Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
MIB2	142678	broad.mit.edu	37	1	1563943	1563943	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:1563943G>A	uc001agg.2	+	16	2344	c.2217G>A	c.(2215-2217)GTG>GTA	p.V739V	MIB2_uc001agh.2_Silent_p.V725V|MIB2_uc001agi.2_Silent_p.V735V|MIB2_uc001agj.2_Silent_p.V580V|MIB2_uc001agk.2_Silent_p.V674V|MIB2_uc001agl.1_Silent_p.V695V|MIB2_uc001agm.2_Silent_p.V616V|MIB2_uc010nyq.1_Silent_p.V695V|MIB2_uc009vkh.2_Silent_p.V545V|MIB2_uc001agn.2_Silent_p.V371V|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	739	ANK 7.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGCCCACGTGGGGCTGGTGC	0.697		NaN											0	0	0	1	0	3	9									
PTCHD2	57540	broad.mit.edu	37	1	11586880	11586880	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:11586880A>G	uc001ash.3	+	13	2924	c.2786A>G	c.(2785-2787)CAG>CGG	p.Q929R	PTCHD2_uc001asi.1_Missense_Mutation_p.Q929R	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	929	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		ACCAAGGAGCAGCAGCACACC	0.592		NaN											0	0	0	1	0	13	40									
NPPB	4879	broad.mit.edu	37	1	11918889	11918889	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:11918889A>T	uc001atj.2	-	1	104	c.2T>A	c.(1-3)ATG>AAG	p.M1K		NM_002521	NP_002512	P16860	ANFB_HUMAN	natriuretic peptide precursor B preproprotein	1					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	CTGGGGATCCATGTCTCTGGA	0.532		NaN											0	0	0	1	0	24	43									
DDI2	84301	broad.mit.edu	37	1	15959933	15959933	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:15959933G>C	uc001awx.1	+	4	602	c.506_splice	c.e4-1	p.E169_splice	DDI2_uc001aww.2_Splice_Site_p.E169_splice|DDI2_uc009voj.1_Splice_Site	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2						proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TATTTTTGTAGAGAAATTTTC	0.393		NaN											0	0	0	1	0	78	149									
DDI2	84301	broad.mit.edu	37	1	15978369	15978369	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:15978369C>G	uc001awx.1	+	8	1258	c.1162C>G	c.(1162-1164)CAA>GAA	p.Q388E	DDI2_uc009voj.1_Missense_Mutation_p.Q129E	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	388					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AGAAGCCCTTCAAAAATCAGC	0.512		NaN											0	0	0	1	0	13	16									
CLCNKA	1187	broad.mit.edu	37	1	16358726	16358726	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:16358726G>A	uc001axu.2	+	17	1865	c.1785G>A	c.(1783-1785)CAG>CAA	p.Q595Q	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.Q595Q|CLCNKA_uc010obw.1_Silent_p.Q552Q|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010oby.1_3'UTR	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	595	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GCATCGTGCAGAGGGCCCAGC	0.642		NaN											0	0	0	1	0	15	33									
KLHDC7A	127707	broad.mit.edu	37	1	18808004	18808004	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:18808004G>A	uc001bax.2	+	1	581	c.529G>A	c.(529-531)GAC>AAC	p.D177N	KLHDC7A_uc009vpg.2_5'UTR	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	177						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGCAGCAGCCGACGGCAGCTG	0.607		NaN											0	0	0	1	0	11	30									
FAM54B	56181	broad.mit.edu	37	1	26153217	26153217	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:26153217G>A	uc001bkq.3	+	5	561	c.351G>A	c.(349-351)CTG>CTA	p.L117L	FAM54B_uc001bkr.3_Silent_p.L117L|FAM54B_uc010oet.1_Silent_p.L150L|FAM54B_uc009vrz.2_Silent_p.L114L|FAM54B_uc001bks.3_Silent_p.L117L|FAM54B_uc001bkt.3_Silent_p.L117L|FAM54B_uc001bku.3_Silent_p.L114L|FAM54B_uc001bkv.3_Silent_p.L20L	NM_001099625	NP_001093095	Q9H019	FA54B_HUMAN	hypothetical protein LOC56181 isoform a	117										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.96e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.00095)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTGGCCCTGAAGAAGCCAG	0.607		NaN											0	0	0	1	0	33	60									
SLC9A1	6548	broad.mit.edu	37	1	27480481	27480481	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:27480481C>T	uc001bnm.2	-	1	971	c.345G>A	c.(343-345)ATG>ATA	p.M115I	SLC9A1_uc010ofk.1_5'UTR|SLC9A1_uc001bnn.2_Missense_Mutation_p.M115I	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	115	Helical; Name=M2; (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TACCTATCTTCATGAGGCAGG	0.587		NaN											0	0	0	1	0	23	50									
COL16A1	1307	broad.mit.edu	37	1	32157645	32157645	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:32157645G>T	uc001btk.1	-	17	1583	c.1218C>A	c.(1216-1218)GAC>GAA	p.D406E	COL16A1_uc001btj.1_Missense_Mutation_p.D235E|COL16A1_uc001btl.3_Missense_Mutation_p.D406E	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	406	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TGATGCCTCCGTCGCCCTTCT	0.647		NaN											1	0	2.39187e-15	1	2.50233e-15	21	49									
CSMD2	114784	broad.mit.edu	37	1	33989000	33989000	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:33989000A>G	uc001bxn.1	-	66	10013	c.9984T>C	c.(9982-9984)GAT>GAC	p.D3328D	CSMD2_uc001bxm.1_Silent_p.D3472D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3328	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAGATGAAAATCTTCTTTCT	0.383		NaN											0	0	0	1	0	6	3									
SFPQ	6421	broad.mit.edu	37	1	35657035	35657035	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:35657035G>A	uc001bys.2	-	2	1017	c.924C>T	c.(922-924)ATC>ATT	p.I308I	SFPQ_uc001byr.2_5'Flank	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	308	RRM 1.				alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CATCCTCCGTGATATCAGCAG	0.403		NaN	T	TFE3	papillary renal cell								0	0	0	1	0	15	16									
THRAP3	9967	broad.mit.edu	37	1	36762187	36762187	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:36762187G>A	uc001cae.3	+	9	2343	c.2119G>A	c.(2119-2121)GAG>AAG	p.E707K	THRAP3_uc001caf.3_Missense_Mutation_p.E707K	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	707					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTGATAGGCTGAGGGAAAATA	0.408		NaN	T	USP6	aneurysmal bone cysts								0	0	0	1	0	27	15									
ECHDC2	55268	broad.mit.edu	37	1	53387303	53387303	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:53387303G>A	uc001cup.3	-	1	289	c.43C>T	c.(43-45)CGG>TGG	p.R15W	ECHDC2_uc001cun.2_5'UTR|ECHDC2_uc001cuo.3_Missense_Mutation_p.R15W|ECHDC2_uc010onk.1_5'UTR|ECHDC2_uc010onl.1_5'Flank|ECHDC2_uc010onm.1_5'UTR|ECHDC2_uc010onn.1_5'UTR	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	15					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						CCGCGGGCCCGAAGGGGCCTC	0.731		NaN											0	0	0	1	0	5	6									
TM2D1	83941	broad.mit.edu	37	1	62190818	62190818	+	Translation_Start_Site	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:62190818C>T	uc001czz.1	-	1	278	c.-25G>A	c.(-27--23)AAGTG>AAATG			NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor						apoptosis					ovary(1)	1						TTTCTCGCCACTTCCGCTTCC	0.642		NaN											0	0	0	1	0	27	37									
C1orf141	400757	broad.mit.edu	37	1	67560923	67560923	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:67560923G>A	uc001ddl.1	-	6	709	c.598C>T	c.(598-600)CAC>TAC	p.H200Y	C1orf141_uc001ddm.1_Missense_Mutation_p.H200Y|C1orf141_uc001ddn.1_Intron	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	200										ovary(1)	1						ATTACCATGTGAGAAGTTACT	0.343		NaN											0	0	0	1	0	7	15									
ANKRD13C	81573	broad.mit.edu	37	1	70736618	70736618	+	Silent	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:70736618T>C	uc001dex.3	-	12	1742	c.1416A>G	c.(1414-1416)GTA>GTG	p.V472V	ANKRD13C_uc009wbk.2_Silent_p.V437V	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	472					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						AGGGAGCTACTACTTCTAAAA	0.284		NaN											0	0	0	1	0	11	23									
ZRANB2	9406	broad.mit.edu	37	1	71544365	71544365	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:71544365C>T	uc001dft.2	-	2	150	c.83G>A	c.(82-84)AGA>AAA	p.R28K	uc001dfu.1_5'Flank|ZRANB2_uc001dfs.2_Missense_Mutation_p.R28K	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	28	RanBP2-type 1.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACAGCTGGTTCTTCTAGCAAA	0.264		NaN											0	0	0	1	0	31	64									
GBP4	115361	broad.mit.edu	37	1	89654466	89654466	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:89654466C>T	uc001dnb.2	-	8	1325	c.1209G>A	c.(1207-1209)GAG>GAA	p.E403E		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	403				IEKKKGDFV -> KKKKKKKKK (in Ref. 5; AAH17889).		cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CCTTCTTTTTCTCTATGGTGT	0.448		NaN											0	0	0	1	0	58	91									
DR1	1810	broad.mit.edu	37	1	93812391	93812391	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:93812391G>A	uc001dpu.2	+	1	914	c.189G>A	c.(187-189)AAG>AAA	p.K63K	uc001dps.2_5'Flank|uc001dpt.1_5'Flank|DR1_uc010otj.1_Silent_p.K63K	NM_001938	NP_001929	Q01658	NC2B_HUMAN	down-regulator of transcription 1	63					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex	sequence-specific DNA binding|TBP-class protein binding|transcription corepressor activity				0		all_lung(203;0.00252)|Lung NSC(277;0.011)|Melanoma(281;0.155)		all cancers(265;0.0032)|GBM - Glioblastoma multiforme(16;0.0165)|Epithelial(280;0.0977)		AATCGGAAAAGAAGACCATCT	0.468		NaN											0	0	0	1	0	7	14									
DPYD	1806	broad.mit.edu	37	1	98187148	98187148	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:98187148T>A	uc001drv.2	-	5	538	c.401A>T	c.(400-402)GAT>GTT	p.D134V	DPYD_uc010oub.1_RNA|DPYD_uc001drw.2_Missense_Mutation_p.D134V	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	134					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TACACAAAGATCAGAGGTTGG	0.383		NaN											0	0	0	1	0	12	61									
LPPR4	9890	broad.mit.edu	37	1	99772144	99772144	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:99772144G>C	uc001dse.2	+	7	1976	c.1870G>C	c.(1870-1872)GAG>CAG	p.E624Q	LPPR4_uc010oue.1_Missense_Mutation_p.E566Q	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	624							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGTGAGGGTTGAGGCTCACCC	0.562		NaN											0	0	0	1	0	20	37									
CELSR2	1952	broad.mit.edu	37	1	109805873	109805873	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:109805873C>T	uc001dxa.3	+	8	4879	c.4818C>T	c.(4816-4818)GGC>GGT	p.G1606G		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1606	Extracellular (Potential).|EGF-like 4; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCTTTGGGGGCAAGAGCTGCG	0.637		NaN											0	0	0	1	0	8	26									
SLC16A1	6566	broad.mit.edu	37	1	113456585	113456585	+	Silent	SNP	A	A	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:113456585A>C	uc001ecx.2	-	5	2263	c.1431T>G	c.(1429-1431)GTT>GTG	p.V477V	SLC16A1_uc001ecy.2_Silent_p.V477V	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	477	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CTGCTTTGGTAACTTCATTTG	0.458		NaN											0	0	0	1	0	55	75									
PHTF1	10745	broad.mit.edu	37	1	114246790	114246790	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:114246790C>T	uc009wgp.1	-	14	2256	c.1804_splice	c.e14-1	p.R602_splice	PHTF1_uc001edn.2_Intron|PHTF1_uc001edm.2_Splice_Site_p.R359_splice	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCCCCGTCTCTGTGGAGTGA	0.428		NaN											0	0	0	1	0	11	22									
MAN1A2	10905	broad.mit.edu	37	1	117944919	117944919	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:117944919G>A	uc001ehd.1	+	2	1135	c.414G>A	c.(412-414)CAG>CAA	p.Q138Q	MAN1A2_uc009whg.1_Intron	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	138	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		CAGAAATTCAGACAGAGAAAA	0.403		NaN											0	0	0	1	0	26	43									
WDR3	10885	broad.mit.edu	37	1	118502031	118502031	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:118502031G>C	uc010oxe.1	+	27	2859	c.2793G>C	c.(2791-2793)AAG>AAC	p.K931N	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	931						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		agaagaggaagaggaaaaaga	0.299		NaN											0	0	0	1	0	14	39									
TBX15	6913	broad.mit.edu	37	1	119456781	119456781	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:119456781G>A	uc001ehl.1	-	6	880	c.565C>T	c.(565-567)CGA>TGA	p.R189*		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	295	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AAAGGGTTTCGGTCAATTTTT	0.333		NaN											0	0	0	1	0	15	23									
PDE4DIP	9659	broad.mit.edu	37	1	144874026	144874026	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:144874026G>A	uc001elw.3	-	31	5222	c.4931C>T	c.(4930-4932)TCC>TTC	p.S1644F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1600F|PDE4DIP_uc001elv.3_Missense_Mutation_p.S651F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1644					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGATGGATGGAATCTATAAA	0.458		NaN	T	PDGFRB	MPD								0	0	0	1	0	58	267									
PDE4DIP	9659	broad.mit.edu	37	1	144917918	144917918	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:144917918G>A	uc001elw.3	-	11	1659	c.1368C>T	c.(1366-1368)CTC>CTT	p.L456L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L522L|PDE4DIP_uc001emc.1_Silent_p.L456L|PDE4DIP_uc001emd.1_Silent_p.L456L|PDE4DIP_uc001emb.1_Silent_p.L619L|PDE4DIP_uc001eme.1_5'UTR|PDE4DIP_uc001emf.1_Silent_p.L243L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	456	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GATACTGTAGGAGCTCCCGAA	0.284		NaN	T	PDGFRB	MPD								0	0	0	1	0	51	254									
TCHH	7062	broad.mit.edu	37	1	152084109	152084109	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:152084109G>A	uc001ezp.2	-	2	1584	c.1584C>T	c.(1582-1584)CTC>CTT	p.L528L	TCHH_uc009wne.1_Silent_p.L528L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	528	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCGCTGCTGGAGCCTCTCTT	0.652		NaN											0	0	0	1	0	47	92									
CREB3L4	148327	broad.mit.edu	37	1	153941087	153941087	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:153941087G>A	uc001fdn.3	+	2	352	c.86G>A	c.(85-87)GGA>GAA	p.G29E	SLC39A1_uc001fdl.2_5'Flank|CREB3L4_uc010pef.1_5'UTR|CREB3L4_uc001fdo.3_Missense_Mutation_p.G29E|CREB3L4_uc001fdm.1_Missense_Mutation_p.G29E|CREB3L4_uc001fdp.1_Missense_Mutation_p.G29E|CREB3L4_uc010peg.1_Missense_Mutation_p.G29E|CREB3L4_uc001fdr.2_Missense_Mutation_p.G29E|CREB3L4_uc001fdq.2_Missense_Mutation_p.G29E	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	29	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGGAGCTGGGACTCCACTGC	0.617		NaN											0	0	0	1	0	30	39									
CREB3L4	148327	broad.mit.edu	37	1	153941855	153941855	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:153941855G>T	uc001fdn.3	+	4	733	c.467G>T	c.(466-468)AGT>ATT	p.S156I	SLC39A1_uc001fdl.2_5'Flank|CREB3L4_uc010pef.1_Missense_Mutation_p.S9I|CREB3L4_uc001fdo.3_Missense_Mutation_p.S136I|CREB3L4_uc001fdm.1_Missense_Mutation_p.S156I|CREB3L4_uc001fdp.1_Missense_Mutation_p.S136I|CREB3L4_uc010peg.1_3'UTR|CREB3L4_uc001fdr.2_Missense_Mutation_p.S156I|CREB3L4_uc001fdq.2_Missense_Mutation_p.S136I	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	156	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGCATGGTCAGTGAGCTGCCC	0.557		NaN											1	0	1.62565e-12	1	1.69171e-12	35	45									
KRTCAP2	200185	broad.mit.edu	37	1	155145044	155145044	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:155145044C>T	uc001fho.2	-	3	324	c.298G>A	c.(298-300)GAG>AAG	p.E100K	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fhp.1_Missense_Mutation_p.E100K|TRIM46_uc009wpe.1_5'Flank|TRIM46_uc010pez.1_5'Flank|TRIM46_uc001fhq.2_5'Flank|TRIM46_uc001fhr.2_5'Flank|TRIM46_uc001fhs.1_5'Flank|TRIM46_uc001fht.1_5'Flank|TRIM46_uc010pfa.1_5'Flank|TRIM46_uc001fhu.1_5'Flank|TRIM46_uc009wpg.1_5'Flank|TRIM46_uc009wpf.2_5'Flank|TRIM46_uc001fhv.3_5'Flank|TRIM46_uc001fhw.1_5'Flank	NM_173852	NP_776251	Q8N6L1	KTAP2_HUMAN	keratinocyte associated protein 2	100	Helical; (Potential).					integral to membrane					0	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.18e-10)|all cancers(21;8.39e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CACTTACTCTCAGGGAAGATC	0.418		NaN											0	0	0	1	0	18	41									
ASH1L	55870	broad.mit.edu	37	1	155316194	155316194	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:155316194C>G	uc009wqq.2	-	21	8365	c.7885G>C	c.(7885-7887)GAC>CAC	p.D2629H	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2624H|MIR555_hsa-mir-555|MI0003561_RNA	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2629	PHD-type.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGCCTTGGGTCACACTGCTCA	0.478		NaN											0	0	0	1	0	39	51									
LRRC52	440699	broad.mit.edu	37	1	165532806	165532806	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:165532806G>A	uc001gde.2	+	2	743	c.687G>A	c.(685-687)GGG>GGA	p.G229G	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	229	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CCCGGGTGGGGAACCCACTCC	0.557		NaN											0	0	0	1	0	13	26									
DUSP27	92235	broad.mit.edu	37	1	167095044	167095044	+	Missense_Mutation	SNP	G	G	A	rs144186156		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:167095044G>A	uc001geb.1	+	5	676	c.676G>A	c.(676-678)GAA>AAA	p.E226K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	226	Tyrosine-protein phosphatase.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GGTCAGCAGCGAAATGGGCAT	0.478		NaN											0	0	0	1	0	26	42									
FMO2	2327	broad.mit.edu	37	1	171174530	171174530	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:171174530G>A	uc001ghk.1	+	7	1057	c.940G>A	c.(940-942)GAG>AAG	p.E314K	FMO2_uc010pmd.1_Missense_Mutation_p.E94K	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	314					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCCATCTTTGAGGATGGAAC	0.413		NaN											0	0	0	1	0	25	32									
RC3H1	149041	broad.mit.edu	37	1	173953689	173953689	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:173953689C>T	uc001gju.3	-	2	387	c.300G>A	c.(298-300)AAG>AAA	p.K100K	RC3H1_uc010pms.1_Silent_p.K100K|RC3H1_uc001gjv.2_Silent_p.K100K|RC3H1_uc010pmt.1_Silent_p.K100K	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	100					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTACACATTTCTTGGCTTCCT	0.383		NaN											0	0	0	1	0	12	16									
C1orf125	126859	broad.mit.edu	37	1	179478451	179478451	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:179478451C>G	uc001gmo.2	+	21	2536	c.2409C>G	c.(2407-2409)ATC>ATG	p.I803M	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Intron|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	803											0						ATGAATGGATCAACACATGCT	0.348		NaN											0	0	0	1	0	14	30									
CEP350	9857	broad.mit.edu	37	1	179993589	179993589	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:179993589G>A	uc001gnt.2	+	14	3805	c.3422G>A	c.(3421-3423)AGA>AAA	p.R1141K	CEP350_uc009wxl.2_Missense_Mutation_p.R1140K|CEP350_uc001gnu.2_Missense_Mutation_p.R974K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1141	Ser-rich.					centrosome|nucleus|spindle				ovary(4)	4						CATTCTAACAGAAAGTCTGCC	0.413		NaN											0	0	0	1	0	21	27									
PLEKHA6	22874	broad.mit.edu	37	1	204228552	204228552	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204228552C>G	uc001hau.2	-	8	1158	c.841G>C	c.(841-843)GGG>CGG	p.G281R	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	281	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GCTGTGCTCCCTGGCCGGCTT	0.657		NaN											0	0	0	1	0	25	51									
PLEKHA6	22874	broad.mit.edu	37	1	204228723	204228723	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204228723C>G	uc001hau.2	-	8	987	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	224	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TCTGGCCTCTCAGGCCTTCTC	0.652		NaN											0	0	0	1	0	19	56									
PLEKHA6	22874	broad.mit.edu	37	1	204228847	204228847	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204228847C>G	uc001hau.2	-	8	863	c.546G>C	c.(544-546)GAG>GAC	p.E182D	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	182	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GTGGGACGTTCTCCGAGTCTG	0.627		NaN											0	0	0	1	0	12	32									
SYT14	255928	broad.mit.edu	37	1	210334350	210334350	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:210334350A>T	uc009xcv.2	+	8	1703	c.1631A>T	c.(1630-1632)CAG>CTG	p.Q544L	SYT14_uc001hhs.3_Missense_Mutation_p.Q608L|SYT14_uc001hht.3_Missense_Mutation_p.Q563L|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.Q589L|SYT14_uc010pso.1_Missense_Mutation_p.Q506L|SYT14_uc010psp.1_Missense_Mutation_p.Q82L	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	544	Cytoplasmic (Potential).					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		TCAAAAGGACAGCAAGTATGT	0.388		NaN											0	0	0	1	0	35	62									
KCNK2	3776	broad.mit.edu	37	1	215259819	215259819	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:215259819C>T	uc001hkq.2	+	2	324	c.155C>T	c.(154-156)ACG>ATG	p.T52M	KCNK2_uc001hko.2_Missense_Mutation_p.T48M|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.T37M	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	52	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	GAGAGTGACACGACCATTAAT	0.512		NaN											0	0	0	1	0	15	32									
WDR26	80232	broad.mit.edu	37	1	224581534	224581534	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:224581534A>C	uc001hop.3	-	13	1881	c.1515T>G	c.(1513-1515)ATT>ATG	p.I505M	WDR26_uc001hoq.3_Missense_Mutation_p.I489M|WDR26_uc010pvh.1_Missense_Mutation_p.I212M	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	652						cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		TATTACCTTCAATATTCTGGT	0.388		NaN											0	0	0	1	0	25	41									
PCNXL2	80003	broad.mit.edu	37	1	233394514	233394514	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:233394514C>T	uc001hvl.2	-	5	1329	c.1094G>A	c.(1093-1095)GGA>GAA	p.G365E	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	365						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGTGGGTCTCCGGGTTGAGA	0.517		NaN											0	0	0	1	0	30	65									
ZNF238	10472	broad.mit.edu	37	1	244218534	244218534	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:244218534G>A	uc001iae.2	+	1	1953	c.1431G>A	c.(1429-1431)CAG>CAA	p.Q477Q	ZNF238_uc001iad.3_Silent_p.Q486Q|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	477	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			GGTTCACGCAGTCCGGGGACC	0.587		NaN											0	0	0	1	0	14	42									
AHCTF1	25909	broad.mit.edu	37	1	247024465	247024465	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:247024465C>T	uc001ibu.1	-	28	3875	c.3868G>A	c.(3868-3870)GAA>AAA	p.E1290K	AHCTF1_uc001ibv.1_Missense_Mutation_p.E1299K|AHCTF1_uc009xgs.1_Missense_Mutation_p.E151K|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1290	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TCATCCATTTCTTGATGCTCC	0.423		NaN											0	0	0	1	0	15	30									
NLRP3	114548	broad.mit.edu	37	1	247588651	247588651	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:247588651G>A	uc001icr.2	+	5	2044	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	NLRP3_uc001ics.2_Missense_Mutation_p.E636K|NLRP3_uc001icu.2_Missense_Mutation_p.E636K|NLRP3_uc001icw.2_Missense_Mutation_p.E636K|NLRP3_uc001icv.2_Missense_Mutation_p.E636K|NLRP3_uc010pyw.1_Missense_Mutation_p.E634K|NLRP3_uc001ict.1_Missense_Mutation_p.E634K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	636					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGTTTGTACGAGATGCAGGA	0.478		NaN											0	0	0	1	0	20	30									
KLF6	1316	broad.mit.edu	37	10	3824148	3824148	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:3824148G>A	uc001iha.2	-	2	628	c.361C>T	c.(361-363)CCC>TCC	p.P121S	KLF6_uc010qaj.1_Missense_Mutation_p.P121S|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Missense_Mutation_p.P121S|KLF6_uc001ihb.2_Missense_Mutation_p.P121S	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	121					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		TTGGCCGTGGGAGAAAGTTCC	0.532		NaN									OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	45	93									
ATP5C1	509	broad.mit.edu	37	10	7844317	7844317	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:7844317C>T	uc001iju.2	+	7	800	c.722C>T	c.(721-723)TCT>TTT	p.S241F	ATP5C1_uc009xiq.1_Missense_Mutation_p.S241F|ATP5C1_uc010qbc.1_Missense_Mutation_p.S192F|ATP5C1_uc001ijv.2_Missense_Mutation_p.S241F	NM_001001973	NP_001001973	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	241					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						ATCTACTACTCTCTGAAGGAG	0.448		NaN											0	0	0	1	0	14	40									
PRPF18	8559	broad.mit.edu	37	10	13652044	13652044	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:13652044G>C	uc001imp.2	+	5	517	c.369G>C	c.(367-369)TTG>TTC	p.L123F	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	123					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						CTTAGGGATTGAGGAATGATT	0.383		NaN											0	0	0	1	0	23	62									
THNSL1	79896	broad.mit.edu	37	10	25312422	25312422	+	Silent	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:25312422C>A	uc001isi.3	+	3	599	c.270C>A	c.(268-270)ATC>ATA	p.I90I	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	90					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	ATGATGATATCCTTGAAAAAA	0.383		NaN											1	0	1.06647e-15	1	1.11771e-15	38	73									
GPR158	57512	broad.mit.edu	37	10	25464862	25464862	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:25464862C>G	uc001isj.2	+	1	573	c.513C>G	c.(511-513)ATC>ATG	p.I171M	LOC100128811_uc010qde.1_Missense_Mutation_p.E30D	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	171	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AGCCCAGCATCTCCCGGGCGG	0.647		NaN											0	0	0	1	0	18	36									
ABI1	10006	broad.mit.edu	37	10	27048155	27048155	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:27048155G>A	uc001isx.2	-	9	1081	c.914C>T	c.(913-915)TCA>TTA	p.S305L	ABI1_uc001ite.2_Missense_Mutation_p.S272L|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Missense_Mutation_p.S278L|ABI1_uc001ita.2_Missense_Mutation_p.S278L|ABI1_uc001isz.2_Missense_Mutation_p.S273L|ABI1_uc001itb.2_Missense_Mutation_p.S322L|ABI1_uc001itc.2_Missense_Mutation_p.S277L|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Missense_Mutation_p.S277L|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Missense_Mutation_p.S144L	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	305	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						ACCAGGAGCTGAGCCCGGGGC	0.498		NaN											0	0	0	1	0	14	47									
KIAA1462	57608	broad.mit.edu	37	10	30316005	30316005	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:30316005A>G	uc001iux.2	-	2	3131	c.3072T>C	c.(3070-3072)AGT>AGC	p.S1024S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.S886S|KIAA1462_uc009xle.1_Silent_p.S1024S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1024										ovary(4)	4						TCTCTCCACCACTGTCAAACT	0.582		NaN											0	0	0	1	0	54	80									
HK1	3098	broad.mit.edu	37	10	71119661	71119661	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:71119661G>A	uc001jpl.3	+	3	336	c.235G>A	c.(235-237)GAT>AAT	p.D79N	HK1_uc001jpg.3_Missense_Mutation_p.D67N|HK1_uc001jph.3_Missense_Mutation_p.D83N|HK1_uc001jpi.3_Missense_Mutation_p.D83N|HK1_uc001jpj.3_Missense_Mutation_p.D114N|HK1_uc001jpk.3_Missense_Mutation_p.D78N|HK1_uc009xqd.2_Intron	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	79	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						AGAAAAGGGAGATTTCATTGC	0.483		NaN											0	0	0	1	0	32	53									
NPFFR1	64106	broad.mit.edu	37	10	72026099	72026099	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:72026099C>T	uc010qjk.1	-	1	56	c.50G>A	c.(49-51)GGG>GAG	p.G17E		NM_022146	NP_071429	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	19	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide receptor activity				0						AGTGTTAGTCCCATTCTGACT	0.552		NaN											0	0	0	1	0	5	21									
CDH23	64072	broad.mit.edu	37	10	73553278	73553278	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:73553278C>A	uc001jrx.3	+	46	6970	c.6593C>A	c.(6592-6594)GCC>GAC	p.A2198D	CDH23_uc001jsg.3_5'Flank|CDH23_uc001jsh.3_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2198	Cadherin 21.|Extracellular (Potential).			EFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVG IVAKDDTDRLVPNQEDAFAVNIN -> ASWEGQSHVTQAYE EAVGPPQPQVPDSTGDRHPLWGLGGFGQEHPWEGQILGGSS QAEPGLVWS (in Ref. 6; BAB61902).	calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						AATATCACGGCCATTGACCAC	0.572		NaN											1	0	2.89027e-11	1	2.99713e-11	23	23									
OIT3	170392	broad.mit.edu	37	10	74684374	74684374	+	Missense_Mutation	SNP	G	G	A	rs139078371		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:74684374G>A	uc001jte.1	+	7	1557	c.1339G>A	c.(1339-1341)GTC>ATC	p.V447I	OIT3_uc009xqs.1_Intron	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	447	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					GATCGACGAGGTCCTGAAATA	0.552		NaN											0	0	0	1	0	14	34									
ECD	11319	broad.mit.edu	37	10	74899248	74899248	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:74899248G>A	uc001jtn.2	-	11	1483	c.1240C>T	c.(1240-1242)CAG>TAG	p.Q414*	ECD_uc009xqx.2_Nonsense_Mutation_p.Q447*|ECD_uc009xqy.2_Nonsense_Mutation_p.Q371*|ECD_uc001jto.2_Nonsense_Mutation_p.Q113*	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	414					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					TCTAACCACTGGTCATCTGAA	0.428		NaN											0	0	0	1	0	37	72									
LRIT2	340745	broad.mit.edu	37	10	85984111	85984111	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:85984111C>T	uc001kcy.2	-	2	878	c.870G>A	c.(868-870)CTG>CTA	p.L290L	LRIT2_uc010qmc.1_Silent_p.L290L	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	290	Ig-like.					integral to membrane				ovary(2)	2						TCCACATACTCAGGGGATAAG	0.527		NaN											0	0	0	1	0	24	21									
PLCE1	51196	broad.mit.edu	37	10	96012152	96012152	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:96012152C>G	uc001kjk.2	+	9	3810	c.3176C>G	c.(3175-3177)CCC>CGC	p.P1059R	PLCE1_uc010qnx.1_Missense_Mutation_p.P1059R|PLCE1_uc001kjm.2_Missense_Mutation_p.P751R	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1059					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GCTCGAAACCCCAGCCCCGGA	0.507		NaN											0	0	0	1	0	14	44									
TLX1	3195	broad.mit.edu	37	10	102894051	102894051	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:102894051G>A	uc001ksw.2	+	2	926	c.688G>A	c.(688-690)GAG>AAG	p.E230K		NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	230	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GGCCTCGGCCGAGCGCGCCGC	0.602		NaN	T	TRB@|TRD@	T-ALL								0	0	0	1	0	10	9									
LDB1	8861	broad.mit.edu	37	10	103868831	103868831	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:103868831C>T	uc009xwz.2	-	10	1303	c.960G>A	c.(958-960)AAG>AAA	p.K320K	LDB1_uc001kuk.3_Silent_p.K284K|LDB1_uc001kul.3_Silent_p.K284K	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	320					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GGCTCTTCTTCTTGCTGTTGC	0.592		NaN											0	0	0	1	0	22	37									
LDB1	8861	broad.mit.edu	37	10	103869736	103869736	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:103869736C>T	uc009xwz.2	-	7	933	c.590G>A	c.(589-591)TGG>TAG	p.W197*	LDB1_uc001kuk.3_Nonsense_Mutation_p.W161*|LDB1_uc001kul.3_Nonsense_Mutation_p.W161*	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	197					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GCTGAAGTGCCACGTCTTTAT	0.602		NaN											0	0	0	1	0	18	38									
ABLIM1	3983	broad.mit.edu	37	10	116307492	116307492	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:116307492C>T	uc010qsg.1	-	5	816	c.717G>A	c.(715-717)CTG>CTA	p.L239L	ABLIM1_uc010qsh.1_Silent_p.L179L|ABLIM1_uc010qsi.1_Silent_p.L179L|ABLIM1_uc010qsk.1_Silent_p.L163L|ABLIM1_uc009xyp.2_Silent_p.L173L|ABLIM1_uc009xyo.2_Silent_p.L87L	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	239	LIM zinc-binding 3.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CCAGCGCCAGCAGCGCCTGCC	0.552		NaN											0	0	0	1	0	12	19									
WDR11	55717	broad.mit.edu	37	10	122637962	122637962	+	Missense_Mutation	SNP	C	C	T	rs112914841		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:122637962C>T	uc010qtf.1	+	12	1892	c.1654C>T	c.(1654-1656)CTT>TTT	p.L552F	WDR11_uc010qte.1_Missense_Mutation_p.L154F|WDR11_uc001lfd.1_Missense_Mutation_p.L70F	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	552						integral to membrane					0						ACTGGTTGATCTTCCAACAGG	0.333		NaN											0	0	0	1	0	16	28									
TACC2	10579	broad.mit.edu	37	10	123846157	123846157	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:123846157C>T	uc001lfv.2	+	4	4502	c.4142C>T	c.(4141-4143)TCC>TTC	p.S1381F	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.S1381F|TACC2_uc010qtv.1_Missense_Mutation_p.S1381F	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1381						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGAGAGCCTTCCCAGGACCCA	0.612		NaN											0	0	0	1	0	18	32									
PSTK	118672	broad.mit.edu	37	10	124739930	124739930	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:124739930G>A	uc001lgy.1	+	1	375	c.-65G>A	c.(-67--63)GCGTG>GCATG			NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase								ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GACGCTGCGCGTGCGCGCAGG	0.692		NaN									OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	3									
UROS	7390	broad.mit.edu	37	10	127486691	127486691	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:127486691G>A	uc001liw.3	-	6	551	c.418C>T	c.(418-420)CTA>TTA	p.L140L	UROS_uc001liv.3_Silent_p.F19F|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Silent_p.L140L|UROS_uc001liy.3_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	140					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				CAGGGAAATAGAAGAGGCAGT	0.507		NaN											0	0	0	1	0	25	40									
EBF3	253738	broad.mit.edu	37	10	131760444	131760444	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:131760444C>T	uc001lki.1	-	4	461	c.402G>A	c.(400-402)ATG>ATA	p.M134I	EBF3_uc010qur.1_3'UTR	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	134					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCTGTTTGGTCATTGAATCTA	0.488		NaN											0	0	0	1	0	16	35									
HIPK3	10114	broad.mit.edu	37	11	33308756	33308756	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:33308756C>T	uc001mul.1	+	2	1066	c.796C>T	c.(796-798)CAG>TAG	p.Q266*	HIPK3_uc001mum.1_Nonsense_Mutation_p.Q266*|HIPK3_uc009yjv.1_Nonsense_Mutation_p.Q266*	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	266	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TGAATGCTTTCAGCACCGTAA	0.368		NaN											0	0	0	1	0	6	87									
C11orf41	25758	broad.mit.edu	37	11	33605015	33605015	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:33605015G>C	uc001mup.3	+	10	3785	c.3661G>C	c.(3661-3663)GAC>CAC	p.D1221H	C11orf41_uc001mun.1_Missense_Mutation_p.D1221H	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1215						integral to membrane				ovary(2)	2						CTTCAAGCCTGACACCATGAT	0.567		NaN											0	0	0	1	0	2	0									
PAMR1	25891	broad.mit.edu	37	11	35492234	35492234	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:35492234G>A	uc001mwg.2	-	5	670	c.627C>T	c.(625-627)AGC>AGT	p.S209S	PAMR1_uc001mwf.2_Silent_p.S209S|PAMR1_uc010rew.1_Intron|PAMR1_uc010rex.1_Silent_p.S169S	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	209	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGGATCCTATGCTCTGGATAG	0.522		NaN											0	0	0	1	0	15	14									
TNKS1BP1	85456	broad.mit.edu	37	11	57076110	57076110	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:57076110G>A	uc001njr.2	-	5	4387	c.4075C>T	c.(4075-4077)CCA>TCA	p.P1359S	TNKS1BP1_uc001njs.2_Missense_Mutation_p.P1359S|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.P810S	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1359	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GCTTCACTTGGAGCCCCAAAG	0.652		NaN											0	0	0	1	0	48	104									
RAB3IL1	5866	broad.mit.edu	37	11	61672126	61672126	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:61672126G>A	uc001nso.2	-	7	949	c.791C>T	c.(790-792)TCG>TTG	p.S264L	RAB3IL1_uc001nsp.2_Missense_Mutation_p.S238L	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	264							protein binding			skin(2)|central_nervous_system(1)	3						TACCAGCACCGAGAGCTGTGG	0.692		NaN											0	0	0	1	0	3	10									
TUT1	64852	broad.mit.edu	37	11	62342673	62342673	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:62342673C>T	uc001nto.2	-	9	2670	c.2632G>A	c.(2632-2634)GAC>AAC	p.D878N	EEF1G_uc001ntm.1_5'Flank|EEF1G_uc010rlw.1_5'Flank|EEF1G_uc001ntn.1_5'Flank|TUT1_uc001ntp.1_Missense_Mutation_p.D374N	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	840					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						AGCATTCGGTCAGCCGGGGAG	0.567		NaN											0	0	0	1	0	28	46									
ATL3	25923	broad.mit.edu	37	11	63398817	63398817	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:63398817G>C	uc001nxk.1	-	12	1510	c.1234C>G	c.(1234-1236)CGT>GGT	p.R412G	ATL3_uc010rms.1_Missense_Mutation_p.R394G|ATL3_uc010rmr.1_Missense_Mutation_p.R70G	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	atlastin 3	412	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			pancreas(1)	1						TGCTGGTAACGAAAGCTGAAA	0.463		NaN											0	0	0	1	0	39	60									
CCDC88B	283234	broad.mit.edu	37	11	64119604	64119604	+	Silent	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:64119604C>G	uc001nzy.2	+	19	3146	c.3102C>G	c.(3100-3102)GCC>GCG	p.A1034A	CCDC88B_uc009ypo.1_Silent_p.A1031A|CCDC88B_uc001oaa.2_Silent_p.A186A|CCDC88B_uc001oab.1_5'Flank|CCDC88B_uc001oac.2_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1034	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						CATCCTAGGCCGAGAAGTCTG	0.667		NaN											0	0	0	1	0	16	20									
CARNS1	57571	broad.mit.edu	37	11	67190990	67190990	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:67190990G>C	uc009yrp.2	+	9	1854	c.1402G>C	c.(1402-1404)GAT>CAT	p.D468H	PPP1CA_uc001okx.1_5'Flank|CARNS1_uc001olc.3_Missense_Mutation_p.D607H	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	468					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						CCTCAAGCTAGATGGCTGCTT	0.627		NaN											0	0	0	1	0	10	15									
SHANK2	22941	broad.mit.edu	37	11	70349010	70349010	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:70349010G>A	uc001oqc.2	-	15	2166	c.2088C>T	c.(2086-2088)GTC>GTT	p.V696V	SHANK2_uc010rqn.1_Silent_p.V108V|SHANK2_uc001opz.2_Silent_p.V108V|uc009ysn.1_Intron|SHANK2_uc010rqp.1_Silent_p.V108V|SHANK2_uc001opy.2_5'Flank|SHANK2_uc010rqo.1_5'Flank	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	317	PDZ.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GCCTGTGGCCGACTTTGACAA	0.582		NaN											0	0	0	1	0	8	59									
DHCR7	1717	broad.mit.edu	37	11	71152464	71152464	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:71152464G>A	uc001oqk.2	-	6	685	c.435C>T	c.(433-435)ATC>ATT	p.I145I	DHCR7_uc001oql.2_Silent_p.I145I	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	145			I -> L (in SLOS).		cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	GCAGGCCATTGATCTGATACT	0.552		NaN							Smith-Lemli-Opitz_syndrome				0	0	0	1	0	17	18									
MAP6	4135	broad.mit.edu	37	11	75298823	75298823	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:75298823G>A	uc001owu.2	-	4	1788	c.1723C>T	c.(1723-1725)CCT>TCT	p.P575S		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	575	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GGGACCATAGGAGCTTGATTC	0.502		NaN											0	0	0	1	0	59	100									
CARD16	114769	broad.mit.edu	37	11	104912200	104912200	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:104912200T>C	uc001pip.1	-	3	548	c.521A>G	c.(520-522)CAT>CGT	p.H174R	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_3'UTR	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	174					regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						AGATCCTTTATGCAAGGGGAG	0.383		NaN											0	0	0	1	0	32	53									
ALKBH8	91801	broad.mit.edu	37	11	107427575	107427575	+	Missense_Mutation	SNP	C	C	T	rs150490382		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:107427575C>T	uc010rvr.1	-	3	359	c.284G>A	c.(283-285)AGA>AAA	p.R95K	ALKBH8_uc010rvq.1_5'UTR|ALKBH8_uc009yxp.2_Missense_Mutation_p.R95K|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	95	RRM.				response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		AACATAGGCTCTCTTAGATTC	0.378		NaN											0	0	0	1	0	20	32									
C11orf65	160140	broad.mit.edu	37	11	108277655	108277655	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:108277655A>G	uc001pkh.2	-	5	334	c.264T>C	c.(262-264)TTT>TTC	p.F88F	C11orf65_uc010rvx.1_Silent_p.F39F|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	88										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		GTCTGTGAGTAAAAATCTTAT	0.313		NaN											0	0	0	1	0	25	32									
DIXDC1	85458	broad.mit.edu	37	11	111853158	111853158	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:111853158G>A	uc001pml.2	+	8	1162	c.865G>A	c.(865-867)GAA>AAA	p.E289K	DIXDC1_uc001pmm.2_Missense_Mutation_p.E78K|DIXDC1_uc001pmn.2_5'UTR	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	289	Potential.|Actin-binding.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GGAACAACAAGAATATTTAGA	0.423		NaN									OREG0021331	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	8	13									
CDON	50937	broad.mit.edu	37	11	125848278	125848278	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:125848278C>T	uc009zbw.2	-	18	3405	c.3277G>A	c.(3277-3279)GGT>AGT	p.G1093S	CDON_uc001qdb.3_Missense_Mutation_p.G470S|CDON_uc001qdc.3_Missense_Mutation_p.G1093S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	1093	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ATTCCACCACCCTGGACAGGA	0.443		NaN											0	0	0	1	0	4	10									
KCNJ1	3758	broad.mit.edu	37	11	128709869	128709869	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:128709869G>A	uc001qeo.1	-	2	378	c.327C>T	c.(325-327)CTC>CTT	p.L109L	KCNJ1_uc001qep.1_Silent_p.L90L|KCNJ1_uc001qeq.1_Silent_p.L90L|KCNJ1_uc001qer.1_Silent_p.L90L|KCNJ1_uc001qes.1_Silent_p.L90L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	109	Extracellular (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	GGAATTCCGGGAGGTCTTTGT	0.448		NaN											0	0	0	1	0	42	68									
ST14	6768	broad.mit.edu	37	11	130066285	130066285	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:130066285G>T	uc001qfw.2	+	10	1358	c.1165G>T	c.(1165-1167)GAG>TAG	p.E389*	ST14_uc010sca.1_Nonsense_Mutation_p.E199*	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	389	CUB 2.|Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CTACCTGCTGGAGCCCGGCGT	0.637		NaN											1	0	1.23904e-05	1	1.25394e-05	4	11									
NRIP2	83714	broad.mit.edu	37	12	2944131	2944131	+	Missense_Mutation	SNP	G	G	C	rs146664830		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:2944131G>C	uc001qlc.2	-	1	91	c.19C>G	c.(19-21)CTT>GTT	p.L7V	NRIP2_uc010sed.1_Missense_Mutation_p.L7V|uc009zdz.1_5'Flank	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	7					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGGAGGGAAAGAGGAAAAATA	0.562		NaN											0	0	0	1	0	15	23									
VWF	7450	broad.mit.edu	37	12	6161924	6161924	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:6161924C>T	uc001qnn.1	-	16	2221	c.1971G>A	c.(1969-1971)GTG>GTA	p.V657V	VWF_uc010set.1_Silent_p.V657V	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	657	TIL 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	ACTGCAGGTACACCTGGCCTT	0.597		NaN											0	0	0	1	0	11	26									
C1RL	51279	broad.mit.edu	37	12	7254567	7254567	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:7254567G>A	uc001qsn.2	-	3	434	c.417C>T	c.(415-417)TTC>TTT	p.F139F	C1RL_uc009zft.2_Silent_p.F139F|C1RL_uc001qso.1_Silent_p.F139F	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	139	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						GCTGTGTGCGGAAGGTCAGCC	0.627		NaN											0	0	0	1	0	50	76									
DUSP16	80824	broad.mit.edu	37	12	12630261	12630261	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:12630261G>C	uc001rao.1	-	7	2136	c.1504C>G	c.(1504-1506)CCA>GCA	p.P502A	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.P354A	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	502					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CGATGCAGTGGAGATAAAAGG	0.587		NaN											0	0	0	1	0	37	58									
PDE3A	5139	broad.mit.edu	37	12	20523043	20523043	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:20523043G>A	uc001reh.1	+	1	847	c.825G>A	c.(823-825)CTG>CTA	p.L275L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627		NaN											0	0	0	1	0	17	29									
OVCH1	341350	broad.mit.edu	37	12	29639199	29639199	+	Silent	SNP	T	T	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:29639199T>G	uc001rix.1	-	8	975	c.975A>C	c.(973-975)GGA>GGC	p.G325G		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	325	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CTCTCTGGCTTCCATTCACTT	0.443		NaN											0	0	0	1	0	21	31									
CAPRIN2	65981	broad.mit.edu	37	12	30881858	30881858	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:30881858C>T	uc001rji.1	-	8	2257	c.1506G>A	c.(1504-1506)CAG>CAA	p.Q502Q	CAPRIN2_uc001rjf.1_Silent_p.Q299Q|CAPRIN2_uc001rjg.1_Silent_p.Q169Q|CAPRIN2_uc001rjh.1_Silent_p.Q502Q|CAPRIN2_uc001rjj.1_Silent_p.Q169Q|CAPRIN2_uc001rjk.3_Silent_p.Q502Q|CAPRIN2_uc001rjl.3_Silent_p.Q502Q|CAPRIN2_uc001rjm.1_Silent_p.Q169Q|CAPRIN2_uc001rjn.1_Silent_p.Q169Q	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	502					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CTTGTTCTTTCTGCAGCTGAA	0.473		NaN											0	0	0	1	0	55	75									
ARID2	196528	broad.mit.edu	37	12	46244139	46244139	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:46244139C>T	uc001ros.1	+	15	2233	c.2233C>T	c.(2233-2235)CAG>TAG	p.Q745*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q745*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q201*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q372*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q79*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	745					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCTGTTGTTCAGAATCATAG	0.443		NaN											0	0	0	1	0	41	51									
RND1	27289	broad.mit.edu	37	12	49255809	49255809	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:49255809C>T	uc001rsn.2	-	3	404	c.301G>A	c.(301-303)GAC>AAC	p.D101N		NM_014470	NP_055285	Q92730	RND1_HUMAN	GTP-binding protein RHO6 precursor	101					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			ovary(1)	1						AGTGCGCTGTCCACTGTCTCT	0.448		NaN											0	0	0	1	0	24	28									
PRPF40B	25766	broad.mit.edu	37	12	50036434	50036434	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:50036434C>T	uc001rur.1	+	20	2092	c.2028C>T	c.(2026-2028)TTC>TTT	p.F676F	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Silent_p.F698F|PRPF40B_uc001ruq.1_Silent_p.F663F|PRPF40B_uc001rus.1_Silent_p.F619F|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	676					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						TCCGGCTCTTCCGGGAGTTCC	0.567		NaN											0	0	0	1	0	16	22									
RARG	5916	broad.mit.edu	37	12	53607432	53607432	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:53607432G>A	uc001sce.2	-	8	1351	c.866C>T	c.(865-867)TCC>TTC	p.S289F	RARG_uc001scd.2_Missense_Mutation_p.S278F|RARG_uc010sob.1_Missense_Mutation_p.S267F|RARG_uc001scf.2_Missense_Mutation_p.S289F|RARG_uc001scg.2_Missense_Mutation_p.S217F|RARG_uc010soc.1_Missense_Mutation_p.S168F|RARG_uc010sod.1_Missense_Mutation_p.S326F	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	289	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CAGCCCGTCGGAGAAGGTCAT	0.622		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	38									
RARG	5916	broad.mit.edu	37	12	53607867	53607867	+	Silent	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:53607867G>C	uc001sce.2	-	7	1274	c.789C>G	c.(787-789)CTC>CTG	p.L263L	RARG_uc001scd.2_Silent_p.L252L|RARG_uc010sob.1_Silent_p.L241L|RARG_uc001scf.2_Silent_p.L263L|RARG_uc001scg.2_Silent_p.L191L|RARG_uc010soc.1_Silent_p.L142L|RARG_uc010sod.1_Silent_p.L300L	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	263	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AGGCAGCTTTGAGCAGAGTGA	0.532		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	66	136									
SMUG1	23583	broad.mit.edu	37	12	54576210	54576210	+	Silent	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:54576210G>C	uc001sff.1	-	4	612	c.483C>G	c.(481-483)GTC>GTG	p.V161V	SMUG1_uc001sfa.1_5'Flank|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Silent_p.V161V|SMUG1_uc009znf.1_Silent_p.V161V|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	161				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						ATAGATTGTGGACAAAACAGT	0.562		NaN						BER_DNA_glycosylases					0	0	0	1	0	34	74									
ERBB3	2065	broad.mit.edu	37	12	56490853	56490853	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:56490853G>A	uc001sjh.2	+	20	2492	c.2299G>A	c.(2299-2301)GAC>AAC	p.D767N	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Missense_Mutation_p.D124N|ERBB3_uc010sqc.1_Missense_Mutation_p.D708N|ERBB3_uc009zok.2_Intron|ERBB3_uc001sjk.2_Missense_Mutation_p.D8N	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	767	Cytoplasmic (Potential).|Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TGGCAGCCTGGACCATGCCCA	0.512		NaN											0	0	0	1	0	29	35									
ANKRD52	283373	broad.mit.edu	37	12	56637606	56637606	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:56637606C>T	uc001skm.3	-	27	3033	c.2943G>A	c.(2941-2943)CTG>CTA	p.L981L		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	981	ANK 28.						protein binding			ovary(2)	2						CCCCATGACTCAGCAGGGCCT	0.567		NaN											0	0	0	1	0	4	0									
STAC3	246329	broad.mit.edu	37	12	57637672	57637672	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:57637672C>T	uc001snp.2	-	12	1213	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	STAC3_uc009zpl.2_Missense_Mutation_p.R57Q|STAC3_uc001snq.2_Missense_Mutation_p.E301K|STAC3_uc010srm.1_Missense_Mutation_p.E154K	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	340	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						CCGCCCGCTTCGTCTCCTTTC	0.562		NaN									OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	4	16									
ARHGAP9	64333	broad.mit.edu	37	12	57870952	57870952	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:57870952G>A	uc001sod.2	-	8	1263	c.1070C>T	c.(1069-1071)CCG>CTG	p.P357L	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.P102L|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Missense_Mutation_p.P286L|ARHGAP9_uc001soc.2_Missense_Mutation_p.P286L|ARHGAP9_uc001soe.1_Missense_Mutation_p.P365L|ARHGAP9_uc010sro.1_Missense_Mutation_p.P286L	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	286					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGGGTCAAGCGGTTCTGGGGT	0.522		NaN											0	0	0	1	0	21	41									
GNS	2799	broad.mit.edu	37	12	65130795	65130795	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:65130795G>C	uc001ssg.3	-	9	1257	c.1087C>G	c.(1087-1089)CAG>GAG	p.Q363E	GNS_uc001ssf.2_Missense_Mutation_p.Q307E|GNS_uc010ssq.1_Missense_Mutation_p.Q395E|GNS_uc010ssr.1_Missense_Mutation_p.Q343E	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	363						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		TTGCTTGTCTGATTTGGTTTG	0.453		NaN											0	0	0	1	0	14	27									
ZFC3H1	196441	broad.mit.edu	37	12	72024481	72024481	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:72024481G>C	uc001swo.2	-	18	3982	c.3623C>G	c.(3622-3624)ACA>AGA	p.T1208R		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1208					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TCGGCTAAGTGTATAGTCTTG	0.318		NaN											0	0	0	1	0	14	30									
C12orf26	84190	broad.mit.edu	37	12	82752565	82752565	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:82752565C>T	uc001szq.2	+	1	242	c.221C>T	c.(220-222)TCA>TTA	p.S74L	CCDC59_uc001szp.3_5'Flank	NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	74											0						GCCCTGCCCTCAGAGACGCGC	0.662		NaN									OREG0022008	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	23	38									
UHRF1BP1L	23074	broad.mit.edu	37	12	100452766	100452766	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:100452766C>T	uc001tgq.2	-	14	2518	c.2289G>A	c.(2287-2289)TTG>TTA	p.L763L	UHRF1BP1L_uc001tgp.2_Silent_p.L413L	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	763										ovary(2)	2						TCTTCCGCTTCAATCGGCCAG	0.403		NaN											0	0	0	1	0	47	59									
CHPT1	56994	broad.mit.edu	37	12	102107962	102107962	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:102107962C>T	uc001tin.2	+	2	591	c.368C>T	c.(367-369)TCT>TTT	p.S123F	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.S123F	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	123					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						AGAACAAACTCTTGTTCCCCT	0.378		NaN											0	0	0	1	0	37	95									
CKAP4	10970	broad.mit.edu	37	12	106633728	106633728	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:106633728C>T	uc001tlk.2	-	2	967	c.883G>A	c.(883-885)GAG>AAG	p.E295K		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	295	Potential.					ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						GTCTGTATCTCCTTCACAGCT	0.517		NaN											0	0	0	1	0	35	86									
ALKBH2	121642	broad.mit.edu	37	12	109530580	109530580	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:109530580G>A	uc001tnx.2	-	2	405	c.12C>T	c.(10-12)TTC>TTT	p.F4F	ALKBH2_uc001tny.2_Silent_p.F4F|ALKBH2_uc010sxj.1_Silent_p.F4F|ALKBH2_uc009zvd.2_Silent_p.F4F|ALKBH2_uc010sxk.1_Silent_p.F4F	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	4					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CTTTCACCAGGAATCTGTCCA	0.522		NaN						Direct_reversal_of_damage					0	0	0	1	0	39	83									
ATXN2	6311	broad.mit.edu	37	12	111951193	111951193	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:111951193G>A	uc001tsj.2	-	11	2168	c.2006C>T	c.(2005-2007)TCG>TTG	p.S669L	ATXN2_uc001tsh.2_Missense_Mutation_p.S404L|ATXN2_uc001tsi.2_Missense_Mutation_p.S380L|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Missense_Mutation_p.S404L	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	669	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CGTTCCCCCCGAGGGACTGGT	0.512		NaN											0	0	0	1	0	19	32									
DTX1	1840	broad.mit.edu	37	12	113515257	113515257	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:113515257C>T	uc001tuk.1	+	2	624	c.288C>T	c.(286-288)TTC>TTT	p.F96F		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	96	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GGCGCAACTTCTACGACCCGT	0.672		NaN											0	0	0	1	0	13	26									
VPS37B	79720	broad.mit.edu	37	12	123353041	123353041	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:123353041C>G	uc001udl.2	-	3	455	c.352G>C	c.(352-354)GAG>CAG	p.E118Q		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	118	VPS37 C-terminal.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		GTGTCTTCCTCAATCTTGGCC	0.557		NaN											0	0	0	1	0	4	14									
PIWIL1	9271	broad.mit.edu	37	12	130839176	130839176	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:130839176C>G	uc001uik.2	+	10	1229	c.1139C>G	c.(1138-1140)GCC>GGC	p.A380G	PIWIL1_uc001uij.1_Missense_Mutation_p.A380G	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	380	PAZ.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCAGGGCCTGCCATGCTCATT	0.537		NaN											0	0	0	1	0	36	79									
THSD1	55901	broad.mit.edu	37	13	52952424	52952424	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:52952424C>G	uc001vgo.2	-	5	2226	c.1681G>C	c.(1681-1683)GAC>CAC	p.D561H	THSD1_uc001vgp.2_Missense_Mutation_p.D508H|THSD1_uc010tgz.1_Missense_Mutation_p.D182H|THSD1_uc010aea.2_Missense_Mutation_p.D22H	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	561	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		ATGGCAGTGTCTGTCAGGGGA	0.522		NaN											0	0	0	1	0	72	30									
SLITRK5	26050	broad.mit.edu	37	13	88328436	88328436	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:88328436G>A	uc001vln.2	+	2	1012	c.793G>A	c.(793-795)GAG>AAG	p.E265K	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	265	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TGTAGTTTGTGAGACCCCCTT	0.512		NaN											0	0	0	1	0	38	61									
GPC5	2262	broad.mit.edu	37	13	92345823	92345823	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:92345823C>G	uc010tif.1	+	3	1074	c.708C>G	c.(706-708)ATC>ATG	p.I236M		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	236						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TTGAAGTCATCAACACCACAG	0.532		NaN											0	0	0	1	0	24	40									
DOCK9	23348	broad.mit.edu	37	13	99532219	99532219	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:99532219G>A	uc001vnt.2	-	27	2934	c.2879C>T	c.(2878-2880)TCA>TTA	p.S960L	DOCK9_uc001vnw.2_Missense_Mutation_p.S959L|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.S960L|DOCK9_uc010tis.1_Missense_Mutation_p.S959L|DOCK9_uc010tit.1_Missense_Mutation_p.S960L|DOCK9_uc010afu.1_Missense_Mutation_p.S806L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	960					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GAAAAACCATGAGTACTAAAA	0.239		NaN											0	0	0	1	0	15	29									
ERCC5	2073	broad.mit.edu	37	13	103468829	103468829	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:103468829G>A	uc001vpu.1	+	2	652	c.530G>A	c.(529-531)AGA>AAA	p.R177K	BIVM_uc001vps.2_Missense_Mutation_p.R177K|BIVM_uc010agc.2_5'UTR|BIVM_uc001vpt.2_Missense_Mutation_p.R177K	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	Error:Variant_position_missing_in_P28715_after_alignment					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAAAAGGGAAGATATCAGAAG	0.328		NaN	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	21	30									
MYO16	23026	broad.mit.edu	37	13	109507866	109507866	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:109507866G>A	uc001vqt.1	+	11	1384	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	MYO16_uc010agk.1_Missense_Mutation_p.E442K|MYO16_uc001vqu.1_Missense_Mutation_p.E220K	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	420	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTGCTCTATGAGATTCAGAA	0.478		NaN											0	0	0	1	0	14	13									
CARS2	79587	broad.mit.edu	37	13	111357910	111357910	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:111357910C>T	uc001vrd.2	-	2	273	c.233G>A	c.(232-234)TGT>TAT	p.C78Y	CARS2_uc010tjm.1_Intron	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	78		Zinc (By similarity).			cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	AGTTGGTCCACAGCTATACCT	0.353		NaN											0	0	0	1	0	12	29									
HEATR5A	25938	broad.mit.edu	37	14	31782285	31782285	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:31782285C>T	uc001wrf.3	-	22	3528	c.3451G>A	c.(3451-3453)GAC>AAC	p.D1151N	HEATR5A_uc010ami.2_Missense_Mutation_p.D1049N	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1438							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TAGACTAAGTCAAGCAGTCCA	0.428		NaN											0	0	0	1	0	37	30									
ARHGAP5	394	broad.mit.edu	37	14	32624002	32624002	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:32624002G>A	uc001wrl.2	+	7	4596	c.4357G>A	c.(4357-4359)GAA>AAA	p.E1453K	ARHGAP5_uc001wrm.2_Missense_Mutation_p.E1452K|ARHGAP5_uc001wrn.2_Missense_Mutation_p.E1453K|ARHGAP5_uc001wro.2_Missense_Mutation_p.E192K|ARHGAP5_uc001wrp.2_Missense_Mutation_p.E188K	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1453					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTACAATGGAGAAATTGTAGA	0.418		NaN											0	0	0	1	0	26	11									
C14orf135	64430	broad.mit.edu	37	14	60591527	60591527	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:60591527C>G	uc001xer.3	+	8	2458	c.1936C>G	c.(1936-1938)CTA>GTA	p.L646V	C14orf135_uc001xeq.2_Missense_Mutation_p.L646V|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	880						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		CAAAGCAGTTCTATTAGGATA	0.408		NaN											0	0	0	1	0	67	52									
HIF1A	3091	broad.mit.edu	37	14	62200933	62200933	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:62200933C>T	uc001xfq.2	+	8	1362	c.958C>T	c.(958-960)CAA>TAA	p.Q320*	HIF1A_uc001xfr.2_Nonsense_Mutation_p.Q320*|HIF1A_uc001xfs.2_Nonsense_Mutation_p.Q321*	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	320	Interaction with TSGA10 (By similarity).|PAC.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		GGTTGAAACTCAAGCAACTGT	0.383		NaN											0	0	0	1	0	19	5									
SYNE2	23224	broad.mit.edu	37	14	64453240	64453240	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:64453240G>A	uc001xgm.2	+	19	2448	c.2218G>A	c.(2218-2220)GAA>AAA	p.E740K	SYNE2_uc001xgl.2_Missense_Mutation_p.E740K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	740	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAAAGATGTTGAAAAACTCAT	0.388		NaN											0	0	0	1	0	14	24									
ZFYVE26	23503	broad.mit.edu	37	14	68238913	68238913	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:68238913G>A	uc001xka.2	-	28	5474	c.5335C>T	c.(5335-5337)CAT>TAT	p.H1779Y	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.H1779Y	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1779					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTAGGGGAATGTATACTGGAG	0.428		NaN											0	0	0	1	0	8	3									
ZFYVE1	53349	broad.mit.edu	37	14	73444931	73444931	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:73444931C>T	uc001xnm.2	-	7	2071	c.1431G>A	c.(1429-1431)GAG>GAA	p.E477E	ZFYVE1_uc001xnl.2_Silent_p.E62E|ZFYVE1_uc010arj.2_Silent_p.E477E	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	477						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CCTCGCCTCTCTCATAGCAGG	0.363		NaN											0	0	0	1	0	22	18									
FOS	2353	broad.mit.edu	37	14	75747770	75747770	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:75747770G>T	uc001xrn.2	+	4	991	c.786G>T	c.(784-786)ATG>ATT	p.M262I	FOS_uc010tva.1_Missense_Mutation_p.M226I|FOS_uc010asi.2_Missense_Mutation_p.M148I|FOS_uc001xro.2_Missense_Mutation_p.M114I	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene	262					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		TCAGCAGCATGGAGCTGAAGA	0.597		NaN											1	0	3.62531e-18	1	3.80625e-18	37	28									
FLVCR2	55640	broad.mit.edu	37	14	76107307	76107307	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:76107307G>A	uc001xrs.2	+	7	1621	c.1245G>A	c.(1243-1245)ATG>ATA	p.M415I	FLVCR2_uc010tvd.1_Missense_Mutation_p.M210I	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	415	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCTTCTTTATGACTGGCTATC	0.522		NaN											0	0	0	1	0	14	20									
ADCK1	57143	broad.mit.edu	37	14	78325484	78325484	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:78325484G>A	uc001xui.2	+	4	384	c.285G>A	c.(283-285)AAG>AAA	p.K95K	ADCK1_uc010tvo.1_RNA|ADCK1_uc001xuj.2_Intron|ADCK1_uc001xuk.1_5'UTR	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	102						extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		CCTTCATCAAGGTGGGCCAGC	0.617		NaN											0	0	0	1	0	28	27									
PTPN21	11099	broad.mit.edu	37	14	88974366	88974366	+	Splice_Site	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:88974366T>C	uc001xwv.3	-	4	682	c.351_splice	c.e4-1	p.R117_splice	PTPN21_uc010twc.1_Splice_Site|PTPN21_uc010atf.1_Splice_Site_p.R117_splice	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TACTGATACCTATAAAAAATG	0.338		NaN											0	0	0	1	0	10	6									
CCDC88C	440193	broad.mit.edu	37	14	91806270	91806270	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:91806270G>A	uc010aty.2	-	7	681	c.582C>T	c.(580-582)CTC>CTT	p.L194L	CCDC88C_uc010twk.1_Silent_p.L158L	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	194					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TCCGCAGGTGGAGCACCATGC	0.662		NaN											0	0	0	1	0	6	2									
EXD1	161829	broad.mit.edu	37	15	41482260	41482260	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:41482260C>T	uc001znk.2	-	9	948	c.757G>A	c.(757-759)GCT>ACT	p.A253T	EXD1_uc001znj.2_Missense_Mutation_p.A51T|EXD1_uc010ucv.1_Missense_Mutation_p.A311T	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	253					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						AGGTAGGTAGCTTCCAGGGCC	0.463		NaN											0	0	0	1	0	37	12									
PLA2G4F	255189	broad.mit.edu	37	15	42434263	42434263	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:42434263G>A	uc001zoz.2	-	20	2532	c.2469C>T	c.(2467-2469)GTC>GTT	p.V823V	PLA2G4F_uc010bcq.2_Silent_p.V120V|PLA2G4F_uc001zoy.2_Silent_p.V455V|PLA2G4F_uc010bcr.2_Silent_p.V574V|PLA2G4F_uc001zpa.2_Silent_p.V574V|PLA2G4F_uc010bcs.2_Silent_p.V610V	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	823	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CGTTGTTCAGGACGTTGTATC	0.597		NaN											0	0	0	1	0	25	13									
SPG11	80208	broad.mit.edu	37	15	44876484	44876484	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:44876484C>G	uc001ztx.2	-	30	5425	c.5394G>C	c.(5392-5394)GAG>GAC	p.E1798D	SPG11_uc010bdw.2_Missense_Mutation_p.E87D|SPG11_uc010ueh.1_Missense_Mutation_p.E1798D|SPG11_uc010uei.1_Missense_Mutation_p.E1798D|SPG11_uc001zty.1_Missense_Mutation_p.E527D	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1798	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AGATCTGCTTCTCCAGCTCCT	0.567		NaN											0	0	0	1	0	16	18									
SNX22	79856	broad.mit.edu	37	15	64445876	64445876	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:64445876G>A	uc002anc.1	+	5	444	c.385G>A	c.(385-387)GAC>AAC	p.D129N	SNX22_uc002amz.1_Missense_Mutation_p.D101N|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	129					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						CCTGCCTGGCGACAGCAGGCA	0.647		NaN									OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	21	16									
DPP8	54878	broad.mit.edu	37	15	65759415	65759415	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:65759415G>A	uc002aov.2	-	13	3309	c.1731C>T	c.(1729-1731)ATC>ATT	p.I577I	DPP8_uc002aow.2_Silent_p.I577I|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Silent_p.I561I|DPP8_uc002aoy.2_Silent_p.I577I|DPP8_uc002aoz.2_Silent_p.I561I|DPP8_uc010bhj.2_Silent_p.I577I|DPP8_uc002apa.2_Silent_p.I474I|DPP8_uc010bhi.2_5'UTR|DPP8_uc010bhk.1_Silent_p.I146I	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	577					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						ATACCTGACTGATGCAGCAAG	0.408		NaN											0	0	0	1	0	12	11									
MYO9A	4649	broad.mit.edu	37	15	72186109	72186109	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:72186109C>T	uc002atl.3	-	26	5526	c.5053G>A	c.(5053-5055)GAA>AAA	p.E1685K	MYO9A_uc002atn.1_Missense_Mutation_p.E1666K|MYO9A_uc002atk.2_Missense_Mutation_p.E409K|MYO9A_uc002atm.1_Missense_Mutation_p.E409K	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1685	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TTTAAGGCTTCTTTGCTGACA	0.378		NaN											0	0	0	1	0	11	10									
CSK	1445	broad.mit.edu	37	15	75091647	75091647	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:75091647G>A	uc010bkb.1	+	6	460	c.277G>A	c.(277-279)GAG>AAG	p.E93K	CSK_uc002ays.2_Missense_Mutation_p.E93K|CSK_uc010bkc.1_5'UTR	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	93	SH2.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						GGAGCAGGCTGAGCGGCTTCT	0.632		NaN											0	0	0	1	0	11	16									
ADAMTS7	11173	broad.mit.edu	37	15	79063930	79063930	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:79063930G>A	uc002bej.3	-	15	2584	c.2373C>T	c.(2371-2373)ATC>ATT	p.I791I	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Silent_p.I791I	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	791	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CAGGCACCTGGATCCAGACAG	0.657		NaN											0	0	0	1	0	7	4									
ACAN	176	broad.mit.edu	37	15	89386642	89386642	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:89386642G>A	uc010upo.1	+	6	1188	c.814G>A	c.(814-816)GAG>AAG	p.E272K	ACAN_uc002bmx.2_Missense_Mutation_p.E272K|ACAN_uc010upp.1_Missense_Mutation_p.E272K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	272					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGCAGCCAATGAGTGCCGGCG	0.642		NaN											0	0	0	1	0	12	11									
C15orf42	90381	broad.mit.edu	37	15	90119460	90119460	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:90119460G>A	uc002boe.2	+	1	643	c.643G>A	c.(643-645)GAA>AAA	p.E215K		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	215					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GGATACCACCGAATGGTCTAA	0.542		NaN											0	0	0	1	0	10	11									
CIB1	10519	broad.mit.edu	37	15	90774617	90774617	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:90774617G>A	uc002bpb.3	-	4	480	c.318C>T	c.(316-318)ATC>ATT	p.I106I	C15orf58_uc002bpc.2_5'Flank	NM_006384	NP_006375	Q99828	CIB1_HUMAN	calcium and integrin binding 1	106	EF-hand 1.				apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			AATGGGACTTGATGTCTGGCG	0.572		NaN											0	0	0	1	0	14	12									
LINS1	55180	broad.mit.edu	37	15	101109805	101109805	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:101109805C>G	uc002bwe.2	-	8	2203	c.1912G>C	c.(1912-1914)GAA>CAA	p.E638Q	LINS1_uc002bwd.2_Missense_Mutation_p.E225Q|LINS1_uc002bwf.2_Missense_Mutation_p.E638Q|LINS1_uc002bwg.2_Missense_Mutation_p.E638Q|LINS1_uc002bwh.2_Missense_Mutation_p.E638Q	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	638											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TCTGTGGATTCCACGTCAGAA	0.493		NaN											0	0	0	1	0	40	24									
SRRM2	23524	broad.mit.edu	37	16	2812478	2812478	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:2812478G>A	uc002crk.2	+	11	2498	c.1949G>A	c.(1948-1950)AGA>AAA	p.R650K	SRRM2_uc002crj.1_Missense_Mutation_p.R554K|SRRM2_uc002crl.1_Missense_Mutation_p.R650K|SRRM2_uc010bsu.1_Missense_Mutation_p.R554K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	650	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCACGCTCTAGAACCCCAGCT	0.612		NaN											0	0	0	1	0	34	51									
ZNF263	10127	broad.mit.edu	37	16	3340089	3340089	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:3340089C>T	uc002cuq.2	+	6	1915	c.1583C>T	c.(1582-1584)TCT>TTT	p.S528F	ZNF263_uc010uww.1_Missense_Mutation_p.S176F|ZNF263_uc002cur.2_Missense_Mutation_p.S176F	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	528	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						AAAAGTTTCTCTCGGAGTTCA	0.507		NaN											0	0	0	1	0	10	34									
ERCC4	2072	broad.mit.edu	37	16	14042169	14042169	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:14042169G>C	uc002dce.2	+	11	2725	c.2716G>C	c.(2716-2718)GCA>CCA	p.A906P	ERCC4_uc010uyz.1_Missense_Mutation_p.A456P	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	906	Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CACCTCTTTTGCAGAAGTCGT	0.448		NaN	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	35	58									
BFAR	51283	broad.mit.edu	37	16	14738279	14738279	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:14738279C>T	uc002dco.2	+	2	357	c.76C>T	c.(76-78)CAG>TAG	p.Q26*	BFAR_uc002dcm.2_Nonsense_Mutation_p.Q26*|BFAR_uc002dcn.2_Nonsense_Mutation_p.Q26*|BFAR_uc002dcp.2_Nonsense_Mutation_p.Q26*|BFAR_uc010uzh.1_5'UTR	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	26	Cytoplasmic (Potential).				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						CACCGGCCCTCAGATTTCTGT	0.493		NaN											0	0	0	1	0	40	63									
C16orf62	57020	broad.mit.edu	37	16	19619564	19619564	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:19619564G>C	uc002dgn.1	+	10	861	c.849G>C	c.(847-849)AAG>AAC	p.K283N	C16orf62_uc002dgo.1_Missense_Mutation_p.K283N|C16orf62_uc002dgp.1_Missense_Mutation_p.K32N|C16orf62_uc010vas.1_Missense_Mutation_p.K157N|C16orf62_uc002dgm.1_Missense_Mutation_p.K283N	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	283						integral to membrane				ovary(1)	1						GGTTTTTCAAGATTGCCTCCA	0.353		NaN											0	0	0	1	0	23	52									
LOC81691	81691	broad.mit.edu	37	16	20837242	20837242	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:20837242G>A	uc002dhv.2	+	8	1056	c.793G>A	c.(793-795)GAA>AAA	p.E265K	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Missense_Mutation_p.E265K|LOC81691_uc002dhw.2_Missense_Mutation_p.E8K|LOC81691_uc002dhy.3_Missense_Mutation_p.E265K	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	265	Exonuclease.					nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						GGTCAAACCTGAAAACAAGAT	0.473		NaN											0	0	0	1	0	5	13									
CRYM	1428	broad.mit.edu	37	16	21272618	21272618	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:21272618C>T	uc002dik.2	-	7	922	c.837G>A	c.(835-837)GTG>GTA	p.V279V	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Silent_p.V237V|CRYM_uc002dim.2_Silent_p.V279V	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	279					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	GGGCTGGTTTCACTCCCTTAA	0.517		NaN											0	0	0	1	0	14	26									
OTOA	146183	broad.mit.edu	37	16	21721355	21721355	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:21721355C>T	uc002djh.2	+	12	1252	c.1251C>T	c.(1249-1251)CTC>CTT	p.L417L	uc002diq.3_Intron|OTOA_uc010vbj.1_Silent_p.L338L|OTOA_uc002dji.2_Silent_p.L93L|OTOA_uc010vbk.1_Silent_p.L65L	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	431					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TCTCCACCCTCAACCAGGTCT	0.517		NaN											0	0	0	1	0	13	23									
HS3ST2	9956	broad.mit.edu	37	16	22826363	22826363	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:22826363C>T	uc002dli.2	+	1	504	c.432C>T	c.(430-432)GGC>GGT	p.G144G	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	144	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		GGGCCTTGGGCACGGAACCCC	0.647		NaN											0	0	0	1	0	10	16									
COG7	91949	broad.mit.edu	37	16	23400346	23400346	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:23400346G>A	uc002dlo.2	-	17	2396	c.2208C>T	c.(2206-2208)ATC>ATT	p.I736I		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	736					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		GTAGCGTCACGATGTGCTGGA	0.617		NaN											0	0	0	1	0	16	17									
KIAA0556	23247	broad.mit.edu	37	16	27751476	27751476	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:27751476G>A	uc002dow.2	+	15	1882	c.1858G>A	c.(1858-1860)GAC>AAC	p.D620N		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	620	Potential.									ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CATCCTGGTTGACCAGAAGAA	0.527		NaN											0	0	0	1	0	27	66									
TUFM	7284	broad.mit.edu	37	16	28857543	28857543	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:28857543G>A	uc002drh.2	-	1	187	c.48C>T	c.(46-48)TTC>TTT	p.F16F	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	13						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						ACTCACCGCTGAAGTGGGGCG	0.687		NaN											0	0	0	1	0	3	6									
INO80E	283899	broad.mit.edu	37	16	30012320	30012320	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:30012320C>T	uc002dvg.1	+	5	456	c.355C>T	c.(355-357)CCC>TCC	p.P119S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvh.1_RNA|INO80E_uc002dvi.1_Missense_Mutation_p.P119S|INO80E_uc002dvj.1_RNA|INO80E_uc002dvk.1_Missense_Mutation_p.P119S	NM_173618	NP_775889	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	119	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				skin(1)	1						AACAGGGTTTCCCCTTCAGGC	0.637		NaN											0	0	0	1	0	10	21									
DCTPP1	79077	broad.mit.edu	37	16	30440456	30440456	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:30440456C>T	uc002dyf.2	-	2	206	c.134G>A	c.(133-135)CGA>CAA	p.R45Q	ZNF771_uc010bzx.2_RNA	NM_024096	NP_077001	Q9H773	DCTP1_HUMAN	dCTP pyrophosphatase 1	45	EAR.				nucleoside triphosphate catabolic process	cytosol	dCTP diphosphatase activity|identical protein binding|magnesium ion binding				0						TTCCCAGTCTCGTTCCGCAGC	0.483		NaN											0	0	0	1	0	21	53									
ADCY7	113	broad.mit.edu	37	16	50335123	50335123	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:50335123C>T	uc002egd.1	+	9	1634	c.1366C>T	c.(1366-1368)CGG>TGG	p.R456W	ADCY7_uc002egb.1_Missense_Mutation_p.R456W|ADCY7_uc002egc.1_Missense_Mutation_p.R456W	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	456	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CATCGACCCCCGGGTACGAGG	0.682		NaN											0	0	0	1	0	4	5									
CHD9	80205	broad.mit.edu	37	16	53301296	53301296	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:53301296G>A	uc002ehb.2	+	20	4575	c.4411G>A	c.(4411-4413)GAA>AAA	p.E1471K	CHD9_uc002egy.2_Missense_Mutation_p.E1471K|CHD9_uc002ehc.2_Missense_Mutation_p.E1471K|CHD9_uc002ehf.2_Missense_Mutation_p.E585K|CHD9_uc010cbw.2_5'UTR|CHD9_uc002ehd.2_Missense_Mutation_p.E997K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1471					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ATCTGAAGCTGAAAGTGAAGG	0.413		NaN											0	0	0	1	0	27	34									
CNOT1	23019	broad.mit.edu	37	16	58621779	58621779	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:58621779G>A	uc002env.2	-	4	507	c.214C>T	c.(214-216)CAG>TAG	p.Q72*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.Q72*|CNOT1_uc002enx.2_Nonsense_Mutation_p.Q72*|CNOT1_uc002enz.1_5'UTR	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	72					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATCAGAAACTGAGTCTTTAAA	0.353		NaN											0	0	0	1	0	20	35									
SLC9A5	6553	broad.mit.edu	37	16	67291253	67291253	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:67291253G>C	uc002esm.2	+	8	1404	c.1341G>C	c.(1339-1341)TTG>TTC	p.L447F	SLC9A5_uc010cee.2_Missense_Mutation_p.L152F|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	447	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CATAGGGCTTGACCATCAAGC	0.542		NaN											0	0	0	1	0	16	54									
ACD	65057	broad.mit.edu	37	16	67694244	67694244	+	Silent	SNP	A	A	G	rs2303761		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:67694244A>G	uc002etq.3	-	1	475	c.138T>C	c.(136-138)CGT>CGC	p.R46R	ACD_uc002etp.3_Silent_p.R46R|ACD_uc002etr.3_Silent_p.R46R|ACD_uc010vjt.1_Silent_p.R36R|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	46					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GGCCCCGCCCACGTACACCCC	0.736		NaN											0	0	0	1	0	6	12									
C16orf86	388284	broad.mit.edu	37	16	67702120	67702120	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:67702120C>T	uc002ety.2	+	4	728	c.571C>T	c.(571-573)CGG>TGG	p.R191W	C16orf48_uc002etw.1_5'Flank|C16orf48_uc010cem.1_5'Flank|C16orf86_uc002etx.1_3'UTR|C16orf86_uc002etz.2_RNA	NM_001012984	NP_001013002	Q6ZW13	CP086_HUMAN	hypothetical protein LOC388284	191											0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCAGCGCCTGCGGCCGCTGTA	0.657		NaN									OREG0023886	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	9	10									
TERF2	7014	broad.mit.edu	37	16	69419340	69419340	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:69419340C>T	uc002exd.2	-	2	428	c.303G>A	c.(301-303)CTG>CTA	p.L101L	TERF2_uc002exe.2_Silent_p.L101L	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	101	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				GCATAACCCGCAGCAATCGGG	0.532		NaN											0	0	0	1	0	20	42									
CYB5B	80777	broad.mit.edu	37	16	69458758	69458758	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:69458758G>A	uc002exg.1	+	1	261	c.172G>A	c.(172-174)GAG>AAG	p.E58K	CYB5B_uc002exf.2_Missense_Mutation_p.E58K|CYB5B_uc010cfl.1_Missense_Mutation_p.E58K	NM_030579	NP_085056	O43169	CYB5B_HUMAN	cytochrome b5 outer mitochondrial membrane	54	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding				0		Ovarian(137;0.101)				CTTCCTCAACGAGGTGGGGCC	0.602		NaN											0	0	0	1	0	15	29									
NFAT5	10725	broad.mit.edu	37	16	69687308	69687308	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:69687308C>T	uc002exm.1	+	4	2136	c.928C>T	c.(928-930)CAG>TAG	p.Q310*	NFAT5_uc002exh.1_Nonsense_Mutation_p.Q104*|NFAT5_uc002exi.2_Nonsense_Mutation_p.Q234*|NFAT5_uc002exj.1_Nonsense_Mutation_p.Q234*|NFAT5_uc002exk.1_Nonsense_Mutation_p.Q234*|NFAT5_uc002exl.1_Nonsense_Mutation_p.Q328*|NFAT5_uc002exn.1_Nonsense_Mutation_p.Q328*	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	310	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGATAGAACACAGCAAGGCTT	0.398		NaN											0	0	0	1	0	14	37									
KIAA0174	9798	broad.mit.edu	37	16	71961660	71961660	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:71961660G>C	uc002fbj.1	+	12	1367	c.1084G>C	c.(1084-1086)GAC>CAC	p.D362H	KIAA0174_uc010cgh.1_Missense_Mutation_p.D362H|KIAA0174_uc002fbk.1_Missense_Mutation_p.K347N|KIAA0174_uc002fbm.1_Missense_Mutation_p.D349H|KIAA0174_uc002fbl.1_Missense_Mutation_p.D318H|KIAA0174_uc002fbn.1_Missense_Mutation_p.D201H|KIAA0174_uc010cgi.1_Missense_Mutation_p.D120H|KIAA0174_uc010cgj.1_Missense_Mutation_p.D266H|KIAA0174_uc010vml.1_RNA			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	347	Interaction with VTA1.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						AGCATCTGAAGACATTGACTT	0.458		NaN											0	0	0	1	0	67	125									
RFWD3	55159	broad.mit.edu	37	16	74685896	74685896	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:74685896C>T	uc002fda.2	-	3	741	c.643G>A	c.(643-645)GAT>AAT	p.D215N	RFWD3_uc010cgq.2_Missense_Mutation_p.D215N	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	215					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTGTCAGAATCAGAACTACTA	0.478		NaN											0	0	0	1	0	34	61									
CMIP	80790	broad.mit.edu	37	16	81739167	81739167	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:81739167T>C	uc002fgp.2	+	19	2227	c.2155T>C	c.(2155-2157)TGC>CGC	p.C719R	CMIP_uc002fgq.1_Missense_Mutation_p.C625R|CMIP_uc010vnq.1_Missense_Mutation_p.C532R|CMIP_uc002fgr.1_Missense_Mutation_p.C566R	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	685	LRR 3.					cytoplasm|nucleus					0						GCTGAACCTGTGCGAGACCCC	0.637		NaN											0	0	0	1	0	6	9									
CDH15	1013	broad.mit.edu	37	16	89261279	89261279	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:89261279G>A	uc002fmt.2	+	14	2238	c.2161G>A	c.(2161-2163)GCT>ACT	p.A721T		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	721	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGGCTTGGAGGCTGCAGATAG	0.637		NaN											0	0	0	1	0	3	8									
KIAA0664	23277	broad.mit.edu	37	17	2604800	2604800	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:2604800C>T	uc002fuy.1	-	6	731	c.645G>A	c.(643-645)CTG>CTA	p.L215L	KIAA0664_uc002fux.1_Silent_p.L147L	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	215							binding			breast(2)	2						TGAGTACTTTCAGGCACTGCA	0.662		NaN											0	0	0	1	0	10	7									
INCA1	388324	broad.mit.edu	37	17	4892128	4892128	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:4892128C>G	uc002gaj.2	-	7	959	c.507G>C	c.(505-507)GAG>GAC	p.E169D	CAMTA2_uc010cku.1_5'Flank|CAMTA2_uc002gag.1_5'Flank|CAMTA2_uc002gah.1_5'Flank|CAMTA2_uc002gai.1_5'Flank|CAMTA2_uc010vsu.1_5'Flank|INCA1_uc002gak.2_Missense_Mutation_p.E169D|INCA1_uc002gal.2_Missense_Mutation_p.E154D|INCA1_uc002gam.2_Missense_Mutation_p.E154D	NM_213726	NP_998891	Q0VD86	INCA1_HUMAN	inhibitor of CDK, cyclin A1 interacting protein	169						nucleus					0						AGGTTGCTCTCTCCTCTTCCA	0.582		NaN											0	0	0	1	0	19	10									
DHX33	56919	broad.mit.edu	37	17	5372147	5372147	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:5372147C>T	uc002gca.2	-	1	35	c.33G>A	c.(31-33)AAG>AAA	p.K11K	DHX33_uc002gcb.2_5'UTR|DHX33_uc010clf.2_Silent_p.K11K	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	11						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCCGGAATCTCTTGGCCGGCG	0.721		NaN											0	0	0	1	0	2	0									
NLRP1	22861	broad.mit.edu	37	17	5440230	5440230	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:5440230C>A	uc002gci.2	-	8	3456	c.2901G>T	c.(2899-2901)ATG>ATT	p.M967I	NLRP1_uc002gcg.1_Missense_Mutation_p.M967I|NLRP1_uc002gck.2_Missense_Mutation_p.M967I|NLRP1_uc002gcj.2_Intron|NLRP1_uc002gcl.2_Intron|NLRP1_uc002gch.3_Missense_Mutation_p.M967I|NLRP1_uc010clh.2_Missense_Mutation_p.M967I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	967	LRR 6.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GTTCCTGCCTCATCTCATCAC	0.622		NaN											1	0	5.50884e-06	1	5.59432e-06	12	12									
USP43	124739	broad.mit.edu	37	17	9580108	9580108	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:9580108C>T	uc010cod.2	+	5	879	c.879C>T	c.(877-879)TTC>TTT	p.F293F	USP43_uc002gma.3_5'UTR|USP43_uc010vva.1_Silent_p.F293F|USP43_uc010coe.2_Silent_p.F90F	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	293					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCAGCGGTTCCTGCGGGTTG	0.557		NaN											0	0	0	1	0	8	4									
RICH2	9912	broad.mit.edu	37	17	12860053	12860053	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:12860053C>T	uc002gnr.3	+	15	1659	c.1332C>T	c.(1330-1332)TTC>TTT	p.F444F	RICH2_uc010vvk.1_Silent_p.F444F|RICH2_uc010vvl.1_Silent_p.F444F|RICH2_uc002gns.3_Silent_p.F244F|RICH2_uc010vvm.1_Silent_p.F444F|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_Silent_p.F167F	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	444	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CAGACTGGTTCTTCCCTGGGG	0.522		NaN											0	0	0	1	0	8	12									
FAM83G	644815	broad.mit.edu	37	17	18874745	18874745	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:18874745G>A	uc002guw.2	-	6	2566	c.2399C>T	c.(2398-2400)ACG>ATG	p.T800M	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	800								p.T800T(1)		ovary(1)|central_nervous_system(1)	2						GCTACCGCCCGTCCTGGCCTT	0.637		NaN											0	0	0	1	0	42	34									
STAC2	342667	broad.mit.edu	37	17	37381683	37381683	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:37381683C>T	uc002hrs.2	-	1	292	c.73G>A	c.(73-75)GCC>ACC	p.A25T	STAC2_uc010cvt.2_5'UTR	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	25					intracellular signal transduction		metal ion binding			pancreas(1)	1						TCCTGGAGGGCGGAGACGGTC	0.602		NaN											0	0	0	1	0	11	10									
CDK12	51755	broad.mit.edu	37	17	37619354	37619354	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:37619354C>T	uc010cvv.2	+	1	1616	c.1030C>T	c.(1030-1032)CGG>TGG	p.R344W	CDK12_uc010wef.1_Missense_Mutation_p.R344W|CDK12_uc002hrw.3_Missense_Mutation_p.R344W	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	344					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GTCTCTGAGTCGGAGTCCACT	0.552		NaN								TCGA Ovarian(9;0.13)			0	0	0	1	0	18	15									
ERBB2	2064	broad.mit.edu	37	17	37864656	37864656	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:37864656G>A	uc002hso.2	+	3	546	c.308G>A	c.(307-309)CGA>CAA	p.R103Q	ERBB2_uc002hsm.2_Missense_Mutation_p.R73Q|ERBB2_uc010cwa.2_Missense_Mutation_p.R88Q|ERBB2_uc002hsp.2_5'UTR|ERBB2_uc010cwb.2_Missense_Mutation_p.R103Q|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Missense_Mutation_p.R73Q|ERBB2_uc002hsn.1_Missense_Mutation_p.R103Q	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	103	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CGGATTGTGCGAGGCACCCAG	0.612		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	1	0	28	27									
PTRF	284119	broad.mit.edu	37	17	40557078	40557078	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:40557078C>T	uc002hzo.2	-	2	959	c.800G>A	c.(799-801)CGG>CAG	p.R267Q	PTRF_uc010wgi.1_Missense_Mutation_p.R249Q	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	267	Potential.				regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CAGGGTGTGCCGCGTCTTCTC	0.607		NaN											0	0	0	1	0	21	12									
HOXB1	3211	broad.mit.edu	37	17	46607197	46607197	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:46607197G>A	uc002ink.1	-	2	624	c.618C>T	c.(616-618)CTC>CTT	p.L206L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	206	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGTTGGTGCGGAGGCCACTGG	0.607		NaN											0	0	0	1	0	48	33									
SCPEP1	59342	broad.mit.edu	37	17	55083551	55083551	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:55083551G>A	uc002iuv.3	+	13	1367	c.1314G>A	c.(1312-1314)GGG>GGA	p.G438G	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Silent_p.G388G	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	438					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					CTGACCAAGGGGACATGGCTC	0.522		NaN											0	0	0	1	0	25	56									
BZRAP1	9256	broad.mit.edu	37	17	56386419	56386419	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:56386419C>T	uc002ivx.3	-	22	5085	c.4214G>A	c.(4213-4215)CGG>CAG	p.R1405Q	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.R1345Q|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1405Q	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1405						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCTCTCCTCCGGCTGCTTCC	0.642		NaN											0	0	0	1	0	47	58									
RAD51C	5889	broad.mit.edu	37	17	56774148	56774148	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:56774148G>A	uc002iwu.2	+	3	541	c.499G>A	c.(499-501)GAT>AAT	p.D167N	RAD51C_uc010woa.1_Missense_Mutation_p.D167N|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	167					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTTATGGTTGATAGAGTGGT	0.413		NaN						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	1	0	29	47									
GNA13	10672	broad.mit.edu	37	17	63010911	63010911	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:63010911T>C	uc002jfc.2	-	4	807	c.598A>G	c.(598-600)AGA>GGA	p.R200G	GNA13_uc010wqh.1_Missense_Mutation_p.R105G	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	200	GTP (By similarity).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						GTGGGTCTTCTGGCAAGCAGA	0.353		NaN											0	0	0	1	0	26	43									
BPTF	2186	broad.mit.edu	37	17	65908474	65908474	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:65908474G>A	uc002jgf.2	+	11	4535	c.4474G>A	c.(4474-4476)GAT>AAT	p.D1492N	BPTF_uc002jge.2_Missense_Mutation_p.D1618N	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1618					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GAGTTCTTCAGATGCTGAAGG	0.433		NaN											0	0	0	1	0	33	61									
GRIN2C	2905	broad.mit.edu	37	17	72846043	72846043	+	Silent	SNP	G	G	A	rs147077649	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:72846043G>A	uc002jlt.1	-	7	1677	c.1521C>T	c.(1519-1521)ATC>ATT	p.I507I	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.I507I	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	507	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGAGGGAGCCGATGGCCATGT	0.607		NaN											0	0	0	1	0	30	50									
ICT1	3396	broad.mit.edu	37	17	73016475	73016475	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:73016475G>A	uc002jmm.2	+	4	353	c.351G>A	c.(349-351)CAG>CAA	p.Q117Q		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	117					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					CCGTGCGGCAGAAGATAGCCA	0.507		NaN											0	0	0	1	0	20	29									
GALK1	2584	broad.mit.edu	37	17	73754661	73754661	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:73754661G>C	uc010wsi.1	-	6	876	c.813C>G	c.(811-813)AGC>AGG	p.S271R	GALK1_uc002jpk.2_Missense_Mutation_p.S271R	NM_000154	NP_000145	P51570	GALK1_HUMAN	galactokinase 1	271					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGCCCTCTTTGCTCACCAGGT	0.701		NaN											0	0	0	1	0	4	8									
FBF1	85302	broad.mit.edu	37	17	73923539	73923539	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:73923539C>T	uc002jqc.2	-	8	704	c.430G>A	c.(430-432)GAA>AAA	p.E144K	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E134K|FBF1_uc002jqd.1_Missense_Mutation_p.E144K	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	144											0						ATGGTACCTTCAGAGGAAAAC	0.577		NaN											0	0	0	1	0	3	3									
SRP68	6730	broad.mit.edu	37	17	74041408	74041408	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:74041408C>T	uc002jqk.1	-	12	1394	c.1359G>A	c.(1357-1359)GAG>GAA	p.E453E	SRP68_uc010wsu.1_Silent_p.E352E|SRP68_uc002jql.1_Silent_p.E415E|SRP68_uc002jqj.1_Silent_p.E114E	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	453					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TGAGGCCTATCTCTTTCTGGA	0.463		NaN											0	0	0	1	0	30	46									
EXOC7	23265	broad.mit.edu	37	17	74093986	74093986	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:74093986G>A	uc002jqs.2	-	5	626	c.531C>T	c.(529-531)GAC>GAT	p.D177D	EXOC7_uc010dgv.1_Silent_p.D124D|EXOC7_uc002jqq.2_Silent_p.D177D|EXOC7_uc010wsw.1_Silent_p.D177D|EXOC7_uc010wsx.1_Silent_p.D177D|EXOC7_uc002jqr.2_Silent_p.D177D|EXOC7_uc010wsv.1_Silent_p.D136D|EXOC7_uc002jqu.2_Silent_p.D177D	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	177					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			CCAGATCATCGTCACCACTGA	0.617		NaN											0	0	0	1	0	34	77									
RHBDF2	79651	broad.mit.edu	37	17	74474947	74474947	+	Missense_Mutation	SNP	G	G	A	rs138968491		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:74474947G>A	uc002jrq.1	-	6	993	c.700C>T	c.(700-702)CGC>TGC	p.R234C	RHBDF2_uc002jrp.1_Missense_Mutation_p.R205C|RHBDF2_uc002jrr.1_Missense_Mutation_p.R86C|RHBDF2_uc010wtf.1_Missense_Mutation_p.R205C|RHBDF2_uc002jrs.1_Missense_Mutation_p.R229C	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	234	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						CTCTTGCGGCGTGGCAGGTGG	0.687		NaN											0	0	0	1	0	17	28									
TMC6	11322	broad.mit.edu	37	17	76115385	76115385	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:76115385G>A	uc002juj.1	-	13	1930	c.1804C>T	c.(1804-1806)CTG>TTG	p.L602L	TMC6_uc002jui.1_Silent_p.L181L|TMC6_uc010dhf.1_Silent_p.L435L|TMC6_uc002juk.2_Silent_p.L602L|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Silent_p.L602L	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	602	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CACCAGGTCAGAGTCTGCCCA	0.622		NaN							Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	1	0	33	46									
TXNDC2	84203	broad.mit.edu	37	18	9888112	9888112	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:9888112G>A	uc002koi.3	+	2	2085	c.1636G>A	c.(1636-1638)GAA>AAA	p.E546K	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.E479K	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	546	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GGAAAAACTTGAAGCAGTCAT	0.378		NaN											0	0	0	1	0	11	21									
CEP192	55125	broad.mit.edu	37	18	13057683	13057683	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:13057683G>A	uc010xac.1	+	20	4288	c.4208G>A	c.(4207-4209)TGG>TAG	p.W1403*	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Nonsense_Mutation_p.W928*|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Nonsense_Mutation_p.W1144*	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1403										ovary(4)|pancreas(1)	5						ACTGACCGCTGGCTGCAAGTC	0.498		NaN											0	0	0	1	0	14	33									
ZNF521	25925	broad.mit.edu	37	18	22805210	22805210	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:22805210C>T	uc002kvk.2	-	4	2919	c.2672G>A	c.(2671-2673)TGT>TAT	p.C891Y	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.C891Y|ZNF521_uc002kvl.2_Missense_Mutation_p.C671Y	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	891	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGCTGCCCCACAAATGTCGCA	0.522		NaN	T	PAX5	ALL								0	0	0	1	0	41	71									
DSC1	1823	broad.mit.edu	37	18	28714075	28714075	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:28714075C>T	uc002kwn.2	-	13	2157	c.1895G>A	c.(1894-1896)CGT>CAT	p.R632H	DSC1_uc002kwm.2_Missense_Mutation_p.R632H	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	632	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTGCCGTTGACGAAGAATGGC	0.348		NaN											0	0	0	1	0	31	30									
DSG3	1830	broad.mit.edu	37	18	29054237	29054237	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:29054237C>T	uc002kws.2	+	15	2364	c.2255C>T	c.(2254-2256)GCC>GTC	p.A752V	DSG3_uc002kwt.2_Missense_Mutation_p.A34V	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	752	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCGGAGCAGCCACTGGAGTT	0.537		NaN											0	0	0	1	0	41	29									
MAPRE2	10982	broad.mit.edu	37	18	32682030	32682030	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:32682030C>T	uc002kyg.2	+	4	697	c.517C>T	c.(517-519)CGA>TGA	p.R173*	MAPRE2_uc010xcb.1_Nonsense_Mutation_p.R130*|MAPRE2_uc010xcc.1_Nonsense_Mutation_p.R161*|MAPRE2_uc002kyf.2_Nonsense_Mutation_p.R173*|MAPRE2_uc002kyh.2_Nonsense_Mutation_p.R120*|MAPRE2_uc010xcd.1_Nonsense_Mutation_p.R130*	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	173					cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						TGTAGAGGCACGACAAGGGCA	0.453		NaN											0	0	0	1	0	18	14									
KIAA1468	57614	broad.mit.edu	37	18	59888694	59888694	+	Silent	SNP	T	T	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:59888694T>G	uc002lil.2	+	5	1037	c.822T>G	c.(820-822)CTT>CTG	p.L274L	KIAA1468_uc002lik.1_Silent_p.L274L|KIAA1468_uc010xel.1_Silent_p.L274L|KIAA1468_uc002lim.2_5'UTR	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	274	LisH.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				ACTATAAGCTTACATCAATAA	0.294		NaN											0	0	0	1	0	30	17									
MED16	10025	broad.mit.edu	37	19	876999	876999	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:876999G>T	uc002lqd.1	-	9	1686	c.1535C>A	c.(1534-1536)ACG>AAG	p.T512K	MED16_uc010drw.1_Missense_Mutation_p.T337K|MED16_uc002lqe.2_Missense_Mutation_p.T501K|MED16_uc002lqf.2_Missense_Mutation_p.T501K|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Intron|MED16_uc010xfx.1_Missense_Mutation_p.T357K|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	512					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCTGGCGCGTGTACTCCTC	0.697		NaN											1	0	0.00909568	1	0.00912667	4	3									
SLC25A41	284427	broad.mit.edu	37	19	6427193	6427193	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:6427193C>T	uc010dus.2	-	6	947	c.861G>A	c.(859-861)TCG>TCA	p.S287S	KHSRP_uc002mer.3_5'Flank|SLC25A41_uc010dut.2_Silent_p.S149S	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	287	Solcar 3.|Helical; Name=5; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						GCGTCACAGACGACAGACTGA	0.627		NaN											0	0	0	1	0	3	5									
ZNF557	79230	broad.mit.edu	37	19	7075710	7075710	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:7075710G>A	uc002mgb.2	+	4	540	c.55G>A	c.(55-57)GAG>AAG	p.E19K	ZNF557_uc002mga.2_Missense_Mutation_p.E26K|ZNF557_uc002mgc.2_Missense_Mutation_p.E26K	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		AGGACACACAGAGGGCGGAGA	0.522		NaN											0	0	0	1	0	30	16									
CCDC151	115948	broad.mit.edu	37	19	11533473	11533473	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:11533473G>A	uc002mrs.2	-	9	1316	c.1173C>T	c.(1171-1173)CTC>CTT	p.L391L	CCDC151_uc002mrr.2_Silent_p.L326L|CCDC151_uc010dxz.2_Silent_p.L331L	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	391	Potential.									ovary(1)	1						TCTCGCTCTTGAGCGTCTCCA	0.657		NaN											0	0	0	1	0	11	7									
CACNA1A	773	broad.mit.edu	37	19	13411423	13411423	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:13411423C>T	uc010dze.2	-	18	2459	c.2223G>A	c.(2221-2223)CAG>CAA	p.Q741Q	CACNA1A_uc010dzc.2_Silent_p.Q266Q|CACNA1A_uc002mwy.3_Silent_p.Q740Q|CACNA1A_uc010xne.1_Silent_p.Q269Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	741	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTTGGCTTTCTGTAGGGCAA	0.522		NaN											0	0	0	1	0	5	66									
OR7A5	26659	broad.mit.edu	37	19	14938996	14938996	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:14938996C>T	uc002mzw.2	-	1	281	c.58G>A	c.(58-60)GAA>AAA	p.E20K	OR7A5_uc010xoa.1_Missense_Mutation_p.E20K	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						AGTCCAGGTTCTTGTGAAAAT	0.458		NaN											0	0	0	1	0	24	20									
RASAL3	64926	broad.mit.edu	37	19	15562865	15562865	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:15562865C>T	uc002nbe.2	-	17	2969	c.2883G>A	c.(2881-2883)CTG>CTA	p.L961L	WIZ_uc002nbb.3_5'Flank|RASAL3_uc002nbd.2_3'UTR|RASAL3_uc010eaa.1_Intron	NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	961	Potential.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						CCAGGTTTTTCAGACTGTGCC	0.577		NaN											0	0	0	1	0	25	45									
CILP2	148113	broad.mit.edu	37	19	19650526	19650526	+	Missense_Mutation	SNP	G	G	T	rs142743091		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:19650526G>T	uc002nmv.3	+	2	188	c.103G>T	c.(103-105)GGC>TGC	p.G35C	CILP2_uc002nmw.3_Missense_Mutation_p.G35C	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	35						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GACTGCACTGGGCCTGGAAAG	0.667		NaN											1	0	1.42536e-11	1	1.48066e-11	23	62									
ZNF714	148206	broad.mit.edu	37	19	21300833	21300833	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:21300833G>A	uc002npo.3	+	6	1726	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	ZNF714_uc002npl.2_Missense_Mutation_p.E301K|ZNF714_uc010ecp.1_Missense_Mutation_p.E407K|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	456	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACAAATGTGAAGAATGTGG	0.368		NaN											0	0	0	1	0	21	43									
UPK1A	11045	broad.mit.edu	37	19	36159496	36159496	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:36159496C>T	uc002oaw.2	+	2	225	c.225C>T	c.(223-225)TTC>TTT	p.F75F	UPK1A_uc010eeh.2_Silent_p.F75F|uc002oax.1_Missense_Mutation_p.M17I	NM_007000	NP_008931	O00322	UPK1A_HUMAN	uroplakin 1A	75	Helical; (Potential).				epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCCTTCTTCATGGTAGCCA	0.597		NaN											0	0	0	1	0	7	13									
MLL4	9757	broad.mit.edu	37	19	36214671	36214671	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:36214671G>A	uc010eei.2	+	9	3097	c.3097G>A	c.(3097-3099)GAT>AAT	p.D1033N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1033					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGGGATTCCGATGAATCTCC	0.672		NaN											0	0	0	1	0	5	8									
TMEM149	79713	broad.mit.edu	37	19	36231306	36231306	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:36231306C>T	uc002obc.2	-	3	418	c.317G>A	c.(316-318)GGC>GAC	p.G106D	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Missense_Mutation_p.G106D|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.G186D	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	106	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGGGTTCTGCCCCCGCCCGC	0.706		NaN											0	0	0	1	0	5	20									
SUPT5H	6829	broad.mit.edu	37	19	39936594	39936594	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:39936594G>A	uc002olo.3	+	2	243	c.64G>A	c.(64-66)GAG>AAG	p.E22K	SUPT5H_uc010xvb.1_Missense_Mutation_p.E22K|SUPT5H_uc002olp.3_Missense_Mutation_p.E22K|SUPT5H_uc002olq.3_Missense_Mutation_p.E22K|SUPT5H_uc002oln.3_Missense_Mutation_p.E22K|SUPT5H_uc002olr.3_Missense_Mutation_p.E22K	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	22	Glu-rich.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGTGACGGCGAGGAGGCCGA	0.657		NaN											0	0	0	1	0	6	16									
GSK3A	2931	broad.mit.edu	37	19	42744259	42744259	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:42744259G>A	uc002otb.1	-	2	438	c.319C>T	c.(319-321)CTA>TTA	p.L107L	GSK3A_uc002ota.1_Silent_p.L25L|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	107					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				CCTTGGCCTAGAGTGGCTACG	0.587		NaN											0	0	0	1	0	18	40									
MEGF8	1954	broad.mit.edu	37	19	42839208	42839208	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:42839208G>A	uc002otl.3	+	4	1215	c.580G>A	c.(580-582)GAG>AAG	p.E194K	MEGF8_uc002otm.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	194	Extracellular (Potential).|EGF-like 2.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				ATGCCGCTGTGAGCCTGGCTT	0.478		NaN											0	0	0	1	0	9	16									
KLC3	147700	broad.mit.edu	37	19	45852790	45852790	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:45852790G>C	uc002pbf.1	+	8	1188	c.1073G>C	c.(1072-1074)CGG>CCG	p.R358P	KLC3_uc010ejy.1_Missense_Mutation_p.R357P|KLC3_uc002pbg.1_Missense_Mutation_p.R372P	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	358	TPR 4.					cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CACTATGCCCGGGCCCTGAGC	0.637		NaN											0	0	0	1	0	11	60									
ERCC2	2068	broad.mit.edu	37	19	45872219	45872219	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:45872219T>C	uc002pbj.2	-	4	262	c.215A>G	c.(214-216)TAC>TGC	p.Y72C	ERCC2_uc010ejz.2_Missense_Mutation_p.Y72C|ERCC2_uc002pbk.2_Missense_Mutation_p.Y48C|ERCC2_uc002pbl.3_Missense_Mutation_p.Y48C|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	72	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TCTTGAGCAGTAGATGAGTTT	0.577		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	28	50									
CCDC8	83987	broad.mit.edu	37	19	46914757	46914757	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:46914757C>T	uc002pep.2	-	1	2163	c.1311G>A	c.(1309-1311)AGG>AGA	p.R437R		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	437						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CAGCCTCTGCCCTCTGGCCAG	0.612		NaN											0	0	0	1	0	31	53									
SULT2A1	6822	broad.mit.edu	37	19	48374720	48374720	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:48374720A>G	uc002phr.2	-	6	990	c.850T>C	c.(850-852)TGG>CGG	p.W284R		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	284					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		CGTTATTCCCATGGGAACAGC	0.433		NaN											0	0	0	1	0	15	34									
SPHK2	56848	broad.mit.edu	37	19	49132163	49132163	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:49132163C>T	uc002pjr.2	+	7	1464	c.1098C>T	c.(1096-1098)CTC>CTT	p.L366L	SPHK2_uc010xzt.1_Silent_p.L307L|SPHK2_uc002pjs.2_Silent_p.L366L|SPHK2_uc002pjt.2_Silent_p.L160L|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.L330L|SPHK2_uc002pjw.2_Silent_p.L428L	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	366					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TGCTGGGCCTCGCCACACTGC	0.667		NaN											0	0	0	1	0	32	43									
RCN3	57333	broad.mit.edu	37	19	50046469	50046469	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50046469G>A	uc002poj.2	+	7	1433	c.986G>A	c.(985-987)TGA>TAA	p.*329*		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	329						endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GATGAGCTGTGAGCACCGCGC	0.652		NaN											0	0	0	1	0	8	10									
RRAS	6237	broad.mit.edu	37	19	50139972	50139972	+	Silent	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50139972C>A	uc002pop.1	-	4	402	c.357G>T	c.(355-357)GTG>GTT	p.V119V		NM_006270	NP_006261	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	119					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		AGAGCTTGCCCACCTCGTTGA	0.627		NaN											1	0	5.3912e-06	1	5.4938e-06	17	31									
TSKS	60385	broad.mit.edu	37	19	50243401	50243401	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50243401C>T	uc002ppm.2	-	10	1548	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	513							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CTCAGGGCCTCTGCCCTGACG	0.647		NaN											0	0	0	1	0	22	65									
FUZ	80199	broad.mit.edu	37	19	50315567	50315567	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50315567C>T	uc002ppq.1	-	3	364	c.259G>A	c.(259-261)GAG>AAG	p.E87K	FUZ_uc002ppr.1_5'UTR|FUZ_uc002pps.1_Intron|FUZ_uc002ppt.1_Intron|FUZ_uc002ppu.1_Intron|FUZ_uc002ppv.1_Missense_Mutation_p.E37K|FUZ_uc010ybd.1_Missense_Mutation_p.E87K	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	87					cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		ATGCCCACCTCAGATGACAGA	0.423		NaN											0	0	0	1	0	6	28									
SIGLEC5	8778	broad.mit.edu	37	19	52132666	52132666	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:52132666C>T	uc002pxe.2	-	3	784	c.645G>A	c.(643-645)ATG>ATA	p.M215I		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	215	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTGGCGTTTCATCTGACAGG	0.632		NaN											0	0	0	1	0	13	38									
ZNF665	79788	broad.mit.edu	37	19	53668818	53668818	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:53668818G>A	uc010eqm.1	-	4	1025	c.925C>T	c.(925-927)CGA>TGA	p.R309*		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	244	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGAATTCTTCGATGACTTGCA	0.428		NaN											0	0	0	1	0	59	136									
RRM2	6241	broad.mit.edu	37	2	10269168	10269168	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:10269168G>A	uc002rah.2	+	9	1095	c.904G>A	c.(904-906)GAG>AAG	p.E302K		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	302					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		TGGTTCCTAGGAGTTCCTCAC	0.438		NaN											0	0	0	1	0	37	86									
C2orf48	348738	broad.mit.edu	37	2	10350668	10350668	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:10350668C>T	uc002rai.1	+	4	714	c.425C>T	c.(424-426)ACA>ATA	p.T142I		NM_182626	NP_872432	Q96LS8	CB048_HUMAN	hypothetical protein LOC348738	142											0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		CTGGACTCCACACAGGCCTGC	0.567		NaN											0	0	0	1	0	31	61									
LAPTM4A	9741	broad.mit.edu	37	2	20237361	20237361	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:20237361G>C	uc002rdm.2	-	3	755	c.247C>G	c.(247-249)CTT>GTT	p.L83V	LAPTM4A_uc002rdn.2_Missense_Mutation_p.L41V|LAPTM4A_uc010yjx.1_Missense_Mutation_p.L73V	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	83	Helical; (Potential).				transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACGGCAAAAAGAACACAGGCA	0.289		NaN											0	0	0	1	0	13	21									
ITSN2	50618	broad.mit.edu	37	2	24521660	24521660	+	Silent	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:24521660T>C	uc002rfe.2	-	13	1626	c.1368A>G	c.(1366-1368)CGA>CGG	p.R456R	ITSN2_uc002rff.2_Silent_p.R456R|ITSN2_uc002rfg.2_Silent_p.R456R|ITSN2_uc010eyd.2_Silent_p.R481R	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	456	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCGACGTTGTCGTTCAAGTT	0.338		NaN											0	0	0	1	0	25	64									
GPR113	165082	broad.mit.edu	37	2	26533881	26533881	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:26533881G>T	uc002rhe.3	-	11	2715	c.2715C>A	c.(2713-2715)TAC>TAA	p.Y905*	GPR113_uc010yky.1_Nonsense_Mutation_p.Y836*|GPR113_uc002rhb.1_Nonsense_Mutation_p.Y508*|GPR113_uc010eyk.1_Nonsense_Mutation_p.Y706*|GPR113_uc002rhc.1_Nonsense_Mutation_p.Y508*|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	905	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTGAGGTAGGTAGAGCCCCA	0.607		NaN											1	0	1.08611e-07	1	1.11449e-07	12	8									
PPP1CB	5500	broad.mit.edu	37	2	29004678	29004678	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:29004678G>C	uc002rmg.2	+	5	650	c.490G>C	c.(490-492)GTG>CTG	p.V164L	PPP1CB_uc010ymj.1_Missense_Mutation_p.V136L|PPP1CB_uc010ymk.1_Missense_Mutation_p.V136L|PPP1CB_uc010yml.1_Missense_Mutation_p.V136L|PPP1CB_uc002rmh.2_Missense_Mutation_p.V164L|SPDYA_uc002rmi.2_5'Flank	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	164					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGCAGCCATTGTGGATGAGAA	0.313		NaN											0	0	0	1	0	11	38									
FAM179A	165186	broad.mit.edu	37	2	29245089	29245089	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:29245089C>T	uc010ezl.2	+	11	1777	c.1426C>T	c.(1426-1428)CTT>TTT	p.L476F	FAM179A_uc010ymm.1_Missense_Mutation_p.L421F|FAM179A_uc002rmr.3_Missense_Mutation_p.L3F	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	476							binding			ovary(3)|skin(1)	4						GGAGATGGATCTTAGAGCCTG	0.542		NaN											0	0	0	1	0	29	59									
LTBP1	4052	broad.mit.edu	37	2	33589339	33589339	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:33589339G>A	uc002ros.2	+	30	4459	c.4459G>A	c.(4459-4461)GAG>AAG	p.E1487K	LTBP1_uc002rot.2_Missense_Mutation_p.E1161K|LTBP1_uc002rou.2_Missense_Mutation_p.E1160K|LTBP1_uc002rov.2_Missense_Mutation_p.E1107K|LTBP1_uc010ymz.1_Missense_Mutation_p.E1118K|LTBP1_uc010yna.1_Missense_Mutation_p.E1065K|LTBP1_uc010ynb.1_Missense_Mutation_p.E384K	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1486	EGF-like 16; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGTTAATACAGAGGGCTCTTA	0.423		NaN											0	0	0	1	0	24	37									
TTC7A	57217	broad.mit.edu	37	2	47177528	47177528	+	Missense_Mutation	SNP	G	G	A	rs147914967		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:47177528G>A	uc002rvo.2	+	2	579	c.211G>A	c.(211-213)GAG>AAG	p.E71K	TTC7A_uc002rvm.2_Missense_Mutation_p.E37K|TTC7A_uc002rvn.1_5'UTR|TTC7A_uc010fbb.2_Missense_Mutation_p.E71K|TTC7A_uc010fbc.2_5'UTR|TTC7A_uc002rvp.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	71							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GCTGCTGGCTGAGGCCCTCCT	0.502		NaN											0	0	0	1	0	64	96									
ASB3	51130	broad.mit.edu	37	2	53992675	53992675	+	Missense_Mutation	SNP	G	G	C	rs146004165		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:53992675G>C	uc002rxg.1	-	2	170	c.35C>G	c.(34-36)TCT>TGT	p.S12C	ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Missense_Mutation_p.S50C|ASB3_uc010yoo.1_Missense_Mutation_p.S12C|CHAC2_uc002rxk.1_5'Flank|uc002rxj.1_5'Flank	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	12	ANK 1.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCAACTGTAGAGCACGTGTC	0.428		NaN											0	0	0	1	0	37	76									
PNPT1	87178	broad.mit.edu	37	2	55882034	55882034	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:55882034C>T	uc002rzf.2	-	18	1548	c.1495_splice	c.e18+1	p.G499_splice	PNPT1_uc002rzg.2_Splice_Site	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AATTCTTTTACCTGAATCCAT	0.204		NaN											0	0	0	1	0	20	51									
USP34	9736	broad.mit.edu	37	2	61431458	61431458	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:61431458C>T	uc002sbe.2	-	74	9339	c.9317G>A	c.(9316-9318)AGC>AAC	p.S3106N	USP34_uc002sbd.2_Intron	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3106					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCGAATATTGCTTTTCCCTCC	0.408		NaN											0	0	0	1	0	25	42									
PLEK	5341	broad.mit.edu	37	2	68592492	68592492	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:68592492A>G	uc002sen.3	+	1	171	c.9A>G	c.(7-9)CCA>CCG	p.P3P	PLEK_uc010fde.2_Silent_p.P3P	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	3					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GCATGGAACCAAAGCGGATCA	0.597		NaN											0	0	0	1	0	32	47									
ATP6V1B1	525	broad.mit.edu	37	2	71192177	71192177	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:71192177C>T	uc002shj.2	+	14	1555	c.1468C>T	c.(1468-1470)CCG>TCG	p.P490S	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.P473S|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.P448S	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	490					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GAAGCGCATTCCGCAGGCCGT	0.662		NaN									OREG0014686	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	26	37									
TTC31	64427	broad.mit.edu	37	2	74718624	74718624	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:74718624C>T	uc002slt.2	+	8	724	c.701C>T	c.(700-702)TCT>TTT	p.S234F	TTC31_uc002sls.2_Missense_Mutation_p.S163F|TTC31_uc010yrv.1_Missense_Mutation_p.S90F|TTC31_uc002slu.2_Missense_Mutation_p.S90F	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	234							binding				0						CTGGATCTATCTAGCACTTTT	0.542		NaN											0	0	0	1	0	88	183									
IMMT	10989	broad.mit.edu	37	2	86374830	86374830	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:86374830C>T	uc002sqz.3	-	13	1916	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	IMMT_uc002sqy.3_Missense_Mutation_p.E251K|IMMT_uc002srb.3_Missense_Mutation_p.E499K|IMMT_uc002sra.3_Missense_Mutation_p.E509K|IMMT_uc010ytd.1_Missense_Mutation_p.E498K|IMMT_uc010yte.1_Missense_Mutation_p.E463K|IMMT_uc002src.1_Missense_Mutation_p.E246K	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	510	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						CTCACCTGCTCAAATTCAGAC	0.483		NaN											0	0	0	1	0	21	29									
REEP1	65055	broad.mit.edu	37	2	86459890	86459890	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:86459890G>A	uc002srh.3	-	6	597	c.453C>T	c.(451-453)TTC>TTT	p.F151F	REEP1_uc010ytg.1_Silent_p.F130F|REEP1_uc010yth.1_Silent_p.F124F|REEP1_uc010yti.1_Missense_Mutation_p.S73L	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	151					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0						CCTGCATGCTGAAGCTCCGCA	0.667		NaN											0	0	0	1	0	13	18									
EIF2AK3	9451	broad.mit.edu	37	2	88890382	88890382	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:88890382A>G	uc002stc.3	-	5	1158	c.956T>C	c.(955-957)GTT>GCT	p.V319A		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	319	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GAATGCCATAACTTTCCAGTC	0.428		NaN											0	0	0	1	0	33	67									
SNRNP200	23020	broad.mit.edu	37	2	96943981	96943981	+	Silent	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:96943981C>G	uc002svu.2	-	39	5690	c.5604G>C	c.(5602-5604)CTG>CTC	p.L1868L	SNRNP200_uc002svt.2_Silent_p.L478L|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1868	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TCACCTGCCTCAGGAGATTGT	0.552		NaN											0	0	0	1	0	29	57									
ANKRD36	375248	broad.mit.edu	37	2	97779539	97779539	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:97779539C>T	uc010yva.1	+	1	307	c.63C>T	c.(61-63)TTC>TTT	p.F21F	ANKRD36_uc002sxn.2_Silent_p.F21F|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Silent_p.F21F|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21											0						CGGATGGCTTCGCATTTCCCC	0.512		NaN											0	0	0	1	0	21	61									
MRPL30	51263	broad.mit.edu	37	2	99804704	99804704	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:99804704C>T	uc002szu.2	+	3	278	c.116C>T	c.(115-117)TCA>TTA	p.S39L	MRPL30_uc002szl.1_RNA|MRPL30_uc002szr.2_Missense_Mutation_p.S39L|MRPL30_uc002szt.1_Intron|MRPL30_uc002szv.2_Missense_Mutation_p.S39L	NM_145213	NP_660214	Q8TCC3	RM30_HUMAN	RecName: Full=39S ribosomal protein L30, mitochondrial;          Short=L30mt; AltName: Full=MRP-L30; AltName: Full=MRP-L28; Flags: Precursor;	39					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1						TTCACCAGATCAAGAATTCCA	0.279		NaN											0	0	0	1	0	4	8									
REV1	51455	broad.mit.edu	37	2	100019151	100019151	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:100019151T>C	uc002tad.2	-	21	3709	c.3497A>G	c.(3496-3498)AAT>AGT	p.N1166S	REV1_uc002tac.2_Missense_Mutation_p.N1165S	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	1166	Protein interaction domain; mediates interaction with DNA polymerase zeta.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						CTTCACATCATTGAATTCAAC	0.488		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	28	47									
SLC9A4	389015	broad.mit.edu	37	2	103142766	103142766	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:103142766C>T	uc002tbz.3	+	11	2456	c.1999C>T	c.(1999-2001)CAG>TAG	p.Q667*		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	667	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CGGGAATCCTCAGTCTGCAGG	0.443		NaN											0	0	0	1	0	24	44									
RANBP2	5903	broad.mit.edu	37	2	109369565	109369565	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:109369565C>T	uc002tem.3	+	13	1993	c.1867C>T	c.(1867-1869)CCT>TCT	p.P623S		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	623					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GAACAGTATTCCTGAACCTAT	0.308		NaN											0	0	0	1	0	32	74									
DPP10	57628	broad.mit.edu	37	2	116594297	116594297	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:116594297A>G	uc002tla.1	+	24	2614	c.2157A>G	c.(2155-2157)ATA>ATG	p.I719M	DPP10_uc002tlb.1_Missense_Mutation_p.I669M|DPP10_uc002tlc.1_Missense_Mutation_p.I715M|DPP10_uc002tle.2_Missense_Mutation_p.I723M|DPP10_uc002tlf.1_Missense_Mutation_p.I712M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	719	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AAGAAAATATATTAATAATTC	0.333		NaN											0	0	0	1	0	44	62									
TMEM177	80775	broad.mit.edu	37	2	120438762	120438762	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:120438762G>A	uc010flg.1	+	2	806	c.333G>A	c.(331-333)TTG>TTA	p.L111L	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Silent_p.L111L|TMEM177_uc002tmd.2_Silent_p.L111L|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	111						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					CCAGTTTCTTGGGAGACCTAG	0.587		NaN											0	0	0	1	0	86	167									
PTPN4	5775	broad.mit.edu	37	2	120725491	120725491	+	Silent	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:120725491T>C	uc002tmf.1	+	26	3408	c.2637T>C	c.(2635-2637)TAT>TAC	p.Y879Y	PTPN4_uc010flj.1_Silent_p.Y592Y|PTPN4_uc010yyr.1_Silent_p.Y512Y	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	879	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGCCAGTTTATCCACTAGATA	0.373		NaN											0	0	0	1	0	32	78									
ERCC3	2071	broad.mit.edu	37	2	128046431	128046431	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:128046431C>T	uc002toh.1	-	7	927	c.832G>A	c.(832-834)GAG>AAG	p.E278K	ERCC3_uc002toe.1_Missense_Mutation_p.E33K|ERCC3_uc002tof.1_Missense_Mutation_p.E214K|ERCC3_uc002tog.1_Missense_Mutation_p.E214K|ERCC3_uc010flx.1_Missense_Mutation_p.E33K	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	278					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TGGAGTTCCTCAATCATTTCC	0.413		NaN	Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	70	117									
BAZ2B	29994	broad.mit.edu	37	2	160206422	160206422	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:160206422C>T	uc002uao.2	-	28	5012	c.4660G>A	c.(4660-4662)GAA>AAA	p.E1554K	BAZ2B_uc002uap.2_Missense_Mutation_p.E1518K	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTATTCTTTTCAGTCAGCGTT	0.428		NaN											0	0	0	1	0	61	115									
TBR1	10716	broad.mit.edu	37	2	162273101	162273101	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:162273101G>A	uc002ubw.1	+	1	482	c.180G>A	c.(178-180)ACG>ACA	p.T60T	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	60						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GGGGGATGACGAATCAGTCAG	0.498		NaN											0	0	0	1	0	31	60									
COBLL1	22837	broad.mit.edu	37	2	165551902	165551902	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:165551902G>A	uc010zcw.1	-	15	2439	c.2315C>T	c.(2314-2316)TCA>TTA	p.S772L	COBLL1_uc002ucp.2_Missense_Mutation_p.S705L|COBLL1_uc002ucq.2_Missense_Mutation_p.S667L|COBLL1_uc010zcx.1_Missense_Mutation_p.S713L|COBLL1_uc002ucn.2_Missense_Mutation_p.S133L|COBLL1_uc002uco.2_Missense_Mutation_p.S436L	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	743										ovary(2)|pancreas(1)	3						CGGATCTTCTGAATGTATAAT	0.373		NaN											0	0	0	1	0	58	104									
TTN	7273	broad.mit.edu	37	2	179398127	179398127	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:179398127G>A	uc010zfg.1	-	307	95735	c.95511C>T	c.(95509-95511)CTC>CTT	p.L31837L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L25532L|TTN_uc010zfi.1_Silent_p.L25465L|TTN_uc010zfj.1_Silent_p.L25340L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32764							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTAGGCCCGAGGGACAGTG	0.473		NaN											0	0	0	1	0	27	51									
TTN	7273	broad.mit.edu	37	2	179422195	179422195	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:179422195C>G	uc010zfg.1	-	278	80314	c.80090G>C	c.(80089-80091)GGA>GCA	p.G26697A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G20392A|TTN_uc010zfi.1_Missense_Mutation_p.G20325A|TTN_uc010zfj.1_Missense_Mutation_p.G20200A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27624							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCACTGCCTCCATTTGACAC	0.458		NaN											0	0	0	1	0	24	66									
TTN	7273	broad.mit.edu	37	2	179429435	179429435	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:179429435C>G	uc010zfg.1	-	275	73944	c.73720G>C	c.(73720-73722)GAG>CAG	p.E24574Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E18269Q|TTN_uc010zfi.1_Missense_Mutation_p.E18202Q|TTN_uc010zfj.1_Missense_Mutation_p.E18077Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25501							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTCATACTCAAGGCCCTCA	0.418		NaN											0	0	0	1	0	19	30									
ITGAV	3685	broad.mit.edu	37	2	187466860	187466860	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:187466860A>T	uc002upq.2	+	2	574	c.298A>T	c.(298-300)ATT>TTT	p.I100F	ITGAV_uc010frs.2_Missense_Mutation_p.I100F|ITGAV_uc010zfv.1_Missense_Mutation_p.I54F	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	100	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GTGCCAGCCAATTGAATTTGA	0.423		NaN											0	0	0	1	0	17	29									
TMEFF2	23671	broad.mit.edu	37	2	192863864	192863864	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:192863864C>T	uc002utc.2	-	6	1001	c.607G>A	c.(607-609)GAT>AAT	p.D203N		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	203	Kazal-like 2.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			CATGCATTATCATAAGATTTC	0.363		NaN											0	0	0	1	0	29	52									
ALS2	57679	broad.mit.edu	37	2	202631985	202631985	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:202631985G>A	uc002uyo.2	-	3	498	c.142C>T	c.(142-144)CTC>TTC	p.L48F	ALS2_uc002uyp.3_Missense_Mutation_p.L48F|ALS2_uc002uyq.2_Missense_Mutation_p.L48F|ALS2_uc002uyr.2_Missense_Mutation_p.L48F	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	48					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TTCACTCCGAGGGCTGCCTGC	0.488		NaN											0	0	0	1	0	14	31									
MAP2	4133	broad.mit.edu	37	2	210558419	210558419	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:210558419G>C	uc002vde.1	+	7	1773	c.1525G>C	c.(1525-1527)GAT>CAT	p.D509H	MAP2_uc002vdc.1_Missense_Mutation_p.D509H|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D505H	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	509					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGCAGTTACAGATTCAGCCAT	0.428		NaN											0	0	0	1	0	25	26									
SIRPB2	284759	broad.mit.edu	37	20	1458977	1458977	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:1458977C>T	uc002wfg.2	-	3	955	c.727G>A	c.(727-729)GTA>ATA	p.V243I	SIRPB2_uc002wfh.3_Missense_Mutation_p.V145I|SIRPB2_uc010zpr.1_Missense_Mutation_p.V105I	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	243	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0						TGAAACTTTACACAGTAATAG	0.512		NaN											0	0	0	1	0	24	48									
STK35	140901	broad.mit.edu	37	20	2083843	2083843	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:2083843G>A	uc010gak.2	+	2	724	c.724G>A	c.(724-726)GAG>AAG	p.E242K	STK35_uc010zpu.1_Missense_Mutation_p.E109K|STK35_uc002wfw.3_Missense_Mutation_p.E109K	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	242	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CGAGAACGTGGAGCTGGCGCT	0.682		NaN											0	0	0	1	0	5	11									
HSPA12B	116835	broad.mit.edu	37	20	3732653	3732653	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:3732653T>A	uc002wjd.2	+	13	2004	c.1901T>A	c.(1900-1902)CTT>CAT	p.L634H	HSPA12B_uc010zqi.1_Missense_Mutation_p.L633H|HSPA12B_uc002wje.2_Missense_Mutation_p.L547H|HSPA12B_uc010zqj.1_Missense_Mutation_p.L468H	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	634							ATP binding				0						AGCCTCGAGCTTGAGCCCGCC	0.697		NaN											0	0	0	1	0	5	7									
RASSF2	9770	broad.mit.edu	37	20	4768393	4768393	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:4768393C>T	uc002wld.2	-	9	753	c.699G>A	c.(697-699)CAG>CAA	p.Q233Q	RASSF2_uc002wlc.2_Intron|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Silent_p.Q233Q|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	233	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						CCTTCAGCTTCTGTTTCTCTG	0.542		NaN											0	0	0	1	0	16	21									
PLCB1	23236	broad.mit.edu	37	20	8722214	8722214	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:8722214G>C	uc002wnb.2	+	23	2520	c.2517G>C	c.(2515-2517)AAG>AAC	p.K839N	PLCB1_uc010zrb.1_Missense_Mutation_p.K738N|PLCB1_uc002wna.2_Missense_Mutation_p.K839N|PLCB1_uc002wnc.1_Missense_Mutation_p.K738N|PLCB1_uc002wnd.1_Missense_Mutation_p.K416N	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	839					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AAGAAGTAAAGAAAGAGGTGA	0.398		NaN											0	0	0	1	0	5	20									
C20orf3	57136	broad.mit.edu	37	20	24973288	24973288	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:24973288G>C	uc002wty.2	-	1	138	c.37C>G	c.(37-39)CTG>GTG	p.L13V	C20orf3_uc002wtz.2_Missense_Mutation_p.L13V|C20orf3_uc010zsw.1_Missense_Mutation_p.L13V	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	13	Cytoplasmic (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						TGCGGCCGCAGGGGCCGGCGC	0.716		NaN											0	0	0	1	0	4	1									
ACSS1	84532	broad.mit.edu	37	20	25038496	25038496	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:25038496G>A	uc002wub.2	-	1	1121	c.243C>T	c.(241-243)CTC>CTT	p.L81L	ACSS1_uc002wuc.2_Silent_p.L81L|ACSS1_uc010gdc.2_Silent_p.L81L	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	81					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTCCCACACGAGAGTGTCCC	0.657		NaN											0	0	0	1	0	18	31									
C20orf134	170487	broad.mit.edu	37	20	32255571	32255571	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:32255571G>A	uc002wzt.2	+	1	1268	c.268G>A	c.(268-270)GAC>AAC	p.D90N	NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron	NM_001024675	NP_001019846	Q5JWF8	CT134_HUMAN	hypothetical protein LOC170487	90										pancreas(1)	1						CGTGTCCCTGGACTTCGAGGG	0.672		NaN											0	0	0	1	0	14	18									
MYH7B	57644	broad.mit.edu	37	20	33574708	33574708	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:33574708G>A	uc002xbi.1	+	13	1142	c.1050G>A	c.(1048-1050)ATG>ATA	p.M350I		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	308	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TTCTGTCTATGAACCCCTATG	0.567		NaN											0	0	0	1	0	26	33									
SPAG4	6676	broad.mit.edu	37	20	34204137	34204137	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:34204137C>T	uc002xdb.1	+	1	329	c.212C>T	c.(211-213)ACA>ATA	p.T71I	SPAG4_uc010zvi.1_5'UTR	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	71					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GGAGGAACCACATGGGCAGGA	0.741		NaN											0	0	0	1	0	7	10									
CTNNBL1	56259	broad.mit.edu	37	20	36322537	36322537	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:36322537G>A	uc010zvw.1	+	1	104	c.13G>A	c.(13-15)GAA>AAA	p.E5K	CTNNBL1_uc010zvv.1_5'UTR	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	5					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				GGACGTGGGCGAACTTCTGAG	0.662		NaN											0	0	0	1	0	3	6									
CHD6	84181	broad.mit.edu	37	20	40049589	40049589	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:40049589G>T	uc002xka.1	-	31	5864	c.5686C>A	c.(5686-5688)CCC>ACC	p.P1896T		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1896					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTAGTAGTGGGCTCCGTGAGA	0.418		NaN											1	0	3.3946e-10	1	3.50775e-10	39	42									
YWHAB	7529	broad.mit.edu	37	20	43530229	43530229	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:43530229G>A	uc002xmt.2	+	3	337	c.55G>A	c.(55-57)GAG>AAG	p.E19K	YWHAB_uc002xmu.2_Missense_Mutation_p.E19K	NM_003404	NP_003395	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan	19					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			kidney(2)|ovary(1)|breast(1)	4		Myeloproliferative disorder(115;0.0122)				TGAGCAGGCTGAGCGATATGA	0.458		NaN											0	0	0	1	0	23	24									
PCIF1	63935	broad.mit.edu	37	20	44573628	44573628	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:44573628G>A	uc002xqs.2	+	11	1441	c.1127G>A	c.(1126-1128)CGA>CAA	p.R376Q	PCIF1_uc002xqt.2_5'UTR|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	376						nucleus				skin(1)	1						AAACGGATCCGAGAGAAGCAC	0.562		NaN											0	0	0	1	0	13	4									
GCFC1	94104	broad.mit.edu	37	21	34120941	34120941	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:34120941T>C	uc002yqn.2	-	11	1982	c.1792A>G	c.(1792-1794)ATT>GTT	p.I598V	GCFC1_uc002yql.2_Missense_Mutation_p.I107V|GCFC1_uc002yqm.2_Missense_Mutation_p.I92V|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.I598V	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	598						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TGTGATTTAATACAGTCAATT	0.358		NaN											0	0	0	1	0	50	16									
CRYZL1	9946	broad.mit.edu	37	21	34962153	34962153	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:34962153C>G	uc011adw.1	-	13	1205	c.1025G>C	c.(1024-1026)AGA>ACA	p.R342T	DONSON_uc002ysn.1_Intron|DONSON_uc002ysj.2_5'Flank|DONSON_uc002ysk.2_5'Flank|DONSON_uc002ysl.2_5'Flank|DONSON_uc010gme.2_5'Flank|DONSON_uc002ysm.2_5'UTR	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	342					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						TTGCTTTTTTCTTCCTTGATT	0.353		NaN											0	0	0	1	0	24	12									
RSPH1	89765	broad.mit.edu	37	21	43913146	43913146	+	Missense_Mutation	SNP	C	C	T	rs145742147	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:43913146C>T	uc002zbg.2	-	2	203	c.98G>A	c.(97-99)CGT>CAT	p.R33H	SLC37A1_uc002zbh.1_5'Flank	NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	33	MORN 1.				meiosis	cytosol|nucleus				ovary(1)	1						TGCCCTCCCACGTCCGTGCCT	0.448		NaN											0	0	0	1	0	137	58									
PCNT	5116	broad.mit.edu	37	21	47821561	47821562	+	Missense_Mutation	DNP	TC	TC	GA	rs147564798		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:47821561_47821562TC>GA	uc002zji.3	+	26	4995_4996	c.4888_4889TC>GA	c.(4888-4890)TCG>GAG	p.S1630E	PCNT_uc002zjj.2_Missense_Mutation_p.S1512E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1630	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CGAGCCTCCTTCGGGCAGCCCT	0.554		NaN											0	0	0	1	0	55	50									
SERPIND1	3053	broad.mit.edu	37	22	21134339	21134339	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:21134339G>A	uc002ztb.1	+	2	806	c.739G>A	c.(739-741)GAG>AAG	p.E247K	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.E275K	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	247					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TTACTTTGCTGAGGCCCAGAT	0.433		NaN											0	0	0	1	0	66	197									
SERPIND1	3053	broad.mit.edu	37	22	21134464	21134464	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:21134464G>A	uc002ztb.1	+	2	931	c.864G>A	c.(862-864)ATG>ATA	p.M288I	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.M316I	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	288					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CCCAGATGATGATTCTCAACT	0.423		NaN											0	0	0	1	0	70	217									
MN1	4330	broad.mit.edu	37	22	28193195	28193195	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:28193195A>C	uc003adj.2	-	1	4292	c.3337T>G	c.(3337-3339)TCG>GCG	p.S1113A		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1113							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						TCAGGGGTCGAGGTAGAGTTA	0.756		NaN	T	ETV6	AML|meningioma								0	0	0	1	0	6	16									
KDELR3	11015	broad.mit.edu	37	22	38875600	38875600	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:38875600G>A	uc003avv.2	+	3	351	c.195G>A	c.(193-195)GTG>GTA	p.V65V	KDELR3_uc003avu.2_Silent_p.V65V	NM_006855	NP_006846	O43731	ERD23_HUMAN	KDEL receptor 3 isoform a	65	Helical; (Potential).				protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			ovary(2)	2	Melanoma(58;0.0286)					CCTTTTAGGTGGTTTTTCTCC	0.438		NaN											0	0	0	1	0	59	47									
SREBF2	6721	broad.mit.edu	37	22	42271711	42271711	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:42271711C>G	uc003bbi.2	+	7	1538	c.1369C>G	c.(1369-1371)CTA>GTA	p.L457V	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	457	Interaction with LMNA (By similarity).|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						AGGAAGCCCTCTATTGGATGA	0.502		NaN											0	0	0	1	0	36	34									
SEPT3	55964	broad.mit.edu	37	22	42392933	42392933	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:42392933C>T	uc003bbr.3	+	11	1177	c.1039C>T	c.(1039-1041)CCA>TCA	p.P347S	WBP2NL_uc011ape.1_Intron|SEPT3_uc003bbs.3_3'UTR|SEPT3_uc010gyr.2_Missense_Mutation_p.P283S|SEPT3_uc011apj.1_3'UTR|SEPT3_uc010gys.2_Missense_Mutation_p.P127S|WBP2NL_uc003bbt.2_5'Flank|WBP2NL_uc011apk.1_5'Flank|WBP2NL_uc003bbu.2_5'Flank	NM_145733	NP_663786	Q9UH03	SEPT3_HUMAN	septin 3 isoform A	347					cell cycle|cytokinesis	cell junction|septin complex	GTP binding				0						CACTGTCCTTCCACCTGTGCC	0.577		NaN											0	0	0	1	0	46	30									
KCNH8	131096	broad.mit.edu	37	3	19575010	19575010	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:19575010G>T	uc003cbk.1	+	16	2938	c.2743G>T	c.(2743-2745)GTG>TTG	p.V915L	KCNH8_uc010hex.1_Missense_Mutation_p.V376L	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	915	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CAGCACCTCTGTGTGTCCCTC	0.522		NaN											1	0	2.47907e-22	1	2.61679e-22	57	22									
NEK10	152110	broad.mit.edu	37	3	27346359	27346359	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:27346359C>T	uc003cdt.1	-	13	1181	c.907G>A	c.(907-909)GAC>AAC	p.D303N		NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	303							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTCAAGTGGTCAGAGTGGAGC	0.542		NaN											0	0	0	1	0	19	18									
GLB1	2720	broad.mit.edu	37	3	33110348	33110348	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:33110348C>T	uc003cfi.1	-	3	477	c.360G>A	c.(358-360)CTG>CTA	p.L120L	GLB1_uc003cfh.1_Silent_p.L90L|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Silent_p.L168L	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	120					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				GCCCGGGCCTCAGGATAACCA	0.562		NaN											0	0	0	1	0	45	27									
XIRP1	165904	broad.mit.edu	37	3	39228107	39228107	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:39228107G>A	uc003cjk.1	-	2	3051	c.2830C>T	c.(2830-2832)CTG>TTG	p.L944L	XIRP1_uc003cji.2_Silent_p.L944L|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	944							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TCCCACCGCAGACTGTGCAGG	0.637		NaN											0	0	0	1	0	39	14									
GPR62	118442	broad.mit.edu	37	3	51990695	51990695	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:51990695G>A	uc003dca.3	+	1	1366	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K		NM_080865	NP_543141	Q9BZJ7	GPR62_HUMAN	G protein-coupled receptor 62	343	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGGCCCTTCTGAGGCTCCAGA	0.672		NaN											0	0	0	1	0	22	10									
ALAS1	211	broad.mit.edu	37	3	52246323	52246323	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:52246323G>A	uc003dcy.1	+	11	1986	c.1649G>A	c.(1648-1650)AGA>AAA	p.R550K	ALAS1_uc003dcz.1_Missense_Mutation_p.R550K|ALAS1_uc011bec.1_Missense_Mutation_p.R567K	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	550					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CTAATGAGCAGACATAACATC	0.498		NaN											0	0	0	1	0	197	72									
ROBO2	6092	broad.mit.edu	37	3	77657032	77657032	+	Silent	SNP	C	C	T	rs143136849		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:77657032C>T	uc003dpy.3	+	21	3863	c.3220C>T	c.(3220-3222)CTA>TTA	p.L1074L	ROBO2_uc003dpz.2_Silent_p.L1078L|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.L1078L|ROBO2_uc003dqa.2_Silent_p.L201L	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1074	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.L1074L(1)|p.L1090L(1)		lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAATGTCCCTCTACCTCCCCC	0.423		NaN											0	0	0	1	0	10	34									
GABRR3	200959	broad.mit.edu	37	3	97726706	97726706	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:97726706C>T	uc011bgr.1	-	6	656	c.656G>A	c.(655-657)GGA>GAA	p.G219E		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	219	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0						GGACTTGTTTCCGTGTTTCCA	0.343		NaN											0	0	0	1	0	6	13									
BBX	56987	broad.mit.edu	37	3	107474514	107474514	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:107474514C>T	uc010hpr.2	+	10	1222	c.895C>T	c.(895-897)CAA>TAA	p.Q299*	BBX_uc003dwk.3_Nonsense_Mutation_p.Q299*|BBX_uc003dwl.3_Nonsense_Mutation_p.Q299*|BBX_uc010hps.1_Nonsense_Mutation_p.Q320*|BBX_uc003dwm.3_Nonsense_Mutation_p.Q299*	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGCACTCTTTCAACTGGCAGA	0.368		NaN											0	0	0	1	0	25	59									
GPR156	165829	broad.mit.edu	37	3	119905579	119905579	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:119905579C>T	uc011bjf.1	-	5	526	c.526G>A	c.(526-528)GAT>AAT	p.D176N	GPR156_uc011bjg.1_Missense_Mutation_p.D176N	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	176	Helical; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		AGGATCACATCAGCCATCAAC	0.502		NaN											0	0	0	1	0	32	66									
STXBP5L	9515	broad.mit.edu	37	3	121126442	121126442	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:121126442G>A	uc003eec.3	+	24	3152	c.3012G>A	c.(3010-3012)ATG>ATA	p.M1004I	STXBP5L_uc011bji.1_Missense_Mutation_p.M980I	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	1004	WD 13.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GACATATCATGATAATGAGGT	0.373		NaN											0	0	0	1	0	32	35									
POLQ	10721	broad.mit.edu	37	3	121251880	121251880	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:121251880G>T	uc003eee.3	-	6	1046	c.917C>A	c.(916-918)TCA>TAA	p.S306*		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	306					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAGTTTCATTGAAGAGTCATA	0.383		NaN						DNA_polymerases_(catalytic_subunits)					1	0	5.50884e-06	1	5.59432e-06	13	30									
OSBPL11	114885	broad.mit.edu	37	3	125313607	125313607	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:125313607G>A	uc003eic.2	-	1	775	c.38C>T	c.(37-39)TCG>TTG	p.S13L		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	13					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						TTCGCTCTCCGAGACTTTCAT	0.408		NaN											0	0	0	1	0	15	23									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	1	0	12	8									
ATP2C1	27032	broad.mit.edu	37	3	130694262	130694262	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:130694262G>A	uc003enl.2	+	18	1722	c.1500G>A	c.(1498-1500)TTG>TTA	p.L500L	ATP2C1_uc011blg.1_Silent_p.L534L|ATP2C1_uc011blh.1_Silent_p.L495L|ATP2C1_uc011bli.1_Silent_p.L534L|ATP2C1_uc003enk.2_Silent_p.L484L|ATP2C1_uc003enm.2_Silent_p.L500L|ATP2C1_uc003enn.2_Silent_p.L484L|ATP2C1_uc003eno.2_Silent_p.L500L|ATP2C1_uc003enp.2_Silent_p.L500L|ATP2C1_uc003enq.2_Silent_p.L500L|ATP2C1_uc003enr.2_Silent_p.L500L|ATP2C1_uc003ens.2_Silent_p.L500L|ATP2C1_uc003ent.2_Silent_p.L500L|ATP2C1_uc003enu.2_Silent_p.L178L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	500	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	GGCAGACCTTGACACTTACTC	0.463		NaN							Hailey-Hailey_disease				0	0	0	1	0	25	33									
STAG1	10274	broad.mit.edu	37	3	136076567	136076567	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:136076567C>G	uc003era.1	-	28	3352	c.3060G>C	c.(3058-3060)AAG>AAC	p.K1020N	STAG1_uc003erb.1_Missense_Mutation_p.K1020N	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1020					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						CTTACACTGTCTTTTTGTCCT	0.294		NaN											0	0	0	1	0	18	34									
MRPS22	56945	broad.mit.edu	37	3	139071544	139071544	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:139071544G>A	uc003etb.2	+	6	796	c.788G>A	c.(787-789)CGT>CAT	p.R263H	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.R262H|MRPS22_uc003ete.2_Missense_Mutation_p.R222H	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	263						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GACCTTTTACGTTCAACAAGA	0.323		NaN											0	0	0	1	0	21	41									
MFSD1	64747	broad.mit.edu	37	3	158519993	158519993	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:158519993G>A	uc003fcl.1	+	1	82	c.52G>A	c.(52-54)GAG>AAG	p.E18K	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_5'UTR|MFSD1_uc011bow.1_Missense_Mutation_p.E18K|MFSD1_uc011box.1_5'UTR	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	18					transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CGGCCCTGACGAGGCCGACAG	0.682		NaN											0	0	0	1	0	4	12									
KPNA4	3840	broad.mit.edu	37	3	160219955	160219955	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:160219955A>C	uc003fdn.2	-	17	1809	c.1503T>G	c.(1501-1503)ATT>ATG	p.I501M		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	501					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TTCCGCCTTGAATTGCCTCTG	0.348		NaN											0	0	0	1	0	34	45									
MYNN	55892	broad.mit.edu	37	3	169496653	169496653	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:169496653G>A	uc003fft.2	+	3	793	c.364G>A	c.(364-366)GCT>ACT	p.A122T	MYNN_uc011bpm.1_Missense_Mutation_p.A8T|MYNN_uc003ffu.2_Missense_Mutation_p.A122T|MYNN_uc003ffv.2_Intron|MYNN_uc010hwo.2_Missense_Mutation_p.A122T|MYNN_uc003ffw.1_5'Flank	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	122						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TGCTTTTATTGCTAATCCTTC	0.343		NaN											0	0	0	1	0	24	56									
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	20	15									
MCCC1	56922	broad.mit.edu	37	3	182804570	182804570	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:182804570C>T	uc003fle.2	-	4	417	c.280G>A	c.(280-282)GAA>AAA	p.E94K	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_Intron|MCCC1_uc003flf.2_Missense_Mutation_p.M17I|MCCC1_uc003flg.2_5'UTR|MCCC1_uc011bqp.1_Missense_Mutation_p.E47K|MCCC1_uc011bqq.1_5'UTR	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	94	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GAATATGCTTCATCTGCCTGT	0.438		NaN											0	0	0	1	0	6	5									
C3orf59	151963	broad.mit.edu	37	3	192516517	192516517	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:192516517G>A	uc011bsp.1	-	2	1455	c.1134C>T	c.(1132-1134)TTC>TTT	p.F378F		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	378											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		ACTGAGGGATGAAATAATTGG	0.532		NaN											0	0	0	1	0	19	46									
RNF168	165918	broad.mit.edu	37	3	196198864	196198864	+	Silent	SNP	T	T	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:196198864T>A	uc003fwq.2	-	6	2080	c.1542A>T	c.(1540-1542)TCA>TCT	p.S514S	RNF168_uc010iah.2_Silent_p.S347S|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	514					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTTTGTCCCTTGAGCCTCTCT	0.423		NaN											0	0	0	1	0	87	191									
PIGZ	80235	broad.mit.edu	37	3	196675332	196675332	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:196675332G>A	uc003fxh.2	-	3	583	c.436C>T	c.(436-438)CAC>TAC	p.H146Y		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	146	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GGGGCCAGGTGGTACACGGCC	0.667		NaN											0	0	0	1	0	13	24									
LRCH3	84859	broad.mit.edu	37	3	197597072	197597072	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:197597072G>A	uc011bul.1	+	18	1920	c.1915G>A	c.(1915-1917)GAT>AAT	p.D639N	LRCH3_uc003fyj.1_Missense_Mutation_p.D639N|LRCH3_uc011bum.1_Missense_Mutation_p.D587N|LRCH3_uc011bun.1_Missense_Mutation_p.D485N|LRCH3_uc003fyk.2_Missense_Mutation_p.D234N	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	639						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		ACCTACCACTGATTCTACAGA	0.403		NaN											0	0	0	1	0	47	84									
ZNF718	255403	broad.mit.edu	37	4	155410	155410	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:155410C>T	uc003fzt.3	+	8	1068	c.935C>T	c.(934-936)TCA>TTA	p.S312L	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_Missense_Mutation_p.H92Y	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	312	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		AAACCCTTCTCATGCGAAGAA	0.388		NaN											0	0	0	1	0	10	17									
WHSC1	7468	broad.mit.edu	37	4	1932436	1932436	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:1932436G>A	uc003gdz.3	+	6	1670	c.1494G>A	c.(1492-1494)CAG>CAA	p.Q498Q	WHSC1_uc003geb.3_Silent_p.Q498Q|WHSC1_uc003gec.3_Silent_p.Q498Q|WHSC1_uc003ged.3_Silent_p.Q498Q|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdy.1_Silent_p.Q498Q|WHSC1_uc010icd.1_Silent_p.Q498Q|WHSC1_uc003gea.1_Silent_p.Q498Q|WHSC1_uc010ice.1_Silent_p.Q498Q|WHSC1_uc003geh.1_Silent_p.Q498Q	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	498	HMG box.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GTGAGAAGCAGAGAGCACGCT	0.537		NaN	T	IGH@	MM								0	0	0	1	0	17	28									
POLN	353497	broad.mit.edu	37	4	2209868	2209868	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:2209868G>A	uc003ger.2	-	3	560	c.560C>T	c.(559-561)TCT>TTT	p.S187F	POLN_uc010ich.1_5'UTR|POLN_uc011bvi.1_Missense_Mutation_p.S187F	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	187					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TGAGTTCCCAGAATTTAGGTA	0.368		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	33	54									
ADD1	118	broad.mit.edu	37	4	2900171	2900171	+	Silent	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:2900171C>G	uc003gfr.2	+	8	1085	c.897C>G	c.(895-897)CTC>CTG	p.L299L	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Silent_p.L299L|ADD1_uc003gfo.2_Silent_p.L299L|ADD1_uc003gfp.2_Silent_p.L299L|ADD1_uc003gfq.2_Silent_p.L299L|ADD1_uc003gfs.2_Silent_p.L299L|ADD1_uc003gft.3_Silent_p.L299L|ADD1_uc003gfu.2_Silent_p.L84L	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	299					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTCTTATTCTCCGGAACCATG	0.493		NaN											0	0	0	1	0	57	94									
CNO	55330	broad.mit.edu	37	4	6718478	6718478	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:6718478C>G	uc003gjp.1	+	1	637	c.542C>G	c.(541-543)TCG>TGG	p.S181W		NM_018366	NP_060836	Q9NUP1	CNO_HUMAN	cappuccino	181					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol					0				Colorectal(103;0.0523)		AACGTGCCCTCGCTCTTTAGC	0.622		NaN											0	0	0	1	0	6	8									
NKX3-2	579	broad.mit.edu	37	4	13543785	13543785	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:13543785C>T	uc003gmx.2	-	2	910	c.834G>A	c.(832-834)AAG>AAA	p.K278K		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	278					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGGCCACCTTCTTGGCGGCGG	0.642		NaN											0	0	0	1	0	4	11									
PI4K2B	55300	broad.mit.edu	37	4	25253958	25253958	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:25253958C>A	uc003grk.2	+	2	417	c.284C>A	c.(283-285)TCA>TAA	p.S95*	PI4K2B_uc011bxs.1_5'UTR	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	95						cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				ATTGGTACTTCAGAGATGAAT	0.383		NaN											1	0	4.35082e-09	1	4.48012e-09	19	37									
TXK	7294	broad.mit.edu	37	4	48096182	48096182	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:48096182C>T	uc003gxx.3	-	8	707	c.621G>A	c.(619-621)AAG>AAA	p.K207K	TXK_uc003gxy.1_Silent_p.K207K	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	207	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CTGAGTCATTCTTTTTTATCT	0.403		NaN											0	0	0	1	0	22	48									
FRYL	285527	broad.mit.edu	37	4	48517101	48517101	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:48517101C>T	uc003gyh.1	-	56	8486	c.7881G>A	c.(7879-7881)CTG>CTA	p.L2627L	FRYL_uc003gyf.1_Silent_p.L23L|FRYL_uc003gyg.1_Silent_p.L1323L|FRYL_uc003gyi.1_Silent_p.L1515L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2627					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTAGCTCTTTCAGAGCTAAGG	0.428		NaN											0	0	0	1	0	38	69									
CWH43	80157	broad.mit.edu	37	4	49052780	49052780	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:49052780C>T	uc003gyv.2	+	15	2117	c.1935C>T	c.(1933-1935)ATC>ATT	p.I645I	CWH43_uc011bzl.1_Silent_p.I618I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	645					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						AATTTAGGATCCCTGATGACC	0.393		NaN											0	0	0	1	0	22	41									
SCFD2	152579	broad.mit.edu	37	4	53786903	53786903	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:53786903G>T	uc003gzu.2	-	6	1830	c.1696C>A	c.(1696-1698)CAT>AAT	p.H566N	SCFD2_uc010igm.2_Missense_Mutation_p.H566N	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	566					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGGTGGGTATGATTTCCAGGA	0.393		NaN											1	0	1.1804e-14	1	1.23272e-14	25	33									
LNX1	84708	broad.mit.edu	37	4	54374161	54374161	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:54374161C>T	uc003hag.3	-	3	870	c.614G>A	c.(613-615)CGA>CAA	p.R205Q	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Missense_Mutation_p.R109Q|LNX1_uc003hah.3_Intron	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	205						cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ACCCCTAGTTCGGTTGCTCCG	0.552		NaN											0	0	0	1	0	6	21									
KIAA1211	57482	broad.mit.edu	37	4	57173841	57173841	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:57173841C>T	uc003hbk.2	+	5	652	c.261C>T	c.(259-261)ATC>ATT	p.I87I	KIAA1211_uc010iha.2_Silent_p.I80I|KIAA1211_uc011bzz.1_5'Flank|KIAA1211_uc003hbl.2_5'Flank|KIAA1211_uc003hbm.1_5'Flank	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	87										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AGCAGGACATCGTCCTCTCAG	0.517		NaN											0	0	0	1	0	16	28									
TECRL	253017	broad.mit.edu	37	4	65194231	65194231	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:65194231A>G	uc003hcv.2	-	3	439	c.330T>C	c.(328-330)TGT>TGC	p.C110C	TECRL_uc003hcw.2_Silent_p.C110C	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	110					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						GCTTCTTACCACATTCTAGCT	0.299		NaN											0	0	0	1	0	19	40									
ALB	213	broad.mit.edu	37	4	74277802	74277802	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:74277802A>T	uc003hgs.3	+	7	876	c.803A>T	c.(802-804)GAA>GTA	p.E268V	ALB_uc003hgw.3_Missense_Mutation_p.E76V|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Missense_Mutation_p.E268V|ALB_uc010iii.2_Missense_Mutation_p.E153V|ALB_uc003hgu.3_Missense_Mutation_p.E118V|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Missense_Mutation_p.E158V|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	268	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GTCCACACGGAATGCTGCCAT	0.458		NaN											0	0	0	1	0	32	62									
RASSF6	166824	broad.mit.edu	37	4	74453627	74453627	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:74453627G>A	uc003hhd.1	-	5	531	c.408C>T	c.(406-408)GAC>GAT	p.D136D	RASSF6_uc003hhc.1_Silent_p.D104D|RASSF6_uc010iik.1_Silent_p.D104D|RASSF6_uc010iil.1_Silent_p.D92D	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	136					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GATAGAGATCGTCAAATTCCC	0.383		NaN											0	0	0	1	0	19	42									
ANKRD56	345079	broad.mit.edu	37	4	77818388	77818388	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:77818388C>T	uc003hki.2	-	1	615	c.615G>A	c.(613-615)CTG>CTA	p.L205L		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	205	Ala-rich.										0						GCAGTACAGCCAGGTTGTTCT	0.731		NaN											0	0	0	1	0	4	4									
FRAS1	80144	broad.mit.edu	37	4	79434557	79434557	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:79434557C>T	uc003hlb.2	+	65	10465	c.10025C>T	c.(10024-10026)TCG>TTG	p.S3342L		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3337	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATCCACATTTCGGTGCAGATC	0.433		NaN											0	0	0	1	0	46	61									
FGF5	2250	broad.mit.edu	37	4	81207685	81207685	+	Silent	SNP	G	G	A	rs3733335		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:81207685G>A	uc003hmd.2	+	3	903	c.666G>A	c.(664-666)TCG>TCA	p.S222S	FGF5_uc003hme.2_3'UTR	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	222					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						TCAAGCAGTCGGAGCAGCCAG	0.478		NaN											0	0	0	1	0	45	52									
HELQ	113510	broad.mit.edu	37	4	84350762	84350762	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:84350762G>A	uc003hom.2	-	12	2612	c.2433C>T	c.(2431-2433)CTC>CTT	p.L811L	HELQ_uc010ikb.2_Silent_p.L744L|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	811							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						CTTTTTGTAGGAGTCCTTTTT	0.328		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	1	0	20	32									
C4orf33	132321	broad.mit.edu	37	4	130023826	130023826	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:130023826A>G	uc003igu.3	+	2	425	c.61A>G	c.(61-63)ATC>GTC	p.I21V	C4orf33_uc010ioc.1_Missense_Mutation_p.I21V|C4orf33_uc010iod.2_Missense_Mutation_p.I21V	NM_173487	NP_775758	Q8N1A6	CD033_HUMAN	hypothetical protein LOC132321	21										upper_aerodigestive_tract(1)	1						GCCCGTATTTATCAGGCTGAA	0.408		NaN											0	0	0	1	0	33	80									
ACCN5	51802	broad.mit.edu	37	4	156784856	156784856	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:156784856G>C	uc003ipe.1	-	2	138	c.91C>G	c.(91-93)CCC>GCC	p.P31A		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	31	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		CGCTCAGTGGGAGATGGCAGT	0.388		NaN											0	0	0	1	0	52	47									
ANP32C	23520	broad.mit.edu	37	4	165118255	165118255	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:165118255G>A	uc011cjk.1	-	1	609	c.609C>T	c.(607-609)GAC>GAT	p.D203D	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	203	Asp/Glu-rich (highly acidic).										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		catcctcctcgtcccctccac	0.085		NaN											0	0	0	1	0	4	11									
ODZ3	55714	broad.mit.edu	37	4	183267920	183267920	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:183267920G>A	uc003ivd.1	+	2	386	c.349G>A	c.(349-351)GAT>AAT	p.D117N	ODZ3_uc010irv.1_Missense_Mutation_p.D117N	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	117	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGCAGGGTCAGATGCTGATAC	0.532		NaN											0	0	0	1	0	4	6									
ZNF622	90441	broad.mit.edu	37	5	16458679	16458679	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:16458679G>A	uc003jfq.2	-	4	1229	c.1109C>T	c.(1108-1110)TCA>TTA	p.S370L		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	370						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						GTTCTTTTCTGAGGGCAACTC	0.393		NaN											0	0	0	1	0	14	48									
LIFR	3977	broad.mit.edu	37	5	38481864	38481864	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:38481864C>T	uc010ive.1	-	20	3459	c.3127G>A	c.(3127-3129)GAC>AAC	p.D1043N	LIFR_uc003jli.2_Missense_Mutation_p.D1043N	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	1043	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					CTAGGAGAGTCTGGAGACACT	0.403		NaN	T	PLAG1	salivary adenoma								0	0	0	1	0	49	89									
TTC33	23548	broad.mit.edu	37	5	40716332	40716332	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:40716332G>A	uc003jma.2	-	5	852	c.704C>T	c.(703-705)TCT>TTT	p.S235F	TTC33_uc011cpm.1_Missense_Mutation_p.S127F|TTC33_uc010ivg.2_3'UTR	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	235							binding			ovary(1)	1						CCCAGAAGCAGACACAATAAC	0.428		NaN											0	0	0	1	0	24	42									
PELO	53918	broad.mit.edu	37	5	52096666	52096666	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:52096666C>T	uc003jos.2	+	2	1423	c.438C>T	c.(436-438)CTC>CTT	p.L146L	ITGA1_uc003jov.2_Intron|ITGA1_uc003jou.2_Intron|PELO_uc003jot.1_Intron	NM_015946	NP_057030	Q9BRX2	PELO_HUMAN	pelota homolog	146					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding				0		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				AGGAAGGCCTCGCCCATATCT	0.582		NaN											0	0	0	1	0	21	24									
SLC38A9	153129	broad.mit.edu	37	5	54929659	54929659	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:54929659C>T	uc003jqf.2	-	14	1554	c.1353G>A	c.(1351-1353)ATG>ATA	p.M451I	SLC38A9_uc003jqd.2_Missense_Mutation_p.M388I|SLC38A9_uc010ivx.2_Missense_Mutation_p.M388I|SLC38A9_uc003jqe.2_Intron|SLC38A9_uc010ivy.2_Missense_Mutation_p.M322I	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	451	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				ATACAGTCATCATCTGGAACA	0.448		NaN											0	0	0	1	0	15	25									
CMYA5	202333	broad.mit.edu	37	5	79025761	79025761	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:79025761G>A	uc003kgc.2	+	2	1245	c.1173G>A	c.(1171-1173)CTG>CTA	p.L391L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	391						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTATGTTCCTGAGAACAACAA	0.468		NaN											0	0	0	1	0	16	9									
SRP19	6728	broad.mit.edu	37	5	112200214	112200214	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:112200214G>A	uc003kqc.2	+	3	259	c.178G>A	c.(178-180)GTA>ATA	p.V60I	SRP19_uc003kqb.1_Missense_Mutation_p.V60I|SRP19_uc011cvu.1_5'UTR|SRP19_uc011cvv.1_Silent_p.T9T	NM_003135	NP_003126	P09132	SRP19_HUMAN	signal recognition particle 19kDa	60					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		TGGACTTAACGTATTTCTTGA	0.323		NaN											0	0	0	1	0	20	21									
DTWD2	285605	broad.mit.edu	37	5	118274974	118274974	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:118274974C>T	uc003ksa.2	-	3	355	c.321G>A	c.(319-321)GTG>GTA	p.V107V		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	107											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		CTGTACGCAACACTTTGTTTT	0.333		NaN											0	0	0	1	0	11	4									
LMNB1	4001	broad.mit.edu	37	5	126113516	126113516	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:126113516G>A	uc003kud.1	+	1	684	c.316G>A	c.(316-318)GAG>AAG	p.E106K	LMNB1_uc003kuc.2_Missense_Mutation_p.E106K|LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Intron	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	106	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		GCTGCAGATCGAGCTGGGCAA	0.711		NaN											0	0	0	1	0	2	0									
FBN2	2201	broad.mit.edu	37	5	127685049	127685049	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:127685049A>G	uc003kuu.2	-	23	3418	c.2979T>C	c.(2977-2979)CGT>CGC	p.R993R	FBN2_uc003kuv.2_Silent_p.R960R	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	993	EGF-like 14; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCAAACATACACGGCCAGTCC	0.453		NaN											0	0	0	1	0	8	6									
SPINK5	11005	broad.mit.edu	37	5	147449958	147449958	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:147449958C>G	uc003lox.2	+	3	227	c.154C>G	c.(154-156)CAA>GAA	p.Q52E	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.Q24E|SPINK5_uc010jgr.2_Missense_Mutation_p.Q33E|SPINK5_uc003low.2_Missense_Mutation_p.Q52E|SPINK5_uc003loy.2_Missense_Mutation_p.Q52E	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	52	Kazal-like 1; atypical.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAATTTTTTCAAAGTCTTGA	0.328		NaN											0	0	0	1	0	28	22									
SPINK5	11005	broad.mit.edu	37	5	147499895	147499895	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:147499895G>A	uc003lox.2	+	26	2552	c.2479G>A	c.(2479-2481)GAA>AAA	p.E827K	SPINK5_uc010jgr.2_Missense_Mutation_p.E808K|SPINK5_uc003low.2_Missense_Mutation_p.E827K|SPINK5_uc003loy.2_Missense_Mutation_p.E827K	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	827	Kazal-like 12.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAGAGGATGAAGACAGGAG	0.393		NaN											0	0	0	1	0	7	7									
CSNK1A1	1452	broad.mit.edu	37	5	148930407	148930407	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:148930407C>T	uc003lqx.1	-	1	601	c.121G>A	c.(121-123)GAG>AAG	p.E41K	CSNK1A1_uc011dcc.1_5'Flank|CSNK1A1_uc003lqv.1_5'Flank|CSNK1A1_uc003lqw.1_Missense_Mutation_p.E41K|CSNK1A1_uc003lqy.1_Missense_Mutation_p.E41K|CSNK1A1_uc010jha.1_Missense_Mutation_p.E41K	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	41	Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		ATGATTACCTCGCCGTTGGTG	0.547		NaN											0	0	0	1	0	25	17									
SNCB	6620	broad.mit.edu	37	5	176053748	176053748	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:176053748C>T	uc003mep.2	-	4	579	c.136G>A	c.(136-138)GAA>AAA	p.E46K	SNCB_uc003meq.2_Missense_Mutation_p.E46K|SNCB_uc010jke.1_Missense_Mutation_p.E46K	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	46	3; approximate.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCACACCTTCTCGGGTCTTG	0.577		NaN											0	0	0	1	0	31	22									
SNCB	6620	broad.mit.edu	37	5	176053750	176053750	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:176053750C>T	uc003mep.2	-	4	577	c.134G>A	c.(133-135)CGA>CAA	p.R45Q	SNCB_uc003meq.2_Missense_Mutation_p.R45Q|SNCB_uc010jke.1_Missense_Mutation_p.R45Q	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	45	3; approximate.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACACCTTCTCGGGTCTTGCT	0.572		NaN											0	0	0	1	0	31	22									
RREB1	6239	broad.mit.edu	37	6	7182305	7182305	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:7182305G>A	uc003mxc.2	+	4	551	c.161G>A	c.(160-162)AGA>AAA	p.R54K	RREB1_uc010jnw.2_Missense_Mutation_p.R54K|RREB1_uc003mxb.2_Missense_Mutation_p.R54K|RREB1_uc010jnx.2_Missense_Mutation_p.R54K|RREB1_uc003mxd.2_Missense_Mutation_p.R54K	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	54					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CGGATTGGCAGAAGGAACCAG	0.527		NaN											0	0	0	1	0	23	15									
DSP	1832	broad.mit.edu	37	6	7542296	7542296	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:7542296G>A	uc003mxp.1	+	1	427	c.148G>A	c.(148-150)GAC>AAC	p.D50N	DSP_uc003mxq.1_Missense_Mutation_p.D50N	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	50	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CGTGATCACCGACCAGAACTC	0.701		NaN											0	0	0	1	0	2	1									
BMP6	654	broad.mit.edu	37	6	7880494	7880494	+	Missense_Mutation	SNP	C	C	T	rs139361183		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:7880494C>T	uc003mxu.3	+	7	1638	c.1460C>T	c.(1459-1461)TCG>TTG	p.S487L		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	487					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					AATGCCATCTCGGTTCTTTAC	0.448		NaN											0	0	0	1	0	56	53									
HIST1H1B	3009	broad.mit.edu	37	6	27835260	27835260	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:27835260C>T	uc003njx.2	-	1	100	c.48G>A	c.(46-48)GAG>GAA	p.E16E		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	16					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CCGGGGATTTCTCCACCGGCG	0.582		NaN											0	0	0	1	0	26	11									
GNL1	2794	broad.mit.edu	37	6	30523426	30523426	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:30523426C>T	uc003nqh.2	-	2	1173	c.145G>A	c.(145-147)GAC>AAC	p.D49N	GNL1_uc011dmi.1_5'UTR|GNL1_uc011dmj.1_Missense_Mutation_p.D47N|GNL1_uc011dmk.1_Intron|PRR3_uc003nqi.1_5'Flank|PRR3_uc003nqj.1_5'Flank	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	49					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						TCCGAGGTGTCGGTCTGTTCC	0.662		NaN											0	0	0	1	0	19	17									
HLA-C	3107	broad.mit.edu	37	6	31239458	31239458	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31239458C>T	uc003nsy.2	-	2	268	c.261G>A	c.(259-261)GAG>GAA	p.E87E	HLA-C_uc011dnj.1_Silent_p.E59E|HLA-C_uc003nsx.2_5'UTR|HLA-C_uc003nsz.2_Silent_p.E87E|HLA-C_uc010jsl.2_Silent_p.E87E|HLA-C_uc003nta.2_Silent_p.E87E|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_5'UTR|HLA-B_uc003ntf.2_Intron	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	87	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						ACTTCTGTGTCTCCCGGTCCC	0.687		NaN											0	0	0	1	0	16	14									
DDAH2	23564	broad.mit.edu	37	6	31695035	31695035	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31695035G>A	uc003nwp.2	-	6	1468	c.837C>T	c.(835-837)CTC>CTT	p.L279L	DDAH2_uc003nwq.2_Silent_p.L279L	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	279					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	GGCGTGTGCTGAGCACCAAGC	0.592		NaN											0	0	0	1	0	50	53									
SLC44A4	80736	broad.mit.edu	37	6	31842778	31842778	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31842778G>A	uc010jti.2	-	5	336	c.270C>T	c.(268-270)AAC>AAT	p.N90N	SLC44A4_uc011dol.1_Silent_p.N14N|SLC44A4_uc011dom.1_Silent_p.N90N	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	90	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	AGCTGAAGATGTTGAAGTACA	0.597		NaN											0	0	0	1	0	44	27									
EHMT2	10919	broad.mit.edu	37	6	31864542	31864542	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31864542C>T	uc003nxz.1	-	3	179	c.169G>A	c.(169-171)GAC>AAC	p.D57N	EHMT2_uc003nxy.1_5'UTR|EHMT2_uc011don.1_Missense_Mutation_p.D114N|EHMT2_uc003nya.1_Missense_Mutation_p.D57N|EHMT2_uc003nyb.1_Missense_Mutation_p.D57N|C2_uc003nyc.2_5'Flank|C2_uc011doo.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	57					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TCCAGGGAGTCGGGGGTGGCC	0.582		NaN											0	0	0	1	0	30	21									
RXRB	6257	broad.mit.edu	37	6	33162525	33162525	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:33162525G>A	uc003odb.2	-	10	1715	c.1536C>T	c.(1534-1536)CTC>CTT	p.L512L	RXRB_uc003odc.2_Silent_p.L516L|RXRB_uc003odd.2_Silent_p.L416L|RXRB_uc011dqr.1_Silent_p.L326L	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	512	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TGTCACCAATGAGCTTGAAGA	0.557		NaN											0	0	0	1	0	16	13									
C6orf89	221477	broad.mit.edu	37	6	36882094	36882094	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:36882094G>A	uc003omx.2	+	5	722	c.438G>A	c.(436-438)CAG>CAA	p.Q146Q	C6orf89_uc003omv.2_Silent_p.Q40Q|C6orf89_uc003omw.2_Silent_p.Q153Q|C6orf89_uc011dtr.1_Silent_p.Q40Q|C6orf89_uc003omy.2_5'UTR	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	146						integral to membrane				ovary(1)	1						ACTGTGAGCAGAATGAGTCAG	0.517		NaN											0	0	0	1	0	21	21									
CCND3	896	broad.mit.edu	37	6	41903779	41903779	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:41903779G>A	uc003orn.2	-	5	943	c.778C>T	c.(778-780)CAG>TAG	p.Q260*	CCND3_uc003orp.2_Nonsense_Mutation_p.Q179*|CCND3_uc011duk.1_Nonsense_Mutation_p.Q64*|CCND3_uc003orm.2_Nonsense_Mutation_p.Q210*|CCND3_uc003oro.2_Nonsense_Mutation_p.Q188*	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	260					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GAGCTGGTCTGAGAGGCTTCC	0.627		NaN	T	IGH@	MM								0	0	0	1	0	6	3									
HMGCLL1	54511	broad.mit.edu	37	6	55304265	55304265	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:55304265C>G	uc003pcn.2	-	9	1137	c.978G>C	c.(976-978)TTG>TTC	p.L326F	HMGCLL1_uc003pco.2_Missense_Mutation_p.L296F|HMGCLL1_uc010jzx.2_Missense_Mutation_p.L197F|HMGCLL1_uc011dxc.1_Missense_Mutation_p.L264F|HMGCLL1_uc011dxd.1_Missense_Mutation_p.L193F|HMGCLL1_uc011dxe.1_Missense_Mutation_p.L130F	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	326							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCATATATATCAAATCCTCAG	0.418		NaN											0	0	0	1	0	30	22									
COL9A1	1297	broad.mit.edu	37	6	70944596	70944596	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:70944596C>T	uc003pfg.3	-	34	2319	c.2160G>A	c.(2158-2160)CGG>CGA	p.R720R	COL9A1_uc003pfe.3_Silent_p.R269R|COL9A1_uc003pff.3_Silent_p.R477R	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	720	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CAGGAAGCCCCCGACTTCCCT	0.612		NaN											0	0	0	1	0	13	11									
LACE1	246269	broad.mit.edu	37	6	108676919	108676919	+	Silent	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:108676919A>G	uc003psj.2	+	4	663	c.477A>G	c.(475-477)AAA>AAG	p.K159K		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	159							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		AGAGGAAAAAACGGGTTCATT	0.303		NaN											0	0	0	1	0	34	16									
TRAF3IP2	10758	broad.mit.edu	37	6	111912967	111912967	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:111912967G>A	uc011ebc.1	-	3	938	c.323C>T	c.(322-324)TCT>TTT	p.S108F	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.S108F|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.S108F|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.S108F|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.S108F	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	117					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		AGAGCACCCAGAAGGGAAAGC	0.552		NaN											0	0	0	1	0	20	17									
LAMA4	3910	broad.mit.edu	37	6	112466047	112466047	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:112466047G>A	uc003pvu.2	-	19	2751	c.2442C>T	c.(2440-2442)AGC>AGT	p.S814S	LAMA4_uc003pvv.2_Silent_p.S807S|LAMA4_uc003pvt.2_Silent_p.S807S	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	814	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TCCTCTGGATGCTGGCAGAAA	0.488		NaN											0	0	0	1	0	30	12									
LAMA2	3908	broad.mit.edu	37	6	129826498	129826498	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:129826498C>T	uc003qbn.2	+	60	8806	c.8701C>T	c.(8701-8703)CCA>TCA	p.P2901S	LAMA2_uc003qbo.2_Missense_Mutation_p.P2897S|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2901	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAGAATTGGTCCAGTAAATAT	0.383		NaN											0	0	0	1	0	28	10									
REPS1	85021	broad.mit.edu	37	6	139265753	139265753	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:139265753G>A	uc003qii.2	-	5	1214	c.635C>T	c.(634-636)TCT>TTT	p.S212F	REPS1_uc003qig.3_Missense_Mutation_p.S212F|REPS1_uc011edr.1_Missense_Mutation_p.S212F|REPS1_uc003qij.2_Missense_Mutation_p.S212F|REPS1_uc003qik.2_Intron	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	212						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		ATCACCAGCAGAAGAACCTAT	0.428		NaN											0	0	0	1	0	22	28									
THBS2	7058	broad.mit.edu	37	6	169648584	169648584	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:169648584G>A	uc003qwt.2	-	4	785	c.537C>T	c.(535-537)TTC>TTT	p.F179F		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	179	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGTGCTCGTAGAAGGGCTCGT	0.617		NaN											0	0	0	1	0	39	36									
MAFK	7975	broad.mit.edu	37	7	1579901	1579901	+	Missense_Mutation	SNP	G	G	A	rs143840628		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:1579901G>A	uc003skr.2	+	3	572	c.361G>A	c.(361-363)GTG>ATG	p.V121M	MAFK_uc003sks.1_RNA	NM_002360	NP_002351	O60675	MAFK_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	121					blood coagulation	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.75e-15)		CGCGCGCACCGTGGCCCGGGG	0.682		NaN											0	0	0	1	0	3	7									
CREB5	9586	broad.mit.edu	37	7	28858777	28858777	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:28858777C>T	uc003szq.2	+	11	1798	c.1408C>T	c.(1408-1410)CAG>TAG	p.Q470*	CREB5_uc003szo.2_Nonsense_Mutation_p.Q437*|CREB5_uc003szr.2_Nonsense_Mutation_p.Q463*|CREB5_uc003szs.2_Nonsense_Mutation_p.Q331*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	470					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AGCTTGCTCCCAGCAACAAGT	0.502		NaN											0	0	0	1	0	46	81									
AOAH	313	broad.mit.edu	37	7	36726373	36726373	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:36726373C>T	uc003tfh.3	-	2	555	c.154G>A	c.(154-156)GAA>AAA	p.E52K	AOAH_uc010kxf.2_Missense_Mutation_p.E52K|AOAH_uc011kba.1_Intron	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	52	Saposin B-type.				inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GCAAGCTGTTCTATTACAGAC	0.512		NaN											0	0	0	1	0	14	33									
NPC1L1	29881	broad.mit.edu	37	7	44556401	44556401	+	Silent	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:44556401G>C	uc003tlb.2	-	17	3557	c.3501C>G	c.(3499-3501)CTC>CTG	p.L1167L	NPC1L1_uc003tlc.2_Silent_p.L1140L|NPC1L1_uc011kbw.1_Silent_p.L1094L|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1167	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AGAGCAGGTTGAGGAGGCCGG	0.612		NaN											0	0	0	1	0	3	12									
TNS3	64759	broad.mit.edu	37	7	47344505	47344505	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:47344505G>A	uc003tnv.2	-	21	3114	c.2747C>T	c.(2746-2748)TCG>TTG	p.S916L	TNS3_uc003tnw.2_Missense_Mutation_p.S916L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	916						focal adhesion	protein binding			ovary(4)	4						GGAGGGCGTCGAGGACGCATC	0.567		NaN											0	0	0	1	0	10	13									
ZNF107	51427	broad.mit.edu	37	7	64168093	64168093	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:64168093G>C	uc003ttd.2	+	7	2197	c.1411G>C	c.(1411-1413)GAG>CAG	p.E471Q	ZNF107_uc003tte.2_Missense_Mutation_p.E471Q	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	471	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CTATAAATGTGAGGAATGTGG	0.363		NaN											0	0	0	1	0	19	35									
TYW1	55253	broad.mit.edu	37	7	66463931	66463931	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:66463931G>A	uc003tvn.2	+	3	412	c.263G>A	c.(262-264)GGA>GAA	p.G88E	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	88	FMN (By similarity).|Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				TCTCAGACTGGAACAGCGAAG	0.378		NaN											0	0	0	1	0	25	56									
TRIM50	135892	broad.mit.edu	37	7	72738632	72738632	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:72738632G>A	uc010lbd.1	-	2	279	c.154C>T	c.(154-156)CGC>TGC	p.R52C	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.R52C|TRIM50_uc003txz.1_Missense_Mutation_p.R52C	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	52	RING-type.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						ACGGGGCAGCGCAGCTCGGCA	0.677		NaN									OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	23	44									
PCLO	27445	broad.mit.edu	37	7	82583410	82583410	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:82583410C>T	uc003uhx.2	-	5	7148	c.6859G>A	c.(6859-6861)GAC>AAC	p.D2287N	PCLO_uc003uhv.2_Missense_Mutation_p.D2287N|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2218					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAAACAGTGTCAGCAACTGGC	0.393		NaN											0	0	0	1	0	43	88									
DBF4	10926	broad.mit.edu	37	7	87533643	87533643	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:87533643A>G	uc003ujf.1	+	11	1465	c.961A>G	c.(961-963)AGT>GGT	p.S321G	DBF4_uc003ujh.1_Missense_Mutation_p.S61G|DBF4_uc003ujg.1_Missense_Mutation_p.S97G|DBF4_uc011khf.1_Missense_Mutation_p.S88G	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	321	DBF4-type.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				CTTTGCACAGAGTAACCAGTA	0.284		NaN											0	0	0	1	0	26	26									
ADAM22	53616	broad.mit.edu	37	7	87797475	87797475	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:87797475A>T	uc003ujn.2	+	25	2294	c.2215A>T	c.(2215-2217)ATA>TTA	p.I739L	ADAM22_uc003ujk.1_Missense_Mutation_p.I739L|ADAM22_uc003ujl.1_Missense_Mutation_p.I739L|ADAM22_uc003ujm.2_Missense_Mutation_p.I739L|ADAM22_uc003ujo.2_Missense_Mutation_p.I739L|ADAM22_uc003ujp.1_Missense_Mutation_p.I791L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	739	Helical; (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CAATATCATAATAGGCATAAT	0.363		NaN											0	0	0	1	0	14	34									
KRIT1	889	broad.mit.edu	37	7	91863905	91863905	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:91863905C>T	uc003ulq.1	-	8	1018	c.847G>A	c.(847-849)GAA>AAA	p.E283K	KRIT1_uc010lev.1_Missense_Mutation_p.E76K|KRIT1_uc003ulr.1_Missense_Mutation_p.E283K|KRIT1_uc003uls.1_Missense_Mutation_p.E283K|KRIT1_uc003ult.1_Intron|KRIT1_uc003ulu.1_Missense_Mutation_p.E283K|KRIT1_uc003ulv.1_Missense_Mutation_p.E283K	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	283					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CACTGTCGTTCCCTAATCATT	0.368		NaN							Familial_Cerebral_Cavernous_Angioma				0	0	0	1	0	26	43									
CDK6	1021	broad.mit.edu	37	7	92462443	92462443	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:92462443C>T	uc011khw.1	-	2	607	c.195G>A	c.(193-195)CTG>CTA	p.L65L	CDK6_uc010lez.2_Silent_p.L65L	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	65	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CCAGGTGCCTCAGCACCGCCA	0.706		NaN	T	MLLT10	ALL						OREG0018165	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	5									
ZAN	7455	broad.mit.edu	37	7	100364685	100364685	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:100364685C>T	uc003uwj.2	+	25	4830	c.4665C>T	c.(4663-4665)GGC>GGT	p.G1555G	ZAN_uc003uwk.2_Silent_p.G1555G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.G132G	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1555	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCTTCGATGGCGCCTTGCACC	0.602		NaN											0	0	0	1	0	15	39									
NAMPT	10135	broad.mit.edu	37	7	105909656	105909656	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:105909656C>T	uc003vdq.2	-	5	858	c.550G>A	c.(550-552)GAT>AAT	p.D184N	NAMPT_uc003vdr.1_Missense_Mutation_p.D184N|NAMPT_uc011klu.1_Missense_Mutation_p.D97N	NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	184					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						TCCAGACCATCTAAGTTACCA	0.368		NaN											0	0	0	1	0	11	28									
DLD	1738	broad.mit.edu	37	7	107531736	107531736	+	Splice_Site	SNP	T	T	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:107531736T>A	uc003vet.2	+	1	149	c.39_splice	c.e1+2	p.K13_splice	DLD_uc010ljm.1_Splice_Site|DLD_uc011kmg.1_Splice_Site_p.K13_splice|DLD_uc011kmh.1_Splice_Site_p.K13_splice|DLD_uc011kmi.1_Splice_Site	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor						branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	TTGGCCAAGGTGAGGGCCGAG	0.622		NaN											0	0	0	1	0	12	21									
FOXP2	93986	broad.mit.edu	37	7	114299688	114299688	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:114299688G>T	uc003vhb.2	+	13	1981	c.1607G>T	c.(1606-1608)CGG>CTG	p.R536L	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.R561L|FOXP2_uc003vha.2_Missense_Mutation_p.R444L|FOXP2_uc011kmu.1_Missense_Mutation_p.R553L|FOXP2_uc011kmv.1_Missense_Mutation_p.R535L|FOXP2_uc010ljz.1_Missense_Mutation_p.R351L|FOXP2_uc003vhe.1_Missense_Mutation_p.R106L	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	536	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TGGTTTACACGGACATTTGCT	0.343		NaN											1	0	0.00621372	1	0.00624553	9	78									
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507		NaN											0	0	0	1	0	14	30									
RBM28	55131	broad.mit.edu	37	7	127961459	127961459	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:127961459G>C	uc003vmp.2	-	14	1538	c.1423C>G	c.(1423-1425)CAG>GAG	p.Q475E	RBM28_uc003vmo.2_Missense_Mutation_p.Q92E|RBM28_uc011koj.1_Missense_Mutation_p.Q334E	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	475					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TTGAGTTTCTGATGCTTCAGC	0.433		NaN											0	0	0	1	0	15	30									
TNPO3	23534	broad.mit.edu	37	7	128630024	128630024	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:128630024G>A	uc003vol.1	-	11	1863	c.1489C>T	c.(1489-1491)CAG>TAG	p.Q497*	TNPO3_uc003vom.1_Nonsense_Mutation_p.Q431*|TNPO3_uc010lly.1_Nonsense_Mutation_p.Q531*|TNPO3_uc010llz.1_Nonsense_Mutation_p.Q497*	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	497					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						CCAAGGAACTGAGGATTTCGA	0.438		NaN											0	0	0	1	0	23	50									
LUC7L2	51631	broad.mit.edu	37	7	139107066	139107066	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:139107066C>T	uc003vux.2	+	10	1533	c.1159C>T	c.(1159-1161)CGC>TGC	p.R387C	LUC7L2_uc011kqs.1_Missense_Mutation_p.R384C|LUC7L2_uc011kqt.1_Missense_Mutation_p.R453C|LUC7L2_uc003vuy.2_Missense_Mutation_p.R386C|LUC7L2_uc003vva.2_Missense_Mutation_p.R334C	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	387	Arg/Ser-rich.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)					CTCTGAAGAGCGCGAAGCAGG	0.468		NaN											0	0	0	1	0	22	73									
EZH2	2146	broad.mit.edu	37	7	148523641	148523641	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:148523641G>T	uc003wfd.1	-	8	978	c.812C>A	c.(811-813)TCT>TAT	p.S271Y	EZH2_uc011kug.1_Missense_Mutation_p.S262Y|EZH2_uc003wfb.1_Missense_Mutation_p.S271Y|EZH2_uc003wfc.1_Missense_Mutation_p.S232Y|EZH2_uc011kuh.1_Missense_Mutation_p.S262Y|EZH2_uc011kui.1_Missense_Mutation_p.S271Y|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	271	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TCTCTGAACAGATTTAGCATT	0.423		NaN	Mis		DLBCL								1	0	6.72482e-11	1	6.9612e-11	15	37									
AGAP3	116988	broad.mit.edu	37	7	150817139	150817139	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:150817139C>T	uc003wjg.1	+	8	1038	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	AGAP3_uc003wje.1_Silent_p.I117I|AGAP3_uc003wjf.1_Silent_p.I345I|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Silent_p.I525I|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	309	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						CCCCCAGCATCAGCCAGCGGG	0.652		NaN											0	0	0	1	0	18	12									
NOM1	64434	broad.mit.edu	37	7	156746908	156746908	+	Silent	SNP	C	C	T	rs114285170	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:156746908C>T	uc003wmy.2	+	3	1239	c.1224C>T	c.(1222-1224)TGC>TGT	p.C408C		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	408	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		TGGGTGCCTGCGTCACTGCCT	0.542		NaN											0	0	0	1	0	4	45									
ESYT2	57488	broad.mit.edu	37	7	158557520	158557520	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:158557520C>T	uc003wob.1	-	9	1159	c.1093G>A	c.(1093-1095)GAA>AAA	p.E365K	ESYT2_uc003woc.1_Missense_Mutation_p.E189K|ESYT2_uc003wod.1_Missense_Mutation_p.E365K|ESYT2_uc003woa.1_5'Flank	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	393	C2 1.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TCCTGAGCTTCAATAAAATGT	0.428		NaN											0	0	0	1	0	34	64									
CSMD1	64478	broad.mit.edu	37	8	4277529	4277529	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:4277529A>G	uc011kwk.1	-	3	751	c.361T>C	c.(361-363)TGG>CGG	p.W121R		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	121	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTCGTGAACCACAGAGTGAGG	0.413		NaN											0	0	0	1	0	3	5									
RP1L1	94137	broad.mit.edu	37	8	10467275	10467275	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:10467275C>T	uc003wtc.2	-	4	4562	c.4333G>A	c.(4333-4335)GAG>AAG	p.E1445K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1445					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCTGTGCCCTCTGCGGGGCAC	0.632		NaN											0	0	0	1	0	99	126									
LONRF1	91694	broad.mit.edu	37	8	12583256	12583256	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:12583256C>T	uc003wwd.1	-	11	2206	c.2143G>A	c.(2143-2145)GAG>AAG	p.E715K	LONRF1_uc011kxv.1_Missense_Mutation_p.E304K|LONRF1_uc010lsp.1_Missense_Mutation_p.E315K	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	715	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		TCCTCCCTCTCGGGCATTGAT	0.393		NaN											0	0	0	1	0	22	39									
DUSP4	1846	broad.mit.edu	37	8	29197718	29197718	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:29197718G>C	uc003xhm.2	-	2	866	c.476C>G	c.(475-477)TCT>TGT	p.S159C	DUSP4_uc003xhl.2_Missense_Mutation_p.S68C	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	159	Rhodanese.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CTTGGTTTTAGAACAGAATTC	0.572		NaN									OREG0018686	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	5									
GTF2E2	2961	broad.mit.edu	37	8	30464631	30464631	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:30464631C>T	uc003xig.2	-	6	839	c.586G>A	c.(586-588)GAT>AAT	p.D196N		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	196					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		TTCTTCTTATCGGGACGATTT	0.308		NaN											0	0	0	1	0	23	16									
PRKDC	5591	broad.mit.edu	37	8	48749802	48749802	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:48749802C>T	uc003xqi.2	-	58	7789	c.7732G>A	c.(7732-7734)GAG>AAG	p.E2578K	PRKDC_uc003xqj.2_Missense_Mutation_p.E2578K|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2578	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGAGGATGCTCGAACATGGGG	0.373		NaN						NHEJ					0	0	0	1	0	6	16									
NPBWR1	2831	broad.mit.edu	37	8	53853373	53853373	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:53853373C>T	uc011ldu.1	+	1	906	c.906C>T	c.(904-906)CTC>CTT	p.L302L		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	302	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				ACAGCTGCCTCAACCCCTTCC	0.652		NaN											0	0	0	1	0	12	35									
TGS1	96764	broad.mit.edu	37	8	56699306	56699306	+	Missense_Mutation	SNP	C	C	A	rs146870824	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:56699306C>A	uc003xsj.3	+	4	1236	c.849C>A	c.(847-849)AAC>AAA	p.N283K	TGS1_uc010lyh.2_Missense_Mutation_p.N187K	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	283					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ATGACAAGAACGATGAAAAAT	0.368		NaN											1	0	1.86633e-21	1	1.96298e-21	50	95									
IMPAD1	54928	broad.mit.edu	37	8	57905976	57905976	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:57905976C>T	uc003xte.3	-	1	452	c.169G>A	c.(169-171)GAT>AAT	p.D57N		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	57						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				GTGCCCCCATcggccgcggcc	0.577		NaN											0	0	0	1	0	6	8									
TOX	9760	broad.mit.edu	37	8	59720693	59720693	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:59720693C>T	uc003xtw.1	-	8	1749	c.1528G>A	c.(1528-1530)GAC>AAC	p.D510N		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	510						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CTGCAGTAGTCGTTATTCCAG	0.537		NaN									OREG0018787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	21	43									
RRS1	23212	broad.mit.edu	37	8	67342183	67342183	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:67342183C>T	uc003xwa.2	+	1	921	c.817C>T	c.(817-819)CGT>TGT	p.R273C	ADHFE1_uc003xwb.3_5'Flank|ADHFE1_uc003xwd.3_5'Flank|ADHFE1_uc003xwc.3_5'Flank|ADHFE1_uc003xwe.3_5'Flank|ADHFE1_uc003xwf.3_5'Flank|ADHFE1_uc011les.1_5'Flank|ADHFE1_uc011leq.1_5'Flank|ADHFE1_uc011ler.1_5'Flank	NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	273					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			GGAGCTGCTTCGTGTCATGAA	0.557		NaN											0	0	0	1	0	14	25									
RDH10	157506	broad.mit.edu	37	8	74231361	74231361	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:74231361G>C	uc003xzi.2	+	3	816	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	RDH10_uc003xzj.2_Missense_Mutation_p.E21Q|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	186					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			TACGATGCTGGAGATTAATCA	0.383		NaN											0	0	0	1	0	45	78									
LRRCC1	85444	broad.mit.edu	37	8	86048162	86048162	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:86048162G>C	uc003ycw.2	+	14	2447	c.2293G>C	c.(2293-2295)GAA>CAA	p.E765Q	LRRCC1_uc010maa.1_Missense_Mutation_p.E466Q|LRRCC1_uc003ycx.2_Missense_Mutation_p.E672Q|LRRCC1_uc003ycy.2_Missense_Mutation_p.E745Q	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	765					cell division|mitosis	centriole|nucleus					0						TTTAAGGACAGAAAGAAAAGT	0.363		NaN											0	0	0	1	0	20	34									
RAD54B	25788	broad.mit.edu	37	8	95419768	95419768	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:95419768C>T	uc003ygk.2	-	5	778	c.680G>A	c.(679-681)TGT>TAT	p.C227Y	RAD54B_uc010may.1_Missense_Mutation_p.C34Y|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GTTAGAGAAACATTTCCTGGC	0.428		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	1	0	27	53									
OSR2	116039	broad.mit.edu	37	8	99961579	99961579	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:99961579G>C	uc003yir.2	+	2	934	c.399G>C	c.(397-399)ATG>ATC	p.M133I	OSR2_uc010mbn.2_Missense_Mutation_p.M133I|OSR2_uc003yiq.2_Missense_Mutation_p.M133I|OSR2_uc011lgx.1_Missense_Mutation_p.M254I	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	133					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CGCCTAAGATGGGAGACCTGA	0.612		NaN											0	0	0	1	0	48	103									
FAM83H	286077	broad.mit.edu	37	8	144810877	144810877	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144810877C>G	uc003yzk.2	-	5	823	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	252					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGGATCTTCTCAAAGGACCAC	0.657		NaN											0	0	0	1	0	13	28									
PLEC	5339	broad.mit.edu	37	8	144995372	144995372	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144995372C>G	uc003zaf.1	-	32	9198	c.9028G>C	c.(9028-9030)GAG>CAG	p.E3010Q	PLEC_uc003zab.1_Missense_Mutation_p.E2873Q|PLEC_uc003zac.1_Missense_Mutation_p.E2877Q|PLEC_uc003zad.2_Missense_Mutation_p.E2873Q|PLEC_uc003zae.1_Missense_Mutation_p.E2841Q|PLEC_uc003zag.1_Missense_Mutation_p.E2851Q|PLEC_uc003zah.2_Missense_Mutation_p.E2859Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2900Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3010	Globular 2.|Plectin 5.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCGGGGTCCTCCACGCAGCGC	0.647		NaN											0	0	0	1	0	41	76									
PLEC	5339	broad.mit.edu	37	8	144995411	144995411	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144995411C>T	uc003zaf.1	-	32	9159	c.8989G>A	c.(8989-8991)GAG>AAG	p.E2997K	PLEC_uc003zab.1_Missense_Mutation_p.E2860K|PLEC_uc003zac.1_Missense_Mutation_p.E2864K|PLEC_uc003zad.2_Missense_Mutation_p.E2860K|PLEC_uc003zae.1_Missense_Mutation_p.E2828K|PLEC_uc003zag.1_Missense_Mutation_p.E2838K|PLEC_uc003zah.2_Missense_Mutation_p.E2846K|PLEC_uc003zaj.2_Missense_Mutation_p.E2887K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2997	Globular 2.|Plectin 5.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGAGGTTCTCGTGCGTGTTG	0.657		NaN											0	0	0	1	0	45	81									
PLEC	5339	broad.mit.edu	37	8	144995865	144995865	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144995865C>G	uc003zaf.1	-	32	8705	c.8535G>C	c.(8533-8535)GAG>GAC	p.E2845D	PLEC_uc003zab.1_Missense_Mutation_p.E2708D|PLEC_uc003zac.1_Missense_Mutation_p.E2712D|PLEC_uc003zad.2_Missense_Mutation_p.E2708D|PLEC_uc003zae.1_Missense_Mutation_p.E2676D|PLEC_uc003zag.1_Missense_Mutation_p.E2686D|PLEC_uc003zah.2_Missense_Mutation_p.E2694D|PLEC_uc003zaj.2_Missense_Mutation_p.E2735D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2845	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CACTCAGCTTCTCATTGGTGG	0.672		NaN											0	0	0	1	0	20	39									
PLEC	5339	broad.mit.edu	37	8	144996723	144996723	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144996723C>G	uc003zaf.1	-	31	7955	c.7785G>C	c.(7783-7785)GAG>GAC	p.E2595D	PLEC_uc003zab.1_Missense_Mutation_p.E2458D|PLEC_uc003zac.1_Missense_Mutation_p.E2462D|PLEC_uc003zad.2_Missense_Mutation_p.E2458D|PLEC_uc003zae.1_Missense_Mutation_p.E2426D|PLEC_uc003zag.1_Missense_Mutation_p.E2436D|PLEC_uc003zah.2_Missense_Mutation_p.E2444D|PLEC_uc003zaj.2_Missense_Mutation_p.E2485D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2595	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCTTCTCCTTCTCACGCTCCA	0.637		NaN											0	0	0	1	0	9	19									
PLEC	5339	broad.mit.edu	37	8	144997295	144997295	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144997295C>A	uc003zaf.1	-	31	7383	c.7213G>T	c.(7213-7215)GAG>TAG	p.E2405*	PLEC_uc003zab.1_Nonsense_Mutation_p.E2268*|PLEC_uc003zac.1_Nonsense_Mutation_p.E2272*|PLEC_uc003zad.2_Nonsense_Mutation_p.E2268*|PLEC_uc003zae.1_Nonsense_Mutation_p.E2236*|PLEC_uc003zag.1_Nonsense_Mutation_p.E2246*|PLEC_uc003zah.2_Nonsense_Mutation_p.E2254*|PLEC_uc003zaj.2_Nonsense_Mutation_p.E2295*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2405	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCAGCCTCCTCCTGCAGGAAG	0.642		NaN											1	0	3.07112e-06	1	3.13499e-06	9	21									
PPP1R16A	84988	broad.mit.edu	37	8	145726105	145726105	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:145726105G>T	uc003zdd.2	+	8	1781	c.868G>T	c.(868-870)GAC>TAC	p.D290Y	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.D290Y|GPT_uc011lli.1_5'Flank	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	290	ANK 5.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCACGGGGCCGACCTGAACGC	0.721		NaN											1	0	3.09899e-07	1	3.17444e-07	9	8									
SMARCA2	6595	broad.mit.edu	37	9	2115859	2115859	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:2115859A>C	uc003zhc.2	+	25	3593	c.3494A>C	c.(3493-3495)CAG>CCG	p.Q1165P	SMARCA2_uc003zhd.2_Missense_Mutation_p.Q1165P|SMARCA2_uc010mha.2_Missense_Mutation_p.Q1098P	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1165	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CGCATCGGGCAGCAGAACGAG	0.562		NaN											0	0	0	1	0	9	8									
C9orf102	375748	broad.mit.edu	37	9	98660209	98660209	+	Silent	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:98660209C>T	uc004avt.3	+	3	971	c.583C>T	c.(583-585)CTA>TTA	p.L195L	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_5'UTR|C9orf102_uc010mry.1_5'UTR|C9orf102_uc010mrz.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	195	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				AGAGTTTTTACTAAGAAGTAT	0.338		NaN											0	0	0	1	0	31	62									
KIAA1529	57653	broad.mit.edu	37	9	100092767	100092767	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:100092767C>G	uc011lut.1	+	30	3314	c.2541C>G	c.(2539-2541)TTC>TTG	p.F847L	KIAA1529_uc004axe.1_Missense_Mutation_p.F847L|KIAA1529_uc004axg.1_Missense_Mutation_p.F708L|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.F32L|KIAA1529_uc011lus.1_Missense_Mutation_p.F665L|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.F708L|KIAA1529_uc011luv.1_Missense_Mutation_p.F705L	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TGGAGTCCTTCATAACTGAAG	0.463		NaN											0	0	0	1	0	16	36									
TRIM14	9830	broad.mit.edu	37	9	100850218	100850218	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:100850218G>T	uc004ayd.2	-	6	881	c.863C>A	c.(862-864)ACG>AAG	p.T288K	TRIM14_uc004ayf.1_Missense_Mutation_p.T195K|TRIM14_uc011luz.1_Missense_Mutation_p.T66K|TRIM14_uc011lva.1_Missense_Mutation_p.T69K|TRIM14_uc004ayg.1_Missense_Mutation_p.T288K|TRIM14_uc004ayh.1_Missense_Mutation_p.T288K|TRIM14_uc004ayi.1_Intron|TRIM14_uc004ayj.1_Missense_Mutation_p.T195K	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	288	B30.2/SPRY.					cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCAGCGCACCGTCAGGCGATC	0.736		NaN											1	0	0.115264	1	0.115264	3	8									
LCN2	3934	broad.mit.edu	37	9	130911943	130911943	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:130911943G>A	uc004bto.1	+	1	211	c.138_splice	c.e1+1	p.Q46_splice	LCN2_uc010mxq.1_Splice_Site_p.Q46_splice|LCN2_uc011map.1_Splice_Site_p.Q46_splice	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor						apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						GGACAACCAAGTAAGGGGCCA	0.637		NaN											0	0	0	1	0	18	33									
SPTAN1	6709	broad.mit.edu	37	9	131392643	131392643	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:131392643G>A	uc004bvl.3	+	51	6849	c.6736G>A	c.(6736-6738)GAA>AAA	p.E2246K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E2251K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E2226K|SPTAN1_uc004bvo.3_Missense_Mutation_p.E13K|SPTAN1_uc004bvp.3_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2246	Spectrin 23.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATCCCAGCTTGAAGCTACCAA	0.607		NaN											0	0	0	1	0	22	33									
ABL1	25	broad.mit.edu	37	9	133759700	133759700	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:133759700G>A	uc004bzw.2	+	11	2026	c.2023G>A	c.(2023-2025)GAG>AAG	p.E675K	ABL1_uc004bzv.2_Missense_Mutation_p.E694K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	675					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	AGCCCTCCGGGAGTCCGGGGG	0.682		NaN	T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	1	0	20	24									
TSC1	7248	broad.mit.edu	37	9	135781455	135781455	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:135781455C>T	uc004cca.2	-	15	1744	c.1510G>A	c.(1510-1512)GAC>AAC	p.D504N	TSC1_uc004ccb.3_Missense_Mutation_p.D503N|TSC1_uc011mcq.1_Missense_Mutation_p.D453N|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	504					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AAGGGAGAGTCAAAGCCTCCT	0.532		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	1	0	11	23									
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607		NaN											0	0	0	1	0	25	48									
ANAPC2	29882	broad.mit.edu	37	9	140069557	140069557	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:140069557G>A	uc004clr.1	-	13	2379	c.2306C>T	c.(2305-2307)TCA>TTA	p.S769L	ANAPC2_uc004clq.1_Missense_Mutation_p.S625L	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	769					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		ACGATCCAGTGAGAGGCTCTC	0.622		NaN											0	0	0	1	0	3	11									
MRPL41	64975	broad.mit.edu	37	9	140446839	140446839	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:140446839G>A	uc004cnh.3	+	2	436	c.306G>A	c.(304-306)AAG>AAA	p.K102K	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	102					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		CCATCGAAAAGGACTTCAAGG	0.612		NaN											0	0	0	1	0	13	18									
NHS	4810	broad.mit.edu	37	X	17746218	17746218	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:17746218C>G	uc004cxx.2	+	6	4267	c.3929C>G	c.(3928-3930)ACT>AGT	p.T1310S	NHS_uc011mix.1_Missense_Mutation_p.T1331S|NHS_uc004cxy.2_Missense_Mutation_p.T1154S|NHS_uc004cxz.2_Missense_Mutation_p.T1133S|NHS_uc004cya.2_Missense_Mutation_p.T1033S	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1310						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GACTCACCAACTAGAGCAACA	0.443		NaN											0	0	0	1	0	49	20									
ZNF182	7569	broad.mit.edu	37	X	47842407	47842407	+	Silent	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:47842407G>A	uc004dir.2	-	6	577	c.231C>T	c.(229-231)CTC>CTT	p.L77L	ZNF182_uc004dis.2_Silent_p.L58L|ZNF182_uc004dit.2_Silent_p.L77L|ZNF182_uc011mlu.1_Silent_p.L58L	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CCTCCAACTTGAGGATGAGGT	0.463		NaN											0	0	0	1	0	26	4									
DGKK	139189	broad.mit.edu	37	X	50213550	50213550	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:50213550G>A	uc010njr.1	-	1	188	c.128C>T	c.(127-129)CCG>CTG	p.P43L		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	43					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GAgcagcggcggagccggcgg	0.433		NaN											0	0	0	1	0	20	9									
HTATSF1	27336	broad.mit.edu	37	X	135579901	135579901	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:135579901G>A	uc004ezw.2	+	2	480	c.58G>A	c.(58-60)GAA>AAA	p.E20K	HTATSF1_uc004ezx.2_Missense_Mutation_p.E20K	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	20					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCGAATGCAAGAATTGTACGG	0.557		NaN											0	0	0	1	0	39	14									
FUNDC2	65991	broad.mit.edu	37	X	154282927	154282927	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:154282927C>A	uc004fmw.2	+	5	700	c.550C>A	c.(550-552)CTG>ATG	p.L184M		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	184						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGAGGCTTTCTGCTTGGCAT	0.448		NaN											1	0	2.81731e-22	1	2.9685e-22	51	25									
ARID1A	8289	broad.mit.edu	37	1	27056181	27056191	+	Frame_Shift_Del	DEL	CAGCCATATGG	CAGCCATATGG	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			CAGCCATATGG	-	CAGCCATATGG	CAGCCATATGG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:27056181_27056191delCAGCCATATGG	uc001bmv.1	+	2	1550_1560	c.1177_1187delCAGCCATATGG	c.(1177-1188)CAGCCATATGGCfs	p.Q393fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.Q393fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.Q393fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.Q10fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	393_396					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Y395*(1)|p.Q393*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GATGAGACCTCAGCCATATGGCGGGACTAAC	0.545		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								NaN	NaN	NaN	NaN	NaN	22	65	---	---							
IFI44L	10964	broad.mit.edu	37	1	79102839	79102840	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:79102839_79102840insA	uc010oro.1	+	6	1178_1179	c.999_1000insA	c.(997-1002)TCTAAAfs	p.S333fs	IFI44L_uc010orp.1_Frame_Shift_Ins_p.S70fs|IFI44L_uc010orq.1_Frame_Shift_Ins_p.S70fs	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	333_334						cytoplasm					0						ATCTCTACTCTAAAATGTTGGC	0.327		NaN											NaN	NaN	NaN	NaN	NaN	21	52	---	---							
GPR37L1	9283	broad.mit.edu	37	1	202092266	202092267	+	In_Frame_Ins	INS	-	-	ACA			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:202092266_202092267insACA	uc001gxj.2	+	1	238_239	c.175_176insACA	c.(175-177)TAT>TACAAT	p.59_60insN		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	59_60	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						CGTGCAGCAGTATGTGCCTGAG	0.673		NaN											NaN	NaN	NaN	NaN	NaN	14	17	---	---							
PLEKHA6	22874	broad.mit.edu	37	1	204197926	204197926	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204197926delG	uc001hau.2	-	20	3132	c.2815delC	c.(2815-2817)CTGfs	p.L939fs		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	939										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TCAGGGCTCAGGGGAGTGTCA	0.557		NaN											NaN	NaN	NaN	NaN	NaN	15	43	---	---							
MS4A2	2206	broad.mit.edu	37	11	59861476	59861476	+	Frame_Shift_Del	DEL	C	C	-	rs143436537	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:59861476delC	uc001nop.2	+	6	679	c.577delC	c.(577-579)CTTfs	p.L193fs	MS4A2_uc009ymu.2_3'UTR	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	193	Helical; (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	CATTCTGGGACTTGGTAGTGC	0.403		NaN											NaN	NaN	NaN	NaN	NaN	8	36	---	---							
H2AFX	3014	broad.mit.edu	37	11	118965789	118965815	+	In_Frame_Del	DEL	CCTGGGCGATCGTCACGCCGCCCAGCA	CCTGGGCGATCGTCACGCCGCCCAGCA	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:118965789_118965815delCCTGGGCGATCGTCACGCCGCCCAGCA	uc001pvg.2	-	1	363_389	c.290_316delTGCTGGGCGGCGTGACGATCGCCCAGG	c.(289-318)CTGCTGGGCGGCGTGACGATCGCCCAGGGA>CGA	p.97_106LLGGVTIAQG>R	H2AFX_uc001pvh.1_RNA	NM_002105	NP_002096	P16104	H2AX_HUMAN	H2A histone family, member X	97_106					DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		AGGACGCCTCCCTGGGCGATCGTCACGCCGCCCAGCAGCTTGTTGAG	0.692		NaN						Chromatin_Structure|Direct_reversal_of_damage			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	16	76	---	---							
C14orf49	161176	broad.mit.edu	37	14	95912274	95912289	+	Frame_Shift_Del	DEL	CTGTTATGCAGCAGGT	CTGTTATGCAGCAGGT	-	rs28526182	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:95912274_95912289delCTGTTATGCAGCAGGT	uc001yei.3	-	8	1604_1619	c.1589_1604delACCTGCTGCATAACAG	c.(1588-1605)GACCTGCTGCATAACAGCfs	p.D530fs	C14orf49_uc010avi.2_Frame_Shift_Del_p.D530fs|C14orf49_uc001yej.1_Frame_Shift_Del_p.D530fs	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	530_535	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTGCAGGAGGCTGTTATGCAGCAGGTCTCTGTCCCT	0.528		NaN											NaN	NaN	NaN	NaN	NaN	17	33	---	---							
NF1	4763	broad.mit.edu	37	17	29556856	29556866	+	Frame_Shift_Del	DEL	TTATTGACTGA	TTATTGACTGA	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			TTATTGACTGA	-	TTATTGACTGA	TTATTGACTGA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:29556856_29556866delTTATTGACTGA	uc002hgg.2	+	22	3187_3197	c.2854_2864delTTATTGACTGA	c.(2854-2865)TTATTGACTGATfs	p.L952fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L952fs|NF1_uc010csn.1_Frame_Shift_Del_p.L812fs|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	952_955					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCTTTAGGTTTTATTGACTGATACCAATACT	0.37		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			NaN	NaN	NaN	NaN	NaN	23	49	---	---							
EPHX3	79852	broad.mit.edu	37	19	15342144	15342157	+	Frame_Shift_Del	DEL	CAAGTCCACAGCCA	CAAGTCCACAGCCA	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:15342144_15342157delCAAGTCCACAGCCA	uc002nap.2	-	3	589_602	c.380_393delTGGCTGTGGACTTG	c.(379-393)GTGGCTGTGGACTTGfs	p.V127fs	EPHX3_uc002naq.2_Frame_Shift_Del_p.V127fs	NM_024794	NP_079070	Q9H6B9	EPHX3_HUMAN	abhydrolase domain containing 9 precursor	127_131						extracellular region	hydrolase activity				0						CATAGCCTCGCAAGTCCACAGCCACAACATGGAA	0.621		NaN											NaN	NaN	NaN	NaN	NaN	11	49	---	---							
FCHO1	23149	broad.mit.edu	37	19	17877494	17877499	+	In_Frame_Del	DEL	TGGGAG	TGGGAG	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:17877494_17877499delTGGGAG	uc010ebb.2	+	6	400_405	c.211_216delTGGGAG	c.(211-216)TGGGAGdel	p.WE71del	FCHO1_uc002nhg.3_In_Frame_Del_p.WE71del|FCHO1_uc002nhh.2_In_Frame_Del_p.WE71del|FCHO1_uc010xpw.1_In_Frame_Del_p.WE21del|FCHO1_uc010ebc.1_In_Frame_Del_p.WE78del	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	71_72	FCH.									breast(1)	1						CGCCCCGCTCTGGGAGGTCTTCCGCG	0.621		NaN											NaN	NaN	NaN	NaN	NaN	8	20	---	---							
C3orf17	25871	broad.mit.edu	37	3	112724493	112724519	+	In_Frame_Del	DEL	CATGGATGCCTCTAAGATTTTCATGAA	CATGGATGCCTCTAAGATTTTCATGAA	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:112724493_112724519delCATGGATGCCTCTAAGATTTTCATGAA	uc003dzr.2	-	9	1629_1655	c.1568_1594delTTCATGAAAATCTTAGAGGCATCCATG	c.(1567-1596)ATTCATGAAAATCTTAGAGGCATCCATGAA>AAA	p.523_532IHENLRGIHE>K	GTPBP8_uc011bhy.1_Intron|C3orf17_uc003dzq.2_In_Frame_Del_p.148_157IHENLRGIHE>K|C3orf17_uc011bhz.1_In_Frame_Del_p.148_157IHENLRGIHE>K|C3orf17_uc010hqh.2_In_Frame_Del_p.148_157IHENLRGIHE>K|C3orf17_uc003dzt.2_In_Frame_Del_p.426_435IHENLRGIHE>K|C3orf17_uc003dzs.2_In_Frame_Del_p.387_396IHENLRGIHE>K|C3orf17_uc010hqg.2_In_Frame_Del_p.348_357IHENLRGIHE>K|C3orf17_uc011bia.1_In_Frame_Del_p.320_329IHENLRGIHE>K|C3orf17_uc003dzu.2_In_Frame_Del_p.452_461IHENLRGIHE>K|C3orf17_uc011bib.1_In_Frame_Del_p.412_421IHENLRGIHE>K|C3orf17_uc011bic.1_In_Frame_Del_p.356_365IHENLRGIHE>K|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	523_532						integral to membrane					0						GTTTCATTTTCATGGATGCCTCTAAGATTTTCATGAATCATTTTCTC	0.361		NaN											NaN	NaN	NaN	NaN	NaN	26	73	---	---							
MAGEF1	64110	broad.mit.edu	37	3	184429408	184429414	+	Frame_Shift_Del	DEL	CCAAGGC	CCAAGGC	-	rs6770319	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:184429408_184429414delCCAAGGC	uc003fpa.2	-	1	423_429	c.196_202delGCCTTGG	c.(196-204)GCCTTGGCAfs	p.A66fs		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	66_68								p.L67*(1)		ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			CTGCGCCTTGCCAAGGCTTTGGCCGCC	0.681		NaN											NaN	NaN	NaN	NaN	NaN	33	57	---	---							
LRRC66	339977	broad.mit.edu	37	4	52863983	52863983	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:52863983delC	uc003gzi.2	-	3	800	c.787delG	c.(787-789)GCAfs	p.A263fs		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	263						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TGAAAGACTGCCACACTATCA	0.398		NaN											NaN	NaN	NaN	NaN	NaN	9	170	---	---							
PPAP2A	8611	broad.mit.edu	37	5	54721068	54721070	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:54721068_54721070delGTT	uc003jqa.2	-	6	1235_1237	c.819_821delAAC	c.(817-822)ACAACT>ACT	p.273_274TT>T	SKIV2L2_uc003jpy.3_3'UTR|SKIV2L2_uc011cqi.1_3'UTR|PPAP2A_uc003jpz.2_In_Frame_Del_p.274_275TT>T|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	273_274	Cytoplasmic (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GTGATTCCCAGTTGTTGGTGTTT	0.438		NaN											NaN	NaN	NaN	NaN	NaN	30	44	---	---							
G3BP1	10146	broad.mit.edu	37	5	151179821	151179822	+	Frame_Shift_Ins	INS	-	-	GGTGG			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:151179821_151179822insGGTGG	uc003lun.2	+	10	1169_1170	c.998_999insGGTGG	c.(997-999)ATGfs	p.M333fs	G3BP1_uc003lum.2_Frame_Shift_Ins_p.M333fs|G3BP1_uc011dcu.1_Frame_Shift_Ins_p.M151fs|G3BP1_uc010jhz.2_Frame_Shift_Ins_p.M151fs|G3BP1_uc003luq.2_Frame_Shift_Ins_p.M1fs	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	333					Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			CCCCGAAGAATGGTGAGACACC	0.416		NaN											NaN	NaN	NaN	NaN	NaN	14	24	---	---