Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PLCH2	9651	broad.mit.edu	37	1	2409941	2409941	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:2409941G>A	uc001aji.1	+	2	425	c.151G>A	c.(151-153)GAG>AAG	p.E51K	PLCH2_uc010nyz.1_5'Flank|PLCH2_uc009vle.1_5'Flank|PLCH2_uc001ajj.1_5'Flank|PLCH2_uc001ajk.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	51	PH.|Necessary for plasma membrane localization (By similarity).				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TGCCATGCAAGAGGGGATGCA	0.662		NaN											0	0	0	0.000308642	0	14	46									
CNR2	1269	broad.mit.edu	37	1	24201432	24201432	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:24201432G>A	uc001bif.2	-	2	803	c.676C>T	c.(676-678)CAC>TAC	p.H226Y		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	226	Cytoplasmic (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	CTGTCCTGGTGGCCAGACAAG	0.567		NaN											0	0	0	0.000422831	0	15	31									
MAP7D1	55700	broad.mit.edu	37	1	36636771	36636771	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:36636771G>A	uc001bzz.2	+	2	462	c.246G>A	c.(244-246)CCG>CCA	p.P82P	MAP7D1_uc001caa.2_Silent_p.P82P|MAP7D1_uc001cab.2_Silent_p.P82P|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	82	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CAGCCCCCCCGCAGGAAGAGT	0.647		NaN											0	0	0	0.000339439	0	33	55									
HFM1	164045	broad.mit.edu	37	1	91778984	91778984	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:91778984T>C	uc001doa.3	-	30	3413	c.3313A>G	c.(3313-3315)ACT>GCT	p.T1105A	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.T784A|HFM1_uc001dob.3_Missense_Mutation_p.T293A|HFM1_uc010osv.1_Missense_Mutation_p.T789A	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1105							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CTTTGCATAGTGATTTGATTT	0.323		NaN											0	0	0	0.00111076	0	37	51									
LCE1E	353135	broad.mit.edu	37	1	152760035	152760035	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:152760035G>A	uc001fan.2	+	2	313	c.260G>A	c.(259-261)CGT>CAT	p.R87H		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	87	Cys-rich.				keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGTCCCACCGTCACAGACCC	0.687		NaN											0	0	0	0.000442599	0	7	112									
FCER1A	2205	broad.mit.edu	37	1	159275915	159275915	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:159275915G>A	uc001ftq.2	+	5	568	c.469G>A	c.(469-471)GAG>AAG	p.E157K		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	157	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GTACTGGTATGAGAACCACAA	0.502		NaN											0	0	0	0.000274275	0	8	39									
RC3H1	149041	broad.mit.edu	37	1	173907942	173907942	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:173907942G>C	uc001gju.3	-	19	3406	c.3319C>G	c.(3319-3321)CTG>GTG	p.L1107V	RC3H1_uc010pms.1_Missense_Mutation_p.L1098V|RC3H1_uc001gjv.2_Missense_Mutation_p.L1099V|RC3H1_uc010pmt.1_Missense_Mutation_p.L1108V	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	1107					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GACAGGTTCAGAGAGCTGGTC	0.443		NaN											0	0	0	0.000279167	0	31	65									
NUAK2	81788	broad.mit.edu	37	1	205273537	205273537	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:205273537G>A	uc001hce.2	-	7	1055	c.928C>T	c.(928-930)CGA>TGA	p.R310*		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	310					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TCTCCCACTCGGGTGGCGTAG	0.692		NaN											0	0	0	0.000602214	0	5	18									
CABC1	56997	broad.mit.edu	37	1	227153387	227153388	+	Missense_Mutation	DNP	CG	CG	AT	rs145350362		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:227153387_227153388CG>AT	uc001hqm.1	+	9	4023_4024	c.604_605CG>AT	c.(604-606)CGG>ATG	p.R202M	CABC1_uc001hqn.1_Missense_Mutation_p.R202M|CABC1_uc009xeq.1_Missense_Mutation_p.R150M|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_Translation_Start_Site	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	202					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CGAGCATGCCCGGGAGCGGAAG	0.639		NaN											0	0	0	6.4e-05	0	6	65									
OBSCN	84033	broad.mit.edu	37	1	228433250	228433250	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:228433250G>A	uc009xez.1	+	12	3662	c.3618G>A	c.(3616-3618)CTG>CTA	p.L1206L	OBSCN_uc001hsn.2_Silent_p.L1206L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1206	Ig-like 12.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAAGAAGCTGAGCTCCAGCT	0.602		NaN											0	0	0	0.000953801	0	36	77									
PGBD5	79605	broad.mit.edu	37	1	230492669	230492669	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:230492669C>T	uc010pwb.1	-	2	523	c.523G>A	c.(523-525)GAC>AAC	p.D175N	PGBD5_uc001htv.2_Missense_Mutation_p.D274N	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	175						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		AAGGCAGAGTCGAAGCTGTTC	0.612		NaN											0	0	0	0.000157383	0	6	102									
KIAA1217	56243	broad.mit.edu	37	10	24762637	24762637	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:24762637G>A	uc001iru.3	+	6	1730	c.1327G>A	c.(1327-1329)GAA>AAA	p.E443K	KIAA1217_uc001irs.2_Missense_Mutation_p.E363K|KIAA1217_uc001irt.3_Missense_Mutation_p.E443K|KIAA1217_uc010qcy.1_Missense_Mutation_p.E443K|KIAA1217_uc010qcz.1_Missense_Mutation_p.E443K|KIAA1217_uc001irv.1_Missense_Mutation_p.E293K|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.E161K|KIAA1217_uc001irz.2_Missense_Mutation_p.E161K|KIAA1217_uc001irx.2_Missense_Mutation_p.E161K|KIAA1217_uc001iry.2_Missense_Mutation_p.E161K	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	443					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AATGCAAGCGGAAATGCATAT	0.517		NaN											0	0	0	0.00106085	0	28	40									
PARD3	56288	broad.mit.edu	37	10	34648183	34648183	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:34648183C>G	uc010qej.1	-	14	1959	c.1959G>C	c.(1957-1959)AAG>AAC	p.K653N	PARD3_uc010qek.1_Missense_Mutation_p.K653N|PARD3_uc010qel.1_Missense_Mutation_p.K653N|PARD3_uc010qem.1_Missense_Mutation_p.K640N|PARD3_uc010qen.1_Missense_Mutation_p.K640N|PARD3_uc010qeo.1_Missense_Mutation_p.K640N|PARD3_uc010qep.1_Missense_Mutation_p.K596N|PARD3_uc010qeq.1_Missense_Mutation_p.K596N|PARD3_uc001ixo.1_Missense_Mutation_p.K370N|PARD3_uc001ixp.1_Missense_Mutation_p.K518N|PARD3_uc001ixq.1_Missense_Mutation_p.K640N|PARD3_uc001ixr.1_Missense_Mutation_p.K653N|PARD3_uc001ixt.1_Missense_Mutation_p.K474N|PARD3_uc001ixu.1_Missense_Mutation_p.K596N|PARD3_uc001ixs.1_Missense_Mutation_p.K306N	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	653	PDZ 3.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTTGGTTTGTCTTGCCCAACA	0.413		NaN											0	0	0	0.000781405	0	43	85									
HIF1AN	55662	broad.mit.edu	37	10	102296389	102296389	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:102296389G>A	uc001krj.3	+	2	474	c.399G>A	c.(397-399)CAG>CAA	p.Q133Q		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	133	Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		AGAAACTGCAGGATATACAGC	0.398		NaN											0	0	0	0.000374591	0	39	119									
PSTK	118672	broad.mit.edu	37	10	124740004	124740004	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:124740004C>T	uc001lgy.1	+	1	449	c.9C>T	c.(7-9)ACC>ACT	p.T3T		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	3							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GCATGAAGACCGCCGAGAACA	0.701		NaN									OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978159	0	10	13									
FAM175B	23172	broad.mit.edu	37	10	126523363	126523363	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:126523363C>T	uc001lib.3	+	9	1116	c.1071C>T	c.(1069-1071)GAC>GAT	p.D357D		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	357						BRISC complex	polyubiquitin binding				0						GTGGGGCTGACCTTCCTCCTC	0.493		NaN											0	0	0	0.000157383	0	8	23									
FJX1	24147	broad.mit.edu	37	11	35640997	35640997	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:35640997C>T	uc001mwh.2	+	1	1263	c.813C>T	c.(811-813)GCC>GCT	p.A271A		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	271						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				TCCGGGATGCCGGGGGTGAGC	0.677		NaN											0	0	0	0.00024832	0	4	33									
OR5R1	219479	broad.mit.edu	37	11	56185064	56185064	+	Silent	SNP	G	G	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:56185064G>T	uc010rji.1	-	1	645	c.645C>A	c.(643-645)CTC>CTA	p.L215L		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGTAGGAGGTGAGGACAATGG	0.468		NaN											1	0	2.70639e-06	0.000295444	2.5161e-05	22	40									
TNKS1BP1	85456	broad.mit.edu	37	11	57077076	57077076	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:57077076C>G	uc001njr.2	-	5	3421	c.3109G>C	c.(3109-3111)GAT>CAT	p.D1037H	TNKS1BP1_uc001njs.2_Missense_Mutation_p.D1037H|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.D488H	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1037	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				AGTGCCCCATCCGGCACGTGG	0.637		NaN											0	0	0	0.000781405	0	45	106									
SPTBN2	6712	broad.mit.edu	37	11	66468734	66468734	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:66468734G>T	uc001ojd.2	-	16	2908	c.2836C>A	c.(2836-2838)CTG>ATG	p.L946M		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	946	Spectrin 6.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCGTCTGCCAGACGCCGAAAC	0.582		NaN											1	0	5.35267e-07	0.000958276	5.09574e-06	19	43									
MOGAT2	80168	broad.mit.edu	37	11	75438555	75438555	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:75438555G>A	uc010rru.1	+	3	346	c.346G>A	c.(346-348)GGA>AGA	p.G116R	MOGAT2_uc001oww.1_Missense_Mutation_p.G116R|MOGAT2_uc010rrv.1_Missense_Mutation_p.G34R	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	116	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					CCTGGCAGTCGGAGCCTTTGC	0.602		NaN											0	0	0	0.000566183	0	16	176									
INTS4	92105	broad.mit.edu	37	11	77605369	77605369	+	Missense_Mutation	SNP	T	T	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:77605369T>G	uc001oys.2	-	19	2283	c.2255A>C	c.(2254-2256)GAA>GCA	p.E752A	C11orf67_uc001oyp.2_Intron|C11orf67_uc001oyr.1_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	752					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TAAAAATTTTTCACACATCCC	0.353		NaN											0	0	0	0.000958276	0	19	25									
C11orf53	341032	broad.mit.edu	37	11	111156561	111156561	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:111156561C>T	uc001plc.2	+	4	640	c.493C>T	c.(493-495)CAT>TAT	p.H165Y		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	165											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		ATACTCGCTGCATGCTCTGGA	0.617		NaN											0	0	0	0.000409698	0	33	66									
GYS2	2998	broad.mit.edu	37	12	21757466	21757466	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:21757466C>G	uc001rfb.2	-	1	316	c.61G>C	c.(61-63)GAA>CAA	p.E21Q		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	21					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						GGAAGTTCTTCGACTTCCCAC	0.493		NaN											0	0	0	0.000184323	0	29	54									
ADAMTS20	80070	broad.mit.edu	37	12	43771260	43771260	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:43771260G>C	uc010skx.1	-	32	4903	c.4903C>G	c.(4903-4905)CAA>GAA	p.Q1635E		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1635	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGGCATTCTTGATAAACTATA	0.428		NaN											0	0	0	0.000978159	0	12	23									
ADAMTS20	80070	broad.mit.edu	37	12	43886428	43886428	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:43886428C>A	uc010skx.1	-	6	956	c.956G>T	c.(955-957)GGA>GTA	p.G319V		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	319	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AATGACTGGTCCTTCCTATGC	0.363		NaN											1	0	4.68919e-08	0.000673444	4.50011e-07	9	42									
PPFIA2	8499	broad.mit.edu	37	12	81688723	81688723	+	Missense_Mutation	SNP	A	A	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:81688723A>G	uc001szo.1	-	24	2977	c.2816T>C	c.(2815-2817)ATC>ACC	p.I939T	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	865										ovary(3)|lung(2)|pancreas(1)	6						TTCTCTCTGGATCTCAGTGTC	0.488		NaN											0	0	0	0.00024832	0	4	22									
PLEKHG7	440107	broad.mit.edu	37	12	93149620	93149620	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:93149620G>A	uc001tcj.2	+	7	740	c.510G>A	c.(508-510)GTG>GTA	p.V170V		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	170	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						AAGGAAAAGTGAAGTGGCTGG	0.383		NaN											0	0	0	0.00106085	0	27	65									
CCDC63	160762	broad.mit.edu	37	12	111319049	111319049	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:111319049G>A	uc001trv.1	+	7	997	c.802G>A	c.(802-804)GTC>ATC	p.V268I	CCDC63_uc009zvt.1_3'UTR|CCDC63_uc010sye.1_Missense_Mutation_p.V228I|CCDC63_uc001trw.1_Missense_Mutation_p.V183I	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	268	Potential.									skin(6)|ovary(1)|pancreas(1)	8						CTTCCTGCTCGTCAAGCTGAA	0.498		NaN											0	0	0	0.000978159	0	12	28									
SNX6	58533	broad.mit.edu	37	14	35036931	35036931	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr14:35036931A>T	uc001wsf.1	-	13	1172	c.1164T>A	c.(1162-1164)AAT>AAA	p.N388K	SNX6_uc001wse.1_Missense_Mutation_p.N260K|SNX6_uc010tpm.1_Missense_Mutation_p.N264K	NM_152233	NP_689419	Q9UNH7	SNX6_HUMAN	sorting nexin 6 isoform b	376					cell communication|intracellular protein transport|negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|retrograde transport, endosome to Golgi	cytoplasmic vesicle membrane|early endosome membrane|nucleus	phosphatidylinositol binding|protein homodimerization activity				0	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00199)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.0245)		GTTCCACTAAATTTTTTCTGA	0.269		NaN											0	0	0	0.000295444	0	21	46									
MTHFD1	4522	broad.mit.edu	37	14	64921557	64921557	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr14:64921557C>T	uc001xhb.2	+	26	3069	c.2682C>T	c.(2680-2682)AGC>AGT	p.S894S	MTHFD1_uc010aqf.2_Silent_p.S950S|ZBTB25_uc001xhc.2_Intron	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	894	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCCGCGCCAGCGTTGGGGCTG	0.532		NaN											0	0	0	0.000319135	0	37	93									
KIF26A	26153	broad.mit.edu	37	14	104641739	104641739	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr14:104641739G>A	uc001yos.3	+	12	2614	c.2614G>A	c.(2614-2616)GCC>ACC	p.A872T		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	872					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGCCAGCCCCGCCCGAGGGGG	0.711		NaN											0	0	0	0.000978159	0	10	16									
LRRC49	54839	broad.mit.edu	37	15	71302329	71302329	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr15:71302329G>C	uc002asw.2	+	13	1838	c.1591G>C	c.(1591-1593)GAG>CAG	p.E531Q	LRRC49_uc002asu.2_Missense_Mutation_p.E521Q|LRRC49_uc002asx.2_Missense_Mutation_p.E487Q|LRRC49_uc010ukf.1_Missense_Mutation_p.E536Q|LRRC49_uc002asy.2_Missense_Mutation_p.E237Q|LRRC49_uc002asz.2_Missense_Mutation_p.E503Q	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	531						cytoplasm|microtubule				ovary(1)	1						AAATGGAACAGAGGTAAGCTA	0.299		NaN											0	0	0	0.000132079	0	19	39									
MAN2C1	4123	broad.mit.edu	37	15	75651976	75651976	+	Missense_Mutation	SNP	C	C	A	rs147452674		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr15:75651976C>A	uc002baf.2	-	16	1950	c.1933G>T	c.(1933-1935)GGG>TGG	p.G645W	MAN2C1_uc002bag.2_Missense_Mutation_p.G645W|MAN2C1_uc002bah.2_Missense_Mutation_p.G645W|MAN2C1_uc010bkk.2_Missense_Mutation_p.G546W|MAN2C1_uc010umi.1_Missense_Mutation_p.G427W	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	645					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CTGTGGGCCCCGCCCGGTTTG	0.647		NaN											1	0	2.94398e-08	0.000958276	2.84824e-07	16	36									
MYLK3	91807	broad.mit.edu	37	16	46766260	46766260	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:46766260C>A	uc002eei.3	-	4	1438	c.1322G>T	c.(1321-1323)GGG>GTG	p.G441V	MYLK3_uc010vge.1_Missense_Mutation_p.G100V|MYLK3_uc002eej.1_Missense_Mutation_p.G100V	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	441					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GCCCAGGGCCCCAACCTCGTG	0.662		NaN											1	0	1.67305e-13	0.000228196	1.68723e-12	38	102									
BANP	54971	broad.mit.edu	37	16	88098939	88098939	+	Splice_Site	SNP	G	G	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:88098939G>T	uc002fkr.2	+	12	1565	c.1341_splice	c.e12+1	p.Q447_splice	BANP_uc002fkp.2_Splice_Site_p.Q420_splice|BANP_uc002fkq.2_Intron|BANP_uc010vow.1_Intron|BANP_uc002fks.3_Intron	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b						cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		cagtggccaggtgagtccttt	0		NaN											1	0	2.23348e-06	0.000422831	2.09279e-05	15	35									
SNAI3	333929	broad.mit.edu	37	16	88745035	88745035	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:88745035C>T	uc002flj.2	-	3	768	c.700G>A	c.(700-702)GAG>AAG	p.E234K	MGC23284_uc002fli.3_Intron	NM_178310	NP_840101	Q3KNW1	SNAI3_HUMAN	snail homolog 3	234					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)		TAGGGCTTCTCCCCTGTGGGA	0.612		NaN											0	0	0	0.000219431	0	15	23									
GALNS	2588	broad.mit.edu	37	16	88893122	88893122	+	Missense_Mutation	SNP	C	C	T	rs150734270	byFrequency	TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:88893122C>T	uc002fly.3	-	10	1216	c.1127G>A	c.(1126-1128)CGG>CAG	p.R376Q	GALNS_uc010cid.2_Missense_Mutation_p.R382Q|GALNS_uc002flz.3_Missense_Mutation_p.R59Q	NM_000512	NP_000503	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	376			R -> Q (in MPS4A; severe form).			lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GTCCATCAGCCGGCCCTGCAG	0.662		NaN											0	0	0	0.000586117	0	21	20									
MYBBP1A	10514	broad.mit.edu	37	17	4445105	4445105	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:4445105C>A	uc002fyb.3	-	23	3231	c.3169G>T	c.(3169-3171)GGC>TGC	p.G1057C	MYBBP1A_uc002fxz.3_Missense_Mutation_p.G1057C|MYBBP1A_uc002fya.3_Missense_Mutation_p.G2C|MYBBP1A_uc010vsa.1_Missense_Mutation_p.G99C	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	1057					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						AGGACCTGGCCCATCAGCTGC	0.627		NaN											1	0	1.99505e-19	0.000409698	2.02916e-18	30	96									
NCOR1	9611	broad.mit.edu	37	17	16029478	16029478	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:16029478C>A	uc002gpo.2	-	15	1792	c.1552G>T	c.(1552-1554)GAA>TAA	p.E518*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.E518*|NCOR1_uc002gpp.1_Nonsense_Mutation_p.E409*|NCOR1_uc002gpr.2_Nonsense_Mutation_p.E409*|NCOR1_uc002gps.1_Nonsense_Mutation_p.E527*|NCOR1_uc010coz.1_Nonsense_Mutation_p.E334*|NCOR1_uc010cpb.1_Nonsense_Mutation_p.E528*|NCOR1_uc010cpa.1_Nonsense_Mutation_p.E519*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	518	Potential.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ttatcctcttctttttcttct	0.179		NaN											1	0	6.49762e-13	0.00074312	6.49762e-12	19	28									
SLC13A2	9058	broad.mit.edu	37	17	26821083	26821083	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:26821083C>T	uc002hbh.2	+	8	1213	c.1146C>T	c.(1144-1146)TTC>TTT	p.F382F	SLC13A2_uc010wal.1_3'UTR|SLC13A2_uc010wam.1_Silent_p.F338F|SLC13A2_uc010wan.1_Silent_p.F431F|SLC13A2_uc010wao.1_Silent_p.F339F|SLC13A2_uc002hbi.2_Silent_p.F311F	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	382	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	TAATTATGTTCATCATACCCT	0.607		NaN											0	0	0	0.000175454	0	17	91									
SRCIN1	80725	broad.mit.edu	37	17	36705305	36705305	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:36705305G>A	uc002hqd.2	-	16	3329	c.3104C>T	c.(3103-3105)TCG>TTG	p.S1035L	SRCIN1_uc002hqf.1_Missense_Mutation_p.S907L|SRCIN1_uc002hqe.2_Missense_Mutation_p.S889L	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	907					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						GATGAAGGCCGAGTCCTTCTT	0.632		NaN											0	0	0	0.000319135	0	35	62									
C17orf57	124989	broad.mit.edu	37	17	45447812	45447812	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:45447812T>C	uc002iln.2	+	11	1226	c.815T>C	c.(814-816)ATG>ACG	p.M272T	C17orf57_uc002ilm.2_Missense_Mutation_p.M176T|C17orf57_uc002ill.1_Missense_Mutation_p.M28T|C17orf57_uc010daz.1_Missense_Mutation_p.M224T	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	272							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GGTAACCACATGGTGGATATT	0.318		NaN											0	0	0	0.000375601	0	23	54									
ANKRD30B	374860	broad.mit.edu	37	18	14779986	14779986	+	Missense_Mutation	SNP	G	G	A	rs76927023	byFrequency	TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr18:14779986G>A	uc010dlo.2	+	11	1628	c.1448G>A	c.(1447-1449)CGA>CAA	p.R483Q	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	483										ovary(1)|skin(1)	2						GAATCCAAACGAGAGGAAGAT	0.284		NaN											0	0	0	0.000673444	0	7	29									
CCDC102B	79839	broad.mit.edu	37	18	66678339	66678339	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr18:66678339G>A	uc002lkk.2	+	9	1655	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K	CCDC102B_uc002lki.2_Missense_Mutation_p.E478K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	478	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AAAAGAAGATGAGGTACTACT	0.368		NaN											0	0	0	3.59834e-05	0	6	33									
MUC16	94025	broad.mit.edu	37	19	9014673	9014673	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:9014673C>G	uc002mkp.2	-	31	38506	c.38302G>C	c.(38302-38304)GAT>CAT	p.D12768H	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12770	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGATGGCATCCACTCCAGTG	0.547		NaN											0	0	0	0.000227799	0	20	28									
MUC16	94025	broad.mit.edu	37	19	9017487	9017487	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:9017487C>G	uc002mkp.2	-	26	38041	c.37837G>C	c.(37837-37839)GAT>CAT	p.D12613H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12615	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGATGGCATCCACTCCAGTG	0.547		NaN											0	0	0	0.00010058	0	8	75									
COL5A3	50509	broad.mit.edu	37	19	10116237	10116237	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:10116237G>A	uc002mmq.1	-	4	677	c.591C>T	c.(589-591)TTC>TTT	p.F197F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	197	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTCCTACCTCGAAAGTCTTTT	0.532		NaN											0	0	0	0.000151284	0	11	96									
ICAM3	3385	broad.mit.edu	37	19	10445810	10445811	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:10445810_10445811CG>AT	uc002mob.2	-	4	923_924	c.868_869CG>AT	c.(868-870)CGG>ATG	p.R290M	RAVER1_uc002moa.2_5'Flank|ICAM3_uc010dxd.1_Missense_Mutation_p.R213M|ICAM3_uc010xlf.1_3'UTR	NM_002162	NP_002153	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3 precursor	290	Extracellular (Potential).|Ig-like C2-type 3.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			GACGATCTCCCGGGCACCCTCC	0.668		NaN											0	0	0	6.4e-05	0	13	274									
CYP4F12	66002	broad.mit.edu	37	19	15791063	15791063	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:15791063C>T	uc002nbl.2	+	4	414	c.353C>T	c.(352-354)GCA>GTA	p.A118V	CYP4F12_uc010xoo.1_Missense_Mutation_p.A118V|CYP4F12_uc010xop.1_Missense_Mutation_p.A118V	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GCTGCCATTGCACCCAAGGAT	0.567		NaN											0	0	0	0.000781405	0	67	174									
MAST3	23031	broad.mit.edu	37	19	18245741	18245741	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:18245741G>A	uc002nhz.3	+	16	1732	c.1732G>A	c.(1732-1734)GTG>ATG	p.V578M		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	578	Protein kinase.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GGTGGGCTGCGTGCCTTTCTT	0.617		NaN											0	0	0	0.000781405	0	45	91									
ZNF569	148266	broad.mit.edu	37	19	37903795	37903795	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:37903795G>A	uc002ogi.2	-	6	2323	c.1765C>T	c.(1765-1767)CAA>TAA	p.Q589*	ZNF569_uc002ogh.2_Nonsense_Mutation_p.Q430*|ZNF569_uc002ogj.2_Nonsense_Mutation_p.Q613*	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	589	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGTTCTTTGAGAGAAGGCT	0.418		NaN											0	0	0	0.000339439	0	32	72									
SIPA1L3	23094	broad.mit.edu	37	19	38682830	38682830	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:38682830G>A	uc002ohk.2	+	17	4985	c.4476G>A	c.(4474-4476)TTG>TTA	p.L1492L		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1492					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AACCGAGGTTGAGGGCATCCC	0.552		NaN											0	0	0	0.000295444	0	21	44									
NUMBL	9253	broad.mit.edu	37	19	41188699	41188699	+	Silent	SNP	T	T	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:41188699T>C	uc002oon.2	-	5	501	c.333A>G	c.(331-333)CGA>CGG	p.R111R	NUMBL_uc010xvq.1_Silent_p.R70R|NUMBL_uc002ooo.2_Silent_p.R111R|NUMBL_uc010xvr.1_Silent_p.R70R	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	111	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			TCACGGACTTTCGGCCCATCT	0.657		NaN											0	0	0	0.000308642	0	15	55									
ERCC2	2068	broad.mit.edu	37	19	45867337	45867337	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:45867337G>A	uc002pbj.2	-	10	903	c.856C>T	c.(856-858)CGG>TGG	p.R286W	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.R208W|ERCC2_uc002pbk.2_Missense_Mutation_p.R262W|ERCC2_uc002pbl.3_Missense_Mutation_p.R262W|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	286					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		ACCAGACGCCGGTACTCGTCC	0.701		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.000274275	0	9	16									
PLA2G4C	8605	broad.mit.edu	37	19	48609779	48609779	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:48609779C>T	uc002phx.2	-	2	406	c.8G>A	c.(7-9)AGC>AAC	p.S3N	PLA2G4C_uc002phw.2_5'Flank|PLA2G4C_uc010elr.2_Missense_Mutation_p.S3N|PLA2G4C_uc010xzd.1_Silent_p.K23K|PLA2G4C_uc002phy.3_Missense_Mutation_p.S3N	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	3	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		GAGGACTTACCTTCCCATGGT	0.502		NaN											0	0	0	0.000319135	0	38	82									
NBAS	51594	broad.mit.edu	37	2	15676631	15676631	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:15676631C>G	uc002rcc.1	-	8	584	c.558G>C	c.(556-558)TTG>TTC	p.L186F	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	186										ovary(2)|liver(1)|skin(1)	4						CTAAAAATATCAACCCAGCAA	0.348		NaN											0	0	0	0.000781405	0	64	179									
MATN3	4148	broad.mit.edu	37	2	20202935	20202935	+	Silent	SNP	C	C	T	rs139419822	by1000genomes	TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:20202935C>T	uc002rdl.2	-	3	966	c.903G>A	c.(901-903)AAG>AAA	p.K301K	MATN3_uc010exu.1_Intron	NM_002381	NP_002372	O15232	MATN3_HUMAN	matrilin 3 precursor	301	EGF-like 1.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACACGTTTTCTTGTCGGCAT	0.527		NaN											0	0	0	0.000295444	0	20	45									
TMEM214	54867	broad.mit.edu	37	2	27259978	27259978	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:27259978G>T	uc002ria.3	+	8	1052	c.942G>T	c.(940-942)ATG>ATT	p.M314I	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.M269I	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	314						integral to membrane	protein binding				0						GCTTCGGCATGATTGGCCCCA	0.567		NaN											1	0	3.8128e-34	0.000781405	3.91141e-33	65	163									
C2orf53	339779	broad.mit.edu	37	2	27361074	27361074	+	Nonsense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:27361074G>A	uc002rjb.2	-	3	704	c.124C>T	c.(124-126)CAG>TAG	p.Q42*		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	42	Pro-rich.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGGCCCTGATGGGGAGAG	0.627		NaN											0	0	0	0.00074312	0	19	30									
ACYP2	98	broad.mit.edu	37	2	54531938	54531938	+	Silent	SNP	A	A	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:54531938A>G	uc002rxq.3	+	4	725	c.299A>G	c.(298-300)TAA>TGA	p.*100*		NM_138448	NP_612457	P14621	ACYP2_HUMAN	acylphosphatase 2	100					phosphate metabolic process		acylphosphatase activity				0						ATTAGATACTAATAGAAGAGA	0.333		NaN											0	0	0	0.000151284	0	14	16									
PAPOLG	64895	broad.mit.edu	37	2	60996024	60996024	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:60996024G>A	uc002sai.2	+	5	668	c.437G>A	c.(436-438)AGA>AAA	p.R146K	PAPOLG_uc002saj.2_5'UTR|PAPOLG_uc002sak.2_5'UTR	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	146					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			AGAAACTTAAGAGTAAGTATC	0.284		NaN											0	0	0	0.00010058	0	12	15									
EIF2AK3	9451	broad.mit.edu	37	2	88894996	88894996	+	Silent	SNP	A	A	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:88894996A>G	uc002stc.3	-	3	826	c.624T>C	c.(622-624)TAT>TAC	p.Y208Y		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	208	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						CCTTTCCACTATATGCACTGA	0.318		NaN											0	0	0	0.000566183	0	16	37									
BOLL	66037	broad.mit.edu	37	2	198621229	198621229	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:198621229A>T	uc002uus.2	-	9	962	c.652T>A	c.(652-654)TAT>AAT	p.Y218N	uc002uup.2_Intron|BOLL_uc002uur.2_Missense_Mutation_p.Y224N|BOLL_uc002uut.2_Missense_Mutation_p.Y230N|BOLL_uc010zha.1_Missense_Mutation_p.Y109N|BOLL_uc002uuu.1_Missense_Mutation_p.Y246N	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2	218					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						ACTGGTTGATAAATAACCTCA	0.373		NaN											0	0	0	0.000274275	0	8	28									
PIKFYVE	200576	broad.mit.edu	37	2	209189658	209189658	+	Silent	SNP	A	A	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:209189658A>T	uc002vcz.2	+	19	2513	c.2355A>T	c.(2353-2355)CGA>CGT	p.R785R	PIKFYVE_uc010fun.1_Silent_p.R466R|PIKFYVE_uc002vcy.1_Silent_p.R729R	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	785					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GAATCAGTCGAATGACCCAAG	0.343		NaN											0	0	0	0.00106085	0	25	58									
CXCR2	3579	broad.mit.edu	37	2	219000386	219000386	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:219000386C>T	uc002vgz.1	+	4	1087	c.862C>T	c.(862-864)CGC>TGC	p.R288C	CXCR2_uc002vha.1_Missense_Mutation_p.R288C|CXCR2_uc002vhb.1_Missense_Mutation_p.R288C	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	288	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						GACCTGTGAGCGCCGCAATCA	0.592		NaN											0	0	0	8.12818e-05	0	7	95									
FAM134A	79137	broad.mit.edu	37	2	220047272	220047272	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:220047272C>T	uc002vjw.3	+	9	1689	c.1553C>T	c.(1552-1554)CCT>CTT	p.P518L	FAM134A_uc010fwc.2_Missense_Mutation_p.P311L|FAM134A_uc002vjx.2_Missense_Mutation_p.P276L	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	518						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAAAACCCCCTGATGCTCCA	0.607		NaN											0	0	0	0.000720815	0	27	66									
TMEM198	130612	broad.mit.edu	37	2	220412380	220412380	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:220412380G>A	uc002vme.2	+	4	904	c.319G>A	c.(319-321)GGG>AGG	p.G107R	TMEM198_uc002vmf.2_Missense_Mutation_p.G107R	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	107	Helical; (Potential).|Leu-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCTGCTCTGCGGGCTGGTGGC	0.687		NaN											0	0	0	0.000151284	0	14	125									
MTERFD2	130916	broad.mit.edu	37	2	242039054	242039054	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:242039054C>G	uc002wan.1	-	1	857	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	MTERFD2_uc010zoj.1_Intron|MTERFD2_uc010zok.1_Missense_Mutation_p.E93Q	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	93										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		ATGACCCTCTCTAGCTCCAAG	0.507		NaN											0	0	0	0.000781405	0	44	82									
ZNF343	79175	broad.mit.edu	37	20	2464291	2464291	+	Missense_Mutation	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:2464291C>A	uc002wge.1	-	6	1804	c.1316G>T	c.(1315-1317)TGC>TTC	p.C439F	ZNF343_uc010gao.1_Missense_Mutation_p.C439F|ZNF343_uc002wgd.1_Missense_Mutation_p.C349F	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	439	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACACTCCCTGCAAACATAAGG	0.522		NaN											1	0	6.72482e-11	0.000308642	6.61367e-10	16	41									
DLGAP4	22839	broad.mit.edu	37	20	35064675	35064675	+	Nonsense_Mutation	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:35064675C>A	uc002xff.2	+	4	1598	c.1163C>A	c.(1162-1164)TCA>TAA	p.S388*	DLGAP4_uc010zvp.1_Nonsense_Mutation_p.S388*	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	388					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCAAGCCCTCACCCAAGACC	0.711		NaN											1	0	1.3612e-06	0.000308642	1.28558e-05	14	29									
MAFB	9935	broad.mit.edu	37	20	39316580	39316580	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:39316580G>A	uc002xji.2	-	1	1297	c.911C>T	c.(910-912)TCC>TTC	p.S304F		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	304					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CCTGAAGCCGGAGTTGGCGAG	0.527		NaN	T	IGH@	MM								0	0	0	0.000958276	0	19	105									
EDN3	1908	broad.mit.edu	37	20	57875894	57875894	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:57875894C>T	uc002yap.2	+	1	396	c.27C>T	c.(25-27)TTC>TTT	p.F9F	EDN3_uc002yao.1_Silent_p.F9F|EDN3_uc002yaq.2_Silent_p.F9F|EDN3_uc002yar.2_Silent_p.F9F|EDN3_uc002yas.2_Silent_p.F9F	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	9					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					GGCTCCTTTTCGGGCTCACAG	0.721		NaN											0	0	0	0.000308642	0	12	22									
POTEH	23784	broad.mit.edu	37	22	16287731	16287731	+	Missense_Mutation	SNP	G	G	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr22:16287731G>T	uc010gqp.2	-	1	207	c.155C>A	c.(154-156)TCT>TAT	p.S52Y	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Translation_Start_Site	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	52										skin(1)	1						CTTCATAGCAGAATCGTCGTG	0.612		NaN											1	0	5.96743e-59	0.000781405	6.17499e-58	87	442									
TOB2	10766	broad.mit.edu	37	22	41833080	41833080	+	Silent	SNP	C	C	T	rs61756254		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr22:41833080C>T	uc003azz.1	-	2	977	c.270G>A	c.(268-270)CTG>CTA	p.L90L		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	90					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1						TCCAGACACTCAGCTCCTCAG	0.597		NaN											0	0	0	0.000589545	0	40	88									
SRGAP3	9901	broad.mit.edu	37	3	9032407	9032407	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:9032407C>T	uc003brf.1	-	21	3351	c.2675G>A	c.(2674-2676)TGC>TAC	p.C892Y	SRGAP3_uc003brg.1_Missense_Mutation_p.C868Y	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	892					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GCTGCTGGGGCAGGCAGCAGC	0.697		NaN	T	RAF1	pilocytic astrocytoma								0	0	0	0.00010058	0	12	18									
ZNF167	55888	broad.mit.edu	37	3	44598778	44598778	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:44598778G>A	uc010hin.2	+	2	627	c.239G>A	c.(238-240)CGC>CAC	p.R80H	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Missense_Mutation_p.R80H|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.R80H|ZNF167_uc003cnk.2_Missense_Mutation_p.R80H	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	80	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GAGCTCTGCCGCTGGTGGCTC	0.607		NaN											0	0	0	0.000151284	0	14	38									
CACNA2D2	9254	broad.mit.edu	37	3	50414954	50414954	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:50414954C>T	uc003daq.2	-	17	1608	c.1570G>A	c.(1570-1572)GTG>ATG	p.V524M	CACNA2D2_uc003dap.2_Missense_Mutation_p.V524M	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	524	Cache.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	ATGCCCATCACGCCCAGGATC	0.602		NaN											0	0	0	0.000673444	0	11	24									
BOC	91653	broad.mit.edu	37	3	112998756	112998756	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:112998756G>A	uc003dzx.2	+	13	2727	c.2106G>A	c.(2104-2106)TCG>TCA	p.S702S	BOC_uc003dzy.2_Silent_p.S702S|BOC_uc003dzz.2_Silent_p.S703S|BOC_uc003eab.2_Silent_p.S403S|BOC_uc003eac.2_Silent_p.S17S	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	702	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			ACGTGGTGTCGGGCTACAGCG	0.607		NaN											0	0	0	0.000589545	0	46	81									
KIAA1407	57577	broad.mit.edu	37	3	113753924	113753924	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:113753924C>T	uc003eax.2	-	6	813	c.666G>A	c.(664-666)TCG>TCA	p.S222S	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Silent_p.S200S|KIAA1407_uc011bip.1_Silent_p.S209S	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	222	Potential.									ovary(2)	2						CCAAGAAGGCCGATTTTTTCA	0.423		NaN											0	0	0	0.000586117	0	26	69									
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.000422831	0	16	42									
KLHL8	57563	broad.mit.edu	37	4	88099702	88099702	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr4:88099702G>A	uc011cdb.1	-	5	1408	c.1023C>T	c.(1021-1023)ATC>ATT	p.I341I	KLHL8_uc003hql.1_Silent_p.I341I|KLHL8_uc003hqm.1_Silent_p.I265I|KLHL8_uc003hqn.1_Silent_p.I158I|KLHL8_uc010ikj.1_5'UTR	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	341	Kelch 1.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TGTTTTTGTTGATAGAATAGC	0.428		NaN											0	0	0	0.000442599	0	8	64									
FGA	2243	broad.mit.edu	37	4	155506820	155506820	+	Silent	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr4:155506820C>G	uc003iod.1	-	5	1819	c.1761G>C	c.(1759-1761)ACG>ACC	p.T587T	FGA_uc003ioe.1_Silent_p.T587T|FGA_uc003iof.1_3'UTR	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	587	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TGTTGTAACTCGTGCTACTAG	0.433		NaN											0	0	0	0.000878237	0	27	49									
TLL1	7092	broad.mit.edu	37	4	166795194	166795194	+	Missense_Mutation	SNP	G	G	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr4:166795194G>C	uc003irh.1	+	1	785	c.138G>C	c.(136-138)GAG>GAC	p.E46D	TLL1_uc011cjn.1_Missense_Mutation_p.E46D|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	46					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATAAAACAGAGACTATAGATT	0.577		NaN											0	0	0	0.000781405	0	94	177									
DNAH5	1767	broad.mit.edu	37	5	13814929	13814929	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:13814929C>T	uc003jfd.2	-	43	7057	c.7015G>A	c.(7015-7017)GGT>AGT	p.G2339S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2339	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTACTGGACCATCAAGAATT	0.383		NaN							Kartagener_syndrome				0	0	0	0.000151284	0	13	24									
SKIV2L2	23517	broad.mit.edu	37	5	54674240	54674240	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:54674240G>A	uc003jpy.3	+	17	2175	c.1909G>A	c.(1909-1911)GGT>AGT	p.G637S	SKIV2L2_uc011cqi.1_Missense_Mutation_p.G536S	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	637					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGCCAAATTGGGTAAAGAAAT	0.308		NaN											0	0	0	0.000375601	0	23	69									
PCDHA7	56141	broad.mit.edu	37	5	140215322	140215322	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:140215322G>A	uc003lhq.2	+	1	1354	c.1354G>A	c.(1354-1356)GCC>ACC	p.A452T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A452T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACAACGCCCCGGCGTT	0.677		NaN											0	0	0	0.000781405	0	50	99									
PCDHA7	56141	broad.mit.edu	37	5	140215822	140215822	+	Silent	SNP	G	G	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:140215822G>C	uc003lhq.2	+	1	1854	c.1854G>C	c.(1852-1854)GCG>GCC	p.A618A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.A618A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	618	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCCGGTGCGAGCATCCCGT	0.637		NaN											0	0	0	0.000589545	0	41	92									
PCDHGB6	56100	broad.mit.edu	37	5	140787909	140787909	+	Missense_Mutation	SNP	T	T	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:140787909T>A	uc003lkj.1	+	1	140	c.140T>A	c.(139-141)GTG>GAG	p.V47E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.V47E	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	47	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTCGGTGGTGGGGAACCTC	0.592		NaN											0	0	0	0.000132079	0	20	55									
DBN1	1627	broad.mit.edu	37	5	176885084	176885084	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:176885084T>C	uc003mgy.2	-	12	1923	c.1751A>G	c.(1750-1752)GAG>GGG	p.E584G	DBN1_uc011dga.1_Missense_Mutation_p.E316G|DBN1_uc003mgx.2_Missense_Mutation_p.E586G|DBN1_uc010jkn.1_Missense_Mutation_p.E534G|DBN1_uc003mgz.1_Missense_Mutation_p.E567G	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	584					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGTGGTCTCGCCATTGGT	0.682		NaN											0	0	0	0.000339439	0	31	88									
HIVEP1	3096	broad.mit.edu	37	6	12124529	12124529	+	Missense_Mutation	SNP	A	A	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:12124529A>C	uc003nac.2	+	4	4680	c.4501A>C	c.(4501-4503)ACC>CCC	p.T1501P	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1501					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTCCAGCTCTACCAACGTTTT	0.438		NaN											0	0	0	0.00106085	0	27	40									
HIST1H2BG	8339	broad.mit.edu	37	6	26216573	26216573	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:26216573C>T	uc003ngz.2	-	1	300	c.299G>A	c.(298-300)CGT>CAT	p.R100H	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	100					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				AAGCAGCAGACGCACGGCGGT	0.567		NaN											0	0	0	0.000878237	0	26	148									
HLA-F	3134	broad.mit.edu	37	6	29694776	29694776	+	Silent	SNP	C	C	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:29694776C>A	uc003nno.3	+	7	1277	c.1153C>A	c.(1153-1155)CGG>AGG	p.R385R	HLA-F_uc011dlx.1_Silent_p.R385R|HLA-F_uc011dly.1_RNA|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						CTTGGGCCGCCGGAAGGTGGG	0.512		NaN											1	0	1.50039e-11	0.000229342	1.48789e-10	21	244									
HLA-C	3107	broad.mit.edu	37	6	31239532	31239532	+	Missense_Mutation	SNP	C	C	T	rs41543115		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:31239532C>T	uc003nsy.2	-	2	194	c.187G>A	c.(187-189)GAC>AAC	p.D63N	HLA-C_uc011dnj.1_Missense_Mutation_p.D35N|HLA-C_uc003nsx.2_5'UTR|HLA-C_uc003nsz.2_Missense_Mutation_p.D63N|HLA-C_uc010jsl.2_Missense_Mutation_p.D63N|HLA-C_uc003nta.2_Missense_Mutation_p.D63N|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_5'UTR|HLA-B_uc003ntf.2_Intron	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	63	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						CTCGCGGCGTCGCTGTCGAAC	0.687		NaN											0	0	0	0.000781405	0	63	50									
HSPA1A	3303	broad.mit.edu	37	6	31785219	31785219	+	Silent	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:31785219C>T	uc003nxj.2	+	1	1929	c.1686C>T	c.(1684-1686)ATC>ATT	p.I562I	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc011doj.1_Silent_p.I325I|HSPA1A_uc003nxi.1_Silent_p.I397I|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	562					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						AGGGCAAGATCAGCGAGGCGG	0.587		NaN											0	0	0	0.000781405	0	53	64									
EPHA7	2045	broad.mit.edu	37	6	93955099	93955099	+	Silent	SNP	T	T	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:93955099T>C	uc003poe.2	-	16	3040	c.2799A>G	c.(2797-2799)CAA>CAG	p.Q933Q	EPHA7_uc003pof.2_Silent_p.Q928Q|EPHA7_uc011eac.1_Silent_p.Q929Q	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	933	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TCTTAATAGCTTGTAGCCATT	0.378		NaN											0	0	0	0.000227799	0	29	78									
HACE1	57531	broad.mit.edu	37	6	105225170	105225170	+	Nonsense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:105225170C>T	uc003pqu.1	-	15	1866	c.1589G>A	c.(1588-1590)TGG>TAG	p.W530*	HACE1_uc010kcy.1_Nonsense_Mutation_p.W12*|HACE1_uc010kcz.1_Intron|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Nonsense_Mutation_p.W183*	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	530					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TTCATAGAACCATTCACAGCG	0.373		NaN											0	0	0	0.000781405	0	48	99									
CREB5	9586	broad.mit.edu	37	7	28843821	28843821	+	Silent	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr7:28843821G>A	uc003szq.2	+	8	1098	c.708G>A	c.(706-708)TTG>TTA	p.L236L	CREB5_uc003szo.2_Silent_p.L203L|CREB5_uc003szr.2_Silent_p.L229L|CREB5_uc003szs.2_Silent_p.L97L	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	236					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						TTCAGAGGTTGAAGGCTGCAT	0.453		NaN											0	0	0	0.00058488	0	33	43									
ASB4	51666	broad.mit.edu	37	7	95157438	95157438	+	Silent	SNP	C	C	T	rs142833028		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr7:95157438C>T	uc011kij.1	+	3	801	c.801C>T	c.(799-801)CTC>CTT	p.L267L	ASB4_uc003unx.2_Silent_p.L267L	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	267	ANK 6.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			ACCACGTGCTCATGCACATGA	0.562		NaN									OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000175454	0	22	42									
DOCK4	9732	broad.mit.edu	37	7	111422965	111422965	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr7:111422965C>T	uc003vfx.2	-	34	3782	c.3513G>A	c.(3511-3513)ATG>ATA	p.M1171I	DOCK4_uc011kml.1_Missense_Mutation_p.M52I|DOCK4_uc011kmm.1_Missense_Mutation_p.M78I|DOCK4_uc003vfw.2_Missense_Mutation_p.M621I|DOCK4_uc003vfy.2_Missense_Mutation_p.M1216I	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1171	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTACCTCTCCCATTTTCATGC	0.373		NaN											0	0	0	0.000509022	0	41	108									
TGS1	96764	broad.mit.edu	37	8	56711557	56711557	+	Missense_Mutation	SNP	G	G	A			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr8:56711557G>A	uc003xsj.3	+	8	2014	c.1627G>A	c.(1627-1629)GCT>ACT	p.A543T	TGS1_uc010lyh.2_Missense_Mutation_p.A447T	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	543					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGTGCACGACGCTTCCACAAG	0.388		NaN											0	0	0	0.00047179	0	23	48									
C8orf45	157777	broad.mit.edu	37	8	67786681	67786681	+	Missense_Mutation	SNP	T	T	C			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr8:67786681T>C	uc003xwz.3	+	3	386	c.215T>C	c.(214-216)GTC>GCC	p.V72A	C8orf45_uc003xwv.2_Missense_Mutation_p.V72A|C8orf45_uc011lev.1_Missense_Mutation_p.V72A|C8orf45_uc011lew.1_Intron|C8orf45_uc011lex.1_5'UTR|C8orf45_uc003xwy.3_Missense_Mutation_p.V72A	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	72					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCTGCTGAAGTCTTTCAATCA	0.303		NaN											0	0	0	0.000279167	0	28	61									
CDKN2B	1030	broad.mit.edu	37	9	22008871	22008871	+	Missense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:22008871C>G	uc003zpo.2	-	1	442	c.82G>C	c.(82-84)GAG>CAG	p.E28Q	MTAP_uc003zpi.1_Intron|CDKN2BAS_uc010miw.1_Intron|CDKN2BAS_uc010mix.1_Intron|CDKN2BAS_uc003zpm.2_Intron|CDKN2B_uc003zpn.2_Missense_Mutation_p.E28Q	NM_004936	NP_004927	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B isoform 1	28	ANK 1; truncated.				cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CGCACCTTCTCCACTAGTCCC	0.716		NaN							Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System		OREG0019127	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000274275	0	9	16									
ASPN	54829	broad.mit.edu	37	9	95219645	95219645	+	Nonsense_Mutation	SNP	G	G	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:95219645G>T	uc004ase.1	-	8	1312	c.1068C>A	c.(1066-1068)TAC>TAA	p.Y356*	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_3'UTR	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	356	LRR 10.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						GCATTTCCCAGTATTTCACCG	0.378		NaN											1	0	4.35082e-09	0.000175454	4.24383e-08	20	39									
STXBP1	6812	broad.mit.edu	37	9	130438119	130438119	+	Missense_Mutation	SNP	A	A	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:130438119A>T	uc004brl.2	+	14	1344	c.1147A>T	c.(1147-1149)ATC>TTC	p.I383F	STXBP1_uc004brk.2_Missense_Mutation_p.I383F	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	383					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						GGGAGAGAAGATCAAGGACCC	0.488		NaN											0	0	0	0.000151284	0	12	40									
CCBL1	883	broad.mit.edu	37	9	131600026	131600026	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:131600026C>T	uc004bwh.2	-	6	690	c.505G>A	c.(505-507)GGC>AGC	p.G169S	CCBL1_uc004bwf.2_Missense_Mutation_p.G203S|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.G169S|CCBL1_uc004bwj.2_Missense_Mutation_p.G119S|CCBL1_uc011mbl.1_Missense_Mutation_p.G263S|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Intron	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	169					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	GTGAATTTGCCGGCCAGCTCC	0.622		NaN											0	0	0	0.000308642	0	13	127									
IQSEC2	23096	broad.mit.edu	37	X	53283763	53283763	+	Silent	SNP	A	A	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:53283763A>G	uc004dsd.2	-	4	1551	c.1350T>C	c.(1348-1350)TCT>TCC	p.S450S	IQSEC2_uc004dsc.2_Silent_p.S245S	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	440					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						AAAACTCTCCAGATGTGGTGA	0.572		NaN											0	0	0	0.000184323	0	27	30									
EFNB1	1947	broad.mit.edu	37	X	68060145	68060145	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:68060145C>T	uc004dxd.3	+	5	1469	c.689C>T	c.(688-690)CCT>CTT	p.P230L	EFNB1_uc004dxe.2_Missense_Mutation_p.P230L	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	230	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						AGCGGGGACCCTGATGGCTTC	0.582		NaN											0	0	0	8.12818e-05	0	6	31									
SLC6A14	11254	broad.mit.edu	37	X	115584268	115584268	+	Missense_Mutation	SNP	C	C	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:115584268C>T	uc004eqi.2	+	9	1350	c.1246C>T	c.(1246-1248)CTT>TTT	p.L416F		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	416	Helical; Name=8; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTTTTTCATGCTTTTAACTTT	0.378		NaN											0	0	0	0.000720815	0	26	11									
LONRF3	79836	broad.mit.edu	37	X	118109240	118109240	+	Nonsense_Mutation	SNP	C	C	G			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:118109240C>G	uc004eqw.2	+	1	528	c.497C>G	c.(496-498)TCA>TGA	p.S166*	LONRF3_uc004eqx.2_Nonsense_Mutation_p.S166*|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_5'Flank	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	166	RING-type 1.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						GGGTTTCTATCAGACCCCGTG	0.672		NaN											0	0	0	0.00047179	0	21	6									
ARID1A	8289	broad.mit.edu	37	1	27102153	27102153	+	Frame_Shift_Del	DEL	C	C	-			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:27102153delC	uc001bmv.1	+	19	5452	c.5079delC	c.(5077-5079)ATCfs	p.I1693fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.I1692fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.I1476fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.I539fs|ARID1A_uc009vsm.1_Frame_Shift_Del_p.I21fs|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1693					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCATCAACATCCTGCTGTATG	0.498		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								NaN	NaN	NaN	NaN	NaN	27	59	---	---							
CNTNAP4	85445	broad.mit.edu	37	16	76481915	76481915	+	Frame_Shift_Del	DEL	A	A	-			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:76481915delA	uc002feu.1	+	7	930	c.545delA	c.(544-546)GAAfs	p.E182fs	CNTNAP4_uc002fev.1_Frame_Shift_Del_p.E94fs|CNTNAP4_uc010chb.1_Frame_Shift_Del_p.E157fs|CNTNAP4_uc002fex.1_Frame_Shift_Del_p.E185fs|CNTNAP4_uc002few.2_Frame_Shift_Del_p.E157fs	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	182	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CTAGGATCAGAAGTGGTTGAT	0.308		NaN											NaN	NaN	NaN	NaN	NaN	21	69	---	---							
PTRF	284119	broad.mit.edu	37	17	40556948	40556949	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:40556948_40556949delGC	uc002hzo.2	-	2	1088_1089	c.929_930delGC	c.(928-930)CGCfs	p.R310fs	PTRF_uc010wgi.1_Frame_Shift_Del_p.R292fs	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	310					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CGGTCTTGGAGCGCGCGTACAC	0.649		NaN											NaN	NaN	NaN	NaN	NaN	26	94	---	---							
QPCT	25797	broad.mit.edu	37	2	37596833	37596834	+	Frame_Shift_Ins	INS	-	-	T			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:37596833_37596834insT	uc002rqg.2	+	5	851_852	c.729_730insT	c.(727-732)TTATTGfs	p.L243fs	QPCT_uc002rqh.2_Frame_Shift_Ins_p.L194fs	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	243_244					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				CTCAGGATTTATTGGTCTTATT	0.366		NaN											NaN	NaN	NaN	NaN	NaN	31	70	---	---							
TLE4	7091	broad.mit.edu	37	9	82267521	82267521	+	Frame_Shift_Del	DEL	C	C	-			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:82267521delC	uc004ald.2	+	7	1232	c.383delC	c.(382-384)GCCfs	p.A128fs	TLE4_uc004alc.2_Frame_Shift_Del_p.A135fs|TLE4_uc010mpr.2_Frame_Shift_Del_p.A14fs|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Frame_Shift_Del_p.A103fs|TLE4_uc010mps.2_Frame_Shift_Del_p.A128fs|TLE4_uc004alf.2_Frame_Shift_Del_p.A74fs	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CAACTCCAGGCCCAGCATTTA	0.532		NaN											NaN	NaN	NaN	NaN	NaN	70	174	---	---