Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CHD5	26038	broad.mit.edu	37	1	6188917	6188917	+	Silent	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:6188917G>C	uc001amb.1	-	23	3700	c.3600C>G	c.(3598-3600)CTC>CTG	p.L1200L	CHD5_uc001alz.1_Silent_p.L57L|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1200					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGTCCTTGAAGAGTTCCTCCG	0.667		NaN											0	0	0	0.248553	0	6	69									
MASP2	10747	broad.mit.edu	37	1	11105485	11105485	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:11105485C>T	uc001aru.2	-	4	545	c.524G>A	c.(523-525)CGT>CAT	p.R175H	MASP2_uc001arv.2_Missense_Mutation_p.R175H|MASP2_uc001arw.2_3'UTR|MASP2_uc001arx.1_Missense_Mutation_p.R175H	NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	175	EGF-like; calcium-binding.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GCGCTTGTTACGGTGCAGGAC	0.687		NaN											0	0	0	0.788014	0	29	47									
UBR4	23352	broad.mit.edu	37	1	19491418	19491418	+	Silent	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:19491418C>T	uc001bbi.2	-	32	4390	c.4386G>A	c.(4384-4386)GTG>GTA	p.V1462V	UBR4_uc001bbm.1_Silent_p.V673V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1462					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCTGCAGGCGCACAGGTTCCA	0.577		NaN											0	0	0	0.435327	0	11	59									
MACF1	23499	broad.mit.edu	37	1	39801075	39801075	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:39801075C>G	uc010oiu.1	+	1	4266	c.4135C>G	c.(4135-4137)CAA>GAA	p.Q1379E	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2944					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGAGAAAATCAAGGGGAAGT	0.378		NaN											0	0	0	0.361761	0	8	81									
KCNQ4	9132	broad.mit.edu	37	1	41285143	41285143	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:41285143C>T	uc001cgh.1	+	5	915	c.833C>T	c.(832-834)ACG>ATG	p.T278M	KCNQ4_uc001cgi.1_Missense_Mutation_p.T278M	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	278					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TGGTGGGGGACGGTGCGTGAG	0.627		NaN											0	0	0	0.361761	0	9	149									
ZFYVE9	9372	broad.mit.edu	37	1	52740153	52740153	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:52740153C>G	uc001cto.2	+	8	2815	c.2643C>G	c.(2641-2643)TTC>TTG	p.F881L	ZFYVE9_uc001ctp.2_Missense_Mutation_p.F822L	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	881					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TTTGTCTATTCTCTGGGAGTA	0.398		NaN											0	0	0	0.307466	0	6	190									
INADL	10207	broad.mit.edu	37	1	62614061	62614061	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:62614061G>C	uc001dab.2	+	42	5491	c.5377G>C	c.(5377-5379)GAG>CAG	p.E1793Q	INADL_uc001dac.2_RNA|INADL_uc009wag.2_Missense_Mutation_p.E577Q	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1793					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AGAAGACACAGAGTGAGTATT	0.478		NaN											0	0	0	0.819951	0	35	95									
TNNI3K	51086	broad.mit.edu	37	1	74954930	74954930	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:74954930G>A	uc001dgf.1	+	22	2230	c.2179G>A	c.(2179-2181)GAG>AAG	p.E727K	TNNI3K_uc001dge.1_Missense_Mutation_p.E828K	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	727						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						CTGCAACATTGAGGTAAAAGC	0.373		NaN											0	0	0	0.217242	0	6	63									
ZNHIT6	54680	broad.mit.edu	37	1	86173471	86173471	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:86173471T>C	uc001dlh.2	-	1	631	c.497A>G	c.(496-498)AAG>AGG	p.K166R	ZNHIT6_uc010osc.1_Missense_Mutation_p.K127R	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	166	Glu-rich.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						ACCAACAAACTTCTCCTCCTG	0.408		NaN											0	0	0	0.819951	0	29	237									
C1orf183	55924	broad.mit.edu	37	1	112269624	112269624	+	Missense_Mutation	SNP	G	G	A	rs112881255		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:112269624G>A	uc001ebo.1	-	2	1018	c.860C>T	c.(859-861)TCA>TTA	p.S287L	C1orf183_uc001ebp.1_Missense_Mutation_p.S272L	NM_019099	NP_061972	Q9NTI7	CA183_HUMAN	hypothetical protein LOC55924 isoform 1	287										ovary(2)	2		all_cancers(81;7.29e-06)|all_epithelial(167;4.98e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.16e-05)		Lung(183;0.0155)|Colorectal(144;0.0289)|all cancers(265;0.0592)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0852)|COAD - Colon adenocarcinoma(174;0.113)		ATCAAATCCTGAGGGTGAGTG	0.597		NaN											0	0	0	0.859065	0	34	310									
AMPD1	270	broad.mit.edu	37	1	115220970	115220970	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:115220970G>C	uc001efe.1	-	8	1160	c.1076C>G	c.(1075-1077)TCT>TGT	p.S359C	AMPD1_uc001eff.1_Missense_Mutation_p.S355C	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	359					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AACATCCAGAGAATCAACAGT	0.428		NaN											0	0	0	0.639603	0	19	150									
LYSMD1	388695	broad.mit.edu	37	1	151134376	151134376	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:151134376C>G	uc001ewy.2	-	2	1017	c.381G>C	c.(379-381)GAG>GAC	p.E127D	LYSMD1_uc010pcr.1_Missense_Mutation_p.E79D	NM_212551	NP_997716	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain	127					cell wall macromolecule catabolic process						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGCTCCTGTCTCTTGTTTCT	0.507		NaN											0	0	0	0.335167	0	10	70									
FLG	2312	broad.mit.edu	37	1	152282758	152282758	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:152282758G>C	uc001ezu.1	-	3	4640	c.4604C>G	c.(4603-4605)TCA>TGA	p.S1535*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1535	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGGGTCCTGACTGCCCATG	0.567		NaN							Ichthyosis				0	0	0	0.870114	0	47	377									
SEMA4A	64218	broad.mit.edu	37	1	156131202	156131202	+	Silent	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:156131202C>G	uc001fnl.2	+	9	980	c.876C>G	c.(874-876)CTC>CTG	p.L292L	SEMA4A_uc009wrq.2_Silent_p.L292L|SEMA4A_uc001fnm.2_Silent_p.L292L|SEMA4A_uc001fnn.2_Silent_p.L160L|SEMA4A_uc001fno.2_Silent_p.L292L	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	292	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCCAGCTGCTCTGCACCCAGC	0.667		NaN											0	0	0	0.520397	0	16	102									
PAPPA2	60676	broad.mit.edu	37	1	176564215	176564215	+	Missense_Mutation	SNP	C	C	T	rs116090626	by1000genomes	TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:176564215C>T	uc001gkz.2	+	3	2639	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	PAPPA2_uc001gky.1_Missense_Mutation_p.S492L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	492	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAGATTCTGTCGCCTTTGCAG	0.522		NaN											0	0	0	0.608945	0	21	35									
TLR5	7100	broad.mit.edu	37	1	223284277	223284277	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:223284277G>T	uc001hnv.1	-	4	2543	c.2097C>A	c.(2095-2097)TTC>TTA	p.F699L	TLR5_uc001hnw.1_Missense_Mutation_p.F699L	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	699	Cytoplasmic (Potential).|TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		CTTTGCTGCTGAAGCACAAAT	0.438		NaN											1	0	0.000602214	0.184627	0.000619927	4	90									
FBXO28	23219	broad.mit.edu	37	1	224318184	224318184	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:224318184G>C	uc001hoh.2	+	2	319	c.278G>C	c.(277-279)AGA>ACA	p.R93T	FBXO28_uc009xef.2_Missense_Mutation_p.R93T|FBXO28_uc010pvc.1_5'UTR	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	93	F-box.									ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		GTTTGTAAAAGAATGGACTTG	0.373		NaN											0	0	0	0.307466	0	8	74									
RYR2	6262	broad.mit.edu	37	1	237947659	237947659	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:237947659C>T	uc001hyl.1	+	90	12767	c.12647C>T	c.(12646-12648)GCG>GTG	p.A4216V	RYR2_uc010pya.1_Missense_Mutation_p.A631V	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4216					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGAGGTCAGCGAATAAGGAA	0.542		NaN											0	0	0	0.729181	0	25	40									
GDF2	2658	broad.mit.edu	37	10	48414152	48414152	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:48414152G>A	uc001jfa.1	-	2	879	c.716C>T	c.(715-717)ACG>ATG	p.T239M		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	239					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GATGTCCAGCGTGTCGCAGCC	0.582		NaN											0	0	0	0.639603	0	24	36									
PPP3CB	5532	broad.mit.edu	37	10	75214224	75214224	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:75214224G>C	uc001jue.2	-	10	1267	c.1132C>G	c.(1132-1134)CTG>GTG	p.L378V	PPP3CB_uc001juf.2_Missense_Mutation_p.L378V|PPP3CB_uc001jug.2_Missense_Mutation_p.L378V|PPP3CB_uc001jui.2_Missense_Mutation_p.L396V|PPP3CB_uc001juh.2_Missense_Mutation_p.L292V|PPP3CB_uc010qkj.1_Missense_Mutation_p.L6V	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	378										skin(1)	1	Prostate(51;0.0119)					CAAATACTCAGAACATTTACC	0.303		NaN											0	0	0	0.435327	0	10	110									
KIF20B	9585	broad.mit.edu	37	10	91511157	91511157	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:91511157A>G	uc001kgs.1	+	24	4223	c.4151A>G	c.(4150-4152)CAG>CGG	p.Q1384R	KIF20B_uc001kgr.1_Missense_Mutation_p.Q1344R|KIF20B_uc001kgt.1_Missense_Mutation_p.Q595R|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1384					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						CTAGAAGAACAGGAACAAACT	0.358		NaN											0	0	0	0.769981	0	27	223									
UBTD1	80019	broad.mit.edu	37	10	99327844	99327844	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:99327844G>A	uc001knv.1	+	2	437	c.244G>A	c.(244-246)GAC>AAC	p.D82N		NM_024954	NP_079230	Q9HAC8	UBTD1_HUMAN	ubiquitin domain containing 1	82											0		Colorectal(252;0.162)		Epithelial(162;3.04e-10)|all cancers(201;2.86e-08)		TGAAGCCAACGACCACGAGCT	0.637		NaN											0	0	0	0.870114	0	34	76									
INPP5F	22876	broad.mit.edu	37	10	121551496	121551496	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:121551496C>T	uc001leo.2	+	5	726	c.560C>T	c.(559-561)TCC>TTC	p.S187F	INPP5F_uc001len.3_Missense_Mutation_p.S187F	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	187	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CTGACCAATTCCGTGCAGAGG	0.507		NaN											0	0	0	0.750413	0	27	179									
UROS	7390	broad.mit.edu	37	10	127483469	127483469	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:127483469C>T	uc001liw.3	-	8	773	c.640G>A	c.(640-642)GAC>AAC	p.D214N	UROS_uc001liv.3_Missense_Mutation_p.D95N|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Missense_Mutation_p.D214N|UROS_uc001liy.3_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	214					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				TCGATATTGTCACCAGATAAC	0.373		NaN											0	0	0	0.335167	0	8	82									
HRAS	3265	broad.mit.edu	37	11	534288	534288	+	Missense_Mutation	SNP	C	C	T	rs104894230		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:534288C>T	uc001lpv.2	-	2	223	c.35G>A	c.(34-36)GGC>GAC	p.G12D	HRAS_uc010qvw.1_Missense_Mutation_p.G12D|HRAS_uc010qvx.1_Missense_Mutation_p.G12D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.870114	0	39	13									
OSBPL5	114879	broad.mit.edu	37	11	3147784	3147784	+	Silent	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:3147784C>T	uc001lxk.2	-	3	296	c.138G>A	c.(136-138)GGG>GGA	p.G46G	OSBPL5_uc010qxq.1_5'UTR|OSBPL5_uc009ydw.2_Silent_p.G46G|OSBPL5_uc001lxl.2_Silent_p.G46G|OSBPL5_uc009ydx.2_Silent_p.G70G|OSBPL5_uc001lxm.1_RNA	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	46					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCATGTCCTTCCCTGCAAGAG	0.667		NaN											0	0	0	0.184627	0	4	26									
DKK3	27122	broad.mit.edu	37	11	12030017	12030017	+	Missense_Mutation	SNP	A	A	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:12030017A>T	uc001mju.2	-	1	170	c.113T>A	c.(112-114)CTC>CAC	p.L38H	DKK3_uc010rcf.1_Missense_Mutation_p.L38H|DKK3_uc001mjv.2_Missense_Mutation_p.L38H|DKK3_uc001mjw.2_Missense_Mutation_p.L38H|DKK3_uc010rcg.1_Missense_Mutation_p.L38H|DKK3_uc001mjx.2_Missense_Mutation_p.L38H	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	38	O-glycosylated at one site.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		CGGGTAGCTGAGAGCCGGGCC	0.701		NaN											0	0	0	0.779181	0	30	5									
TEAD1	7003	broad.mit.edu	37	11	12946588	12946588	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:12946588G>C	uc001mkj.3	+	11	1623	c.958G>C	c.(958-960)GAA>CAA	p.E320Q	TEAD1_uc001mkk.3_Missense_Mutation_p.E239Q|TEAD1_uc009ygl.2_Missense_Mutation_p.E156Q	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	335	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GCAAGTAGTAGAAAAAGTAGA	0.433		NaN											0	0	0	0.115264	0	3	59									
KCNC1	3746	broad.mit.edu	37	11	17793941	17793941	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:17793941G>A	uc001mnk.3	+	2	1355	c.1300G>A	c.(1300-1302)GTC>ATC	p.V434I	KCNC1_uc009yhc.1_Missense_Mutation_p.V434I	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	434	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GCCCGTGCCCGTCATCGTGAA	0.577		NaN											0	0	0	0.539581	0	15	86									
SPRYD5	84767	broad.mit.edu	37	11	55658785	55658785	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:55658785C>T	uc010rip.1	+	7	1128	c.1036C>T	c.(1036-1038)CAT>TAT	p.H346Y	SPRYD5_uc010riq.1_Missense_Mutation_p.H203Y	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	346	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TTGGGAGGTTCATATGGGGGA	0.428		NaN											0	0	0	0.411799	0	12	96									
PCNXL3	399909	broad.mit.edu	37	11	65403111	65403111	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:65403111C>T	uc001oey.2	+	32	5296	c.5296C>T	c.(5296-5298)CGC>TGC	p.R1766C	PCNXL3_uc001oez.2_Missense_Mutation_p.R653C	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1766						integral to membrane					0						GCAGGCGCTTCGCAACATGAT	0.677		NaN											0	0	0	0.307466	0	8	21									
ABCC9	10060	broad.mit.edu	37	12	21958155	21958155	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:21958155C>T	uc001rfi.1	-	38	4623	c.4603G>A	c.(4603-4605)GCC>ACC	p.A1535T	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.A1499T|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1535	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTCTTGTGGGCGAGCAAATTT	0.438		NaN											0	0	0	0.335167	0	8	48									
SOX5	6660	broad.mit.edu	37	12	23699264	23699264	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:23699264C>G	uc001rfw.2	-	12	1685	c.1583G>C	c.(1582-1584)AGT>ACT	p.S528T	SOX5_uc001rfx.2_Missense_Mutation_p.S515T|SOX5_uc001rfy.2_Missense_Mutation_p.S407T|SOX5_uc001rfv.2_Missense_Mutation_p.S142T|SOX5_uc010siv.1_Missense_Mutation_p.S515T|SOX5_uc010siw.1_Intron|SOX5_uc001rfz.1_Missense_Mutation_p.S480T	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	528					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						AGAATCTCCACTCAGATTGAA	0.343		NaN											0	0	0	0.27861	0	7	109									
ERBB3	2065	broad.mit.edu	37	12	56478854	56478854	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:56478854G>A	uc001sjh.2	+	3	503	c.310G>A	c.(310-312)GTG>ATG	p.V104M	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45M|ERBB3_uc001sjg.2_Missense_Mutation_p.V104M	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517		NaN											0	0	0	0.870114	0	63	106									
ACSS3	79611	broad.mit.edu	37	12	81568654	81568654	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:81568654G>A	uc001szl.1	+	8	1277	c.1186G>A	c.(1186-1188)GCA>ACA	p.A396T	ACSS3_uc001szm.1_Missense_Mutation_p.A395T|ACSS3_uc001szn.1_Missense_Mutation_p.A78T	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	396						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AGCACCAACTGCAATTAGAGC	0.512		NaN											0	0	0	0.435327	0	14	46									
DDX51	317781	broad.mit.edu	37	12	132624237	132624237	+	Silent	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:132624237C>T	uc001ujy.3	-	14	1956	c.1917G>A	c.(1915-1917)CTG>CTA	p.L639L		NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	639	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		CCAGCGGCTGCAGCAGCTTGC	0.612		NaN											0	0	0	0.115264	0	3	30									
SLC7A7	9056	broad.mit.edu	37	14	23244697	23244697	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:23244697T>C	uc001wgr.3	-	7	1189	c.1051A>G	c.(1051-1053)ATC>GTC	p.I351V	SLC7A7_uc001wgs.3_Missense_Mutation_p.I351V|SLC7A7_uc001wgt.3_Missense_Mutation_p.I351V|SLC7A7_uc001wgu.3_Missense_Mutation_p.I351V|SLC7A7_uc001wgv.3_Missense_Mutation_p.I351V	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	351					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		TCAACATGGATCATGCAGATG	0.473		NaN											0	0	0	0.608945	0	20	107									
ARHGAP5	394	broad.mit.edu	37	14	32563175	32563175	+	Silent	SNP	A	A	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:32563175A>G	uc001wrl.2	+	2	3539	c.3300A>G	c.(3298-3300)AAA>AAG	p.K1100K	ARHGAP5_uc001wrm.2_Silent_p.K1100K|ARHGAP5_uc001wrn.2_Silent_p.K1100K|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1100					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CAATTTTCAAACAGAAGGGCT	0.383		NaN											0	0	0	0.788014	0	30	57									
ARF6	382	broad.mit.edu	37	14	50360895	50360895	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:50360895G>A	uc001wxg.3	+	2	1062	c.441G>A	c.(439-441)AGG>AGA	p.R147R		NM_001663	NP_001654	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	147					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding				0	all_epithelial(31;0.000822)|Breast(41;0.0117)					TTCGGGACAGGAACTGGTATG	0.542		NaN											0	0	0	0.307466	0	6	44									
KCNH5	27133	broad.mit.edu	37	14	63175164	63175164	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:63175164G>A	uc001xfx.2	-	11	2080	c.2029C>T	c.(2029-2031)CGT>TGT	p.R677C	KCNH5_uc001xfy.2_Missense_Mutation_p.S611L	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	677	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTGATCTTACGAAAGATGATC	0.458		NaN											0	0	0	0.115264	0	3	62									
MAP3K9	4293	broad.mit.edu	37	14	71199958	71199958	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:71199958C>T	uc001xmm.2	-	11	2128	c.2128G>A	c.(2128-2130)GAT>AAT	p.D710N	MAP3K9_uc010ttk.1_Missense_Mutation_p.D438N|MAP3K9_uc001xmk.2_Missense_Mutation_p.D443N|MAP3K9_uc001xml.2_Missense_Mutation_p.D724N	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	710					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GAGGGGCCATCGCCATCCTCT	0.433		NaN											0	0	0	0.361761	0	6	75									
EIF2B2	8892	broad.mit.edu	37	14	75470268	75470268	+	Missense_Mutation	SNP	G	G	A	rs17849324		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:75470268G>A	uc001xrc.1	+	3	381	c.299G>A	c.(298-300)AGC>AAC	p.S100N		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	100				RLHGRSD -> DSMDAAT (in Ref. 2; AAC42002).	cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		CATGGACGCAGCGACGAGAGT	0.527		NaN											0	0	0	0.834066	0	30	73									
SPTLC2	9517	broad.mit.edu	37	14	78023407	78023407	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:78023407G>A	uc001xub.2	-	7	1121	c.933C>T	c.(931-933)CTC>CTT	p.L311L		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	311						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CCACAAGGATGAGAATTTTCT	0.393		NaN											0	0	0	0.27861	0	5	60									
SPTLC2	9517	broad.mit.edu	37	14	78023409	78023409	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:78023409G>A	uc001xub.2	-	7	1119	c.931C>T	c.(931-933)CTC>TTC	p.L311F		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	311						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACAAGGATGAGAATTTTCTTC	0.393		NaN											0	0	0	0.248553	0	4	59									
KIF26A	26153	broad.mit.edu	37	14	104618365	104618365	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:104618365C>T	uc001yos.3	+	3	302	c.302C>T	c.(301-303)TCT>TTT	p.S101F		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	101					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCTTGCCTCTCTGCCCTGCTT	0.672		NaN											0	0	0	0.27861	0	6	53									
C15orf55	256646	broad.mit.edu	37	15	34647806	34647806	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:34647806G>A	uc001zif.2	+	7	1668	c.1513G>A	c.(1513-1515)GAT>AAT	p.D505N	C15orf55_uc010ucc.1_Missense_Mutation_p.D533N|C15orf55_uc010ucd.1_Missense_Mutation_p.D523N	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	505						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TGAAGATGGGGATGGGCGGCT	0.582		NaN	T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.335167	0	8	69									
C15orf55	256646	broad.mit.edu	37	15	34648553	34648553	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:34648553G>T	uc001zif.2	+	7	2415	c.2260G>T	c.(2260-2262)GAG>TAG	p.E754*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.E782*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.E772*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	754						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GTGTGTAACTGAGTATCAGGA	0.532		NaN	T	BRD3|BRD4	lethal midline carcinoma								1	0	0.00307968	0.27861	0.00314712	7	79									
VPS13C	54832	broad.mit.edu	37	15	62228840	62228840	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:62228840C>G	uc002agz.2	-	48	5785	c.5711G>C	c.(5710-5712)AGA>ACA	p.R1904T	VPS13C_uc002aha.2_Missense_Mutation_p.R1861T|VPS13C_uc002ahb.1_Missense_Mutation_p.R1904T|VPS13C_uc002ahc.1_Missense_Mutation_p.R1861T	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1904					protein localization					ovary(2)	2						TTTTCTCACTCTTACAGTCTC	0.348		NaN											0	0	0	0.335167	0	8	48									
C15orf32	145858	broad.mit.edu	37	15	93015655	93015655	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:93015655G>C	uc002brc.1	+	1	749	c.277G>C	c.(277-279)GAT>CAT	p.D93H	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	93										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			ctcacgagtggATGGTTTGAT	0.279		NaN											0	0	0	0.479597	0	12	63									
UQCRC2	7385	broad.mit.edu	37	16	21968590	21968590	+	Missense_Mutation	SNP	A	A	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr16:21968590A>C	uc002djx.2	+	2	204	c.68A>C	c.(67-69)AAA>ACA	p.K23T	UQCRC2_uc002djy.2_Missense_Mutation_p.K23T|UQCRC2_uc010bxa.2_RNA	NM_003366	NP_003357	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	23					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			large_intestine(2)	2				GBM - Glioblastoma multiforme(48;0.0264)		CCCAAAGTTAAAGCCACAGCT	0.448		NaN											0	0	0	0.779181	0	26	33									
CMIP	80790	broad.mit.edu	37	16	81712168	81712168	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr16:81712168G>A	uc002fgp.2	+	10	1395	c.1323G>A	c.(1321-1323)ATG>ATA	p.M441I	CMIP_uc002fgq.1_Missense_Mutation_p.M347I|CMIP_uc010vnq.1_Missense_Mutation_p.M254I|CMIP_uc002fgr.1_Missense_Mutation_p.M288I	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	407						cytoplasm|nucleus					0						GCAGCACCATGAGCATCGAGC	0.572		NaN											0	0	0	0.479597	0	13	17									
ACAP1	9744	broad.mit.edu	37	17	7240683	7240683	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:7240683G>C	uc002ggd.2	+	2	312	c.106G>C	c.(106-108)GAA>CAA	p.E36Q		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	36	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						GACCCGTCTGGAAAAGGTGAC	0.557		NaN											0	0	0	0.115264	0	3	107									
CRLF3	51379	broad.mit.edu	37	17	29119551	29119551	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:29119551C>T	uc002hfr.3	-	6	975	c.866G>A	c.(865-867)CGA>CAA	p.R289Q	CRLF3_uc010wbr.1_Missense_Mutation_p.R173Q	NM_015986	NP_057070	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	289					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm					0		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TATATTTCTTCGACTGCTCAG	0.418		NaN											0	0	0	0.870114	0	41	141									
PEX12	5193	broad.mit.edu	37	17	33903110	33903110	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:33903110G>A	uc002hjp.2	-	3	1387	c.771C>T	c.(769-771)TTC>TTT	p.F257F		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	257	Helical; (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGAACTGCAAGAAGAATACAC	0.468		NaN											0	0	0	0.812448	0	37	68									
CDK12	51755	broad.mit.edu	37	17	37687082	37687082	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:37687082C>T	uc010cvv.2	+	14	4572	c.3986C>T	c.(3985-3987)TCC>TTC	p.S1329F	CDK12_uc002hrw.3_Missense_Mutation_p.S1320F	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1329					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						ATGGAGTACTCCACCCGACCC	0.562		NaN								TCGA Ovarian(9;0.13)			0	0	0	0.870114	0	50	62									
TBKBP1	9755	broad.mit.edu	37	17	45787901	45787901	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:45787901G>A	uc002ilu.2	+	9	2606	c.1757G>A	c.(1756-1758)TGC>TAC	p.C586Y		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	586					innate immune response						0						ATCCGCAGCTGCCCCCTCTGC	0.602		NaN											0	0	0	0.150653	0	4	65									
CACNA1G	8913	broad.mit.edu	37	17	48699087	48699087	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:48699087C>G	uc002irk.1	+	35	6364	c.5992C>G	c.(5992-5994)CTA>GTA	p.L1998V	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Intron|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Intron|CACNA1G_uc002irq.1_Missense_Mutation_p.L1975V|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Intron|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Missense_Mutation_p.L1927V|CACNA1G_uc002iru.1_Missense_Mutation_p.L1964V|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Missense_Mutation_p.L1900V|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Intron|CACNA1G_uc002isf.1_Intron|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1998	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTCCTGCTCTCTAGCTCTGAC	0.522		NaN											0	0	0	0.307466	0	6	54									
WDR7	23335	broad.mit.edu	37	18	54547217	54547217	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr18:54547217C>G	uc002lgk.1	+	21	3558	c.3347C>G	c.(3346-3348)TCT>TGT	p.S1116C	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.S1083C	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1116										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		ATTTCTACATCTTACGAGGAA	0.358		NaN											0	0	0	0.217242	0	5	59									
PCSK4	54760	broad.mit.edu	37	19	1487828	1487828	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:1487828G>A	uc002ltb.1	-	5	611	c.549C>T	c.(547-549)TAC>TAT	p.Y183Y	PCSK4_uc002lta.2_Missense_Mutation_p.T25M	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	183	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCCGGGTCGTAGTCATTGA	0.692		NaN											0	0	0	0.150653	0	3	3									
SCAMP4	113178	broad.mit.edu	37	19	1924163	1924163	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:1924163G>C	uc002luj.2	+	7	677	c.570G>C	c.(568-570)TGG>TGC	p.W190C	SCAMP4_uc002luk.2_Missense_Mutation_p.W156C|SCAMP4_uc010dss.2_Missense_Mutation_p.W146C	NM_079834	NP_524558	Q969E2	SCAM4_HUMAN	secretory carrier membrane protein 4	190	Cytoplasmic (Potential).				protein transport	integral to membrane					0		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGACGGAGTGGAACACGGGCA	0.612		NaN											0	0	0	0.150653	0	4	26									
CYP4F2	8529	broad.mit.edu	37	19	16008382	16008382	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:16008382C>G	uc002nbs.1	-	2	90	c.40G>C	c.(40-42)GTG>CTG	p.V14L	CYP4F2_uc010xot.1_Intron|CYP4F2_uc010xou.1_5'UTR	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	14					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GATGCTGCCACTGGCCAGAGG	0.672		NaN											0	0	0	0.38729	0	11	46									
ACTN4	81	broad.mit.edu	37	19	39200089	39200089	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:39200089G>A	uc002oja.1	+	7	765	c.706G>A	c.(706-708)GAC>AAC	p.D236N	ACTN4_uc010egc.1_Missense_Mutation_p.D236N	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	236	Actin-binding.|CH 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GAAATACCTCGACATCCCCAA	0.557		NaN											0	0	0	0.592651	0	17	81									
FBXO27	126433	broad.mit.edu	37	19	39516171	39516171	+	Missense_Mutation	SNP	G	G	C	rs151102214		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:39516171G>C	uc002okh.2	-	6	814	c.732C>G	c.(730-732)ATC>ATG	p.I244M		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	244	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CGCCCATCTTGATGTTGGAGA	0.572		NaN											0	0	0	0.115264	0	3	52									
ERCC2	2068	broad.mit.edu	37	19	45854898	45854898	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:45854898G>C	uc002pbj.2	-	23	2319	c.2272C>G	c.(2272-2274)CAG>GAG	p.Q758E	ERCC2_uc002pbh.2_Missense_Mutation_p.Q321E|ERCC2_uc002pbi.2_Missense_Mutation_p.Q451E|ERCC2_uc010ejz.2_Missense_Mutation_p.Q680E	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	758					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CAGAGCTGCTGAGCAATCTGC	0.592		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.870114	0	39	283									
ZNF808	388558	broad.mit.edu	37	19	53056856	53056856	+	Silent	SNP	A	A	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:53056856A>G	uc010epq.1	+	5	864	c.687A>G	c.(685-687)AAA>AAG	p.K229K	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TGAGAGAAAAATCTTTCCCAT	0.373		NaN											0	0	0	0.150653	0	4	229									
VN1R4	317703	broad.mit.edu	37	19	53770826	53770826	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:53770826G>A	uc010ydu.1	-	1	93	c.93C>T	c.(91-93)TCC>TCT	p.S31S		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	31	Cytoplasmic (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		TGCAGTAAAAGGAGAGATAAT	0.507		NaN								HNSCC(26;0.072)			0	0	0	0.217242	0	6	78									
ZNF776	284309	broad.mit.edu	37	19	58265941	58265941	+	Silent	SNP	T	T	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:58265941T>C	uc002qpx.2	+	3	1666	c.1443T>C	c.(1441-1443)ATT>ATC	p.I481I	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Silent_p.I481I	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	481	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		ATCAGCAGATTCACTCTGGAG	0.448		NaN											0	0	0	0.184627	0	3	111									
ITSN2	50618	broad.mit.edu	37	2	24521611	24521611	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:24521611G>C	uc002rfe.2	-	13	1675	c.1417C>G	c.(1417-1419)CAA>GAA	p.Q473E	ITSN2_uc002rff.2_Missense_Mutation_p.Q473E|ITSN2_uc002rfg.2_Missense_Mutation_p.Q473E|ITSN2_uc010eyd.2_Missense_Mutation_p.Q498E	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	473	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTATTCTTTTGATTGAGAAGC	0.368		NaN											0	0	0	0.457914	0	11	101									
AFTPH	54812	broad.mit.edu	37	2	64778744	64778744	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:64778744G>C	uc002sdc.2	+	1	168	c.136G>C	c.(136-138)GAT>CAT	p.D46H	AFTPH_uc002scz.2_Missense_Mutation_p.D46H|AFTPH_uc002sda.2_Missense_Mutation_p.D46H|AFTPH_uc002sdb.2_Missense_Mutation_p.D46H	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	46					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						AGGGTTTGTTGATTTCGATAC	0.408		NaN											0	0	0	0.870114	0	99	132									
LOC285033	285033	broad.mit.edu	37	2	96906235	96906235	+	Silent	SNP	T	T	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:96906235T>A	uc002svp.1	+	1	259	c.174T>A	c.(172-174)TCT>TCA	p.S58S	LOC285033_uc002svn.2_RNA|LOC285033_uc002svo.2_Silent_p.S135S	NM_001037228	NP_001032305	Q3KRF4	Q3KRF4_HUMAN	hypothetical protein LOC285033	58											0						TCAACTCTTCTCAGGACCAGA	0.537		NaN											0	0	0	0.27861	0	5	88									
ANKRD36	375248	broad.mit.edu	37	2	97869979	97869979	+	Missense_Mutation	SNP	G	G	T	rs111515821		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:97869979G>T	uc010yva.1	+	50	3284	c.3040G>T	c.(3040-3042)GAT>TAT	p.D1014Y	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1014											0						AGGAAAAAAGGATGGAGAAAA	0.289		NaN											1	0	0.004672	0.115264	0.00473971	3	9									
AFF3	3899	broad.mit.edu	37	2	100210557	100210557	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:100210557C>G	uc002tag.2	-	14	1802	c.1566G>C	c.(1564-1566)GAG>GAC	p.E522D	AFF3_uc002taf.2_Missense_Mutation_p.E547D|AFF3_uc010fiq.1_Missense_Mutation_p.E522D|AFF3_uc010yvr.1_Missense_Mutation_p.E675D|AFF3_uc002tah.1_Missense_Mutation_p.E547D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	522					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TGCTCTTGATCTCCTTCTCTC	0.602		NaN											0	0	0	0.248553	0	6	132									
LY75	4065	broad.mit.edu	37	2	160628465	160628465	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:160628465G>T	uc002ubb.3	-	39	5588	c.5519C>A	c.(5518-5520)TCT>TAT	p.S1840Y	LY75_uc010fos.2_Missense_Mutation_p.S1784Y|CD302_uc002uba.2_Missense_Mutation_p.S199Y|CD302_uc010zco.1_Missense_Mutation_p.S141Y	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		GGTGAAACGAGAATCAGAATG	0.368		NaN											1	0	2.42023e-17	0.779181	2.54761e-17	28	59									
PLA2R1	22925	broad.mit.edu	37	2	160808060	160808060	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:160808060C>G	uc002ube.1	-	24	3538	c.3331G>C	c.(3331-3333)GAT>CAT	p.D1111H	PLA2R1_uc010zcp.1_Missense_Mutation_p.D1111H|PLA2R1_uc002ubf.2_Missense_Mutation_p.D1111H	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1111	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GGATACATATCAGATGTATTT	0.363		NaN											0	0	0	0.115264	0	3	88									
SCN1A	6323	broad.mit.edu	37	2	166848014	166848014	+	Missense_Mutation	SNP	C	C	A	rs3749029		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:166848014C>A	uc010zcz.1	-	26	5756	c.5738G>T	c.(5737-5739)CGT>CTT	p.R1913L		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1924						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTGTAAGCACGCTGAATAAT	0.388		NaN											1	0	6.04164e-23	0.750413	6.4078e-23	28	64									
SF3B1	23451	broad.mit.edu	37	2	198265573	198265573	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:198265573C>T	uc002uue.2	-	18	2632	c.2584G>A	c.(2584-2586)GAA>AAA	p.E862K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	862	HEAT 7.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTGTACTGTTCGGCTTCATCT	0.373		NaN											0	0	0	0.479597	0	13	82									
GIGYF2	26058	broad.mit.edu	37	2	233710441	233710441	+	Splice_Site	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:233710441G>A	uc002vti.3	+	28	3643	c.3306_splice	c.e28-1	p.S1102_splice	GIGYF2_uc002vtj.3_Splice_Site_p.S1123_splice|GIGYF2_uc002vtk.3_Splice_Site_p.S1102_splice|GIGYF2_uc002vth.3_Splice_Site_p.S1096_splice|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc002vtq.3_Splice_Site_p.S435_splice	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTTTGCTTTAGTAAATCTGTA	0.353		NaN											0	0	0	0.520397	0	16	44									
RAE1	8480	broad.mit.edu	37	20	55929795	55929795	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr20:55929795G>A	uc002xyg.2	+	3	459	c.118G>A	c.(118-120)GAT>AAT	p.D40N	RAE1_uc010gis.1_Missense_Mutation_p.M1I|RAE1_uc010git.1_Missense_Mutation_p.D40N|RAE1_uc002xyh.2_Missense_Mutation_p.D40N|RAE1_uc002xyi.2_Missense_Mutation_p.D40N	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	40					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			ATCTCCTGATGATAGCATTGG	0.398		NaN											0	0	0	0.411799	0	9	89									
CDH4	1002	broad.mit.edu	37	20	60318751	60318751	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr20:60318751C>T	uc002ybn.1	+	3	316	c.302C>T	c.(301-303)ACG>ATG	p.T101M	CDH4_uc002ybo.1_RNA|CDH4_uc002ybp.1_Missense_Mutation_p.T27M	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	101					adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTGGCGTTCACGGTGACTGCA	0.607		NaN											0	0	0	0.217242	0	5	12									
AGPAT3	56894	broad.mit.edu	37	21	45401024	45401024	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr21:45401024G>A	uc002zdv.2	+	9	1220	c.998G>A	c.(997-999)GGA>GAA	p.G333E	AGPAT3_uc002zdw.2_Missense_Mutation_p.G333E|AGPAT3_uc002zdx.2_Missense_Mutation_p.G420E|AGPAT3_uc002zdy.2_Missense_Mutation_p.G271E	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	333	Helical; (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		TTTGCCAGCGGATCACCTCTC	0.572		NaN											0	0	0	0.479597	0	13	96									
HIC2	23119	broad.mit.edu	37	22	21800133	21800133	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:21800133A>G	uc002zur.3	+	3	1179	c.949A>G	c.(949-951)AGC>GGC	p.S317G	HIC2_uc002zus.3_Missense_Mutation_p.S317G	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	317					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CAACCACCTGAGCCTGCTGGA	0.657		NaN											0	0	0	0.248553	0	7	20									
DEPDC5	9681	broad.mit.edu	37	22	32241198	32241198	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:32241198G>A	uc003als.2	+	30	3111	c.2969G>A	c.(2968-2970)CGG>CAG	p.R990Q	DEPDC5_uc011als.1_Missense_Mutation_p.R921Q|DEPDC5_uc011alu.1_Missense_Mutation_p.R999Q|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.R990Q|DEPDC5_uc003alu.2_Missense_Mutation_p.R439Q|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.R320Q|DEPDC5_uc003alw.2_Missense_Mutation_p.R288Q|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_5'UTR	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	990					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ATTCGCAGGCGGCATCGCTCG	0.607		NaN											0	0	0	0.520397	0	16	19									
EP300	2033	broad.mit.edu	37	22	41564853	41564853	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:41564853G>A	uc003azl.3	+	25	4549	c.4154G>A	c.(4153-4155)TGC>TAC	p.C1385Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1385					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.C1385F(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGCTCTGACTGCCCTCCACCC	0.473		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.706142	0	23	143									
XRCC6	2547	broad.mit.edu	37	22	42042976	42042976	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:42042976C>T	uc003bao.1	+	7	920	c.850C>T	c.(850-852)CCT>TCT	p.P284S	XRCC6_uc003bap.1_Missense_Mutation_p.P243S|XRCC6_uc011apc.1_Missense_Mutation_p.P234S|XRCC6_uc003baq.1_Missense_Mutation_p.P284S|XRCC6_uc003bar.1_Missense_Mutation_p.P284S|XRCC6_uc003bas.1_Missense_Mutation_p.P234S	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	284	Ku.				DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						TCTCAAGCCTCCTCCAATAAA	0.433		NaN						Direct_reversal_of_damage|NHEJ					0	0	0	0.750413	0	25	217									
FBLN1	2192	broad.mit.edu	37	22	45927195	45927195	+	Missense_Mutation	SNP	C	C	A	rs147266682		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:45927195C>A	uc003bgj.1	+	5	682	c.535C>A	c.(535-537)CGC>AGC	p.R179S	FBLN1_uc003bgg.1_Missense_Mutation_p.R179S|FBLN1_uc003bgh.2_Missense_Mutation_p.R179S|FBLN1_uc010gzz.2_Missense_Mutation_p.R217S|FBLN1_uc003bgi.1_Missense_Mutation_p.R179S	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	179	EGF-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCTGAATGACCGCTGCCGAGG	0.398		NaN											1	0	9.80977e-26	0.796494	1.04837e-25	29	43									
GRM7	2917	broad.mit.edu	37	3	7456742	7456742	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:7456742G>A	uc003bqm.2	+	5	1340	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.E356K|GRM7_uc003bql.2_Missense_Mutation_p.E356K|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	356	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CCGTACACTTGAAAACAACAG	0.403		NaN											0	0	0	0.435327	0	12	31									
CELSR3	1951	broad.mit.edu	37	3	48699002	48699002	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:48699002C>G	uc003cul.2	-	1	1347	c.1066G>C	c.(1066-1068)GAG>CAG	p.E356Q	CELSR3_uc003cuf.1_Missense_Mutation_p.E426Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	356	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGCCCGGCCTCGCCGGCGTCC	0.672		NaN											0	0	0	0.457914	0	12	51									
SEMA5B	54437	broad.mit.edu	37	3	122634684	122634684	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:122634684C>T	uc003efz.1	-	13	2046	c.1742G>A	c.(1741-1743)CGT>CAT	p.R581H	SEMA5B_uc011bju.1_Missense_Mutation_p.R523H|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.R581H|SEMA5B_uc010hro.1_Missense_Mutation_p.R523H	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	581	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGTGCTGCAACGTTGCTGCTT	0.622		NaN											0	0	0	0.788014	0	32	44									
MRPL3	11222	broad.mit.edu	37	3	131220433	131220433	+	Silent	SNP	T	T	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:131220433T>C	uc003eoh.2	-	2	383	c.219A>G	c.(217-219)TTA>TTG	p.L73L	MRPL3_uc011blo.1_5'UTR|MRPL3_uc011blp.1_Silent_p.L100L	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	73					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						GTTTACTTGCTAATTGGGCTT	0.398		NaN											0	0	0	0.870114	0	96	184									
WDR49	151790	broad.mit.edu	37	3	167254660	167254660	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:167254660G>A	uc003fev.1	-	7	1202	c.896C>T	c.(895-897)ACG>ATG	p.T299M	WDR49_uc003feu.1_Missense_Mutation_p.T124M|WDR49_uc011bpd.1_Missense_Mutation_p.T363M|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	299	WD 5.									large_intestine(1)|ovary(1)|skin(1)	3						CAATTTACCCGTAACAAGAGT	0.373		NaN											0	0	0	0.520397	0	14	26									
PDGFRA	5156	broad.mit.edu	37	4	54248502	54248502	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:54248502G>A	uc003haa.2	+	4	414	c.228G>A	c.(226-228)CCG>CCA	p.P76P	FIP1L1_uc003gzx.3_Silent_p.P61P|FIP1L1_uc011bzt.1_Silent_p.P76P|FIP1L1_uc003gzy.2_Silent_p.P76P|FIP1L1_uc011bzu.1_Silent_p.P61P|FIP1L1_uc003gzz.2_Silent_p.P61P|FIP1L1_uc003hab.2_Silent_p.P64P|FIP1L1_uc003hac.2_5'UTR	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TACCAAAACCGGTAACATAAG	0.348		NaN	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.361761	0	9	69									
PDGFRA	5156	broad.mit.edu	37	4	54257217	54257217	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:54257217G>C	uc003haa.2	+	8	733	c.547G>C	c.(547-549)GAT>CAT	p.D183H	FIP1L1_uc003gzx.3_Missense_Mutation_p.D168H|FIP1L1_uc011bzt.1_Missense_Mutation_p.D183H|FIP1L1_uc003gzy.2_Missense_Mutation_p.D183H|FIP1L1_uc011bzu.1_Missense_Mutation_p.D168H|FIP1L1_uc003gzz.2_Missense_Mutation_p.D168H|FIP1L1_uc003hab.2_Missense_Mutation_p.D171H|FIP1L1_uc003hac.2_5'UTR	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:Variant_position_missing_in_P16234_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTTTAATGAAGATACCTGGAA	0.303		NaN	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.184627	0	4	58									
CXCL11	6373	broad.mit.edu	37	4	76956259	76956259	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:76956259C>G	uc003hjm.2	-	3	295	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_005409	NP_005400	O14625	CXL11_HUMAN	small inducible cytokine B11 precursor	68					cell-cell signaling|chemotaxis|inflammatory response|signal transduction	extracellular space	chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCTTTATTTTCTTTCAGGGTA	0.333		NaN											0	0	0	0.435327	0	11	73									
LRBA	987	broad.mit.edu	37	4	151357947	151357947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:151357947G>A	uc010ipj.2	-	46	7357	c.6883C>T	c.(6883-6885)CAA>TAA	p.Q2295*	LRBA_uc010ipi.2_5'UTR|LRBA_uc003ils.3_Nonsense_Mutation_p.Q185*|LRBA_uc003ilt.3_Nonsense_Mutation_p.Q943*|LRBA_uc003ilu.3_Nonsense_Mutation_p.Q2284*	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2295	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTTGGAACTTGATCATCTTCC	0.393		NaN											0	0	0	0.435327	0	11	38									
SLC9A3	6550	broad.mit.edu	37	5	485324	485324	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:485324G>A	uc003jbe.2	-	4	810	c.698C>T	c.(697-699)TCT>TTT	p.S233F	SLC9A3_uc011clx.1_Missense_Mutation_p.S233F	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	233	Extracellular (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGCCACGAAAGATTCAAACAC	0.632		NaN											0	0	0	0.740014	0	26	74									
SRD5A1	6715	broad.mit.edu	37	5	6656219	6656219	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:6656219G>T	uc003jdw.2	+	3	679	c.489G>T	c.(487-489)TTG>TTT	p.L163F	SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.L116F	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	163	Helical; (Potential).				androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	CGGGCATGTTGATAAACATCC	0.388		NaN											1	0	1.10513e-12	0.624587	1.15462e-12	16	30									
CTNND2	1501	broad.mit.edu	37	5	10981933	10981933	+	Silent	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:10981933C>T	uc003jfa.1	-	21	3514	c.3369G>A	c.(3367-3369)TTG>TTA	p.L1123L	CTNND2_uc010itt.2_Silent_p.L1032L|CTNND2_uc011cmy.1_Silent_p.L786L|CTNND2_uc011cmz.1_Silent_p.L690L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.L715L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1123					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AATTCCTATACAAAGTTGAAA	0.343		NaN											0	0	0	0.435327	0	10	125									
ERBB2IP	55914	broad.mit.edu	37	5	65310528	65310528	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:65310528G>A	uc003juk.1	+	7	816	c.508G>A	c.(508-510)GAA>AAA	p.E170K	ERBB2IP_uc003juh.1_Missense_Mutation_p.E170K|ERBB2IP_uc003jui.1_Missense_Mutation_p.E170K|ERBB2IP_uc003juj.1_Missense_Mutation_p.E170K|ERBB2IP_uc011cqx.1_Missense_Mutation_p.E170K|ERBB2IP_uc011cqy.1_Missense_Mutation_p.E170K|ERBB2IP_uc011cqz.1_Missense_Mutation_p.E170K|ERBB2IP_uc010iwx.1_Missense_Mutation_p.E170K|ERBB2IP_uc003jul.1_Missense_Mutation_p.E170K	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	170	LRR 7.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGAGCTTAGAGAAAACCAGTT	0.184		NaN											0	0	0	0.307466	0	7	24									
DMXL1	1657	broad.mit.edu	37	5	118485340	118485340	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:118485340C>T	uc003ksd.2	+	18	3999	c.3818C>T	c.(3817-3819)TCT>TTT	p.S1273F	DMXL1_uc010jcl.1_Missense_Mutation_p.S1273F	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1273										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AACTCCAGTTCTGGGTTACAT	0.403		NaN											0	0	0	0.27861	0	7	69									
PCDHA7	56141	broad.mit.edu	37	5	140214244	140214244	+	Silent	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:140214244C>G	uc003lhq.2	+	1	276	c.276C>G	c.(274-276)CGC>CGG	p.R92R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R92R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCGACCGCGAGGAGCTGT	0.587		NaN											0	0	0	0.870114	0	83	570									
PCDHA9	9752	broad.mit.edu	37	5	140228356	140228356	+	Silent	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:140228356C>G	uc003lhu.2	+	1	1000	c.276C>G	c.(274-276)CGC>CGG	p.R92R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.R92R	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCGACCGCGAGGAGCTGT	0.587		NaN											0	0	0	0.870114	0	46	19									
PCDHB11	56125	broad.mit.edu	37	5	140580672	140580672	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:140580672C>G	uc003liy.2	+	1	1325	c.1325C>G	c.(1324-1326)TCT>TGT	p.S442C	PCDHB11_uc011daj.1_Missense_Mutation_p.S77C	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	442	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGTTGGTCTCTGACGTCAAT	0.572		NaN											0	0	0	0.870114	0	40	228									
THG1L	54974	broad.mit.edu	37	5	157159883	157159883	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:157159883G>A	uc003lxd.2	+	2	325	c.199G>A	c.(199-201)GAG>AAG	p.E67K	THG1L_uc011ddu.1_5'UTR	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45	67					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAGGTTTGCTGAGAAGCACAA	0.473		NaN											0	0	0	0.27861	0	6	81									
HIST1H2BD	3017	broad.mit.edu	37	6	26158562	26158562	+	Missense_Mutation	SNP	C	C	G	rs141600148	byFrequency	TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:26158562C>G	uc003ngr.2	+	1	214	c.165C>G	c.(163-165)ATC>ATG	p.I55M	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.I55M	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	55					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						ACACCGGCATCTCTTCCAAGG	0.562		NaN											0	0	0	0.729181	0	30	245									
MDC1	9656	broad.mit.edu	37	6	30672587	30672587	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:30672587G>C	uc003nrg.3	-	10	4813	c.4373C>G	c.(4372-4374)TCC>TGC	p.S1458C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S1065C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1458	Pro-rich.|Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TGTGGAGGTGGAAGGCTGGAG	0.567		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.870114	0	41	149									
IP6K3	117283	broad.mit.edu	37	6	33694647	33694647	+	Silent	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:33694647G>C	uc010jvf.2	-	5	986	c.450C>G	c.(448-450)CTC>CTG	p.L150L	IP6K3_uc003ofb.2_Silent_p.L150L	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	150					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						CTGGAGTGTTGAGGTGGGGCT	0.647		NaN											0	0	0	0.307466	0	6	129									
DAAM2	23500	broad.mit.edu	37	6	39869784	39869784	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:39869784G>A	uc003oow.2	+	25	3334	c.3178G>A	c.(3178-3180)GAG>AAG	p.E1060K	DAAM2_uc003oox.2_Missense_Mutation_p.E1059K	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	1060					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGTTACCCGGGAGCGGGCAAT	0.612		NaN											0	0	0	0.435327	0	12	32									
ABCC10	89845	broad.mit.edu	37	6	43400565	43400565	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:43400565C>T	uc003ouy.1	+	3	1062	c.847C>T	c.(847-849)CGG>TGG	p.R283W	ABCC10_uc003ouz.1_Missense_Mutation_p.R240W|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	283						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCTTTGGACGGTGCTATCT	0.627		NaN											0	0	0	0.184627	0	4	50									
PLA2G7	7941	broad.mit.edu	37	6	46684211	46684211	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:46684211G>T	uc010jzf.2	-	4	555	c.286C>A	c.(286-288)CTT>ATT	p.L96I	PLA2G7_uc010jzg.1_Missense_Mutation_p.L96I|PLA2G7_uc011dwd.1_Missense_Mutation_p.L51I|PLA2G7_uc011dwe.1_Intron	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	96					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			GGGATCCAAAGGGTGTCAAGG	0.373		NaN											1	0	2.74318e-10	0.335167	2.84478e-10	7	73									
C6orf211	79624	broad.mit.edu	37	6	151779478	151779478	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:151779478G>A	uc003qok.1	+	3	422	c.163G>A	c.(163-165)GAA>AAA	p.E55K	C6orf211_uc011ees.1_5'UTR	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	55							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		CGTGGAAGCTGAAAAGAAAGC	0.348		NaN											0	0	0	0.575678	0	16	155									
WTAP	9589	broad.mit.edu	37	6	160174530	160174530	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:160174530T>C	uc003qsl.2	+	7	713	c.491T>C	c.(490-492)CTT>CCT	p.L164P	WTAP_uc003qso.2_Missense_Mutation_p.L45P	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	164					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TGTCGAATGCTTATCCAGGAG	0.438		NaN											0	0	0	0.639603	0	23	45									
EVX1	2128	broad.mit.edu	37	7	27285709	27285709	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:27285709G>A	uc003szd.1	+	3	1375	c.889G>A	c.(889-891)GCC>ACC	p.A297T	EVX1_uc011jzn.1_Missense_Mutation_p.A115T|EVX1_uc010kuy.1_3'UTR	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	297	Ala-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						CTCCGCCGCCGCCTCGCCCTT	0.776		NaN											0	0	0	0.184627	0	4	15									
CASD1	64921	broad.mit.edu	37	7	94163033	94163033	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:94163033C>T	uc003uni.3	+	7	774	c.547C>T	c.(547-549)CAA>TAA	p.Q183*	CASD1_uc003unh.2_Nonsense_Mutation_p.Q183*|CASD1_uc003unj.3_Nonsense_Mutation_p.Q183*	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	183						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AGCGCTTTCTCAATATAAAAT	0.318		NaN											0	0	0	0.520397	0	14	55									
RELN	5649	broad.mit.edu	37	7	103185777	103185777	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:103185777C>G	uc003vca.2	-	42	6477	c.6317G>C	c.(6316-6318)AGA>ACA	p.R2106T	RELN_uc010liz.2_Missense_Mutation_p.R2106T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2106					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGGTACCATCTGAAACGGAC	0.453		NaN											0	0	0	0.479597	0	12	42									
ZNF786	136051	broad.mit.edu	37	7	148768420	148768420	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:148768420G>A	uc003wfh.2	-	4	1581	c.1444C>T	c.(1444-1446)CAG>TAG	p.Q482*	ZNF786_uc011kuk.1_Nonsense_Mutation_p.Q445*|ZNF786_uc003wfi.2_Nonsense_Mutation_p.Q396*	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	482	C2H2-type 7; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTGGGCACTGAAAGGGCTTC	0.652		NaN											0	0	0	0.150653	0	3	21									
SLC7A2	6542	broad.mit.edu	37	8	17422584	17422584	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr8:17422584C>T	uc011kyc.1	+	12	2075	c.1906C>T	c.(1906-1908)CAA>TAA	p.Q636*	SLC7A2_uc011kyd.1_Nonsense_Mutation_p.Q675*|SLC7A2_uc011kye.1_Nonsense_Mutation_p.Q676*|SLC7A2_uc011kyf.1_Nonsense_Mutation_p.Q636*	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	636	Cytoplasmic (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATCTGCCATTCAAGCAAATGA	0.428		NaN											0	0	0	0.307466	0	7	28									
TRIM35	23087	broad.mit.edu	37	8	27145409	27145409	+	Silent	SNP	G	G	A	rs143436239		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr8:27145409G>A	uc003xfl.1	-	6	1222	c.1140C>T	c.(1138-1140)GGC>GGT	p.G380G	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	380	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		GGCCCTCAGCGCCCGAGTCCT	0.692		NaN											0	0	0	0.500413	0	14	27									
KCNU1	157855	broad.mit.edu	37	8	36766906	36766906	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr8:36766906G>A	uc010lvw.2	+	21	2271	c.2184G>A	c.(2182-2184)CCG>CCA	p.P728P	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	728	Segment S9.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCAGCCCCGATGGGGCTTC	0.468		NaN											0	0	0	0.435327	0	12	286									
TOPORS	10210	broad.mit.edu	37	9	32543241	32543241	+	Missense_Mutation	SNP	A	A	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr9:32543241A>C	uc003zrb.2	-	3	1449	c.1282T>G	c.(1282-1284)TCA>GCA	p.S428A	TOPORS_uc003zrc.2_Missense_Mutation_p.S361A	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	428					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ACCTGCTCTGAGCTTGAGTAA	0.453		NaN											0	0	0	0.870114	0	77	27									
COL27A1	85301	broad.mit.edu	37	9	117002529	117002529	+	Silent	SNP	C	C	T			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr9:117002529C>T	uc011lxl.1	+	20	2757	c.2757C>T	c.(2755-2757)GGC>GGT	p.G919G	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	919	Collagen-like 5.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCCCCCCTGGCGACAATGGCC	0.502		NaN											0	0	0	0.870114	0	65	24									
FANCB	2187	broad.mit.edu	37	X	14882865	14882865	+	Silent	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:14882865G>A	uc004cwg.1	-	3	1036	c.768C>T	c.(766-768)CTC>CTT	p.L256L	FANCB_uc004cwh.1_Silent_p.L256L	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	256					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TAAGGGCAATGAGAGATATTC	0.373		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.150653	0	4	50									
NXF3	56000	broad.mit.edu	37	X	102334549	102334549	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:102334549G>C	uc004eju.2	-	14	1253	c.1182C>G	c.(1180-1182)TTC>TTG	p.F394L	NXF3_uc010noi.1_Missense_Mutation_p.F244L	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	394	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TGCTATCCTTGAAGAACTTGC	0.507		NaN											0	0	0	0.624587	0	17	89									
GUCY2F	2986	broad.mit.edu	37	X	108628509	108628509	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:108628509G>A	uc004eod.3	-	16	3235	c.2959C>T	c.(2959-2961)CCG>TCG	p.P987S	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	987	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						GCAACAACCGGCCCTATAGAG	0.473		NaN											0	0	0	0.870114	0	51	18									
RPL10	6134	broad.mit.edu	37	X	153627864	153627864	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:153627864A>G	uc004fkm.2	+	4	307	c.119A>G	c.(118-120)AAG>AGG	p.K40R	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Missense_Mutation_p.K40R|RPL10_uc004fkn.1_Missense_Mutation_p.K40R|RPL10_uc004fkp.1_Missense_Mutation_p.K40R|RPL10_uc004fkq.1_RNA|RPL10_uc004fkr.1_5'Flank|SNORA70_uc010nux.1_5'Flank	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	40					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCGGAAAAAGGCAAAAGTG	0.522		NaN									OREG0019957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.217242	0	3	116									
ARID1A	8289	broad.mit.edu	37	1	27057936	27057937	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:27057936_27057937insC	uc001bmv.1	+	3	2017_2018	c.1644_1645insC	c.(1642-1647)CAGCCCfs	p.Q548fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.Q548fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.Q548fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.Q165fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	548_549					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Y551fs*72(1)|p.Q548*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCAGAGCCAGCCCCCCTACTC	0.649		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								NaN	NaN	NaN	NaN	NaN	155	276	---	---							
RUFY2	55680	broad.mit.edu	37	10	70166569	70166570	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:70166569_70166570insA	uc001job.2	-	1	377_378	c.50_51insT	c.(49-51)TTGfs	p.L17fs	RUFY2_uc001jnz.1_Intron|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Intron|RUFY2_uc001jod.1_Intron|RUFY2_uc009xpv.1_Intron|RUFY2_uc001joe.1_Intron	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	Error:Variant_position_missing_in_Q8WXA3_after_alignment						nucleus	metal ion binding			ovary(1)	1						GCACCCAGGCCAAAACCTGAGA	0.708		NaN											NaN	NaN	NaN	NaN	NaN	31	54	---	---							
CCAR1	55749	broad.mit.edu	37	10	70531073	70531074	+	Frame_Shift_Ins	INS	-	-	A	rs3205757		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:70531073_70531074insA	uc001joo.2	+	18	2528_2529	c.2409_2410insA	c.(2407-2412)GATAAAfs	p.D803fs	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Frame_Shift_Ins_p.D608fs|CCAR1_uc009xpx.1_Frame_Shift_Ins_p.D777fs|CCAR1_uc001jon.1_Frame_Shift_Ins_p.D749fs|CCAR1_uc010qiz.1_Frame_Shift_Ins_p.D788fs|CCAR1_uc010qja.1_Frame_Shift_Ins_p.D788fs|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	803_804	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						aagaaaaggataaaaaaagcaa	0.134		NaN											NaN	NaN	NaN	NaN	NaN	9	26	---	---							
TAOK2	9344	broad.mit.edu	37	16	29998498	29998500	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr16:29998498_29998500delCTG	uc002dva.1	+	16	3688_3690	c.2905_2907delCTG	c.(2905-2907)CTGdel	p.L974del	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_In_Frame_Del_p.L981del|TAOK2_uc002dvd.1_In_Frame_Del_p.L801del	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	974	Leu-rich.|Helical; (Potential).				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCTGCCCCTCCTGCTGCTGCTGC	0.709		NaN											NaN	NaN	NaN	NaN	NaN	7	110	---	---							
KCNG2	26251	broad.mit.edu	37	18	77623691	77623692	+	In_Frame_Ins	INS	-	-	GGC	rs71338073		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr18:77623691_77623692insGGC	uc010xfl.1	+	1	24_25	c.24_25insGGC	c.(22-27)insGGC	p.13_14insG		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	13_14	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCTccccgggcggcggcgg	0.614		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
DPPA4	55211	broad.mit.edu	37	3	109049606	109049606	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:109049606delT	uc003dxq.3	-	5	499	c.444delA	c.(442-444)AAAfs	p.K148fs	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Frame_Shift_Del_p.K148fs	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	148						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCACCTTTAATTTTTTTTGCA	0.413		NaN											NaN	NaN	NaN	NaN	NaN	7	163	---	---							
RREB1	6239	broad.mit.edu	37	6	7229719	7229725	+	Frame_Shift_Del	DEL	TCGGCCA	TCGGCCA	-	rs147038452		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:7229719_7229725delTCGGCCA	uc003mxc.2	+	10	1777_1783	c.1387_1393delTCGGCCA	c.(1387-1395)TCGGCCATCfs	p.S463fs	RREB1_uc003mxb.2_Frame_Shift_Del_p.S463fs|RREB1_uc010jnx.2_Frame_Shift_Del_p.S463fs	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	463_465					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTCTGGCGAGTCGGCCATCGAGCTGGC	0.599		NaN											NaN	NaN	NaN	NaN	NaN	103	50	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36652057	36652058	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:36652057_36652058insG	uc003omm.3	+	2	301_302	c.179_180insG	c.(178-180)GAGfs	p.E60fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E94fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E60fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E60fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	60					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						ACACCACTGGAGGGTGACTTCG	0.668		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	34	29	---	---							
NCR2	9436	broad.mit.edu	37	6	41303645	41303647	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:41303645_41303647delCTG	uc003oqh.2	+	1	118_120	c.31_33delCTG	c.(31-33)CTGdel	p.L15del	NCR2_uc003oqi.2_In_Frame_Del_p.L15del|NCR2_uc003oqj.2_In_Frame_Del_p.L15del	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	15					cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCACTGCTACTGCTGCTGCTGC	0.635		NaN											NaN	NaN	NaN	NaN	NaN	4	5	---	---