uao.2	-	28	4858	c.4506C>G	c.(4504-4506)AAC>AAG	p.N1502K	BAZ2B_uc002uap.2_Missense_Mutation_p.N1466K	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GTTTTCCACTGTTCTGATAAG	0.448		NaN											0	0	0	0.004007	0	17	43									
SCN1A	6323	broad.mit.edu	37	2	166850897	166850897	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:166850897G>T	uc010zcz.1	-	25	4596	c.4578C>A	c.(4576-4578)TTC>TTA	p.F1526L		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1537	Helical; Name=S1 of repeat IV; (By similarity).|IV.			F -> L (in Ref. 7; CAA46439/M91803).		voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTCTGGTTACGAAGTCAAAGA	0.353		NaN											1	0	1.23904e-05	0.014758	1.61056e-05	4	10									
XIRP2	129446	broad.mit.edu	37	2	168105339	168105339	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:168105339G>A	uc002udx.2	+	8	7455	c.7437G>A	c.(7435-7437)CAG>CAA	p.Q2479Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.Q2304Q|XIRP2_uc010fpq.2_Silent_p.Q2257Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2304					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGACAAAGCAGAACGTTATTA	0.403		NaN											0	0	0	0.013537	0	13	15									
LRP2	4036	broad.mit.edu	37	2	170019001	170019001	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:170019001C>A	uc002ues.2	-	63	12081	c.11868G>T	c.(11866-11868)TGG>TGT	p.W3956C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3956	LDL-receptor class A 36.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTTCATCGGACCAGTCACCAC	0.388		NaN											1	0	3.65163e-15	0.00632	5.03086e-15	27	47									
SLC25A12	8604	broad.mit.edu	37	2	172749752	172749752	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:172749752C>T	uc002uhh.2	-	2	118	c.29G>A	c.(28-30)CGA>CAA	p.R10Q	SLC25A12_uc010fqh.2_5'UTR|SLC25A12_uc010zdv.1_RNA	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	10					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	AGGATCCCCTCGCTTAGTTGT	0.393		NaN											0	0	0	0.008361	0	27	133									
TTN	7273	broad.mit.edu	37	2	179399173	179399173	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179399173C>A	uc010zfg.1	-	307	94689	c.94465G>T	c.(94465-94467)GAG>TAG	p.E31489*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E25184*|TTN_uc010zfi.1_Nonsense_Mutation_p.E25117*|TTN_uc010zfj.1_Nonsense_Mutation_p.E24992*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32416							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTTCCTCTCTTTCACTAAC	0.398		NaN											1	0	1.26454e-06	0.005443	1.67527e-06	25	98									
TTN	7273	broad.mit.edu	37	2	179444828	179444828	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179444828C>G	uc010zfg.1	-	267	59706	c.59482G>C	c.(59482-59484)GCA>CCA	p.A19828P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A13523P|TTN_uc010zfi.1_Missense_Mutation_p.A13456P|TTN_uc010zfj.1_Missense_Mutation_p.A13331P|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20755							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTCTCTGCATCACGTTTT	0.438		NaN											0	0	0	0.003163	0	15	106									
TTN	7273	broad.mit.edu	37	2	179578817	179578817	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179578817G>C	uc010zfg.1	-	89	23060	c.22836C>G	c.(22834-22836)ACC>ACG	p.T7612T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T4273T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8539							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGTTCAGGGGTGCCAGCTA	0.413		NaN											0	0	0	0.013537	0	13	17									
TTN	7273	broad.mit.edu	37	2	179579153	179579153	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179579153A>G	uc010zfg.1	-	88	22840	c.22616T>C	c.(22615-22617)ATA>ACA	p.I7539T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I4200T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8466							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAATCCATATGTTGTCACT	0.413		NaN											0	0	0	0.004007	0	17	23									
TTN	7273	broad.mit.edu	37	2	179642507	179642507	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179642507A>C	uc010zfg.1	-	25	4628	c.4404T>G	c.(4402-4404)TGT>TGG	p.C1468W	TTN_uc010zfh.1_Missense_Mutation_p.C1422W|TTN_uc010zfi.1_Missense_Mutation_p.C1422W|TTN_uc010zfj.1_Missense_Mutation_p.C1422W|TTN_uc002unb.2_Missense_Mutation_p.C1468W|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1468							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCCTTCTAAACATTTGAAAG	0.418		NaN											0	0	0	0.013537	0	12	59									
DNAH7	56171	broad.mit.edu	37	2	196602713	196602713	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:196602713G>A	uc002utj.3	-	65	12108	c.12007C>T	c.(12007-12009)CCC>TCC	p.P4003S	DNAH7_uc002uti.3_Missense_Mutation_p.P486S	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	4003					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGGTCAGAGGGAAGAGTCATG	0.438		NaN											0	0	0	0.00308	0	7	41									
CFLAR	8837	broad.mit.edu	37	2	202000716	202000716	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:202000716G>A	uc002uxb.3	+	4	861	c.409G>A	c.(409-411)GAG>AAG	p.E137K	CFLAR_uc002uwy.2_Missense_Mutation_p.E137K|CFLAR_uc002uwz.2_Missense_Mutation_p.E137K|CFLAR_uc002uxa.3_Missense_Mutation_p.E137K|CFLAR_uc010zhk.1_Missense_Mutation_p.E41K|CFLAR_uc002uxc.3_Missense_Mutation_p.E137K|CFLAR_uc010zhl.1_Missense_Mutation_p.E41K|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Missense_Mutation_p.E137K|CFLAR_uc002uxe.2_Missense_Mutation_p.E137K|CFLAR_uc002uxf.2_Missense_Mutation_p.E137K|CFLAR_uc010fsy.2_RNA|CFLAR_uc010fsx.2_Missense_Mutation_p.E137K|CFLAR_uc010zhm.1_Missense_Mutation_p.E41K|CFLAR_uc010fsz.2_5'UTR	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	137	Interaction with FADD.|Interaction with caspase-8.|DED 2.|Not proteolytically processed and involved in apoptosis inhibition.|Interaction with caspase-8 propeptide.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						CCTTGTGGTTGAGTTGGAGAA	0.313		NaN											0	0	0	0.008361	0	28	139									
BMPR2	659	broad.mit.edu	37	2	203420499	203420499	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:203420499C>G	uc002uzf.3	+	12	3259	c.2111C>G	c.(2110-2112)TCT>TGT	p.S704C	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	704	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AGTACTAGTTCTAGCTTGCTT	0.443		NaN											0	0	0	0.009096	0	4	102									
ABCA12	26154	broad.mit.edu	37	2	215851389	215851389	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:215851389G>A	uc002vew.2	-	28	4260	c.4040C>T	c.(4039-4041)GCC>GTC	p.A1347V	ABCA12_uc002vev.2_Missense_Mutation_p.A1029V|ABCA12_uc010zjn.1_Missense_Mutation_p.A274V	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1347	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCCATGCAGGGCAACCCCGAC	0.438		NaN											0	0	0	0.014758	0	4	64									
STK36	27148	broad.mit.edu	37	2	219559043	219559043	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:219559043C>T	uc002viu.2	+	20	2659	c.2393C>T	c.(2392-2394)TCT>TTT	p.S798F	STK36_uc002viv.2_Missense_Mutation_p.S798F|STK36_uc002viw.2_5'Flank|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	798					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CATGTCGTCTCTCTTGTGGTA	0.458		NaN											0	0	0	0.008291	0	8	195									
COL4A3	1285	broad.mit.edu	37	2	228148486	228148486	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:228148486A>T	uc002vom.1	+	33	2822	c.2660A>T	c.(2659-2661)GAA>GTA	p.E887V	COL4A3_uc002von.1_Missense_Mutation_p.E887V|COL4A3_uc002voo.1_Missense_Mutation_p.E887V|COL4A3_uc002vop.1_Missense_Mutation_p.E887V|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	887	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TCCATAGGTGAAGATGGAGTG	0.458		NaN											0	0	0	0.009718	0	40	111									
SPHKAP	80309	broad.mit.edu	37	2	228881823	228881823	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:228881823C>T	uc002vpq.2	-	7	3794	c.3747G>A	c.(3745-3747)CTG>CTA	p.L1249L	SPHKAP_uc002vpp.2_Silent_p.L1249L|SPHKAP_uc010zlx.1_Silent_p.L1249L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1249						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATTCACTGTCAGCCTGGAGC	0.567		NaN											0	0	0	0.016723	0	13	91									
SPHKAP	80309	broad.mit.edu	37	2	228882099	228882099	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:228882099G>C	uc002vpq.2	-	7	3518	c.3471C>G	c.(3469-3471)AGC>AGG	p.S1157R	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1157R|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1157R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1157						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCAGAATGCTGCTGGCGTTCT	0.512		NaN											0	0	0	0.008291	0	11	79									
DEFB128	245939	broad.mit.edu	37	20	168750	168750	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:168750C>T	uc002wcz.1	-	2	59	c.59G>A	c.(58-60)AGA>AAA	p.R20K		NM_001037732	NP_001032821	Q7Z7B8	DB128_HUMAN	beta-defensin 128 precursor	20					defense response to bacterium	extracellular region		p.R20fs*4(1)		breast(1)	1		all_cancers(10;0.00499)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TTTTTTGAGTCTTGCCCCGTC	0.423		NaN											0	0	0	0.00308	0	7	95									
TMC2	117532	broad.mit.edu	37	20	2573052	2573052	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:2573052G>C	uc002wgf.1	+	8	946	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	TMC2_uc002wgg.1_Missense_Mutation_p.E295Q|TMC2_uc010zpw.1_Missense_Mutation_p.E143Q|TMC2_uc010zpx.1_Missense_Mutation_p.E142Q	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	311	Extracellular (Potential).					integral to membrane				ovary(3)	3						TTGGGATTTTGAGGTACTATT	0.403		NaN											0	0	0	0.01441	0	70	113									
CDC25B	994	broad.mit.edu	37	20	3783805	3783805	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:3783805G>A	uc002wjn.2	+	13	2086	c.1308G>A	c.(1306-1308)GTG>GTA	p.V436V	CDC25B_uc010zqk.1_Silent_p.V372V|CDC25B_uc010zql.1_Silent_p.V358V|CDC25B_uc010zqm.1_Silent_p.V345V|CDC25B_uc002wjl.2_Silent_p.V324V|CDC25B_uc002wjm.2_Silent_p.V324V|CDC25B_uc002wjo.2_Silent_p.V422V|CDC25B_uc002wjp.2_Silent_p.V395V|CDC25B_uc002wjq.2_Silent_p.V236V|CDC25B_uc010gbc.2_Silent_p.V17V	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	436	Rhodanese.				cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						ATAAGTTTGTGATTGTAGACT	0.547		NaN											0	0	0	0.010818	0	29	55									
RIN2	54453	broad.mit.edu	37	20	19956386	19956386	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:19956386G>C	uc002wro.1	+	7	1753	c.1717G>C	c.(1717-1719)GAG>CAG	p.E573Q	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Missense_Mutation_p.E367Q	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	573					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TCAGAGCTCGGAGCTGGACCC	0.507		NaN											0	0	0	0.013537	0	12	41									
ZNF337	26152	broad.mit.edu	37	20	25656356	25656356	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:25656356C>T	uc002wva.2	-	4	2090	c.1568G>A	c.(1567-1569)CGA>CAA	p.R523Q	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.R491Q|ZNF337_uc002wvb.2_Missense_Mutation_p.R523Q|ZNF337_uc002wvc.2_Missense_Mutation_p.R523Q	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	523	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGTAAAGCCTCGCCCACAATC	0.488		NaN											0	0	0	0.010729	0	12	156									
MYLK2	85366	broad.mit.edu	37	20	30408240	30408240	+	Missense_Mutation	SNP	G	G	A	rs34471514		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:30408240G>A	uc002wwq.2	+	3	466	c.364G>A	c.(364-366)GAT>AAT	p.D122N		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	122					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGGCAGCCAGGATCCTGGAAA	0.667		NaN											0	0	0	0.015359	0	31	109									
CBFA2T2	9139	broad.mit.edu	37	20	32199130	32199130	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:32199130C>T	uc002wzg.1	+	4	973	c.436C>T	c.(436-438)CTT>TTT	p.L146F	CBFA2T2_uc010zug.1_Intron|CBFA2T2_uc002wze.1_Missense_Mutation_p.L137F|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.L117F|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	146	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						GACTCTTGTTCTTGCACTGGT	0.478		NaN											0	0	0	0.020292	0	15	134									
TRPC4AP	26133	broad.mit.edu	37	20	33596493	33596493	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:33596493C>T	uc002xbk.2	-	13	1603	c.1569G>A	c.(1567-1569)AAG>AAA	p.K523K	TRPC4AP_uc002xbj.2_5'Flank|TRPC4AP_uc010zuq.1_Silent_p.K114K|TRPC4AP_uc002xbl.2_Silent_p.K515K|TRPC4AP_uc010zur.1_Silent_p.K484K|TRPC4AP_uc002xbm.1_Silent_p.K523K	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	523					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			CTGGCTCCTTCTTCATGACCT	0.507		NaN											0	0	0	0.01441	0	82	281									
CPNE1	8904	broad.mit.edu	37	20	34219936	34219936	+	Silent	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:34219936T>A	uc002xdf.2	-	8	831	c.468A>T	c.(466-468)GGA>GGT	p.G156G	CPNE1_uc002xdc.2_5'Flank|CPNE1_uc010zvj.1_Silent_p.G161G|CPNE1_uc002xde.2_Silent_p.G132G|CPNE1_uc002xdg.2_Silent_p.G156G|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Silent_p.G156G|CPNE1_uc002xdi.2_Silent_p.G156G|CPNE1_uc002xdj.2_Silent_p.G156G|CPNE1_uc002xdk.2_Silent_p.G156G|CPNE1_uc002xdl.2_Silent_p.G156G|CPNE1_uc002xdm.2_Silent_p.G156G|CPNE1_uc010gfk.1_Silent_p.G156G	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	156	C2 2.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GATCTGATTTTCCCAGGAAGT	0.537		NaN											0	0	0	0.021523	0	25	162									
C20orf152	140894	broad.mit.edu	37	20	34596337	34596337	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:34596337C>T	uc002xes.1	+	9	1245	c.1089C>T	c.(1087-1089)TTC>TTT	p.F363F	C20orf152_uc002xer.1_Silent_p.F363F|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	363											0	Breast(12;0.00631)					GGACAAGCTTCAGCAGGAAGA	0.502		NaN											0	0	0	0.016723	0	13	147									
SRC	6714	broad.mit.edu	37	20	36030892	36030892	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:36030892C>T	uc002xgx.2	+	12	1620	c.1171C>T	c.(1171-1173)CGT>TGT	p.R391C	SRC_uc002xgy.2_Missense_Mutation_p.R391C	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	391	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CCGGGACCTTCGTGCAGCCAA	0.627		NaN											0	0	0	0.001168	0	6	112									
KIAA0406	9675	broad.mit.edu	37	20	36625251	36625251	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:36625251G>A	uc002xhl.2	-	7	3107	c.2898C>T	c.(2896-2898)ATC>ATT	p.I966I	KIAA0406_uc002xhm.2_Silent_p.I966I	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	966							binding				0		Myeloproliferative disorder(115;0.00874)				CCCTGGCACTGATGGGGGCCT	0.597		NaN											0	0	0	0.01441	0	49	335									
MAFB	9935	broad.mit.edu	37	20	39316774	39316774	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:39316774C>T	uc002xji.2	-	1	1103	c.717G>A	c.(715-717)CTG>CTA	p.L239L		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	239	Basic motif.				negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				GCTTCTGCTTCAGGCGGATCA	0.632		NaN	T	IGH@	MM								0	0	0	0.00308	0	7	60									
SFRS6	6431	broad.mit.edu	37	20	42086760	42086760	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:42086760C>G	uc010zwg.1	+	1	257	c.87C>G	c.(85-87)CTC>CTG	p.L29L	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Silent_p.L29L	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	29	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GCCGCCTCCTCGAAGTAGACC	0.647		NaN											0	0	0	0.007413	0	17	87									
TOX2	84969	broad.mit.edu	37	20	42635186	42635186	+	Splice_Site	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:42635186G>A	uc002xlf.3	+	3	210	c.193_splice	c.e3-1	p.T65_splice	TOX2_uc010ggo.2_Splice_Site_p.T56_splice|TOX2_uc002xle.3_Splice_Site_p.T14_splice|TOX2_uc010ggp.2_Splice_Site_p.T14_splice|TOX2_uc002xlg.2_Splice_Site_p.T14_splice	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGATGTTTTAGACCTACAACG	0.453		NaN											0	0	0	0.010818	0	30	241									
WISP2	8839	broad.mit.edu	37	20	43355830	43355830	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:43355830T>A	uc002xmn.2	+	5	988	c.635T>A	c.(634-636)ATG>AAG	p.M212K	uc002xml.1_Intron|uc002xmm.1_Intron|WISP2_uc002xmp.2_Missense_Mutation_p.M212K|WISP2_uc002xmq.2_Missense_Mutation_p.W130R	NM_003881	NP_003872	O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	212	TSP type-1.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GGGCTGGGCATGGCCACCCGG	0.687		NaN											0	0	0	0.00874	0	43	128									
KCNK15	60598	broad.mit.edu	37	20	43379189	43379189	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:43379189A>C	uc002xmr.2	+	2	767	c.703A>C	c.(703-705)ATT>CTT	p.I235L		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	235	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GCTCACGGTCATTGGCGCCTT	0.612		NaN											0	0	0	0.01441	0	46	193									
PI3	5266	broad.mit.edu	37	20	43804728	43804728	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:43804728G>A	uc002xng.2	+	2	330	c.306G>A	c.(304-306)AAG>AAA	p.K102K		NM_002638	NP_002629	P19957	ELAF_HUMAN	elafin preproprotein	102	WAP.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CAGGAATCAAGAAGTGCTGTG	0.542		NaN											0	0	0	0.00499	0	16	134									
NCOA3	8202	broad.mit.edu	37	20	46279914	46279914	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:46279914C>T	uc002xtk.2	+	20	4045	c.3840C>T	c.(3838-3840)TTC>TTT	p.F1280F	NCOA3_uc010ght.1_Silent_p.F1271F|NCOA3_uc002xtl.2_Silent_p.F1276F|NCOA3_uc002xtm.2_Silent_p.F1275F|NCOA3_uc002xtn.2_Silent_p.F1279F|NCOA3_uc010zyc.1_Silent_p.F1075F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1280	Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CCCAGGCCTTCAGCCCACCTC	0.308		NaN											0	0	0	0.01892	0	25	100									
PREX1	57580	broad.mit.edu	37	20	47274684	47274684	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:47274684G>A	uc002xtw.1	-	17	1987	c.1964C>T	c.(1963-1965)TCG>TTG	p.S655L	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	655	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCAGCCAGCGAGCCCCTCTG	0.657		NaN									OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	285	545									
SLC9A8	23315	broad.mit.edu	37	20	48503325	48503325	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:48503325A>G	uc002xuv.1	+	15	1738	c.1528A>G	c.(1528-1530)ACG>GCG	p.T510A	SLC9A8_uc010zym.1_Missense_Mutation_p.T210A|SLC9A8_uc010gid.2_Missense_Mutation_p.T134A	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	510						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			GTCGGAGCTCACGGAGGAGGA	0.647		NaN											0	0	0	0.01441	0	100	100									
PCK1	5105	broad.mit.edu	37	20	56136482	56136482	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:56136482G>A	uc002xyn.3	+	2	178	c.15G>A	c.(13-15)CTG>CTA	p.L5L	PCK1_uc010zzm.1_5'UTR	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	5					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CTCCTCAGCTGCAAAACGGCC	0.527		NaN											0	0	0	0.010771	0	38	227									
GNAS	2778	broad.mit.edu	37	20	57429712	57429712	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:57429712T>A	uc002xzw.2	+	1	1677	c.1392T>A	c.(1390-1392)GAT>GAA	p.D464E	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CCCCAGCCGATCCAGATGCCG	0.796		NaN	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	0.001984	0	7	3									
PRIC285	85441	broad.mit.edu	37	20	62196310	62196310	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:62196310C>G	uc002yfm.2	-	9	4757	c.3865G>C	c.(3865-3867)GAG>CAG	p.E1289Q	PRIC285_uc002yfl.1_Missense_Mutation_p.E720Q	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1289					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTGCTGGCCTCAGGCAGCACC	0.672		NaN											0	0	0	0.004482	0	9	51									
UCKL1	54963	broad.mit.edu	37	20	62571633	62571633	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:62571633G>A	uc010gkn.2	-	14	1480	c.1437C>T	c.(1435-1437)ATC>ATT	p.I479I	UCKL1_uc002yhj.2_Silent_p.I122I|UCKL1_uc011abm.1_Silent_p.I464I|UCKL1_uc011abn.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	479					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ACAGCAAAAAGATCTTGTCCT	0.587		NaN											0	0	0	0.021022	0	34	53									
PRPF6	24148	broad.mit.edu	37	20	62624835	62624835	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:62624835C>G	uc002yho.2	+	4	603	c.435C>G	c.(433-435)CTC>CTG	p.L145L	PRPF6_uc002yhp.2_Silent_p.L145L	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	145					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TCTCAGACCTCAAGGTGAGCC	0.463		NaN											0	0	0	0.004656	0	23	38									
HSPA13	6782	broad.mit.edu	37	21	15746243	15746243	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:15746243C>G	uc002yjt.2	-	5	1180	c.1111G>C	c.(1111-1113)GAT>CAT	p.D371H	HSPA13_uc011abx.1_Missense_Mutation_p.D163H	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	371						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						TTAAGGGTATCAAAGAGTTTC	0.408		NaN											0	0	0	0.007835	0	40	115									
KRTAP13-3	337960	broad.mit.edu	37	21	31798111	31798111	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:31798111G>A	uc002yob.1	-	1	120	c.120C>T	c.(118-120)CTC>CTT	p.L40L		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	40						intermediate filament				ovary(1)|lung(1)	2						TGGGAGAGCAGAGGTCAGTGC	0.582		NaN											0	0	0	0.004482	0	8	82									
SON	6651	broad.mit.edu	37	21	34927545	34927545	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:34927545C>T	uc002yse.1	+	3	6057	c.6008C>T	c.(6007-6009)TCT>TTT	p.S2003F	SON_uc002ysb.1_Missense_Mutation_p.S2003F|SON_uc002ysc.2_Missense_Mutation_p.S2003F|SON_uc002ysd.2_Missense_Mutation_p.S994F|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S994F	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2003	2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V- V-R-R-R-S-F-S-I-S.|3-2.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AGATCAAGGTCTGTGGTAAGA	0.254		NaN											0	0	0	0.004656	0	25	126									
DOPEY2	9980	broad.mit.edu	37	21	37602841	37602841	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:37602841G>C	uc002yvg.2	+	14	1838	c.1759G>C	c.(1759-1761)GAG>CAG	p.E587Q	DOPEY2_uc011aeb.1_Missense_Mutation_p.E587Q	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	587					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCTGAAGTCTGAGGACAGTGG	0.507		NaN											0	0	0	0.007291	0	29	137									
DSCR3	10311	broad.mit.edu	37	21	38612875	38612875	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:38612875C>G	uc002ywf.1	-	3	362	c.123G>C	c.(121-123)TTG>TTC	p.L41F	DSCR3_uc010gnm.1_RNA|DSCR3_uc010gnn.1_5'UTR|DSCR3_uc010gnl.2_Missense_Mutation_p.L41F|DSCR3_uc011aeg.1_Missense_Mutation_p.L41F|DSCR3_uc011aeh.1_Intron	NM_006052	NP_006043	O14972	DSCR3_HUMAN	Down syndrome critical region protein 3	41					vacuolar transport	nucleus|retromer complex					0						CTTCCATGGTCAAAGACACTC	0.443		NaN											0	0	0	0.014758	0	4	96									
LCA5L	150082	broad.mit.edu	37	21	40800153	40800153	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:40800153C>T	uc002yxu.2	-	4	580	c.267G>A	c.(265-267)GTG>GTA	p.V89V	LCA5L_uc002yxv.2_Silent_p.V89V|LCA5L_uc002yxw.1_Silent_p.V89V|LCA5L_uc002yxx.1_Intron|LCA5L_uc002yxy.2_RNA	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	89											0		Prostate(19;1.2e-06)				TTTCTTTTACCACAGGCTGCT	0.323		NaN											0	0	0	0.01441	0	54	107									
UBASH3A	53347	broad.mit.edu	37	21	43833287	43833287	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:43833287G>A	uc002zbe.2	+	4	545	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	UBASH3A_uc002zbf.2_Missense_Mutation_p.R170Q|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.R170Q	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	170						cytosol|nucleus				ovary(3)	3						GACGTCATCCGGGAATTCGCC	0.622		NaN											0	0	0	0.016522	0	20	139									
LRRC3	81543	broad.mit.edu	37	21	45876889	45876889	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:45876889C>G	uc002zfa.2	+	2	655	c.362C>G	c.(361-363)TCT>TGT	p.S121C		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	121	LRR 3.					integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		CTGGACCTGTCTTACAACCGC	0.672		NaN											0	0	0	0.014323	0	19	60									
KRTAP10-10	353333	broad.mit.edu	37	21	46058039	46058039	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:46058039C>T	uc002zfq.2	+	1	767	c.705C>T	c.(703-705)TGC>TGT	p.C235C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	235						keratin filament					0						GCCCCGTGTGCTCCCGCCCTG	0.697		NaN											0	0	0	0.01441	0	61	178									
HIRA	7290	broad.mit.edu	37	22	19384471	19384471	+	Splice_Site	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:19384471C>T	uc002zpf.1	-	7	714	c.494_splice	c.e7-1	p.E165_splice	HIRA_uc011agx.1_Splice_Site_p.E31_splice|HIRA_uc010grn.1_Splice_Site_p.E165_splice|HIRA_uc010gro.1_Splice_Site_p.E121_splice|HIRA_uc010grp.2_Splice_Site	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective						chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GCTAGAATTTCTGTGAAGAAA	0.483		NaN											0	0	0	0.016723	0	13	64									
ARVCF	421	broad.mit.edu	37	22	19967410	19967410	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:19967410G>A	uc002zqz.2	-	6	1523	c.1252C>T	c.(1252-1254)CGC>TGC	p.R418C	ARVCF_uc002zqy.2_5'Flank	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	418	ARM 2.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					CAGGCCCGGCGCCGCACCTCA	0.687		NaN											0	0	0	0.001168	0	5	14									
CABIN1	23523	broad.mit.edu	37	22	24439456	24439456	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:24439456G>A	uc002zzi.1	+	6	563	c.436G>A	c.(436-438)GCT>ACT	p.A146T	CABIN1_uc002zzj.1_Missense_Mutation_p.A146T|CABIN1_uc002zzl.1_Missense_Mutation_p.A146T|CABIN1_uc010guk.1_Missense_Mutation_p.A101T|CABIN1_uc002zzk.1_Missense_Mutation_p.A101T	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	146	TPR 3.				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GGCTCGCCATGCTTTTGAGGA	0.537		NaN											0	0	0	0.014323	0	22	83									
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:29091841G>A	uc003adu.1	-	11	1188	c.1116C>T	c.(1114-1116)TCC>TCT	p.S372S	CHEK2_uc003ads.1_Silent_p.S151S|CHEK2_uc010gvh.1_Silent_p.S281S|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Silent_p.S415S|CHEK2_uc003adv.1_Silent_p.S343S|CHEK2_uc003adw.1_Silent_p.S372S|CHEK2_uc003adx.1_Silent_p.S151S|CHEK2_uc003ady.1_Silent_p.S372S|CHEK2_uc003adz.1_Silent_p.S176S	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	372	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(1)		central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCAAAATCTTGGAGTGCCCAA	0.413		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.006122	0	8	55									
PATZ1	23598	broad.mit.edu	37	22	31731850	31731850	+	Splice_Site	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:31731850C>G	uc003akq.2	-	3	1997	c.1336_splice	c.e3-1	p.T446_splice	PATZ1_uc003akp.2_Splice_Site_p.T446_splice|PATZ1_uc003akr.2_Splice_Site_p.T446_splice	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1						negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CATTGCAGGTCTGAAGGCAGA	0.552		NaN											0	0	0	0.009096	0	4	76									
L3MBTL2	83746	broad.mit.edu	37	22	41625593	41625593	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:41625593G>A	uc003azo.2	+	16	1992	c.1938G>A	c.(1936-1938)AAG>AAA	p.K646K	L3MBTL2_uc003azn.2_RNA|CHADL_uc003azq.3_3'UTR|CHADL_uc010gyj.2_3'UTR	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	646					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						AGGGGTCCAAGAAGCCCCTGC	0.557		NaN											0	0	0	0.020292	0	15	40									
PARVB	29780	broad.mit.edu	37	22	44514968	44514968	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:44514968G>A	uc003ben.2	+	4	376	c.324G>A	c.(322-324)GTG>GTA	p.V108V	PARVB_uc003bem.2_Silent_p.V141V|PARVB_uc010gzn.2_Silent_p.V56V|PARVB_uc003beo.2_Silent_p.V71V	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	108	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				GGATCATTGTGAAGCAGCTGG	0.587		NaN											0	0	0	0.01441	0	48	149									
FBLN1	2192	broad.mit.edu	37	22	45970446	45970446	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:45970446G>A	uc003bgj.1	+	15	1900	c.1753G>A	c.(1753-1755)GAT>AAT	p.D585N		NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	585					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCGCCCCAACGATGTCACATG	0.627		NaN											0	0	0	0.013537	0	12	47									
PKDREJ	10343	broad.mit.edu	37	22	46655230	46655230	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:46655230C>G	uc003bhh.2	-	1	3990	c.3990G>C	c.(3988-3990)CAG>CAC	p.Q1330H		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1330	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAAGCCATTTCTGGCATATGA	0.418		NaN											0	0	0	0.01441	0	51	83									
ZBED4	9889	broad.mit.edu	37	22	50277651	50277651	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:50277651C>A	uc003bix.2	+	2	811	c.341C>A	c.(340-342)TCC>TAC	p.S114Y		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	114						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AACATGAGCTCCAGGAAGAAG	0.532		NaN											1	0	9.39395e-14	0.00632	1.28991e-13	26	67									
PLXNB2	23654	broad.mit.edu	37	22	50722117	50722117	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:50722117C>A	uc003bkv.3	-	15	2590	c.2484G>T	c.(2482-2484)TTG>TTT	p.L828F	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	828	Extracellular (Potential).|IPT/TIG 1.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTTGGACGCCCAAATTGGACC	0.647		NaN											1	0	3.07112e-06	0.010729	4.04274e-06	12	34									
ODF3B	440836	broad.mit.edu	37	22	50969699	50969699	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:50969699C>G	uc003bmh.2	-	4	476	c.339G>C	c.(337-339)GGG>GGC	p.G113G	TYMP_uc003bmb.3_5'Flank|TYMP_uc003bmc.3_5'Flank|TYMP_uc003bmd.3_5'Flank|TYMP_uc010hbd.2_5'Flank|TYMP_uc003bme.3_5'Flank|TYMP_uc003bmf.3_5'Flank|TYMP_uc011arz.1_5'Flank|ODF3B_uc003bmg.2_Missense_Mutation_p.E90Q	NM_001014440	NP_001014440	A8MYP8	ODF3B_HUMAN	outer dense fiber of sperm tails 3B	113											0						ACGTCGCGTTCCCCGCTCGCT	0.677		NaN											0	0	0	0.016723	0	12	40									
CHL1	10752	broad.mit.edu	37	3	424356	424356	+	Splice_Site	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:424356T>A	uc003bou.2	+	17	2399	c.2128_splice	c.e17+2	p.A710_splice	CHL1_uc003bot.2_Splice_Site_p.A726_splice|CHL1_uc003bow.1_Splice_Site_p.A710_splice|CHL1_uc011asi.1_Splice_Site_p.A726_splice|uc003box.1_RNA	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CACCAGCAGGTATGCAGGTTC	0.413		NaN											0	0	0	0.00308	0	7	14									
ITPR1	3708	broad.mit.edu	37	3	4715070	4715070	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:4715070G>A	uc003bqa.2	+	21	2803	c.2455G>A	c.(2455-2457)GAC>AAC	p.D819N	ITPR1_uc010hca.1_Missense_Mutation_p.D804N|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.D804N	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	819	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CGCCATTGACGAGTGAGCCTG	0.498		NaN											0	0	0	0.010818	0	27	141									
BRPF1	7862	broad.mit.edu	37	3	9783835	9783835	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:9783835G>A	uc003bse.2	+	6	2380	c.1981G>A	c.(1981-1983)GAG>AAG	p.E661K	BRPF1_uc003bsf.2_Missense_Mutation_p.E661K|BRPF1_uc003bsg.2_Missense_Mutation_p.E661K|BRPF1_uc011ati.1_Missense_Mutation_p.E661K	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	661	Required for RUNX1 and RUNX2 transcriptional activation.|Interaction with MEAF6 and ING5.|Bromo.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					CCCTCTGTCTGAGGTAACCGA	0.557		NaN											0	0	0	0.014323	0	21	89									
JAGN1	84522	broad.mit.edu	37	3	9934620	9934620	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:9934620C>G	uc003btt.3	+	2	247	c.111C>G	c.(109-111)ATC>ATG	p.I37M	CIDEC_uc003bto.2_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1	37	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(1)	1	Medulloblastoma(99;0.227)					AGTATGAAATCAAGAAGCTGA	0.383		NaN											0	0	0	0.014758	0	5	86									
RPL15	6138	broad.mit.edu	37	3	23959373	23959373	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:23959373A>G	uc003ccn.2	+	2	59	c.23A>G	c.(22-24)CAG>CGG	p.Q8R	NKIRAS1_uc003cck.2_Intron|NKIRAS1_uc003ccj.2_5'Flank|NKIRAS1_uc003ccl.2_5'Flank|NKIRAS1_uc003ccm.2_5'Flank|RPL15_uc011awi.1_Missense_Mutation_p.Q8R|RPL15_uc011awj.1_Missense_Mutation_p.Q8R|RPL15_uc003cco.2_Missense_Mutation_p.Q8R|RPL15_uc003ccp.2_Missense_Mutation_p.Q8R|RPL15_uc003ccq.2_Missense_Mutation_p.Q8R|RPL15_uc003ccr.2_Missense_Mutation_p.Q8R	NM_002948	NP_002939	P61313	RL15_HUMAN	ribosomal protein L15	8					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			ovary(1)	1						AAGTACATCCAGGAGCTATGG	0.493		NaN											0	0	0	0.007291	0	25	46									
OXSM	54995	broad.mit.edu	37	3	25832554	25832554	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:25832554C>A	uc003cdn.2	+	2	150	c.43C>A	c.(43-45)CGT>AGT	p.R15S	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_5'UTR|OXSM_uc010hfh.2_Missense_Mutation_p.R15S	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	15					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						TACAAGCACTCGTCTTCTATG	0.388		NaN											1	0	2.89027e-11	0.014323	3.92963e-11	24	60									
SLC4A7	9497	broad.mit.edu	37	3	27446455	27446455	+	Splice_Site	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:27446455C>G	uc003cdv.2	-	14	1986	c.1915_splice	c.e14-1	p.S639_splice	SLC4A7_uc011awu.1_Splice_Site|SLC4A7_uc011awv.1_Splice_Site|SLC4A7_uc003cdu.3_Splice_Site_p.S520_splice|SLC4A7_uc011aww.1_Splice_Site_p.S648_splice|SLC4A7_uc011awx.1_Splice_Site_p.S635_splice|SLC4A7_uc011awy.1_Splice_Site_p.S631_splice|SLC4A7_uc011awz.1_Splice_Site|SLC4A7_uc011axa.1_Splice_Site_p.S520_splice|SLC4A7_uc011axb.1_Splice_Site_p.S635_splice|SLC4A7_uc010hfl.2_Splice_Site_p.S189_splice|SLC4A7_uc003cdw.2_Splice_Site_p.S515_splice	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate							apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CTATTGCACTCTGTTTAAGGA	0.353		NaN											0	0	0	0.008291	0	9	29									
ZNF620	253639	broad.mit.edu	37	3	40553923	40553923	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:40553923C>G	uc003ckk.2	+	4	331	c.182C>G	c.(181-183)TCC>TGC	p.S61C	ZNF620_uc003ckl.2_Intron	NM_175888	NP_787084	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		GTTCTGGTCTCCCAGCTGGAG	0.572		NaN											0	0	0	0.004656	0	25	12									
ULK4	54986	broad.mit.edu	37	3	41942279	41942280	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:41942279_41942280TC>AA	uc003ckv.3	-	13	1425_1426	c.1224_1225GA>TT	c.(1222-1227)CAGATG>CATTTG	p.408_409QM>HL	ULK4_uc003ckw.2_Missense_Mutation_p.408_409QM>HL|ULK4_uc003ckx.1_Missense_Mutation_p.408_409QM>HL	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	408_409							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGCTCTCTCATCTGGGATTCCA	0.411		NaN											0	0	0	0.004672	0	50	179									
ZNF445	353274	broad.mit.edu	37	3	44488486	44488486	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:44488486C>T	uc003cnf.2	-	8	3025	c.2677G>A	c.(2677-2679)GAG>AAG	p.E893K	ZNF445_uc011azv.1_Missense_Mutation_p.E881K|ZNF445_uc011azw.1_Missense_Mutation_p.E893K	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	893					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		AAAGGTCTCTCTGTAGAGTGG	0.453		NaN											0	0	0	0.007291	0	27	95									
ZNF502	91392	broad.mit.edu	37	3	44763893	44763893	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:44763893C>T	uc011baa.1	+	4	1839	c.1584C>T	c.(1582-1584)TTC>TTT	p.F528F	ZNF502_uc003cns.2_Silent_p.F528F|ZNF502_uc011bab.1_Silent_p.F528F|ZNF502_uc003cnt.2_Silent_p.F528F	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	528	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		GAAAGTTCTTCAGACATAGTT	0.413		NaN											0	0	0	0.004482	0	9	41									
DHX30	22907	broad.mit.edu	37	3	47887268	47887268	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:47887268G>T	uc003cru.2	+	10	1444	c.1018G>T	c.(1018-1020)GAG>TAG	p.E340*	DHX30_uc003crt.2_Nonsense_Mutation_p.E301*|DHX30_uc010hjr.1_Nonsense_Mutation_p.E368*	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	340						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TGAGCTGGGTGAGACCCAGCG	0.597		NaN											1	0	6.05902e-23	0.017118	8.50317e-23	35	26									
COL7A1	1294	broad.mit.edu	37	3	48612135	48612135	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:48612135C>A	uc003ctz.2	-	77	6369	c.6368G>T	c.(6367-6369)GGT>GTT	p.G2123V		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2123	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACCTTGGTCACCATTGCTGCC	0.597		NaN											1	0	2.17888e-05	0.006214	2.82776e-05	9	47									
CELSR3	1951	broad.mit.edu	37	3	48698069	48698069	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:48698069C>A	uc003cul.2	-	1	2280	c.1999G>T	c.(1999-2001)GGT>TGT	p.G667C	CELSR3_uc003cuf.1_Missense_Mutation_p.G737C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	667	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACTGAGTGACCCAAGGGAGCA	0.517		NaN											1	0	5.3912e-06	0.006122	7.052e-06	17	42									
USP4	7375	broad.mit.edu	37	3	49363263	49363263	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:49363263G>A	uc003cwq.2	-	4	455	c.376C>T	c.(376-378)CTG>TTG	p.L126L	USP4_uc003cwr.2_Silent_p.L126L	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	126					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		TTGACAAACAGGCCATGCTCC	0.498		NaN											0	0	0	0.007835	0	35	119									
RHOA	387	broad.mit.edu	37	3	49400019	49400019	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:49400019G>C	uc003cwu.2	-	4	594	c.318C>G	c.(316-318)TTC>TTG	p.F106L	RHOA_uc010hku.2_Missense_Mutation_p.F25L	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	106					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	CGTTGGGACAGAAATGCTTGA	0.443		NaN											0	0	0	0.01441	0	46	46									
DOCK3	1795	broad.mit.edu	37	3	51112865	51112865	+	Silent	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:51112865T>C	uc011bds.1	+	7	566	c.543T>C	c.(541-543)TAT>TAC	p.Y181Y		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	181						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGATCTCTATAAGATGGTAA	0.393		NaN											0	0	0	0.00308	0	8	0									
COL8A1	1295	broad.mit.edu	37	3	99513764	99513764	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:99513764G>A	uc003dtg.1	+	5	1264	c.1019G>A	c.(1018-1020)GGG>GAG	p.G340E	COL8A1_uc003dth.1_Missense_Mutation_p.G340E|COL8A1_uc003dti.1_Missense_Mutation_p.G341E	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	340	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						GGACTGCCAGGGCTACCAGGA	0.627		NaN											0	0	0	0.009096	0	4	62									
GPR128	84873	broad.mit.edu	37	3	100362453	100362453	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:100362453C>G	uc003duc.2	+	8	1190	c.922C>G	c.(922-924)CAG>GAG	p.Q308E	GPR128_uc011bhc.1_Intron	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	308	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GACTGAGCTTCAGGTCTTGCT	0.363		NaN											0	0	0	0.013114	0	45	28									
SIDT1	54847	broad.mit.edu	37	3	113327035	113327035	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:113327035G>T	uc003eak.2	+	16	2224	c.1573G>T	c.(1573-1575)GCC>TCC	p.A525S	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.A525S|SIDT1_uc011big.1_Missense_Mutation_p.A278S|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	525	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						CCATCGGAGAGCCCTGGAAGC	0.542		NaN											1	0	1.64293e-13	0.01892	2.25223e-13	26	125									
NR1I2	8856	broad.mit.edu	37	3	119535943	119535943	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:119535943C>A	uc003edj.2	+	9	3028	c.1189C>A	c.(1189-1191)CTC>ATC	p.L397I	NR1I2_uc003edi.2_Missense_Mutation_p.L360I|NR1I2_uc003edk.2_Missense_Mutation_p.L436I|NR1I2_uc003edl.2_Missense_Mutation_p.L285I	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	397	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CATGGCTATGCTCACCGAGCT	0.592		NaN											1	0	3.05275e-18	0.013114	4.25534e-18	44	91									
POLQ	10721	broad.mit.edu	37	3	121209029	121209029	+	Missense_Mutation	SNP	C	C	T	rs149007312	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:121209029C>T	uc003eee.3	-	16	2878	c.2749G>A	c.(2749-2751)GAA>AAA	p.E917K	POLQ_uc003eed.2_Missense_Mutation_p.E89K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	917					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TCCTTTACTTCGGACTCACTA	0.338		NaN						DNA_polymerases_(catalytic_subunits)					0	0	0	0.007835	0	42	46									
ZNF148	7707	broad.mit.edu	37	3	124951899	124951899	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:124951899C>G	uc003ehx.3	-	9	2157	c.1671G>C	c.(1669-1671)GAG>GAC	p.E557D	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Missense_Mutation_p.E557D|ZNF148_uc010hsa.2_Missense_Mutation_p.E557D|ZNF148_uc003eia.3_Missense_Mutation_p.E557D|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	557					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TGAAGGATATCTCATGCTGTC	0.398		NaN											0	0	0	0.004482	0	8	44									
C3orf22	152065	broad.mit.edu	37	3	126272147	126272147	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:126272147G>A	uc003ejb.2	-	2	416	c.87C>T	c.(85-87)TAC>TAT	p.Y29Y		NM_152533	NP_689746	Q8N5N4	CC022_HUMAN	hypothetical protein LOC152065	29											0				GBM - Glioblastoma multiforme(114;0.147)		TCCCGCACCTGTACGGAAACT	0.567		NaN											0	0	0	0.003163	0	15	638									
NEK11	79858	broad.mit.edu	37	3	130828671	130828671	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:130828671C>T	uc003eny.2	+	5	687	c.361C>T	c.(361-363)CAG>TAG	p.Q121*	NEK11_uc003enx.2_Nonsense_Mutation_p.Q121*|NEK11_uc003eoa.2_Nonsense_Mutation_p.Q121*|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_5'UTR|NEK11_uc011bll.1_Nonsense_Mutation_p.Q121*|NEK11_uc003enw.1_Nonsense_Mutation_p.Q121*|NEK11_uc011blm.1_Nonsense_Mutation_p.Q121*|NEK11_uc010hto.1_5'UTR	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	121	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						CGATAAAATTCAGGAATATAA	0.338		NaN											0	0	0	0.013726	0	31	24									
PLCH1	23007	broad.mit.edu	37	3	155203300	155203300	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:155203300T>A	uc011bok.1	-	22	3120	c.2843A>T	c.(2842-2844)GAG>GTG	p.E948V	PLCH1_uc011boj.1_Missense_Mutation_p.E948V|PLCH1_uc011bol.1_Missense_Mutation_p.E910V	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	948					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCTTGTGGCCTCGGACACAGA	0.522		NaN											0	0	0	0.013114	0	43	132									
SI	6476	broad.mit.edu	37	3	164750379	164750379	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:164750379T>A	uc003fei.2	-	24	2729	c.2667A>T	c.(2665-2667)GAA>GAT	p.E889D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	889	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCACTCTAACTTCTGTAACAC	0.348		NaN								HNSCC(35;0.089)			0	0	0	0.010729	0	10	8									
SERPINI2	5276	broad.mit.edu	37	3	167183097	167183097	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:167183097C>G	uc003fer.1	-	4	821	c.763G>C	c.(763-765)GAA>CAA	p.E255Q	SERPINI2_uc003fes.1_Missense_Mutation_p.E265Q|SERPINI2_uc003fet.1_Missense_Mutation_p.E255Q	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	255					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TCCATACCTTCTGCAGGAAGT	0.358		NaN											0	0	0	0.010729	0	11	102									
DCUN1D1	54165	broad.mit.edu	37	3	182681826	182681826	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:182681826C>A	uc003fld.1	-	3	281	c.232G>T	c.(232-234)GAG>TAG	p.E78*	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	78	DCUN1.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			ATTTTATTCTCATCTTGAGGG	0.353		NaN											1	0	2.7689e-08	0.001984	3.69782e-08	7	48									
C3orf70	285382	broad.mit.edu	37	3	184801154	184801154	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:184801154C>T	uc003fpd.2	-	2	585	c.394G>A	c.(394-396)GAC>AAC	p.D132N		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	132											0						TGATAGTTGTCAATAAAAAGG	0.468		NaN											0	0	0	0.010504	0	20	113									
ETV5	2119	broad.mit.edu	37	3	185798944	185798944	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:185798944G>C	uc003fpz.2	-	6	500	c.253C>G	c.(253-255)CCA>GCA	p.P85A	ETV5_uc003fpy.2_Missense_Mutation_p.P127A	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	85					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			ATCTTGGTTGGAGGTGGGGCA	0.512		NaN	T	TMPRSS2|SCL45A3	Prostate 								0	0	0	0.01441	0	85	104									
LPP	4026	broad.mit.edu	37	3	188327375	188327375	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:188327375G>A	uc003frs.1	+	6	1102	c.856G>A	c.(856-858)GGG>AGG	p.G286R	LPP_uc011bsg.1_Intron|LPP_uc011bsi.1_Missense_Mutation_p.G286R|LPP_uc003frt.2_Missense_Mutation_p.G286R|LPP_uc011bsj.1_Missense_Mutation_p.G123R	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	286	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GCCGGAGCCTGGGTATGGGTA	0.567		NaN	T	HMGA2|MLL|C12orf9	lipoma|leukemia								0	0	0	0.010729	0	11	96									
PIGG	54872	broad.mit.edu	37	4	494383	494383	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:494383G>A	uc003gak.3	+	2	489	c.353G>A	c.(352-354)CGA>CAA	p.R118Q	PIGG_uc003gaj.3_Missense_Mutation_p.R118Q|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.R118Q|PIGG_uc003gal.3_Missense_Mutation_p.R29Q|ZNF721_uc003gag.2_5'Flank|ZNF721_uc010ibe.2_5'Flank|ZNF721_uc003gah.1_5'Flank|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_5'UTR|PIGG_uc003gam.2_Missense_Mutation_p.R29Q|PIGG_uc003gan.2_Missense_Mutation_p.R29Q	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	118	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						ACTATGCCTCGAATCAAGGTA	0.408		NaN											0	0	0	0.01892	0	23	18									
PDE6B	5158	broad.mit.edu	37	4	628477	628477	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:628477C>T	uc003gap.2	+	2	533	c.480C>T	c.(478-480)TTC>TTT	p.F160F	PDE6B_uc003gao.3_Silent_p.F160F	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	160	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GCCCTCACTTCAGCTCATTTG	0.567		NaN											0	0	0	0.005524	0	35	76									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.013726	0	22	15									
OTOP1	133060	broad.mit.edu	37	4	4199019	4199019	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:4199019C>G	uc003ghp.1	-	5	1572	c.1542G>C	c.(1540-1542)GAG>GAC	p.E514D		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	514					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCTCCTGCTTCTCCTCCTCCT	0.577		NaN											0	0	0	0.014323	0	20	70									
ZBTB49	166793	broad.mit.edu	37	4	4314802	4314802	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:4314802C>G	uc003ghu.2	+	5	1512	c.1337C>G	c.(1336-1338)TCT>TGT	p.S446C	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_Intron|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CGACGGCATTCTGGTGAAAAA	0.413		NaN											0	0	0	0.01892	0	19	47									
EVC2	132884	broad.mit.edu	37	4	5586480	5586480	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:5586480G>C	uc003gij.2	-	17	2981	c.2927C>G	c.(2926-2928)TCC>TGC	p.S976C	EVC2_uc011bwb.1_Missense_Mutation_p.S416C|EVC2_uc003gik.2_Missense_Mutation_p.S896C	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	976						integral to membrane				large_intestine(3)|ovary(2)	5						GGTCACCCGGGACGCCTTCTG	0.607		NaN											0	0	0	0.006122	0	16	35									
TXK	7294	broad.mit.edu	37	4	48106974	48106974	+	Splice_Site	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:48106974T>C	uc003gxx.3	-	6	533	c.447_splice	c.e6-1	p.E149_splice	TXK_uc003gxy.1_Splice_Site_p.E149_splice	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase							cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TGGTACCACCTGTAAAAGCaa	0.274		NaN											0	0	0	0.006214	0	10	19									
LPHN3	23284	broad.mit.edu	37	4	62849142	62849142	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:62849142C>A	uc010ihh.2	+	16	3026	c.2853C>A	c.(2851-2853)TTC>TTA	p.F951L	LPHN3_uc003hcq.3_Missense_Mutation_p.F951L|LPHN3_uc003hct.2_Missense_Mutation_p.F344L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	938	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATTTCTTCTTCTTGGCTGCCT	0.433		NaN											1	0	0.00024832	0.009096	0.000317298	4	16									
COPS4	51138	broad.mit.edu	37	4	83984325	83984325	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:83984325G>A	uc003hoa.2	+	7	951	c.812G>A	c.(811-813)AGG>AAG	p.R271K	COPS4_uc003hob.2_Missense_Mutation_p.R271K|COPS4_uc010ijw.2_Missense_Mutation_p.R271K|COPS4_uc010ijx.2_Missense_Mutation_p.R271K	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	271	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				TATCTAGATAGGATCATCAGA	0.428		NaN											0	0	0	0.007413	0	20	45									
WDFY3	23001	broad.mit.edu	37	4	85634326	85634326	+	Silent	SNP	C	C	A	rs150169644	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:85634326C>A	uc003hpd.2	-	51	8436	c.8028G>T	c.(8026-8028)ACG>ACT	p.T2676T	WDFY3_uc003hpe.1_Silent_p.T287T	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2676						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCTCCACACTCGTGTTTGGTC	0.383		NaN											1	0	1.85257e-25	0.01441	2.60873e-25	59	158									
HSD17B13	345275	broad.mit.edu	37	4	88238286	88238286	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:88238286C>A	uc003hqo.2	-	3	471	c.408G>T	c.(406-408)GAG>GAT	p.E136D	HSD17B13_uc010ikk.2_Missense_Mutation_p.E100D	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	136						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TCTTGGTAATCTCTTCATCCT	0.403		NaN											1	0	0.00400662	0.004007	0.00503412	15	54									
PDHA2	5161	broad.mit.edu	37	4	96761707	96761707	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:96761707C>T	uc003htr.3	+	1	469	c.406C>T	c.(406-408)CTG>TTG	p.L136L		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	136					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TCTCGCAGAGCTGACGGGAAG	0.517		NaN											0	0	0	0.010504	0	20	56									
MANBA	4126	broad.mit.edu	37	4	103571706	103571706	+	Missense_Mutation	SNP	G	G	C	rs141009346		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:103571706G>C	uc003hwg.2	-	13	1957	c.1857C>G	c.(1855-1857)ATC>ATG	p.I619M	MANBA_uc011ces.1_Missense_Mutation_p.I562M	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	619					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GAGTAAGGTAGATGGTATCTT	0.363		NaN											0	0	0	0.00308	0	7	32									
KIAA1109	84162	broad.mit.edu	37	4	123117944	123117944	+	Silent	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:123117944A>C	uc003ieh.2	+	10	1252	c.1207A>C	c.(1207-1209)AGG>CGG	p.R403R	KIAA1109_uc003iei.1_Silent_p.R157R|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	403					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TACCAAAAATAGGGtaattat	0.284		NaN											0	0	0	0.010729	0	12	27									
PDGFC	56034	broad.mit.edu	37	4	157684305	157684305	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:157684305G>C	uc003iph.1	-	6	1466	c.975C>G	c.(973-975)ACC>ACG	p.T325T	PDGFC_uc003ipi.1_Silent_p.T162T|PDGFC_uc011cis.1_Silent_p.T162T|PDGFC_uc011cir.1_Silent_p.T169T	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	325					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		GGGCCACGTCGGTGAGTGATT	0.527		NaN											0	0	0	0.010729	0	10	27									
TLL1	7092	broad.mit.edu	37	4	167020652	167020652	+	Silent	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:167020652G>T	uc003irh.1	+	20	3527	c.2880G>T	c.(2878-2880)GTG>GTT	p.V960V	TLL1_uc011cjn.1_Silent_p.V983V|TLL1_uc011cjo.1_Silent_p.V784V	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	960	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CAACAGCTGTGGGGCTTGGTC	0.433		NaN											1	0	4.36969e-10	0.016723	5.90229e-10	13	37									
CBR4	84869	broad.mit.edu	37	4	169931103	169931103	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:169931103G>A	uc003iry.2	-	1	320	c.138C>T	c.(136-138)CTC>CTT	p.L46L	CBR4_uc011cjy.1_RNA|CBR4_uc003irz.1_Silent_p.L46L	NM_032783	NP_116172	Q8N4T8	CBR4_HUMAN	carbonic reductase 4	46					fatty acid biosynthetic process|protein homotetramerization	mitochondrial matrix	NADPH binding|NADPH dehydrogenase (quinone) activity|protein binding|quinone binding				0		Prostate(90;0.00263)|Renal(120;0.0183)|Melanoma(52;0.123)		GBM - Glioblastoma multiforme(119;0.0321)		ACCTACCGCCGAGGTCACCGG	0.587		NaN									OREG0016397	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	10	26									
VEGFC	7424	broad.mit.edu	37	4	177608517	177608517	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:177608517G>C	uc003ius.1	-	6	1399	c.969C>G	c.(967-969)CTC>CTG	p.L323L		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	323	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GGCTGGGGAAGAGTTTGTTTT	0.502		NaN											0	0	0	0.010818	0	28	75									
SLC12A7	10723	broad.mit.edu	37	5	1087072	1087072	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:1087072C>T	uc003jbu.2	-	6	687	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	207	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ACGTCGTGCCCAGGTAGAAGC	0.587		NaN											0	0	0	0.007413	0	19	82									
IRX2	153572	broad.mit.edu	37	5	2748596	2748596	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:2748596C>A	uc003jda.2	-	3	1468	c.1226G>T	c.(1225-1227)CGG>CTG	p.R409L	IRX2_uc003jdb.2_Missense_Mutation_p.R409L	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	409						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		AGAGTTGTACCGCAGGAGACC	0.716		NaN											1	0	8.16721e-17	0.010818	1.13274e-16	31	67									
ADAMTS16	170690	broad.mit.edu	37	5	5190099	5190099	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:5190099A>T	uc003jdl.2	+	7	1201	c.1063A>T	c.(1063-1065)AGT>TGT	p.S355C	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S355C|ADAMTS16_uc003jdj.1_Missense_Mutation_p.S355C	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	355	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ACTGGTGATAAGTCACCACGC	0.473		NaN											0	0	0	0.013537	0	11	110									
ADCY2	108	broad.mit.edu	37	5	7695884	7695884	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:7695884G>A	uc003jdz.1	+	6	956	c.889G>A	c.(889-891)GTT>ATT	p.V297I	ADCY2_uc011cmo.1_Missense_Mutation_p.V117I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	297	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGCTGACATCGTTGGCTTTAC	0.408		NaN											0	0	0	0.015359	0	34	57									
FASTKD3	79072	broad.mit.edu	37	5	7867275	7867275	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:7867275G>C	uc003jeb.2	-	2	1059	c.922C>G	c.(922-924)CAA>GAA	p.Q308E	FASTKD3_uc011cmp.1_Missense_Mutation_p.Q10E|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	308					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GCTTGACTTTGATCAAGAACC	0.393		NaN											0	0	0	0.005443	0	25	204									
CTNND2	1501	broad.mit.edu	37	5	11098851	11098851	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:11098851C>A	uc003jfa.1	-	15	2618	c.2473G>T	c.(2473-2475)GTA>TTA	p.V825L	CTNND2_uc010itt.2_Missense_Mutation_p.V734L|CTNND2_uc011cmy.1_Missense_Mutation_p.V488L|CTNND2_uc011cmz.1_Missense_Mutation_p.V392L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.V392L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	825					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AGAGGTCCTACTCCATCCCAC	0.468		NaN											1	0	3.86212e-05	0.008291	4.98105e-05	9	83									
TRIO	7204	broad.mit.edu	37	5	14381300	14381300	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:14381300C>G	uc003jff.2	+	21	3515	c.3509C>G	c.(3508-3510)TCC>TGC	p.S1170C	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.S1121C|TRIO_uc003jfh.1_Missense_Mutation_p.S819C	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1170	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCCACGGGCTCCAGTATACAG	0.512		NaN											0	0	0	0.01441	0	70	130									
TRIO	7204	broad.mit.edu	37	5	14387928	14387928	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:14387928G>C	uc003jff.2	+	23	3859	c.3853G>C	c.(3853-3855)GAG>CAG	p.E1285Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E1236Q|TRIO_uc003jfh.1_Missense_Mutation_p.E934Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1285					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					ACTTAATGAAGAGAAGCGGAA	0.443		NaN											0	0	0	0.016723	0	13	106									
MARCH11	441061	broad.mit.edu	37	5	16177939	16177939	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:16177939G>T	uc003jfo.2	-	2	802	c.589C>A	c.(589-591)CAG>AAG	p.Q197K	uc003jfp.2_5'Flank	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	197	RING-CH-type.					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AGGCACAGCTGATGTGTATAC	0.423		NaN											1	0	2.32078e-09	0.003163	3.11444e-09	14	128									
CDH12	1010	broad.mit.edu	37	5	21802336	21802336	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:21802336A>T	uc010iuc.2	-	7	1654	c.1196T>A	c.(1195-1197)GTA>GAA	p.V399E	CDH12_uc011cno.1_Missense_Mutation_p.V359E|CDH12_uc003jgk.2_Missense_Mutation_p.V399E	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	399	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GATGGTCCCTACCGGAGTGTC	0.478		NaN								HNSCC(59;0.17)			0	0	0	0.008871	0	19	17									
PRDM9	56979	broad.mit.edu	37	5	23526574	23526574	+	Silent	SNP	G	G	A	rs112001060		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:23526574G>A	uc003jgo.2	+	11	1559	c.1377G>A	c.(1375-1377)AGG>AGA	p.R459R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	459					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCAAAGAAAGGTCCAAACTCT	0.468		NaN								HNSCC(3;0.000094)			0	0	0	0.005443	0	29	17									
MTMR12	54545	broad.mit.edu	37	5	32239280	32239280	+	Splice_Site	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:32239280C>G	uc003jhq.2	-	13	1342	c.1172_splice	c.e13-1	p.E391_splice	MTMR12_uc010iuk.2_Splice_Site_p.E391_splice|MTMR12_uc010iul.2_Splice_Site_p.E391_splice	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12							cytoplasm	phosphatase activity			ovary(1)	1						GCATTCTCCTCTAGGAGAGGC	0.483		NaN											0	0	0	0.003163	0	14	90									
OSMR	9180	broad.mit.edu	37	5	38917668	38917668	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:38917668G>A	uc003jln.1	+	10	1673	c.1306G>A	c.(1306-1308)GTC>ATC	p.V436I	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	436	Fibronectin type-III 2.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GGCCCCTGATGTCTGGAGAAT	0.408		NaN											0	0	0	0.012319	0	22	174									
PTGER4	5734	broad.mit.edu	37	5	40692210	40692210	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:40692210C>G	uc003jlz.2	+	3	1789	c.1197C>G	c.(1195-1197)CTC>CTG	p.L399L		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	399	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						TGCCAGACCTCTCACTGCCAG	0.572		NaN											0	0	0	0.016723	0	12	124									
CARD6	84674	broad.mit.edu	37	5	40843437	40843437	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:40843437G>C	uc003jmg.2	+	2	542	c.467G>C	c.(466-468)AGG>ACG	p.R156T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	156					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						ACTAGTTATAGGGAAACAGCT	0.418		NaN											0	0	0	0.009096	0	4	73									
HEXB	3074	broad.mit.edu	37	5	74014165	74014165	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:74014165G>C	uc003kdf.3	+	10	1336	c.1219G>C	c.(1219-1221)GAG>CAG	p.E407Q	HEXB_uc003kdd.2_Missense_Mutation_p.E182Q|HEXB_uc010izh.2_RNA|HEXB_uc003kdg.1_RNA|HEXB_uc010izi.1_RNA	NM_000521	NP_000512	P07686	HEXB_HUMAN	hexosaminidase B preproprotein	407					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		TGTCTGGCAGGAGGTTTTTGA	0.328		NaN											0	0	0	0.020292	0	11	44									
GFM2	84340	broad.mit.edu	37	5	74054712	74054712	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:74054712C>T	uc003kdh.1	-	5	570	c.266G>A	c.(265-267)AGA>AAA	p.R89K	GFM2_uc003kdi.1_Missense_Mutation_p.R89K|GFM2_uc010izj.1_Missense_Mutation_p.R121K|GFM2_uc010izk.1_RNA|GFM2_uc003kdj.1_Missense_Mutation_p.R89K|GFM2_uc010izl.1_Missense_Mutation_p.R89K	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	89					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GTACAATATTCTTTCTGTGGT	0.358		NaN											0	0	0	0.009096	0	3	32									
POC5	134359	broad.mit.edu	37	5	74990490	74990490	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:74990490C>T	uc003keh.3	-	6	877	c.680G>A	c.(679-681)AGA>AAA	p.R227K	POC5_uc010izu.2_Missense_Mutation_p.R110K|POC5_uc003keg.3_Missense_Mutation_p.R202K	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	227					cell cycle	centriole				lung(1)	1						CTCATCTTTTCTCCCAATGGA	0.294		NaN											0	0	0	0.014758	0	5	25									
GPR98	84059	broad.mit.edu	37	5	90281315	90281315	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:90281315T>A	uc003kju.2	+	85	18224	c.18128T>A	c.(18127-18129)ATC>AAC	p.I6043N	GPR98_uc003kjt.2_Missense_Mutation_p.I3749N|GPR98_uc003kjw.2_Missense_Mutation_p.I1704N|GPR98_uc003kjx.2_Missense_Mutation_p.I71N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	6043	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCACAGATCTATGGACTC	0.423		NaN											0	0	0	0.004007	0	14	16									
TRIM36	55521	broad.mit.edu	37	5	114473227	114473227	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:114473227C>G	uc003kqs.2	-	6	1463	c.954G>C	c.(952-954)TTG>TTC	p.L318F	TRIM36_uc011cwc.1_Missense_Mutation_p.L306F|TRIM36_uc003kqt.2_Missense_Mutation_p.L163F	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	318	Potential.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		CAATTGCTTTCAAAACAGATG	0.368		NaN											0	0	0	0.00623	0	40	76									
LRRTM2	26045	broad.mit.edu	37	5	138209627	138209627	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:138209627C>T	uc011cyz.1	-	2	1080	c.623G>A	c.(622-624)AGA>AAA	p.R208K	CTNNA1_uc003ldh.2_Intron|CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Intron|LRRTM2_uc010jez.2_Intron|LRRTM2_uc011cza.1_Missense_Mutation_p.R74K|CTNNA1_uc003ldl.2_5'Flank	NM_015564	NP_056379	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	208	Extracellular (Potential).|LRR 7.					cell junction|integral to membrane|postsynaptic membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTGAAGCTCTCTCAGTTTAAT	0.448		NaN											0	0	0	0.01441	0	159	17									
DND1	373863	broad.mit.edu	37	5	140052881	140052881	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140052881C>T	uc003lgt.2	-	2	161	c.117G>A	c.(115-117)CAG>CAA	p.Q39Q		NM_194249	NP_919225	Q8IYX4	DND1_HUMAN	dead end homolog 1	39					multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATACTTCCTCTGCCCGTTCA	0.667		NaN											0	0	0	0.007291	0	25	71									
PCDHA2	56146	broad.mit.edu	37	5	140176232	140176232	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140176232C>T	uc003lhd.2	+	1	1789	c.1683C>T	c.(1681-1683)AAC>AAT	p.N561N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.N561N|PCDHA2_uc011czy.1_Silent_p.N561N	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	561	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGACAACGCGCCGGCAC	0.692		NaN											0	0	0	0.00632	0	25	71									
PCDHA4	56144	broad.mit.edu	37	5	140187223	140187223	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140187223C>G	uc003lhi.2	+	1	552	c.451C>G	c.(451-453)CGG>GGG	p.R151G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.R151G|PCDHA4_uc011daa.1_Missense_Mutation_p.R151G	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	151	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTGACTCTCGGTTTCCACT	0.542		NaN											0	0	0	0.014758	0	5	87									
PCDHA9	9752	broad.mit.edu	37	5	140229336	140229336	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140229336C>T	uc003lhu.2	+	1	1980	c.1256C>T	c.(1255-1257)TCC>TTC	p.S419F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.S419F	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	419	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAGTGTGTCCGCCTACGAG	0.637		NaN											0	0	0	0.012213	0	33	101									
PCDHAC2	56134	broad.mit.edu	37	5	140348186	140348186	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140348186C>A	uc003lii.2	+	1	2075	c.1835C>A	c.(1834-1836)TCA>TAA	p.S612*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Nonsense_Mutation_p.S612*	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	612	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTATGGACTCAGACTCTGGG	0.507		NaN											1	0	2.35188e-11	0.006122	3.20289e-11	17	31									
PCDHGA10	56106	broad.mit.edu	37	5	140793480	140793480	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140793480C>T	uc003lkl.1	+	1	738	c.738C>T	c.(736-738)TTC>TTT	p.F246F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.F246F	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	246	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCGGTCTTCACCTTGCCAG	0.582		NaN											0	0	0	0.008291	0	9	34									
JAKMIP2	9832	broad.mit.edu	37	5	147015815	147015815	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:147015815G>A	uc003loq.1	-	12	2029	c.1647C>T	c.(1645-1647)TTC>TTT	p.F549F	JAKMIP2_uc011dbx.1_Silent_p.F507F|JAKMIP2_uc003lor.1_Intron|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Silent_p.F549F	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	549	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCTTAATGAAAAGTTGTT	0.468		NaN											0	0	0	0.001984	0	6	14									
FAM71B	153745	broad.mit.edu	37	5	156589870	156589870	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:156589870G>T	uc003lwn.2	-	2	1506	c.1406C>A	c.(1405-1407)TCC>TAC	p.S469Y		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	469						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCCAGATGCGGACCGGTGGGA	0.532		NaN											1	0	2.27054e-47	0.01441	3.22472e-47	130	22									
ODZ2	57451	broad.mit.edu	37	5	167625892	167625892	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:167625892A>T	uc010jjd.2	+	16	2908	c.2908A>T	c.(2908-2910)ACT>TCT	p.T970S	ODZ2_uc003lzr.3_Missense_Mutation_p.T747S|ODZ2_uc003lzt.3_Missense_Mutation_p.T343S|ODZ2_uc010jje.2_Missense_Mutation_p.T241S	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGCTTCCTTGACTCTACACTT	0.547		NaN											0	0	0	0.01441	0	45	26									
CDHR2	54825	broad.mit.edu	37	5	176008383	176008383	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176008383C>G	uc003mem.1	+	17	1924	c.1858C>G	c.(1858-1860)CTG>GTG	p.L620V	CDHR2_uc003men.1_Missense_Mutation_p.L620V	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	620	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CAACAGCCGTCTGCTCTTCAA	0.632		NaN											0	0	0	0.019004	0	34	9									
UNC5A	90249	broad.mit.edu	37	5	176304243	176304243	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176304243G>A	uc003mey.2	+	9	1621	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	477	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAAGATCTATGAGATCTACCT	0.642		NaN											0	0	0	0.021523	0	23	45									
UNC5A	90249	broad.mit.edu	37	5	176304245	176304245	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176304245G>A	uc003mey.2	+	9	1623	c.1431G>A	c.(1429-1431)GAG>GAA	p.E477E		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	477	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGATCTATGAGATCTACCTCA	0.642		NaN											0	0	0	0.021523	0	24	42									
FAM193B	54540	broad.mit.edu	37	5	176952002	176952002	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176952002C>G	uc003mhs.3	-	8	2970	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	FAM193B_uc003mhr.2_5'UTR|FAM193B_uc003mht.2_Missense_Mutation_p.E120Q|FAM193B_uc003mhu.2_Missense_Mutation_p.E173Q|FAM193B_uc003mhv.2_Missense_Mutation_p.E120Q|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	494											0						ATGCTGAGCTCACACACACTG	0.572		NaN											0	0	0	0.009096	0	4	91									
FAM153C	653316	broad.mit.edu	37	5	177468711	177468711	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:177468711G>A	uc011dge.1	+	7	352	c.151G>A	c.(151-153)GAG>AAG	p.E51K	FAM153C_uc003mig.1_Missense_Mutation_p.E51K	NM_001079527	NP_001072995			hypothetical protein LOC653316												0	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAAGACCTGGAGGAGCATCT	0.522		NaN											0	0	0	0.01441	0	61	168									
EXOC2	55770	broad.mit.edu	37	6	592509	592509	+	Silent	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:592509G>C	uc003mtd.2	-	11	1286	c.1152C>G	c.(1150-1152)CTC>CTG	p.L384L	EXOC2_uc003mte.2_Silent_p.L384L|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	384					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		AACTGTGCATGAGCTGAAGGA	0.468		NaN											0	0	0	0.007413	0	19	46									
HIST1H4D	8360	broad.mit.edu	37	6	26188994	26188994	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:26188994C>T	uc003ngu.2	-	1	311	c.311G>A	c.(310-312)TGA>TAA	p.*104*		NM_003539	NP_003530	P62805	H4_HUMAN	histone cluster 1, H4d	104					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				GAGGTAAGCTCAGCCGCCGAA	0.537		NaN											0	0	0	0.01892	0	22	69									
BTN3A1	11119	broad.mit.edu	37	6	26413833	26413833	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:26413833C>T	uc003nhv.2	+	10	1823	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Silent_p.F433F|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	485	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TTCATACTTTCCTGGACGTCT	0.463		NaN											0	0	0	0.00632	0	29	127									
BTN3A1	11119	broad.mit.edu	37	6	26413848	26413848	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:26413848C>G	uc003nhv.2	+	10	1838	c.1470C>G	c.(1468-1470)TTC>TTG	p.F490L	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Missense_Mutation_p.F438L|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	490	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACGTCTCCTTCTCTGAGGCTC	0.458		NaN											0	0	0	0.009535	0	32	113									
BAT2	7916	broad.mit.edu	37	6	31600510	31600510	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:31600510C>G	uc003nvb.3	+	16	4309	c.4060C>G	c.(4060-4062)CCT>GCT	p.P1354A	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P1354A	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1354	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TGTGGGAACTCCTGGGGGAGG	0.582		NaN											0	0	0	0.016522	0	24	89									
BAT2	7916	broad.mit.edu	37	6	31600529	31600529	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:31600529G>C	uc003nvb.3	+	16	4328	c.4079G>C	c.(4078-4080)GGA>GCA	p.G1360A	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.G1360A	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1360	4 X 57 AA type A repeats.|Poly-Gly.					cytoplasm|nucleus	protein binding				0						GGTGGAGGTGGAGCCGTACCA	0.592		NaN											0	0	0	0.01441	0	85	49									
RXRB	6257	broad.mit.edu	37	6	33165552	33165552	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:33165552G>A	uc003odb.2	-	4	986	c.807C>T	c.(805-807)GGC>GGT	p.G269G	RXRB_uc003odc.2_Silent_p.G269G|RXRB_uc003odd.2_Silent_p.G173G|RXRB_uc011dqr.1_Silent_p.G79G|RXRB_uc011dqs.1_Silent_p.G152G|RXRB_uc003ode.1_Silent_p.G133G|RXRB_uc011dqt.1_Silent_p.G269G|RXRB_uc011dqu.1_Silent_p.G173G	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	269	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CCCTCTTCATGCCAGTGGCCA	0.577		NaN											0	0	0	0.00308	0	7	64									
DEF6	50619	broad.mit.edu	37	6	35265694	35265694	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:35265694G>C	uc003okk.2	+	1	100	c.61G>C	c.(61-63)GAG>CAG	p.E21Q	DEF6_uc010jvs.2_Missense_Mutation_p.E21Q|DEF6_uc010jvt.2_5'UTR	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	21						cytoplasm|nucleus|plasma membrane					0						GCTGGACGTGGAGAAGAGTGG	0.672		NaN											0	0	0	0.004482	0	8	37									
TULP1	7287	broad.mit.edu	37	6	35471540	35471540	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:35471540G>A	uc003okv.3	-	12	1210	c.1198C>T	c.(1198-1200)CGG>TGG	p.R400W	TULP1_uc003okw.3_Missense_Mutation_p.R347W	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	400			R -> W (in LCA15).		dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						AGCTCCTGCCGAAGGCTTGCC	0.597		NaN											0	0	0	0.014323	0	21	7									
PNPLA1	285848	broad.mit.edu	37	6	36259282	36259282	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:36259282G>A	uc010jwf.2	+	2	391	c.391G>A	c.(391-393)GAG>AAG	p.E131K	PNPLA1_uc003olw.1_Missense_Mutation_p.E36K|PNPLA1_uc010jwe.1_Missense_Mutation_p.E36K	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	131	Patatin.				lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						AACGGACGGGGAGAATGTGGT	0.637		NaN											0	0	0	0.014758	0	5	34									
C6orf129	154467	broad.mit.edu	37	6	37451064	37451064	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:37451064C>T	uc003ont.2	-	4	253	c.192G>A	c.(190-192)GAG>GAA	p.E64E		NM_138493	NP_612502	Q9P0B6	CF129_HUMAN	hypothetical protein LOC154467	64	Potential.					integral to membrane					0						TCAGTTCCTTCTCTGGGAGGA	0.532		NaN											0	0	0	0.001168	0	6	74									
UNC5CL	222643	broad.mit.edu	37	6	41002620	41002620	+	Nonsense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:41002620G>C	uc003opi.2	-	2	283	c.194C>G	c.(193-195)TCA>TGA	p.S65*	UNC5CL_uc010jxe.1_Nonsense_Mutation_p.S65*	NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	65	Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTGCTGCCTTGAGACCTCATT	0.587		NaN											0	0	0	0.01892	0	24	131									
CNPY3	10695	broad.mit.edu	37	6	42902239	42902239	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:42902239A>C	uc003ota.3	+	2	627	c.178A>C	c.(178-180)AAG>CAG	p.K60Q	CNPY3_uc003osy.2_RNA|CNPY3_uc003osz.2_Missense_Mutation_p.K60Q|CNPY3_uc003otc.3_5'UTR|CNPY3_uc003otb.3_Intron	NM_006586	NP_006577	Q9BT09	CNPY3_HUMAN	trinucleotide repeat containing 5 precursor	60	Saposin B-type.				innate immune response	endoplasmic reticulum				ovary(1)	1	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			TGTGGAGCTGAAGTCAGCCTT	0.537		NaN											0	0	0	0.006122	0	19	53									
CUL7	9820	broad.mit.edu	37	6	43006375	43006375	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:43006375T>C	uc003otq.2	-	24	4799	c.4496A>G	c.(4495-4497)AAT>AGT	p.N1499S	CUL7_uc010jyg.2_Missense_Mutation_p.N778S|CUL7_uc011dvb.1_Missense_Mutation_p.N1583S|CUL7_uc010jyh.2_Missense_Mutation_p.N492S|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1499					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AATCGCCTGATTGAGCATGTC	0.587		NaN											0	0	0	0.004656	0	26	89									
COL21A1	81578	broad.mit.edu	37	6	56044893	56044893	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:56044893G>C	uc003pcs.2	-	3	355	c.123C>G	c.(121-123)ATC>ATG	p.I41M	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.I41M|COL21A1_uc003pcu.1_Missense_Mutation_p.I41M	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	41	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGCCATCTAAGATGAAAACTA	0.348		NaN											0	0	0	0.001984	0	6	9									
RIMS1	22999	broad.mit.edu	37	6	72678707	72678707	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:72678707G>A	uc003pga.2	+	2	263	c.186G>A	c.(184-186)GCG>GCA	p.A62A		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	62	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGGACATGGCGAAGCCTGCTG	0.453		NaN											0	0	0	0.01441	0	46	43									
GJB7	375519	broad.mit.edu	37	6	87994088	87994088	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:87994088G>A	uc003plo.2	-	3	889	c.543C>T	c.(541-543)CTC>CTT	p.L181L		NM_198568	NP_940970	Q6PEY0	CXB7_HUMAN	gap junction protein, beta 7, 25kDa	181	Helical; (Potential).				cell communication	connexon complex|integral to membrane					0		all_cancers(76;1.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;7.38e-10)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00323)		BRCA - Breast invasive adenocarcinoma(108;0.0167)		TGACCAAGAAGAGGATGAAGA	0.398		NaN											0	0	0	0.010729	0	12	30									
EPHA7	2045	broad.mit.edu	37	6	93965737	93965737	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:93965737T>C	uc003poe.2	-	13	2432	c.2191A>G	c.(2191-2193)ACA>GCA	p.T731A	EPHA7_uc003pof.2_Missense_Mutation_p.T726A|EPHA7_uc011eac.1_Missense_Mutation_p.T727A	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	731	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGAATGACTGTAAATTGCCCA	0.398		NaN											0	0	0	0.009096	0	3	21									
FAM54A	113115	broad.mit.edu	37	6	136564027	136564027	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:136564027C>G	uc010kgp.1	-	4	643	c.253G>C	c.(253-255)GAT>CAT	p.D85H	FAM54A_uc003qgt.1_Missense_Mutation_p.D85H|FAM54A_uc003qgu.1_Missense_Mutation_p.D42H	NM_001099286	NP_001092756	Q6P444	FA54A_HUMAN	DUF729 domain containing 1	85										skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)		GCTTCTTCATCATTTGCCACA	0.358		NaN											0	0	0	0.004672	0	3	78									
STXBP5	134957	broad.mit.edu	37	6	147648324	147648324	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:147648324C>G	uc003qlz.2	+	18	2153	c.1992C>G	c.(1990-1992)CTC>CTG	p.L664L	STXBP5_uc010khz.1_Silent_p.L664L|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.L335L|STXBP5_uc003qma.2_Silent_p.L11L	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	664	WD 10.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		CAGTGCTGCTCAACCTGGGCA	0.428		NaN											0	0	0	0.021523	0	24	48									
EZR	7430	broad.mit.edu	37	6	159206483	159206483	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:159206483C>G	uc003qrt.3	-	4	540	c.325G>C	c.(325-327)GGA>CGA	p.G109R	EZR_uc011efs.1_Missense_Mutation_p.G77R|EZR_uc003qru.3_Missense_Mutation_p.G109R	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	109	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		CTAAGGATTCCTTCCTTCACT	0.532		NaN											0	0	0	0.001984	0	6	51									
PNLDC1	154197	broad.mit.edu	37	6	160237614	160237614	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:160237614T>G	uc003qsx.1	+	14	1238	c.1067T>G	c.(1066-1068)TTC>TGC	p.F356C	PNLDC1_uc003qsy.1_Missense_Mutation_p.F367C	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	356	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TATGATGCCTTCCTCTGTGGG	0.378		NaN											0	0	0	0.008361	0	25	76									
LPA	4018	broad.mit.edu	37	6	160999635	160999635	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:160999635C>T	uc003qtl.2	-	28	4511	c.4391G>A	c.(4390-4392)CGA>CAA	p.R1464Q		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3972	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CACTGGACATCGTGTCAGGTT	0.527		NaN											0	0	0	0.010504	0	21	43									
SDK1	221935	broad.mit.edu	37	7	4107520	4107520	+	Missense_Mutation	SNP	C	C	G	rs142269128		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:4107520C>G	uc003smx.2	+	20	3101	c.2962C>G	c.(2962-2964)CTC>GTC	p.L988V	SDK1_uc010kso.2_Missense_Mutation_p.L264V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	988	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGACACATCTCTCAAGGTCAG	0.423		NaN											0	0	0	0.014758	0	5	35									
CYTH3	9265	broad.mit.edu	37	7	6227347	6227347	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:6227347C>T	uc003spt.2	-	3	227	c.123G>A	c.(121-123)CTG>CTA	p.L41L		NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	41	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						TTTCATATTTCAGCCTCTGTC	0.418		NaN											0	0	0	0.012319	0	21	87									
CYTH3	9265	broad.mit.edu	37	7	6227353	6227353	+	Splice_Site	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:6227353C>T	uc003spt.2	-	3	222	c.118_splice	c.e3-1	p.R40_splice		NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						ATTTCAGCCTCTGTCAAAAAA	0.433		NaN											0	0	0	0.008871	0	20	79									
FAM126A	84668	broad.mit.edu	37	7	23030703	23030703	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:23030703C>T	uc003svm.3	-	2	283	c.28G>A	c.(28-30)GAG>AAG	p.E10K	FAM126A_uc003svn.3_Intron|FAM126A_uc011jyr.1_Missense_Mutation_p.E10K	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	10						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						AACCATTCCTCCACAACCCCT	0.303		NaN											0	0	0	0.010729	0	9	32									
CREB5	9586	broad.mit.edu	37	7	28858828	28858828	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:28858828G>T	uc003szq.2	+	11	1849	c.1459G>T	c.(1459-1461)GAG>TAG	p.E487*	CREB5_uc003szo.2_Nonsense_Mutation_p.E454*|CREB5_uc003szr.2_Nonsense_Mutation_p.E480*|CREB5_uc003szs.2_Nonsense_Mutation_p.E348*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	487					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						ATCGGTCAGCGAGGTGGTAGG	0.532		NaN											1	0	1.75199e-13	0.007291	2.39776e-13	28	107									
GLI3	2737	broad.mit.edu	37	7	42005202	42005202	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:42005202C>T	uc011kbh.1	-	15	3560	c.3469G>A	c.(3469-3471)GAC>AAC	p.D1157N	GLI3_uc011kbg.1_Missense_Mutation_p.D1098N	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1157					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATGGGCAGGTCGGTTTTGCTG	0.692		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.01441	0	55	245									
ZNF117	51351	broad.mit.edu	37	7	64439571	64439571	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:64439571T>A	uc003ttr.2	-	4	1663	c.378A>T	c.(376-378)CAA>CAT	p.Q126H		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	126	C2H2-type 1; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TTCTTTTATGTTGAGTTAGGT	0.308		NaN											0	0	0	0.001168	0	6	15									
C7orf42	55069	broad.mit.edu	37	7	66409968	66409968	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:66409968G>A	uc003tvk.2	+	3	429	c.165G>A	c.(163-165)TGG>TGA	p.W55*	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Nonsense_Mutation_p.W55*	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	55						integral to membrane				ovary(1)	1						CAAAGGATTGGAATACTTTTC	0.473		NaN											0	0	0	0.008291	0	9	71									
WBSCR17	64409	broad.mit.edu	37	7	70886021	70886021	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:70886021G>A	uc003tvy.2	+	5	892	c.892G>A	c.(892-894)GAG>AAG	p.E298K	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	298	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GTACAGCTGGGAGCTGTGGTG	0.597		NaN											0	0	0	0.01441	0	52	83									
POM121	9883	broad.mit.edu	37	7	72413873	72413873	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:72413873A>G	uc003twk.2	+	11	3341	c.3341A>G	c.(3340-3342)AAT>AGT	p.N1114S	POM121_uc003twj.2_Missense_Mutation_p.N849S|POM121_uc010lam.1_Missense_Mutation_p.N849S	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1114	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				TTTGGGATCAATGTGGCCACC	0.637		NaN											0	0	0	0.01441	0	54	17									
PHTF2	57157	broad.mit.edu	37	7	77549772	77549772	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:77549772G>C	uc003ugs.3	+	9	1079	c.953G>C	c.(952-954)GGT>GCT	p.G318A	PHTF2_uc003ugo.3_Missense_Mutation_p.G280A|PHTF2_uc003ugp.2_Missense_Mutation_p.G280A|PHTF2_uc003ugq.3_Missense_Mutation_p.G280A|PHTF2_uc010ldv.2_Missense_Mutation_p.G280A|PHTF2_uc003ugr.3_Missense_Mutation_p.G284A|PHTF2_uc003ugt.3_Missense_Mutation_p.G284A|PHTF2_uc003ugu.3_Missense_Mutation_p.G280A|PHTF2_uc003ugv.2_Missense_Mutation_p.G143A|PHTF2_uc010ldw.1_Missense_Mutation_p.G143A	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						CTGAGGAATGGTCCTAGCAAA	0.383		NaN											0	0	0	0.021022	0	35	23									
CYP51A1	1595	broad.mit.edu	37	7	91763582	91763582	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:91763582A>C	uc003ulm.3	-	1	259	c.97T>G	c.(97-99)TTG>GTG	p.L33V	CYP51A1_uc011khn.1_Intron|CYP51A1_uc003uln.3_Intron|uc003ulo.1_5'Flank	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	27	Helical; (Potential).				cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	AGCATGGACAAGAGGTTGCCG	0.687		NaN									OREG0018160	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	39									
CYP3A7	1551	broad.mit.edu	37	7	99319922	99319922	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:99319922C>T	uc003uru.2	-	3	320	c.215G>A	c.(214-216)TGG>TAG	p.W72*	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	72					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TACTCACCCCCAGACTTTTCT	0.388		NaN											0	0	0	0.001168	0	5	39									
GATS	352954	broad.mit.edu	37	7	99821277	99821277	+	Silent	SNP	T	T	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:99821277T>A	uc003uua.3	-	4	705	c.456A>T	c.(454-456)TCA>TCT	p.S152S	GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc010lgt.2_RNA|GATS_uc011kjl.1_5'Flank|GATS_uc010lgu.2_RNA	NM_178831	NP_849153	Q8NAP1	GATS_HUMAN	GATS, stromal antigen 3 opposite strand	152											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGTGAACTCTGATGACAACG	0.612		NaN											0	0	0	0.01441	0	49	217									
SRRT	51593	broad.mit.edu	37	7	100479836	100479836	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:100479836C>T	uc003uwy.2	+	6	829	c.561C>T	c.(559-561)TTC>TTT	p.F187F	SRRT_uc010lhl.1_Silent_p.F187F|SRRT_uc003uxa.2_Silent_p.F187F|SRRT_uc003uwz.2_Silent_p.F187F	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	187					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TGCAGGATTTCTTCCTGGCGC	0.587		NaN											0	0	0	0.008291	0	10	62									
MUC17	140453	broad.mit.edu	37	7	100680758	100680758	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:100680758G>A	uc003uxp.1	+	3	6114	c.6061G>A	c.(6061-6063)GAA>AAA	p.E2021K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2021	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTTCTACTGAAGGCAGTTC	0.517		NaN											0	0	0	0.01441	0	67	290									
TRIM56	81844	broad.mit.edu	37	7	100730635	100730635	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:100730635G>A	uc003uxq.2	+	3	273	c.42G>A	c.(40-42)CTG>CTA	p.L14L	TRIM56_uc003uxr.2_Silent_p.L14L	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	14					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					TGGAGGCCCTGAGCAGCGACT	0.622		NaN											0	0	0	0.008291	0	10	317									
TES	26136	broad.mit.edu	37	7	115889220	115889220	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:115889220A>G	uc003vho.2	+	3	441	c.260A>G	c.(259-261)TAT>TGT	p.Y87C	TES_uc011kmx.1_Missense_Mutation_p.Y87C|TES_uc011kmy.1_Intron|TES_uc010lka.1_Missense_Mutation_p.Y78C|TES_uc003vhp.2_Missense_Mutation_p.Y78C	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	87					negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			ATTCCCATGTATAAACGCAAT	0.403		NaN											0	0	0	0.005443	0	25	37									
PTPRZ1	5803	broad.mit.edu	37	7	121651654	121651654	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:121651654G>A	uc003vjy.2	+	12	2949	c.2554G>A	c.(2554-2556)GAT>AAT	p.D852N	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	852	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TACCGAGAGTGATAAGGTGCC	0.473		NaN											0	0	0	0.008291	0	10	81									
FAM71F1	84691	broad.mit.edu	37	7	128355536	128355536	+	Nonsense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:128355536C>G	uc003vno.1	+	1	94	c.41C>G	c.(40-42)TCA>TGA	p.S14*	FAM71F1_uc010llo.1_Intron|FAM71F1_uc011koq.1_Intron|FAM71F1_uc003vnm.1_Intron|FAM71F1_uc003vnn.1_Intron|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Nonsense_Mutation_p.S14*	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	14										skin(1)	1						TGGAGGAAATCAAAGAAGACA	0.493		NaN											0	0	0	0.01441	0	53	58									
FAM71F1	84691	broad.mit.edu	37	7	128359081	128359081	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:128359081C>G	uc003vno.1	+	3	684	c.631C>G	c.(631-633)CTT>GTT	p.L211V	FAM71F1_uc010llo.1_Missense_Mutation_p.L112V|FAM71F1_uc011koq.1_Missense_Mutation_p.L103V|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.L112V|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.L211V	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	211										skin(1)	1						CCCTAGGATTCTTGTCACGCA	0.542		NaN											0	0	0	0.01441	0	80	63									
EZH2	2146	broad.mit.edu	37	7	148526869	148526870	+	Missense_Mutation	DNP	GA	GA	AT			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:148526869_148526870GA>AT	uc003wfd.1	-	5	600_601	c.434_435TC>AT	c.(433-435)TTC>TAT	p.F145Y	EZH2_uc011kug.1_Missense_Mutation_p.F136Y|EZH2_uc003wfb.1_Missense_Mutation_p.F145Y|EZH2_uc003wfc.1_Missense_Mutation_p.F106Y|EZH2_uc011kuh.1_Missense_Mutation_p.F136Y|EZH2_uc011kui.1_Missense_Mutation_p.F145Y|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	145	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.F145C(1)		haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			GTTCTTCAATGAAAGTACCATC	0.337		NaN	Mis		DLBCL								0	0	0	0.004672	0	12	59									
ERICH1	157697	broad.mit.edu	37	8	618727	618727	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:618727C>T	uc003wph.2	-	5	1194	c.1129G>A	c.(1129-1131)GCG>ACG	p.A377T	ERICH1_uc011kwh.1_Missense_Mutation_p.A377T|ERICH1_uc003wpe.1_Missense_Mutation_p.A283T|ERICH1_uc003wpi.2_Missense_Mutation_p.A189T	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	377										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CTGTGTGACGCAAGGCGGTCC	0.517		NaN											0	0	0	0.006122	0	18	26									
SGK223	157285	broad.mit.edu	37	8	8234441	8234441	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:8234441G>C	uc003wsh.3	-	2	1478	c.1478C>G	c.(1477-1479)TCT>TGT	p.S493C		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	493							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CCCCACTGCAGAGTCAGGGCT	0.642		NaN											0	0	0	0.008291	0	9	22									
ADAM7	8756	broad.mit.edu	37	8	24324310	24324310	+	Splice_Site	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:24324310A>C	uc003xeb.2	+	6	503	c.390_splice	c.e6-2	p.R130_splice	ADAM7_uc003xea.1_Splice_Site_p.R130_splice	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAATTTCTACAGGGGATTCTT	0.383		NaN											0	0	0	0.004482	0	8	15									
PRKDC	5591	broad.mit.edu	37	8	48803019	48803019	+	Silent	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:48803019A>C	uc003xqi.2	-	33	3927	c.3870T>G	c.(3868-3870)CTT>CTG	p.L1290L	PRKDC_uc003xqj.2_Silent_p.L1290L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1290					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTGCTTTCAAAAGTGAAGACT	0.383		NaN						NHEJ					0	0	0	0.014758	0	5	11									
CHD7	55636	broad.mit.edu	37	8	61655385	61655385	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:61655385C>A	uc003xue.2	+	2	1871	c.1394C>A	c.(1393-1395)TCC>TAC	p.S465Y		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	465	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ATAGGCATGTCCTCGGCACCA	0.557		NaN											1	0	0.000274275	0.004482	0.000349923	9	39									
CHD7	55636	broad.mit.edu	37	8	61735064	61735064	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:61735064G>A	uc003xue.2	+	12	3437	c.2960G>A	c.(2959-2961)CGA>CAA	p.R987Q	CHD7_uc003xuf.2_Missense_Mutation_p.R100Q	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	987	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCCTAAAGGCGAAACTGCATT	0.343		NaN											0	0	0	0.001984	0	7	49									
CSPP1	79848	broad.mit.edu	37	8	68076741	68076741	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:68076741C>G	uc003xxi.2	+	24	2947	c.2916C>G	c.(2914-2916)ATC>ATG	p.I972M	CSPP1_uc003xxj.2_Missense_Mutation_p.I937M|CSPP1_uc003xxk.2_Missense_Mutation_p.I592M|CSPP1_uc010lyw.2_Missense_Mutation_p.I32M	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	972						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAATTCCTATCAGGCAAGTTT	0.368		NaN											0	0	0	0.013726	0	30	204									
SULF1	23213	broad.mit.edu	37	8	70536209	70536209	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:70536209A>G	uc010lza.1	+	15	2344	c.1627A>G	c.(1627-1629)ACA>GCA	p.T543A	SULF1_uc003xyd.2_Missense_Mutation_p.T543A|SULF1_uc003xye.2_Missense_Mutation_p.T543A|SULF1_uc003xyf.2_Missense_Mutation_p.T543A|SULF1_uc003xyg.2_Missense_Mutation_p.T543A|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	543					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TACTCGGCAGACACGTTCCTT	0.408		NaN											0	0	0	0.010818	0	29	138									
SLCO5A1	81796	broad.mit.edu	37	8	70585512	70585512	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:70585512G>A	uc003xyl.2	-	10	2846	c.2139C>T	c.(2137-2139)TGC>TGT	p.C713C	SLCO5A1_uc010lzb.2_Silent_p.C658C|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	713	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GCCAGAGCATGCAGGTGGTGT	0.478		NaN											0	0	0	0.00874	0	42	214									
ZFHX4	79776	broad.mit.edu	37	8	77767112	77767112	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:77767112G>T	uc003yav.2	+	10	8207	c.7820G>T	c.(7819-7821)TGG>TTG	p.W2607L	ZFHX4_uc003yau.1_Missense_Mutation_p.W2652L|ZFHX4_uc003yaw.1_Missense_Mutation_p.W2607L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2607	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTGCAAGTCTGGTTCCAGAAT	0.498		NaN								HNSCC(33;0.089)			1	0	3.83957e-06	0.016522	5.04629e-06	24	124									
DCAF4L2	138009	broad.mit.edu	37	8	88885180	88885180	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:88885180G>A	uc003ydz.2	-	1	1117	c.1020C>T	c.(1018-1020)ATC>ATT	p.I340I		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	340	WD 2.									ovary(1)	1						GGAGGCTCCAGATTCTCGTGT	0.592		NaN											0	0	0	0.00499	0	14	129									
SLC26A7	115111	broad.mit.edu	37	8	92301462	92301462	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:92301462C>A	uc003yex.2	+	4	570	c.292C>A	c.(292-294)CAT>AAT	p.H98N	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.H98N|SLC26A7_uc003yfa.2_Missense_Mutation_p.H98N	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	98	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AATGGGACATCATGTTGCCAC	0.378		NaN											1	0	0.000175454	0.010504	0.000224886	21	199									
KIAA1429	25962	broad.mit.edu	37	8	95508024	95508024	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:95508024G>A	uc003ygo.1	-	19	4492	c.4479C>T	c.(4477-4479)CTC>CTT	p.L1493L	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1493					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CCTGGTCACTGAGAGGTAAAG	0.388		NaN											0	0	0	0.016723	0	12	97									
UBR5	51366	broad.mit.edu	37	8	103354706	103354706	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:103354706C>G	uc003ykr.1	-	9	1126	c.1093G>C	c.(1093-1095)GAT>CAT	p.D365H	UBR5_uc003yks.1_Missense_Mutation_p.D365H	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	365					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AATACCTTATCAGGCCACCAC	0.408		NaN											0	0	0	0.01892	0	24	144									
PKHD1L1	93035	broad.mit.edu	37	8	110460594	110460594	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:110460594A>C	uc003yne.2	+	39	6103	c.5999A>C	c.(5998-6000)AAT>ACT	p.N2000T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2000	Extracellular (Potential).|IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TACCCGCTTAATATTCAAAAT	0.373		NaN								HNSCC(38;0.096)			0	0	0	0.014758	0	5	46									
COL14A1	7373	broad.mit.edu	37	8	121211724	121211724	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:121211724A>T	uc003yox.2	+	8	1061	c.796A>T	c.(796-798)ATC>TTC	p.I266F	COL14A1_uc003yoy.2_5'UTR|COL14A1_uc010mde.1_Intron	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	266	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGCATTTTAATCACAGATGG	0.383		NaN											0	0	0	0.00308	0	8	46									
C8orf76	84933	broad.mit.edu	37	8	124253563	124253563	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:124253563G>A	uc003yqc.1	-	1	55	c.24C>T	c.(22-24)TTC>TTT	p.F8F	C8orf76_uc003yqd.2_Intron	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	8							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ACTCGCCGCCGAACAACCAGC	0.716		NaN											0	0	0	0.010729	0	10	49									
ATAD2	29028	broad.mit.edu	37	8	124392872	124392872	+	Missense_Mutation	SNP	C	C	G	rs148295369		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:124392872C>G	uc003yqh.3	-	2	325	c.217G>C	c.(217-219)GCT>CCT	p.A73P	ATAD2_uc011lii.1_5'UTR|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.A73P	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	73					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GATCTTAAAGCACGTGTCCGG	0.358		NaN											0	0	0	0.001984	0	7	153									
KLHL38	340359	broad.mit.edu	37	8	124664510	124664510	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:124664510G>C	uc003yqs.1	-	1	681	c.657C>G	c.(655-657)TTC>TTG	p.F219L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	219	BACK.										0						TGACCTGCTTGAACAGTTCCT	0.557		NaN											0	0	0	0.012319	0	23	155									
FAM49B	51571	broad.mit.edu	37	8	130883726	130883726	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:130883726C>G	uc003yss.2	-	7	639	c.90G>C	c.(88-90)GAG>GAC	p.E30D	FAM49B_uc003yst.2_Missense_Mutation_p.E30D|FAM49B_uc003ysu.2_Missense_Mutation_p.E30D|FAM49B_uc003ysv.2_5'UTR|FAM49B_uc003ysw.2_Missense_Mutation_p.E30D|FAM49B_uc003ysx.2_Missense_Mutation_p.E30D|FAM49B_uc003ysy.1_Missense_Mutation_p.E30D	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	30											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			CCTTCTCAGACTCTGTAGGCT	0.383		NaN											0	0	0	0.008291	0	9	59									
LRRC6	23639	broad.mit.edu	37	8	133645151	133645151	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:133645151G>T	uc003ytk.2	-	5	562	c.488C>A	c.(487-489)TCA>TAA	p.S163*	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	163						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTCAATTACTGAATAGTCCTG	0.363		NaN											1	0	5.43694e-19	0.005524	7.59154e-19	39	89									
TG	7038	broad.mit.edu	37	8	134146952	134146952	+	Missense_Mutation	SNP	G	G	A	rs35054972		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:134146952G>A	uc003ytw.2	+	48	8262	c.8221G>A	c.(8221-8223)GAA>AAA	p.E2741K	TG_uc010mdw.2_Missense_Mutation_p.E1500K|TG_uc011ljb.1_Missense_Mutation_p.E1110K|TG_uc011ljc.1_Missense_Mutation_p.E874K	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2741					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCAGAGAGTGAAGAGGAGGA	0.547		NaN											0	0	0	0.005443	0	26	58									
NDRG1	10397	broad.mit.edu	37	8	134251299	134251299	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:134251299G>C	uc003yuh.2	-	16	1593	c.1007C>G	c.(1006-1008)TCT>TGT	p.S336C	NDRG1_uc003yue.1_Missense_Mutation_p.S51C|NDRG1_uc003yuf.1_Missense_Mutation_p.S147C|NDRG1_uc003yug.2_Missense_Mutation_p.S336C|NDRG1_uc010mee.2_Missense_Mutation_p.S255C|NDRG1_uc010mef.2_Missense_Mutation_p.S270C|NDRG1_uc011ljh.1_Missense_Mutation_p.S164C|NDRG1_uc011lji.1_Missense_Mutation_p.S83C|NDRG1_uc003yui.1_Intron	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	336					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GCCATCCAGAGAAGTGACGCT	0.687		NaN											0	0	0	0.014758	0	5	41									
FAM135B	51059	broad.mit.edu	37	8	139255208	139255208	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:139255208A>T	uc003yuy.2	-	7	817	c.646T>A	c.(646-648)TAC>AAC	p.Y216N	FAM135B_uc003yux.2_Missense_Mutation_p.Y117N|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	216										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCTTGCAGTACCCAGCTCCA	0.483		NaN								HNSCC(54;0.14)			0	0	0	0.013537	0	11	103									
PTK2	5747	broad.mit.edu	37	8	141712710	141712710	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:141712710G>C	uc003yvu.2	-	25	2556	c.2326C>G	c.(2326-2328)CAT>GAT	p.H776D	PTK2_uc011ljp.1_Missense_Mutation_p.H84D|PTK2_uc003yvo.2_Missense_Mutation_p.H404D|PTK2_uc011ljq.1_Missense_Mutation_p.H471D|PTK2_uc003yvp.2_Missense_Mutation_p.H444D|PTK2_uc003yvq.2_Missense_Mutation_p.H302D|PTK2_uc003yvr.2_Missense_Mutation_p.H716D|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Missense_Mutation_p.H798D|PTK2_uc003yvv.2_Missense_Mutation_p.H676D|PTK2_uc011ljr.1_Missense_Mutation_p.H776D	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	776	Interaction with TGFB1I1.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TGAGGTCTATGATTCCATGAA	0.453		NaN											0	0	0	0.012319	0	20	139									
ZNF696	79943	broad.mit.edu	37	8	144378379	144378379	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:144378379G>A	uc003yxy.3	+	3	943	c.534G>A	c.(532-534)GAG>GAA	p.E178E		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			ACAGCGGGGAGAGGCCCTACG	0.697		NaN											0	0	0	0.00308	0	7	36									
EEF1D	1936	broad.mit.edu	37	8	144662724	144662724	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:144662724C>T	uc011lki.1	-	6	833	c.564G>A	c.(562-564)AAG>AAA	p.K188K	NAPRT1_uc003yym.3_5'Flank|NAPRT1_uc003yyn.3_5'Flank|NAPRT1_uc011lkh.1_5'Flank|NAPRT1_uc003yyo.3_5'Flank|EEF1D_uc003yyp.1_Silent_p.K530K|EEF1D_uc003yyq.1_Silent_p.K604K|EEF1D_uc011lkj.1_Silent_p.K553K|EEF1D_uc003yyr.2_Silent_p.K554K|EEF1D_uc003yyt.2_Silent_p.K554K|EEF1D_uc011lkk.1_Silent_p.K188K|EEF1D_uc003yys.2_Silent_p.K188K|EEF1D_uc003yyv.2_Silent_p.K164K|EEF1D_uc003yyu.2_Silent_p.K188K|EEF1D_uc011lkl.1_Silent_p.K169K	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	188					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GTGCAGGCTTCTTGGCCTTCT	0.637		NaN											0	0	0	0.006999	0	39	241									
FRMPD1	22844	broad.mit.edu	37	9	37735728	37735728	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:37735728C>T	uc004aag.1	+	13	1442	c.1398C>T	c.(1396-1398)GTC>GTT	p.V466V	FRMPD1_uc004aah.1_Silent_p.V466V|FRMPD1_uc011lqm.1_Silent_p.V288V|FRMPD1_uc011lqn.1_Silent_p.V335V	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	466	FERM.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TTCAGGACGTCAAGGTAACAC	0.423		NaN											0	0	0	0.00874	0	42	3									
FAM75C1	441452	broad.mit.edu	37	9	90535926	90535926	+	Silent	SNP	A	A	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:90535926A>C	uc010mqi.2	+	4	1133	c.1104A>C	c.(1102-1104)CCA>CCC	p.P368P	FAM75C1_uc004apq.3_Silent_p.P351P	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CCTCTTTCCCAGTCCTATCTC	0.537		NaN											0	0	0	0.01441	0	218	409									
CTNNAL1	8727	broad.mit.edu	37	9	111745534	111745534	+	Missense_Mutation	SNP	C	C	T	rs150483984	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:111745534C>T	uc004bdo.1	-	6	833	c.791G>A	c.(790-792)CGT>CAT	p.R264H	CTNNAL1_uc010mts.1_5'UTR|CTNNAL1_uc010mtt.1_Missense_Mutation_p.R264H|CTNNAL1_uc004bdp.1_Missense_Mutation_p.R264H	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	264					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		CACTTTCATACGGTCAAATAC	0.333		NaN											0	0	0	0.016723	0	10	46									
PALM2-AKAP2	445815	broad.mit.edu	37	9	112642957	112642957	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:112642957C>A	uc004bei.2	+	3	445	c.253C>A	c.(253-255)CAG>AAG	p.Q85K	PALM2_uc004bef.2_Missense_Mutation_p.Q87K|PALM2_uc004beg.2_Missense_Mutation_p.Q87K|PALM2_uc004beh.3_Missense_Mutation_p.Q85K|PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.Q85K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.Q85K|PALM2-AKAP2_uc004bel.1_5'UTR	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGATAACATTCAGAGGTAGGT	0.527		NaN											1	0	4.72057e-08	0.021523	6.28398e-08	26	18									
ZNF483	158399	broad.mit.edu	37	9	114304279	114304279	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:114304279G>C	uc004bff.2	+	6	1288	c.1064G>C	c.(1063-1065)GGA>GCA	p.G355A	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	355					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AAAACCGCCGGAGAAAAGTCA	0.438		NaN											0	0	0	0.01441	0	105	7									
COL27A1	85301	broad.mit.edu	37	9	116930564	116930564	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:116930564G>A	uc011lxl.1	+	3	729	c.729G>A	c.(727-729)CAG>CAA	p.Q243Q	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Silent_p.Q93Q	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	243					cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ACACGTACCAGTCCCCACTGG	0.567		NaN											0	0	0	0.001984	0	7	162									
COL27A1	85301	broad.mit.edu	37	9	116931301	116931301	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:116931301C>T	uc011lxl.1	+	3	1466	c.1466C>T	c.(1465-1467)TCA>TTA	p.S489L	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.S339L	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	489	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCTTTATCCTCATCTCCTGCC	0.592		NaN											0	0	0	0.01441	0	165	254									
TNFSF8	944	broad.mit.edu	37	9	117668133	117668133	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:117668133G>C	uc004bji.1	-	3	472	c.285C>G	c.(283-285)TTC>TTG	p.F95L		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	95	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						ATGACTTCTTGAATGGAGCCC	0.413		NaN											0	0	0	0.01441	0	49	185									
TNFSF8	944	broad.mit.edu	37	9	117668170	117668170	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:117668170G>A	uc004bji.1	-	3	435	c.248C>T	c.(247-249)TCA>TTA	p.S83L		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	83	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GAGGTCTTCTGAGCAATTTCC	0.403		NaN											0	0	0	0.015359	0	31	144									
TNC	3371	broad.mit.edu	37	9	117800543	117800543	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:117800543T>C	uc004bjj.3	-	20	5871	c.5509A>G	c.(5509-5511)AAA>GAA	p.K1837E	TNC_uc010mvf.2_Missense_Mutation_p.K1564E	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1837	Fibronectin type-III 14.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						ACCTTACCTTTCTCGCCTGTG	0.517		NaN											0	0	0	0.01441	0	82	94									
GOLGA2	2801	broad.mit.edu	37	9	131020315	131020315	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:131020315C>A	uc011maw.1	-	22	2384	c.2371G>T	c.(2371-2373)GAT>TAT	p.D791Y	GOLGA2_uc010mxw.2_Missense_Mutation_p.D114Y|GOLGA2_uc004buh.2_Missense_Mutation_p.D264Y	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	791	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CACACAGAATCACCCCCGGTC	0.687		NaN											1	0	5.20837e-25	0.00874	7.32178e-25	41	63									
ZER1	10444	broad.mit.edu	37	9	131504994	131504994	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:131504994T>C	uc004bwa.1	-	9	1823	c.1390A>G	c.(1390-1392)AAC>GAC	p.N464D		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	464	ARM 1.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						ATGCTGAAGTTGCAGAGCGTC	0.617		NaN											0	0	0	0.001168	0	6	32									
USP20	10868	broad.mit.edu	37	9	132637006	132637006	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:132637006C>T	uc004bys.2	+	18	2103	c.1892C>T	c.(1891-1893)TCG>TTG	p.S631L	USP20_uc004byr.2_Missense_Mutation_p.S631L|USP20_uc004byt.1_Missense_Mutation_p.S631L	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	631					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				GACCTCCTCTCGGTCATCTGC	0.647		NaN											0	0	0	0.01441	0	49	103									
SETX	23064	broad.mit.edu	37	9	135158707	135158707	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:135158707C>G	uc004cbk.2	-	19	6673	c.6490G>C	c.(6490-6492)GAG>CAG	p.E2164Q	SETX_uc004cbj.2_Missense_Mutation_p.E1783Q|SETX_uc010mzt.2_Missense_Mutation_p.E1783Q	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2164					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AAAGCAGACTCAAGTAGTAAA	0.483		NaN											0	0	0	0.009096	0	4	116									
RXRA	6256	broad.mit.edu	37	9	137300887	137300887	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:137300887C>G	uc004cfb.2	+	4	694	c.532C>G	c.(532-534)CTG>GTG	p.L178V	RXRA_uc004cfc.1_Missense_Mutation_p.L81V	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	178	NR C4-type.|Nuclear receptor.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CAAGGACTGCCTGATTGACAA	0.627		NaN											0	0	0	0.001168	0	5	195									
SHROOM2	357	broad.mit.edu	37	X	9864156	9864156	+	Silent	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:9864156C>G	uc004csu.1	+	4	2298	c.2208C>G	c.(2206-2208)CCC>CCG	p.P736P		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	736	ASD1.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCCAGCCACCCTCATCTACAA	0.622		NaN											0	0	0	0.008291	0	9	9									
GEMIN8	54960	broad.mit.edu	37	X	14038306	14038306	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:14038306C>G	uc004cwb.2	-	4	706	c.363G>C	c.(361-363)GAG>GAC	p.E121D	GEMIN8_uc004cwc.2_Missense_Mutation_p.E121D|GEMIN8_uc004cwd.2_Missense_Mutation_p.E121D	NM_017856	NP_060326	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	121					spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0						CAGTCTCCATCTCTTCCTCTT	0.483		NaN											0	0	0	0.01441	0	115	24									
GPR64	10149	broad.mit.edu	37	X	19021018	19021018	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:19021018C>A	uc004cyx.2	-	24	2340	c.2176G>T	c.(2176-2178)GTA>TTA	p.V726L	GPR64_uc004cyy.2_Missense_Mutation_p.V723L|GPR64_uc004cyz.2_Missense_Mutation_p.V712L|GPR64_uc004czb.2_Missense_Mutation_p.V726L|GPR64_uc004czc.2_Missense_Mutation_p.V710L|GPR64_uc004czd.2_Missense_Mutation_p.V702L|GPR64_uc004cze.2_Missense_Mutation_p.V696L|GPR64_uc004czf.2_Missense_Mutation_p.V688L|GPR64_uc004cza.2_Missense_Mutation_p.V704L|GPR64_uc004cyw.2_Missense_Mutation_p.V710L|GPR64_uc010nfj.2_Missense_Mutation_p.V607L	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	726	Cytoplasmic (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					GTATTAAATACTTTGACAAGG	0.418		NaN											1	0	8.24728e-16	0.004656	1.14003e-15	25	33									
DMD	1756	broad.mit.edu	37	X	32429985	32429985	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:32429985G>T	uc004dda.1	-	30	4361	c.4117C>A	c.(4117-4119)CAG>AAG	p.Q1373K	DMD_uc004dcw.2_Missense_Mutation_p.Q29K|DMD_uc004dcx.2_Missense_Mutation_p.Q32K|DMD_uc004dcz.2_Missense_Mutation_p.Q1250K|DMD_uc004dcy.1_Missense_Mutation_p.Q1369K|DMD_uc004ddb.1_Missense_Mutation_p.Q1365K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1373					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCAGTCTCCTGGGCAGACTGG	0.418		NaN											1	0	5.18039e-06	0.00308	6.79772e-06	7	8									
EDA2R	60401	broad.mit.edu	37	X	65824270	65824270	+	Silent	SNP	C	C	T			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:65824270C>T	uc004dwq.2	-	3	356	c.345G>A	c.(343-345)GAG>GAA	p.E115E	EDA2R_uc004dwr.2_Silent_p.E115E|EDA2R_uc004dws.2_Silent_p.E115E|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Intron|EDA2R_uc010nkt.1_Silent_p.E115E|EDA2R_uc004dwt.1_Silent_p.E115E	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	115	TNFR-Cys 3.|Extracellular (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						CACATTGAACCTCAGAGGTGG	0.512		NaN											0	0	0	0.020292	0	13	28									
PGAM4	441531	broad.mit.edu	37	X	77224638	77224638	+	Silent	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:77224638G>A	uc004ecy.1	-	1	498	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	166					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CTTCATTCCAGAAGGGCAGAG	0.517		NaN											0	0	0	0.011902	0	43	53									
CENPI	2491	broad.mit.edu	37	X	100382569	100382569	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:100382569C>G	uc004egx.2	+	10	1259	c.989C>G	c.(988-990)TCT>TGT	p.S330C	CENPI_uc011mrg.1_Missense_Mutation_p.S330C|CENPI_uc004egy.2_Missense_Mutation_p.S330C	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	330					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						ATGAGTCTTTCTGATTGTCTG	0.378		NaN											0	0	0	0.014758	0	5	50									
CXorf57	55086	broad.mit.edu	37	X	105882904	105882904	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:105882904C>A	uc004emi.3	+	9	1872	c.1721C>A	c.(1720-1722)TCA>TAA	p.S574*	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	574										ovary(1)|lung(1)|breast(1)	3						GCCTCAGCATCAGAAACACTT	0.398		NaN											1	0	7.41877e-09	0.012319	9.92366e-09	21	37									
PLS3	5358	broad.mit.edu	37	X	114869355	114869355	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:114869355G>C	uc004eqd.2	+	7	1135	c.745G>C	c.(745-747)GAA>CAA	p.E249Q	PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Missense_Mutation_p.E227Q|PLS3_uc004eqe.2_Missense_Mutation_p.E249Q|PLS3_uc011mtg.1_Missense_Mutation_p.E222Q|PLS3_uc011mth.1_Missense_Mutation_p.E204Q	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	249	Actin-binding 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						AAGCAGGAATGAAGGTAATGG	0.408		NaN											0	0	0	0.007291	0	26	51									
MAGEC3	139081	broad.mit.edu	37	X	140985120	140985120	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:140985120G>A	uc011mwp.1	+	7	1576	c.1576G>A	c.(1576-1578)GAA>AAA	p.E526K	MAGEC3_uc004fbs.2_Missense_Mutation_p.E228K|MAGEC3_uc010nsj.2_Missense_Mutation_p.E228K	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	526	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTATTTCTTTGAAGACACATT	0.438		NaN											0	0	0	0.01441	0	52	99									
MTM1	4534	broad.mit.edu	37	X	149767125	149767125	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:149767125G>A	uc004fef.3	+	4	282	c.206G>A	c.(205-207)CGT>CAT	p.R69H	MTM1_uc011mxx.1_Intron|MTM1_uc011mxy.1_Missense_Mutation_p.R69H|MTM1_uc011mxz.1_Intron|MTM1_uc010nte.2_5'UTR	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	69	GRAM.		R -> P (in XCNM).|R -> C (in XCNM; mild; reduced response to PI5P and reduced binding to PI(3,5)P2).|R -> S (in XCNM; severe).		endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACAAATTATCGTCTTTATTTA	0.299		NaN											0	0	0	0.004482	0	8	13									
PGLYRP3	114771	broad.mit.edu	37	1	153270479	153270479	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:153270479delG	uc001fbn.1	-	7	1032	c.979delC	c.(979-981)CAGfs	p.Q327fs		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	327					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TACAAAGCCTGCCCAGGGGAC	0.587		NaN											NaN	NaN	NaN	NaN	NaN	98	179	---	---							
BAT2L2	23215	broad.mit.edu	37	1	171484935	171484936	+	Frame_Shift_Ins	INS	-	-	A			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:171484935_171484936insA	uc010pmg.1	+	5	723_724	c.457_458insA	c.(457-459)GAAfs	p.E153fs	BAT2L2_uc001ghq.1_Frame_Shift_Ins_p.E150fs|BAT2L2_uc001ghr.1_Frame_Shift_Ins_p.E155fs	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	153							protein C-terminus binding				0						TGGGGATCAGGAAAAAAAAGAA	0.356		NaN											NaN	NaN	NaN	NaN	NaN	7	249	---	---							
FAIM3	9214	broad.mit.edu	37	1	207087118	207087119	+	Frame_Shift_Ins	INS	-	-	G			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:207087118_207087119insG	uc001hey.2	-	2	537_538	c.358_359insC	c.(358-360)CTGfs	p.L120fs	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_Intron|FAIM3_uc010psb.1_Frame_Shift_Ins_p.L120fs	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	120	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					GTGGACATTCAGGGTGACTTTC	0.515		NaN											NaN	NaN	NaN	NaN	NaN	24	116	---	---							
MYEF2	50804	broad.mit.edu	37	15	48444460	48444460	+	Frame_Shift_Del	DEL	C	C	-			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:48444460delC	uc001zwi.3	-	11	1233	c.1109delG	c.(1108-1110)GGTfs	p.G370fs	MYEF2_uc001zwg.3_5'Flank|MYEF2_uc001zwh.3_5'Flank|MYEF2_uc001zwj.3_Frame_Shift_Del_p.G370fs	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	370	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TCCTCCAAAACCTGGACCATC	0.289		NaN											NaN	NaN	NaN	NaN	NaN	9	33	---	---							
EPX	8288	broad.mit.edu	37	17	56277646	56277650	+	Frame_Shift_Del	DEL	ATGCC	ATGCC	-			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:56277646_56277650delATGCC	uc002ivq.2	+	10	1684_1688	c.1598_1602delATGCC	c.(1597-1602)GATGCCfs	p.D533fs		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	533_534					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						AACCGTCAGGATGCCATGTTAGTGG	0.634		NaN									OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	21	221	---	---							
SRP68	6730	broad.mit.edu	37	17	74068550	74068550	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:74068550delG	uc002jqk.1	-	1	58	c.23delC	c.(22-24)CCAfs	p.P8fs	SRP68_uc010wsu.1_5'UTR|SRP68_uc002jql.1_Frame_Shift_Del_p.P8fs|GALR2_uc002jqm.1_5'Flank	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	8					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						gccgccgccTGGGACCTGCTT	0.428		NaN											NaN	NaN	NaN	NaN	NaN	25	124	---	---							
PREX2	80243	broad.mit.edu	37	8	69011949	69011949	+	Frame_Shift_Del	DEL	T	T	-			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:69011949delT	uc003xxv.1	+	23	2613	c.2586delT	c.(2584-2586)CATfs	p.H862fs	PREX2_uc003xxu.1_Frame_Shift_Del_p.H862fs|PREX2_uc011lez.1_Frame_Shift_Del_p.H797fs	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	862					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GTGATGAGCATTTTGTACAAA	0.289		NaN											NaN	NaN	NaN	NaN	NaN	13	80	---	---							
STAG2	10735	broad.mit.edu	37	X	123189994	123189994	+	Frame_Shift_Del	DEL	C	C	-			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:123189994delC	uc004etz.3	+	13	1552	c.1213delC	c.(1213-1215)CTCfs	p.L405fs	STAG2_uc004eua.2_Frame_Shift_Del_p.L405fs|STAG2_uc004eub.2_Frame_Shift_Del_p.L405fs|STAG2_uc004euc.2_Frame_Shift_Del_p.L405fs|STAG2_uc004eud.2_Frame_Shift_Del_p.L405fs|STAG2_uc004eue.2_Frame_Shift_Del_p.L405fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	405					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGAAGAAGTTCTCACTGCAGA	0.363		NaN											NaN	NaN	NaN	NaN	NaN	57	21	---	---