Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
KCNAB2	8514	broad.mit.edu	37	1	6156774	6156774	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:6156774A>G	uc009vlv.1	+	14	1018	c.883A>G	c.(883-885)ATC>GTC	p.I295V	KCNAB2_uc001alv.1_Missense_Mutation_p.I295V|KCNAB2_uc001alw.1_Missense_Mutation_p.I281V|KCNAB2_uc001alx.1_Missense_Mutation_p.I295V|KCNAB2_uc001aly.1_Missense_Mutation_p.I343V|KCNAB2_uc009vlw.1_Missense_Mutation_p.I228V|KCNAB2_uc001alu.2_Missense_Mutation_p.I295V	NM_003636	NP_003627	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related	295						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGCAGGCCATCGCCGAGCG	0.692		NaN											0	0	0	0.014758	0	5	7									
PLEKHG5	57449	broad.mit.edu	37	1	6529488	6529488	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:6529488C>T	uc001ano.1	-	19	2225	c.2124G>A	c.(2122-2124)CTG>CTA	p.L708L	PLEKHG5_uc001ann.1_Silent_p.L689L|PLEKHG5_uc001anq.1_Silent_p.L729L|PLEKHG5_uc001anp.1_Silent_p.L729L|PLEKHG5_uc001anj.1_Silent_p.L213L|PLEKHG5_uc009vma.1_Silent_p.L492L|PLEKHG5_uc010nzr.1_Silent_p.L721L|PLEKHG5_uc001ank.1_Silent_p.L652L|PLEKHG5_uc009vmb.1_Silent_p.L652L|PLEKHG5_uc001anl.1_Silent_p.L652L|PLEKHG5_uc001anm.1_Silent_p.L652L|PLEKHG5_uc001anr.1_5'Flank	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	708	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GAAACTCATTCAGGTAGATAA	0.592		NaN											0	0	0	0.021022	0	39	140									
SLC45A1	50651	broad.mit.edu	37	1	8385897	8385897	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:8385897G>T	uc001apb.2	+	3	510	c.510G>T	c.(508-510)TCG>TCT	p.S170S		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	170	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGCCTCTCGCTCTTGCTGA	0.597		NaN											1	0	7.93312e-07	0.020292	8.4505e-07	14	60									
GALE	2582	broad.mit.edu	37	1	24124667	24124667	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:24124667C>T	uc009vqo.1	-	4	501	c.291G>A	c.(289-291)TCG>TCA	p.S97S	GALE_uc001bhv.1_Silent_p.S97S|GALE_uc001bhw.1_Silent_p.S97S|GALE_uc001bhx.1_Silent_p.S97S|GALE_uc009vqp.1_Silent_p.S97S|GALE_uc001bhy.1_Silent_p.S97S|GALE_uc001bhz.1_Silent_p.S23S|GALE_uc001bia.2_5'Flank|GALE_uc009vqq.1_3'UTR	NM_001127621	NP_001121093	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	97					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GCTTCTGCACCGACTCGCCCA	0.562		NaN											0	0	0	0.014758	0	5	96									
SEPN1	57190	broad.mit.edu	37	1	26140386	26140386	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:26140386C>T	uc010oer.1	+	14	1457	c.1402C>T	c.(1402-1404)CTC>TTC	p.L468F	SEPN1_uc010oes.1_Missense_Mutation_p.L434F	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	468						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCGGACTCTCCGGGAGAC	0.602		NaN											0	0	0	0.010729	0	11	67									
C1orf38	9473	broad.mit.edu	37	1	28208582	28208582	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:28208582G>A	uc001bpc.3	+	4	775	c.747G>A	c.(745-747)CTG>CTA	p.L249L	C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Silent_p.L249L	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	249	CABIT 2.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTGCTGCTGAGCGAGGTCC	0.637		NaN											0	0	0	0.00499	0	15	46									
ZMYM1	79830	broad.mit.edu	37	1	35580244	35580244	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:35580244G>C	uc001bym.2	+	11	2961	c.2813G>C	c.(2812-2814)AGA>ACA	p.R938T	ZMYM1_uc001byn.2_Missense_Mutation_p.R938T|ZMYM1_uc010ohu.1_Missense_Mutation_p.R919T|ZMYM1_uc001byo.2_Missense_Mutation_p.R578T|ZMYM1_uc009vut.2_Missense_Mutation_p.R863T	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	938						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTCAGAAAAGAAGAAAAATT	0.284		NaN											0	0	0	0.014758	0	4	54									
KCNQ4	9132	broad.mit.edu	37	1	41282936	41282936	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:41282936G>C	uc001cgh.1	+	2	397	c.315_splice	c.e2-1	p.I105_splice	KCNQ4_uc001cgi.1_Splice_Site_p.I105_splice	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein						sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TGTAATTGCAGATTTTTGCTG	0.522		NaN											0	0	0	0.009096	0	4	28									
SLC2A1	6513	broad.mit.edu	37	1	43395392	43395392	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:43395392C>T	uc001cik.2	-	6	1264	c.739G>A	c.(739-741)GAG>AAG	p.E247K		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	247	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TGCCGACTCTCTTCCTTCATC	0.627		NaN											0	0	0	0.01441	0	60	124									
SLC2A1	6513	broad.mit.edu	37	1	43395395	43395395	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:43395395C>T	uc001cik.2	-	6	1261	c.736G>A	c.(736-738)GAA>AAA	p.E246K		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	246	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGACTCTCTTCCTTCATCTCC	0.622		NaN											0	0	0	0.01441	0	61	122									
MMACHC	25974	broad.mit.edu	37	1	45966020	45966020	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:45966020G>T	uc009vxv.2	+	1	165	c.16G>T	c.(16-18)GCA>TCA	p.A6S	CCDC163P_uc001cnt.2_5'Flank|CCDC163P_uc001cnw.2_5'Flank|CCDC163P_uc001cnu.2_5'Flank|CCDC163P_uc009vxt.1_5'Flank|CCDC163P_uc001cnv.2_5'Flank|CCDC163P_uc009vxu.1_5'Flank|MMACHC_uc001cny.2_RNA	NM_015506	NP_056321	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency)	6							cobalamin binding				0	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCGAAAGTCGCAGAGCTGAA	0.512		NaN											1	0	3.52763e-06	0.00499	3.71159e-06	17	131									
SLC5A9	200010	broad.mit.edu	37	1	48701486	48701486	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:48701486C>T	uc001cro.2	+	10	1279	c.1227C>T	c.(1225-1227)TTC>TTT	p.F409F	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Silent_p.F434F|SLC5A9_uc010omt.1_Silent_p.F423F|SLC5A9_uc001crp.2_Silent_p.F76F|SLC5A9_uc010omu.1_Silent_p.F76F	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	409	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						GCACCCTGTTCACCATTGATG	0.612		NaN											0	0	0	0.013726	0	30	48									
ORC1L	4998	broad.mit.edu	37	1	52861995	52861995	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:52861995C>T	uc001ctt.2	-	5	663	c.444G>A	c.(442-444)CTG>CTA	p.L148L	ORC1L_uc010oni.1_Silent_p.L148L|ORC1L_uc001ctu.2_Silent_p.L148L|ORC1L_uc009vzd.2_5'UTR	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	148	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TCTCATTTTTCAGATTCGTCG	0.418		NaN											0	0	0	0.01441	0	63	77									
LEPR	3953	broad.mit.edu	37	1	66083712	66083712	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:66083712C>G	uc001dci.2	+	16	2480	c.2278C>G	c.(2278-2280)CTA>GTA	p.L760V	LEPR_uc001dcg.2_Missense_Mutation_p.L760V|LEPR_uc001dch.2_Missense_Mutation_p.L760V|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.L760V|LEPR_uc001dck.2_Missense_Mutation_p.L760V	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	760	Extracellular (Potential).|Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTCCTGGATACTATCACCCAG	0.318		NaN											0	0	0	0.013537	0	13	55									
ST6GALNAC5	81849	broad.mit.edu	37	1	77516012	77516012	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:77516012G>C	uc001dhi.2	+	4	916	c.741G>C	c.(739-741)AGG>AGC	p.R247S	ST6GALNAC5_uc010ori.1_3'UTR|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	247	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						TCTGTGACAGGATCAATGTTT	0.433		NaN											0	0	0	0.006999	0	40	82									
PIGK	10026	broad.mit.edu	37	1	77629564	77629564	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:77629564G>A	uc001dhk.2	-	6	596	c.551C>T	c.(550-552)GCG>GTG	p.A184V	PIGK_uc010orj.1_Missense_Mutation_p.A108V|PIGK_uc009wbx.2_Missense_Mutation_p.A90V|PIGK_uc001dhl.1_Missense_Mutation_p.A184V	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	184	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						AAAAGCATCCGCGAGTTCTAT	0.308		NaN											0	0	0	0.00499	0	15	40									
RBM15	64783	broad.mit.edu	37	1	110882503	110882503	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:110882503C>G	uc001dzl.1	+	1	559	c.476C>G	c.(475-477)TCA>TGA	p.S159*	RBM15_uc001dzm.1_Nonsense_Mutation_p.S159*|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	159	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCCGCCTCCTCAGCTCCCGGC	0.642		NaN	T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	20	32									
OVGP1	5016	broad.mit.edu	37	1	111957832	111957832	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:111957832C>A	uc001eba.2	-	11	1347	c.1291G>T	c.(1291-1293)GGG>TGG	p.G431W	OVGP1_uc001eaz.2_Missense_Mutation_p.G393W|OVGP1_uc010owb.1_Missense_Mutation_p.G79W	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	431					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCAGTGACCCCAGCCTCTCCT	0.498		NaN											1	0	2.23348e-06	0.004007	2.35718e-06	15	77									
HIST2H2AB	317772	broad.mit.edu	37	1	149859361	149859361	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:149859361G>C	uc001ete.2	-	1	106	c.106C>G	c.(106-108)CGC>GGC	p.R36G	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	36					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTGCCTTTGCGCAGCAAGCGG	0.697		NaN											0	0	0	0.007413	0	20	99									
CGN	57530	broad.mit.edu	37	1	151491799	151491799	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:151491799G>A	uc009wmw.2	+	2	948	c.804G>A	c.(802-804)CAG>CAA	p.Q268Q		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	262	Interacts with ZO-2.|Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTTCTCGTCAGACTCAGGACT	0.552		NaN											0	0	0	0.013537	0	13	31									
TCHH	7062	broad.mit.edu	37	1	152080319	152080319	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:152080319C>G	uc001ezp.2	-	2	5374	c.5374G>C	c.(5374-5376)GAG>CAG	p.E1792Q	TCHH_uc009wne.1_Missense_Mutation_p.E1792Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1792	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCAGACTCTTGGCTGCGC	0.602		NaN											0	0	0	0.021523	0	25	75									
TCHH	7062	broad.mit.edu	37	1	152080442	152080442	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:152080442C>G	uc001ezp.2	-	2	5251	c.5251G>C	c.(5251-5253)GAG>CAG	p.E1751Q	TCHH_uc009wne.1_Missense_Mutation_p.E1751Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1751	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCTTCCTCTAGGATTTTT	0.592		NaN											0	0	0	0.014323	0	23	69									
SHE	126669	broad.mit.edu	37	1	154471660	154471660	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:154471660G>A	uc001ffb.2	-	2	733	c.646C>T	c.(646-648)CAA>TAA	p.Q216*	SHE_uc001ffc.2_RNA	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	216										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCATCCCTTTGACCCTTTGTC	0.453		NaN											0	0	0	0.01892	0	26	62									
FCRL3	115352	broad.mit.edu	37	1	157650526	157650526	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:157650526C>T	uc001frb.2	-	13	2284	c.1992G>A	c.(1990-1992)CAG>CAA	p.Q664Q	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.Q664Q|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.Q390Q|FCRL3_uc001frc.1_Silent_p.Q664Q	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	664	ITIM motif 2.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TGCTCCAGATCTGGGAATAAA	0.433		NaN											0	0	0	0.019004	0	31	53									
CD244	51744	broad.mit.edu	37	1	160808273	160808273	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:160808273C>G	uc009wtq.2	-	5	995	c.817G>C	c.(817-819)GAT>CAT	p.D273H	CD244_uc001fxa.2_Missense_Mutation_p.D268H|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.D176H	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	273	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TCCTTGACATCTTCGTAAATT	0.453		NaN											0	0	0	0.01441	0	140	80									
DEDD	9191	broad.mit.edu	37	1	161094073	161094073	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:161094073G>A	uc001fxz.2	-	3	353	c.180C>T	c.(178-180)CTC>CTT	p.L60L	NIT1_uc001fxw.2_3'UTR|DEDD_uc009wty.2_Silent_p.L60L|DEDD_uc001fya.2_Silent_p.L60L|DEDD_uc001fyb.2_Silent_p.L60L|DEDD_uc010pkb.1_Intron|DEDD_uc001fyc.2_Intron	NM_001039712	NP_001034801	O75618	DEDD_HUMAN	death effector domain-containing protein	60	DED.				apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CATTTCGGATGAGTCCACGCT	0.527		NaN											0	0	0	0.01441	0	64	29									
APOA2	336	broad.mit.edu	37	1	161193191	161193191	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:161193191T>C	uc001fzc.1	-	2	59	c.1A>G	c.(1-3)ATG>GTG	p.M1V	APOA2_uc001fzb.1_RNA|TOMM40L_uc010pkk.1_5'Flank|TOMM40L_uc010pkl.1_5'Flank|TOMM40L_uc001fzd.2_5'Flank|TOMM40L_uc009wue.2_5'Flank|TOMM40L_uc009wuf.1_5'Flank|TOMM40L_uc001fze.2_5'Flank	NM_001643	NP_001634	P02652	APOA2_HUMAN	apolipoprotein A-II preproprotein	1					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGCAGCTTCATGTTGGTAACA	0.582		NaN											0	0	0	0.004482	0	8	40									
PBX1	5087	broad.mit.edu	37	1	164769086	164769086	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:164769086G>A	uc001gct.2	+	4	919	c.661G>A	c.(661-663)GAG>AAG	p.E221K	PBX1_uc010pku.1_Missense_Mutation_p.E221K|PBX1_uc010pkv.1_Missense_Mutation_p.E138K|PBX1_uc001gcs.2_Missense_Mutation_p.E221K|PBX1_uc010pkw.1_Missense_Mutation_p.E111K	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	221					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						GAGCACGTGCGAGGCGGTGAT	0.612		NaN	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								0	0	0	0.004482	0	8	112									
PAPPA2	60676	broad.mit.edu	37	1	176564283	176564283	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:176564283G>T	uc001gkz.2	+	3	2707	c.1543G>T	c.(1543-1545)GGA>TGA	p.G515*	PAPPA2_uc001gky.1_Nonsense_Mutation_p.G515*|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	515	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCAGTACAATGGATACTGGCC	0.537		NaN											1	0	5.50884e-06	0.013537	5.74326e-06	13	118									
PAPPA2	60676	broad.mit.edu	37	1	176659424	176659424	+	Silent	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:176659424A>G	uc001gkz.2	+	5	3453	c.2289A>G	c.(2287-2289)CCA>CCG	p.P763P	PAPPA2_uc001gky.1_Silent_p.P763P|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	763					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGACAGTGCCATCCATGGAAA	0.552		NaN											0	0	0	0.008871	0	19	339									
ZBTB41	360023	broad.mit.edu	37	1	197160945	197160945	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:197160945G>C	uc001gtx.1	-	2	1274	c.1205C>G	c.(1204-1206)TCT>TGT	p.S402C	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	402	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGTTAGGTTAGACTTTGTTGA	0.378		NaN											0	0	0	0.006214	0	10	28									
KDM5B	10765	broad.mit.edu	37	1	202702685	202702685	+	Silent	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:202702685T>A	uc001gyf.2	-	23	3869	c.3753A>T	c.(3751-3753)GCA>GCT	p.A1251A	KDM5B_uc009xag.2_Silent_p.A1287A|KDM5B_uc001gyg.1_Silent_p.A1093A	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1251					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TATATCGAAGTGCATCTCCCT	0.512		NaN											0	0	0	0.016723	0	14	57									
CUBN	8029	broad.mit.edu	37	10	16990556	16990556	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:16990556G>A	uc001ioo.2	-	35	5182	c.5130C>T	c.(5128-5130)AGC>AGT	p.S1710S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1710	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCGTCAGGGCGCTGCTGAAGG	0.512		NaN											0	0	0	0.020292	0	15	25									
ZNF33B	7582	broad.mit.edu	37	10	43088096	43088096	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:43088096G>A	uc001jaf.1	-	5	2417	c.2302C>T	c.(2302-2304)CAG>TAG	p.Q768*	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Nonsense_Mutation_p.Q656*|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	768	C2H2-type 16.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGTGTTCTCTGATGTACAATG	0.398		NaN											0	0	0	0.021523	0	26	175									
CSTF2T	23283	broad.mit.edu	37	10	53457995	53457995	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:53457995C>G	uc001jjp.2	-	1	1361	c.1315G>C	c.(1315-1317)GAG>CAG	p.E439Q	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	439	9 X 5 AA tandem repeats of M-E-T-R-[AG].|Gly-rich.|1-5; approximate.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GCACAGGTCTCCATTCCTCTC	0.537		NaN											0	0	0	0.007413	0	19	66									
FAM13C	220965	broad.mit.edu	37	10	61028376	61028376	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:61028376G>A	uc001jkn.2	-	9	1013	c.879C>T	c.(877-879)ATC>ATT	p.I293I	FAM13C_uc001jko.2_Silent_p.I293I|FAM13C_uc010qid.1_Silent_p.I210I|FAM13C_uc010qie.1_Silent_p.I210I|FAM13C_uc010qif.1_Silent_p.I315I|FAM13C_uc001jkp.2_Silent_p.I210I	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	293										ovary(2)	2						TGAGGCTCTGGATGTGCTTGG	0.498		NaN											0	0	0	0.008291	0	11	24									
PBLD	64081	broad.mit.edu	37	10	70048284	70048284	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:70048284C>G	uc001jns.1	-	8	850	c.647G>C	c.(646-648)AGA>ACA	p.R216T	PBLD_uc001jnr.1_Missense_Mutation_p.R183T|PBLD_uc001jnt.1_Missense_Mutation_p.R216T|PBLD_uc001jnu.1_Missense_Mutation_p.R216T|PBLD_uc001jnv.1_3'UTR	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	216					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TGCAAAATATCTTGAGTAAAA	0.468		NaN											0	0	0	0.003163	0	16	50									
ZMIZ1	57178	broad.mit.edu	37	10	81063832	81063832	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:81063832A>C	uc001kaf.2	+	19	2758	c.2186A>C	c.(2185-2187)GAT>GCT	p.D729A	ZMIZ1_uc001kag.2_Missense_Mutation_p.D605A|ZMIZ1_uc010qlq.1_5'Flank	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	729	SP-RING-type.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AACGGGGAGGATGGGGTGGAG	0.617		NaN											0	0	0	0.006214	0	10	36									
CDHR1	92211	broad.mit.edu	37	10	85973956	85973956	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:85973956C>G	uc001kcv.2	+	17	2159	c.2159C>G	c.(2158-2160)TCC>TGC	p.S720C	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Missense_Mutation_p.S424C|CDHR1_uc001kcx.2_Missense_Mutation_p.S34C	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	720	Helical; (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						GTCCTCATCTCCACCGCCACC	0.637		NaN											0	0	0	0.006122	0	18	59									
IFIT3	3437	broad.mit.edu	37	10	91099693	91099693	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:91099693G>A	uc001kgf.2	+	2	1510	c.1281G>A	c.(1279-1281)CAG>CAA	p.Q427Q	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Silent_p.Q427Q	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	427	TPR 7.				type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						TTCATAAGCAGAATGGAGATC	0.433		NaN											0	0	0	0.00308	0	8	51									
C10orf76	79591	broad.mit.edu	37	10	103649229	103649229	+	Silent	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:103649229A>G	uc009xwy.1	-	24	1902	c.1800T>C	c.(1798-1800)TTT>TTC	p.F600F	C10orf76_uc009xwx.1_RNA	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	600						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTTTGGGGTTAAAGTGGTTGA	0.428		NaN											0	0	0	0.01441	0	51	180									
PSD	5662	broad.mit.edu	37	10	104174879	104174879	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:104174879C>T	uc001kvg.1	-	4	1392	c.865G>A	c.(865-867)GAC>AAC	p.D289N	PSD_uc001kvh.1_5'UTR|PSD_uc009xxd.1_Missense_Mutation_p.D289N	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	289					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGCACCGTGTCCAGGTCTGTC	0.672		NaN											0	0	0	0.00308	0	8	43									
TRUB1	142940	broad.mit.edu	37	10	116732026	116732026	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:116732026C>T	uc001lcd.2	+	6	790	c.729C>T	c.(727-729)TTC>TTT	p.F243F	TRUB1_uc010qsl.1_Silent_p.F145F	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	243					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		CACCATTTTTCACATTAGGTA	0.358		NaN											0	0	0	0.009535	0	30	52									
PNLIP	5406	broad.mit.edu	37	10	118306905	118306905	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:118306905A>G	uc001lcm.2	+	3	189	c.146A>G	c.(145-147)AAA>AGA	p.K49R		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	49					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGGTCTCCAAAAGATGTCAAC	0.398		NaN											0	0	0	0.008291	0	11	65									
WDR11	55717	broad.mit.edu	37	10	122626260	122626260	+	Silent	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:122626260C>A	uc010qtf.1	+	8	1412	c.1174C>A	c.(1174-1176)CGA>AGA	p.R392R	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	392	WD 3.					integral to membrane					0						AGTTTGTAATCGAAATTCACG	0.393		NaN											1	0	2.81731e-10	0.010818	3.06774e-10	31	56									
C10orf88	80007	broad.mit.edu	37	10	124708192	124708192	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:124708192C>T	uc001lgw.2	-	4	846	c.621G>A	c.(619-621)TTG>TTA	p.L207L	C10orf88_uc001lgx.2_Silent_p.L109L	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	207											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		CCATATCCATCAACTGCTGAG	0.413		NaN											0	0	0	0.006214	0	10	42									
MGMT	4255	broad.mit.edu	37	10	131565235	131565235	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:131565235G>T	uc001lkh.2	+	5	717	c.691G>T	c.(691-693)GGC>TGC	p.G231C		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	200										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		AGCTACCTCGGGCTCCCCGCC	0.637		NaN						Direct_reversal_of_damage					1	0	5.18039e-06	0.00308	5.4173e-06	8	17									
TRIM68	55128	broad.mit.edu	37	11	4623543	4623543	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:4623543C>T	uc001lzf.1	-	4	860	c.622G>A	c.(622-624)GAG>AAG	p.E208K	TRIM68_uc001lzg.1_5'UTR|TRIM68_uc010qyj.1_RNA|TRIM68_uc009yek.1_Missense_Mutation_p.E208K	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	208	Potential.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCTGCTACCTCTGCCCCCAGC	0.537		NaN											0	0	0	0.00499	0	18	24									
OR51G1	79324	broad.mit.edu	37	11	4944672	4944672	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:4944672G>T	uc010qyr.1	-	1	898	c.898C>A	c.(898-900)CAA>AAA	p.Q300K		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCGAATTTGCTTGGTCTTG	0.423		NaN											1	0	0.000308642	0.003163	0.000316013	16	42									
MICAL2	9645	broad.mit.edu	37	11	12231097	12231097	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:12231097G>C	uc001mjz.2	+	6	931	c.643G>C	c.(643-645)GAG>CAG	p.E215Q	MICAL2_uc010rch.1_Missense_Mutation_p.E215Q|MICAL2_uc001mka.2_Missense_Mutation_p.E215Q|MICAL2_uc010rci.1_Missense_Mutation_p.E215Q|MICAL2_uc001mkb.2_Missense_Mutation_p.E215Q|MICAL2_uc001mkc.2_Missense_Mutation_p.E215Q|MICAL2_uc001mkd.2_Missense_Mutation_p.E44Q	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	215						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GTCGGAGTTTGAGTTTGACGT	0.532		NaN											0	0	0	0.00632	0	29	33									
LGR4	55366	broad.mit.edu	37	11	27405924	27405924	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:27405924C>G	uc001mrj.3	-	6	1133	c.648G>C	c.(646-648)CTG>CTC	p.L216L	LGR4_uc001mrk.3_Silent_p.L192L	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	216	LRR 7.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						AGTGTTGACTCAGGCTTCTAA	0.323		NaN											0	0	0	0.010818	0	32	42									
KCNA4	3739	broad.mit.edu	37	11	30032651	30032651	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:30032651C>G	uc001msk.2	-	2	2727	c.1575G>C	c.(1573-1575)GTG>GTC	p.V525V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	525	Selectivity filter (By similarity).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCCATAGCCCACAGTTGTCA	0.517		NaN											0	0	0	0.016723	0	14	40									
TRAF6	7189	broad.mit.edu	37	11	36512195	36512195	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:36512195C>T	uc001mwr.1	-	8	1102	c.762G>A	c.(760-762)CAG>CAA	p.Q254Q	TRAF6_uc001mws.1_Silent_p.Q254Q	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	254	Interaction with TAX1BP1.|TRAF-type 2.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				AGTGATTCCTCTGCATCTAAA	0.473		NaN											0	0	0	0.00632	0	28	57									
OR5D18	219438	broad.mit.edu	37	11	55587908	55587908	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:55587908C>G	uc010rin.1	+	1	803	c.803C>G	c.(802-804)TCC>TGC	p.S268C		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCCAAAAACTCCAGGCACACA	0.507		NaN											0	0	0	0.008361	0	32	59									
OR10AG1	282770	broad.mit.edu	37	11	55735793	55735793	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:55735793G>A	uc010rit.1	-	1	147	c.147C>T	c.(145-147)CCC>CCT	p.P49P		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	49	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AAAAATACATGGGAGTCTGGA	0.333		NaN											0	0	0	0.01441	0	48	54									
TNKS1BP1	85456	broad.mit.edu	37	11	57069342	57069342	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57069342G>A	uc001njr.2	-	8	5222	c.4910C>T	c.(4909-4911)TCG>TTG	p.S1637L	TNKS1BP1_uc001njp.2_Missense_Mutation_p.S209L|TNKS1BP1_uc001njq.2_Missense_Mutation_p.S210L|TNKS1BP1_uc001njs.2_Missense_Mutation_p.S1637L	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1637	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GGTGCCCAACGACATCCGTGT	0.582		NaN											0	0	0	0.009096	0	4	56									
PRG3	10394	broad.mit.edu	37	11	57147185	57147185	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57147185T>A	uc001njv.1	-	3	267	c.157A>T	c.(157-159)ACG>TCG	p.T53S		NM_006093	NP_006084	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3 precursor	53					basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding				0						ACCTCCTCCGTCAGAGCCAAG	0.562		NaN											0	0	0	0.004656	0	26	82									
OR10Q1	219960	broad.mit.edu	37	11	57995510	57995510	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57995510C>T	uc010rkd.1	-	1	838	c.838G>A	c.(838-840)GCG>ACG	p.A280T		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				TAGACCAACGCGATTTGGCTG	0.547		NaN											0	0	0	0.014323	0	23	118									
PLAC1L	219990	broad.mit.edu	37	11	59807984	59807984	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:59807984G>A	uc001nol.2	+	1	237	c.52G>A	c.(52-54)GAG>AAG	p.E18K		NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor	18						extracellular region				ovary(2)|skin(1)	3						GACCGGTGCTGAGAACCTCCA	0.458		NaN											0	0	0	0.012213	0	31	79									
TMEM132A	54972	broad.mit.edu	37	11	60695278	60695278	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:60695278C>T	uc001nqj.2	+	3	674	c.481C>T	c.(481-483)CGG>TGG	p.R161W	TMEM132A_uc001nqi.2_Missense_Mutation_p.R161W|TMEM132A_uc001nqk.2_Missense_Mutation_p.R174W|TMEM132A_uc001nql.1_Missense_Mutation_p.R174W	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	161	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						GCCCTGTGCCCGGCTCCATGC	0.652		NaN											0	0	0	0.021523	0	26	45									
NPAS4	266743	broad.mit.edu	37	11	66190264	66190264	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:66190264G>T	uc001ohx.1	+	4	726	c.550G>T	c.(550-552)GGA>TGA	p.G184*	NPAS4_uc010rpc.1_Missense_Mutation_p.Q10H	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	184					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTACTGGGCAGGAAATCCCGT	0.622		NaN											1	0	2.98393e-07	0.016522	3.1984e-07	25	97									
NPAS4	266743	broad.mit.edu	37	11	66191516	66191516	+	Silent	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:66191516T>C	uc001ohx.1	+	7	1331	c.1155T>C	c.(1153-1155)TCT>TCC	p.S385S	NPAS4_uc010rpc.1_Silent_p.S175S	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	385					transcription, DNA-dependent		DNA binding|signal transducer activity				0						GTGTTGTCTCTGCATCAGAAG	0.562		NaN											0	0	0	0.007291	0	31	193									
CABP4	57010	broad.mit.edu	37	11	67222934	67222934	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:67222934C>G	uc001olo.2	+	1	117	c.40C>G	c.(40-42)CTG>GTG	p.L14V	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	14					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GGGCCCAAATCTGGCCATTGG	0.632		NaN											0	0	0	0.001168	0	5	5									
UNC93B1	81622	broad.mit.edu	37	11	67766749	67766749	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:67766749G>C	uc001omw.1	-	5	661	c.581C>G	c.(580-582)TCC>TGC	p.S194C		NM_030930	NP_112192	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1	194					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome					0						CTTGTAGTGGGAGTACTCATG	0.612		NaN											0	0	0	0.004007	0	17	17									
ARHGEF17	9828	broad.mit.edu	37	11	73066945	73066945	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:73066945G>A	uc001otu.2	+	5	3631	c.3610G>A	c.(3610-3612)GAC>AAC	p.D1204N		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1204	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGCGCTGTCTGACCTCATGAT	0.567		NaN											0	0	0	0.010818	0	28	99									
ARHGEF17	9828	broad.mit.edu	37	11	73067780	73067780	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:73067780G>A	uc001otu.2	+	7	3888	c.3867G>A	c.(3865-3867)CTG>CTA	p.L1289L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1289					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGCGGTTCCTGAGACAGGAGA	0.552		NaN											0	0	0	0.004482	0	7	35									
UVRAG	7405	broad.mit.edu	37	11	75852128	75852128	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:75852128G>A	uc001oxc.2	+	15	2012	c.1771G>A	c.(1771-1773)GGG>AGG	p.G591R	UVRAG_uc010rrw.1_Missense_Mutation_p.G490R|UVRAG_uc001oxd.2_Missense_Mutation_p.G219R|UVRAG_uc010rrx.1_Missense_Mutation_p.G219R|UVRAG_uc010rry.1_Missense_Mutation_p.G147R	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	591					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						AGCCCTCTCCGGGCACCGGGC	0.577		NaN											0	0	0	0.004482	0	9	28									
EED	8726	broad.mit.edu	37	11	85977208	85977209	+	Missense_Mutation	DNP	GA	GA	CT			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:85977208_85977209GA>CT	uc001pbp.2	+	8	1267_1268	c.810_811GA>CT	c.(808-813)ATGATG>ATCTTG	p.270_271MM>IL	EED_uc010rtm.1_Missense_Mutation_p.270_271MM>IL|EED_uc001pbq.2_Missense_Mutation_p.270_271MM>IL|EED_uc001pbr.2_Missense_Mutation_p.270_271MM>IL|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	270_271	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				CAAAGAGAATGATGAATGCAAT	0.302		NaN											0	0	0	0.004672	0	13	85									
TRPC6	7225	broad.mit.edu	37	11	101347251	101347251	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:101347251C>T	uc001pgk.3	-	6	1950	c.1525G>A	c.(1525-1527)GAA>AAA	p.E509K	TRPC6_uc009ywy.2_Missense_Mutation_p.E393K|TRPC6_uc009ywz.1_Missense_Mutation_p.E454K	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	509	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TCTTTACATTCAGCCCATATC	0.378		NaN											0	0	0	0.021523	0	25	27									
OR8A1	390275	broad.mit.edu	37	11	124440753	124440753	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:124440753C>T	uc010san.1	+	1	789	c.789C>T	c.(787-789)GCC>GCT	p.A263A		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	263	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		ACCTTGCAGCCGTGGGAATGT	0.507		NaN											0	0	0	0.007291	0	28	31									
RPUSD4	84881	broad.mit.edu	37	11	126081382	126081382	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:126081382C>T	uc001qde.2	-	1	206	c.152G>A	c.(151-153)CGA>CAA	p.R51Q	FAM118B_uc001qdf.2_5'Flank|FAM118B_uc009zca.2_5'Flank|FAM118B_uc001qdg.2_5'Flank|RPUSD4_uc009zbz.2_Missense_Mutation_p.R51Q|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	51	Potential.				pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		TTTCTGGGCTCGGAGCTTCTC	0.567		NaN											0	0	0	0.01441	0	61	80									
ATF7IP	55729	broad.mit.edu	37	12	14589126	14589126	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:14589126G>A	uc001rbw.2	+	4	1890	c.1732G>A	c.(1732-1734)GAG>AAG	p.E578K	ATF7IP_uc010shs.1_Missense_Mutation_p.E577K|ATF7IP_uc001rbu.2_Missense_Mutation_p.E578K|ATF7IP_uc001rbv.1_Missense_Mutation_p.E577K|ATF7IP_uc001rbx.2_Missense_Mutation_p.E577K|ATF7IP_uc010sht.1_Missense_Mutation_p.E578K|ATF7IP_uc001rby.3_Missense_Mutation_p.E578K|ATF7IP_uc001rca.2_Missense_Mutation_p.E578K	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	578	Interaction with SETDB1.|Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						AGAAGAATATGAGGCAGAATT	0.323		NaN											0	0	0	0.012213	0	31	51									
SLCO1B3	28234	broad.mit.edu	37	12	21229431	21229431	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:21229431C>T	uc010sil.1	+	15	2041	c.1976C>T	c.(1975-1977)ACG>ATG	p.T659M	LST-3TM12_uc010sim.1_Missense_Mutation_p.T598M|LST-3TM12_uc010sin.1_Missense_Mutation_p.T551M			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ATTGATACAACGTGTATGAAG	0.363		NaN											0	0	0	0.007291	0	29	84									
KIAA0528	9847	broad.mit.edu	37	12	22646159	22646159	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:22646159G>C	uc001rfq.2	-	11	1488	c.1260C>G	c.(1258-1260)ATC>ATG	p.I420M	KIAA0528_uc010sir.1_Missense_Mutation_p.I235M|KIAA0528_uc010sis.1_Missense_Mutation_p.I420M|KIAA0528_uc010sit.1_Missense_Mutation_p.I422M|KIAA0528_uc010siu.1_Missense_Mutation_p.I420M|KIAA0528_uc001rfr.2_Missense_Mutation_p.I411M|KIAA0528_uc009ziy.1_Missense_Mutation_p.I422M	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	420							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TCATTTACCAGATGCTAGTTG	0.363		NaN											0	0	0	0.004007	0	17	92									
PPFIBP1	8496	broad.mit.edu	37	12	27787986	27787986	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:27787986T>A	uc001ric.1	+	4	585	c.208T>A	c.(208-210)TTG>ATG	p.L70M	PPFIBP1_uc001rhy.1_Missense_Mutation_p.L70M|PPFIBP1_uc001rhz.1_Missense_Mutation_p.L70M|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.L70M|PPFIBP1_uc001ria.2_Missense_Mutation_p.L70M|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	70					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					GAAAGAAGGCTTGAGATGCCA	0.458		NaN											0	0	0	0.020292	0	13	64									
CNTN1	1272	broad.mit.edu	37	12	41421762	41421762	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:41421762G>T	uc001rmm.1	+	22	2927	c.2814G>T	c.(2812-2814)ACG>ACT	p.T938T	CNTN1_uc001rmn.1_Silent_p.T927T	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	938	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CTACAGTGACGGGATATAAGG	0.348		NaN											1	0	1.5739e-10	0.004007	1.71926e-10	16	37									
ARID2	196528	broad.mit.edu	37	12	46244661	46244661	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:46244661C>G	uc001ros.1	+	15	2755	c.2755C>G	c.(2755-2757)CAG>GAG	p.Q919E	ARID2_uc001ror.2_Missense_Mutation_p.Q919E|ARID2_uc009zkg.1_Missense_Mutation_p.Q375E|ARID2_uc009zkh.1_Missense_Mutation_p.Q546E|ARID2_uc001rou.1_Missense_Mutation_p.Q253E	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	919	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCAACAACCACAGCAGCCAAC	0.473		NaN											0	0	0	0.006122	0	17	123									
CCNT1	904	broad.mit.edu	37	12	49087819	49087819	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:49087819C>A	uc001rse.1	-	9	1501	c.1178G>T	c.(1177-1179)CGC>CTC	p.R393L	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.R108L	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	393	Potential.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						ATGCTTCGCGCGGTATTCTTT	0.448		NaN											1	0	3.99451e-17	0.009535	4.49218e-17	32	160									
KRT5	3852	broad.mit.edu	37	12	52910468	52910468	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:52910468G>A	uc001san.2	-	7	1555	c.1392C>T	c.(1390-1392)GAC>GAT	p.D464D	KRT5_uc009zmh.2_Silent_p.D464D	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	464	Rod.|Coil 2.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		CGATCTCCACGTCCAGGGCCA	0.602		NaN											0	0	0	0.007291	0	30	105									
ERBB3	2065	broad.mit.edu	37	12	56477672	56477672	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:56477672C>T	uc001sjh.2	+	2	413	c.220C>T	c.(220-222)CTC>TTC	p.L74F	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.L15F|ERBB3_uc001sjg.2_Missense_Mutation_p.L74F	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	74	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAATGCCGACCTCTCCTTCCT	0.537		NaN											0	0	0	0.005443	0	27	71									
LRP1	4035	broad.mit.edu	37	12	57548325	57548325	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:57548325G>T	uc001snd.2	+	8	1534	c.1068G>T	c.(1066-1068)CAG>CAT	p.Q356H	LRP1_uc001snc.1_Missense_Mutation_p.Q356H	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	356	LDL-receptor class B 2.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGATGGGCAGAACCGCACCA	0.527		NaN											1	0	2.17888e-05	0.006214	2.25107e-05	10	27									
CYP27B1	1594	broad.mit.edu	37	12	58158842	58158842	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:58158842C>A	uc001spz.1	-	4	894	c.742G>T	c.(742-744)GGG>TGG	p.G248W	CYP27B1_uc001sqa.1_Missense_Mutation_p.G13W|CYP27B1_uc001sqb.1_Missense_Mutation_p.W128L|CYP27B1_uc001sqc.1_Missense_Mutation_p.W128L	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	248					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CCCCAGGGCCCAGGCACAAGG	0.622		NaN									OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	7.93312e-07	0.020292	8.4505e-07	13	54									
SLC6A15	55117	broad.mit.edu	37	12	85266933	85266933	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:85266933C>A	uc001szv.2	-	7	1535	c.1042G>T	c.(1042-1044)GCA>TCA	p.A348S	SLC6A15_uc010sul.1_Missense_Mutation_p.A241S|SLC6A15_uc001szw.1_Missense_Mutation_p.A56S	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	348	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ACCAATGTTGCCAGGACAGAA	0.393		NaN											1	0	0.00307968	0.00308	0.00313451	8	56									
RASSF9	9182	broad.mit.edu	37	12	86199049	86199049	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:86199049G>T	uc001taf.1	-	2	1078	c.739C>A	c.(739-741)CTA>ATA	p.L247I		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	247	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TGCAAGTCTAGATTTTGCTCA	0.403		NaN											1	0	1.01871e-10	0.008871	1.11635e-10	19	85									
NTS	4922	broad.mit.edu	37	12	86272172	86272172	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:86272172G>T	uc001tag.2	+	3	292	c.185G>T	c.(184-186)TGC>TTC	p.C62F		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	62					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						CTAAATGTTTGCAGTCTTGTA	0.358		NaN											1	0	1.50039e-11	0.012319	1.65477e-11	21	107									
TCP11L2	255394	broad.mit.edu	37	12	106712230	106712230	+	Silent	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:106712230A>G	uc001tln.2	+	4	576	c.402A>G	c.(400-402)GAA>GAG	p.E134E	TCP11L2_uc001tll.2_Silent_p.E134E|TCP11L2_uc001tlm.2_Silent_p.E134E	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	134										ovary(3)	3						AACTGTTTGAAGAAATCAGAG	0.328		NaN											0	0	0	0.003163	0	15	46									
ACACB	32	broad.mit.edu	37	12	109654448	109654448	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:109654448A>G	uc001tob.2	+	23	3495	c.3376A>G	c.(3376-3378)ATG>GTG	p.M1126V	ACACB_uc001toc.2_Missense_Mutation_p.M1126V	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1126					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CCGCGGCTATATGAAAACAGT	0.473		NaN											0	0	0	0.006214	0	10	32									
RASAL1	8437	broad.mit.edu	37	12	113554886	113554886	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:113554886C>T	uc001tum.1	-	9	1016	c.723G>A	c.(721-723)GAG>GAA	p.E241E	RASAL1_uc010syp.1_Silent_p.E241E|RASAL1_uc001tul.2_Silent_p.E241E|RASAL1_uc001tun.1_Silent_p.E241E|RASAL1_uc010syq.1_Silent_p.E241E|RASAL1_uc001tuo.3_Silent_p.E241E|RASAL1_uc010syr.1_Silent_p.E241E	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	241					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						ACCCAGAATCCTCCTCGGCTC	0.607		NaN											0	0	0	0.001984	0	6	24									
TBX5	6910	broad.mit.edu	37	12	114823367	114823367	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:114823367C>T	uc001tvo.2	-	7	1164	c.669G>A	c.(667-669)ACG>ACA	p.T223T	TBX5_uc001tvp.2_Silent_p.T223T|TBX5_uc001tvq.2_Silent_p.T173T|TBX5_uc010syv.1_Silent_p.T223T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	223	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCTTTAATTGCGTGATCTGAA	0.418		NaN											0	0	0	0.014758	0	5	23									
DNAH10	196385	broad.mit.edu	37	12	124352470	124352470	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:124352470G>T	uc001uft.3	+	42	6994	c.6969G>T	c.(6967-6969)ATG>ATT	p.M2323I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2323					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAGCCAAGATGTTGGATGCGT	0.512		NaN											1	0	0.00010058	0.013537	0.0001036	11	14									
FAM101A	144347	broad.mit.edu	37	12	124798930	124798930	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:124798930C>G	uc001ugd.1	+	3	510	c.267C>G	c.(265-267)ATC>ATG	p.I89M	FAM101A_uc001uge.1_Missense_Mutation_p.I89M	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	170											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CCACCATCATCTTCCCCAAGC	0.687		NaN											0	0	0	0.008361	0	28	40									
TMEM132D	121256	broad.mit.edu	37	12	130184385	130184385	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:130184385C>G	uc009zyl.1	-	2	1266	c.938G>C	c.(937-939)AGA>ACA	p.R313T		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	313	Extracellular (Potential).					integral to membrane		p.R313G(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGTGGAATTTCTGGAGATGGA	0.502		NaN											0	0	0	0.00308	0	6	39									
N4BP2L2	10443	broad.mit.edu	37	13	33018121	33018121	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:33018121C>G	uc010abe.1	-	7	575	c.553G>C	c.(553-555)GAT>CAT	p.D185H	N4BP2L2_uc001uug.2_Missense_Mutation_p.D68H|N4BP2L2_uc010abd.1_Missense_Mutation_p.D98H|N4BP2L2_uc001uuh.2_Missense_Mutation_p.D16H|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.D170H	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GGGTCCTGATCTCCCGGTGTA	0.383		NaN											0	0	0	0.009096	0	4	9									
KBTBD7	84078	broad.mit.edu	37	13	41766515	41766515	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:41766515G>A	uc001uxw.1	-	1	2188	c.1879C>T	c.(1879-1881)CAG>TAG	p.Q627*	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	627							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		ATAAAACTCTGACCAGGTTCA	0.438		NaN											0	0	0	0.009535	0	33	74									
SLC15A1	6564	broad.mit.edu	37	13	99337111	99337111	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:99337111A>G	uc001vno.2	-	23	2071	c.1994T>C	c.(1993-1995)ATC>ACC	p.I665T		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	665	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCGAGCCATGATGGCAAAAAT	0.413		NaN											0	0	0	0.001984	0	6	45									
MYO16	23026	broad.mit.edu	37	13	109817341	109817341	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:109817341G>A	uc001vqt.1	+	33	5317	c.5191G>A	c.(5191-5193)GGA>AGA	p.G1731R	MYO16_uc010agk.1_Missense_Mutation_p.G1753R	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1731					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AAATAACCATGGAATTCAGTT	0.338		NaN											0	0	0	0.001168	0	5	69									
CDC16	8881	broad.mit.edu	37	13	115037904	115037904	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:115037904G>C	uc001vuk.1	+	18	2047	c.1849G>C	c.(1849-1851)GAC>CAC	p.D617H	CDC16_uc001vul.1_Missense_Mutation_p.D617H|CDC16_uc001vum.1_Missense_Mutation_p.D523H|CDC16_uc001vun.1_Missense_Mutation_p.D616H|CDC16_uc001vuo.1_Missense_Mutation_p.D565H	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6	617					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			ATCTATGTCAGACCACAGCAC	0.453		NaN											0	0	0	0.005524	0	36	17									
OR4K17	390436	broad.mit.edu	37	14	20586060	20586060	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:20586060C>T	uc001vwo.1	+	1	495	c.495C>T	c.(493-495)ACC>ACT	p.T165T		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ACTACATGACCATCATGAACA	0.453		NaN											0	0	0	0.008291	0	11	95									
OR11H4	390442	broad.mit.edu	37	14	20711554	20711554	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:20711554G>T	uc010tld.1	+	1	604	c.604G>T	c.(604-606)GCT>TCT	p.A202S		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	202	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CTGTGCCCCAGCTCCCATAAC	0.433		NaN											1	0	2.01871e-26	0.01441	2.28521e-26	66	98									
FUT8	2530	broad.mit.edu	37	14	66136117	66136117	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:66136117A>G	uc001xin.2	+	7	1951	c.754A>G	c.(754-756)ACT>GCT	p.T252A	FUT8_uc001xio.2_Missense_Mutation_p.T252A|FUT8_uc010tsp.1_Missense_Mutation_p.T89A|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.T252A|FUT8_uc001xiq.2_Missense_Mutation_p.T123A|FUT8_uc001xis.2_5'Flank	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	252	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		GCGCTATGCTACTGGTGGATG	0.502		NaN											0	0	0	0.006214	0	10	48									
OR4M2	390538	broad.mit.edu	37	15	22368693	22368693	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:22368693C>A	uc010tzu.1	+	1	118	c.118C>A	c.(118-120)CCA>ACA	p.P40T	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GTTCATCCTACCAGGAAATAT	0.418		NaN											1	0	1.62957e-23	0.00874	1.83863e-23	44	389									
C15orf2	23742	broad.mit.edu	37	15	24921968	24921968	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:24921968C>G	uc001ywo.2	+	1	1428	c.954C>G	c.(952-954)CCC>CCG	p.P318P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	318	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTGCTCCTCCCAGAGCTGCCC	0.587		NaN											0	0	0	0.001168	0	6	50									
MAPKBP1	23005	broad.mit.edu	37	15	42113042	42113042	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:42113042G>A	uc001zok.3	+	24	2798	c.2512G>A	c.(2512-2514)GTG>ATG	p.V838M	MAPKBP1_uc001zoj.3_Missense_Mutation_p.V832M|MAPKBP1_uc010bcj.2_Missense_Mutation_p.V339M|MAPKBP1_uc010bci.2_Missense_Mutation_p.V832M|MAPKBP1_uc010udb.1_Missense_Mutation_p.V671M|MAPKBP1_uc010bck.2_Missense_Mutation_p.V49M|MAPKBP1_uc010bcl.2_Missense_Mutation_p.V339M	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	838										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ACAGGAGTCCGTGGGGTTCCT	0.488		NaN											0	0	0	0.001168	0	6	13									
SCAPER	49855	broad.mit.edu	37	15	76995205	76995205	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:76995205G>C	uc002bby.2	-	18	2445	c.2386C>G	c.(2386-2388)CTC>GTC	p.L796V	SCAPER_uc010bkr.2_Missense_Mutation_p.L104V|SCAPER_uc002bbx.2_Missense_Mutation_p.L550V|SCAPER_uc002bbz.1_Missense_Mutation_p.L667V|SCAPER_uc002bca.1_Missense_Mutation_p.L661V|SCAPER_uc002bcb.1_Missense_Mutation_p.L802V	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	795	C2H2-type.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						ACATTGCAGAGAGAACACTGC	0.358		NaN											0	0	0	0.00499	0	17	70									
ALPK3	57538	broad.mit.edu	37	15	85382285	85382285	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:85382285G>A	uc002ble.2	+	4	1152	c.985G>A	c.(985-987)GAG>AAG	p.E329K		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	329	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCAAAATATGAGATCACTCA	0.572		NaN											0	0	0	0.010729	0	12	10									
CHD2	1106	broad.mit.edu	37	15	93563489	93563489	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:93563489G>A	uc002bsp.2	+	38	5728	c.5153_splice	c.e38+1	p.R1718_splice	CHD2_uc002bso.1_Silent_p.R1718R	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATTATGACAGGTATGCAAAAG	0.463		NaN											0	0	0	0.00499	0	17	26									
PCSK6	5046	broad.mit.edu	37	15	101938656	101938656	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:101938656C>A	uc002bwy.2	-	8	1263	c.949G>T	c.(949-951)GGG>TGG	p.G317W	PCSK6_uc010bpd.2_Missense_Mutation_p.G187W|PCSK6_uc010bpe.2_Missense_Mutation_p.G317W|PCSK6_uc002bxa.2_Missense_Mutation_p.G317W|PCSK6_uc002bxb.2_Missense_Mutation_p.G317W|PCSK6_uc002bxc.1_Missense_Mutation_p.G317W|PCSK6_uc002bxd.1_Missense_Mutation_p.G317W|PCSK6_uc002bxe.2_Missense_Mutation_p.G317W|PCSK6_uc002bxg.1_Missense_Mutation_p.G317W	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	317	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CGGCCGGGCCCGTCCACCGTC	0.582		NaN											1	0	6.94344e-10	0.006122	7.53671e-10	15	111									
SSTR5	6755	broad.mit.edu	37	16	1129228	1129228	+	Silent	SNP	C	C	T	rs35742768	byFrequency	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:1129228C>T	uc002ckq.2	+	1	448	c.360C>T	c.(358-360)GGC>GGT	p.G120G	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	120	Helical; Name=3; (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCTGGACGGCGTCAACCAGT	0.677		NaN											0	0	0	0.014758	0	4	38									
RPL3L	6123	broad.mit.edu	37	16	1996698	1996698	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:1996698C>T	uc002cnh.2	-	7	926	c.879G>A	c.(877-879)ATG>ATA	p.M293I		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	293					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						TCCCGTCCTCCATGTGCGGGC	0.652		NaN											0	0	0	0.004482	0	9	30									
MEFV	4210	broad.mit.edu	37	16	3298929	3298929	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:3298929C>G	uc002cun.1	-	4	1376	c.1336G>C	c.(1336-1338)GAG>CAG	p.E446Q		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	446					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	ACTGCCTTCTCCTCCCCATAG	0.532		NaN											0	0	0	0.007413	0	20	128									
ZC3H7A	29066	broad.mit.edu	37	16	11850213	11850213	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:11850213C>T	uc002dbk.2	-	20	2640	c.2442G>A	c.(2440-2442)GAG>GAA	p.E814E	ZC3H7A_uc002dbi.2_Silent_p.E2E|ZC3H7A_uc002dbj.2_RNA|ZC3H7A_uc002dbl.2_Silent_p.E814E|ZC3H7A_uc002dbm.1_Silent_p.E724E	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	814						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						CGTAAAATTGCTCCATATCTT	0.338		NaN											0	0	0	0.016723	0	14	35									
ZP2	7783	broad.mit.edu	37	16	21211121	21211121	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:21211121C>T	uc002dii.2	-	15	1773	c.1773G>A	c.(1771-1773)CAG>CAA	p.Q591Q	ZP2_uc010bwn.1_Silent_p.Q621Q	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	591	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		TGTCAAACCTCTGATAGTGAT	0.502		NaN											0	0	0	0.014323	0	22	39									
DPEP2	64174	broad.mit.edu	37	16	68021779	68021779	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:68021779C>T	uc010cey.2	-	9	1346	c.1182G>A	c.(1180-1182)CTG>CTA	p.L394L	DPEP2_uc002evd.3_Silent_p.L399L|DPEP2_uc002eve.2_Silent_p.L394L|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	394					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TGAAGACCCGCAGCAGGTTTC	0.567		NaN											0	0	0	0.009535	0	30	186									
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	G	A	rs28934573		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:7577559G>A	uc002gim.2	-	7	916	c.722C>T	c.(721-723)TCC>TTC	p.S241F	TP53_uc002gig.1_Missense_Mutation_p.S241F|TP53_uc002gih.2_Missense_Mutation_p.S241F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.S109F|TP53_uc010cng.1_Missense_Mutation_p.S109F|TP53_uc002gii.1_Missense_Mutation_p.S109F|TP53_uc010cnh.1_Missense_Mutation_p.S241F|TP53_uc010cni.1_Missense_Mutation_p.S241F|TP53_uc002gij.2_Missense_Mutation_p.S241F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S148F|TP53_uc002gio.2_Missense_Mutation_p.S109F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	241	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(73)|p.S241C(24)|p.S241fs*6(8)|p.0?(7)|p.S241Y(7)|p.C242fs*5(6)|p.S241A(6)|p.S241del(5)|p.S241T(5)|p.N239_C242delNSSC(3)|p.S241S(3)|p.S241P(3)|p.S241fs*22(2)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.S241_G245delSCMGG(1)|p.C238fs*21(1)|p.S241fs*7(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241fs*23(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.013537	0	13	21									
MYH13	8735	broad.mit.edu	37	17	10216603	10216603	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:10216603A>T	uc002gmk.1	-	30	4143	c.4053T>A	c.(4051-4053)TAT>TAA	p.Y1351*		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1351	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GCTCCTCCTCATACTGTTCCC	0.602		NaN											0	0	0	0.010504	0	19	80									
AMAC1	146861	broad.mit.edu	37	17	33520951	33520951	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:33520951G>A	uc002hjd.2	-	1	462	c.376C>T	c.(376-378)CCC>TCC	p.P126S		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	126	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		TTGCCAGCGGGCACCACCTGA	0.607		NaN											0	0	0	0.01441	0	93	156									
MYO19	80179	broad.mit.edu	37	17	34864917	34864917	+	Silent	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:34864917C>A	uc010wcy.1	-	15	2207	c.1215G>T	c.(1213-1215)TCG>TCT	p.S405S	MYO19_uc002hmw.2_Silent_p.S405S|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	405	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGTGGTCCACGAGTCGGTGT	0.547		NaN											1	0	9.05144e-12	0.016723	1.00474e-11	12	17									
GPATCH8	23131	broad.mit.edu	37	17	42476849	42476849	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:42476849A>T	uc002igw.1	-	8	2660	c.2596T>A	c.(2596-2598)TCC>ACC	p.S866T	GPATCH8_uc002igv.1_Missense_Mutation_p.S788T|GPATCH8_uc010wiz.1_Missense_Mutation_p.S788T	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	866	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GAACGCCGGGAGGAACGATGC	0.537		NaN											0	0	0	0.017118	0	35	93									
ICT1	3396	broad.mit.edu	37	17	73016618	73016618	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:73016618C>G	uc002jmm.2	+	5	404	c.402C>G	c.(400-402)ATC>ATG	p.I134M		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	134					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					GAGAGTTGATCCTCACCTCTG	0.468		NaN											0	0	0	0.008291	0	10	61									
ITGB4	3691	broad.mit.edu	37	17	73738530	73738530	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:73738530C>G	uc002jpg.2	+	24	2929	c.2742C>G	c.(2740-2742)CTC>CTG	p.L914L	ITGB4_uc002jph.2_Silent_p.L914L|ITGB4_uc002jpi.3_Silent_p.L914L|ITGB4_uc010dgp.1_Missense_Mutation_p.Q927E|ITGB4_uc002jpj.2_Silent_p.L914L	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	914	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCACGACCTCAAGGTGGCCC	0.657		NaN											0	0	0	0.00308	0	8	14									
GAA	2548	broad.mit.edu	37	17	78082619	78082619	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78082619A>G	uc002jxo.2	+	9	1500	c.1318A>G	c.(1318-1320)ATG>GTG	p.M440V	GAA_uc002jxp.2_Missense_Mutation_p.M440V|GAA_uc002jxq.2_Missense_Mutation_p.M440V	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	440					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GCGCTACATGATGATCGTGGT	0.642		NaN											0	0	0	0.006214	0	7	11									
RNF213	57674	broad.mit.edu	37	17	78321834	78321834	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78321834C>T	uc002jyh.1	+	4	4141	c.3918C>T	c.(3916-3918)GTC>GTT	p.V1306V		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGCTGCAGGTCATAGAGAGGC	0.582		NaN											0	0	0	0.01892	0	21	66									
RPTOR	57521	broad.mit.edu	37	17	78519560	78519560	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78519560C>G	uc002jyt.1	+	1	936	c.131C>G	c.(130-132)TCC>TGC	p.S44C	RPTOR_uc002jys.2_Missense_Mutation_p.S44C|RPTOR_uc010wuf.1_Translation_Start_Site|RPTOR_uc010wug.1_Missense_Mutation_p.S44C|RPTOR_uc002jyr.1_Missense_Mutation_p.S44C	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	44					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						GGCTCCAAATCCTTAGCTCAG	0.478		NaN											0	0	0	0.010504	0	20	91									
ANKRD30B	374860	broad.mit.edu	37	18	14851705	14851705	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:14851705A>T	uc010dlo.2	+	36	3585	c.3405A>T	c.(3403-3405)AAA>AAT	p.K1135N	ANKRD30B_uc010xal.1_Missense_Mutation_p.K277N	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1220	Potential.									ovary(1)|skin(1)	2						TGAAACAGAAAACAGTAACAA	0.358		NaN											0	0	0	0.007413	0	19	22									
TAF4B	6875	broad.mit.edu	37	18	23854694	23854694	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:23854694T>A	uc002kvu.3	+	4	1154	c.665T>A	c.(664-666)CTG>CAG	p.L222Q	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.L222Q	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	222					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			GTAACTACCCTGAAGCCTTCA	0.428		NaN											0	0	0	0.004007	0	16	101									
SYT4	6860	broad.mit.edu	37	18	40851713	40851713	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:40851713G>C	uc002law.2	-	3	1303	c.934C>G	c.(934-936)CGA>GGA	p.R312G	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.R294G|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	312	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						GGCAGATGTCGAGCTTTTAAG	0.413		NaN											0	0	0	0.010729	0	12	65									
C3	718	broad.mit.edu	37	19	6679429	6679429	+	Missense_Mutation	SNP	C	C	T	rs142868256		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:6679429C>T	uc002mfm.2	-	37	4597	c.4535G>A	c.(4534-4536)CGC>CAC	p.R1512H	C3_uc002mfl.2_Missense_Mutation_p.R248H	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1512					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCAGCACAGCGGCACAGTTC	0.572		NaN											0	0	0	0.006999	0	38	77									
MUC16	94025	broad.mit.edu	37	19	9090928	9090928	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:9090928G>A	uc002mkp.2	-	1	1091	c.887C>T	c.(886-888)TCA>TTA	p.S296L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	296	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGGTCTCTGATATTTTATT	0.517		NaN											0	0	0	0.011902	0	43	46									
ILF3	3609	broad.mit.edu	37	19	10798322	10798322	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:10798322C>T	uc002mpn.2	+	18	2677	c.2360C>T	c.(2359-2361)TCG>TTG	p.S787L	ILF3_uc002mpo.2_Missense_Mutation_p.S791L|ILF3_uc002mpq.2_Nonsense_Mutation_p.R90*	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	787	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TACTCCTACTCGAACTCCTAC	0.597		NaN											0	0	0	0.008871	0	21	14									
DDA1	79016	broad.mit.edu	37	19	17426805	17426805	+	Splice_Site	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:17426805G>T	uc002ngd.2	+	4	325	c.198_splice	c.e4+1	p.K66_splice	DDA1_uc002nge.2_Splice_Site_p.E5_splice	NM_024050	NP_076955	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1											ovary(1)	1						GGACAAAAAGGTGAGGCCCAC	0.323		NaN											1	0	3.90053e-15	0.012213	4.34377e-15	34	175									
ZNF486	90649	broad.mit.edu	37	19	20308312	20308312	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:20308312C>A	uc002nou.2	+	4	850	c.793C>A	c.(793-795)CCC>ACC	p.P265T		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGGAGAGAAACCCTACATTTG	0.368		NaN											1	0	0.00198382	0.001984	0.00202515	7	31									
ZNF486	90649	broad.mit.edu	37	19	20308324	20308324	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:20308324G>A	uc002nou.2	+	4	862	c.805G>A	c.(805-807)GAA>AAA	p.E269K		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	269	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTACATTTGTGAAGAATGTGG	0.373		NaN											0	0	0	0.00308	0	8	35									
ZNF681	148213	broad.mit.edu	37	19	23927544	23927544	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:23927544T>C	uc002nrk.3	-	4	950	c.808A>G	c.(808-810)ACA>GCA	p.T270A	ZNF681_uc002nrl.3_Missense_Mutation_p.T201A|ZNF681_uc002nrj.3_Missense_Mutation_p.T201A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	270	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GTATGTGTTGTAATGTGTGAC	0.353		NaN											0	0	0	0.004007	0	17	47									
ARHGAP33	115703	broad.mit.edu	37	19	36278140	36278140	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:36278140G>A	uc002obs.1	+	21	2275	c.2190G>A	c.(2188-2190)CCG>CCA	p.P730P	ARHGAP33_uc002obt.1_Silent_p.P755P|ARHGAP33_uc010eel.2_Silent_p.P479P|ARHGAP33_uc002obv.1_Silent_p.P479P	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCCCACCCCCGCCCCCTAAGA	0.657		NaN											0	0	0	0.007835	0	41	17									
SPTBN4	57731	broad.mit.edu	37	19	41076526	41076526	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:41076526A>T	uc002ony.2	+	33	7297	c.7211A>T	c.(7210-7212)CAG>CTG	p.Q2404L	SPTBN4_uc002onz.2_Missense_Mutation_p.Q2404L|SPTBN4_uc010egx.2_Missense_Mutation_p.Q1147L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2404					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			gccccggcccagggcggctcc	0.343		NaN											0	0	0	0.009096	0	4	2									
PSG2	5670	broad.mit.edu	37	19	43579628	43579628	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:43579628G>C	uc002ovr.2	-	3	680	c.587C>G	c.(586-588)TCC>TGC	p.S196C	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.S196C|PSG2_uc010eiq.1_Missense_Mutation_p.S196C|PSG2_uc002ovs.3_Missense_Mutation_p.S196C|PSG2_uc002ovt.3_Missense_Mutation_p.S196C	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	196	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTTGGTTTCGGACAGCTGAAA	0.493		NaN											0	0	0	0.01441	0	125	798									
IRGQ	126298	broad.mit.edu	37	19	44097062	44097062	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44097062G>A	uc002oww.2	-	2	1106	c.988C>T	c.(988-990)CGC>TGC	p.R330C	IRGQ_uc010eiv.2_Missense_Mutation_p.R330C	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	330							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				CCGTCTGTGCGCACGCAGACA	0.632		NaN											0	0	0	0.013537	0	13	264									
ZNF229	7772	broad.mit.edu	37	19	44933335	44933335	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44933335C>T	uc002oze.1	-	6	2055	c.1621G>A	c.(1621-1623)GGA>AGA	p.G541R	ZNF229_uc010ejk.1_Missense_Mutation_p.G195R|ZNF229_uc010ejl.1_Missense_Mutation_p.G535R	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				GGTTTCTCTCCTGTGTGCAGT	0.512		NaN											0	0	0	0.01441	0	145	87									
CRX	1406	broad.mit.edu	37	19	48342712	48342712	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:48342712G>A	uc002phq.3	+	4	592	c.388G>A	c.(388-390)GAT>AAT	p.D130N		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	130					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		ACCCTCCACAGATGTGTGTCC	0.567		NaN											0	0	0	0.015359	0	37	81									
FUT2	2524	broad.mit.edu	37	19	49206253	49206253	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:49206253C>A	uc002pke.3	+	2	151	c.40C>A	c.(40-42)CAC>AAC	p.H14N	FUT2_uc010emc.2_Missense_Mutation_p.H14N	NM_001097638	NP_001091107	Q10981	FUT2_HUMAN	fucosyltransferase 2	14	Cytoplasmic (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			central_nervous_system(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		TCCCATGGCCCACTTCATCCT	0.547		NaN											1	0	1.1362e-29	0.01441	1.29045e-29	61	184									
PPFIA3	8541	broad.mit.edu	37	19	49643235	49643235	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:49643235C>T	uc002pmr.2	+	18	2590	c.2258C>T	c.(2257-2259)TCT>TTT	p.S753F	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.S621F|PPFIA3_uc002pmt.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	753						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACCCCAGATTCTCTGCACAAA	0.562		NaN											0	0	0	0.01441	0	68	110									
HAS1	3036	broad.mit.edu	37	19	52220265	52220265	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:52220265C>T	uc002pxo.1	-	3	919	c.884G>A	c.(883-885)TGT>TAT	p.C295Y	HAS1_uc010epc.1_5'UTR|HAS1_uc010epd.1_Missense_Mutation_p.C260Y|HAS1_uc002pxn.1_Missense_Mutation_p.C302Y|HAS1_uc002pxp.1_Missense_Mutation_p.C294Y	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	295	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GTAGCTCTGACAAGCCCGCTC	0.577		NaN											0	0	0	0.01441	0	53	159									
ZNF805	390980	broad.mit.edu	37	19	57764890	57764890	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:57764890G>A	uc010ygt.1	+	4	910	c.703G>A	c.(703-705)GAG>AAG	p.E235K	ZNF805_uc010ygu.1_Missense_Mutation_p.E102K	NM_001023563	NP_001018857	Q5CZA5	ZN805_HUMAN	zinc finger protein 805 isoform 1	235	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAATGCACAGAGTGTGGAAA	0.458		NaN											0	0	0	0.004672	0	3	18									
ZNF548	147694	broad.mit.edu	37	19	57908460	57908460	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:57908460G>T	uc002qom.2	+	2	310	c.60G>T	c.(58-60)GAG>GAT	p.E20D	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.E23D	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTCCCAGGAGGAGTGGGGGC	0.488		NaN											1	0	1.15966e-41	0.01441	1.32147e-41	96	171									
ZNF606	80095	broad.mit.edu	37	19	58491154	58491154	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:58491154G>A	uc002qqw.2	-	7	1512	c.894C>T	c.(892-894)TTC>TTT	p.F298F	ZNF606_uc010yhp.1_Silent_p.F208F	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	298	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TTATATGATTGAAAGATTTAA	0.318		NaN											0	0	0	0.008871	0	21	49									
A1BG	1	broad.mit.edu	37	19	58862857	58862857	+	Silent	SNP	G	G	A	rs140428520		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:58862857G>A	uc002qsd.3	-	5	872	c.810C>T	c.(808-810)GCC>GCT	p.A270A	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	270	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CATCCCCCAGGGCCACCGCGT	0.632		NaN											0	0	0	0.00308	0	8	46									
PPM1G	5496	broad.mit.edu	37	2	27608625	27608625	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:27608625T>A	uc002rkl.2	-	5	505	c.398A>T	c.(397-399)GAT>GTT	p.D133V	PPM1G_uc002rkm.2_5'UTR	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	133					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATCATCTTCATCAGCTACTTT	0.393		NaN											0	0	0	0.019004	0	32	66									
SUPT7L	9913	broad.mit.edu	37	2	27876591	27876591	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:27876591G>C	uc002rlh.1	-	6	1349	c.1006C>G	c.(1006-1008)CTT>GTT	p.L336V	SUPT7L_uc002rli.1_Missense_Mutation_p.L336V|SUPT7L_uc010ymf.1_Missense_Mutation_p.L201V|SUPT7L_uc002rlj.1_Missense_Mutation_p.L334V|SUPT7L_uc010ezh.1_Missense_Mutation_p.L334V	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	336					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					AGATTCCAAAGAGGAGAAGCA	0.448		NaN											0	0	0	0.006999	0	39	93									
XDH	7498	broad.mit.edu	37	2	31591514	31591514	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:31591514C>T	uc002rnv.1	-	19	2072	c.1993G>A	c.(1993-1995)GGG>AGG	p.G665R		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	665					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ATGATATGCCCAACACAAGTA	0.443		NaN											0	0	0	0.00632	0	26	66									
MTIF2	4528	broad.mit.edu	37	2	55479634	55479634	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:55479634G>C	uc002ryn.2	-	9	1557	c.820C>G	c.(820-822)CAG>GAG	p.Q274E	MTIF2_uc010yox.1_Intron|MTIF2_uc002ryo.2_Missense_Mutation_p.Q274E	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	274	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						TTGGCATGCTGAATAGATTCT	0.393		NaN											0	0	0	0.012213	0	28	74									
PPP3R1	5534	broad.mit.edu	37	2	68408096	68408096	+	Nonstop_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:68408096C>G	uc002sei.1	-	6	904	c.512G>C	c.(511-513)TGA>TCA	p.*171S		NM_000945	NP_000936	P63098	CANB1_HUMAN	protein phosphatase 3, regulatory subunit B,	171					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding				0					Pimecrolimus(DB00337)	TGATAAGAGTCACACATCTAC	0.433		NaN											0	0	0	0.001168	0	5	23									
MXD1	4084	broad.mit.edu	37	2	70164512	70164512	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:70164512C>G	uc002sfy.2	+	5	724	c.464C>G	c.(463-465)TCC>TGC	p.S155C	MXD1_uc010yqp.1_Missense_Mutation_p.S155C|MXD1_uc010yqq.1_Missense_Mutation_p.S92C|MXD1_uc010yqr.1_RNA|MXD1_uc010yqs.1_Missense_Mutation_p.S145C	NM_002357	NP_002348	Q05195	MAD1_HUMAN	MAX dimerization protein 1	155					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						TCGGAGCGCTCCGACTCCGAC	0.627		NaN											0	0	0	0.006122	0	19	42									
ZAP70	7535	broad.mit.edu	37	2	98340656	98340656	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:98340656G>C	uc002syd.1	+	3	364	c.157G>C	c.(157-159)GAT>CAT	p.D53H	ZAP70_uc010yvf.1_Missense_Mutation_p.D53H|ZAP70_uc002sye.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	53	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GCTCGTGCACGATGTGCGCTT	0.672		NaN											0	0	0	0.013537	0	13	11									
MGAT4A	11320	broad.mit.edu	37	2	99294780	99294780	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294780C>G	uc002sze.2	-	3	563	c.249G>C	c.(247-249)TTG>TTC	p.L83F	MGAT4A_uc010fil.2_5'UTR	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	83	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						AAAACTTATTCAACGCATCCT	0.249		NaN											0	0	0	0.004007	0	17	108									
MGAT4A	11320	broad.mit.edu	37	2	99294910	99294911	+	Missense_Mutation	DNP	TC	TC	AT			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294910_99294911TC>AT	uc002sze.2	-	3	432_433	c.118_119GA>AT	c.(118-120)GAA>ATA	p.E40I	MGAT4A_uc010fil.2_5'UTR	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	40	Lumenal (Potential).|Potential.				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						AGCAAGGAATTCTCGTTGATAA	0.337		NaN											0	0	0	0.004672	0	18	85									
GLI2	2736	broad.mit.edu	37	2	121744054	121744054	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:121744054G>A	uc010flp.2	+	12	2187	c.2157G>A	c.(2155-2157)CTG>CTA	p.L719L	GLI2_uc002tmq.1_Silent_p.L391L|GLI2_uc002tmr.1_Silent_p.L374L|GLI2_uc002tmt.3_Silent_p.L391L|GLI2_uc002tmu.3_Silent_p.L374L|GLI2_uc002tmw.1_Silent_p.L702L	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	719				QL -> HV (in Ref. 4; BAA03568/BAA03569).	axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCCTCCAGCTGCGCAAACACA	0.657		NaN											0	0	0	0.001168	0	6	21									
ERCC3	2071	broad.mit.edu	37	2	128036775	128036775	+	Silent	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:128036775T>C	uc002toh.1	-	10	1799	c.1704A>G	c.(1702-1704)CTA>CTG	p.L568L	ERCC3_uc002toe.1_Silent_p.L323L|ERCC3_uc002tof.1_Silent_p.L504L|ERCC3_uc002tog.1_Silent_p.L504L	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	568	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CATATTCCTTTAGGGCAAACA	0.428		NaN	Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.00499	0	17	22									
GPR17	2840	broad.mit.edu	37	2	128408390	128408390	+	Silent	SNP	G	G	A	rs145234598		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:128408390G>A	uc010yzn.1	+	4	776	c.165G>A	c.(163-165)ACG>ACA	p.T55T	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.T55T|GPR17_uc010yzo.1_Silent_p.T27T|GPR17_uc002tpd.2_Silent_p.T27T	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	55	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		gccaggagacgccactggaga	0.1		NaN									OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.020292	0	14	56									
TTN	7273	broad.mit.edu	37	2	179448568	179448568	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:179448568G>C	uc010zfg.1	-	261	57861	c.57637C>G	c.(57637-57639)CCA>GCA	p.P19213A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P12908A|TTN_uc010zfi.1_Missense_Mutation_p.P12841A|TTN_uc010zfj.1_Missense_Mutation_p.P12716A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20140							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATGCTTTGGACGAGCCCAG	0.428		NaN											0	0	0	0.001168	0	6	10									
FN1	2335	broad.mit.edu	37	2	216237060	216237060	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:216237060G>C	uc002vfa.2	-	40	6552	c.6286C>G	c.(6286-6288)CTT>GTT	p.L2096V	FN1_uc002vfb.2_Missense_Mutation_p.L1915V|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Missense_Mutation_p.L2005V|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Missense_Mutation_p.L1915V|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Missense_Mutation_p.L2096V|FN1_uc002vfj.2_Intron|FN1_uc002vez.2_Missense_Mutation_p.L290V|FN1_uc010zjp.1_Missense_Mutation_p.L633V|FN1_uc002vfk.1_Intron|FN1_uc010fva.1_Intron|FN1_uc010fvb.1_Intron|FN1_uc010fvc.1_Intron|FN1_uc010fvd.1_Missense_Mutation_p.L187V	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2005	Connecting strand 3 (CS-3) (V region).				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTCCATGAAGATTGGGGTGT	0.502		NaN											0	0	0	0.015359	0	34	29									
SPEG	10290	broad.mit.edu	37	2	220326632	220326632	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:220326632C>G	uc010fwg.2	+	7	2469	c.2469C>G	c.(2467-2469)CCC>CCG	p.P823P	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Silent_p.P31P|SPEG_uc002vln.1_Silent_p.P31P|SPEG_uc002vlp.1_Silent_p.P31P|SPEG_uc002vlq.2_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	823					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCAGCAGCCCCATCACCTCCG	0.627		NaN											0	0	0	0.019004	0	36	46									
ITM2C	81618	broad.mit.edu	37	2	231738161	231738161	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:231738161G>C	uc002vqz.2	+	2	270	c.150G>C	c.(148-150)AAG>AAC	p.K50N	ITM2C_uc002vra.2_Intron|ITM2C_uc002vrb.2_Missense_Mutation_p.K50N|ITM2C_uc002vrc.2_5'Flank|ITM2C_uc002vrd.2_5'Flank	NM_030926	NP_112188	Q9NQX7	ITM2C_HUMAN	integral membrane protein 2C isoform 1	50					negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding				0		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		ATCGATCCAAGAGGGGGGGCT	0.612		NaN											0	0	0	0.001168	0	6	27									
COL6A3	1293	broad.mit.edu	37	2	238303321	238303321	+	Silent	SNP	A	A	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:238303321A>C	uc002vwl.2	-	3	903	c.618T>G	c.(616-618)CTT>CTG	p.L206L	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Silent_p.L206L	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	206	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTATGTCATGAAGTGAGGTAA	0.433		NaN											0	0	0	0.008291	0	11	37									
MAP1LC3A	84557	broad.mit.edu	37	20	33147573	33147573	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:33147573C>T	uc002xaq.1	+	4	391	c.237C>T	c.(235-237)TTC>TTT	p.F79F	MAP1LC3A_uc002xap.1_Silent_p.F83F	NM_032514	NP_115903	Q9H492	MLP3A_HUMAN	microtubule-associated protein 1 light chain 3	79					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding				0						CGCAGGCCTTCTTCCTGCTGG	0.632		NaN											0	0	0	0.021523	0	26	69									
GDF5	8200	broad.mit.edu	37	20	34022096	34022096	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:34022096G>A	uc002xck.1	-	2	1436	c.1117C>T	c.(1117-1119)CTG>TTG	p.L373L	GDF5_uc010gfc.1_Silent_p.L373L|uc002xcj.2_Silent_p.Q169Q|GDF5_uc010zvc.1_Silent_p.L373L	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	373			L -> R (in SYM1; the mature GDF5 protein is detected as the wild-type in the supernatant derived from the mutant transfected cells).		cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TGGCTGAACAGGTACTCATAC	0.597		NaN											0	0	0	0.01441	0	57	114									
SAMHD1	25939	broad.mit.edu	37	20	35547851	35547851	+	Silent	SNP	T	T	C	rs140804613	byFrequency	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:35547851T>C	uc002xgh.1	-	7	898	c.768A>G	c.(766-768)CAA>CAG	p.Q256Q		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	256	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TGAGACCATATTGTTCCATGA	0.358		NaN											0	0	0	0.013537	0	13	41									
NFATC2	4773	broad.mit.edu	37	20	50139915	50139915	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:50139915C>T	uc002xwd.2	-	2	1085	c.865G>A	c.(865-867)GGC>AGC	p.G289S	NFATC2_uc002xwc.2_Missense_Mutation_p.G289S|NFATC2_uc010zyv.1_Missense_Mutation_p.G70S|NFATC2_uc010zyw.1_Missense_Mutation_p.G70S|NFATC2_uc010zyx.1_Missense_Mutation_p.G269S|NFATC2_uc010zyy.1_Missense_Mutation_p.G70S|NFATC2_uc010zyz.1_Missense_Mutation_p.G70S|NFATC2_uc002xwe.2_Missense_Mutation_p.G269S	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	289					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GCCGGGGAGCCGTGGTCCTGG	0.711		NaN											0	0	0	0.014758	0	4	14									
GABPA	2551	broad.mit.edu	37	21	27130395	27130395	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:27130395A>G	uc002ylx.3	+	6	1155	c.628A>G	c.(628-630)ATA>GTA	p.I210V	GABPA_uc002yly.3_Missense_Mutation_p.I210V	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	210	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						CATGACCGATATAGACCTCAC	0.438		NaN											0	0	0	0.013537	0	11	68									
CLDN8	9073	broad.mit.edu	37	21	31587705	31587705	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:31587705G>T	uc002ynu.1	-	1	614	c.539C>A	c.(538-540)GCT>GAT	p.A180D		NM_199328	NP_955360	P56748	CLD8_HUMAN	claudin 8	180	Helical; (Potential).				calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GCAGAACAGAGCTCCTCCAAC	0.453		NaN											1	0	0.00909568	0.009096	0.00917594	4	65									
RIPK4	54101	broad.mit.edu	37	21	43161747	43161747	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:43161747C>T	uc002yzn.1	-	8	1654	c.1606G>A	c.(1606-1608)GAG>AAG	p.E536K		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	536						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GTCCGGCCCTCAAAGTCCACC	0.647		NaN											0	0	0	0.00499	0	17	47									
UBASH3A	53347	broad.mit.edu	37	21	43836631	43836631	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:43836631G>C	uc002zbe.2	+	6	784	c.748G>C	c.(748-750)GAG>CAG	p.E250Q	UBASH3A_uc002zbf.2_Missense_Mutation_p.E212Q|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.E212Q	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	250						cytosol|nucleus				ovary(3)	3						GAGGACGCTGGAGCAGCTGGC	0.597		NaN											0	0	0	0.003163	0	16	21									
PFKL	5211	broad.mit.edu	37	21	45746744	45746744	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:45746744G>A	uc002zel.2	+	22	2401	c.2342G>A	c.(2341-2343)TGA>TAA	p.*781*	PFKL_uc002zek.2_Silent_p.*828*|PFKL_uc002zem.2_Silent_p.*368*|PFKL_uc002zen.2_Silent_p.*368*	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	781					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		AAGGGCTTCTGAGGCCAGCCA	0.667		NaN											0	0	0	0.014758	0	5	4									
TRPM2	7226	broad.mit.edu	37	21	45811248	45811248	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:45811248G>A	uc002zet.1	+	12	1747	c.1534G>A	c.(1534-1536)GAG>AAG	p.E512K	TRPM2_uc002zeu.1_Missense_Mutation_p.E512K|TRPM2_uc002zew.1_Missense_Mutation_p.E512K|TRPM2_uc010gpt.1_Missense_Mutation_p.E512K|TRPM2_uc002zex.1_Missense_Mutation_p.E298K|TRPM2_uc002zey.1_Missense_Mutation_p.E25K	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	512	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAGCTGAAGGAGTTTGTCAC	0.567		NaN											0	0	0	0.013726	0	33	60									
POTEH	23784	broad.mit.edu	37	22	16287675	16287675	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:16287675A>G	uc010gqp.2	-	1	263	c.211T>C	c.(211-213)TGG>CGG	p.W71R	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	71										skin(1)	1						CCCCTGCACCAGGGGAAGCAG	0.582		NaN											0	0	0	0.01441	0	53	140									
MRPL40	64976	broad.mit.edu	37	22	19423455	19423455	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:19423455G>C	uc002zpg.2	+	4	633	c.591G>C	c.(589-591)AAG>AAC	p.K197N	HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zph.2_Missense_Mutation_p.K153N	NM_003776	NP_003767	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40 precursor	197					anatomical structure morphogenesis	mitochondrial ribosome|nucleus					0	Colorectal(54;0.0993)					ACATCACCAAGGTGTACACAC	0.502		NaN											0	0	0	0.010729	0	11	50									
TCN2	6948	broad.mit.edu	37	22	31010392	31010392	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:31010392C>G	uc003aip.1	+	4	642	c.484C>G	c.(484-486)CTG>GTG	p.L162V	TCN2_uc003aiq.1_Missense_Mutation_p.L158V|TCN2_uc003air.1_Missense_Mutation_p.L135V	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	162					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCTGGGCATTCTGGCCCTGTG	0.577		NaN											0	0	0	0.007291	0	29	25									
CACNG2	10369	broad.mit.edu	37	22	37098579	37098579	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:37098579C>T	uc003aps.1	-	1	325	c.43G>A	c.(43-45)GTT>ATT	p.V15I	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	15	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						AAAGCACCAACGGTGGTTAAA	0.478		NaN											0	0	0	0.01441	0	57	60									
MCHR1	2847	broad.mit.edu	37	22	41077323	41077323	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:41077323C>T	uc003ayz.2	+	2	928	c.660C>T	c.(658-660)TCC>TCT	p.S220S	MCHR1_uc003aza.2_Silent_p.S109S	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	220	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						CCATCTCTTCCACGAAGTTCC	0.587		NaN											0	0	0	0.004656	0	26	51									
EFCAB6	64800	broad.mit.edu	37	22	44083357	44083357	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:44083357C>T	uc003bdy.1	-	11	1351	c.1136G>A	c.(1135-1137)AGA>AAA	p.R379K	EFCAB6_uc003bdz.1_Missense_Mutation_p.R227K|EFCAB6_uc010gzi.1_Missense_Mutation_p.R227K|EFCAB6_uc010gzk.1_Intron|EFCAB6_uc011aqa.1_Intron|EFCAB6_uc003bea.1_Missense_Mutation_p.R376K	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				ATACCTATTTCTTTTTGTCAG	0.308		NaN											0	0	0	0.016723	0	13	24									
CLASP2	23122	broad.mit.edu	37	3	33626305	33626305	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:33626305T>C	uc003cfu.2	-	22	2530	c.2176A>G	c.(2176-2178)AGA>GGA	p.R726G	CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.R319G	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	727										ovary(3)|central_nervous_system(1)	4						ATCTTGCTTCTTTTTTGTGCT	0.473		NaN											0	0	0	0.008361	0	31	38									
SCN10A	6336	broad.mit.edu	37	3	38743492	38743492	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743492C>G	uc003ciq.2	-	26	4495	c.4495G>C	c.(4495-4497)GAC>CAC	p.D1499H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1499	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCACTTTGGTCATCAGTCTCC	0.458		NaN											0	0	0	0.009535	0	31	89									
SCN10A	6336	broad.mit.edu	37	3	38743576	38743576	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743576C>G	uc003ciq.2	-	26	4411	c.4411G>C	c.(4411-4413)GAC>CAC	p.D1471H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1471	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTCACGATGTCAAAGACAAAA	0.458		NaN											0	0	0	0.007413	0	17	80									
SCN10A	6336	broad.mit.edu	37	3	38743601	38743601	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743601C>G	uc003ciq.2	-	26	4387	c.4387_splice	c.e26-1	p.N1463_splice		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha						sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGAACTTGTTCTGAGAAAACA	0.468		NaN											0	0	0	0.00499	0	16	66									
NKTR	4820	broad.mit.edu	37	3	42678832	42678832	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:42678832C>G	uc003clo.2	+	13	1783	c.1636C>G	c.(1636-1638)CGA>GGA	p.R546G	NKTR_uc003clm.1_Missense_Mutation_p.R293G|NKTR_uc003clp.2_Missense_Mutation_p.R293G|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R436G|NKTR_uc003clr.1_Missense_Mutation_p.R293G|NKTR_uc003cls.2_Missense_Mutation_p.R246G	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	546	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		ATCACATTCTCGAAGTAGATC	0.418		NaN											0	0	0	0.005524	0	39	117									
IQCF2	389123	broad.mit.edu	37	3	51895685	51895685	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:51895685G>C	uc003dbt.1	+	1	41	c.3G>C	c.(1-3)ATG>ATC	p.M1I	IQCF1_uc003dbq.3_Intron|IQCF2_uc003dbu.1_RNA	NM_203424	NP_982248	Q8IXL9	IQCF2_HUMAN	IQ motif containing F2	1											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GACAGGCCATGAGGGTTCGAT	0.483		NaN											0	0	0	0.010504	0	18	26									
FLNB	2317	broad.mit.edu	37	3	58088057	58088057	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:58088057G>A	uc003djj.2	+	9	1638	c.1473G>A	c.(1471-1473)ATG>ATA	p.M491I	FLNB_uc010hne.2_Missense_Mutation_p.M491I|FLNB_uc003djk.2_Missense_Mutation_p.M491I|FLNB_uc010hnf.2_Missense_Mutation_p.M491I|FLNB_uc003djl.2_Missense_Mutation_p.M322I|FLNB_uc003djm.2_Missense_Mutation_p.M322I	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	491	Filamin 3.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GTGTAACCATGAAGGGTCCTA	0.522		NaN											0	0	0	0.013726	0	35	47									
IMPG2	50939	broad.mit.edu	37	3	100992518	100992518	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:100992518G>A	uc003duq.1	-	7	938	c.735C>T	c.(733-735)TTC>TTT	p.F245F	IMPG2_uc011bhe.1_Silent_p.F108F	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	245	Extracellular (Potential).|SEA 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGTGGATACTGAATTCTGCAA	0.403		NaN											0	0	0	0.008291	0	11	24									
COPG	22820	broad.mit.edu	37	3	128979195	128979195	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:128979195C>T	uc003els.2	+	11	991	c.891C>T	c.(889-891)AGC>AGT	p.S297S	COPG_uc010htb.2_Silent_p.S203S	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	297	HEAT 2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						TTTTCTGCAGCTCACCCAAGG	0.562		NaN											0	0	0	0.021523	0	21	101									
SLCO2A1	6578	broad.mit.edu	37	3	133698434	133698434	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:133698434T>A	uc003eqa.3	-	2	399	c.125A>T	c.(124-126)CAG>CTG	p.Q42L	SLCO2A1_uc003eqb.3_Missense_Mutation_p.Q42L|SLCO2A1_uc011blv.1_Missense_Mutation_p.Q42L|SLCO2A1_uc010htw.1_5'UTR	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	42	Helical; Name=1; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						TTGGCAGAGCTGCAGGAGGCC	0.587		NaN											0	0	0	0.00632	0	27	74									
STAG1	10274	broad.mit.edu	37	3	136192446	136192446	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:136192446G>C	uc003era.1	-	11	1352	c.1060C>G	c.(1060-1062)CTG>GTG	p.L354V	STAG1_uc003erb.1_Missense_Mutation_p.L354V|STAG1_uc003erc.1_Missense_Mutation_p.L128V|STAG1_uc010hua.1_Missense_Mutation_p.L217V	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	354	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						AGACTCTGCAGAGCTTTCAAA	0.338		NaN											0	0	0	0.014323	0	22	49									
PLOD2	5352	broad.mit.edu	37	3	145790403	145790403	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:145790403T>A	uc003evs.1	-	16	2236	c.1730A>T	c.(1729-1731)GAT>GTT	p.D577V	PLOD2_uc003evq.1_Missense_Mutation_p.D258V|PLOD2_uc011bnm.1_Missense_Mutation_p.D543V|PLOD2_uc003evr.1_Missense_Mutation_p.D598V	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	577					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TACCAATTCATCACAGGCTTT	0.343		NaN											0	0	0	0.016723	0	12	39									
ZIC1	7545	broad.mit.edu	37	3	147128322	147128322	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:147128322C>G	uc003ewe.2	+	1	1142	c.423C>G	c.(421-423)CTC>CTG	p.L141L		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	141					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CGGGCCACCTCCTCTTCCCCG	0.726		NaN											0	0	0	0.004672	0	3	18									
TNIK	23043	broad.mit.edu	37	3	170858210	170858210	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:170858210C>T	uc003fhh.2	-	13	1655	c.1310G>A	c.(1309-1311)AGG>AAG	p.R437K	TNIK_uc003fhi.2_Missense_Mutation_p.R437K|TNIK_uc003fhj.2_Missense_Mutation_p.R437K|TNIK_uc003fhk.2_Missense_Mutation_p.R437K|TNIK_uc003fhl.2_Missense_Mutation_p.R437K|TNIK_uc003fhm.2_Missense_Mutation_p.R437K|TNIK_uc003fhn.2_Missense_Mutation_p.R437K|TNIK_uc003fho.2_Missense_Mutation_p.R437K	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	437	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CGCACGCCTCCTCTCCTCCTC	0.662		NaN											0	0	0	0.01441	0	52	108									
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	T	rs121913279		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:178952085A>T	uc003fjk.2	+	21	3297	c.3140A>T	c.(3139-3141)CAT>CTT	p.H1047L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.005524	0	41	55									
HGFAC	3083	broad.mit.edu	37	4	3446124	3446124	+	Missense_Mutation	SNP	G	G	C	rs138611679		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:3446124G>C	uc003ghc.2	+	6	688	c.685G>C	c.(685-687)GAG>CAG	p.E229Q	HGFAC_uc010icw.2_Missense_Mutation_p.E229Q	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	229	Fibronectin type-I.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGAACAGTGCGAGTGCTTCGG	0.677		NaN											0	0	0	0.004672	0	3	6									
RELL1	768211	broad.mit.edu	37	4	37687844	37687844	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:37687844C>T	uc003gsz.2	-	1	156	c.66G>A	c.(64-66)GTG>GTA	p.V22V	RELL1_uc010ifc.2_Silent_p.V22V	NM_001085399	NP_001078868	Q8IUW5	RELL1_HUMAN	receptor expressed in lymphoid tissues like 1	22						cytoplasm|integral to membrane|microtubule cytoskeleton|plasma membrane					0						GCGGCGAACTCACGGCGCCTC	0.761		NaN											0	0	0	0.014758	0	3	8									
AASDH	132949	broad.mit.edu	37	4	57221444	57221444	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:57221444T>C	uc003hbn.2	-	6	1160	c.1007A>G	c.(1006-1008)AAT>AGT	p.N336S	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.N183S|AASDH_uc003hbo.2_Missense_Mutation_p.N236S|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Missense_Mutation_p.N336S|AASDH_uc003hbp.2_Missense_Mutation_p.N336S	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	336					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TTGTGTTTTATTGCCTTCTCC	0.403		NaN											0	0	0	0.010818	0	31	139									
ENAM	10117	broad.mit.edu	37	4	71500192	71500193	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500192_71500193CC>AA	uc011caw.1	+	6	659_660	c.378_379CC>AA	c.(376-381)AACCAG>AAAAAG	p.126_127NQ>KK		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	126_127					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AGAAACCCAACCAGACTCAGTC	0.52		NaN											0	0	0	0.004672	0	11	24									
ENAM	10117	broad.mit.edu	37	4	71500195	71500195	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500195G>A	uc011caw.1	+	6	662	c.381G>A	c.(379-381)CAG>CAA	p.Q127Q		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	127					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AACCCAACCAGACTCAGTCAA	0.522		NaN											0	0	0	0.012319	0	11	23									
GK2	2712	broad.mit.edu	37	4	80328580	80328580	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:80328580C>T	uc003hlu.2	-	1	793	c.775G>A	c.(775-777)GAC>AAC	p.D259N		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	259		Substrate (By similarity).			glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						GCACATTGGTCCCCCAAACAC	0.458		NaN											0	0	0	0.00632	0	29	68									
GALNTL6	442117	broad.mit.edu	37	4	173150860	173150860	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:173150860G>C	uc003isv.2	+	3	928	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	64	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						CAGATGGTTTGAGAAGAAAGG	0.443		NaN											0	0	0	0.00308	0	7	23									
BRD9	65980	broad.mit.edu	37	5	887497	887497	+	Silent	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:887497T>A	uc003jbq.2	-	6	863	c.696A>T	c.(694-696)GCA>GCT	p.A232A	BRD9_uc003jbl.2_Silent_p.A116A|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Silent_p.A179A|BRD9_uc003jbo.2_Silent_p.A116A|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	232							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			TCTTAAAGCCTGCGTGAAGGA	0.498		NaN											0	0	0	0.005443	0	23	130									
LPCAT1	79888	broad.mit.edu	37	5	1479749	1479749	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:1479749T>A	uc003jcm.2	-	8	920	c.803A>T	c.(802-804)CAA>CTA	p.Q268L		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	268	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GATTTCCACTTGGTTGTGAAA	0.448		NaN									OREG0016481	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	11	26									
IRX4	50805	broad.mit.edu	37	5	1879903	1879903	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:1879903G>A	uc003jcz.2	-	4	570	c.451C>T	c.(451-453)CGC>TGC	p.R151C	IRX4_uc011cmf.1_Missense_Mutation_p.R12C	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	151	Homeobox; TALE-type.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		GTGGTCTCGCGCGTGGCGTTC	0.637		NaN											0	0	0	0.010504	0	21	38									
ROPN1L	83853	broad.mit.edu	37	5	10461368	10461368	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:10461368C>T	uc003jex.3	+	4	761	c.490C>T	c.(490-492)CCC>TCC	p.P164S		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	164					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CGCTCGCATCCCCTTCAAGAC	0.567		NaN											0	0	0	0.00499	0	18	105									
LMBRD2	92255	broad.mit.edu	37	5	36143342	36143342	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:36143342C>G	uc003jkb.1	-	2	525	c.110G>C	c.(109-111)GGA>GCA	p.G37A		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	37	Helical; (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGCAGTGTTCCAATAATCAC	0.363		NaN											0	0	0	0.004007	0	16	44									
C5orf42	65250	broad.mit.edu	37	5	37195984	37195984	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:37195984C>T	uc011cpa.1	-	21	4018	c.3787G>A	c.(3787-3789)GAT>AAT	p.D1263N	C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.D338N|C5orf42_uc011cpb.1_Missense_Mutation_p.D144N	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1263										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GAAACTTCATCAAGCTTGTGG	0.378		NaN											0	0	0	0.006214	0	10	70									
EMB	133418	broad.mit.edu	37	5	49695706	49695706	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:49695706C>T	uc003jom.2	-	8	1202	c.953G>A	c.(952-954)AGG>AAG	p.R318K	EMB_uc010ivq.2_Missense_Mutation_p.R112K|EMB_uc003jol.2_Missense_Mutation_p.R249K|EMB_uc011cpy.1_Missense_Mutation_p.R268K|EMB_uc010ivr.2_Missense_Mutation_p.R264K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	318	Cytoplasmic (Potential).					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTTTCTATGCCTGGGGACATT	0.269		NaN											0	0	0	0.001984	0	7	44									
RNF180	285671	broad.mit.edu	37	5	63509826	63509826	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:63509826C>A	uc003jti.2	+	4	783	c.673C>A	c.(673-675)CAT>AAT	p.H225N	RNF180_uc003jth.3_Missense_Mutation_p.H225N|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	225	Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		AAGAGCTTTTCATAGAAAATC	0.388		NaN											1	0	1.08312e-15	0.009535	1.21013e-15	31	46									
MAN2A1	4124	broad.mit.edu	37	5	109152978	109152978	+	Missense_Mutation	SNP	C	C	T	rs142458296		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:109152978C>T	uc003kou.1	+	13	2911	c.1948C>T	c.(1948-1950)CTT>TTT	p.L650F		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	650	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TTGCAGGTACCTTGTGGTCTA	0.318		NaN											0	0	0	0.016723	0	11	81									
PCDHA6	56142	broad.mit.edu	37	5	140208233	140208233	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140208233G>A	uc003lho.2	+	1	584	c.557G>A	c.(556-558)AGT>AAT	p.S186N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.S186N|PCDHA6_uc011dab.1_Missense_Mutation_p.S186N	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	186	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAATAAACAGTGATGACAAT	0.443		NaN											0	0	0	0.012213	0	34	56									
PCDHA12	56137	broad.mit.edu	37	5	140256681	140256681	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140256681G>T	uc003lic.2	+	1	1751	c.1624G>T	c.(1624-1626)GTG>TTG	p.V542L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.V542L	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	542	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACGCCGGCGTGCCGCCTCT	0.701		NaN											1	0	2.24893e-16	0.009718	2.52086e-16	43	79									
PCDHA13	56136	broad.mit.edu	37	5	140263756	140263756	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140263756C>T	uc003lif.2	+	1	1903	c.1903C>T	c.(1903-1905)CGC>TGC	p.R635C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.R635C|PCDHA13_uc003lid.2_Missense_Mutation_p.R635C	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCACGACGCGCCCTCTGGA	0.677		NaN											0	0	0	0.00623	0	42	50									
PCDHB12	56124	broad.mit.edu	37	5	140589944	140589944	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140589944T>A	uc003liz.2	+	1	1654	c.1465T>A	c.(1465-1467)TCG>ACG	p.S489T	PCDHB12_uc011dak.1_Missense_Mutation_p.S152T	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	489	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCAACTACTCGCTGCTGCC	0.657		NaN											0	0	0	0.00499	0	16	102									
KIF4B	285643	broad.mit.edu	37	5	154396083	154396083	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:154396083G>T	uc010jih.1	+	1	2824	c.2664G>T	c.(2662-2664)CTG>CTT	p.L888L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	888	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAAACAGCCTGAGACAGAGCA	0.438		NaN											1	0	4.35082e-09	0.010504	4.69286e-09	20	34									
ODZ2	57451	broad.mit.edu	37	5	167674760	167674760	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:167674760G>C	uc010jjd.2	+	27	6789	c.6789G>C	c.(6787-6789)CAG>CAC	p.Q2263H	ODZ2_uc003lzr.3_Missense_Mutation_p.Q2033H|ODZ2_uc003lzt.3_Missense_Mutation_p.Q1636H|ODZ2_uc010jje.2_Missense_Mutation_p.Q1527H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ATCTGTGCCAGAGAGGGTCTG	0.542		NaN											0	0	0	0.010729	0	12	58									
GRK6	2870	broad.mit.edu	37	5	176863486	176863486	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:176863486C>T	uc011dfz.1	+	13	1519	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	GRK6_uc003mgp.2_Silent_p.F453F|GRK6_uc003mgq.2_Silent_p.F453F|GRK6_uc003mgs.1_Silent_p.F423F	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	453	AGC-kinase C-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTGAACTTCAAGCGGCTGG	0.672		NaN											0	0	0	0.008871	0	20	32									
RIPK1	8737	broad.mit.edu	37	6	3077181	3077181	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:3077181A>G	uc010jni.2	+	2	356	c.124A>G	c.(124-126)ATG>GTG	p.M42V	RIPK1_uc003muv.3_5'UTR|RIPK1_uc003muw.3_Intron|RIPK1_uc011dhs.1_Missense_Mutation_p.M42V|RIPK1_uc003mux.2_Missense_Mutation_p.M42V	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	42	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				CCAGGGACTCATGATCATGAA	0.527		NaN											0	0	0	0.006122	0	17	33									
GCNT2	2651	broad.mit.edu	37	6	10626656	10626656	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10626656A>G	uc010joo.2	+	5	1576	c.1025A>G	c.(1024-1026)TAT>TGT	p.Y342C	GCNT2_uc010jol.2_Missense_Mutation_p.Y56C|GCNT2_uc010jom.2_RNA|GCNT2_uc010jop.2_RNA|GCNT2_uc003mza.2_RNA|GCNT2_uc003mzc.3_Missense_Mutation_p.Y341C|GCNT2_uc003mzd.2_Missense_Mutation_p.Y340C|GCNT2_uc003mze.2_Missense_Mutation_p.Y342C	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	342	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GCAGGCCACTATGTACATGGT	0.398		NaN											0	0	0	0.00499	0	17	167									
TMEM14C	51522	broad.mit.edu	37	6	10726149	10726149	+	Missense_Mutation	SNP	C	C	T	rs146638335		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10726149C>T	uc003mzh.2	+	4	288	c.107C>T	c.(106-108)CCG>CTG	p.P36L	TMEM14C_uc010joq.1_Missense_Mutation_p.P36L|TMEM14C_uc003mzi.2_Missense_Mutation_p.P36L	NM_016462	NP_057546	Q9P0S9	TM14C_HUMAN	transmembrane protein 14C	36	Helical; (Potential).				heme biosynthetic process	integral to membrane|mitochondrial membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.135)	Epithelial(50;0.246)			GGCAGCGTGCCGTCCCTGGCT	0.547		NaN											0	0	0	0.013537	0	11	178									
DEK	7913	broad.mit.edu	37	6	18256002	18256002	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:18256002C>G	uc003ncr.1	-	6	726	c.533G>C	c.(532-534)AGG>ACG	p.R178T	DEK_uc011djf.1_Missense_Mutation_p.R144T|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	178	SAP.				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			ATTCAAGATCCTCTTCACTAG	0.333		NaN	T	NUP214	AML								0	0	0	0.020292	0	14	231									
PGBD1	84547	broad.mit.edu	37	6	28269137	28269137	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:28269137C>G	uc003nky.2	+	7	1876	c.1506C>G	c.(1504-1506)TTC>TTG	p.F502L	PGBD1_uc003nkz.2_Missense_Mutation_p.F502L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	502					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AATTGATTTTCTCAAACCTGC	0.373		NaN											0	0	0	0.01441	0	47	117									
PGBD1	84547	broad.mit.edu	37	6	28269477	28269477	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:28269477G>A	uc003nky.2	+	7	2216	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	PGBD1_uc003nkz.2_Missense_Mutation_p.E616K	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	616					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGTTCTTTTAGAGAGAGGTCA	0.418		NaN											0	0	0	0.01441	0	50	115									
VPS52	6293	broad.mit.edu	37	6	33235699	33235699	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:33235699C>G	uc003odm.1	-	9	1086	c.876G>C	c.(874-876)CTG>CTC	p.L292L	VPS52_uc003odn.1_Silent_p.L167L|VPS52_uc003odo.1_Silent_p.L217L|VPS52_uc011dqy.1_Silent_p.L167L|VPS52_uc011dqz.1_Silent_p.L167L	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	292					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						AAATCTTGCTCAGCGTCTCCA	0.522		NaN											0	0	0	0.008361	0	29	44									
DST	667	broad.mit.edu	37	6	56464869	56464869	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:56464869C>A	uc003pdf.2	-	39	5363	c.5335G>T	c.(5335-5337)GAG>TAG	p.E1779*	DST_uc003pcz.3_Nonsense_Mutation_p.E1601*|DST_uc011dxj.1_Nonsense_Mutation_p.E1630*|DST_uc011dxk.1_Nonsense_Mutation_p.E1641*|DST_uc003pcy.3_Nonsense_Mutation_p.E1275*|DST_uc010kaa.1_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3687					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AATTCTACCTCTTGCTTGGAC	0.358		NaN											1	0	2.17888e-05	0.006214	2.25107e-05	9	65									
TMEM200A	114801	broad.mit.edu	37	6	130762710	130762710	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:130762710G>T	uc003qca.2	+	3	2014	c.1143G>T	c.(1141-1143)CAG>CAT	p.Q381H	TMEM200A_uc010kfh.2_Missense_Mutation_p.Q381H|TMEM200A_uc010kfi.2_Missense_Mutation_p.Q381H|TMEM200A_uc003qcb.2_Missense_Mutation_p.Q381H	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	381	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCAGAAGACAGTTTGGGTCCA	0.522		NaN											1	0	2.35188e-11	0.006122	2.58556e-11	19	35									
KIAA1244	57221	broad.mit.edu	37	6	138645190	138645190	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:138645190G>C	uc003qhu.2	+	31	4900	c.4900G>C	c.(4900-4902)GAG>CAG	p.E1634Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1634					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CAGCGGCACGGAGAGCTTCAG	0.652		NaN											0	0	0	0.020292	0	14	37									
GRM1	2911	broad.mit.edu	37	6	146673612	146673612	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:146673612G>C	uc010khw.1	+	5	1883	c.1413G>C	c.(1411-1413)GAG>GAC	p.E471D	GRM1_uc010khv.1_Missense_Mutation_p.E471D|GRM1_uc003qll.2_Missense_Mutation_p.E471D|GRM1_uc011edz.1_Missense_Mutation_p.E471D|GRM1_uc011eea.1_Missense_Mutation_p.E471D	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	471	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGTTTGATGAGAAAGGAGACG	0.493		NaN											0	0	0	0.01441	0	54	110									
TIAM2	26230	broad.mit.edu	37	6	155485726	155485726	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:155485726C>T	uc003qqb.2	+	10	3479	c.2206C>T	c.(2206-2208)CAT>TAT	p.H736Y	TIAM2_uc003qqe.2_Missense_Mutation_p.H736Y|TIAM2_uc010kjj.2_Missense_Mutation_p.H269Y|TIAM2_uc003qqf.2_Missense_Mutation_p.H88Y|TIAM2_uc011efl.1_Missense_Mutation_p.H48Y|TIAM2_uc003qqg.2_Missense_Mutation_p.H48Y	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	736					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TTCCTCTTTCCATGCTCTGGT	0.597		NaN											0	0	0	0.016522	0	23	117									
TXNDC3	51314	broad.mit.edu	37	7	37934072	37934072	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:37934072G>C	uc003tfn.2	+	16	1776	c.1404G>C	c.(1402-1404)CAG>CAC	p.Q468H		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	468	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCTTAGAGCAGATCCTGAAGA	0.328		NaN							Kartagener_syndrome				0	0	0	0.016723	0	13	40									
SEMA3D	223117	broad.mit.edu	37	7	84628906	84628906	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:84628906G>A	uc003uic.2	-	17	2224	c.2184C>T	c.(2182-2184)GAC>GAT	p.D728D	SEMA3D_uc010led.2_Silent_p.D728D|SEMA3D_uc003uib.2_Silent_p.D367D	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	728					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CGCAGTACTGGTCGAGGCTGA	0.502		NaN											0	0	0	0.004007	0	17	64									
PON3	5446	broad.mit.edu	37	7	94989396	94989396	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:94989396G>A	uc003unt.2	-	9	979	c.954C>T	c.(952-954)ACC>ACT	p.T318T	PON1_uc011kih.1_Intron	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	318					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TGGCATACACGGTGCTCACCC	0.443		NaN											0	0	0	0.008361	0	30	46									
TECPR1	25851	broad.mit.edu	37	7	97862208	97862208	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:97862208G>A	uc003upg.2	-	12	1954	c.1749C>T	c.(1747-1749)TTC>TTT	p.F583F	TECPR1_uc003uph.1_Silent_p.F513F	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	583						integral to membrane	protein binding			pancreas(1)	1						TGAGCTGCTGGAAGATCTGCT	0.632		NaN											0	0	0	0.014758	0	5	21									
LAMB1	3912	broad.mit.edu	37	7	107601691	107601691	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:107601691G>A	uc003vew.2	-	17	2404	c.2069C>T	c.(2068-2070)TCT>TTT	p.S690F	LAMB1_uc003vev.2_Missense_Mutation_p.S714F|LAMB1_uc003vex.2_Missense_Mutation_p.S690F	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	690	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCGCTATCAGAGGAGGTGTA	0.547		NaN											0	0	0	0.013537	0	11	51									
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507		NaN											0	0	0	0.01441	0	11	34									
ZC3HC1	51530	broad.mit.edu	37	7	129688905	129688905	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:129688905C>G	uc003vpi.2	-	2	253	c.226G>C	c.(226-228)GAA>CAA	p.E76Q		NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	76					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					AAGAAGGCTTCTTTGCTTGTA	0.408		NaN											0	0	0	0.013726	0	32	61									
DENND2A	27147	broad.mit.edu	37	7	140255469	140255469	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:140255469C>G	uc010lnj.2	-	10	2149	c.2004G>C	c.(2002-2004)GTG>GTC	p.V668V	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.V668V|DENND2A_uc003vvw.2_Silent_p.V668V|DENND2A_uc003vvx.2_Silent_p.V668V	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	668	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CCAGGCGGCTCACAATGCAGT	0.522		NaN											0	0	0	0.012319	0	20	72									
C7orf33	202865	broad.mit.edu	37	7	148312489	148312489	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:148312489G>A	uc003wew.2	+	3	891	c.530G>A	c.(529-531)AGT>AAT	p.S177N		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	177										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACTGACAGCAGTTAAGAATTT	0.378		NaN											0	0	0	0.008871	0	20	72									
KRBA1	84626	broad.mit.edu	37	7	149421876	149421876	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:149421876C>G	uc003wfz.2	+	9	1461	c.1062C>G	c.(1060-1062)CTC>CTG	p.L354L	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.L22L	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	354										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCAGCCCCTCAGTCCCTCAG	0.562		NaN											0	0	0	0.009096	0	4	7									
MLL3	58508	broad.mit.edu	37	7	151902229	151902229	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:151902229G>C	uc003wla.2	-	25	4142	c.3923C>G	c.(3922-3924)TCA>TGA	p.S1308*	MLL3_uc003wkz.2_Nonsense_Mutation_p.S369*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1308					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AATAGAGCCTGAGGAATCTTT	0.358		NaN	N		medulloblastoma								0	0	0	0.014758	0	5	25									
DPP6	1804	broad.mit.edu	37	7	154659794	154659794	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:154659794G>T	uc003wlk.2	+	18	1933	c.1804G>T	c.(1804-1806)GAT>TAT	p.D602Y	DPP6_uc003wli.2_Missense_Mutation_p.D538Y|DPP6_uc003wlm.2_Missense_Mutation_p.D540Y|DPP6_uc011kvq.1_Missense_Mutation_p.D495Y	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	602	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CATTGAGATTGATGATTACAG	0.413		NaN											1	0	0.00909568	0.009096	0.00917594	4	12									
DLC1	10395	broad.mit.edu	37	8	12957784	12957784	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:12957784A>T	uc003wwm.2	-	9	2506	c.2062T>A	c.(2062-2064)TCA>ACA	p.S688T	DLC1_uc003wwk.1_Missense_Mutation_p.S251T|DLC1_uc003wwl.1_Missense_Mutation_p.S285T|DLC1_uc011kxx.1_Missense_Mutation_p.S177T	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	688					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CCCAGCTTTGAGGGCGCTTTG	0.562		NaN											0	0	0	0.007413	0	19	28									
ST18	9705	broad.mit.edu	37	8	53126796	53126796	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:53126796T>C	uc003xqz.2	-	2	178	c.22A>G	c.(22-24)AAA>GAA	p.K8E	ST18_uc011ldq.1_Translation_Start_Site|ST18_uc011ldr.1_Translation_Start_Site|ST18_uc011lds.1_Translation_Start_Site|ST18_uc003xra.2_Missense_Mutation_p.K8E|ST18_uc003xrb.2_Missense_Mutation_p.K8E|ST18_uc010lyb.2_RNA	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	8						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CGCAGCGTTTTATCTTCAGCC	0.428		NaN											0	0	0	0.007291	0	29	47									
RPS20	6224	broad.mit.edu	37	8	56986683	56986683	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:56986683C>T	uc003xsn.2	-	2	237	c.39G>A	c.(37-39)CCG>CCA	p.P13P	RPS20_uc003xsm.2_Silent_p.P13P|SNORD54_uc003xso.1_5'Flank|RPS20_uc011lea.1_5'Flank	NM_001023	NP_001014	P60866	RS20_HUMAN	ribosomal protein S20 isoform 2	13					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			TTGCCACCTCCGGCTCCACGG	0.463		NaN											0	0	0	0.010729	0	11	98									
PENK	5179	broad.mit.edu	37	8	57354059	57354059	+	Silent	SNP	G	G	A	rs145346210		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:57354059G>A	uc003xsz.2	-	2	657	c.576C>T	c.(574-576)GGC>GGT	p.G192G	PENK_uc003xta.3_Silent_p.G192G	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	192					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTCTCTTTAAGCCTCTCATGA	0.527		NaN											0	0	0	0.01441	0	60	78									
PREX2	80243	broad.mit.edu	37	8	69005891	69005891	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:69005891C>T	uc003xxv.1	+	21	2329	c.2302C>T	c.(2302-2304)CTT>TTT	p.L768F	PREX2_uc003xxu.1_Missense_Mutation_p.L768F|PREX2_uc011lez.1_Missense_Mutation_p.L703F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	768					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.L768I(1)		skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TCAAGAAGACCTTCAAAAATC	0.408		NaN											0	0	0	0.00499	0	18	141									
EYA1	2138	broad.mit.edu	37	8	72211939	72211939	+	Silent	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:72211939T>A	uc003xys.3	-	7	860	c.573A>T	c.(571-573)ACA>ACT	p.T191T	EYA1_uc003xyr.3_Silent_p.T186T|EYA1_uc003xyt.3_Silent_p.T158T|EYA1_uc010lzf.2_Silent_p.T118T|EYA1_uc003xyu.2_Silent_p.T191T|EYA1_uc011lfe.1_Silent_p.T185T|EYA1_uc003xyv.2_Silent_p.T69T	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	191					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TTCCTGATGATGTTGTAAAAC	0.318		NaN											0	0	0	0.020292	0	13	91									
JPH1	56704	broad.mit.edu	37	8	75156998	75156998	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:75156998C>T	uc003yae.2	-	4	1711	c.1671G>A	c.(1669-1671)CTG>CTA	p.L557L	JPH1_uc003yaf.2_Silent_p.L557L|JPH1_uc003yag.1_Silent_p.L421L	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	557	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GGGGGGCGTTCAGCTTCACGT	0.602		NaN											0	0	0	0.006122	0	18	97									
MATN2	4147	broad.mit.edu	37	8	98943551	98943551	+	Silent	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:98943551G>C	uc003yic.2	+	3	744	c.513G>C	c.(511-513)GGG>GGC	p.G171G	MATN2_uc003yib.1_Silent_p.G171G|MATN2_uc010mbh.1_Silent_p.G171G|MATN2_uc003yid.2_Silent_p.G171G|MATN2_uc003yie.1_Silent_p.G171G|MATN2_uc010mbi.1_Silent_p.G45G	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	171	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGACAGATGGGAGACCTCAGG	0.582		NaN											0	0	0	0.006214	0	7	31									
RGS22	26166	broad.mit.edu	37	8	101074892	101074892	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:101074892C>G	uc003yjb.1	-	9	1636	c.1441G>C	c.(1441-1443)GAT>CAT	p.D481H	RGS22_uc003yja.1_Missense_Mutation_p.D300H|RGS22_uc003yjc.1_Missense_Mutation_p.D469H|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	481					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTGATCCATCTAACAGTTTA	0.308		NaN											0	0	0	0.001168	0	5	115									
RGS22	26166	broad.mit.edu	37	8	101074973	101074973	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:101074973C>T	uc003yjb.1	-	9	1555	c.1360G>A	c.(1360-1362)GAG>AAG	p.E454K	RGS22_uc003yja.1_Missense_Mutation_p.E273K|RGS22_uc003yjc.1_Missense_Mutation_p.E442K|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	454					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTCATCTTCTCAAGATGTCTG	0.313		NaN											0	0	0	0.014758	0	5	92									
LRP12	29967	broad.mit.edu	37	8	105511547	105511547	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:105511547G>A	uc003yma.2	-	4	568	c.473C>T	c.(472-474)TCA>TTA	p.S158L	LRP12_uc003ymb.2_Missense_Mutation_p.S139L	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	158	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAACACACCTGAAAAATATGC	0.353		NaN											0	0	0	0.004482	0	8	123									
COL22A1	169044	broad.mit.edu	37	8	139691860	139691860	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:139691860C>T	uc003yvd.2	-	40	3519	c.3072G>A	c.(3070-3072)AAG>AAA	p.K1024K	COL22A1_uc011ljo.1_Intron	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1024	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTCACTGACCTTAACACATT	0.348		NaN								HNSCC(7;0.00092)			0	0	0	0.013537	0	12	70									
SHARPIN	81858	broad.mit.edu	37	8	145154091	145154091	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:145154091G>A	uc003zba.2	-	7	1424	c.940C>T	c.(940-942)CAG>TAG	p.Q314*	SHARPIN_uc003zbb.2_Intron	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	314					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGGGGTGCTGAGGGCTAGGT	0.672		NaN											0	0	0	0.016723	0	13	18									
ZNF7	7553	broad.mit.edu	37	8	146068516	146068516	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:146068516C>G	uc003zeg.3	+	5	2161	c.2024C>G	c.(2023-2025)TCA>TGA	p.S675*	ZNF7_uc010mge.2_Nonsense_Mutation_p.S686*|ZNF7_uc011lln.1_Nonsense_Mutation_p.S579*|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Nonsense_Mutation_p.S579*|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	675	C2H2-type 15.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		AATCGTAGCTCAAGGCTTACC	0.358		NaN											0	0	0	0.01441	0	62	83									
RFX3	5991	broad.mit.edu	37	9	3263030	3263030	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:3263030G>A	uc003zhr.2	-	14	1822	c.1510C>T	c.(1510-1512)CAC>TAC	p.H504Y	RFX3_uc010mhd.2_Missense_Mutation_p.H504Y|RFX3_uc003zhs.1_Missense_Mutation_p.H504Y	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	504					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TGGGCCAGGTGATTAAGCGAC	0.493		NaN											0	0	0	0.00623	0	42	38									
GLIS3	169792	broad.mit.edu	37	9	4118290	4118290	+	Silent	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:4118290T>C	uc003zhw.1	-	3	917	c.723A>G	c.(721-723)CAA>CAG	p.Q241Q	GLIS3_uc003zhx.1_Silent_p.Q396Q|GLIS3_uc003zic.1_Silent_p.Q396Q|GLIS3_uc003zie.1_Silent_p.Q396Q|GLIS3_uc010mhh.1_Silent_p.Q271Q|GLIS3_uc003zid.1_Silent_p.Q174Q|GLIS3_uc010mhi.1_Silent_p.Q203Q|GLIS3_uc003zif.1_Silent_p.Q174Q|GLIS3_uc003zig.1_Silent_p.Q240Q|GLIS3_uc003zih.1_Silent_p.Q174Q|GLIS3_uc003zhy.1_Silent_p.Q174Q|GLIS3_uc003zhz.1_Silent_p.Q174Q|GLIS3_uc003zib.1_Silent_p.Q240Q|GLIS3_uc010mhg.1_Silent_p.Q174Q	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	241					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCTCCAGCTGTTGCATGCGCT	0.731		NaN											0	0	0	0.004672	0	3	1									
CNTNAP3	79937	broad.mit.edu	37	9	39109271	39109271	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:39109271T>C	uc004abi.2	-	15	2490	c.2251A>G	c.(2251-2253)ATA>GTA	p.I751V	CNTNAP3_uc004abj.2_Missense_Mutation_p.I750V|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.I751V	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	751	Fibrinogen C-terminal.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGGACTATTGTGTCACTA	0.433		NaN											0	0	0	0.010729	0	11	8									
PRUNE2	158471	broad.mit.edu	37	9	79441572	79441572	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:79441572C>G	uc010mpk.2	-	5	709	c.585G>C	c.(583-585)CTG>CTC	p.L195L	PRUNE2_uc004akn.2_Silent_p.L195L	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	195					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATTTTTCTTCCAGGATAGAAA	0.443		NaN											0	0	0	0.003163	0	16	88									
OGN	4969	broad.mit.edu	37	9	95152326	95152326	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:95152326C>G	uc004asa.2	-	5	675	c.440G>C	c.(439-441)AGA>ACA	p.R147T	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|OGN_uc004asb.2_Missense_Mutation_p.R147T|OGN_uc011ltx.1_Missense_Mutation_p.R165T	NM_014057	NP_054776	P20774	MIME_HUMAN	osteoglycin preproprotein	147	LRR 2.					extracellular space|proteinaceous extracellular matrix	growth factor activity				0						AAAATCGAGTCTTCTTAAGTT	0.294		NaN											0	0	0	0.020292	0	13	33									
BICD2	23299	broad.mit.edu	37	9	95481333	95481333	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:95481333C>T	uc004aso.1	-	5	1651	c.1594G>A	c.(1594-1596)GAG>AAG	p.E532K	BICD2_uc004asp.1_Missense_Mutation_p.E532K	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	532	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						GCCAGCTCCTCACTGAAGGTC	0.632		NaN											0	0	0	0.008361	0	28	28									
LPPR1	54886	broad.mit.edu	37	9	104048468	104048468	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:104048468G>C	uc004bbb.2	+	4	734	c.335G>C	c.(334-336)GGA>GCA	p.G112A	LPPR1_uc011lvi.1_Missense_Mutation_p.G88A|LPPR1_uc004bbc.2_Missense_Mutation_p.G112A|LPPR1_uc010mtc.2_Missense_Mutation_p.G96A	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	112						integral to membrane	catalytic activity				0						ATTCTGACCGGAGAATGCTGT	0.373		NaN											0	0	0	0.020292	0	15	53									
RGS3	5998	broad.mit.edu	37	9	116346235	116346235	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:116346235C>T	uc004bhq.2	+	21	2752	c.2543C>T	c.(2542-2544)GCG>GTG	p.A848V	RGS3_uc004bhs.2_Missense_Mutation_p.A738V|RGS3_uc004bht.2_Missense_Mutation_p.A567V|RGS3_uc010muy.2_Intron|RGS3_uc004bhv.2_Missense_Mutation_p.A169V|RGS3_uc010muz.1_Missense_Mutation_p.A187V|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.A158V|RGS3_uc004bhx.2_Missense_Mutation_p.A169V|RGS3_uc004bhy.1_Missense_Mutation_p.A158V|RGS3_uc004bhz.2_Missense_Mutation_p.A190V	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	848					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						GACCCACCTGCGGCCCCCAGG	0.617		NaN											0	0	0	0.006999	0	41	49									
DDX31	64794	broad.mit.edu	37	9	135523856	135523856	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:135523856T>A	uc004cbq.1	-	10	1290	c.1138A>T	c.(1138-1140)AGT>TGT	p.S380C	DDX31_uc010mzu.1_Missense_Mutation_p.S380C|DDX31_uc004cbr.1_Missense_Mutation_p.S380C	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	380	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CGCAGCCGACTAAAATGAATG	0.433		NaN											0	0	0	0.00623	0	37	112									
KDM6A	7403	broad.mit.edu	37	X	44870231	44870231	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:44870231G>T	uc004dge.3	+	5	785	c.410G>T	c.(409-411)GGT>GTT	p.G137V	KDM6A_uc010nhk.2_Missense_Mutation_p.G137V|KDM6A_uc011mkz.1_Missense_Mutation_p.G137V|KDM6A_uc011mla.1_Missense_Mutation_p.G137V|KDM6A_uc011mlb.1_Missense_Mutation_p.G137V|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	137	TPR 2.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATGGTCTTGGTTTGGTCTAC	0.299		NaN	D|N|F|S		renal|oesophageal SCC|MM								1	0	5.18039e-06	0.00308	5.4173e-06	6	6									
WNK3	65267	broad.mit.edu	37	X	54265480	54265480	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:54265480G>A	uc004dtd.1	-	18	4143	c.3704C>T	c.(3703-3705)GCT>GTT	p.A1235V	WNK3_uc004dtc.1_Missense_Mutation_p.A1235V	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1235					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GCTTGACACAGCAGCAGGATA	0.388		NaN											0	0	0	0.004672	0	3	17									
ALAS2	212	broad.mit.edu	37	X	55050275	55050275	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:55050275G>A	uc004dua.3	-	4	468	c.330C>T	c.(328-330)GTC>GTT	p.V110V	ALAS2_uc004dub.3_Intron|ALAS2_uc004dud.3_Intron	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	110					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	TCCTTAGGCTGACTGAGACCA	0.507		NaN											0	0	0	0.004672	0	3	6									
ACRC	93953	broad.mit.edu	37	X	70811992	70811992	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:70811992C>G	uc004eae.2	+	3	581	c.80C>G	c.(79-81)TCA>TGA	p.S27*	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	27						nucleus				ovary(3)	3	Renal(35;0.156)					AATGTTCAGTCAAGCAGTGAT	0.383		NaN											0	0	0	0.00499	0	15	16									
FGF13	2258	broad.mit.edu	37	X	137790983	137790983	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:137790983A>T	uc004fam.2	-	2	957	c.295T>A	c.(295-297)TAC>AAC	p.Y99N	FGF13_uc004fan.2_Missense_Mutation_p.Y46N|FGF13_uc011mwi.1_Missense_Mutation_p.Y80N|FGF13_uc004faq.2_Missense_Mutation_p.Y109N|FGF13_uc004far.2_Missense_Mutation_p.Y80N|FGF13_uc011mwj.1_Missense_Mutation_p.Y109N|FGF13_uc011mwk.1_Missense_Mutation_p.Y53N	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	99					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CACTTACTGTAAGTGCTGTCC	0.383		NaN											0	0	0	0.012213	0	31	50									
CDR1	1038	broad.mit.edu	37	X	139866323	139866323	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:139866323G>A	uc004fbg.1	-	1	401	c.209C>T	c.(208-210)TCG>TTG	p.S70L	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	70	23 X 6 AA approximate repeats.|12.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CATAGCTTCCGAAAAATCCAG	0.453		NaN											0	0	0	0.015359	0	34	40									
PRDM16	63976	broad.mit.edu	37	1	3160668	3160668	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:3160668delG	uc001akf.2	+	3	485	c.405delG	c.(403-405)GTGfs	p.V135fs	PRDM16_uc001akc.2_Frame_Shift_Del_p.V135fs|PRDM16_uc001akd.2_Frame_Shift_Del_p.V135fs|PRDM16_uc001ake.2_Frame_Shift_Del_p.V135fs|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	135	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGACGGACGTGGAAGTGTCGC	0.557		NaN	T	EVI1	MDS|AML								NaN	NaN	NaN	NaN	NaN	23	67	---	---							
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:162326888_162326890delCAG	uc001gbv.2	+	8	1288_1290	c.901_903delCAG	c.(901-903)CAGdel	p.Q306del	NOS1AP_uc010pkr.1_In_Frame_Del_p.Q301del|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_In_Frame_Del_p.Q301del	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.512		NaN											NaN	NaN	NaN	NaN	NaN	9	227	---	---							
OR51I2	390064	broad.mit.edu	37	11	5475260	5475261	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:5475260_5475261insC	uc010qzf.1	+	1	542_543	c.542_543insC	c.(541-543)CACfs	p.H181fs	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACTGCCTGCACCCAGACATGA	0.46		NaN											NaN	NaN	NaN	NaN	NaN	34	41	---	---							
SAPS3	55291	broad.mit.edu	37	11	68331787	68331788	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:68331787_68331788insA	uc001onw.2	+	9	1129_1130	c.862_863insA	c.(862-864)GAGfs	p.E288fs	SAPS3_uc001onv.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc001ony.3_Frame_Shift_Ins_p.E288fs|SAPS3_uc001onx.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc009ysh.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc001onu.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc010rqc.1_Intron|SAPS3_uc010rqd.1_5'UTR	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	288					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			AGGCCATATAGAGATCTGCCCA	0.376		NaN											NaN	NaN	NaN	NaN	NaN	55	94	---	---							
ZNF317	57693	broad.mit.edu	37	19	9272093	9272093	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:9272093delG	uc002mku.2	+	7	2047	c.1772delG	c.(1771-1773)TGGfs	p.W591fs	ZNF317_uc002mkv.2_Frame_Shift_Del_p.W450fs|ZNF317_uc002mkw.2_Frame_Shift_Del_p.W559fs|ZNF317_uc002mkx.2_Frame_Shift_Del_p.W506fs|ZNF317_uc002mky.2_Frame_Shift_Del_p.W474fs	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATCCGTGTGGAAAAGGCTC	0.557		NaN											NaN	NaN	NaN	NaN	NaN	17	28	---	---							
SPATA2	9825	broad.mit.edu	37	20	48522186	48522187	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:48522186_48522187delGG	uc010gie.2	-	3	1882_1883	c.1532_1533delCC	c.(1531-1533)TCCfs	p.S511fs	SPATA2_uc002xuw.2_Frame_Shift_Del_p.S511fs|SPATA2_uc010zyn.1_Frame_Shift_Del_p.S374fs	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	511					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			AGAGCTGGGTGGACTTGTAGTT	0.54		NaN											NaN	NaN	NaN	NaN	NaN	10	100	---	---							
EIF4ENIF1	56478	broad.mit.edu	37	22	31884623	31884623	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:31884623delG	uc003akz.1	-	2	246	c.82delC	c.(82-84)CATfs	p.H28fs	EIF4ENIF1_uc003ala.1_Frame_Shift_Del_p.H28fs|EIF4ENIF1_uc003alb.1_Frame_Shift_Del_p.H28fs|EIF4ENIF1_uc003alc.1_Frame_Shift_Del_p.H28fs	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	28						nucleus	protein binding|protein transporter activity			ovary(1)	1						GTATAGCGATGGGGGCATTTG	0.413		NaN											NaN	NaN	NaN	NaN	NaN	33	21	---	---							
FLJ43860	389690	broad.mit.edu	37	8	142459777	142459778	+	Frame_Shift_Ins	INS	-	-	A	rs144781370	by1000genomes	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:142459777_142459778insA	uc003ywi.2	-	20	2630_2631	c.2549_2550insT	c.(2548-2550)CTGfs	p.L850fs	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	850							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GCAGACAGGCCAGCAGTGTGGT	0.678		NaN											NaN	NaN	NaN	NaN	NaN	8	2	---	---							
MAP3K15	389840	broad.mit.edu	37	X	19390910	19390910	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:19390910delC	uc004czk.1	-	23	3031	c.1394delG	c.(1393-1395)GGCfs	p.G465fs	MAP3K15_uc004czj.1_Frame_Shift_Del_p.G425fs|MAP3K15_uc004czi.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	990							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					CGAGGCCAAGCCCCGGTCTTC	0.612		NaN											NaN	NaN	NaN	NaN	NaN	20	37	---	---