Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
NADK	65220	broad.mit.edu	37	1	1685647	1685647	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:1685647C>T	uc009vkw.2	-	10	1065	c.944G>A	c.(943-945)GGA>GAA	p.G315E	NADK_uc001aic.2_Missense_Mutation_p.G315E|NADK_uc001aid.3_Missense_Mutation_p.G315E|NADK_uc001aie.2_Missense_Mutation_p.G460E|NADK_uc010nyv.1_Missense_Mutation_p.G283E|NADK_uc009vkx.1_3'UTR	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	315					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CACGATCACTCCTGACAGGGA	0.701		NaN											0	0	0	0.027356	0	25	37									
NPHP4	261734	broad.mit.edu	37	1	5926434	5926434	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:5926434A>G	uc001alq.1	-	26	3909	c.3643T>C	c.(3643-3645)TCG>CCG	p.S1215P	NPHP4_uc001alr.1_Missense_Mutation_p.S157P	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	1215					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGCACTTACGAGTAAATGATG	0.597		NaN											0	0	0	0.014758	0	4	21									
USP48	84196	broad.mit.edu	37	1	22033020	22033020	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:22033020C>G	uc001bfb.2	-	17	2389	c.2151G>C	c.(2149-2151)AAG>AAC	p.K717N	USP48_uc001bfa.2_Missense_Mutation_p.K255N|USP48_uc010odq.1_Missense_Mutation_p.K729N|USP48_uc009vqc.2_Missense_Mutation_p.K651N|USP48_uc001bfc.2_Missense_Mutation_p.K717N|USP48_uc001bfd.1_5'Flank	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	717	DUSP 3.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GGAGAGAAGTCTTTTGCTCGT	0.388		NaN											0	0	0	0.01441	0	71	143									
HSPG2	3339	broad.mit.edu	37	1	22191497	22191497	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:22191497C>G	uc001bfj.2	-	36	4505	c.4465G>C	c.(4465-4467)GAT>CAT	p.D1489H	HSPG2_uc009vqd.2_Missense_Mutation_p.D1490H	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1489	Laminin IV type A 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGGAGCTCATCCAGGTCGGCC	0.711		NaN											0	0	0	0.014758	0	4	4									
EPHB2	2048	broad.mit.edu	37	1	23111208	23111208	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:23111208G>A	uc009vqj.1	+	3	595	c.450G>A	c.(448-450)GTG>GTA	p.V150V	EPHB2_uc001bge.2_Silent_p.V150V|EPHB2_uc001bgf.2_Silent_p.V150V|EPHB2_uc010odu.1_Silent_p.V150V	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	150	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TCTCCCAGGTGGACCTGGGTG	0.597		NaN							Hereditary_Prostate_Cancer				0	0	0	0.001984	0	6	47									
KDM1A	23028	broad.mit.edu	37	1	23380296	23380296	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:23380296G>A	uc001bgi.2	+	4	843	c.694G>A	c.(694-696)GAG>AAG	p.E232K	KDM1A_uc001bgj.2_Missense_Mutation_p.E252K	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	232	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						GCTGACATTTGAGGCTACTCT	0.333		NaN											0	0	0	0.024245	0	13	62									
RCAN3	11123	broad.mit.edu	37	1	24857725	24857725	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:24857725C>G	uc001bjj.2	+	3	526	c.213C>G	c.(211-213)CTC>CTG	p.L71L	RCAN3_uc009vrd.2_Silent_p.L71L|RCAN3_uc009vre.2_Intron|RCAN3_uc009vrf.2_Silent_p.L71L|RCAN3_uc009vrg.2_Intron	NM_013441	NP_038469	Q9UKA8	RCAN3_HUMAN	Down syndrome critical region gene 1-like 2	71					anatomical structure morphogenesis|calcium-mediated signaling		nucleotide binding|RNA binding|troponin I binding				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00473)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0427)|OV - Ovarian serous cystadenocarcinoma(117;1.13e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;0.000923)|BRCA - Breast invasive adenocarcinoma(304;0.0018)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.00493)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.14)		TTGAAGCACTCTTCACCATCT	0.388		NaN											0	0	0	0.024245	0	14	171									
RHCE	6006	broad.mit.edu	37	1	25729100	25729100	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:25729100C>T	uc001bkf.2	-	3	559	c.473G>A	c.(472-474)AGT>AAT	p.S158N	RHCE_uc001bkg.2_Missense_Mutation_p.S158N|RHCE_uc001bkh.2_Missense_Mutation_p.S158N|RHCE_uc001bki.2_Missense_Mutation_p.S158N|RHCE_uc001bkj.2_Missense_Mutation_p.S142N	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	158						integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGATATTACTGATGACCAT	0.532		NaN											0	0	0	0.021022	0	35	178									
MAN1C1	57134	broad.mit.edu	37	1	26073233	26073233	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:26073233G>T	uc001bkm.2	+	3	1042	c.712G>T	c.(712-714)GAG>TAG	p.E238*	MAN1C1_uc009vry.1_Nonsense_Mutation_p.E58*	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	238	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GGAGTTCCAGGAGGCCAAGGC	0.642		NaN											1	0	2.44723e-14	0.024334	2.63928e-14	23	35									
ZBTB8A	653121	broad.mit.edu	37	1	33058581	33058581	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:33058581C>T	uc001bvn.2	+	3	534	c.49C>T	c.(49-51)CAG>TAG	p.Q17*	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Nonsense_Mutation_p.Q17*	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGAACGAGCAGCGCAGGCA	0.418		NaN											0	0	0	0.021523	0	25	36									
YARS	8565	broad.mit.edu	37	1	33272134	33272134	+	Silent	SNP	T	T	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:33272134T>A	uc001bvy.1	-	4	1247	c.459A>T	c.(457-459)GTA>GTT	p.V153V		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	153			Missing (in CMTDIC).		apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	CCACCTGCTTTACCACCTCAG	0.542		NaN											0	0	0	0.009535	0	29	141									
NT5C1A	84618	broad.mit.edu	37	1	40131908	40131908	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:40131908G>A	uc001cdq.1	-	2	136	c.136C>T	c.(136-138)CCC>TCC	p.P46S		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	46					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TGAGGCTTGGGCTGCAGAGGT	0.582		NaN											0	0	0	0.014758	0	5	93									
STIL	6491	broad.mit.edu	37	1	47716863	47716863	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:47716863G>A	uc001crc.1	-	17	3964	c.3809C>T	c.(3808-3810)TCA>TTA	p.S1270L	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.S1224L|STIL_uc010omo.1_Missense_Mutation_p.S1253L|STIL_uc001crd.1_Missense_Mutation_p.S1271L|STIL_uc001cre.1_Missense_Mutation_p.S1270L	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1270					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GGTGCCTACTGAATTCATGCT	0.383		NaN											0	0	0	0.01441	0	82	70									
ZNHIT6	54680	broad.mit.edu	37	1	86172186	86172186	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:86172186C>G	uc001dlh.2	-	2	795	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	ZNHIT6_uc010osc.1_Missense_Mutation_p.E182Q	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	221	HIT-type.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						CCACAAGTCTCACACCTACAA	0.318		NaN											0	0	0	0.01441	0	64	115									
BRDT	676	broad.mit.edu	37	1	92441909	92441909	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:92441909C>A	uc001dok.3	+	5	881	c.532C>A	c.(532-534)CCT>ACT	p.P178T	BRDT_uc001dol.3_Missense_Mutation_p.P178T|BRDT_uc010osz.1_Missense_Mutation_p.P182T|BRDT_uc009wdf.2_Missense_Mutation_p.P105T|BRDT_uc010ota.1_Missense_Mutation_p.P132T|BRDT_uc010otb.1_Missense_Mutation_p.P132T|BRDT_uc001dom.3_Missense_Mutation_p.P178T	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GCAAGAAATTCCTTCTGTATT	0.403		NaN											1	0	4.36969e-10	0.016723	4.60926e-10	12	83									
BCAR3	8412	broad.mit.edu	37	1	94027918	94027918	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:94027918C>G	uc001dpz.2	-	12	2633	c.2358G>C	c.(2356-2358)TTG>TTC	p.L786F	BCAR3_uc001dqa.2_Missense_Mutation_p.L786F|BCAR3_uc001dqb.2_Missense_Mutation_p.L786F|BCAR3_uc001dpx.3_Missense_Mutation_p.L462F|BCAR3_uc001dpy.2_Missense_Mutation_p.L695F	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	786	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TGCCCCATAGCAATCGCATTT	0.388		NaN											0	0	0	0.01441	0	74	72									
CSF1	1435	broad.mit.edu	37	1	110456967	110456967	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:110456967G>A	uc001dyu.2	+	2	539	c.126G>A	c.(124-126)ATG>ATA	p.M42I	CSF1_uc001dyt.2_Missense_Mutation_p.M42I|CSF1_uc001dyv.3_Missense_Mutation_p.M42I|CSF1_uc001dyw.3_Missense_Mutation_p.M42I	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	42	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GTAGCCACATGATTGGGAGTG	0.582		NaN											0	0	0	0.013537	0	13	54									
RAP1A	5906	broad.mit.edu	37	1	112246033	112246033	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:112246033C>A	uc001ebi.2	+	5	363	c.259C>A	c.(259-261)CAG>AAG	p.Q87K	RAP1A_uc001ebk.2_Missense_Mutation_p.Q87K|RAP1A_uc001ebl.2_Missense_Mutation_p.Q87K|RAP1A_uc001ebm.2_RNA	NM_002884	NP_002875	P62834	RAP1A_HUMAN	RAP1A, member of RAS oncogene family precursor	87					activation of MAPKK activity|blood coagulation|energy reserve metabolic process|nerve growth factor receptor signaling pathway|regulation of insulin secretion	cytosol|plasma membrane	GTP binding|GTPase activity				0		all_cancers(81;6.79e-06)|all_epithelial(167;2.42e-05)|all_lung(203;0.000105)|Lung NSC(277;0.00021)		Lung(183;0.0183)|Colorectal(144;0.0418)|LUSC - Lung squamous cell carcinoma(189;0.0966)|all cancers(265;0.098)|Epithelial(280;0.0981)|COAD - Colon adenocarcinoma(174;0.141)		TATTACAGCTCAGTCCACGTT	0.358		NaN											1	0	8.24728e-16	0.024334	8.95473e-16	23	93									
FCGR1B	2210	broad.mit.edu	37	1	120930097	120930097	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:120930097G>A	uc001eip.2	-	4	554	c.504C>T	c.(502-504)TGC>TGT	p.C168C	FCGR1B_uc001eiq.2_Silent_p.C76C|FCGR1B_uc010oxl.1_RNA|FCGR1B_uc009whr.2_Silent_p.C168C|FCGR1B_uc009whs.2_Silent_p.C169C	NM_001017986	NP_001017986	Q92637	FCGRB_HUMAN	Fc fragment of IgG, high affinity Ib, receptor	168	Extracellular (Potential).|Ig-like C2-type 2.				interferon-gamma-mediated signaling pathway	integral to membrane|plasma membrane	IgG binding|immunoglobulin receptor activity				0	all_neural(166;0.181)	all_lung(203;7.27e-05)|Lung NSC(69;0.000389)|all_epithelial(167;0.068)		Lung(183;0.0327)|LUSC - Lung squamous cell carcinoma(189;0.19)		CCATGCCTGAGCAATGGTAGG	0.408		NaN											0	0	0	0.01441	0	37	230									
HORMAD1	84072	broad.mit.edu	37	1	150676596	150676596	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:150676596G>A	uc001evk.1	-	12	1052	c.946C>T	c.(946-948)CAG>TAG	p.Q316*	HORMAD1_uc001evl.1_Nonsense_Mutation_p.Q309*|HORMAD1_uc001evm.1_Nonsense_Mutation_p.Q236*	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	316					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GTTTATACCTGAGAATGAGAA	0.299		NaN											0	0	0	0.021553	0	5	77									
IVL	3713	broad.mit.edu	37	1	152882824	152882824	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:152882824A>T	uc001fau.2	+	2	597	c.551A>T	c.(550-552)GAG>GTG	p.E184V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	184	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].|4.				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			gggcagctggagctcccagag	0.055		NaN											0	0	0	0.004672	0	3	7									
INTS3	65123	broad.mit.edu	37	1	153744827	153744827	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153744827C>G	uc009wom.2	+	28	2953	c.2732C>G	c.(2731-2733)TCT>TGT	p.S911C	INTS3_uc001fct.2_Missense_Mutation_p.S911C|INTS3_uc001fcu.2_Missense_Mutation_p.S603C|INTS3_uc001fcv.2_Missense_Mutation_p.S705C|INTS3_uc010peb.1_Missense_Mutation_p.S705C|INTS3_uc001fcw.2_Missense_Mutation_p.S424C|INTS3_uc010pec.1_Missense_Mutation_p.S424C|INTS3_uc001fcy.2_Missense_Mutation_p.S208C|INTS3_uc001fcx.2_Missense_Mutation_p.S208C	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	912					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGAGGAGCTCTAGCAGCAAG	0.592		NaN									OREG0013827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.020292	0	13	101									
DENND4B	9909	broad.mit.edu	37	1	153906649	153906649	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153906649C>T	uc001fdd.1	-	19	3304	c.2903G>A	c.(2902-2904)CGA>CAA	p.R968Q	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	968										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGTGCCCCTCGGGCACTGCC	0.642		NaN											0	0	0	0.009096	0	4	10									
DENND4B	9909	broad.mit.edu	37	1	153910053	153910053	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153910053C>G	uc001fdd.1	-	15	2544	c.2143G>C	c.(2143-2145)GAG>CAG	p.E715Q		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	715										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGAAGAGACTCAAACAACTCA	0.607		NaN											0	0	0	0.001984	0	7	32									
DENND4B	9909	broad.mit.edu	37	1	153910278	153910278	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153910278C>T	uc001fdd.1	-	14	2428	c.2027G>A	c.(2026-2028)GGA>GAA	p.G676E		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	676										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAGCTCACTTCCTGACAGCTC	0.542		NaN											0	0	0	0.027356	0	28	177									
MEX3A	92312	broad.mit.edu	37	1	156047421	156047421	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:156047421C>T	uc001fnd.3	-	2	507	c.507G>A	c.(505-507)CCG>CCA	p.P169P		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	169	KH 1.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					CGCCCCTCACCGGTGTCTTGA	0.587		NaN											0	0	0	0.008291	0	10	16									
IQGAP3	128239	broad.mit.edu	37	1	156521553	156521553	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:156521553G>A	uc001fpf.2	-	15	1753	c.1678C>T	c.(1678-1680)CCT>TCT	p.P560S	IQGAP3_uc009wsb.1_Missense_Mutation_p.P517S	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	560					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGCGACAGGGAGGCTGACA	0.572		NaN											0	0	0	0.027356	0	25	49									
BAT2L2	23215	broad.mit.edu	37	1	171506532	171506532	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:171506532G>A	uc010pmg.1	+	15	2684	c.2418G>A	c.(2416-2418)CTG>CTA	p.L806L	BAT2L2_uc010pmh.1_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	806							protein C-terminus binding				0						CTCGTATGCTGTGGGGGTCAG	0.458		NaN											0	0	0	0.014758	0	5	31									
PIGC	5279	broad.mit.edu	37	1	172410895	172410895	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:172410895C>T	uc001gil.2	-	2	1149	c.868G>A	c.(868-870)GAA>AAA	p.E290K	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Missense_Mutation_p.E290K|PIGC_uc001gio.2_Missense_Mutation_p.E290K	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	290					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						GACAAGTCTTCCTTGATTTCA	0.388		NaN											0	0	0	0.01441	0	49	543									
RABGAP1L	9910	broad.mit.edu	37	1	174247872	174247872	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:174247872C>G	uc001gjx.2	+	10	1473	c.1278C>G	c.(1276-1278)TTC>TTG	p.F426L	RABGAP1L_uc009wwq.1_Missense_Mutation_p.F438L|RABGAP1L_uc001gjw.2_Missense_Mutation_p.F389L|RABGAP1L_uc001gjy.2_Missense_Mutation_p.F94L|RABGAP1L_uc001gjz.2_Missense_Mutation_p.F73L	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	426					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						TTTGGTATTTCAGCAGAAAGA	0.423		NaN											0	0	0	0.01441	0	148	320									
FAM129A	116496	broad.mit.edu	37	1	184792404	184792404	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:184792404C>G	uc001gra.2	-	8	1076	c.882G>C	c.(880-882)TTG>TTC	p.L294F	FAM129A_uc001grb.1_Missense_Mutation_p.L57F|FAM129A_uc009wyh.1_Missense_Mutation_p.L122F|FAM129A_uc009wyi.1_Missense_Mutation_p.L92F	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	294					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						ATTCCTCCTTCAAGGCACTTA	0.458		NaN											0	0	0	0.020292	0	15	242									
ADORA1	134	broad.mit.edu	37	1	203134960	203134960	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:203134960G>A	uc001gze.1	+	4	1346	c.913G>A	c.(913-915)GAC>AAC	p.D305N	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.D305N|ADORA1_uc010pqg.1_Missense_Mutation_p.D237N|ADORA1_uc009xak.1_3'UTR|ADORA1_uc010pqh.1_Missense_Mutation_p.D338N	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	305	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GATTTGGAATGACCATTTCCG	0.572		NaN											0	0	0	0.004007	0	16	38									
PLXNA2	5362	broad.mit.edu	37	1	208227794	208227794	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:208227794G>C	uc001hgz.2	-	14	3586	c.2828C>G	c.(2827-2829)ACG>AGG	p.T943R		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	943	Extracellular (Potential).|IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ATGGGACTTCGTCATGAACTC	0.592		NaN											0	0	0	0.00499	0	18	55									
USH2A	7399	broad.mit.edu	37	1	216348659	216348659	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:216348659C>T	uc001hku.1	-	21	4949	c.4562G>A	c.(4561-4563)CGT>CAT	p.R1521H	USH2A_uc001hkv.2_Missense_Mutation_p.R1521H	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1521	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCTATGAAACGGATTCCTTT	0.428		NaN								HNSCC(13;0.011)			0	0	0	0.00499	0	17	48									
HHIPL2	79802	broad.mit.edu	37	1	222696178	222696178	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:222696178G>A	uc001hnh.1	-	9	1998	c.1940C>T	c.(1939-1941)TCT>TTT	p.S647F		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	647					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		TGCACTGGAAGATTTTCTAGC	0.433		NaN											0	0	0	0.014323	0	22	150									
OBSCN	84033	broad.mit.edu	37	1	228464926	228464926	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:228464926C>T	uc009xez.1	+	24	6710	c.6666C>T	c.(6664-6666)CTC>CTT	p.L2222L	OBSCN_uc001hsn.2_Silent_p.L2222L|OBSCN_uc001hsp.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2222	Ig-like 22.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCAGGAGCCTCACCATTTACC	0.637		NaN											0	0	0	0.001984	0	6	7									
OR2C3	81472	broad.mit.edu	37	1	247694861	247694861	+	Missense_Mutation	SNP	G	G	A	rs147306837		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:247694861G>A	uc009xgy.2	-	2	1315	c.953C>T	c.(952-954)GCG>GTG	p.A318V	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	318	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CTAAATTTGCGCCAGCTTGCC	0.512		NaN											0	0	0	0.004007	0	16	42									
AKR1E2	83592	broad.mit.edu	37	10	4889679	4889679	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:4889679G>A	uc001ihi.2	+	10	1036	c.921_splice	c.e10-1	p.I307_splice	AKR1E2_uc001ihl.1_Intron|AKR1E2_uc009xhw.2_Splice_Site_p.I209_splice|AKR1E2_uc001ihj.2_Splice_Site|AKR1E2_uc001ihk.2_Splice_Site_p.I250_splice	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2							cytoplasm	1,5-anhydro-D-fructose reductase activity				0						CTGTTTTTCAGAACTAAAAAT	0.343		NaN											0	0	0	0.024245	0	14	106									
PFKFB3	5209	broad.mit.edu	37	10	6262698	6262698	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:6262698G>T	uc001ije.2	+	8	1085	c.701G>T	c.(700-702)CGC>CTC	p.R234L	PFKFB3_uc001ijd.2_Missense_Mutation_p.R214L|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Missense_Mutation_p.R248L|PFKFB3_uc001ijf.2_Missense_Mutation_p.R234L	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	234	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						ATCCAGAGCCGCATCGTGTAC	0.622		NaN											1	0	2.35188e-11	0.006122	2.49175e-11	16	115									
FAM171A1	221061	broad.mit.edu	37	10	15325988	15325988	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:15325988C>T	uc001iob.2	-	2	221	c.214G>A	c.(214-216)GGC>AGC	p.G72S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	72	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						AAGGCGACGCCATCAGTCCCC	0.577		NaN											0	0	0	0.027356	0	29	21									
ZNF33B	7582	broad.mit.edu	37	10	43088814	43088815	+	Missense_Mutation	DNP	AT	AT	TA	rs149558146	by1000genomes	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:43088814_43088815AT>TA	uc001jaf.1	-	5	1698_1699	c.1583_1584AT>TA	c.(1582-1584)TAT>TTA	p.Y528L	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.Y416L|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	528	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCCCACATTCATAACATTCATA	0.411		NaN											0	0	0	0.004672	0	49	104									
PPA1	5464	broad.mit.edu	37	10	71978536	71978536	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:71978536G>C	uc001jqv.1	-	3	268	c.161C>G	c.(160-162)TCT>TGT	p.S54C		NM_021129	NP_066952	Q15181	IPYR_HUMAN	pyrophosphatase 1	54					diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(1)	1						TTTTGCATTAGACCAGCGTGG	0.403		NaN											0	0	0	0.016723	0	12	16									
OIT3	170392	broad.mit.edu	37	10	74692170	74692170	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:74692170G>T	uc001jte.1	+	9	1744	c.1526G>T	c.(1525-1527)TGT>TTT	p.C509F	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	509	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					CGTTCCCGCTGTGCCCAGGGT	0.567		NaN											1	0	3.38236e-24	0.027894	3.73145e-24	38	93									
ZMIZ1	57178	broad.mit.edu	37	10	81050724	81050724	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:81050724G>A	uc001kaf.2	+	10	1121	c.549G>A	c.(547-549)GGG>GGA	p.G183G	ZMIZ1_uc001kag.2_Silent_p.G59G|ZMIZ1_uc001kah.1_Silent_p.G59G	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	183					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGGTCCTTGGGAACCCTATGG	0.567		NaN											0	0	0	0.020292	0	15	39									
RNLS	55328	broad.mit.edu	37	10	90342026	90342026	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:90342026G>T	uc001kfe.2	-	2	292	c.157C>A	c.(157-159)CAG>AAG	p.Q53K	RNLS_uc010qms.1_Intron|RNLS_uc001kfd.2_Missense_Mutation_p.Q53K	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	renalase isoform 1	53						extracellular region	oxidoreductase activity			ovary(1)	1						GCTGTGCACTGAGGATTATGA	0.433		NaN											1	0	2.80697e-09	0.010729	2.94794e-09	11	18									
NPM3	10360	broad.mit.edu	37	10	103542092	103542092	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:103542092A>C	uc001ktt.2	-	4	364	c.341T>G	c.(340-342)TTC>TGC	p.F114C		NM_006993	NP_008924	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	114							nucleic acid binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		TTGGAGCTGGAAGTCATCCAG	0.592		NaN											0	0	0	0.004672	0	3	10									
C10orf79	80217	broad.mit.edu	37	10	105942272	105942272	+	Splice_Site	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:105942272C>T	uc001kxw.2	-	17	2258	c.2142_splice	c.e17-1	p.K714_splice	C10orf79_uc009xxq.2_Splice_Site_p.K22_splice|C10orf79_uc001kxx.3_Splice_Site_p.K715_splice	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217												0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCCAAATCGCCTATATTAATA	0.323		NaN											0	0	0	0.008291	0	10	37									
RAB11FIP2	22841	broad.mit.edu	37	10	119799755	119799755	+	Silent	SNP	C	C	A	rs138355819		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:119799755C>A	uc001ldj.1	-	2	1115	c.675G>T	c.(673-675)GCG>GCT	p.A225A	RAB11FIP2_uc009xyz.1_Silent_p.A225A	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	225					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		ACATTGAATGCGCTGACGAGA	0.443		NaN											1	0	4.34086e-07	0.023175	4.50962e-07	36	134									
DMBT1	1755	broad.mit.edu	37	10	124339407	124339407	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:124339407C>T	uc001lgk.1	+	10	1099	c.993C>T	c.(991-993)GTC>GTT	p.V331V	DMBT1_uc001lgl.1_Silent_p.V331V|DMBT1_uc001lgm.1_Silent_p.V331V|DMBT1_uc009xzz.1_Silent_p.V331V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.V183V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	331	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ACGCTGGTGTCATCTGCTCAG	0.527		NaN											0	0	0	0.020292	0	14	60									
C10orf137	26098	broad.mit.edu	37	10	127414265	127414265	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:127414265G>T	uc001liq.1	+	6	943	c.650G>T	c.(649-651)GGA>GTA	p.G217V	C10orf137_uc001lin.2_Missense_Mutation_p.G217V|C10orf137_uc001lio.1_Missense_Mutation_p.G217V|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AATGGTGATGGAGCCGCTCAG	0.453		NaN											1	0	9.31168e-06	0.016723	9.61141e-06	12	38									
ANO9	338440	broad.mit.edu	37	11	433382	433382	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:433382G>A	uc001lpi.2	-	4	367	c.282C>T	c.(280-282)CTC>CTT	p.L94L	ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	94	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CAGGCTCCAGGAGGAAAGTGC	0.647		NaN											0	0	0	0.007413	0	19	75									
CTSD	1509	broad.mit.edu	37	11	1782618	1782618	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:1782618C>T	uc001luc.1	-	2	282	c.149G>A	c.(148-150)GGC>GAC	p.G50D	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	50					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAGACGGGGCCTTTGGCAAT	0.622		NaN											0	0	0	0.024245	0	15	43									
OSBPL5	114879	broad.mit.edu	37	11	3111839	3111839	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:3111839C>G	uc001lxk.2	-	20	2505	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q	OSBPL5_uc010qxq.1_Missense_Mutation_p.E694Q|OSBPL5_uc009ydw.2_Missense_Mutation_p.E715Q|OSBPL5_uc001lxl.2_Missense_Mutation_p.E715Q|OSBPL5_uc001lxj.2_Missense_Mutation_p.E237Q	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	783					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGGCAGGACTCAGGCGTGGAT	0.667		NaN											0	0	0	0.009096	0	4	34									
RRM1	6240	broad.mit.edu	37	11	4127384	4127384	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:4127384G>C	uc001lyw.3	+	3	536	c.217G>C	c.(217-219)GAC>CAC	p.D73H	RRM1_uc009yeh.1_Intron|RRM1_uc009yei.2_Missense_Mutation_p.D33H|RRM1_uc010qyc.1_Intron	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	73	ATP-cone.				deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TAAGCACCCTGACTATGCTAT	0.448		NaN											0	0	0	0.008871	0	18	41									
DNHD1	144132	broad.mit.edu	37	11	6588563	6588563	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:6588563C>G	uc001mdw.3	+	36	12388	c.11824C>G	c.(11824-11826)CTG>GTG	p.L3942V	DNHD1_uc001mea.3_Missense_Mutation_p.L211V|DNHD1_uc001meb.2_Missense_Mutation_p.L210V|DNHD1_uc001mec.2_Missense_Mutation_p.L210V|DNHD1_uc010rao.1_Missense_Mutation_p.L200V|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3942					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CGCTTTGGCTCTGCTGCAAGC	0.597		NaN											0	0	0	0.00499	0	17	47									
ABCC8	6833	broad.mit.edu	37	11	17464306	17464306	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:17464306T>A	uc001mnc.2	-	10	1717	c.1591A>T	c.(1591-1593)ACC>TCC	p.T531S	ABCC8_uc010rcy.1_Missense_Mutation_p.T530S	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	531	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGAGGCTGGTCATCTCCTTC	0.607		NaN											0	0	0	0.013537	0	13	65									
KIF18A	81930	broad.mit.edu	37	11	28057955	28057955	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:28057955G>A	uc001msc.2	-	14	2387	c.2205C>T	c.(2203-2205)ATC>ATT	p.I735I		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	735					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TGTTTGAGCTGATAGCCTGAA	0.353		NaN											0	0	0	0.01441	0	56	153									
EXT2	2132	broad.mit.edu	37	11	44129413	44129413	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:44129413G>T	uc001mxz.2	+	2	485	c.151G>T	c.(151-153)GAG>TAG	p.E51*	EXT2_uc010rfo.1_Nonsense_Mutation_p.E79*|EXT2_uc001mxy.2_Nonsense_Mutation_p.E64*|EXT2_uc009ykt.2_Nonsense_Mutation_p.E51*|EXT2_uc001mya.2_Nonsense_Mutation_p.E84*	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	51	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						CCATTCTATCGAGTCCTCAAA	0.532		NaN	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				1	0	3.07112e-06	0.010729	3.17679e-06	12	207									
MAPK8IP1	9479	broad.mit.edu	37	11	45924345	45924345	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:45924345G>C	uc001nbr.2	+	5	1197	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	343					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		GTCGTCCCCAGAGCGGGCTGA	0.721		NaN											0	0	0	0.009096	0	4	12									
ACP2	53	broad.mit.edu	37	11	47267305	47267305	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:47267305C>T	uc001nei.2	-	4	495	c.378G>A	c.(376-378)GGG>GGA	p.G126G	ACP2_uc010rhe.1_Silent_p.G98G|ACP2_uc009ylj.2_Silent_p.G54G|ACP2_uc010rhf.1_Silent_p.G94G|ACP2_uc010rhg.1_Silent_p.G126G|ACP2_uc010rhh.1_5'UTR|ACP2_uc010rhi.1_5'UTR|ACP2_uc009ylk.2_Silent_p.G126G|ACP2_uc010rhj.1_Silent_p.G126G|NR1H3_uc009yll.1_5'Flank|NR1H3_uc010rhk.1_5'Flank	NM_001610	NP_001601	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal isoform 1	126	Lumenal (Potential).					integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			ovary(1)	1						AGCGCTGCATCCCGTTGGGAG	0.572		NaN											0	0	0	0.007413	0	16	127									
OR4A5	81318	broad.mit.edu	37	11	51411989	51411989	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:51411989C>T	uc001nhi.1	-	1	407	c.407G>A	c.(406-408)CGA>CAA	p.R136Q		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GCAAACCTGTCGATTCATGAT	0.478		NaN											0	0	0	0.016723	0	13	89									
OR8H3	390152	broad.mit.edu	37	11	55889867	55889867	+	Missense_Mutation	SNP	G	G	A	rs148197076		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:55889867G>A	uc001nii.1	+	1	19	c.19G>A	c.(19-21)GAC>AAC	p.D7N		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TAGAAGGAATGACACAAATGT	0.323		NaN											0	0	0	0.01441	0	45	187									
OR4D9	390199	broad.mit.edu	37	11	59283252	59283252	+	Silent	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:59283252G>T	uc010rkv.1	+	1	867	c.867G>T	c.(865-867)CTG>CTT	p.L289L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTACACGCTGAGGAATCAGG	0.453		NaN											1	0	6.32553e-13	0.024334	6.7463e-13	27	188									
OR4D9	390199	broad.mit.edu	37	11	59283288	59283288	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:59283288G>A	uc010rkv.1	+	1	903	c.903G>A	c.(901-903)CTG>CTA	p.L301L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGAGGAAACTGAAGAGACGGC	0.388		NaN											0	0	0	0.010504	0	21	132									
VPS37C	55048	broad.mit.edu	37	11	60901556	60901556	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:60901556C>G	uc001nqv.1	-	3	277	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	VPS37C_uc001nqw.1_Missense_Mutation_p.E73Q	NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	73					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						TTCCGGAGCTCCTGGTATCTA	0.617		NaN											0	0	0	0.013114	0	43	120									
TRPT1	83707	broad.mit.edu	37	11	63991404	63991404	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:63991404C>G	uc001nyo.2	-	8	920	c.706G>C	c.(706-708)GAG>CAG	p.E236Q	TRPT1_uc010rnc.1_Missense_Mutation_p.E237Q|TRPT1_uc010rnd.1_Missense_Mutation_p.E238Q|TRPT1_uc001nyn.2_Missense_Mutation_p.E187Q|TRPT1_uc010rne.1_Missense_Mutation_p.E199Q|TRPT1_uc010rnf.1_Missense_Mutation_p.E236Q|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_001033678	NP_001028850	Q86TN4	TRPT1_HUMAN	tRNA phosphotransferase 1 isoform 1	236							tRNA 2'-phosphotransferase activity				0						CTCTGACACTCTGTCTCTTCA	0.398		NaN											0	0	0	0.016723	0	13	116									
FKBP2	2286	broad.mit.edu	37	11	64010754	64010754	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64010754C>T	uc001nyy.2	+	3	451	c.255C>T	c.(253-255)GTC>GTT	p.V85V	FKBP2_uc010rnh.1_Silent_p.V85V|FKBP2_uc001nyz.2_Silent_p.V85V	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	85	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						CAGGCCAGGTCATCAAGGGCT	0.622		NaN											0	0	0	0.004007	0	17	57									
PLCB3	5331	broad.mit.edu	37	11	64033975	64033975	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64033975C>G	uc001nzb.2	+	29	3365	c.3365C>G	c.(3364-3366)ACG>AGG	p.T1122R	PLCB3_uc009ypg.1_Missense_Mutation_p.T1122R|PLCB3_uc009yph.1_Missense_Mutation_p.T1055R|PLCB3_uc009ypi.2_Missense_Mutation_p.T1122R	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1122					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGGGAACTGACGGAGATTAAC	0.652		NaN											0	0	0	0.008291	0	9	66									
SLC22A12	116085	broad.mit.edu	37	11	64360326	64360326	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64360326G>A	uc001oam.1	+	2	1225	c.478G>A	c.(478-480)GCT>ACT	p.A160T	SLC22A12_uc009ypr.1_Missense_Mutation_p.A160T|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.A160T|SLC22A12_uc001oan.1_Missense_Mutation_p.A160T|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	160	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						TCTGGTGGGAGCTGCTGCGTG	0.632		NaN											0	0	0	0.014323	0	21	105									
ATG2A	23130	broad.mit.edu	37	11	64665359	64665359	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64665359C>T	uc001obx.2	-	35	5061	c.4946G>A	c.(4945-4947)GGA>GAA	p.G1649E	ATG2A_uc001obw.2_Missense_Mutation_p.G414E	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1649							protein binding			ovary(1)|central_nervous_system(1)	2						GTGTCCACCTCCTGGGGCCTC	0.697		NaN											0	0	0	0.004482	0	7	49									
PPP2R5B	5526	broad.mit.edu	37	11	64699064	64699064	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64699064A>G	uc001oby.2	+	10	1564	c.979A>G	c.(979-981)ACC>GCC	p.T327A	PPP2R5B_uc001obz.2_Missense_Mutation_p.T327A	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	327					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CTGGCCAAAAACCTGCACCCA	0.587		NaN											0	0	0	0.004672	0	3	16									
PPFIA1	8500	broad.mit.edu	37	11	70201868	70201868	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:70201868G>A	uc001opo.2	+	18	2637	c.2439G>A	c.(2437-2439)AAG>AAA	p.K813K	PPFIA1_uc001opn.1_Silent_p.K813K|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	813					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGTTTGGCAAGAAAGAAAAGG	0.547		NaN											0	0	0	0.007291	0	27	62									
RNF121	55298	broad.mit.edu	37	11	71668300	71668300	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:71668300G>C	uc001ora.2	+	2	431	c.91G>C	c.(91-93)GAG>CAG	p.E31Q	RNF121_uc001ord.2_Intron|RNF121_uc001orb.2_Intron|RNF121_uc009yst.2_Intron	NM_018320	NP_060790	Q9H920	RN121_HUMAN	ring finger protein 121	31						integral to membrane	zinc ion binding				0						CTCTCCAGAAGAGCAATGGAG	0.443		NaN											0	0	0	0.024334	0	21	103									
KDM4D	55693	broad.mit.edu	37	11	94731431	94731431	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:94731431C>T	uc001pfe.2	+	3	1727	c.895C>T	c.(895-897)CGA>TGA	p.R299*		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	299	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGCCACTCCGCGATGGATTGA	0.537		NaN											0	0	0	0.007413	0	19	81									
MMP10	4319	broad.mit.edu	37	11	102645984	102645984	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:102645984G>C	uc001phg.1	-	7	1023	c.1001C>G	c.(1000-1002)TCT>TGT	p.S334C		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	334	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TGATGGAAGAGAGGGCCAAAA	0.353		NaN											0	0	0	0.004007	0	15	74									
ARHGAP20	57569	broad.mit.edu	37	11	110582896	110582896	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:110582896G>C	uc001pkz.1	-	2	344	c.59C>G	c.(58-60)TCC>TGC	p.S20C	ARHGAP20_uc001pky.1_5'Flank|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	20					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCTGTCAGGGAAGAGGAGCG	0.483		NaN											0	0	0	0.001984	0	6	6									
TTC36	143941	broad.mit.edu	37	11	118399370	118399370	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:118399370G>C	uc001ptg.1	+	2	171	c.171G>C	c.(169-171)CAG>CAC	p.Q57H	TTC36_uc010ryb.1_RNA|TTC36_uc010ryc.1_5'UTR|TMEM25_uc010ryd.1_5'Flank|TMEM25_uc001ptk.3_5'Flank|TMEM25_uc010rye.1_5'Flank|TMEM25_uc001pth.2_5'Flank|TMEM25_uc009zad.2_5'Flank|TMEM25_uc001pti.2_5'Flank|TMEM25_uc010ryf.1_5'Flank|TMEM25_uc001ptl.2_5'Flank|TMEM25_uc001ptm.2_5'Flank	NM_001080441	NP_001073910	A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	57	TPR 1.						binding				0						TGGAGCTGCAGGGGGTGATGG	0.607		NaN											0	0	0	0.020292	0	14	77									
OR8D1	283159	broad.mit.edu	37	11	124180599	124180599	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:124180599C>T	uc010sag.1	-	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AGCTGGAGCTCTGCTTGCTGT	0.453		NaN											0	0	0	0.01441	0	61	132									
HYLS1	219844	broad.mit.edu	37	11	125769668	125769668	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:125769668G>A	uc009zbv.2	+	4	939	c.405G>A	c.(403-405)CTG>CTA	p.L135L	HYLS1_uc001qcx.3_Silent_p.L135L|PUS3_uc001qcy.2_Intron	NM_145014	NP_659451	Q96M11	HYLS1_HUMAN	hydrolethalus syndrome 1	135						centrosome|nucleus				upper_aerodigestive_tract(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		GACAAAGGCTGATGAATGTAC	0.383		NaN											0	0	0	0.01441	0	52	118									
NTM	50863	broad.mit.edu	37	11	132016342	132016342	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:132016342C>A	uc001qgp.2	+	2	998	c.334C>A	c.(334-336)CCT>ACT	p.P112T	NTM_uc001qgm.2_Missense_Mutation_p.P112T|NTM_uc010sch.1_Missense_Mutation_p.P103T|NTM_uc010sci.1_Missense_Mutation_p.P112T|NTM_uc010scj.1_Missense_Mutation_p.P71T|NTM_uc001qgo.2_Missense_Mutation_p.P112T|NTM_uc001qgq.2_Missense_Mutation_p.P112T	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	112	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane		p.P112H(1)		ovary(4)|central_nervous_system(1)|skin(1)	6						TGACGAGGGCCCTTACACCTG	0.577		NaN											1	0	1.49906e-05	0.020292	1.544e-05	12	88									
KLRB1	3820	broad.mit.edu	37	12	9752379	9752379	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:9752379G>T	uc010sgt.1	-	3	305	c.243C>A	c.(241-243)AGC>AGA	p.S81R		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B,	81	Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						TTTTATTCCTGCTCTGTTGAA	0.264		NaN											1	0	5.73435e-26	0.01441	6.34074e-26	42	127									
WBP11	51729	broad.mit.edu	37	12	14949871	14949871	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:14949871C>T	uc001rci.2	-	5	418	c.257G>A	c.(256-258)CGT>CAT	p.R86H		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	86	Potential.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						AAAGGTTTCACGCAGCTTTTT	0.338		NaN											0	0	0	0.01892	0	24	98									
RECQL	5965	broad.mit.edu	37	12	21624414	21624414	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:21624414G>C	uc001rex.2	-	14	1963	c.1615C>G	c.(1615-1617)CGT>GGT	p.R539G	RECQL_uc001rey.2_Missense_Mutation_p.R539G	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	539					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						AGATCTTCACGAGGAAGTGTG	0.388		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.007291	0	26	133									
ITPR2	3709	broad.mit.edu	37	12	26709193	26709193	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:26709193C>A	uc001rhg.2	-	36	5354	c.4937G>T	c.(4936-4938)AGA>ATA	p.R1646I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1646	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ACATCTTATTCTTGCATCGCT	0.458		NaN											1	0	1.14856e-27	0.01441	1.27295e-27	59	134									
ITPR2	3709	broad.mit.edu	37	12	26709224	26709224	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:26709224C>T	uc001rhg.2	-	36	5323	c.4906G>A	c.(4906-4908)GAA>AAA	p.E1636K		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1636	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AACAGCAGTTCTGGACTGTAC	0.473		NaN											0	0	0	0.01441	0	46	111									
OVCH1	341350	broad.mit.edu	37	12	29598224	29598224	+	Silent	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:29598224G>C	uc001rix.1	-	23	2868	c.2868C>G	c.(2866-2868)GTC>GTG	p.V956V		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	956	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GGACTTTCAAGACAATATAGC	0.353		NaN											0	0	0	0.007835	0	40	97									
C12orf35	55196	broad.mit.edu	37	12	32133998	32133998	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:32133998C>G	uc001rks.2	+	4	523	c.109C>G	c.(109-111)CAG>GAG	p.Q37E		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	37										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CACAACATCTCAGAGTTCTTT	0.393		NaN											0	0	0	0.012319	0	23	120									
C12orf44	60673	broad.mit.edu	37	12	52470629	52470629	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:52470629G>A	uc001rzu.3	+	4	787	c.312G>A	c.(310-312)CAG>CAA	p.Q104Q	C12orf44_uc009zmd.2_Silent_p.Q104Q|uc009zme.1_5'Flank	NM_021934	NP_068753	Q9BSB4	ATGA1_HUMAN	Atg13-interacting protein	104					autophagic vacuole assembly	pre-autophagosomal structure	identical protein binding|protein complex binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0978)		AGTTCTACCAGAAGAAGAAGT	0.592		NaN											0	0	0	0.00632	0	28	53									
KRT79	338785	broad.mit.edu	37	12	53216964	53216964	+	Silent	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:53216964G>C	uc001sbb.2	-	7	1236	c.1203C>G	c.(1201-1203)CTC>CTG	p.L401L	KRT79_uc001sba.2_Silent_p.L172L	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	401	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						GAGCATCCTTGAGTGCCAGCT	0.617		NaN											0	0	0	0.016522	0	24	43									
MFSD5	84975	broad.mit.edu	37	12	53646663	53646663	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:53646663C>A	uc001sci.1	+	2	235	c.44C>A	c.(43-45)TCC>TAC	p.S15Y	MFSD5_uc001sch.1_Missense_Mutation_p.S122Y	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	15	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						CTCCTGGCCTCCTGCCTGGGG	0.592		NaN											1	0	8.16277e-20	0.027894	8.96414e-20	42	65									
NCKAP1L	3071	broad.mit.edu	37	12	54902260	54902260	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:54902260C>T	uc001sgc.3	+	5	530	c.451C>T	c.(451-453)CGG>TGG	p.R151W	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.R101W	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	151					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GATTGAAGATCGGCGGATACT	0.423		NaN											0	0	0	0.01441	0	136	259									
NAB2	4665	broad.mit.edu	37	12	57485457	57485457	+	Silent	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:57485457T>C	uc001smz.2	+	2	1011	c.633T>C	c.(631-633)CCT>CCC	p.P211P		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	211					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTCCCCCCCTGCAGGGGGAG	0.711		NaN											0	0	0	0.020292	0	7	28									
PTPRB	5787	broad.mit.edu	37	12	70963557	70963557	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:70963557C>G	uc001swb.3	-	12	2908	c.2878G>C	c.(2878-2880)GAG>CAG	p.E960Q	PTPRB_uc010sto.1_Missense_Mutation_p.E960Q|PTPRB_uc010stp.1_Missense_Mutation_p.E870Q|PTPRB_uc001swc.3_Missense_Mutation_p.E1178Q|PTPRB_uc001swa.3_Missense_Mutation_p.E1090Q|PTPRB_uc001swd.3_Missense_Mutation_p.E1177Q|PTPRB_uc009zrr.1_Missense_Mutation_p.E1057Q	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	960	Fibronectin type-III 11.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AACGTGTGCTCAAAGACGTGC	0.542		NaN											0	0	0	0.012319	0	19	58									
PPP1R12A	4659	broad.mit.edu	37	12	80200075	80200075	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:80200075G>C	uc001syz.2	-	13	1961	c.1694C>G	c.(1693-1695)TCT>TGT	p.S565C	PPP1R12A_uc010suc.1_Missense_Mutation_p.S478C|PPP1R12A_uc001sza.2_Intron|PPP1R12A_uc010sud.1_Missense_Mutation_p.S565C|PPP1R12A_uc001szb.2_Missense_Mutation_p.S565C|PPP1R12A_uc001szc.2_Missense_Mutation_p.S565C	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	565	Ser/Thr-rich.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						TGGAACACTAGAACTAATCAA	0.388		NaN											0	0	0	0.01441	0	50	281									
PPFIA2	8499	broad.mit.edu	37	12	81746948	81746948	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:81746948C>G	uc001szo.1	-	17	2105	c.1944G>C	c.(1942-1944)ACG>ACC	p.T648T	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	574										ovary(3)|lung(2)|pancreas(1)	6						TCATGGCTAGCGTCTGGGCAT	0.383		NaN											0	0	0	0.019004	0	33	112									
IKBIP	121457	broad.mit.edu	37	12	99028127	99028127	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:99028127C>G	uc001tfv.2	-	2	354	c.244G>C	c.(244-246)GAA>CAA	p.E82Q	IKBIP_uc001tfw.2_Intron|IKBIP_uc001tfx.2_Missense_Mutation_p.E82Q	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	82					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TCATTGGTTTCTAGTTTCAGT	0.328		NaN											0	0	0	0.004482	0	9	55									
MMAB	326625	broad.mit.edu	37	12	110002954	110002954	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:110002954C>T	uc001tou.2	-	4	391	c.318G>A	c.(316-318)AAG>AAA	p.K106K	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Silent_p.K15K|MMAB_uc001tox.2_Silent_p.K54K	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	106					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGTATGGCCCTTTTCTGTGA	0.463		NaN											0	0	0	0.027894	0	38	120									
TBX5	6910	broad.mit.edu	37	12	114793706	114793706	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:114793706G>A	uc001tvo.2	-	9	1683	c.1188C>T	c.(1186-1188)ATC>ATT	p.I396I	TBX5_uc001tvp.2_Silent_p.I396I|TBX5_uc001tvq.2_Silent_p.I346I	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	396					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TGTTGCAGCTGATGTCCTCTA	0.632		NaN											0	0	0	0.00499	0	15	72									
C12orf49	79794	broad.mit.edu	37	12	117175649	117175649	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:117175649G>A	uc001tvz.1	-	1	195	c.57C>T	c.(55-57)CTC>CTT	p.L19L	RNFT2_uc009zwn.2_5'Flank|RNFT2_uc001twb.3_5'Flank|RNFT2_uc001twa.3_5'Flank|C12orf49_uc009zwm.1_Missense_Mutation_p.R42C	NM_024738	NP_079014	Q9H741	CL049_HUMAN	hypothetical protein LOC79794 precursor	19						extracellular region				ovary(1)	1	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		AGACCAGGGCGAGCACCCACC	0.542		NaN											0	0	0	0.004482	0	7	30									
SBNO1	55206	broad.mit.edu	37	12	123830066	123830066	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:123830066G>T	uc010tap.1	-	3	289	c.289C>A	c.(289-291)CCA>ACA	p.P97T	SBNO1_uc010tao.1_Missense_Mutation_p.P96T|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.P97T|SBNO1_uc001ueu.2_Missense_Mutation_p.P96T|SBNO1_uc001uev.2_Missense_Mutation_p.P95T|SBNO1_uc009zxy.1_Missense_Mutation_p.P62T	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	97							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CCCAAGGGTGGAAGATGATTT	0.378		NaN											1	0	1.05317e-09	0.020292	1.10848e-09	14	69									
CHFR	55743	broad.mit.edu	37	12	133420656	133420656	+	Silent	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:133420656C>A	uc001ulf.2	-	16	1920	c.1836G>T	c.(1834-1836)CTG>CTT	p.L612L	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Silent_p.L600L|CHFR_uc010tbs.1_Silent_p.L611L|CHFR_uc001uld.2_Silent_p.L571L|CHFR_uc010tbt.1_Silent_p.L520L	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	612					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		ACTGATAGGTCAGCTCACGGA	0.542		NaN											1	0	1.80694e-10	0.009535	1.9102e-10	28	31									
FAM123A	219287	broad.mit.edu	37	13	25744470	25744470	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:25744470C>G	uc001uqb.2	-	1	1388	c.1288G>C	c.(1288-1290)GAG>CAG	p.E430Q	FAM123A_uc001uqa.2_Missense_Mutation_p.E311Q|FAM123A_uc001uqc.2_Missense_Mutation_p.E311Q	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	430										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCGTCCACCTCGTCCGGGCTG	0.652		NaN											0	0	0	0.006214	0	9	22									
WASF3	10810	broad.mit.edu	37	13	27216530	27216530	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:27216530G>A	uc001uqv.2	+	3	348	c.123G>A	c.(121-123)CTG>CTA	p.L41L	WASF3_uc001uqw.2_Silent_p.L41L	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	41					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TACGCCAGCTGAGCAGTCTGA	0.418		NaN											0	0	0	0.01441	0	69	140									
FLT1	2321	broad.mit.edu	37	13	28880827	28880827	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:28880827G>A	uc001usb.3	-	29	4088	c.3803C>T	c.(3802-3804)TCG>TTG	p.S1268L	FLT1_uc010aap.2_Missense_Mutation_p.S273L|FLT1_uc010aaq.2_Missense_Mutation_p.S393L|FLT1_uc001usa.3_Missense_Mutation_p.S486L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1268	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AATCTTGAGCGAGGCCTTGGG	0.532		NaN											0	0	0	0.012319	0	22	45									
DCLK1	9201	broad.mit.edu	37	13	36445432	36445432	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:36445432G>A	uc001uvf.2	-	5	1102	c.869C>T	c.(868-870)TCA>TTA	p.S290L	uc001uvi.1_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	290	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CCTGCGGGATGATGAAGCTAT	0.507		NaN											0	0	0	0.01441	0	75	106									
ENOX1	55068	broad.mit.edu	37	13	43872592	43872592	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:43872592C>T	uc001uza.3	-	12	1636	c.1336G>A	c.(1336-1338)GAG>AAG	p.E446K	ENOX1_uc001uzb.3_Missense_Mutation_p.E446K|ENOX1_uc001uzc.3_Missense_Mutation_p.E446K|ENOX1_uc001uyz.3_Missense_Mutation_p.E55K	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	446	Potential.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		AGCTCCACCTCATTCCTGTAG	0.522		NaN											0	0	0	0.016723	0	13	151									
ZC3H13	23091	broad.mit.edu	37	13	46543642	46543642	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:46543642C>T	uc010tfw.1	-	13	3043	c.3037G>A	c.(3037-3039)GAT>AAT	p.D1013N	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.D1013N|ZC3H13_uc001vat.1_Missense_Mutation_p.D1013N	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1013	Lys-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		ATATCAGAATCACCTTTGGAT	0.373		NaN											0	0	0	0.008291	0	10	64									
UCHL3	7347	broad.mit.edu	37	13	76124114	76124114	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:76124114C>T	uc001vjq.2	+	2	75	c.45C>T	c.(43-45)GTC>GTT	p.V15V		NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	15					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		GTTTTCAGGTCACCAACCAGG	0.622		NaN									OREG0022446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	84	119									
SLITRK1	114798	broad.mit.edu	37	13	84453946	84453946	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:84453946C>T	uc001vlk.2	-	1	2583	c.1697G>A	c.(1696-1698)AGA>AAA	p.R566K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	566	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAAATCCTTTCTAAAGAAGTT	0.517		NaN											0	0	0	0.004482	0	8	41									
MYO16	23026	broad.mit.edu	37	13	109777464	109777464	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:109777464C>G	uc001vqt.1	+	30	3600	c.3474C>G	c.(3472-3474)ATC>ATG	p.I1158M	MYO16_uc010agk.1_Missense_Mutation_p.I1180M|MYO16_uc010tjh.1_Missense_Mutation_p.I670M	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1158	IQ.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TAAAAGTTATCAGAGGATTTT	0.383		NaN											0	0	0	0.007413	0	17	45									
MCF2L	23263	broad.mit.edu	37	13	113718683	113718683	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:113718683C>A	uc001vsu.2	+	6	748	c.726C>A	c.(724-726)GAC>GAA	p.D242E	MCF2L_uc001vsq.2_Missense_Mutation_p.D242E|MCF2L_uc010tjr.1_Missense_Mutation_p.D185E|MCF2L_uc001vsr.2_Missense_Mutation_p.D189E|MCF2L_uc001vss.3_Missense_Mutation_p.D183E|MCF2L_uc010tjs.1_Missense_Mutation_p.D183E|MCF2L_uc001vst.1_Missense_Mutation_p.D147E	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	215	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TGACCGAGGACCTGGGTGGGA	0.612		NaN											1	0	0.00621372	0.006214	0.00627899	9	73									
CMTM5	116173	broad.mit.edu	37	14	23846484	23846484	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:23846484G>A	uc010akm.2	+	1	468	c.24G>A	c.(22-24)CGG>CGA	p.R8R	CMTM5_uc001wjs.2_Silent_p.R8R|CMTM5_uc001wjt.2_Silent_p.R8R|CMTM5_uc010akn.2_Silent_p.R8R|CMTM5_uc001wju.2_Silent_p.R8R|CMTM5_uc010ako.2_RNA	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	8					chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GAGATCGCCGGGACCGGCACC	0.612		NaN											0	0	0	0.008291	0	9	54									
IRF9	10379	broad.mit.edu	37	14	24635333	24635333	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:24635333G>A	uc001wmq.2	+	9	1237	c.1110G>A	c.(1108-1110)ATG>ATA	p.M370I	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_Missense_Mutation_p.M154I	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	370					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		CAATACAGATGGAGCAGGCCT	0.592		NaN											0	0	0	0.020292	0	13	23									
NYNRIN	57523	broad.mit.edu	37	14	24878489	24878489	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:24878489G>A	uc001wpf.3	+	4	1807	c.1489G>A	c.(1489-1491)GAT>AAT	p.D497N		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	497					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TGAGCCGGGGGATCAAGGGAG	0.572		NaN											0	0	0	0.008291	0	9	37									
PCNX	22990	broad.mit.edu	37	14	71374675	71374675	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:71374675C>G	uc001xmo.2	+	1	554	c.108C>G	c.(106-108)CTC>CTG	p.L36L	PCNX_uc001xmn.3_Silent_p.L36L|PCNX_uc010are.1_Silent_p.L36L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	36	Helical; (Potential).					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CGCTGCACCTCTACCTGTGGC	0.687		NaN											0	0	0	0.004482	0	6	12									
HEATR4	399671	broad.mit.edu	37	14	73967257	73967257	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:73967257C>G	uc010tub.1	-	12	2605	c.2283G>C	c.(2281-2283)AAG>AAC	p.K761N	HEATR4_uc010tua.1_Missense_Mutation_p.K714N	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		GACTCACCATCTTGTCGCGGA	0.532		NaN											0	0	0	0.013114	0	41	35									
C14orf45	80127	broad.mit.edu	37	14	74523874	74523874	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:74523874C>T	uc010tup.1	+	11	1614	c.1491C>T	c.(1489-1491)ATC>ATT	p.I497I	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	497											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		AAGATAAAATCTTCATCACCC	0.398		NaN											0	0	0	0.007291	0	22	77									
DICER1	23405	broad.mit.edu	37	14	95569761	95569761	+	Silent	SNP	C	C	T	rs45562437	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:95569761C>T	uc001ydw.2	-	22	4154	c.3972G>A	c.(3970-3972)AAG>AAA	p.K1324K	DICER1_uc010avh.1_Silent_p.K222K|DICER1_uc001ydv.2_Silent_p.K1314K|DICER1_uc001ydx.2_Silent_p.K1324K|DICER1_uc001ydy.1_Silent_p.K176K	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1324	RNase III 1.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGATGGCATGCTTTAAAAAGG	0.428		NaN	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.014758	0	4	63									
UBE3A	7337	broad.mit.edu	37	15	25585264	25585264	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:25585264C>T	uc001zaq.2	-	10	2475	c.2475G>A	c.(2473-2475)ATG>ATA	p.M825I	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.M802I|UBE3A_uc001zas.2_Missense_Mutation_p.M822I|UBE3A_uc001zat.2_Missense_Mutation_p.M802I	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	825	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TGGCTATAATCATCTTTAATT	0.393		NaN											0	0	0	0.014323	0	22	88									
RYR3	6263	broad.mit.edu	37	15	33927868	33927868	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:33927868G>A	uc001zhi.2	+	26	3299	c.3229G>A	c.(3229-3231)GAG>AAG	p.E1077K	RYR3_uc010bar.2_Missense_Mutation_p.E1077K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1077	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTTCCGGGTAGAGCGATCTTA	0.522		NaN											0	0	0	0.004007	0	14	31									
ITPKA	3706	broad.mit.edu	37	15	41793928	41793928	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:41793928C>T	uc001znz.2	+	3	693	c.682C>T	c.(682-684)CGC>TGC	p.R228C		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	228					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TGACGCGCTGCGCGGCTGCGT	0.682		NaN											0	0	0	0.014758	0	5	13									
SPTBN5	51332	broad.mit.edu	37	15	42143103	42143103	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:42143103G>A	uc001zos.2	-	66	11098	c.10765C>T	c.(10765-10767)CCG>TCG	p.P3589S		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3624	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCTTCGGACGGTGCTGCAAAC	0.682		NaN											0	0	0	0.004482	0	7	7									
TP53BP1	7158	broad.mit.edu	37	15	43784619	43784619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:43784619G>A	uc001zrs.2	-	2	188	c.40C>T	c.(40-42)CAG>TAG	p.Q14*	TP53BP1_uc010udp.1_Nonsense_Mutation_p.Q14*|TP53BP1_uc001zrq.3_Nonsense_Mutation_p.Q19*|TP53BP1_uc001zrr.3_Nonsense_Mutation_p.Q19*|TP53BP1_uc010udq.1_Nonsense_Mutation_p.Q19*	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	14					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTATCTTGCTGAGAGAAATCT	0.453		NaN						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.009718	0	43	153									
MAP1A	4130	broad.mit.edu	37	15	43816516	43816516	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:43816516G>C	uc001zrt.2	+	4	3312	c.2845G>C	c.(2845-2847)GAG>CAG	p.E949Q		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	949						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGCAAACGTAGAGATGTCTGA	0.517		NaN											0	0	0	0.007413	0	19	115									
UNC13C	440279	broad.mit.edu	37	15	54308011	54308011	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:54308011T>A	uc002ack.2	+	1	2911	c.2911T>A	c.(2911-2913)TCT>ACT	p.S971T		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	971	Potential.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATTCGTCCTTCTTTCAAAGA	0.388		NaN											0	0	0	0.001984	0	5	13									
CELF6	60677	broad.mit.edu	37	15	72608198	72608198	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:72608198C>T	uc002auh.2	-	2	643	c.333G>A	c.(331-333)AAG>AAA	p.K111K	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Silent_p.K111K|CELF6_uc002aui.2_Missense_Mutation_p.D234N|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	111	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						CTGGCAGGGTCTTCTGCTCGT	0.637		NaN											0	0	0	0.004672	0	3	7									
FURIN	5045	broad.mit.edu	37	15	91423194	91423194	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:91423194C>T	uc002bpu.1	+	12	1572	c.1356C>T	c.(1354-1356)ATC>ATT	p.I452I		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	452					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGTGCATCATCGACATCCTCA	0.667		NaN											0	0	0	0.001984	0	7	24									
MSLNL	401827	broad.mit.edu	37	16	824500	824500	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:824500G>A	uc002cjz.1	-	8	1741	c.1741C>T	c.(1741-1743)CCT>TCT	p.P581S		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	230	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CAGGAGCCAGGGGGCCTTGTG	0.716		NaN											0	0	0	0.006214	0	7	3									
ZSCAN10	84891	broad.mit.edu	37	16	3140353	3140353	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:3140353C>T	uc002ctv.1	-	5	1005	c.917G>A	c.(916-918)CGC>CAC	p.R306H	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R224H|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R234H	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	306	C2H2-type 1.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGCCTTCAGGCGAGACAGCTG	0.642		NaN											0	0	0	0.007413	0	19	60									
ZNF263	10127	broad.mit.edu	37	16	3333838	3333838	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:3333838C>T	uc002cuq.2	+	1	352	c.20C>T	c.(19-21)TCC>TTC	p.S7F	ZNF263_uc010uww.1_Intron|ZNF263_uc002cup.2_Missense_Mutation_p.S7F	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	7					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						GGCCCGGGCTCCCAGGAACGG	0.682		NaN											0	0	0	0.004482	0	8	24									
GRIN2A	2903	broad.mit.edu	37	16	9857275	9857275	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:9857275G>A	uc002czo.3	-	13	4674	c.4126C>T	c.(4126-4128)CGC>TGC	p.R1376C	GRIN2A_uc010uym.1_Missense_Mutation_p.R1376C|GRIN2A_uc010uyn.1_Silent_p.N1104N|GRIN2A_uc002czr.3_Silent_p.N1261N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1376	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATAACCAAGCGTTGGTCATCC	0.562		NaN											0	0	0	0.016723	0	13	80									
SMG1	23049	broad.mit.edu	37	16	18823360	18823360	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:18823360C>G	uc002dfm.2	-	61	11074	c.10711G>C	c.(10711-10713)GCT>CCT	p.A3571P	SMG1_uc010bwb.2_Missense_Mutation_p.A3431P|SMG1_uc010bwa.2_Missense_Mutation_p.A2302P	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3571					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GGAGTATCAGCTGATGTAGCA	0.453		NaN											0	0	0	0.010729	0	10	66									
CLN3	1201	broad.mit.edu	37	16	28489120	28489120	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:28489120G>C	uc002dpo.2	-	14	1458	c.1135C>G	c.(1135-1137)CTG>GTG	p.L379V	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.L301V|CLN3_uc010vcu.1_Missense_Mutation_p.L279V|CLN3_uc002dpn.2_Missense_Mutation_p.L280V|CLN3_uc002dpm.2_Missense_Mutation_p.L325V|CLN3_uc010vcv.1_Missense_Mutation_p.L355V|CLN3_uc010byd.2_Intron|CLN3_uc002dpp.2_Missense_Mutation_p.L379V|CLN3_uc002dpt.1_Missense_Mutation_p.L279V|CLN3_uc002dpq.1_Missense_Mutation_p.L331V|CLN3_uc010bye.1_Missense_Mutation_p.L362V|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.L252V|CLN3_uc002dpu.1_Missense_Mutation_p.L277V	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	379					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						CCCTCATACAGAATGATCAGG	0.602		NaN											0	0	0	0.007413	0	19	76									
APOB48R	55911	broad.mit.edu	37	16	28507766	28507766	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:28507766G>C	uc002dqb.1	+	3	1387	c.1377G>C	c.(1375-1377)AAG>AAC	p.K459N	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	459	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TGCGTGGTAAGGAGGCTGAGA	0.642		NaN											0	0	0	0.004672	0	3	23									
SALL1	6299	broad.mit.edu	37	16	51173970	51173970	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:51173970C>T	uc010vgs.1	-	2	2194	c.2163G>A	c.(2161-2163)TTG>TTA	p.L721L	SALL1_uc010vgr.1_Silent_p.L624L|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	721	C2H2-type 3.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			AGTGCATTTTCAAGGCGCTCT	0.517		NaN											0	0	0	0.013537	0	13	61									
SALL1	6299	broad.mit.edu	37	16	51174338	51174338	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:51174338C>T	uc010vgs.1	-	2	1826	c.1795G>A	c.(1795-1797)GAG>AAG	p.E599K	SALL1_uc010vgr.1_Missense_Mutation_p.E502K|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	599					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTGGCTGACTCAGGGCCCCCG	0.602		NaN											0	0	0	0.006214	0	10	50									
CNGB1	1258	broad.mit.edu	37	16	58001085	58001085	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:58001085C>G	uc002emt.2	-	2	171	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	CNGB1_uc010cdh.2_Missense_Mutation_p.E36Q|CNGB1_uc002emu.2_Missense_Mutation_p.E36Q	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	36	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGTTCCACCTCCGCCTCCATC	0.652		NaN											0	0	0	0.020292	0	14	47									
VAC14	55697	broad.mit.edu	37	16	70796903	70796903	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:70796903G>A	uc002ezm.2	-	11	1444	c.1186C>T	c.(1186-1188)CAC>TAC	p.H396Y	VAC14_uc010cfw.2_Missense_Mutation_p.H162Y|VAC14_uc002ezn.2_Intron|uc002ezp.1_Intron	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	396					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				CCGTCGAGGTGAAGGGTCACT	0.577		NaN											0	0	0	0.001984	0	6	30									
FANCA	2175	broad.mit.edu	37	16	89809308	89809308	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:89809308G>A	uc002fou.1	-	37	3707	c.3665C>T	c.(3664-3666)CCG>CTG	p.P1222L	FANCA_uc010vpn.1_Missense_Mutation_p.P1222L|FANCA_uc010vpo.1_Missense_Mutation_p.P308L	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1222					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GAGCCAGTCCGGGTTGGGTGC	0.552		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.020292	0	14	31									
DBNDD1	79007	broad.mit.edu	37	16	90075252	90075252	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:90075252C>G	uc002fqf.1	-	3	447	c.259G>C	c.(259-261)GAG>CAG	p.E87Q	DBNDD1_uc002fqe.1_Missense_Mutation_p.E107Q|DBNDD1_uc002fqg.1_RNA	NM_001042610	NP_001036075	Q9H9R9	DBND1_HUMAN	dysbindin (dystrobrevin binding protein 1)	87						cytoplasm					0		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0275)		TCGGCCAGCTCCTGGTCCGAC	0.642		NaN											0	0	0	0.004672	0	3	14									
P2RX1	5023	broad.mit.edu	37	17	3819557	3819557	+	Translation_Start_Site	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:3819557C>T	uc002fww.2	-	1	404	c.-37G>A	c.(-39--35)CCGTG>CCATG		P2RX1_uc010ckm.1_Translation_Start_Site	NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1						platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		GCCCCCTGCACGGCCTCTGCT	0.677		NaN											0	0	0	0.010729	0	12	70									
KIF1C	10749	broad.mit.edu	37	17	4905823	4905823	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:4905823C>G	uc002gan.1	+	7	820	c.494C>G	c.(493-495)TCT>TGT	p.S165C		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	165	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						AGTCGGGGTTCTCTGCGGGTC	0.547		NaN											0	0	0	0.01441	0	146	64									
TP53	7157	broad.mit.edu	37	17	7574021	7574021	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:7574021C>A	uc002gim.2	-	10	1200	c.1006G>T	c.(1006-1008)GAG>TAG	p.E336*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.E204*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.E336*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	336	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E336*(5)|p.I332fs*5(1)|p.E336fs*12(1)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGAAGCGCTCACGCCCACGG	0.438		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	5.61819e-17	0.027356	6.1417e-17	26	12									
PIPOX	51268	broad.mit.edu	37	17	27370279	27370279	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:27370279G>A	uc002hdr.1	+	1	362	c.36G>A	c.(34-36)GTG>GTA	p.V12V		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	12	FAD (Potential).				tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	ACGCCATTGTGATTGGGGCGG	0.597		NaN											0	0	0	0.024245	0	15	60									
TMEM132E	124842	broad.mit.edu	37	17	32955650	32955650	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:32955650C>T	uc002hif.2	+	4	1125	c.797C>T	c.(796-798)TCG>TTG	p.S266L		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	266	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CATGTGACCTCGGAGCTGCTG	0.612		NaN											0	0	0	0.00308	0	7	38									
GPR179	440435	broad.mit.edu	37	17	36484690	36484690	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:36484690C>T	uc002hpz.2	-	11	4783	c.4762G>A	c.(4762-4764)GCC>ACC	p.A1588T		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1588	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCTGTTTTGGCAGGTGTTGCT	0.502		NaN											0	0	0	0.01441	0	123	274									
EIF1	10209	broad.mit.edu	37	17	39846394	39846394	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:39846394C>T	uc002hxj.2	+	3	414	c.250C>T	c.(250-252)CAG>TAG	p.Q84*	JUP_uc010wfs.1_Intron|EIF1_uc002hxk.2_RNA	NM_005801	NP_005792	P41567	EIF1_HUMAN	eukaryotic translation initiation factor 1	84					regulation of translational initiation|response to stress	cytoplasm	translation initiation factor activity				0		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			AGAAGTAATTCAGCTACAGGG	0.458		NaN											0	0	0	0.007413	0	15	108									
HAP1	9001	broad.mit.edu	37	17	39883363	39883363	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:39883363C>A	uc002hxm.1	-	10	1477	c.1465G>T	c.(1465-1467)GAG>TAG	p.E489*	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Nonsense_Mutation_p.E437*|HAP1_uc002hxo.1_Nonsense_Mutation_p.E420*|HAP1_uc002hxp.1_Nonsense_Mutation_p.E412*	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	489	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			CTGAGCTCCTCAGCCAGCGTC	0.577		NaN											1	0	0.004672	0.004672	0.004741	3	10									
GPATCH8	23131	broad.mit.edu	37	17	42475934	42475934	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:42475934C>T	uc002igw.1	-	8	3575	c.3511G>A	c.(3511-3513)GAG>AAG	p.E1171K	GPATCH8_uc002igv.1_Missense_Mutation_p.E1093K|GPATCH8_uc010wiz.1_Missense_Mutation_p.E1093K	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1171						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGTTCTTGCTCTTCCCCCCTT	0.517		NaN											0	0	0	0.023175	0	37	194									
SP2	6668	broad.mit.edu	37	17	45993797	45993797	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:45993797C>T	uc002imk.2	+	3	497	c.360C>T	c.(358-360)ATC>ATT	p.I120I	SP2_uc002iml.2_Silent_p.I113I|uc002imm.2_Intron	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	120					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0						CCACCATGATCAACAAAGGGA	0.507		NaN											0	0	0	0.012213	0	31	99									
TTLL6	284076	broad.mit.edu	37	17	46865191	46865191	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:46865191G>T	uc010wlo.1	-	12	1606	c.1571C>A	c.(1570-1572)GCT>GAT	p.A524D	TTLL6_uc002iob.2_Missense_Mutation_p.A217D|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.A277D|TTLL6_uc002iod.2_Missense_Mutation_p.A371D	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	476						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						CTCCTCCCGAGCCCTGGAAGC	0.532		NaN											1	0	1.50039e-11	0.012319	1.59665e-11	20	144									
ANKFN1	162282	broad.mit.edu	37	17	54450093	54450093	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:54450093G>C	uc002iun.1	+	6	732	c.697G>C	c.(697-699)GAG>CAG	p.E233Q		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	233	Potential.									large_intestine(1)|ovary(1)	2						TGCCCAGGTGGAGAATGAAGG	0.512		NaN											0	0	0	0.008361	0	32	130									
PRR11	55771	broad.mit.edu	37	17	57262920	57262920	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:57262920G>A	uc002ixf.1	+	4	478	c.399G>A	c.(397-399)CTG>CTA	p.L133L	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	133										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AGGAAGCACTGAAGGTTGGTA	0.224		NaN											0	0	0	0.020292	0	14	65									
DHX40	79665	broad.mit.edu	37	17	57684430	57684430	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:57684430G>C	uc002ixn.1	+	18	2384	c.2237G>C	c.(2236-2238)AGA>ACA	p.R746T	DHX40_uc010woe.1_Missense_Mutation_p.R669T|DHX40_uc010wof.1_Missense_Mutation_p.R261T	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	746							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AAAATGCAAAGAAGAAATGAT	0.388		NaN											0	0	0	0.007413	0	19	79									
KCNH6	81033	broad.mit.edu	37	17	61615899	61615899	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:61615899C>G	uc002jay.2	+	8	1910	c.1830C>G	c.(1828-1830)TTC>TTG	p.F610L	KCNH6_uc010wpl.1_Missense_Mutation_p.F487L|KCNH6_uc010wpm.1_Missense_Mutation_p.F610L|KCNH6_uc002jaz.1_Missense_Mutation_p.F557L	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	610	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCGTCAAGTTCAAGACCACCC	0.677		NaN											0	0	0	0.006214	0	10	9									
STRADA	92335	broad.mit.edu	37	17	61784042	61784042	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:61784042C>T	uc002jbm.2	-	10	970	c.811G>A	c.(811-813)GAA>AAA	p.E271K	STRADA_uc002jbn.2_Missense_Mutation_p.E213K|STRADA_uc002jbo.2_Missense_Mutation_p.E234K|STRADA_uc002jbp.2_Missense_Mutation_p.E234K|STRADA_uc002jbq.2_Missense_Mutation_p.E213K|STRADA_uc010wpq.1_Missense_Mutation_p.E227K|STRADA_uc010wpr.1_Missense_Mutation_p.E242K|STRADA_uc010ddw.2_Missense_Mutation_p.E242K|STRADA_uc002jbr.2_Missense_Mutation_p.E210K	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	271	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						TTGGCCAGTTCACAGGCTGTG	0.488		NaN											0	0	0	0.00874	0	39	203									
CACNG4	27092	broad.mit.edu	37	17	64961111	64961111	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:64961111C>T	uc002jft.1	+	1	99	c.84C>T	c.(82-84)ATC>ATT	p.I28I		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	28	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CCATCGCCATCGGCACCGACT	0.552		NaN											0	0	0	0.006214	0	8	21									
NOL11	25926	broad.mit.edu	37	17	65733721	65733721	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:65733721G>T	uc002jgd.1	+	12	1319	c.1316G>T	c.(1315-1317)GGA>GTA	p.G439V	NOL11_uc010wql.1_Missense_Mutation_p.G257V|NOL11_uc010deu.1_Missense_Mutation_p.G34V	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	439						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACAGTAACAGGACTTCTGGAA	0.423		NaN											1	0	1.3466e-33	0.01441	1.49588e-33	85	175									
BPTF	2186	broad.mit.edu	37	17	65908180	65908180	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:65908180G>C	uc002jgf.2	+	11	4241	c.4180G>C	c.(4180-4182)GAG>CAG	p.E1394Q	BPTF_uc002jge.2_Missense_Mutation_p.E1520Q	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1520					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGAAAATCGAGAGTCTGAAAA	0.299		NaN											0	0	0	0.014323	0	23	71									
METTL4	64863	broad.mit.edu	37	18	2544739	2544739	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:2544739A>C	uc002klh.3	-	7	1874	c.1094T>G	c.(1093-1095)TTT>TGT	p.F365C	METTL4_uc010dkj.2_Intron	NM_022840	NP_073751	Q8N3J2	METL4_HUMAN	methyltransferase like 4	365					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			kidney(1)|skin(1)	2						TGGGAACACAAATTCTCCTGA	0.403		NaN											0	0	0	0.021523	0	22	82									
LAMA3	3909	broad.mit.edu	37	18	21485566	21485566	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:21485566G>A	uc002kuq.2	+	52	6782	c.6696G>A	c.(6694-6696)ATG>ATA	p.M2232I	LAMA3_uc002kur.2_Missense_Mutation_p.M2176I|LAMA3_uc002kus.3_Missense_Mutation_p.M623I|LAMA3_uc002kut.3_Missense_Mutation_p.M567I	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2232	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGCCAAGATGACACAAAAGA	0.448		NaN											0	0	0	0.010771	0	44	98									
CDH2	1000	broad.mit.edu	37	18	25593832	25593832	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:25593832C>G	uc002kwg.2	-	3	673	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	CDH2_uc010xbn.1_Missense_Mutation_p.E41Q	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	72					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TCACTGCTCTCATATTGTACT	0.368		NaN											0	0	0	0.00632	0	29	69									
PIK3C3	5289	broad.mit.edu	37	18	39584503	39584503	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:39584503G>A	uc002lap.2	+	10	1226	c.1168G>A	c.(1168-1170)GAG>AAG	p.E390K	PIK3C3_uc010xcl.1_Missense_Mutation_p.E327K	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	390					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						GGCCGATGATGAGGTGCATTA	0.443		NaN								TSP Lung(28;0.18)			0	0	0	0.001984	0	7	32									
RNF165	494470	broad.mit.edu	37	18	44030341	44030341	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:44030341C>T	uc002lcb.1	+	5	749	c.698C>T	c.(697-699)TCC>TTC	p.S233F	RNF165_uc002lby.1_Missense_Mutation_p.S166F|RNF165_uc010dnn.1_Missense_Mutation_p.S29F	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	233							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		AGACACACCTCCGCCGTACGG	0.517		NaN											0	0	0	0.008871	0	18	87									
WDR7	23335	broad.mit.edu	37	18	54688024	54688024	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:54688024G>A	uc002lgk.1	+	27	4424	c.4213G>A	c.(4213-4215)GAT>AAT	p.D1405N	WDR7_uc002lgl.1_Missense_Mutation_p.D1372N	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1405	WD 9.									ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TTTTGCTCCTGATGGAAGATA	0.408		NaN											0	0	0	0.023175	0	34	143									
KCNG2	26251	broad.mit.edu	37	18	77659691	77659691	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:77659691G>A	uc010xfl.1	+	2	1276	c.1276G>A	c.(1276-1278)GAG>AAG	p.E426K		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	426	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		GGCCAGCCCCGAGCCGGCCCT	0.706		NaN											0	0	0	0.016723	0	10	13									
SEMA6B	10501	broad.mit.edu	37	19	4548448	4548448	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:4548448C>G	uc010duc.1	-	12	1319	c.1281G>C	c.(1279-1281)CTG>CTC	p.L427L	SEMA6B_uc010dud.2_Silent_p.L427L|SEMA6B_uc010xih.1_Silent_p.L427L	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	427	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACTCGAGTCAGCTGGTGCC	0.652		NaN											0	0	0	0.008871	0	19	22									
C3	718	broad.mit.edu	37	19	6707129	6707129	+	Missense_Mutation	SNP	G	G	A	rs117793540	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:6707129G>A	uc002mfm.2	-	17	2265	c.2203C>T	c.(2203-2205)CGG>TGG	p.R735W		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	735			R -> W (in AHUS5).		complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGCTGCCGCCGCAGCTCTGTG	0.687		NaN											0	0	0	0.016723	0	13	33									
GPR108	56927	broad.mit.edu	37	19	6731089	6731089	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:6731089C>T	uc002mfp.2	-	17	1514	c.1468G>A	c.(1468-1470)GTG>ATG	p.V490M	GPR108_uc010duv.2_Missense_Mutation_p.V41M|GPR108_uc002mfn.2_Missense_Mutation_p.V145M|GPR108_uc002mfo.3_Missense_Mutation_p.V248M|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	490	Helical; Name=7; (Potential).					integral to membrane					0						CCCGTGAGCACGAAGAAGGCC	0.677		NaN											0	0	0	0.001984	0	7	27									
KRI1	65095	broad.mit.edu	37	19	10670351	10670351	+	Missense_Mutation	SNP	C	C	T	rs45518133	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:10670351C>T	uc002moy.1	-	11	988	c.979G>A	c.(979-981)GTG>ATG	p.V327M	KRI1_uc002mow.1_Translation_Start_Site|KRI1_uc002mox.1_Missense_Mutation_p.V323M	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	327	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TTACGGCGCACGGAGGACGCG	0.622		NaN											0	0	0	0.016522	0	24	82									
DHPS	1725	broad.mit.edu	37	19	12792434	12792434	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:12792434G>T	uc002muh.1	-	1	244	c.147C>A	c.(145-147)TTC>TTA	p.F49L	DHPS_uc002muf.1_5'Flank|DHPS_uc002mug.1_5'Flank|DHPS_uc002mui.1_Missense_Mutation_p.F49L|DHPS_uc002muj.1_Missense_Mutation_p.F49L|DHPS_uc002muk.1_RNA|DHPS_uc010xmn.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	49					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	CGGTGGTGCCGAAGGCCTCCA	0.632		NaN											1	0	6.31663e-08	0.024245	6.5764e-08	14	44									
ASNA1	439	broad.mit.edu	37	19	12856314	12856314	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:12856314G>T	uc002muv.2	+	3	447	c.433G>T	c.(433-435)GCC>TCC	p.A145S	ASNA1_uc002muw.2_Missense_Mutation_p.A144S	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	145					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			ovary(2)	2					Adenosine triphosphate(DB00171)	CATCGATGAGGCCATGAGCTA	0.627		NaN											1	0	8.28177e-16	0.007413	8.97192e-16	20	55									
BEST2	54831	broad.mit.edu	37	19	12863496	12863496	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:12863496A>T	uc002mux.2	+	1	90	c.90A>T	c.(88-90)AAA>AAT	p.K30N		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	30	Helical; (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						GCATCTACAAACTCCTGTGGC	0.527		NaN											0	0	0	0.007413	0	18	31									
C19orf57	79173	broad.mit.edu	37	19	14000730	14000730	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:14000730C>G	uc002mxl.1	-	6	998	c.939G>C	c.(937-939)CAG>CAC	p.Q313H	C19orf57_uc002mxk.1_Missense_Mutation_p.Q195H|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	313					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGCTGGGGGTCTGCTGGGGGT	0.657		NaN											0	0	0	0.024245	0	15	21									
EPHX3	79852	broad.mit.edu	37	19	15338451	15338451	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:15338451C>G	uc002nap.2	-	7	1089	c.880G>C	c.(880-882)GAG>CAG	p.E294Q	EPHX3_uc002naq.2_Missense_Mutation_p.E294Q	NM_024794	NP_079070	Q9H6B9	EPHX3_HUMAN	abhydrolase domain containing 9 precursor	294						extracellular region	hydrolase activity				0						GTGGTCAGCTCCTGGGGTTCC	0.532		NaN											0	0	0	0.001984	0	7	39									
IL12RB1	3594	broad.mit.edu	37	19	18174691	18174691	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:18174691C>G	uc002nhw.1	-	13	1677	c.1613G>C	c.(1612-1614)AGC>ACC	p.S538T	IL12RB1_uc010xqb.1_Missense_Mutation_p.S538T|IL12RB1_uc002nhx.1_Missense_Mutation_p.S578T	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	538	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CTCACCGATGCTGAAGCGCTG	0.617		NaN											0	0	0	0.009096	0	3	29									
LSM14A	26065	broad.mit.edu	37	19	34685411	34685411	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:34685411G>A	uc002nvb.3	+	2	346	c.150G>A	c.(148-150)CCG>CCA	p.P50P	LSM14A_uc002nva.3_Silent_p.P50P|LSM14A_uc010xru.1_Silent_p.P50P	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	50					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					AAGACAGACCGACAGATCGTC	0.423		NaN											0	0	0	0.023175	0	35	197									
MLL4	9757	broad.mit.edu	37	19	36212267	36212267	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:36212267C>T	uc010eei.2	+	3	2018	c.2018C>T	c.(2017-2019)GCT>GTT	p.A673V		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	673	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCTTGGGGCTCCTGAAGCC	0.622		NaN											0	0	0	0.014758	0	5	6									
ZNF146	7705	broad.mit.edu	37	19	36727428	36727428	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:36727428C>G	uc002odq.3	+	4	1609	c.86C>G	c.(85-87)TCA>TGA	p.S29*	ZNF146_uc010eet.2_Nonsense_Mutation_p.S29*|ZNF146_uc010eeu.2_Nonsense_Mutation_p.S29*	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	29	C2H2-type 1.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					AGCCACAAATCAAACCTCACT	0.423		NaN											0	0	0	0.016522	0	23	76									
ZNF146	7705	broad.mit.edu	37	19	36728021	36728021	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:36728021C>G	uc002odq.3	+	4	2202	c.679C>G	c.(679-681)CTC>GTC	p.L227V	ZNF146_uc010eet.2_Missense_Mutation_p.L227V|ZNF146_uc010eeu.2_Missense_Mutation_p.L227V	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	227	Interaction with TERF2IP.|C2H2-type 8.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GAGCTCATCTCTCACTGTGCA	0.443		NaN											0	0	0	0.014323	0	21	154									
HNRNPUL1	11100	broad.mit.edu	37	19	41770565	41770565	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:41770565G>C	uc002oqb.3	+	1	446	c.157G>C	c.(157-159)GAA>CAA	p.E53Q	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Intron|HNRNPUL1_uc002oqa.3_Intron|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.E53Q|HNRNPUL1_uc002oqc.3_Intron|HNRNPUL1_uc002oqe.3_Missense_Mutation_p.E53Q|HNRNPUL1_uc002oqd.3_5'UTR|HNRNPUL1_uc010ehn.2_5'Flank|HNRNPUL1_uc010eho.2_5'Flank|HNRNPUL1_uc010xvy.1_5'Flank|HNRNPUL1_uc010ehl.1_Intron	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	53	Necessary for interaction with HRMT1L1.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CGCCGACGACGAACCGGGGCG	0.736		NaN											0	0	0	0.004482	0	6	19									
LIPE	3991	broad.mit.edu	37	19	42930623	42930623	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:42930623C>T	uc002otr.2	-	1	956	c.679G>A	c.(679-681)GAG>AAG	p.E227K	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	227					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GTGACCCACTCAGAAAGTGCC	0.493		NaN											0	0	0	0.01441	0	90	71									
NLRP4	147945	broad.mit.edu	37	19	56382202	56382202	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:56382202C>T	uc002qmd.3	+	7	2786	c.2364C>T	c.(2362-2364)TTC>TTT	p.F788F	NLRP4_uc002qmf.2_Silent_p.F713F|NLRP4_uc010etf.2_Silent_p.F563F	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	788							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGTTGGCTTTCTGCCACCTCA	0.483		NaN											0	0	0	0.01441	0	59	48									
NOL10	79954	broad.mit.edu	37	2	10799346	10799346	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:10799346C>G	uc002raq.2	-	10	833	c.708G>C	c.(706-708)TTG>TTC	p.L236F	NOL10_uc010yje.1_Missense_Mutation_p.L210F|NOL10_uc010yjf.1_Missense_Mutation_p.L186F|NOL10_uc002rap.2_Missense_Mutation_p.L236F|NOL10_uc002rar.2_Missense_Mutation_p.L86F	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	236	WD 3.					nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		CATTAAATTTCAAAGCAGAGA	0.373		NaN											0	0	0	0.001984	0	5	17									
MYCN	4613	broad.mit.edu	37	2	16082556	16082556	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:16082556G>A	uc002rci.2	+	2	670	c.370G>A	c.(370-372)GAG>AAG	p.E124K	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Missense_Mutation_p.E116K	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	124					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CTCCGCCCGCGAGAAGCTGGA	0.642		NaN	A		neuroblastoma								0	0	0	0.006122	0	14	14									
HADHA	3030	broad.mit.edu	37	2	26437925	26437925	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:26437925C>G	uc002rgy.2	-	8	926	c.796G>C	c.(796-798)GAA>CAA	p.E266Q	HADHA_uc010yks.1_Missense_Mutation_p.E179Q|HADHA_uc010ykt.1_Missense_Mutation_p.E179Q	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	266					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TACTCACTTTCCACCAATCCC	0.358		NaN											0	0	0	0.01441	0	74	146									
TMEM214	54867	broad.mit.edu	37	2	27258520	27258520	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:27258520G>A	uc002ria.3	+	4	671	c.561G>A	c.(559-561)GCG>GCA	p.A187A	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Intron	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	187						integral to membrane	protein binding				0						GGCTGCTGGCGAAGGCAGCAG	0.562		NaN											0	0	0	0.013114	0	48	98									
CAD	790	broad.mit.edu	37	2	27447627	27447627	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:27447627G>A	uc002rji.2	+	10	1431	c.1269G>A	c.(1267-1269)CTG>CTA	p.L423L	CAD_uc010eyw.2_Silent_p.L423L	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	423	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TTAAGGCCCTGAAGGAGGAAA	0.483		NaN											0	0	0	0.009718	0	43	212									
C2orf71	388939	broad.mit.edu	37	2	29297062	29297062	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:29297062C>G	uc002rmt.1	-	1	66	c.66G>C	c.(64-66)TTG>TTC	p.L22F		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	22					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						TGGGCTTTTTCAAGAACTGAA	0.493		NaN											0	0	0	0.024245	0	15	100									
CLIP4	79745	broad.mit.edu	37	2	29366627	29366627	+	Missense_Mutation	SNP	C	C	G	rs138901368	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:29366627C>G	uc002rmv.2	+	7	940	c.701C>G	c.(700-702)CCG>CGG	p.P234R	CLIP4_uc002rmu.2_Missense_Mutation_p.P234R|CLIP4_uc010ezm.1_Missense_Mutation_p.P234R|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.P216R	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	234										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTAGATATGCCGTTAGAGATG	0.453		NaN											0	0	0	0.009535	0	30	145									
CEBPZ	10153	broad.mit.edu	37	2	37450318	37450318	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:37450318G>A	uc002rpz.2	-	3	1906	c.1876C>T	c.(1876-1878)CAT>TAT	p.H626Y		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	626					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				TATACCGGATGATCATCTAGT	0.343		NaN											0	0	0	0.01441	0	55	65									
PLEK	5341	broad.mit.edu	37	2	68607517	68607517	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:68607517G>C	uc002sen.3	+	2	262	c.100G>C	c.(100-102)GAA>CAA	p.E34Q	PLEK_uc010fde.2_Missense_Mutation_p.E34Q	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	34	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGATGGAATTGAATTCTATAA	0.453		NaN											0	0	0	0.01441	0	53	47									
C2orf65	130951	broad.mit.edu	37	2	74834257	74834257	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:74834257G>A	uc002smy.2	-	4	637	c.520C>T	c.(520-522)CAG>TAG	p.Q174*	C2orf65_uc010ysa.1_Nonsense_Mutation_p.Q174*|C2orf65_uc002smz.2_Nonsense_Mutation_p.Q174*	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	174					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						TCAACGACCTGAAACCTCCTG	0.443		NaN											0	0	0	0.01892	0	24	135									
C2orf89	129293	broad.mit.edu	37	2	85066332	85066332	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:85066332C>G	uc010ysl.1	-	4	1021	c.932G>C	c.(931-933)CGG>CCG	p.R311P	C2orf89_uc002sou.3_Missense_Mutation_p.R262P|C2orf89_uc002sov.2_RNA|C2orf89_uc010fgc.1_Missense_Mutation_p.R311P	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	311	Extracellular (Potential).					integral to membrane				ovary(1)	1						GGCCTTCACCCGCTTCCCTAT	0.527		NaN											0	0	0	0.012319	0	20	52									
ZNF514	84874	broad.mit.edu	37	2	95815563	95815563	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:95815563G>A	uc002sue.1	-	5	1041	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	ZNF514_uc002sud.1_Nonsense_Mutation_p.Q296*	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	223	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGACATCGCTGATGGCGCCTA	0.438		NaN											0	0	0	0.01441	0	48	178									
NPAS2	4862	broad.mit.edu	37	2	101584864	101584864	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:101584864C>T	uc002tap.1	+	11	1315	c.1029C>T	c.(1027-1029)TTC>TTT	p.F343F	NPAS2_uc010yvt.1_Silent_p.F408F	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	343	PAC.				central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						AGCCCGAGTTCATCGTGTGCA	0.612		NaN											0	0	0	0.012319	0	19	79									
IL18RAP	8807	broad.mit.edu	37	2	103059778	103059778	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:103059778G>A	uc002tbx.2	+	8	1399	c.915G>A	c.(913-915)GCG>GCA	p.A305A	IL18RAP_uc010fiz.2_Silent_p.A163A	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	305	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						TACCTGAGGCGAAAAGGTAAG	0.408		NaN											0	0	0	0.010729	0	9	53									
EPB41L5	57669	broad.mit.edu	37	2	120833065	120833065	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:120833065C>G	uc002tmg.2	+	6	547	c.421C>G	c.(421-423)CTT>GTT	p.L141V	EPB41L5_uc010flk.2_Missense_Mutation_p.L141V|EPB41L5_uc010fll.2_Missense_Mutation_p.L141V|EPB41L5_uc002tmh.3_Missense_Mutation_p.L141V|EPB41L5_uc010flm.2_5'Flank	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	141	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						TTTATTTGTTCTTCAGTTAAA	0.284		NaN											0	0	0	0.020292	0	14	24									
WDR33	55339	broad.mit.edu	37	2	128520696	128520696	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:128520696C>G	uc002tpg.1	-	7	847	c.664G>C	c.(664-666)GAT>CAT	p.D222H	WDR33_uc002tph.1_Missense_Mutation_p.D222H	NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	222	WD 3.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GTGCCGTCATCAGAGCATGTA	0.408		NaN											0	0	0	0.024334	0	25	105									
NEB	4703	broad.mit.edu	37	2	152394433	152394433	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:152394433G>A	uc010fnx.2	-	112	16143	c.15952C>T	c.(15952-15954)CGT>TGT	p.R5318C	NEB_uc002txr.2_Missense_Mutation_p.R1741C	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5318	Nebulin 145.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGCTCTGGACGATCAGGAATG	0.403		NaN											0	0	0	0.008291	0	9	42									
ACVR1C	130399	broad.mit.edu	37	2	158397605	158397605	+	Missense_Mutation	SNP	C	C	G	rs149435555		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:158397605C>G	uc002tzk.3	-	7	1465	c.1222G>C	c.(1222-1224)GGA>CGA	p.G408R	ACVR1C_uc002tzl.3_Missense_Mutation_p.G328R|ACVR1C_uc010fof.2_Missense_Mutation_p.G251R|ACVR1C_uc010foe.2_Missense_Mutation_p.G358R	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	408	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						ATTTTACCTCCGACTGAACAC	0.373		NaN											0	0	0	0.021022	0	33	181									
C2orf77	129881	broad.mit.edu	37	2	170502386	170502386	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:170502386G>A	uc002ufe.2	-	9	1718	c.1624C>T	c.(1624-1626)CAA>TAA	p.Q542*		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	542											0						TTTGACTTTTGAAAATTATAT	0.348		NaN											0	0	0	0.006122	0	19	58									
TTN	7273	broad.mit.edu	37	2	179471896	179471896	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:179471896C>T	uc010zfg.1	-	227	45953	c.45729G>A	c.(45727-45729)TGG>TGA	p.W15243*	uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.W8938*|TTN_uc010zfi.1_Nonsense_Mutation_p.W8871*|TTN_uc010zfj.1_Nonsense_Mutation_p.W8746*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16170							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGTTGTCTCCAAGTATGCA	0.393		NaN											0	0	0	0.012213	0	32	175									
TTN	7273	broad.mit.edu	37	2	179639030	179639030	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:179639030G>C	uc010zfg.1	-	30	7185	c.6961C>G	c.(6961-6963)CAG>GAG	p.Q2321E	TTN_uc010zfh.1_Missense_Mutation_p.Q2275E|TTN_uc010zfi.1_Missense_Mutation_p.Q2275E|TTN_uc010zfj.1_Missense_Mutation_p.Q2275E|TTN_uc002unb.2_Missense_Mutation_p.Q2321E|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2321							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGAGGTTCTGACGTCCACGA	0.403		NaN											0	0	0	0.021523	0	24	121									
ITGAV	3685	broad.mit.edu	37	2	187514604	187514604	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:187514604C>G	uc002upq.2	+	14	1665	c.1389C>G	c.(1387-1389)ATC>ATG	p.I463M	ITGAV_uc010frs.2_Missense_Mutation_p.I427M|ITGAV_uc010zfv.1_Missense_Mutation_p.I417M	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	463	FG-GAP 7.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ATCGAGCTATCTTATACAGGT	0.289		NaN											0	0	0	0.001984	0	6	49									
ALS2CR8	79800	broad.mit.edu	37	2	203825996	203825996	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:203825996G>C	uc002uzo.2	+	8	959	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	ALS2CR8_uc002uzn.2_Missense_Mutation_p.E125Q|ALS2CR8_uc002uzm.2_Missense_Mutation_p.E227Q|ALS2CR8_uc010zhy.1_Intron|ALS2CR8_uc010zhz.1_Intron|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.E151Q|ALS2CR8_uc010zib.1_Missense_Mutation_p.E151Q|ALS2CR8_uc010zic.1_Missense_Mutation_p.E139Q|ALS2CR8_uc002uzp.2_Missense_Mutation_p.E227Q	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	227										large_intestine(1)|ovary(1)	2						CTGTGTAAGTGAGACTGAATT	0.413		NaN											0	0	0	0.016522	0	22	41									
ALS2CR8	79800	broad.mit.edu	37	2	203826043	203826043	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:203826043G>A	uc002uzo.2	+	8	1006	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	ALS2CR8_uc002uzn.2_Silent_p.Q140Q|ALS2CR8_uc002uzm.2_Silent_p.Q242Q|ALS2CR8_uc010zhy.1_Intron|ALS2CR8_uc010zhz.1_Intron|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Silent_p.Q166Q|ALS2CR8_uc010zib.1_Silent_p.Q166Q|ALS2CR8_uc010zic.1_Silent_p.Q154Q|ALS2CR8_uc002uzp.2_Silent_p.Q242Q	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	242										large_intestine(1)|ovary(1)	2						AGCAAACACAGAGTGTTTGGG	0.448		NaN											0	0	0	0.010504	0	20	41									
NDUFS1	4719	broad.mit.edu	37	2	207009731	207009731	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:207009731C>T	uc002vbe.2	-	9	884	c.757G>A	c.(757-759)GTA>ATA	p.V253I	NDUFS1_uc010ziq.1_Missense_Mutation_p.V267I|NDUFS1_uc010zir.1_Missense_Mutation_p.V217I|NDUFS1_uc010zis.1_Missense_Mutation_p.V196I|NDUFS1_uc010zit.1_Missense_Mutation_p.V142I|NDUFS1_uc010ziu.1_Missense_Mutation_p.V137I	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	253					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	GCATCCATTACATCAATGGAT	0.378		NaN											0	0	0	0.020292	0	14	73									
AAMP	14	broad.mit.edu	37	2	219129789	219129789	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219129789C>G	uc002vhk.2	-	10	1267	c.1183G>C	c.(1183-1185)GAC>CAC	p.D395H	AAMP_uc002vhj.2_Missense_Mutation_p.D376H|AAMP_uc010fvo.2_Missense_Mutation_p.D395H|AAMP_uc002vhl.2_Missense_Mutation_p.D396H	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	395	WD 7.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCGGTAGTCAGTAAGCAGG	0.607		NaN											0	0	0	0.010818	0	33	156									
PNKD	25953	broad.mit.edu	37	2	219209680	219209680	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219209680G>A	uc002vhn.2	+	10	1278	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	PNKD_uc002vhq.2_Silent_p.L354L	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	378	Substrate (By similarity).					membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCGCCGGCTGAAGGATATGC	0.682		NaN											0	0	0	0.020292	0	14	42									
STK36	27148	broad.mit.edu	37	2	219544683	219544683	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219544683C>A	uc002viu.2	+	9	1282	c.1016C>A	c.(1015-1017)GCC>GAC	p.A339D	STK36_uc002viv.2_Missense_Mutation_p.A339D	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	339					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CCTGGCACAGCCCCTCTGCCC	0.577		NaN											1	0	3.99206e-14	0.007413	4.2957e-14	20	103									
CYP27A1	1593	broad.mit.edu	37	2	219679343	219679343	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219679343C>T	uc002viz.3	+	8	1773	c.1339C>T	c.(1339-1341)CAC>TAC	p.H447Y		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	447					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	CTTCCAGCCCCACCGCTGGCT	0.607		NaN											0	0	0	0.010729	0	10	65									
SCG2	7857	broad.mit.edu	37	2	224463499	224463499	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:224463499G>A	uc002vnm.2	-	2	635	c.502C>T	c.(502-504)CCT>TCT	p.P168S		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	168					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCATACATAGGAGGGAATTGC	0.403		NaN											0	0	0	0.017118	0	36	165									
TRIP12	9320	broad.mit.edu	37	2	230656630	230656630	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:230656630C>A	uc002vpw.1	-	28	4251	c.4142G>T	c.(4141-4143)AGC>ATC	p.S1381I	TRIP12_uc002vpx.1_Missense_Mutation_p.S1429I|TRIP12_uc002vpy.1_Missense_Mutation_p.S1111I	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1381					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TAGAGGATTGCTCTCATCATC	0.383		NaN											1	0	6.21074e-16	0.011902	6.75875e-16	39	218									
NCL	4691	broad.mit.edu	37	2	232326368	232326368	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:232326368C>T	uc002vru.2	-	3	637	c.496G>A	c.(496-498)GAT>AAT	p.D166N	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	166	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		tcatcttcatcctcatcctcg	0.239		NaN											0	0	0	0.007413	0	20	24									
IQCA1	79781	broad.mit.edu	37	2	237396819	237396819	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:237396819T>C	uc002vvz.1	-	4	654	c.472A>G	c.(472-474)AGT>GGT	p.S158G	IQCA1_uc002vwb.2_Missense_Mutation_p.S165G|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.S158G	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	158							ATP binding			ovary(1)	1						AAAGGGATACTCTTTACAGGG	0.398		NaN											0	0	0	0.014758	0	5	20									
RBM44	375316	broad.mit.edu	37	2	238726129	238726129	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:238726129C>T	uc002vxi.3	+	3	702	c.570C>T	c.(568-570)CAC>CAT	p.H190H		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	189							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGGAATATCACAGTGCAGAAG	0.333		NaN											0	0	0	0.004482	0	8	26									
PER2	8864	broad.mit.edu	37	2	239167208	239167208	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:239167208C>T	uc002vyc.2	-	15	1942	c.1705G>A	c.(1705-1707)GAG>AAG	p.E569K	PER2_uc010znv.1_Missense_Mutation_p.E569K	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	569	CSNK1E binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GCCAACTCCTCGGGGAAGCTG	0.552		NaN											0	0	0	0.008291	0	11	47									
TGM3	7053	broad.mit.edu	37	20	2320505	2320505	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:2320505G>A	uc002wfx.3	+	12	1903	c.1806G>A	c.(1804-1806)CTG>CTA	p.L602L		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	602					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	CATAGGTGCTGAACGAGGCTC	0.637		NaN											0	0	0	0.00308	0	6	17									
FAM113A	64773	broad.mit.edu	37	20	2819730	2819730	+	Splice_Site	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:2819730T>C	uc002wgz.1	-	4	702	c.205_splice	c.e4-1	p.G69_splice	FAM113A_uc002whb.1_Intron|FAM113A_uc002wha.1_Splice_Site|FAM113A_uc010zqa.1_5'UTR|FAM113A_uc002whc.1_Intron|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773								hydrolase activity|protein binding			ovary(2)	2						CAGCTCCCCCTACCCACCCCC	0.652		NaN											0	0	0	0.009096	0	3	19									
TRMT6	51605	broad.mit.edu	37	20	5923084	5923084	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:5923084T>C	uc002wmh.1	-	7	1138	c.1016A>G	c.(1015-1017)AAA>AGA	p.K339R	TRMT6_uc010zra.1_Missense_Mutation_p.K169R|TRMT6_uc010gbn.1_Missense_Mutation_p.K169R|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	339					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						ATAATCTTTTTTGCTTCCTCT	0.453		NaN											0	0	0	0.01441	0	78	50									
RRBP1	6238	broad.mit.edu	37	20	17599273	17599273	+	Missense_Mutation	SNP	C	C	T	rs149077359		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:17599273C>T	uc002wpv.1	-	21	2782	c.2428G>A	c.(2428-2430)GAA>AAA	p.E810K	RRBP1_uc010zrp.1_5'UTR|RRBP1_uc002wpt.1_Missense_Mutation_p.E180K|RRBP1_uc002wpu.2_Missense_Mutation_p.E584K|RRBP1_uc002wpw.1_Missense_Mutation_p.E810K|RRBP1_uc010gcl.1_Missense_Mutation_p.E584K	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1243	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						TTCTGGGCTTCGCTCTTGGCG	0.552		NaN											0	0	0	0.016522	0	22	50									
SLC24A3	57419	broad.mit.edu	37	20	19566112	19566112	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:19566112G>C	uc002wrl.2	+	6	733	c.536G>C	c.(535-537)GGA>GCA	p.G179A		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	179	Extracellular (Potential).|Alpha-1.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						GGCGATGTGGGAGTTGGCACC	0.547		NaN											0	0	0	0.011902	0	42	154									
C20orf185	359710	broad.mit.edu	37	20	31654681	31654681	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:31654681G>A	uc002wym.1	+	9	976	c.976G>A	c.(976-978)GAG>AAG	p.E326K		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	326					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						TTTGCTCCCTGAGGTGAGTGA	0.358		NaN											0	0	0	0.008361	0	29	93									
TOP1	7150	broad.mit.edu	37	20	39741425	39741425	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:39741425G>A	uc002xjl.2	+	14	1558	c.1312G>A	c.(1312-1314)GAG>AAG	p.E438K	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	438					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TTTACAGGGTGAGAAGGACTG	0.373		NaN	T	NUP98	AML*								0	0	0	0.00308	0	8	53									
NCOA5	57727	broad.mit.edu	37	20	44692158	44692158	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:44692158C>T	uc002xrd.2	-	6	1519	c.991G>A	c.(991-993)GAG>AAG	p.E331K	NCOA5_uc002xrc.2_Missense_Mutation_p.E219K|NCOA5_uc002xre.2_Missense_Mutation_p.E331K	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				ACTCCCTCCTCAGGGCCTCCT	0.577		NaN											0	0	0	0.001984	0	7	63									
ZNFX1	57169	broad.mit.edu	37	20	47887564	47887564	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:47887564G>C	uc002xui.2	-	3	1032	c.785C>G	c.(784-786)TCT>TGT	p.S262C		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	262							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTCCTGCACAGAGCTGGCAGG	0.507		NaN											0	0	0	0.021523	0	26	107									
ZNF831	128611	broad.mit.edu	37	20	57828035	57828035	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:57828035C>G	uc002yan.2	+	4	4030	c.4030C>G	c.(4030-4032)CTG>GTG	p.L1344V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1344						intracellular	nucleic acid binding|zinc ion binding	p.L1344L(1)		skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCTTGCAGGTCTGAATCTGCA	0.458		NaN											0	0	0	0.01892	0	25	57									
ZNF831	128611	broad.mit.edu	37	20	57829687	57829687	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:57829687C>T	uc002yan.2	+	5	4923	c.4923C>T	c.(4921-4923)GCC>GCT	p.A1641A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1641						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TTCCTGAAGCCCCTTCTAAAT	0.463		NaN											0	0	0	0.01441	0	48	88									
LSM14B	149986	broad.mit.edu	37	20	60704841	60704841	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:60704841G>A	uc010gjy.1	+	4	634	c.428G>A	c.(427-429)GGA>GAA	p.G143E	LSM14B_uc010gjx.1_Missense_Mutation_p.G169E|LSM14B_uc002ybv.2_Missense_Mutation_p.G143E|LSM14B_uc010gjz.1_Missense_Mutation_p.G99E|LSM14B_uc010zzz.1_Missense_Mutation_p.G63E	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	143					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CTCAATTCAGGAGCTGGTTTT	0.498		NaN											0	0	0	0.014758	0	5	6									
LAMA5	3911	broad.mit.edu	37	20	60908513	60908513	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:60908513C>T	uc002ycq.2	-	25	3113	c.3046G>A	c.(3046-3048)GCA>ACA	p.A1016T		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1016	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGTAGTATGCGCTAGGCAGC	0.682		NaN											0	0	0	0.014758	0	5	29									
TIAM1	7074	broad.mit.edu	37	21	32559388	32559388	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:32559388G>A	uc002yow.1	-	15	3063	c.2591C>T	c.(2590-2592)TCT>TTT	p.S864F	TIAM1_uc011adk.1_Missense_Mutation_p.S864F|TIAM1_uc011adl.1_Missense_Mutation_p.S804F	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	864	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TTCTTCCACAGAAGAAAGTGA	0.458		NaN											0	0	0	0.01441	0	44	334									
HUNK	30811	broad.mit.edu	37	21	33296930	33296930	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:33296930C>T	uc002yph.2	+	2	772	c.412C>T	c.(412-414)CTG>TTG	p.L138L		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	138	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CAGCTACTACCTGGTCATGGA	0.532		NaN											0	0	0	0.011902	0	42	150									
MORC3	23515	broad.mit.edu	37	21	37741729	37741729	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:37741729C>T	uc002yvi.2	+	15	2139	c.2063C>T	c.(2062-2064)TCT>TTT	p.S688F		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	688	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						ACCGATAAATCTGCAGATGAT	0.413		NaN											0	0	0	0.01441	0	48	37									
TTC3	7267	broad.mit.edu	37	21	38461129	38461129	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:38461129G>T	uc002yvz.2	+	5	474	c.369G>T	c.(367-369)AAG>AAT	p.K123N	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Missense_Mutation_p.K123N|TTC3_uc002ywb.2_Missense_Mutation_p.K123N|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Missense_Mutation_p.K123N	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	123					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TAAATTTGAAGAAACTACAAC	0.323		NaN											1	0	3.45872e-05	0.004007	3.53215e-05	15	62									
RIPK4	54101	broad.mit.edu	37	21	43161677	43161677	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:43161677C>T	uc002yzn.1	-	8	1724	c.1676G>A	c.(1675-1677)CGA>CAA	p.R559Q		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	559						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GTCCACGCCTCGGCGCAGCAG	0.662		NaN											0	0	0	0.006214	0	10	95									
TRPM2	7226	broad.mit.edu	37	21	45837924	45837924	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:45837924C>T	uc002zet.1	+	22	3474	c.3261C>T	c.(3259-3261)CTC>CTT	p.L1087L	TRPM2_uc002zeu.1_Silent_p.L1087L|TRPM2_uc002zew.1_Silent_p.L1087L|TRPM2_uc010gpt.1_Silent_p.L1087L|TRPM2_uc002zex.1_Silent_p.L873L|TRPM2_uc002zey.1_Silent_p.L600L|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1087	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCATCCTCCTCAGCCACCTGC	0.502		NaN											0	0	0	0.01892	0	22	234									
TRPM2	7226	broad.mit.edu	37	21	45837945	45837945	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:45837945C>G	uc002zet.1	+	22	3495	c.3282C>G	c.(3280-3282)ATC>ATG	p.I1094M	TRPM2_uc002zeu.1_Missense_Mutation_p.I1094M|TRPM2_uc002zew.1_Missense_Mutation_p.I1094M|TRPM2_uc010gpt.1_Missense_Mutation_p.I1094M|TRPM2_uc002zex.1_Missense_Mutation_p.I880M|TRPM2_uc002zey.1_Missense_Mutation_p.I607M|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1094	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGCTCTTCATCAAGAGGGTGG	0.512		NaN											0	0	0	0.024334	0	23	226									
COL18A1	80781	broad.mit.edu	37	21	46911162	46911162	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:46911162C>T	uc011afs.1	+	21	3357	c.3336C>T	c.(3334-3336)GTC>GTT	p.V1112V	COL18A1_uc002zhg.2_Silent_p.V697V|COL18A1_uc002zhi.2_Silent_p.V877V	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1112	Triple-helical region 4 (COL4).			V -> L (in Ref. 5; AAA51864).	cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGACGGAGTCGGGCAGCCGG	0.682		NaN											0	0	0	0.001984	0	5	87									
CHEK2	11200	broad.mit.edu	37	22	29091828	29091828	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29091828C>T	uc003adu.1	-	11	1201	c.1129G>A	c.(1129-1131)GAG>AAG	p.E377K	CHEK2_uc003ads.1_Missense_Mutation_p.E156K|CHEK2_uc010gvh.1_Missense_Mutation_p.E286K|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.E420K|CHEK2_uc003adv.1_Missense_Mutation_p.E348K|CHEK2_uc003adw.1_Missense_Mutation_p.E377K|CHEK2_uc003adx.1_Missense_Mutation_p.E156K|CHEK2_uc003ady.1_Missense_Mutation_p.E377K|CHEK2_uc003adz.1_Missense_Mutation_p.E181K	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	377	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AGAGAGGTCTCTCCCAAAATC	0.423		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.016522	0	22	74									
CHEK2	11200	broad.mit.edu	37	22	29092917	29092917	+	Nonsense_Mutation	SNP	G	G	T	rs121908703		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29092917G>T	uc003adu.1	-	10	1139	c.1067C>A	c.(1066-1068)TCA>TAA	p.S356*	CHEK2_uc003ads.1_Nonsense_Mutation_p.S135*|CHEK2_uc010gvh.1_Nonsense_Mutation_p.S265*|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Nonsense_Mutation_p.S399*|CHEK2_uc003adv.1_Intron|CHEK2_uc003adw.1_Nonsense_Mutation_p.S356*|CHEK2_uc003adx.1_Nonsense_Mutation_p.S135*|CHEK2_uc003ady.1_Nonsense_Mutation_p.S356*|CHEK2_uc003adz.1_Nonsense_Mutation_p.S160*	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	356	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TTCTTGAGATGACAGTAAAAC	0.378		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				1	0	1.36491e-13	0.016723	1.46545e-13	14	38									
CHEK2	11200	broad.mit.edu	37	22	29092969	29092969	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29092969G>A	uc003adu.1	-	10	1087	c.1015C>T	c.(1015-1017)CAT>TAT	p.H339Y	CHEK2_uc003ads.1_Missense_Mutation_p.H118Y|CHEK2_uc010gvh.1_Missense_Mutation_p.H248Y|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.H382Y|CHEK2_uc003adv.1_Intron|CHEK2_uc003adw.1_Missense_Mutation_p.H339Y|CHEK2_uc003adx.1_Missense_Mutation_p.H118Y|CHEK2_uc003ady.1_Missense_Mutation_p.H339Y|CHEK2_uc003adz.1_Missense_Mutation_p.H143Y	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	339	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCGTTTTCATGAAGGTACTAC	0.398		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.024245	0	12	33									
THOC5	8563	broad.mit.edu	37	22	29940524	29940524	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29940524G>C	uc003afr.2	-	4	500	c.165C>G	c.(163-165)TAC>TAG	p.Y55*	THOC5_uc003afs.2_Nonsense_Mutation_p.Y55*|THOC5_uc003aft.2_Nonsense_Mutation_p.Y55*|THOC5_uc003afu.2_Nonsense_Mutation_p.Y55*|THOC5_uc010gvo.2_5'UTR|THOC5_uc003afv.1_Nonsense_Mutation_p.Y55*|THOC5_uc003afw.1_5'Flank	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	55	Interaction with THOC7.|Interaction with CSF1R (By similarity).				intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						AGGTGTACTTGTATAACTCAT	0.542		NaN											0	0	0	0.027356	0	29	113									
GAL3ST1	9514	broad.mit.edu	37	22	30951254	30951254	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:30951254C>G	uc003aig.1	-	4	1098	c.958G>C	c.(958-960)GAG>CAG	p.E320Q	GAL3ST1_uc003aih.1_Missense_Mutation_p.E320Q|GAL3ST1_uc003aii.1_Missense_Mutation_p.E320Q|GAL3ST1_uc010gvz.1_Missense_Mutation_p.E320Q	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	320	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CCGAAGGCCTCCACCTTGCGC	0.711		NaN											0	0	0	0.00308	0	8	13									
MYH9	4627	broad.mit.edu	37	22	36695011	36695011	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:36695011G>A	uc003apg.2	-	24	3285	c.3054C>T	c.(3052-3054)CTC>CTT	p.L1018L		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1018	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGAGCTTGGCGAGGCTCTTAG	0.562		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.012319	0	22	57									
MFNG	4242	broad.mit.edu	37	22	37868558	37868558	+	Silent	SNP	G	G	A	rs11548403		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:37868558G>A	uc003ass.1	-	7	992	c.822C>T	c.(820-822)CTC>CTT	p.L274L	MFNG_uc011ani.1_Silent_p.L152L|MFNG_uc011anj.1_Silent_p.L260L|MFNG_uc003asr.1_RNA	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	274	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)					CACCGTAGCTGAGGGTGACCT	0.602		NaN									OREG0026538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	119									
KCNH8	131096	broad.mit.edu	37	3	19479720	19479720	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:19479720C>T	uc003cbk.1	+	8	1437	c.1242C>T	c.(1240-1242)GGC>GGT	p.G414G	KCNH8_uc011awe.1_Silent_p.G414G|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_Silent_p.G45G	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	414	Extracellular (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CCTTGGGGGGCCCGTCGATCC	0.488		NaN											0	0	0	0.01441	0	55	486									
GPD1L	23171	broad.mit.edu	37	3	32188164	32188164	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:32188164C>G	uc003cew.2	+	5	616	c.556C>G	c.(556-558)CCA>GCA	p.P186A		NM_015141	NP_055956	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	186					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity				0						TCTGCAGACTCCAAATTTTCG	0.433		NaN											0	0	0	0.01441	0	99	306									
SCN5A	6331	broad.mit.edu	37	3	38601887	38601887	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:38601887C>T	uc003cio.2	-	23	4190	c.3996G>A	c.(3994-3996)CCG>CCA	p.P1332P	SCN5A_uc003cin.2_Silent_p.P1331P|SCN5A_uc003cil.3_Silent_p.P1332P|SCN5A_uc010hhi.2_Silent_p.P1332P|SCN5A_uc010hhk.2_Silent_p.P1331P|SCN5A_uc011ayr.1_Silent_p.P1278P|SCN5A_uc010hhj.1_Silent_p.P942P	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1332			P -> L (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCATGATGGACGGGATGGCGC	0.582		NaN											0	0	0	0.012319	0	17	44									
SCN5A	6331	broad.mit.edu	37	3	38616877	38616877	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:38616877G>A	uc003cio.2	-	20	3771	c.3577C>T	c.(3577-3579)CGG>TGG	p.R1193W	SCN5A_uc003cin.2_Missense_Mutation_p.R1192W|SCN5A_uc003cil.3_Missense_Mutation_p.R1193W|SCN5A_uc010hhi.2_Missense_Mutation_p.R1193W|SCN5A_uc010hhk.2_Missense_Mutation_p.R1192W|SCN5A_uc011ayr.1_Missense_Mutation_p.R1139W|SCN5A_uc010hhj.1_Missense_Mutation_p.R803W	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1193					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.R1193W(1)		ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTGCGCAACCGCCACCAGACC	0.612		NaN											0	0	0	0.001984	0	7	7									
ZBTB47	92999	broad.mit.edu	37	3	42702987	42702987	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:42702987G>A	uc003clu.1	+	2	458	c.356G>A	c.(355-357)TGT>TAT	p.C119Y		NM_145166	NP_660149	Q9UFB7	ZBT47_HUMAN	zinc finger protein 651	119	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.216)		TGTGTGACATGTGGCAAAGCT	0.413		NaN											0	0	0	0.021022	0	31	49									
DHX30	22907	broad.mit.edu	37	3	47887699	47887699	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:47887699G>C	uc003cru.2	+	11	1563	c.1137G>C	c.(1135-1137)CAG>CAC	p.Q379H	DHX30_uc003crt.2_Missense_Mutation_p.Q340H	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	379						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TCCGGCTGCAGAGTGATGACA	0.542		NaN											0	0	0	0.01441	0	63	122									
MAP4	4134	broad.mit.edu	37	3	47956392	47956392	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:47956392C>G	uc003csb.2	-	8	2440	c.1914G>C	c.(1912-1914)CCG>CCC	p.P638P	MAP4_uc003csc.3_Silent_p.P638P|MAP4_uc011bbf.1_Silent_p.P615P|MAP4_uc003csf.3_Silent_p.P655P	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	638					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CCTCCTCGGCCGGCAAGCTGC	0.443		NaN											0	0	0	0.01441	0	71	135									
RNF123	63891	broad.mit.edu	37	3	49742439	49742439	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:49742439T>C	uc003cxh.2	+	23	2068	c.1982T>C	c.(1981-1983)GTT>GCT	p.V661A	RNF123_uc010hky.1_Missense_Mutation_p.V323A|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	661						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GCCCTGGCTGTTGGGGGGCCA	0.677		NaN											0	0	0	0.004482	0	7	5									
BAP1	8314	broad.mit.edu	37	3	52436887	52436887	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:52436887C>G	uc003ddx.2	-	15	2006	c.1891G>C	c.(1891-1893)GAG>CAG	p.E631Q	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_Intron	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	631	Potential.|Interaction with BRCA1.				monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.E631_A634del(1)|p.E631fs*3(1)		pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GCCAGCAGCTCCTGCCAAAAC	0.567		NaN	N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.006122	0	18	84									
SFMBT1	51460	broad.mit.edu	37	3	52939153	52939153	+	Nonstop_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:52939153C>G	uc003dgf.2	-	22	3169	c.2600G>C	c.(2599-2601)TGA>TCA	p.*867S	SFMBT1_uc010hmr.2_Nonstop_Mutation_p.*771S|SFMBT1_uc003dgg.2_Nonstop_Mutation_p.*867S|SFMBT1_uc003dgh.2_Nonstop_Mutation_p.*867S	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	867					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		TTGTCCTTCTCAGTTGGCAAA	0.453		NaN											0	0	0	0.01441	0	59	39									
EPHA6	285220	broad.mit.edu	37	3	96706766	96706766	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:96706766G>A	uc010how.1	+	3	1086	c.1043G>A	c.(1042-1044)GGA>GAA	p.G348E	EPHA6_uc003drp.1_Missense_Mutation_p.G348E	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	253	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GGAGCTGATGGAGATTGGCTG	0.428		NaN											0	0	0	0.01441	0	75	69									
MORC1	27136	broad.mit.edu	37	3	108782032	108782032	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:108782032C>T	uc003dxl.2	-	10	949	c.862G>A	c.(862-864)GAA>AAA	p.E288K	MORC1_uc011bhn.1_Missense_Mutation_p.E288K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	288	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTTTTAACTTCATCTTTAAAT	0.254		NaN											0	0	0	0.007413	0	16	109									
GSK3B	2932	broad.mit.edu	37	3	119562103	119562103	+	Silent	SNP	T	T	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:119562103T>A	uc003edo.2	-	10	2177	c.1194A>T	c.(1192-1194)TCA>TCT	p.S398S	GSK3B_uc003edn.2_Silent_p.S411S|GSK3B_uc003edm.2_Intron	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2	398					axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	CGTTCTTACCTGACGCTGCTG	0.318		NaN											0	0	0	0.008361	0	29	63									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.007413	0	7	20									
EEFSEC	60678	broad.mit.edu	37	3	127981020	127981020	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:127981020G>A	uc003eki.2	+	3	612	c.574G>A	c.(574-576)GAG>AAG	p.E192K	EEFSEC_uc003ekj.2_Missense_Mutation_p.E192K	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	192						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGGGGGACCAGAGGCCCCCGA	0.557		NaN											0	0	0	0.012319	0	20	162									
H1FX	8971	broad.mit.edu	37	3	129034635	129034635	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:129034635C>G	uc003elx.2	-	1	486	c.111G>C	c.(109-111)AAG>AAC	p.K37N	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	37					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCTTGCTATTCTTCCTCTTCT	0.622		NaN											0	0	0	0.004672	0	3	9									
ARMC8	25852	broad.mit.edu	37	3	137964026	137964026	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:137964026G>A	uc003esa.1	+	13	1459	c.1092_splice	c.e13+1	p.K364_splice	ARMC8_uc003erw.2_Missense_Mutation_p.V365M|ARMC8_uc003erx.2_Missense_Mutation_p.V365M|ARMC8_uc003ery.2_Missense_Mutation_p.V337M|ARMC8_uc003erz.2_Missense_Mutation_p.V337M|ARMC8_uc011bmf.1_Splice_Site_p.K347_splice|ARMC8_uc011bmg.1_Splice_Site_p.K311_splice|ARMC8_uc011bmh.1_Splice_Site_p.K305_splice|ARMC8_uc003esb.1_Splice_Site_p.K336_splice|ARMC8_uc003esc.1_Splice_Site_p.K136_splice	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2								binding				0						CCGGAAGAAGGTGAGTCTGGG	0.517		NaN											0	0	0	0.021523	0	23	74									
MED12L	116931	broad.mit.edu	37	3	151112625	151112625	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:151112625C>T	uc003eyp.2	+	37	5723	c.5685C>T	c.(5683-5685)CTC>CTT	p.L1895L	MED12L_uc011bnz.1_Silent_p.L1755L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1895	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCGACTTCTCAGGCAAGCCC	0.522		NaN											0	0	0	0.01441	0	50	62									
SMC4	10051	broad.mit.edu	37	3	160141236	160141236	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:160141236G>A	uc003fdh.2	+	14	2156	c.2043G>A	c.(2041-2043)ATG>ATA	p.M681I	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.M445I|SMC4_uc003fdi.2_Missense_Mutation_p.M656I|SMC4_uc003fdj.2_Missense_Mutation_p.M681I|SMC4_uc010hwd.2_Missense_Mutation_p.M681I|SMC4_uc003fdl.2_Missense_Mutation_p.M384I	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	681	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CGAAAAAGATGACCGAAATTC	0.269		NaN											0	0	0	0.01441	0	73	116									
MUC4	4585	broad.mit.edu	37	3	195518308	195518308	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:195518308C>G	uc011bto.1	-	2	603	c.143G>C	c.(142-144)GGC>GCC	p.G48A	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_5'Flank	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	48					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTTGTTGAGCCTGTTGAGGT	0.403		NaN											0	0	0	0.01441	0	49	258									
SENP5	205564	broad.mit.edu	37	3	196613274	196613274	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:196613274G>A	uc003fwz.3	+	2	1471	c.1222G>A	c.(1222-1224)GAT>AAT	p.D408N	SENP5_uc011bty.1_Missense_Mutation_p.D408N	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	408					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		TTCTGTCAGTGATGACAGAGT	0.423		NaN											0	0	0	0.00632	0	27	107									
WHSC1	7468	broad.mit.edu	37	4	1902964	1902964	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:1902964C>G	uc003gdz.3	+	2	759	c.583C>G	c.(583-585)CCT>GCT	p.P195A	WHSC1_uc003geb.3_Missense_Mutation_p.P195A|WHSC1_uc003gec.3_Missense_Mutation_p.P195A|WHSC1_uc003ged.3_Missense_Mutation_p.P195A|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.P195A|WHSC1_uc003gdy.1_Missense_Mutation_p.P195A|WHSC1_uc010icd.1_Missense_Mutation_p.P195A|WHSC1_uc003gea.1_Missense_Mutation_p.P195A|WHSC1_uc010ice.1_Missense_Mutation_p.P195A|WHSC1_uc003geg.1_Missense_Mutation_p.P195A|WHSC1_uc003geh.1_Missense_Mutation_p.P195A	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	195					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GATCTCAAGTCCTTCAGATAA	0.493		NaN	T	IGH@	MM								0	0	0	0.006214	0	8	62									
MXD4	10608	broad.mit.edu	37	4	2254191	2254191	+	Missense_Mutation	SNP	C	C	T	rs141784187	by1000genomes	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:2254191C>T	uc003geu.1	-	4	285	c.253G>A	c.(253-255)GAC>AAC	p.D85N		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	85	Helix-loop-helix motif.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						CGGGTGCTGTCGGGGCCCAGG	0.632		NaN											0	0	0	0.006214	0	9	40									
HTT	3064	broad.mit.edu	37	4	3237489	3237489	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:3237489C>T	uc011bvq.1	+	64	8920	c.8775C>T	c.(8773-8775)CTC>CTT	p.L2925L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2923					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GCCTGATGCTCACCTGCATGT	0.607		NaN											0	0	0	0.001984	0	7	22									
D4S234E	27065	broad.mit.edu	37	4	4419001	4419001	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:4419001G>A	uc011bvz.1	+	8	1678	c.397G>A	c.(397-399)GCG>ACG	p.A133T	D4S234E_uc011bwa.1_Missense_Mutation_p.A94T|D4S234E_uc003ghz.2_Missense_Mutation_p.A133T|D4S234E_uc003gia.2_Missense_Mutation_p.A133T|D4S234E_uc003gib.2_Missense_Mutation_p.A133T	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	133	Lumenal (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		GAGCTACTACGCGGAGCAAGA	0.567		NaN											0	0	0	0.007413	0	20	108									
TBC1D1	23216	broad.mit.edu	37	4	37903928	37903928	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:37903928C>T	uc003gtb.2	+	2	555	c.212C>T	c.(211-213)TCT>TTT	p.S71F	TBC1D1_uc011byd.1_Missense_Mutation_p.S71F|TBC1D1_uc010ifd.2_Missense_Mutation_p.S71F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	71						nucleus	Rab GTPase activator activity			ovary(1)	1						GTTTCACCCTCTGGACTGAGA	0.547		NaN											0	0	0	0.01892	0	24	128									
N4BP2	55728	broad.mit.edu	37	4	40123292	40123292	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:40123292C>T	uc003guy.3	+	9	3899	c.3561C>T	c.(3559-3561)AAC>AAT	p.N1187N	N4BP2_uc010ifq.2_Silent_p.N1107N|N4BP2_uc010ifr.2_Silent_p.N1107N	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1187						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GTATTAGTAACGCTGACTCAC	0.413		NaN											0	0	0	0.01441	0	61	101									
TMPRSS11B	132724	broad.mit.edu	37	4	69101948	69101948	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:69101948G>A	uc003hdw.3	-	3	297	c.161C>T	c.(160-162)TCT>TTT	p.S54F		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	54	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGTGACTCCAGAAATATGAAA	0.303		NaN											0	0	0	0.001984	0	6	27									
DCK	1633	broad.mit.edu	37	4	71888182	71888182	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:71888182C>T	uc003hfx.2	+	3	594	c.306C>T	c.(304-306)CTC>CTT	p.L102L	DCK_uc011cbb.1_Silent_p.L30L	NM_000788	NP_000779	P27707	DCK_HUMAN	deoxycytidine kinase	102					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	ATGCCTGTCTCAGTCGAATAA	0.403		NaN											0	0	0	0.016522	0	24	102									
WDFY3	23001	broad.mit.edu	37	4	85742700	85742700	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:85742700G>A	uc003hpd.2	-	11	1536	c.1128C>T	c.(1126-1128)CAC>CAT	p.H376H	WDFY3_uc003hpf.2_Silent_p.H376H	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	376						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding	p.H376Y(1)		ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCTCACACTGTGACCTAGAA	0.338		NaN											0	0	0	0.01892	0	24	101									
IBSP	3381	broad.mit.edu	37	4	88732815	88732815	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:88732815A>C	uc003hqx.3	+	7	805	c.707A>C	c.(706-708)GAA>GCA	p.E236A		NM_004967	NP_004958	P21815	SIAL_HUMAN	integrin-binding sialoprotein precursor	236					biomineral tissue development|cell adhesion|ossification						0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		GGTGGGTTTGAACCTACAACC	0.527		NaN											0	0	0	0.006214	0	9	41									
ADH6	130	broad.mit.edu	37	4	100130048	100130048	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:100130048C>G	uc003hup.3	-	6	699	c.605G>C	c.(604-606)GGA>GCA	p.G202A	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.G202A|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Missense_Mutation_p.G202A	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	202	NAD (By similarity).				ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GCCGACTCCTCCCAGGCCAAA	0.458		NaN											0	0	0	0.01441	0	53	253									
TET2	54790	broad.mit.edu	37	4	106155204	106155204	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:106155204G>A	uc003hxk.2	+	3	491	c.105G>A	c.(103-105)CAG>CAA	p.Q35Q	TET2_uc011cez.1_Silent_p.Q56Q|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.Q35Q|TET2_uc003hxi.1_Silent_p.Q35Q	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	35					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CAAAGCTCCAGAATGGAAGCC	0.463		NaN	Mis N|F		MDS								0	0	0	0.020292	0	15	43									
TIGD4	201798	broad.mit.edu	37	4	153690793	153690793	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:153690793T>C	uc003imy.2	-	2	2146	c.1364A>G	c.(1363-1365)GAT>GGT	p.D455G		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	455					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					ATCCTCTTCATCAGAAGTGTA	0.398		NaN											0	0	0	0.007413	0	19	52									
WDR17	116966	broad.mit.edu	37	4	177058703	177058703	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:177058703C>T	uc003iuj.2	+	10	1528	c.1372C>T	c.(1372-1374)CGA>TGA	p.R458*	WDR17_uc003iuk.2_Nonsense_Mutation_p.R434*|WDR17_uc003ium.3_Nonsense_Mutation_p.R434*|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	458	WD 7.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GGGAACTTCCCGAAATGGTGC	0.274		NaN											0	0	0	0.006122	0	13	42									
NEIL3	55247	broad.mit.edu	37	4	178256885	178256885	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:178256885G>C	uc003iut.2	+	3	439	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	NEIL3_uc010irs.2_Missense_Mutation_p.E11Q	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	108					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		TAATCCACTTGAGTATAAATA	0.328		NaN						BER_DNA_glycosylases					0	0	0	0.00632	0	28	51									
ODZ3	55714	broad.mit.edu	37	4	183603124	183603124	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:183603124C>T	uc003ivd.1	+	10	2029	c.1992C>T	c.(1990-1992)TCC>TCT	p.S664S	ODZ3_uc003ive.1_Silent_p.S70S	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	664	EGF-like 5.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AAAGTGGCTCCTGCACGTGTG	0.488		NaN											0	0	0	0.007413	0	18	49									
DNAH5	1767	broad.mit.edu	37	5	13885116	13885116	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:13885116G>A	uc003jfd.2	-	19	3007	c.2965C>T	c.(2965-2967)CAC>TAC	p.H989Y		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	989	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTAATTGTGTGAGAGGAATGA	0.368		NaN							Kartagener_syndrome				0	0	0	0.008361	0	31	132									
NPR3	4883	broad.mit.edu	37	5	32712404	32712404	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:32712404C>G	uc003jhv.2	+	1	740	c.522C>G	c.(520-522)CTC>CTG	p.L174L	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Silent_p.L174L	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	174	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	ACTCGCACCTCACGCGCGTGG	0.682		NaN											0	0	0	0.008291	0	10	112									
IL7R	3575	broad.mit.edu	37	5	35867471	35867471	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:35867471G>C	uc003jjs.2	+	3	374	c.285G>C	c.(283-285)GAG>GAC	p.E95D	IL7R_uc011coo.1_Missense_Mutation_p.E95D|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	95	Extracellular (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ATTTCATCGAGACAAAGAAAT	0.383		NaN											0	0	0	0.024334	0	26	216									
OXCT1	5019	broad.mit.edu	37	5	41840601	41840601	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:41840601C>T	uc003jmn.2	-	7	1015	c.684G>A	c.(682-684)AGG>AGA	p.R228R		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	228					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	AGTTGAAATTCCTTGCACTTT	0.373		NaN											0	0	0	0.025465	0	34	177									
CENPK	64105	broad.mit.edu	37	5	64814433	64814433	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:64814433G>A	uc003jts.2	-	11	891	c.679C>T	c.(679-681)CCA>TCA	p.P227S	CENPK_uc003jtt.2_Missense_Mutation_p.P197S|CENPK_uc003jtu.2_Missense_Mutation_p.P227S	NM_022145	NP_071428	Q9BS16	CENPK_HUMAN	SoxLZ/Sox6 leucine zipper binding protein	227					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		GGATCATGTGGAACATCAAAT	0.333		NaN											0	0	0	0.016723	0	13	57									
ERBB2IP	55914	broad.mit.edu	37	5	65349677	65349677	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:65349677C>T	uc003juk.1	+	21	2839	c.2531C>T	c.(2530-2532)TCT>TTT	p.S844F	ERBB2IP_uc003jui.1_Missense_Mutation_p.S844F|ERBB2IP_uc003juj.1_Missense_Mutation_p.S844F|ERBB2IP_uc011cqx.1_Missense_Mutation_p.S844F|ERBB2IP_uc011cqy.1_Missense_Mutation_p.S844F|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.S840F|ERBB2IP_uc003jul.1_Missense_Mutation_p.S840F	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	844					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGTGATTGTTCTGTTGACTTA	0.393		NaN											0	0	0	0.020292	0	15	36									
ERBB2IP	55914	broad.mit.edu	37	5	65349994	65349994	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:65349994C>G	uc003juk.1	+	21	3156	c.2848C>G	c.(2848-2850)CAT>GAT	p.H950D	ERBB2IP_uc003jui.1_Missense_Mutation_p.H950D|ERBB2IP_uc003juj.1_Missense_Mutation_p.H950D|ERBB2IP_uc011cqx.1_Missense_Mutation_p.H950D|ERBB2IP_uc011cqy.1_Missense_Mutation_p.H950D|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.H946D|ERBB2IP_uc003jul.1_Missense_Mutation_p.H946D	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	950					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGATTCAAATCATAATCCCGA	0.383		NaN											0	0	0	0.020292	0	13	63									
HSD17B4	3295	broad.mit.edu	37	5	118788291	118788291	+	Missense_Mutation	SNP	C	C	G	rs143278360		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:118788291C>G	uc003ksj.2	+	1	144	c.21C>G	c.(19-21)TTC>TTG	p.F7L	HSD17B4_uc011cwg.1_5'UTR|HSD17B4_uc011cwh.1_Missense_Mutation_p.F7L|HSD17B4_uc011cwi.1_5'UTR|HSD17B4_uc003ksk.3_5'UTR	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	7	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	CGCTGAGGTTCGACGGGCGGG	0.667		NaN											0	0	0	0.006122	0	15	42									
PCDHA7	56141	broad.mit.edu	37	5	140215764	140215764	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:140215764C>T	uc003lhq.2	+	1	1796	c.1796C>T	c.(1795-1797)GCT>GTT	p.A599V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A599V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	599	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTTGACGCTGACTCAGGC	0.657		NaN											0	0	0	0.010504	0	21	79									
DCTN4	51164	broad.mit.edu	37	5	150097924	150097924	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:150097924G>C	uc003lsv.2	-	11	1087	c.985C>G	c.(985-987)CTT>GTT	p.L329V	DCTN4_uc003lsu.2_Missense_Mutation_p.L272V|DCTN4_uc010jhi.2_Missense_Mutation_p.L336V	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	329						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGATTTGTAAGAGTCAGGAGG	0.468		NaN											0	0	0	0.027356	0	26	19									
ODZ2	57451	broad.mit.edu	37	5	167517748	167517748	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:167517748T>A	uc010jjd.2	+	8	1685	c.1685T>A	c.(1684-1686)ATG>AAG	p.M562K	ODZ2_uc003lzq.2_Missense_Mutation_p.M441K|ODZ2_uc003lzr.3_Missense_Mutation_p.M330K|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GACAAAGAGATGGTTTCCTTC	0.483		NaN											0	0	0	0.01441	0	41	147									
ODZ2	57451	broad.mit.edu	37	5	167631486	167631486	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:167631486C>G	uc010jjd.2	+	19	3657	c.3657C>G	c.(3655-3657)TGC>TGG	p.C1219W	ODZ2_uc003lzr.3_Missense_Mutation_p.C996W|ODZ2_uc003lzt.3_Missense_Mutation_p.C592W|ODZ2_uc010jje.2_Missense_Mutation_p.C490W	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GTCCCAGCTGCAACGGCCTTG	0.577		NaN											0	0	0	0.013537	0	11	50									
DOCK2	1794	broad.mit.edu	37	5	169122827	169122827	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:169122827C>G	uc003maf.2	+	10	944	c.864C>G	c.(862-864)CTC>CTG	p.L288L	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	288					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACAAAGACCTCAACAGGGATA	0.433		NaN											0	0	0	0.008871	0	18	83									
PRPF4B	8899	broad.mit.edu	37	6	4056655	4056655	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:4056655G>C	uc003mvv.2	+	12	2658	c.2567G>C	c.(2566-2568)CGT>CCT	p.R856P	PRPF4B_uc003mvw.2_RNA|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	856	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				AGATTTTATCGTGCTCCTGAA	0.383		NaN											0	0	0	0.012213	0	30	123									
NEDD9	4739	broad.mit.edu	37	6	11185604	11185604	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:11185604G>A	uc003mzv.2	-	7	2463	c.2296C>T	c.(2296-2298)CAG>TAG	p.Q766*	NEDD9_uc010joz.2_Nonsense_Mutation_p.Q766*|NEDD9_uc003mzw.3_Nonsense_Mutation_p.Q620*	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	766					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCAGTCACCTGCCGTGTCAGC	0.557		NaN											0	0	0	0.012213	0	30	329									
DTNBP1	84062	broad.mit.edu	37	6	15663055	15663055	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:15663055A>T	uc003nbm.2	-	1	217	c.46T>A	c.(46-48)TTC>ATC	p.F16I	DTNBP1_uc003nbl.2_5'UTR|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA|DTNBP1_uc003nbp.2_Missense_Mutation_p.F16I|DTNBP1_uc010jph.2_5'UTR	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	16					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			CCGGAGGTGAAATCCTGCTGC	0.716		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.024334	0	25	166									
HIST1H3E	8353	broad.mit.edu	37	6	26225674	26225674	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:26225674G>A	uc003nhb.2	+	2	652	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST1H3E_uc003nhc.3_Missense_Mutation_p.E98K	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GGAGGCCTGCGAGGCCTACTT	0.592		NaN									OREG0017240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	71	88									
HIST1H1D	3007	broad.mit.edu	37	6	26234919	26234919	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:26234919G>C	uc003nhd.2	-	1	298	c.243C>G	c.(241-243)ATC>ATG	p.I81M		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	81	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GGCCAAGCTTGATACGGCTGT	0.542		NaN											0	0	0	0.01441	0	64	134									
SCAND3	114821	broad.mit.edu	37	6	28540437	28540437	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:28540437C>T	uc003nlo.2	-	4	3847	c.3229G>A	c.(3229-3231)GAA>AAA	p.E1077K		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1077					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						actaagagttcatttcgtatt	0		NaN											0	0	0	0.008361	0	30	104									
HLA-A	3105	broad.mit.edu	37	6	29913231	29913231	+	Nonstop_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:29913231G>C	uc003nol.2	+	8	1097	c.1097G>C	c.(1096-1098)TGA>TCA	p.*366S	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc003non.2_Nonstop_Mutation_p.*372S|HLA-A_uc003noo.2_Missense_Mutation_p.E367Q|HLA-A_uc010jrr.2_Nonstop_Mutation_p.*300S|HLA-A_uc003nom.2_Missense_Mutation_p.E244Q|HLA-A_uc011dmc.1_Nonstop_Mutation_p.*245S|HLA-A_uc011dmd.1_3'UTR	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	366					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTATAGTGTGAGACAGCTGC	0.448		NaN							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			0	0	0	0.012319	0	19	65									
BAT1	7919	broad.mit.edu	37	6	31500659	31500659	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:31500659C>T	uc003ntt.2	-	7	1396	c.765G>A	c.(763-765)ACG>ACA	p.T255T	BAT1_uc003ntq.2_5'Flank|BAT1_uc003ntr.2_Silent_p.T62T|BAT1_uc003nts.2_Silent_p.T255T|BAT1_uc011dnn.1_Silent_p.T177T|BAT1_uc003ntu.2_Silent_p.T255T|BAT1_uc003ntv.2_Silent_p.T255T	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	255					intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						GCGTCAACTTCGTCTCATCAT	0.388		NaN											0	0	0	0.007413	0	18	51									
BAT1	7919	broad.mit.edu	37	6	31503186	31503186	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:31503186C>G	uc003ntt.2	-	6	1324	c.693G>C	c.(691-693)TTG>TTC	p.L231F	BAT1_uc003ntr.2_5'Flank|BAT1_uc003nts.2_Missense_Mutation_p.L231F|BAT1_uc011dnn.1_Missense_Mutation_p.L153F|BAT1_uc003ntu.2_Missense_Mutation_p.L231F|BAT1_uc003ntv.2_Missense_Mutation_p.L231F|BAT1_uc003ntw.2_Missense_Mutation_p.L231F|BAT1_uc003ntx.2_Missense_Mutation_p.L231F|BAT1_uc011dno.1_Missense_Mutation_p.L184F|BAT1_uc011dnp.1_Missense_Mutation_p.L153F	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	231	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						TCTCTTTGCTCAAGGTAGCAC	0.343		NaN											0	0	0	0.027356	0	24	110									
TNXB	7148	broad.mit.edu	37	6	32053791	32053791	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:32053791C>T	uc003nzl.2	-	7	3086	c.2884G>A	c.(2884-2886)GAG>AAG	p.E962K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1049	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCCCAGCTCCTGGGGGCGC	0.662		NaN											0	0	0	0.013537	0	13	18									
PFDN6	10471	broad.mit.edu	37	6	33258524	33258524	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:33258524G>C	uc003odt.1	+	5	407	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	WDR46_uc003ods.2_5'Flank|WDR46_uc011dra.1_5'Flank|WDR46_uc010juo.1_5'Flank|PFDN6_uc010jup.1_Missense_Mutation_p.E98Q	NM_014260	NP_055075	O15212	PFD6_HUMAN	HLA class II region expressed gene KE2	98					'de novo' posttranslational protein folding|chaperone-mediated protein complex assembly	prefoldin complex	chaperone binding|unfolded protein binding				0						TCGGGATCTTGAGCGGCAGTC	0.562		NaN											0	0	0	0.00308	0	8	27									
HMGCLL1	54511	broad.mit.edu	37	6	55406532	55406532	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:55406532G>T	uc003pcn.2	-	4	541	c.382C>A	c.(382-384)CCA>ACA	p.P128T	HMGCLL1_uc003pco.2_Missense_Mutation_p.P98T|HMGCLL1_uc010jzx.2_5'UTR|HMGCLL1_uc011dxc.1_Missense_Mutation_p.P98T|HMGCLL1_uc011dxd.1_Missense_Mutation_p.P98T|HMGCLL1_uc011dxe.1_Missense_Mutation_p.P98T|HMGCLL1_uc003pcp.2_Missense_Mutation_p.P98T	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	128							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATACCTGTGGTACCCATCTG	0.308		NaN											1	0	1.75199e-13	0.007291	1.87685e-13	28	125									
NT5E	4907	broad.mit.edu	37	6	86200279	86200279	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:86200279G>A	uc003pko.3	+	7	1820	c.1264G>A	c.(1264-1266)GAC>AAC	p.D422N	NT5E_uc010kbr.2_Intron	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	422					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	AGGCACATTTGACCTAGTCCA	0.517		NaN											0	0	0	0.014323	0	23	59									
ORC3L	23595	broad.mit.edu	37	6	88321837	88321837	+	Silent	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:88321837C>G	uc003pmh.2	+	8	788	c.744C>G	c.(742-744)CTC>CTG	p.L248L	ORC3L_uc011dzl.1_Silent_p.L248L|ORC3L_uc011dzm.1_Silent_p.L248L|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Silent_p.L248L|ORC3L_uc003pmi.2_Silent_p.L248L|ORC3L_uc011dzo.1_Silent_p.L105L|ORC3L_uc011dzp.1_Silent_p.L105L	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	248					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		CACTAATACTCATTTTTGGAA	0.328		NaN											0	0	0	0.012319	0	20	58									
UBE2J1	51465	broad.mit.edu	37	6	90045107	90045107	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:90045107C>G	uc010kcb.2	-	7	645	c.472G>C	c.(472-474)GAT>CAT	p.D158H	UBE2J1_uc003pnc.2_Missense_Mutation_p.D158H	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	158	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		AACAGGACATCCTTCATGGCA	0.358		NaN											0	0	0	0.012319	0	21	54									
PRDM1	639	broad.mit.edu	37	6	106552838	106552838	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:106552838G>A	uc003prd.2	+	5	1037	c.803G>A	c.(802-804)CGT>CAT	p.R268H	PRDM1_uc003pre.2_Missense_Mutation_p.R134H	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	268					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GACCTCTACCGTTCTAACATT	0.478		NaN	D|N|Mis|F|S		DLBCL								0	0	0	0.01441	0	83	734									
PDSS2	57107	broad.mit.edu	37	6	107780282	107780282	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:107780282G>T	uc003prt.2	-	1	498	c.208C>A	c.(208-210)CGC>AGC	p.R70S	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Missense_Mutation_p.R70S|PDSS2_uc003pru.2_Missense_Mutation_p.R70S|PDSS2_uc003prv.2_Missense_Mutation_p.R70S	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	70					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		AGCAGGCAGCGAAGGCTCATG	0.622		NaN									OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.86212e-05	0.008291	3.93576e-05	10	56									
PDSS2	57107	broad.mit.edu	37	6	107780434	107780434	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:107780434G>A	uc003prt.2	-	1	346	c.56C>T	c.(55-57)TCC>TTC	p.S19F	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Missense_Mutation_p.S19F|PDSS2_uc003pru.2_Missense_Mutation_p.S19F|PDSS2_uc003prv.2_Missense_Mutation_p.S19F	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	19					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		GCGACGCGGGGAACCCGAGGC	0.617		NaN									OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	17	115									
REV3L	5980	broad.mit.edu	37	6	111628632	111628632	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:111628632G>A	uc003puy.3	-	31	9507	c.9184C>T	c.(9184-9186)CAG>TAG	p.Q3062*	REV3L_uc003pux.3_Nonsense_Mutation_p.Q2984*|REV3L_uc003puz.3_Nonsense_Mutation_p.Q2984*|REV3L_uc003puw.3_Nonsense_Mutation_p.Q129*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	3062					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCAACATGCTGAGGTTGGCTC	0.458		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.012213	0	28	98									
RWDD1	51389	broad.mit.edu	37	6	116914146	116914146	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:116914146G>C	uc003pxd.2	+	7	777	c.614G>C	c.(613-615)GGA>GCA	p.G205A	RWDD1_uc003pxb.2_Missense_Mutation_p.G109A|RWDD1_uc003pxc.2_Missense_Mutation_p.G109A	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	205							protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TTTGCAGCTGGAAACAACGTG	0.393		NaN											0	0	0	0.004482	0	7	44									
PTPRK	5796	broad.mit.edu	37	6	128291416	128291416	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:128291416G>A	uc003qbk.2	-	30	4643	c.4276C>T	c.(4276-4278)CGT>TGT	p.R1426C	PTPRK_uc003qbj.2_Missense_Mutation_p.R1427C|PTPRK_uc010kfc.2_Missense_Mutation_p.R1433C|PTPRK_uc011ebu.1_Missense_Mutation_p.R1449C	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1426	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TAGCAGAAACGGTATTGCTCC	0.373		NaN											0	0	0	0.008871	0	19	59									
PERP	64065	broad.mit.edu	37	6	138413346	138413346	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:138413346G>C	uc003qht.2	-	3	598	c.415C>G	c.(415-417)CTT>GTT	p.L139V		NM_022121	NP_071404	Q96FX8	PERP_HUMAN	PERP, TP53 apoptosis effector	139					apoptosis|cell adhesion	desmosome|Golgi apparatus|integral to membrane|nucleus					0	Breast(32;0.0799)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000878)|OV - Ovarian serous cystadenocarcinoma(155;0.000997)		TTGGCATGAAGGGTGAAGGTC	0.488		NaN											0	0	0	0.027356	0	26	102									
C7orf27	221927	broad.mit.edu	37	7	2583404	2583404	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:2583404G>A	uc003smi.2	-	5	665	c.623C>T	c.(622-624)TCC>TTC	p.S208F	C7orf27_uc003smh.3_5'Flank|C7orf27_uc003smj.1_Missense_Mutation_p.S208F	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	208					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		GGTGGCCGCGGAGCACAAGGA	0.677		NaN											0	0	0	0.01441	0	44	149									
TNRC18	84629	broad.mit.edu	37	7	5353241	5353241	+	Silent	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:5353241G>C	uc003soi.3	-	27	7630	c.7281C>G	c.(7279-7281)CTC>CTG	p.L2427L		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2427	Pro-rich.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCATGGTGATGAGGGGTGCTG	0.721		NaN											0	0	0	0.024245	0	13	13									
RPA3	6119	broad.mit.edu	37	7	7676707	7676707	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:7676707C>G	uc003sri.2	-	8	1462	c.290G>C	c.(289-291)GGA>GCA	p.G97A	RPA3_uc003srh.2_Missense_Mutation_p.G58A	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	97					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		ATTGTAAAGTCCAAGATCTGA	0.303		NaN						Direct_reversal_of_damage|NER					0	0	0	0.00632	0	29	211									
DNAH11	8701	broad.mit.edu	37	7	21599258	21599258	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:21599258G>T	uc003svc.2	+	4	761	c.730G>T	c.(730-732)GAA>TAA	p.E244*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	244	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCATGCAATTGAATCTGTGGT	0.338		NaN							Kartagener_syndrome				1	0	6.32553e-13	0.024334	6.7463e-13	25	34									
CCDC129	223075	broad.mit.edu	37	7	31611746	31611746	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:31611746C>T	uc003tcj.1	+	6	1332	c.339C>T	c.(337-339)ATC>ATT	p.I113I	CCDC129_uc011kad.1_Silent_p.I123I|CCDC129_uc003tci.1_Silent_p.I112I|CCDC129_uc011kae.1_Silent_p.I139I|CCDC129_uc003tck.1_Silent_p.I21I	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	113											0						AAACTCCCATCCTATCCAGAG	0.398		NaN											0	0	0	0.016723	0	10	82									
BBS9	27241	broad.mit.edu	37	7	33545228	33545228	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:33545228C>G	uc003tdn.1	+	20	2782	c.2269C>G	c.(2269-2271)CTG>GTG	p.L757V	BBS9_uc003tdo.1_Missense_Mutation_p.L722V|BBS9_uc003tdp.1_Missense_Mutation_p.L752V|BBS9_uc003tdq.1_Missense_Mutation_p.L717V|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.L281V|BBS9_uc003tds.1_Missense_Mutation_p.L180V|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	757					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			AGCGGCATTTCTGCCGCTACA	0.488		NaN							Bardet-Biedl_syndrome				0	0	0	0.004007	0	17	136									
GLI3	2737	broad.mit.edu	37	7	42005585	42005585	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:42005585C>T	uc011kbh.1	-	15	3177	c.3086G>A	c.(3085-3087)AGC>AAC	p.S1029N	GLI3_uc011kbg.1_Missense_Mutation_p.S970N	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1029					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GGGGTTGCAGCTGCTGAGGCT	0.711		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.021553	0	5	25									
GLI3	2737	broad.mit.edu	37	7	42005604	42005604	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:42005604G>A	uc011kbh.1	-	15	3158	c.3067C>T	c.(3067-3069)CGC>TGC	p.R1023C	GLI3_uc011kbg.1_Missense_Mutation_p.R964C	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1023					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGCTGAAGCGCGGCACACGA	0.731		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.014758	0	4	22									
ABCA13	154664	broad.mit.edu	37	7	48266924	48266924	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:48266924C>G	uc003toq.2	+	6	559	c.534C>G	c.(532-534)ATC>ATG	p.I178M	ABCA13_uc003top.2_Missense_Mutation_p.I178M|ABCA13_uc010kyr.2_Translation_Start_Site	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	178					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGCCTCATATCTGGGATTTTC	0.428		NaN											0	0	0	0.013726	0	32	135									
ABCA13	154664	broad.mit.edu	37	7	48349571	48349571	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:48349571C>T	uc003toq.2	+	24	9374	c.9349C>T	c.(9349-9351)CTG>TTG	p.L3117L	ABCA13_uc010kys.1_Silent_p.L191L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3117					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CACCGTAGCTCTGTCTGGAAA	0.502		NaN											0	0	0	0.010504	0	21	105									
AUTS2	26053	broad.mit.edu	37	7	70249966	70249966	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:70249966C>G	uc003tvw.3	+	16	2928	c.2185C>G	c.(2185-2187)CCT>GCT	p.P729A	AUTS2_uc003tvx.3_Missense_Mutation_p.P705A|AUTS2_uc011keg.1_Missense_Mutation_p.P181A	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	729										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TGGGCCACCTCCTCATCACAG	0.507		NaN											0	0	0	0.00499	0	14	62									
GTF2IRD1	9569	broad.mit.edu	37	7	73933956	73933956	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:73933956C>G	uc003uaq.2	+	6	1216	c.823C>G	c.(823-825)CCT>GCT	p.P275A	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.P307A|GTF2IRD1_uc003uap.2_Missense_Mutation_p.P275A|GTF2IRD1_uc003uar.1_Missense_Mutation_p.P275A	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	275						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						GCAGGAAGCACCTTCCTGCCC	0.657		NaN											0	0	0	0.013537	0	13	55									
ABCB4	5244	broad.mit.edu	37	7	87072646	87072646	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:87072646C>T	uc003uiv.1	-	12	1421	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	ABCB4_uc003uiw.1_Missense_Mutation_p.D449N|ABCB4_uc003uix.1_Missense_Mutation_p.D449N	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	449	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GTGCCCTCATCAGGGTCATAG	0.507		NaN											0	0	0	0.01441	0	83	268									
STAG3	10734	broad.mit.edu	37	7	99783835	99783835	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:99783835G>C	uc003utx.1	+	5	504	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	STAG3_uc010lgs.1_5'UTR|STAG3_uc011kjk.1_Intron	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	117					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTTGGTAGATGAGTGGCTGGA	0.284		NaN											0	0	0	0.017118	0	30	197									
CDHR3	222256	broad.mit.edu	37	7	105672957	105672957	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:105672957C>T	uc003vdl.3	+	19	2580	c.2472C>T	c.(2470-2472)GTC>GTT	p.V824V	CDHR3_uc003vdk.2_3'UTR|CDHR3_uc003vdm.3_Silent_p.V811V|CDHR3_uc011klt.1_Silent_p.V736V|CDHR3_uc003vdn.2_3'UTR	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	824	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CACGCAGAGTCACTGCTGGGG	0.532		NaN											0	0	0	0.006122	0	16	22									
SLC26A4	5172	broad.mit.edu	37	7	107315425	107315425	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:107315425G>A	uc003vep.2	+	6	860	c.636G>A	c.(634-636)GTG>GTA	p.V212V		NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	212	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						GATTCATAGTGAGGTACTTGG	0.413		NaN							Pendred_syndrome				0	0	0	0.01441	0	57	181									
PPP1R3A	5506	broad.mit.edu	37	7	113518587	113518587	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:113518587C>T	uc010ljy.1	-	4	2591	c.2560G>A	c.(2560-2562)GAA>AAA	p.E854K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	854					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TTTTGATATTCTGTAATGACC	0.378		NaN											0	0	0	0.025465	0	38	150									
ZNF777	27153	broad.mit.edu	37	7	149152502	149152502	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:149152502C>T	uc003wfv.2	-	2	775	c.612G>A	c.(610-612)ATG>ATA	p.M204I		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCAGTAGCCTCATGGCCTGGG	0.602		NaN											0	0	0	0.024334	0	27	102									
PTPRN2	5799	broad.mit.edu	37	7	157926662	157926662	+	Silent	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:157926662G>C	uc003wno.2	-	9	1384	c.1263C>G	c.(1261-1263)CTC>CTG	p.L421L	PTPRN2_uc003wnp.2_Silent_p.L404L|PTPRN2_uc003wnq.2_Silent_p.L421L|PTPRN2_uc003wnr.2_Silent_p.L383L|PTPRN2_uc011kwa.1_Silent_p.L444L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	421	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TCTCCATGTCGAGGGGCCTTG	0.592		NaN											0	0	0	0.010818	0	31	81									
WDR60	55112	broad.mit.edu	37	7	158718985	158718985	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:158718985C>G	uc003woe.3	+	18	2523	c.2365C>G	c.(2365-2367)CAA>GAA	p.Q789E	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Missense_Mutation_p.Q421E	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	789	WD 2.									ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		CTTTTCTACTCAAGAAGGTAC	0.393		NaN											0	0	0	0.004672	0	3	18									
MYOM2	9172	broad.mit.edu	37	8	2057272	2057272	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:2057272G>A	uc003wpx.3	+	25	3268	c.3130G>A	c.(3130-3132)GAT>AAT	p.D1044N	MYOM2_uc011kwi.1_Missense_Mutation_p.D469N	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1044					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTTATCACCAGATGCCAGCTA	0.463		NaN											0	0	0	0.021022	0	37	45									
SPAG11B	10407	broad.mit.edu	37	8	7308402	7308402	+	Nonstop_Mutation	SNP	T	T	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:7308402T>C	uc003wrk.2	-	4	478	c.311A>G	c.(310-312)TAG>TGG	p.*104W	SPAG11B_uc003wrg.1_Missense_Mutation_p.R79G|SPAG11B_uc003wrh.1_Intron|SPAG11B_uc003wri.2_Nonstop_Mutation_p.*51W|SPAG11B_uc003wrj.2_Missense_Mutation_p.R26G|SPAG11B_uc003wrl.2_Missense_Mutation_p.R79G	NM_016512	NP_057596	Q08648	SG11B_HUMAN	sperm associated antigen 11B isoform A	104					spermatogenesis	extracellular region					0				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		ATGGTATTTCTAATTCCCGGT	0.458		NaN											0	0	0	0.014323	0	22	64									
SGK223	157285	broad.mit.edu	37	8	8197120	8197120	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:8197120C>G	uc003wsh.3	-	3	2188	c.2188G>C	c.(2188-2190)GAT>CAT	p.D730H		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	730							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TTTTCCAAATCAGAGCTGCTC	0.498		NaN											0	0	0	0.015359	0	32	56									
PRKDC	5591	broad.mit.edu	37	8	48805803	48805803	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:48805803G>A	uc003xqi.2	-	32	3801	c.3744C>T	c.(3742-3744)TTC>TTT	p.F1248F	PRKDC_uc003xqj.2_Silent_p.F1248F|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1248					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCTGCAGGCTGAATGGCCCCC	0.617		NaN						NHEJ					0	0	0	0.014758	0	5	26									
PXDNL	137902	broad.mit.edu	37	8	52339252	52339252	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:52339252G>A	uc003xqu.3	-	13	1693	c.1592C>T	c.(1591-1593)TCA>TTA	p.S531L		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	531	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGCATGACATGAAATGTTTAT	0.358		NaN											0	0	0	0.021553	0	5	31									
CLVS1	157807	broad.mit.edu	37	8	62371083	62371083	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:62371083C>T	uc003xuh.2	+	5	1283	c.959C>T	c.(958-960)TCA>TTA	p.S320L	CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Intron	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	320					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						AGAGAATGCTCACCCAAGCTG	0.443		NaN											0	0	0	0.004007	0	14	32									
TRIM55	84675	broad.mit.edu	37	8	67047319	67047319	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:67047319C>T	uc003xvv.2	+	3	662	c.436C>T	c.(436-438)CTG>TTG	p.L146L	TRIM55_uc003xvu.2_Silent_p.L146L|TRIM55_uc003xvw.2_Silent_p.L146L|TRIM55_uc003xvx.2_Silent_p.L146L	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	146						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CACCTGCTCTCTGTGCAAGGT	0.547		NaN											0	0	0	0.00499	0	17	126									
NCOA2	10499	broad.mit.edu	37	8	71053436	71053436	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:71053436G>C	uc003xyn.1	-	14	3173	c.3011C>G	c.(3010-3012)TCT>TGT	p.S1004C	NCOA2_uc011lfb.1_Missense_Mutation_p.S92C	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1004					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CATGACCTGAGACTGAAGCGT	0.498		NaN	T	RUNXBP2	AML								0	0	0	0.021553	0	6	55									
ZFHX4	79776	broad.mit.edu	37	8	77766597	77766597	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:77766597G>A	uc003yav.2	+	10	7692	c.7305G>A	c.(7303-7305)ACG>ACA	p.T2435T	ZFHX4_uc003yau.1_Silent_p.T2480T|ZFHX4_uc003yaw.1_Silent_p.T2435T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2435						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTCCATGACGTCTCTCCAGA	0.458		NaN								HNSCC(33;0.089)			0	0	0	0.01441	0	117	22									
CSMD3	114788	broad.mit.edu	37	8	113318315	113318315	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:113318315C>A	uc003ynu.2	-	51	8151	c.7992G>T	c.(7990-7992)TTG>TTT	p.L2664F	CSMD3_uc003yns.2_Missense_Mutation_p.L1866F|CSMD3_uc003ynt.2_Missense_Mutation_p.L2624F|CSMD3_uc011lhx.1_Missense_Mutation_p.L2560F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2664	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTTGGATGACAATCGATATC	0.418		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	5.8336e-16	0.015359	6.36273e-16	33	106									
TTC39B	158219	broad.mit.edu	37	9	15188001	15188001	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:15188001C>G	uc003zlr.1	-	14	1286	c.1165G>C	c.(1165-1167)GAT>CAT	p.D389H	TTC39B_uc003zlq.1_Missense_Mutation_p.D358H|TTC39B_uc011lmp.1_Missense_Mutation_p.D290H|TTC39B_uc010mie.1_Missense_Mutation_p.D387H|TTC39B_uc011lmq.1_Missense_Mutation_p.D376H|TTC39B_uc011lmr.1_Missense_Mutation_p.D320H|TTC39B_uc010mif.1_Missense_Mutation_p.D389H|TTC39B_uc003zls.1_Missense_Mutation_p.D290H|TTC39B_uc010mig.1_Missense_Mutation_p.D358H|TTC39B_uc003zlp.1_5'UTR	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	389							binding			ovary(1)	1						CAAAGCAGATCTGAATAGTAA	0.373		NaN											0	0	0	0.008361	0	25	100									
BNC2	54796	broad.mit.edu	37	9	16437085	16437085	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:16437085G>A	uc003zml.2	-	6	1247	c.1107C>T	c.(1105-1107)TCC>TCT	p.S369S	BNC2_uc011lmw.1_Silent_p.S274S|BNC2_uc003zmm.2_Silent_p.S327S|BNC2_uc003zmq.1_Silent_p.S383S|BNC2_uc003zmr.1_Silent_p.S406S|BNC2_uc003zmp.1_Silent_p.S397S|BNC2_uc010mij.1_Silent_p.S291S|BNC2_uc011lmv.1_Silent_p.S195S|BNC2_uc003zmo.1_Silent_p.S291S|BNC2_uc003zmj.2_Silent_p.S134S|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.S134S|BNC2_uc003zmn.1_Silent_p.S134S	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GAGAAACTTCGGATTCGCTGC	0.483		NaN											0	0	0	0.024245	0	14	138									
MLLT3	4300	broad.mit.edu	37	9	20414109	20414109	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:20414109C>G	uc003zoe.2	-	5	994	c.735G>C	c.(733-735)GAG>GAC	p.E245D	MLLT3_uc011lne.1_Missense_Mutation_p.E213D|MLLT3_uc011lnf.1_Missense_Mutation_p.E242D|MLLT3_uc003zof.2_Missense_Mutation_p.E46D	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		GAACTATTTTCTCTTCTTTCA	0.388		NaN	T	MLL	ALL								0	0	0	0.01441	0	65	210									
MSMP	692094	broad.mit.edu	37	9	35754000	35754000	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:35754000G>C	uc003zyb.1	-	1	273	c.127C>G	c.(127-129)CAA>GAA	p.Q43E		NM_001044264	NP_001037729	Q1L6U9	MSMP_HUMAN	PC3-secreted microprotein precursor	43						extracellular region					0						ACTTTACCTTGAGCTTGGAAG	0.552		NaN											0	0	0	0.01441	0	428	245									
FAM75A6	389730	broad.mit.edu	37	9	43625382	43625382	+	Missense_Mutation	SNP	G	G	A	rs143826416	by1000genomes	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:43625382G>A	uc011lrb.1	-	4	3334	c.3305C>T	c.(3304-3306)CCT>CTT	p.P1102L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1102						integral to membrane					0						CTTGTGAATAGGGGGAAACAT	0.483		NaN											0	0	0	0.013537	0	8	49									
FLJ46321	389763	broad.mit.edu	37	9	84607086	84607086	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:84607086G>A	uc004amn.2	+	4	1748	c.1701G>A	c.(1699-1701)CTG>CTA	p.L567L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	567						integral to membrane					0						CTCAAACCCTGCCCCAAGGTC	0.517		NaN											0	0	0	0.024334	0	25	122									
SPIN1	10927	broad.mit.edu	37	9	91090081	91090081	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:91090081G>A	uc010mqj.2	+	6	1178	c.678G>A	c.(676-678)TCG>TCA	p.S226S	SPIN1_uc004apy.2_Silent_p.S226S|SPIN1_uc004apz.2_Silent_p.S226S|SPIN1_uc010mqk.2_Silent_p.S226S	NM_006717	NP_006708	Q9Y657	SPIN1_HUMAN	spindlin	226					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0						AAGATGGCTCGAAAAGGACTG	0.418		NaN											0	0	0	0.012319	0	21	103									
WNK2	65268	broad.mit.edu	37	9	96015214	96015214	+	Silent	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:96015214G>A	uc004ati.1	+	8	1884	c.1884G>A	c.(1882-1884)TCG>TCA	p.S628S	WNK2_uc011lud.1_Silent_p.S628S|WNK2_uc004atj.2_Silent_p.S628S|WNK2_uc004atk.2_Silent_p.S265S|WNK2_uc010mrc.1_Silent_p.S628S	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	628					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						ACTCAGACTCGCAGAGCAGCC	0.642		NaN											0	0	0	0.009096	0	4	3									
KIAA1529	57653	broad.mit.edu	37	9	100079409	100079409	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:100079409G>A	uc011lut.1	+	21	2180	c.1407G>A	c.(1405-1407)ATG>ATA	p.M469I	KIAA1529_uc004axe.1_Missense_Mutation_p.M469I|KIAA1529_uc004axg.1_Missense_Mutation_p.M330I|KIAA1529_uc011lus.1_Missense_Mutation_p.M287I|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.M330I|KIAA1529_uc011luv.1_Missense_Mutation_p.M327I	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCAACCTGATGGAGTCCACCC	0.612		NaN											0	0	0	0.008361	0	30	125									
MURC	347273	broad.mit.edu	37	9	103348232	103348232	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:103348232C>T	uc004bba.2	+	2	684	c.594C>T	c.(592-594)ATC>ATT	p.I198I		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	198					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				TTGATAATATCAAGAAGGCAT	0.423		NaN											0	0	0	0.01441	0	72	39									
ZNF189	7743	broad.mit.edu	37	9	104171809	104171809	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:104171809C>T	uc004bbh.1	+	3	2035	c.1759C>T	c.(1759-1761)CAG>TAG	p.Q587*	ZNF189_uc004bbg.1_Nonsense_Mutation_p.Q545*|ZNF189_uc004bbi.1_Nonsense_Mutation_p.Q573*|ZNF189_uc011lvk.1_Nonsense_Mutation_p.Q572*	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	587	C2H2-type 15.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				TGTCAACCATCAGAAGATCCA	0.423		NaN											0	0	0	0.01892	0	25	55									
C9orf5	23731	broad.mit.edu	37	9	111812856	111812856	+	Silent	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:111812856G>C	uc004bdt.3	-	13	2003	c.1971C>G	c.(1969-1971)CTC>CTG	p.L657L	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Silent_p.L649L	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	657	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		GTACCAGAGAGAGTACAAAAT	0.443		NaN											0	0	0	0.00499	0	15	76									
SUSD1	64420	broad.mit.edu	37	9	114904756	114904756	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:114904756C>T	uc004bfu.2	-	5	591	c.550G>A	c.(550-552)GAG>AAG	p.E184K	SUSD1_uc010mui.2_Missense_Mutation_p.E184K|SUSD1_uc010muj.2_Missense_Mutation_p.E184K	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	184	Sushi 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						TCTGGAACCTCAGGAGGGGTA	0.398		NaN											0	0	0	0.01441	0	111	82									
TLR4	7099	broad.mit.edu	37	9	120475327	120475327	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:120475327G>C	uc004bjz.2	+	3	1212	c.921G>C	c.(919-921)TTG>TTC	p.L307F	TLR4_uc004bka.2_Missense_Mutation_p.L267F|TLR4_uc004bkb.2_Missense_Mutation_p.L107F	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	307	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTAATTGTTTGACAAATGTTT	0.338		NaN											0	0	0	0.008361	0	30	106									
WDR38	401551	broad.mit.edu	37	9	127617983	127617983	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:127617983C>T	uc004box.2	+	3	317	c.261C>T	c.(259-261)GTC>GTT	p.V87V	WDR38_uc011lzn.1_Silent_p.V76V|WDR38_uc011lzo.1_Silent_p.V87V|WDR38_uc011lzp.1_Intron	NM_001045476	NP_001038941	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	87	WD 2.										0						ACTGCACTGTCCGCCTGTGGG	0.642		NaN									OREG0019485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	77									
PTGES2	80142	broad.mit.edu	37	9	130887585	130887585	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:130887585C>G	uc004bti.2	-	2	893	c.415G>C	c.(415-417)GAG>CAG	p.E139Q	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_5'UTR|PTGES2_uc004btl.2_5'UTR|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	139	Glutaredoxin.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						AACTTGATCTCAGCCCTGCGC	0.602		NaN											0	0	0	0.006122	0	18	8									
PTGES2	80142	broad.mit.edu	37	9	130887694	130887694	+	Silent	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:130887694C>T	uc004bti.2	-	2	784	c.306G>A	c.(304-306)CTG>CTA	p.L102L	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_5'UTR|PTGES2_uc004btl.2_5'UTR|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	102	Glutaredoxin.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						GGTACAGGGTCAGCTGCAGGC	0.637		NaN											0	0	0	0.023175	0	35	23									
MED27	9442	broad.mit.edu	37	9	134889766	134889766	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:134889766C>T	uc004cbe.1	-	3	459	c.437G>A	c.(436-438)CGT>CAT	p.R146H	MED27_uc004cbf.1_Missense_Mutation_p.R146H|MED27_uc011mco.1_Missense_Mutation_p.R146H|MED27_uc004cbg.3_Missense_Mutation_p.R146H	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	146					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		CTTTGGTCTACGTTTGGCAGA	0.428		NaN											0	0	0	0.024334	0	24	73									
MXRA5	25878	broad.mit.edu	37	X	3238916	3238916	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:3238916G>C	uc004crg.3	-	5	4967	c.4810C>G	c.(4810-4812)CAA>GAA	p.Q1604E		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1604						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGGTTAGTTGATGAGAAGCA	0.483		NaN											0	0	0	0.025465	0	42	82									
OFD1	8481	broad.mit.edu	37	X	13780470	13780470	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:13780470C>G	uc004cvp.3	+	18	2754	c.2395C>G	c.(2395-2397)CGA>GGA	p.R799G	OFD1_uc004cvr.3_Missense_Mutation_p.R366G|OFD1_uc011mil.1_Missense_Mutation_p.R366G|OFD1_uc004cvq.3_Missense_Mutation_p.R659G|OFD1_uc010nen.2_Missense_Mutation_p.R798G|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.R758G|OFD1_uc004cvv.3_Missense_Mutation_p.R758G	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	799	Mediates the interaction with SDCCAG8.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						TAGTCTTTATCGAAGACAAAC	0.343		NaN											0	0	0	0.027356	0	24	64									
FAM47B	170062	broad.mit.edu	37	X	34961687	34961687	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:34961687C>G	uc004ddi.1	+	1	757	c.739C>G	c.(739-741)CTC>GTC	p.L247V		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	247	Pro-rich.									ovary(3)|breast(1)	4						CGCATCTCATCTCCGCGTGGA	0.627		NaN											0	0	0	0.024334	0	25	63									
CDK16	5127	broad.mit.edu	37	X	47083838	47083838	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:47083838C>T	uc004dho.2	+	3	653	c.257C>T	c.(256-258)TCA>TTA	p.S86L	CDK16_uc011mli.1_Missense_Mutation_p.S92L|CDK16_uc011mlj.1_Missense_Mutation_p.S86L|CDK16_uc011mlk.1_Missense_Mutation_p.S86L|CDK16_uc011mll.1_Missense_Mutation_p.S160L	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	86							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						GACCAGGCTTCAGCCACGTCC	0.607		NaN											0	0	0	0.020292	0	15	23									
ARHGEF9	23229	broad.mit.edu	37	X	62885870	62885870	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:62885870C>G	uc004dvl.2	-	7	1791	c.952G>C	c.(952-954)GAG>CAG	p.E318Q	ARHGEF9_uc004dvj.1_Missense_Mutation_p.E207Q|ARHGEF9_uc004dvk.1_Intron|ARHGEF9_uc011mos.1_Missense_Mutation_p.E297Q|ARHGEF9_uc004dvm.1_Missense_Mutation_p.E297Q|ARHGEF9_uc011mot.1_Missense_Mutation_p.E265Q|ARHGEF9_uc004dvn.2_Missense_Mutation_p.E325Q	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	318	PH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						TAGATCAGCTCCGAGCTCCTG	0.592		NaN											0	0	0	0.004007	0	16	31									
FAM123B	139285	broad.mit.edu	37	X	63411969	63411969	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:63411969C>A	uc004dvo.2	-	2	1471	c.1198G>T	c.(1198-1200)GAG>TAG	p.E400*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	400	Glu-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						tcttcttcctcctccttaacc	0.343		NaN											1	0	2.35188e-11	0.006122	2.49175e-11	18	42									
FAM123B	139285	broad.mit.edu	37	X	63412290	63412290	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:63412290C>T	uc004dvo.2	-	2	1150	c.877G>A	c.(877-879)GTA>ATA	p.V293I		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	293					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCTGCTACTACCTTCTCCCCT	0.557		NaN											0	0	0	0.011902	0	46	103									
FAM123B	139285	broad.mit.edu	37	X	63412575	63412575	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:63412575C>G	uc004dvo.2	-	2	865	c.592G>C	c.(592-594)GAG>CAG	p.E198Q		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	198					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTGACCCTCTCAGGCCCCTTG	0.577		NaN											0	0	0	0.004007	0	16	35									
MAGEE1	57692	broad.mit.edu	37	X	75649248	75649248	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:75649248C>T	uc004ecm.1	+	1	1132	c.925C>T	c.(925-927)CAG>TAG	p.Q309*		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	309	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CACCTCCGTGCAGCCCACTGC	0.692		NaN											0	0	0	0.004672	0	3	22									
DIAPH2	1730	broad.mit.edu	37	X	96854279	96854279	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:96854279C>G	uc004efu.3	+	27	3665	c.3269C>G	c.(3268-3270)TCA>TGA	p.S1090*		NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	1090					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						TTGGAAAGGTCACGCTCTCGC	0.353		NaN											0	0	0	0.00308	0	7	3									
AVPR2	554	broad.mit.edu	37	X	153171751	153171751	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:153171751C>T	uc004fjh.3	+	2	862	c.791C>T	c.(790-792)GCA>GTA	p.A264V	AVPR2_uc004fjg.3_Missense_Mutation_p.A53V|AVPR2_uc004fji.2_Missense_Mutation_p.A264V	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	264	Cytoplasmic (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	CACGTGTCAGCAGCTGTGGCC	0.657		NaN											0	0	0	0.007413	0	19	18									
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:40713708_40713709delTC	uc001cfe.2	+	1	136_137	c.43_44delTC	c.(43-45)TCTfs	p.S15fs		NM_001008740	NP_001008740	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	15						integral to membrane				ovary(1)	1	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406		NaN											NaN	NaN	NaN	NaN	NaN	8	511	---	---							
PIK3C2B	5287	broad.mit.edu	37	1	204412694	204412697	+	Frame_Shift_Del	DEL	ACTG	ACTG	-			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:204412694_204412697delACTG	uc001haw.2	-	20	3375_3378	c.2896_2899delCAGT	c.(2896-2901)CAGTTCfs	p.Q966fs	PIK3C2B_uc010pqv.1_Frame_Shift_Del_p.Q938fs	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	966_967					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CGGATGCTGAACTGAGAGTCCTTG	0.569		NaN											NaN	NaN	NaN	NaN	NaN	37	254	---	---							
SMARCC2	6601	broad.mit.edu	37	12	56559126	56559127	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:56559126_56559127insG	uc001skb.2	-	26	3220_3221	c.3114_3115insC	c.(3112-3117)CCAGGGfs	p.P1038fs	SMARCC2_uc001skd.2_Frame_Shift_Ins_p.P1069fs|SMARCC2_uc001ska.2_Frame_Shift_Ins_p.P1069fs|SMARCC2_uc001skc.2_Frame_Shift_Ins_p.P1068fs|SMARCC2_uc010sqf.1_Frame_Shift_Ins_p.P958fs	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	1038_1039	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGGGAACCCCTGGTGGGACTG	0.584		NaN											NaN	NaN	NaN	NaN	NaN	8	168	---	---							
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:122812690_122812691insT	uc001ucg.1	-	16	3158_3159	c.3052_3053insA	c.(3052-3054)AGCfs	p.S1018fs	CLIP1_uc001uch.1_Frame_Shift_Ins_p.S1007fs|CLIP1_uc001uci.1_Frame_Shift_Ins_p.S972fs|CLIP1_uc001ucj.1_Frame_Shift_Ins_p.S593fs	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1018	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505		NaN											NaN	NaN	NaN	NaN	NaN	11	220	---	---							
HERC2	8924	broad.mit.edu	37	15	28511100	28511101	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:28511100_28511101insC	uc001zbj.2	-	13	1724_1725	c.1618_1619insG	c.(1618-1620)GTGfs	p.V540fs	HERC2_uc001zbl.1_Frame_Shift_Ins_p.V235fs	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	540	RCC1 1.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGCGGAGATCACCTTAGGCTCC	0.51		NaN											NaN	NaN	NaN	NaN	NaN	7	54	---	---							
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:26022304_26022306delCTG	uc002rgs.2	-	4	572_574	c.351_353delCAG	c.(349-354)AGCAGT>AGT	p.117_118SS>S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	117_118	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463		NaN											NaN	NaN	NaN	NaN	NaN	7	234	---	---							
ERBB2IP	55914	broad.mit.edu	37	5	65349986	65349987	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:65349986_65349987insT	uc003juk.1	+	21	3148_3149	c.2840_2841insT	c.(2839-2841)GATfs	p.D947fs	ERBB2IP_uc003jui.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc003juj.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc011cqx.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc011cqy.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Frame_Shift_Ins_p.D943fs|ERBB2IP_uc003jul.1_Frame_Shift_Ins_p.D943fs	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	947					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TTCAAGTTTGATTCAAATCATA	0.386		NaN											NaN	NaN	NaN	NaN	NaN	13	69	---	---							
FAM120B	84498	broad.mit.edu	37	6	170697422	170697423	+	Frame_Shift_Ins	INS	-	-	CG			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:170697422_170697423insCG	uc003qxp.2	+	7	2439_2440	c.2331_2332insCG	c.(2329-2334)GTCCGCfs	p.V777fs	FAM120B_uc003qxo.1_Frame_Shift_Ins_p.V777fs|FAM120B_uc011ehd.1_Frame_Shift_Ins_p.V109fs|FAM120B_uc010kla.1_RNA	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	777_778					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		CCCTTCTCGTCCGCGGCCTCAC	0.525		NaN											NaN	NaN	NaN	NaN	NaN	17	53	---	---							
PMS2	5395	broad.mit.edu	37	7	6043619	6043621	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:6043619_6043621delTTC	uc003spl.2	-	3	319_321	c.232_234delGAA	c.(232-234)GAAdel	p.E78del	PMS2_uc003spj.2_In_Frame_Del_p.R6del|PMS2_uc003spk.2_5'UTR|PMS2_uc011jwl.1_5'UTR|PMS2_uc010ktg.2_5'UTR|PMS2_uc010kte.2_In_Frame_Del_p.E78del|PMS2_uc010ktf.1_In_Frame_Del_p.E78del	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	78					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTTCGAAGTTTTCTTCTTCTACC	0.31		NaN	Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				NaN	NaN	NaN	NaN	NaN	29	301	---	---