Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
TNFRSF4	7293	broad.mit.edu	37	1	1149375	1149375	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:1149375C>T	uc001ade.2	-	1	138	c.133G>A	c.(133-135)GAG>AAG	p.E45K	TNFRSF4_uc001adf.2_5'UTR	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	45	Extracellular (Potential).|TNFR-Cys 1.				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGCCTGCACTCGTGGCAGCAC	0.721		NaN											0	0	0	0.004672	0	3	5									
CASZ1	54897	broad.mit.edu	37	1	10713996	10713996	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:10713996C>T	uc001aro.2	-	11	2438	c.2118G>A	c.(2116-2118)CCG>CCA	p.P706P	CASZ1_uc001arp.1_Silent_p.P706P|CASZ1_uc009vmx.2_Silent_p.P730P	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCAGCGAGGGCGGCAGCCCCA	0.667		NaN											0	0	0	0.028581	0	17	49									
DNAJC16	23341	broad.mit.edu	37	1	15860766	15860766	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:15860766G>A	uc001aws.2	+	3	322	c.202G>A	c.(202-204)GAC>AAC	p.D68N	DNAJC16_uc001awr.1_Missense_Mutation_p.D68N|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	68	Cytoplasmic (Potential).|J.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TGGAGCAGAAGACAAGTTCAT	0.413		NaN											0	0	0	0.048971	0	48	46									
DNAJC16	23341	broad.mit.edu	37	1	15863024	15863024	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:15863024G>C	uc001aws.2	+	4	409	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	DNAJC16_uc001awr.1_Missense_Mutation_p.E97Q|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	97	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGACGCTGGAGAGAACCAGGG	0.363		NaN											0	0	0	0.037714	0	31	29									
RSC1A1	6248	broad.mit.edu	37	1	15986519	15986519	+	Silent	SNP	T	T	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:15986519T>C	uc010obn.1	+	1	156	c.156T>C	c.(154-156)GCT>GCC	p.A52A	DDI2_uc001awx.1_3'UTR|DDI2_uc009voj.1_3'UTR	NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	52					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AACCTAAAGCTGTGAAGGCTT	0.448		NaN											0	0	0	0.048971	0	154	179									
ARHGEF10L	55160	broad.mit.edu	37	1	17942675	17942675	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:17942675C>T	uc001ban.2	+	9	972	c.813C>T	c.(811-813)TTC>TTT	p.F271F	ARHGEF10L_uc009vpe.1_Silent_p.F232F|ARHGEF10L_uc001bao.2_Silent_p.F232F|ARHGEF10L_uc001bap.2_Silent_p.F232F|ARHGEF10L_uc010ocr.1_Silent_p.F29F|ARHGEF10L_uc001baq.2_Silent_p.F37F|ARHGEF10L_uc010ocs.1_5'Flank|ARHGEF10L_uc001bar.2_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	271					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AAGTCTCCTTCCTGCACAGGA	0.622		NaN											0	0	0	0.054565	0	33	71									
LUZP1	7798	broad.mit.edu	37	1	23418794	23418794	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23418794C>G	uc001bgk.2	-	4	2345	c.1961G>C	c.(1960-1962)AGA>ACA	p.R654T	LUZP1_uc010odv.1_Missense_Mutation_p.R654T|LUZP1_uc001bgl.2_Missense_Mutation_p.R654T|LUZP1_uc001bgm.1_Missense_Mutation_p.R654T	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	654						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TGGCTTCTCTCTGCCACTGGA	0.483		NaN											0	0	0	0.048971	0	79	166									
LUZP1	7798	broad.mit.edu	37	1	23418882	23418882	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23418882C>T	uc001bgk.2	-	4	2257	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	LUZP1_uc010odv.1_Missense_Mutation_p.E625K|LUZP1_uc001bgl.2_Missense_Mutation_p.E625K|LUZP1_uc001bgm.1_Missense_Mutation_p.E625K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	625						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTAACCCCTTCTTTATGTGAG	0.468		NaN											0	0	0	0.048971	0	80	160									
LUZP1	7798	broad.mit.edu	37	1	23419929	23419929	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23419929C>T	uc001bgk.2	-	4	1210	c.826G>A	c.(826-828)GAA>AAA	p.E276K	LUZP1_uc010odv.1_Missense_Mutation_p.E276K|LUZP1_uc001bgl.2_Missense_Mutation_p.E276K|LUZP1_uc001bgm.1_Missense_Mutation_p.E276K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	276	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTTTCATTTTCTGATTTGTTT	0.403		NaN											0	0	0	0.045705	0	7	74									
GPN2	54707	broad.mit.edu	37	1	27212601	27212601	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:27212601C>G	uc001bnd.1	-	3	874	c.592G>C	c.(592-594)GAG>CAG	p.E198Q		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	198							GTP binding				0						TCCAGAACCTCTGTGTAGTAG	0.502		NaN											0	0	0	0.020292	0	15	38									
TMEM54	113452	broad.mit.edu	37	1	33363847	33363847	+	Silent	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:33363847C>G	uc001bwi.1	-	2	204	c.90G>C	c.(88-90)GTG>GTC	p.V30V	TMEM54_uc001bwj.1_Silent_p.V30V|TMEM54_uc001bwk.1_Silent_p.V30V	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	30	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGATGAAGCTCACATGGCCCA	0.612		NaN											0	0	0	0.076483	0	23	64									
TMEM54	113452	broad.mit.edu	37	1	33363913	33363913	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:33363913C>T	uc001bwi.1	-	2	138	c.24G>A	c.(22-24)CTG>CTA	p.L8L	TMEM54_uc001bwj.1_Silent_p.L8L|TMEM54_uc001bwk.1_Silent_p.L8L	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	8						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CGCCCACACTCAGGCCTCCTG	0.617		NaN											0	0	0	0.105934	0	12	43									
CD58	965	broad.mit.edu	37	1	117078651	117078651	+	Silent	SNP	A	A	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:117078651A>T	uc001egm.2	-	3	685	c.564T>A	c.(562-564)ACT>ACA	p.T188T	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Silent_p.T188T|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Silent_p.T188T	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	188	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		GATTGCTAAGAGTACACTGTA	0.343		NaN											0	0	0	0.014758	0	5	118									
CHD1L	9557	broad.mit.edu	37	1	146747112	146747112	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:146747112C>A	uc001epm.3	+	13	1429	c.1366C>A	c.(1366-1368)CAT>AAT	p.H456N	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.H343N|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.H362N|CHD1L_uc010ozp.1_Missense_Mutation_p.H175N|CHD1L_uc001epo.3_Missense_Mutation_p.H252N|CHD1L_uc010ozq.1_Missense_Mutation_p.H29N|CHD1L_uc009wji.2_Missense_Mutation_p.H175N	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	456	Helicase C-terminal.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					TGCCAGGGCTCATCGCATTGG	0.443		NaN											1	0	2.02796e-37	0.048971	2.19171e-37	69	72									
MTMR11	10903	broad.mit.edu	37	1	149903264	149903264	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:149903264G>A	uc001etl.3	-	13	1429	c.1178C>T	c.(1177-1179)TCA>TTA	p.S393L	MTMR11_uc001etm.1_Missense_Mutation_p.S321L|MTMR11_uc010pbm.1_Intron|MTMR11_uc010pbn.1_Silent_p.F219F	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	393	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TTCGGGGGCTGAAAGCAGCTG	0.562		NaN											0	0	0	0.09836	0	41	66									
ZNF687	57592	broad.mit.edu	37	1	151262304	151262304	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:151262304G>A	uc001exq.2	+	6	2883	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K	ZNF687_uc009wmo.2_Missense_Mutation_p.E929K|ZNF687_uc009wmp.2_Missense_Mutation_p.E929K	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	929	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCAGAAGAGGAGGAAGTACC	0.657		NaN											0	0	0	0.02938	0	6	3									
SMG5	23381	broad.mit.edu	37	1	156242175	156242175	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:156242175G>A	uc001foc.3	-	7	798	c.649C>T	c.(649-651)CAG>TAG	p.Q217*		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	217					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GTGCCCAGCTGATTGAAGGGC	0.493		NaN											0	0	0	0.021553	0	5	20									
SMG5	23381	broad.mit.edu	37	1	156243158	156243158	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:156243158G>C	uc001foc.3	-	6	777	c.628C>G	c.(628-630)CAG>GAG	p.Q210E		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	210					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TTACCAATCTGAGGAGCTACT	0.478		NaN											0	0	0	0.0918	0	23	54									
HMCN1	83872	broad.mit.edu	37	1	186106714	186106714	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:186106714G>A	uc001grq.1	+	88	13896	c.13667G>A	c.(13666-13668)TGC>TAC	p.C4556Y	HMCN1_uc001grs.1_Missense_Mutation_p.C125Y	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4556	TSP type-1 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTCGTCTGTGCAACCAGCCC	0.488		NaN											0	0	0	0.037714	0	29	37									
TRAF3IP3	80342	broad.mit.edu	37	1	209933433	209933433	+	Missense_Mutation	SNP	G	G	A	rs150331171		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:209933433G>A	uc001hho.2	+	3	339	c.49G>A	c.(49-51)GAG>AAG	p.E17K	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.E17K|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.E17K|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.E17K|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.E17K	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	17	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CCGGTGGGCTGAGAGCTATGA	0.622		NaN											0	0	0	0.038395	0	17	33									
ZP4	57829	broad.mit.edu	37	1	238053473	238053473	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:238053473T>G	uc001hym.2	-	2	179	c.179A>C	c.(178-180)AAC>ACC	p.N60T	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	60	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CAGCCCTTGGTTGTCTGGAGG	0.562		NaN											0	0	0	0.048971	0	53	56									
WDR64	128025	broad.mit.edu	37	1	241951205	241951205	+	Silent	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:241951205C>G	uc001hzf.1	+	13	1542	c.1389C>G	c.(1387-1389)CTC>CTG	p.L463L	WDR64_uc001hzg.1_Silent_p.L376L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	910										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AGCGAAGGCTCTTTGAATTAT	0.383		NaN											0	0	0	0.048971	0	77	105									
WAC	51322	broad.mit.edu	37	10	28903604	28903604	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr10:28903604C>T	uc001iuf.2	+	11	1631	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	WAC_uc001iud.2_Nonsense_Mutation_p.Q471*|WAC_uc001iue.2_Nonsense_Mutation_p.Q206*|WAC_uc001iug.2_Nonsense_Mutation_p.Q413*|WAC_uc001iuh.2_Nonsense_Mutation_p.Q468*	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	516					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						TCGAAGTCTTCAGCGCTCAAG	0.408		NaN											0	0	0	0.034045	0	26	53									
HPS6	79803	broad.mit.edu	37	10	103825676	103825676	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr10:103825676G>A	uc001kuj.2	+	1	530	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	149						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGCCCGGGCCGAGGGCCCGTC	0.736		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.009096	0	4	0									
OR51D1	390038	broad.mit.edu	37	11	4661394	4661394	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:4661394C>T	uc010qyk.1	+	1	374	c.374C>T	c.(373-375)TCA>TTA	p.S125L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	125	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCGTGGAGTCAGCTGTCCTG	0.547		NaN											0	0	0	0.064281	0	37	25									
OR51D1	390038	broad.mit.edu	37	11	4661499	4661499	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:4661499C>T	uc010qyk.1	+	1	479	c.479C>T	c.(478-480)TCT>TTT	p.S160F		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTGGACTATCTGCCCTGACC	0.532		NaN											0	0	0	0.048971	0	60	64									
CAPRIN1	4076	broad.mit.edu	37	11	34097866	34097867	+	Missense_Mutation	DNP	TG	TG	CA	rs140627436	byFrequency	TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:34097866_34097867TG>CA	uc001mvh.1	+	5	639_640	c.450_451TG>CA	c.(448-453)CTTGAG>CTCAAG	p.E151K	CAPRIN1_uc001mvg.2_Missense_Mutation_p.E151K|CAPRIN1_uc001mvi.2_Missense_Mutation_p.E151K|CAPRIN1_uc001mvj.1_Missense_Mutation_p.E70K	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	151	Potential.				negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				AAACTGTACTTGAGCTACAGTA	0.401		NaN											0	0	0	0.004672	0	26	24									
PCNXL3	399909	broad.mit.edu	37	11	65385501	65385501	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:65385501A>G	uc001oey.2	+	6	668	c.668A>G	c.(667-669)GAT>GGT	p.D223G		NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	223						integral to membrane					0						CTGGCTGGAGATGGAGCGCCC	0.622		NaN											0	0	0	0.02938	0	7	8									
SHANK2	22941	broad.mit.edu	37	11	70332827	70332827	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:70332827C>T	uc001oqc.2	-	21	3649	c.3571G>A	c.(3571-3573)GCG>ACG	p.A1191T	SHANK2_uc010rqn.1_Missense_Mutation_p.A603T|SHANK2_uc001opz.2_Missense_Mutation_p.A596T|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	812					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCGCTGCTCGCGGAGGGCACT	0.706		NaN											0	0	0	0.020292	0	15	48									
ARHGEF12	23365	broad.mit.edu	37	11	120298916	120298916	+	Missense_Mutation	SNP	C	C	G	rs147982337	by1000genomes	TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:120298916C>G	uc001pxl.1	+	8	552	c.545C>G	c.(544-546)TCT>TGT	p.S182C	ARHGEF12_uc009zat.2_Missense_Mutation_p.S163C|ARHGEF12_uc010rzn.1_Missense_Mutation_p.S79C|ARHGEF12_uc009zau.1_Missense_Mutation_p.S79C	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	182					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CCTGGAGCATCTGGGAATATG	0.458		NaN	T	MLL	AML								0	0	0	0.048971	0	73	117									
IGSF9B	22997	broad.mit.edu	37	11	133789947	133789947	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:133789947G>C	uc001qgx.3	-	18	3904	c.3673C>G	c.(3673-3675)CGC>GGC	p.R1225G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1225	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGGCCCGGGCGAGGCCGGGCA	0.677		NaN											0	0	0	0.049695	0	21	45									
CAPRIN2	65981	broad.mit.edu	37	12	30863384	30863384	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr12:30863384G>A	uc001rji.1	-	18	3587	c.2836C>T	c.(2836-2838)CAG>TAG	p.Q946*	CAPRIN2_uc001rjf.1_Silent_p.L756L|CAPRIN2_uc001rjg.1_Nonsense_Mutation_p.Q613*|CAPRIN2_uc001rjh.1_Nonsense_Mutation_p.Q896*|CAPRIN2_uc001rjj.1_Nonsense_Mutation_p.Q612*|CAPRIN2_uc001rjk.3_Silent_p.L959L|CAPRIN2_uc001rjl.3_Silent_p.L904L	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	946					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CTGCTCACCTGAGAAGAATCA	0.448		NaN											0	0	0	0.048971	0	88	153									
SELPLG	6404	broad.mit.edu	37	12	109017670	109017670	+	Silent	SNP	G	G	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr12:109017670G>T	uc001tni.2	-	2	574	c.414C>A	c.(412-414)CCC>CCA	p.P138P	SELPLG_uc001tnh.2_Intron|SELPLG_uc010sxe.1_Silent_p.P154P	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	138	2.|Extracellular (Potential).|12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						GTGCCTCCGTGGGCACTGGTT	0.612		NaN											1	0	7.26314e-15	0.034045	7.70602e-15	29	71									
CORO1C	23603	broad.mit.edu	37	12	109095087	109095087	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr12:109095087C>G	uc001tnj.2	-	2	104	c.8G>C	c.(7-9)CGA>CCA	p.R3P	CORO1C_uc009zva.2_Missense_Mutation_p.R56P|CORO1C_uc010sxf.1_Missense_Mutation_p.R3P	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	3					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						TCGTACCACTCGCCTCATCGT	0.428		NaN											0	0	0	0.080422	0	39	72									
NUDT15	55270	broad.mit.edu	37	13	48611984	48611984	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:48611984G>C	uc001vbw.1	+	1	282	c.102G>C	c.(100-102)AGG>AGC	p.R34S	SUCLA2_uc010tgd.1_5'UTR|NUDT15_uc001vbv.2_Missense_Mutation_p.R34S	NM_018283	NP_060753	Q9NV35	NUD15_HUMAN	nudix-type motif 15	34	Nudix hydrolase.						hydrolase activity|metal ion binding				0		all_cancers(8;3.75e-25)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|all_hematologic(8;0.000219)|Lung NSC(96;0.000226)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;4.83e-07)		TGGGGAAGAGGAAAGGCTCGG	0.682		NaN									OREG0022405	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	4									
RBM26	64062	broad.mit.edu	37	13	79928636	79928636	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:79928636G>C	uc001vkz.2	-	13	1944	c.1930C>G	c.(1930-1932)CCA>GCA	p.P644A	RBM26_uc001vky.2_Missense_Mutation_p.P639A|RBM26_uc001vla.2_Missense_Mutation_p.P642A|RBM26_uc010tia.1_Missense_Mutation_p.P23A|RBM26_uc001vkx.2_Missense_Mutation_p.P354A	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	642					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GAAGGTACTGGACCCAGCCGC	0.463		NaN											0	0	0	0.014758	0	4	77									
FARP1	10160	broad.mit.edu	37	13	99083532	99083532	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:99083532G>A	uc001vnj.2	+	18	2477	c.2141G>A	c.(2140-2142)CGA>CAA	p.R714Q	FARP1_uc001vnh.2_Missense_Mutation_p.R714Q	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	714	DH.		R -> L (in a breast cancer sample; somatic mutation).		regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity	p.R714L(2)		breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGGGACTGCCGAGGTGAGTGC	0.687		NaN											0	0	0	0.021553	0	4	3									
TM9SF2	9375	broad.mit.edu	37	13	100154005	100154005	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:100154005G>A	uc001voj.1	+	1	278	c.145G>A	c.(145-147)GAA>AAA	p.E49K	TM9SF2_uc010afz.1_Missense_Mutation_p.E49K	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	49	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CTTCTGCGACGAAGAAAAAAA	0.647		NaN											0	0	0	0.045705	0	30	34									
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731		NaN											0	0	0	0.004672	0	2	1									
TMEM55B	90809	broad.mit.edu	37	14	20928871	20928871	+	Silent	SNP	G	G	A	rs150985847		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:20928871G>A	uc001vxl.2	-	2	429	c.276C>T	c.(274-276)AAC>AAT	p.N92N	TMEM55B_uc001vxk.2_Silent_p.N99N	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	92						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		TGCCTTCCACGTTGATGAGAG	0.527		NaN											0	0	0	0.050027	0	32	84									
SOS2	6655	broad.mit.edu	37	14	50626242	50626242	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:50626242C>G	uc001wxs.3	-	10	1857	c.1759G>C	c.(1759-1761)GAA>CAA	p.E587Q	SOS2_uc010tql.1_Missense_Mutation_p.E554Q|SOS2_uc010tqm.1_RNA|SOS2_uc001wxt.2_Missense_Mutation_p.E275Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	587					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					AAGTTGTCTTCAAAAACAATG	0.338		NaN											0	0	0	0.039052	0	44	85									
FBXO34	55030	broad.mit.edu	37	14	55817155	55817155	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:55817155C>T	uc001xbu.2	+	2	292	c.47C>T	c.(46-48)CCG>CTG	p.P16L	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Missense_Mutation_p.P16L	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	16										ovary(2)|lung(2)|skin(1)	5						GAGCACCCCCCGGAAGTCAGC	0.423		NaN											0	0	0	0.020292	0	15	45									
PSEN1	5663	broad.mit.edu	37	14	73683862	73683862	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:73683862C>A	uc001xnr.2	+	11	1442	c.1158C>A	c.(1156-1158)TTC>TTA	p.F386L	PSEN1_uc001xnv.2_Missense_Mutation_p.F382L|PSEN1_uc010ark.2_Missense_Mutation_p.F382L|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	386	Required for interaction with CTNND2.|Required for interaction with CTNNB1.|Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		TGGGAGATTTCATTTTCTACA	0.368		NaN											1	0	5.85753e-14	0.048971	6.17703e-14	51	74									
AHNAK2	113146	broad.mit.edu	37	14	105411641	105411641	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:105411641C>T	uc010axc.1	-	7	10267	c.10147G>A	c.(10147-10149)GAG>AAG	p.E3383K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E3283K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3383						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCAGCTCCCTCGGGCACGTGG	0.632		NaN											0	0	0	0.048971	0	94	225									
TPM1	7168	broad.mit.edu	37	15	63354444	63354444	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:63354444G>C	uc002alg.2	+	7	861	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	TPM1_uc002alh.2_Missense_Mutation_p.E224Q|TPM1_uc010bgn.2_RNA|TPM1_uc002ali.2_Missense_Mutation_p.E224Q|TPM1_uc002alj.2_Missense_Mutation_p.E224Q|TPM1_uc002alk.2_Missense_Mutation_p.E224Q|TPM1_uc002all.2_Missense_Mutation_p.E224Q|TPM1_uc002alm.2_Missense_Mutation_p.E266Q|TPM1_uc010uie.1_Missense_Mutation_p.E224Q|TPM1_uc002alp.2_Missense_Mutation_p.E224Q|TPM1_uc010uif.1_Missense_Mutation_p.E188Q|TPM1_uc002alr.2_Missense_Mutation_p.E188Q|TPM1_uc002als.2_Missense_Mutation_p.E188Q|TPM1_uc010uig.1_Missense_Mutation_p.E188Q|TPM1_uc002alt.2_Missense_Mutation_p.E188Q|TPM1_uc010bgp.2_Missense_Mutation_p.E98Q	NM_001018005	NP_001018005	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 1	224	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						ATATGAGGAAGAGATCAAGGT	0.433		NaN											0	0	0	0.041601	0	28	69									
RPL4	6124	broad.mit.edu	37	15	66794183	66794183	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:66794183C>G	uc002apv.2	-	5	545	c.489G>C	c.(487-489)AAG>AAC	p.K163N	RPL4_uc010bhr.2_Missense_Mutation_p.K69N|RPL4_uc002apw.2_Missense_Mutation_p.K69N|RPL4_uc002apx.2_Missense_Mutation_p.K69N|RPL4_uc010ujq.1_Missense_Mutation_p.K163N|SNORD18C_uc010bhs.1_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	163					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						CTTCCTTGGTCTTCTTGTAGC	0.383		NaN											0	0	0	0.041601	0	31	49									
TPSG1	25823	broad.mit.edu	37	16	1271924	1271924	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:1271924G>C	uc002ckw.2	-	6	832	c.830C>G	c.(829-831)TCT>TGT	p.S277C		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	277					proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GGGGTACCCAGACTCTGAGCC	0.657		NaN											0	0	0	0.069234	0	10	22									
TPSG1	25823	broad.mit.edu	37	16	1271985	1271985	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:1271985G>A	uc002ckw.2	-	6	771	c.769C>T	c.(769-771)CGT>TGT	p.R257C		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	257	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GCAGGGACACGAGTGTAGACT	0.672		NaN											0	0	0	0.080935	0	11	28									
ITGAL	3683	broad.mit.edu	37	16	30521724	30521724	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:30521724G>A	uc002dyi.3	+	22	2727	c.2551G>A	c.(2551-2553)GAG>AAG	p.E851K	ITGAL_uc002dyj.3_Missense_Mutation_p.E767K|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	851	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GCTTCCTGAAGAGTCCAGGCT	0.532		NaN											0	0	0	0.039052	0	41	88									
IRX6	79190	broad.mit.edu	37	16	55362791	55362791	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:55362791G>C	uc002ehy.2	+	5	1434	c.901G>C	c.(901-903)GAG>CAG	p.E301Q	IRX6_uc002ehx.2_Missense_Mutation_p.E301Q	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	301						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						TGCAGCTCGAGAGGGCCGATT	0.597		NaN											0	0	0	0.069288	0	23	56									
CDH3	1001	broad.mit.edu	37	16	68716273	68716273	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:68716273C>T	uc002ewf.2	+	9	2197	c.1065C>T	c.(1063-1065)GAC>GAT	p.D355D	CDH3_uc010vli.1_Silent_p.D300D	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	355	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CTGATCTGGACGCCCCCAACT	0.592		NaN											0	0	0	0.038395	0	17	28									
CYB5B	80777	broad.mit.edu	37	16	69458658	69458658	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:69458658C>T	uc002exg.1	+	1	161	c.72C>T	c.(70-72)GTC>GTT	p.V24V	CYB5B_uc002exf.2_Silent_p.V24V|CYB5B_uc010cfl.1_Silent_p.V24V	NM_030579	NP_085056	O43169	CYB5B_HUMAN	cytochrome b5 outer mitochondrial membrane	20	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding				0		Ovarian(137;0.101)				AGACCTCAGTCACCTATTACC	0.567		NaN											0	0	0	0.034045	0	28	52									
TCF25	22980	broad.mit.edu	37	16	89967083	89967083	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:89967083C>G	uc002fpb.2	+	12	1344	c.1262C>G	c.(1261-1263)TCT>TGT	p.S421C	TCF25_uc002fpc.2_Missense_Mutation_p.S186C	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	421					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TTTGCCTTCTCTGTTCCACTG	0.532		NaN											0	0	0	0.045705	0	31	53									
DNAH2	146754	broad.mit.edu	37	17	7697658	7697658	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:7697658C>G	uc002giu.1	+	48	7670	c.7656C>G	c.(7654-7656)ATC>ATG	p.I2552M		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2552	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCAACATTATCAACATGACCT	0.592		NaN											0	0	0	0.041601	0	29	42									
CNTROB	116840	broad.mit.edu	37	17	7843441	7843441	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:7843441G>T	uc002gjq.2	+	10	2111	c.1192G>T	c.(1192-1194)GCC>TCC	p.A398S	CNTROB_uc002gjp.2_Missense_Mutation_p.A398S|CNTROB_uc002gjr.2_Missense_Mutation_p.A300S|CNTROB_uc010vum.1_Missense_Mutation_p.A110S	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	398	Potential.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				AGCCCAGGCCGCCTGGGAGAC	0.532		NaN											1	0	1.06801e-11	0.041601	1.11278e-11	31	80									
PHOSPHO1	162466	broad.mit.edu	37	17	47302012	47302012	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:47302012G>A	uc010wlv.1	-	3	766	c.400C>T	c.(400-402)CGC>TGC	p.R134C	PHOSPHO1_uc002ios.2_Missense_Mutation_p.R159C	NM_178500	NP_848595	Q8TCT1	PHOP1_HUMAN	phosphatase, orphan 1 isoform 2	134					regulation of bone mineralization		metal ion binding|phosphoethanolamine/phosphocholine phosphatase activity				0			Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)		Choline(DB00122)	CCGGCGGCGCGCAGCGAGCTC	0.657		NaN											0	0	0	0.004672	0	3	6									
KIF2B	84643	broad.mit.edu	37	17	51901070	51901070	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:51901070C>T	uc002iua.2	+	1	832	c.676C>T	c.(676-678)CGA>TGA	p.R226*	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	226	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TCTCAACCAGCGAGAGACAAC	0.557		NaN											0	0	0	0.049695	0	20	33									
ABCA9	10350	broad.mit.edu	37	17	66972297	66972297	+	Silent	SNP	G	G	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:66972297G>T	uc002jhu.2	-	38	4898	c.4755C>A	c.(4753-4755)CTC>CTA	p.L1585L	ABCA9_uc010dez.2_Silent_p.L1547L	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1585					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TAGACTGTGAGAGGCTGTACT	0.403		NaN											1	0	3.8784e-16	0.062417	4.14014e-16	21	63									
ACTG1	71	broad.mit.edu	37	17	79477994	79477994	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:79477994T>C	uc002kaj.1	-	4	968	c.943A>G	c.(943-945)AAG>GAG	p.K315E	ACTG1_uc002kah.1_Missense_Mutation_p.K193E|ACTG1_uc002kai.1_Missense_Mutation_p.K272E|ACTG1_uc002kak.1_Missense_Mutation_p.K315E|ACTG1_uc010wun.1_Missense_Mutation_p.K315E|ACTG1_uc002kal.1_Missense_Mutation_p.K315E|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	315					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			GTGATCTCCTTCTGCATCCTG	0.632		NaN											0	0	0	0.064281	0	36	66									
NPLOC4	55666	broad.mit.edu	37	17	79534448	79534448	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:79534448G>C	uc002kat.3	-	15	1743	c.1561C>G	c.(1561-1563)CTG>GTG	p.L521V	NPLOC4_uc002kau.3_Missense_Mutation_p.L521V|NPLOC4_uc010wur.1_Missense_Mutation_p.L360V|NPLOC4_uc010dic.2_5'Flank|NPLOC4_uc002kas.2_Silent_p.L44L	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	521					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CGCACCTGCAGAGGCATAACT	0.502		NaN											0	0	0	0.038147	0	8	11									
C18orf34	374864	broad.mit.edu	37	18	30554631	30554631	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr18:30554631C>G	uc002kxn.2	-	21	2545	c.2403G>C	c.(2401-2403)CAG>CAC	p.Q801H	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Missense_Mutation_p.Q265H|C18orf34_uc010xbr.1_Missense_Mutation_p.Q825H|C18orf34_uc010dmf.1_Missense_Mutation_p.Q121H|C18orf34_uc002kxo.2_Missense_Mutation_p.Q763H|C18orf34_uc002kxp.2_Missense_Mutation_p.Q801H	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	801										ovary(1)	1						GCATCCTTCTCTGCAGCTGAC	0.502		NaN											0	0	0	0.024245	0	16	16									
KIAA1632	57724	broad.mit.edu	37	18	43534669	43534669	+	Silent	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr18:43534669C>G	uc002lbm.2	-	2	799	c.699G>C	c.(697-699)GTG>GTC	p.V233V	KIAA1632_uc002lbo.1_Silent_p.V233V	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	233					autophagy						0						GCAAGGGTTTCACTGCCACCA	0.483		NaN											0	0	0	0.09836	0	41	30									
KIAA1632	57724	broad.mit.edu	37	18	43535299	43535299	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr18:43535299C>G	uc002lbm.2	-	2	169	c.69G>C	c.(67-69)AAG>AAC	p.K23N	KIAA1632_uc002lbo.1_Missense_Mutation_p.K23N	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	23					autophagy						0						CATACTTCTTCTTTTCCTAAA	0.353		NaN											0	0	0	0.080935	0	12	12									
DAPK3	1613	broad.mit.edu	37	19	3959237	3959237	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:3959237G>A	uc002lzc.1	-	8	1320	c.1227C>T	c.(1225-1227)CTC>CTT	p.L409L	DAPK3_uc002lzb.1_Silent_p.L146L|DAPK3_uc002lzd.1_Silent_p.L409L	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	409	Interaction with CDC5L (By similarity).				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGGCGCTTGAGGCCGCTGG	0.701		NaN											0	0	0	0.047766	0	8	9									
ADAMTS10	81794	broad.mit.edu	37	19	8661877	8661877	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:8661877A>G	uc002mkj.1	-	8	1308	c.1034T>C	c.(1033-1035)ATC>ACC	p.I345T	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	345	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCACCGTGTGATGAGCACTGC	0.537		NaN											0	0	0	0.108266	0	27	62									
C19orf56	51398	broad.mit.edu	37	19	12780451	12780451	+	Translation_Start_Site	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:12780451G>C	uc002mud.2	-	1	15	c.-233C>G	c.(-235--231)ATCGG>ATGGG		MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_Intron|WDR83_uc002muc.2_Intron|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398							integral to membrane					0						GTTCCAACCCGATCACCGAAA	0.458		NaN											0	0	0	0.004672	0	3	4									
WDR83	84292	broad.mit.edu	37	19	12780828	12780828	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:12780828G>A	uc002mue.3	+	4	476	c.141G>A	c.(139-141)AAG>AAA	p.K47K	WDR83_uc002muc.2_RNA|C19orf56_uc002mud.2_5'Flank|WDR83_uc010dyw.2_Silent_p.K47K	NM_001099737	NP_001093207	Q9BRX9	WDR83_HUMAN	mitogen-activated protein kinase organizer 1	47	WD 1.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2						GCAGTGACAAGACGCTGAAGC	0.677		NaN											0	0	0	0.074837	0	40	96									
NACC1	112939	broad.mit.edu	37	19	13246039	13246039	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:13246039G>C	uc002mwm.2	+	2	186	c.18G>C	c.(16-18)CAG>CAC	p.Q6H		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	6					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						AGACACTGCAGATGGAGATCC	0.627		NaN											0	0	0	0.105934	0	13	38									
ZNF492	57615	broad.mit.edu	37	19	22847622	22847622	+	Missense_Mutation	SNP	A	A	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:22847622A>C	uc002nqw.3	+	4	1395	c.1151A>C	c.(1150-1152)AAG>ACG	p.K384T		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	384	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACTACACATAAGAGAATTCAT	0.378		NaN											0	0	0	0.069288	0	16	52									
MAP4K1	11184	broad.mit.edu	37	19	39098807	39098807	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:39098807C>T	uc002oix.1	-	14	1118	c.1010G>A	c.(1009-1011)CGG>CAG	p.R337Q	MAP4K1_uc002oiw.1_5'Flank|MAP4K1_uc002oiy.1_Missense_Mutation_p.R337Q|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	337					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCCATGTGCCGCCCTAGGGT	0.602		NaN											0	0	0	0.069234	0	9	25									
MED29	55588	broad.mit.edu	37	19	39883109	39883109	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:39883109G>C	uc002olf.2	+	2	322	c.285G>C	c.(283-285)TTG>TTC	p.L95F	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Missense_Mutation_p.L95F|MED29_uc010xux.1_Intron	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	74	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ACTAGACCTTGATGAAGGTTG	0.433		NaN											0	0	0	0.076483	0	23	46									
PNMAL2	57469	broad.mit.edu	37	19	46998146	46998146	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:46998146C>T	uc002pes.2	-	1	1024	c.577G>A	c.(577-579)GAG>AAG	p.E193K	uc002peu.1_Missense_Mutation_p.S86L	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	193										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TCCTCGGCCTCACTCCTCGCG	0.647		NaN											0	0	0	0.043863	0	20	37									
KCNC3	3748	broad.mit.edu	37	19	50826951	50826951	+	Missense_Mutation	SNP	C	C	T	rs104894699		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:50826951C>T	uc002pru.1	-	2	1554	c.1259G>A	c.(1258-1260)CGC>CAC	p.R420H	KCNC3_uc002prt.1_Missense_Mutation_p.R56H	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	420	Helical; Voltage-sensor; Name=Segment S4; (Potential).		R -> H (in SCA13; loss of channel activity).		cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GCGCAGGATGCGGACGAAGCG	0.657		NaN											0	0	0	0.020292	0	12	44									
LILRA4	23547	broad.mit.edu	37	19	54849825	54849825	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:54849825G>C	uc002qfj.2	-	3	254	c.197C>G	c.(196-198)TCA>TGA	p.S66*	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	66	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCTCGACATTGAGTTTCCCTC	0.532		NaN											0	0	0	0.104719	0	40	110									
ZNF543	125919	broad.mit.edu	37	19	57840563	57840563	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:57840563C>T	uc002qoi.1	+	4	2078	c.1733C>T	c.(1732-1734)TCA>TTA	p.S578L		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	578					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCACAGACTTCAGTCAACATC	0.423		NaN											0	0	0	0.059317	0	37	62									
ASXL2	55252	broad.mit.edu	37	2	25990544	25990544	+	Nonsense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:25990544G>C	uc002rgs.2	-	7	904	c.683C>G	c.(682-684)TCA>TGA	p.S228*	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	228	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGGAGTTTGAGTTTTGAGG	0.413		NaN											0	0	0	0.069456	0	36	47									
NCKAP5	344148	broad.mit.edu	37	2	133542927	133542927	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:133542927G>A	uc002ttp.2	-	14	1831	c.1457C>T	c.(1456-1458)GCA>GTA	p.A486V	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	486							protein binding				0						TTGGAGCAATGCTAAGGTGGA	0.498		NaN											0	0	0	0.069456	0	35	79									
LRP1B	53353	broad.mit.edu	37	2	141625828	141625828	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:141625828G>A	uc002tvj.1	-	26	5146	c.4174C>T	c.(4174-4176)CTT>TTT	p.L1392F	LRP1B_uc010fnl.1_Missense_Mutation_p.L574F	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1392	Extracellular (Potential).|LDL-receptor class B 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCCAGAAAAGAATTCTaaaa	0.249		NaN								TSP Lung(27;0.18)			0	0	0	0.038395	0	10	37									
TTN	7273	broad.mit.edu	37	2	179393575	179393575	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:179393575C>T	uc010zfg.1	-	309	99423	c.99199G>A	c.(99199-99201)GAT>AAT	p.D33067N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D26762N|TTN_uc010zfi.1_Missense_Mutation_p.D26695N|TTN_uc010zfj.1_Missense_Mutation_p.D26570N|TTN_uc002umq.2_Missense_Mutation_p.D84N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33994							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTCACATCAGTGGCACCA	0.453		NaN											0	0	0	0.055883	0	20	34									
TTN	7273	broad.mit.edu	37	2	179430575	179430575	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:179430575C>T	uc010zfg.1	-	275	72804	c.72580G>A	c.(72580-72582)GAA>AAA	p.E24194K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17889K|TTN_uc010zfi.1_Missense_Mutation_p.E17822K|TTN_uc010zfj.1_Missense_Mutation_p.E17697K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25121							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCAAATTCATTTTCAGCC	0.433		NaN											0	0	0	0.048971	0	73	187									
IKZF2	22807	broad.mit.edu	37	2	213872226	213872226	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:213872226A>G	uc002vem.2	-	8	1608	c.1439T>C	c.(1438-1440)TTC>TCC	p.F480S	IKZF2_uc010fuu.2_Missense_Mutation_p.F335S|IKZF2_uc002vej.2_Missense_Mutation_p.F427S|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.F406S|IKZF2_uc002vel.2_Missense_Mutation_p.F401S|IKZF2_uc010fuw.2_Missense_Mutation_p.F254S|IKZF2_uc010fux.2_Missense_Mutation_p.F254S|IKZF2_uc010fuy.2_Missense_Mutation_p.F408S|IKZF2_uc002ven.2_Missense_Mutation_p.F454S|IKZF2_uc002vei.2_Missense_Mutation_p.F258S	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	480	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		ATGGTCTAGGAAAAGGACTCG	0.512		NaN											0	0	0	0.055883	0	19	119									
RNPEPL1	57140	broad.mit.edu	37	2	241514466	241514466	+	Silent	SNP	G	G	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:241514466G>T	uc002vzi.2	+	7	1208	c.615G>T	c.(613-615)CTG>CTT	p.L205L	RNPEPL1_uc010fzf.2_Silent_p.L111L|RNPEPL1_uc002vzj.2_5'Flank	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	205					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CCAGCCACCTGATGAACCTGT	0.587		NaN											1	0	3.41278e-10	0.0333	3.51375e-10	15	112									
KCNB1	3745	broad.mit.edu	37	20	48098781	48098781	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr20:48098781G>A	uc002xur.1	-	1	401	c.237C>T	c.(235-237)GAC>GAT	p.D79D	KCNB1_uc002xus.1_Silent_p.D79D	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	79	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ACTCGTTGTCGTCGAGGCTGT	0.647		NaN											0	0	0	0.028581	0	16	21									
NFATC2	4773	broad.mit.edu	37	20	50051848	50051848	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr20:50051848T>C	uc002xwd.2	-	8	2129	c.1909A>G	c.(1909-1911)ATG>GTG	p.M637V	NFATC2_uc002xwc.2_Missense_Mutation_p.M637V|NFATC2_uc010zyv.1_Missense_Mutation_p.M418V|NFATC2_uc010zyw.1_Missense_Mutation_p.M418V|NFATC2_uc010zyx.1_Missense_Mutation_p.M617V|NFATC2_uc010zyy.1_Missense_Mutation_p.M418V|NFATC2_uc010zyz.1_Missense_Mutation_p.M418V|NFATC2_uc002xwe.2_Missense_Mutation_p.M617V	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	637					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					ACAAAAAGCATGTTCTATAAG	0.453		NaN											0	0	0	0.048971	0	51	103									
SRMS	6725	broad.mit.edu	37	20	62173828	62173828	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr20:62173828C>T	uc002yfi.1	-	4	793	c.752G>A	c.(751-753)GGC>GAC	p.G251D		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	251	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GGGCAGGGAGCCCAGCCACAG	0.672		NaN											0	0	0	0.080935	0	10	24									
RWDD2B	10069	broad.mit.edu	37	21	30380387	30380387	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr21:30380387G>A	uc002yms.2	-	4	507	c.420C>T	c.(418-420)TTC>TTT	p.F140F	RWDD2B_uc002ymt.2_Silent_p.F111F|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Silent_p.F60F	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	140	RWD.										0						GTTTTTGCAGGAATGCAGTCA	0.398		NaN											0	0	0	0.055883	0	20	59									
RSPH1	89765	broad.mit.edu	37	21	43897508	43897508	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr21:43897508G>A	uc002zbg.2	-	7	725	c.620C>T	c.(619-621)CCA>CTA	p.P207L		NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	207					meiosis	cytosol|nucleus				ovary(1)	1						TTTCCATTTTGGAACAACAGT	0.453		NaN											0	0	0	0.054565	0	30	61									
SLC19A1	6573	broad.mit.edu	37	21	46951324	46951324	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr21:46951324C>T	uc002zhl.1	-	3	1047	c.928G>A	c.(928-930)GAT>AAT	p.D310N	SLC19A1_uc010gpy.1_Missense_Mutation_p.D310N|SLC19A1_uc011aft.1_Missense_Mutation_p.D270N|SLC19A1_uc002zhm.1_Missense_Mutation_p.D310N|SLC19A1_uc010gpz.1_Missense_Mutation_p.D189N	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	310	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GAGGCAGCATCTGCCGCGCCG	0.662		NaN											0	0	0	0.037714	0	28	78									
THOC5	8563	broad.mit.edu	37	22	29917011	29917011	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr22:29917011T>C	uc003afr.2	-	14	1588	c.1253A>G	c.(1252-1254)AAT>AGT	p.N418S	THOC5_uc003afq.2_Missense_Mutation_p.N79S|THOC5_uc003afs.2_Missense_Mutation_p.N418S|THOC5_uc003aft.2_Missense_Mutation_p.N418S|THOC5_uc003afu.2_Missense_Mutation_p.N418S|THOC5_uc010gvo.2_Missense_Mutation_p.N162S	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	418					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						CTGATACTGATTGGCTGGATT	0.463		NaN											0	0	0	0.048971	0	67	153									
ASCC2	84164	broad.mit.edu	37	22	30198142	30198142	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr22:30198142G>A	uc003agr.2	-	14	1514	c.1409C>T	c.(1408-1410)TCT>TTT	p.S470F	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Missense_Mutation_p.S470F|ASCC2_uc011akr.1_Missense_Mutation_p.S394F	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	470	CUE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GGAGATGAGAGAGTCCAGTTC	0.607		NaN											0	0	0	0.037714	0	27	46									
APOBEC3H	164668	broad.mit.edu	37	22	39497957	39497957	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr22:39497957C>T	uc011aoh.1	+	4	519	c.453C>T	c.(451-453)CAC>CAT	p.H151H	APOBEC3H_uc011aoi.1_RNA|APOBEC3H_uc003axa.3_RNA	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	151					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					TTGTGGACCACGAGAAACCGC	0.522		NaN											0	0	0	0.030593	0	28	52									
LRRN1	57633	broad.mit.edu	37	3	3886477	3886477	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:3886477G>A	uc003bpt.3	+	2	913	c.152G>A	c.(151-153)AGA>AAA	p.R51K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	51	LRRNT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCAACTTACAGAGAAGCCACC	0.438		NaN											0	0	0	0.080422	0	37	92									
IL17RC	84818	broad.mit.edu	37	3	9974314	9974314	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:9974314C>T	uc003bua.2	+	17	1859	c.1623C>T	c.(1621-1623)CTC>CTT	p.L541L	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_Silent_p.L470L|IL17RC_uc011atp.1_Silent_p.L309L|IL17RC_uc003bud.2_Silent_p.L11L|IL17RC_uc003bub.2_Silent_p.L455L|IL17RC_uc010hct.2_Silent_p.L470L|IL17RC_uc010hcu.2_Silent_p.L453L|IL17RC_uc010hcv.2_Silent_p.L438L|IL17RC_uc011atq.1_Silent_p.L455L|IL17RC_uc003buc.2_Silent_p.L11L|IL17RC_uc003bue.2_Silent_p.L106L|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank|CRELD1_uc003buj.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	541	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GCTGGGCCCTCGTGTGGCTGG	0.532		NaN									OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.054565	0	32	77									
SMARCC1	6599	broad.mit.edu	37	3	47717003	47717003	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:47717003G>C	uc003crq.2	-	18	1919	c.1801C>G	c.(1801-1803)CTC>GTC	p.L601V	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.L492V	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	601					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TCAGTACGGAGACCAAAGTTC	0.378		NaN											0	0	0	0.038395	0	16	36									
IP6K2	51447	broad.mit.edu	37	3	48732710	48732710	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:48732710G>A	uc003cup.2	-	2	259	c.15C>T	c.(13-15)TTC>TTT	p.F5F	IP6K2_uc003cuq.2_Silent_p.F5F|IP6K2_uc011bbq.1_Silent_p.F5F|IP6K2_uc011bbr.1_Silent_p.F5F|IP6K2_uc003cur.2_Silent_p.F5F|IP6K2_uc003cus.2_Silent_p.F5F|IP6K2_uc003cut.2_RNA|IP6K2_uc011bbs.1_RNA|IP6K2_uc011bbt.1_Silent_p.F60F|IP6K2_uc003cuv.1_Nonsense_Mutation_p.Q131*|IP6K2_uc011bbu.1_Silent_p.F59F|IP6K2_uc011bbv.1_Silent_p.F63F|IP6K2_uc003cuw.1_Nonsense_Mutation_p.Q130*	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	5					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						CCATGGCCCTGAAGGCTGGGC	0.637		NaN											0	0	0	0.069288	0	24	26									
ACTR8	93973	broad.mit.edu	37	3	53907147	53907147	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:53907147G>A	uc003dhd.2	-	9	1132	c.1073C>T	c.(1072-1074)TCT>TTT	p.S358F	ACTR8_uc003dhb.2_Missense_Mutation_p.S63F|ACTR8_uc003dhc.2_Missense_Mutation_p.S247F	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	358					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CTGAAGCCCAGAGATGTCCTG	0.418		NaN											0	0	0	0.080935	0	10	14									
OR5H14	403273	broad.mit.edu	37	3	97868522	97868522	+	Missense_Mutation	SNP	A	A	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:97868522A>C	uc003dsg.1	+	1	293	c.293A>C	c.(292-294)AAG>ACG	p.K98T		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTGAATGCAAGATACAGTTG	0.383		NaN											0	0	0	0.048971	0	100	202									
CASR	846	broad.mit.edu	37	3	121980624	121980624	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:121980624G>C	uc003eev.3	+	4	1114	c.742G>C	c.(742-744)GAT>CAT	p.D248H	CASR_uc003eew.3_Missense_Mutation_p.D248H	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	248	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCAGTACTCTGATGAGGAAGA	0.502		NaN											0	0	0	0.048971	0	60	157									
PLXND1	23129	broad.mit.edu	37	3	129303367	129303367	+	Silent	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:129303367G>C	uc003emx.2	-	6	1990	c.1890C>G	c.(1888-1890)CTC>CTG	p.L630L		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	630	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CCATGCCACTGAGGCTGGGCA	0.637		NaN											0	0	0	0.074837	0	38	54									
PAQR9	344838	broad.mit.edu	37	3	142681210	142681210	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:142681210G>A	uc003evg.2	-	1	969	c.969C>T	c.(967-969)TAC>TAT	p.Y323Y	PAQR9_uc003evf.1_RNA	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	323	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						ACACCTGGTCGTAGATGCTGA	0.597		NaN											0	0	0	0.069234	0	11	108									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.076483	0	22	9									
GABRA4	2557	broad.mit.edu	37	4	46967082	46967082	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:46967082G>C	uc003gxg.2	-	8	1178	c.1039C>G	c.(1039-1041)CAA>GAA	p.Q347E		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	347	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTTCCATTTGAATATTGGTG	0.478		NaN											0	0	0	0.099896	0	26	68									
AASDH	132949	broad.mit.edu	37	4	57220365	57220365	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:57220365C>G	uc003hbn.2	-	8	1376	c.1223G>C	c.(1222-1224)AGA>ACA	p.R408T	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.R255T|AASDH_uc003hbo.2_Missense_Mutation_p.R308T|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Missense_Mutation_p.R408T|AASDH_uc003hbp.2_Missense_Mutation_p.R408T	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	408					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				AAAACACACTCTGTTTCTGCC	0.373		NaN											0	0	0	0.09319	0	12	51									
RASA1	5921	broad.mit.edu	37	5	86672272	86672272	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr5:86672272C>G	uc003kiw.2	+	16	2192	c.2074C>G	c.(2074-2076)CTC>GTC	p.L692V	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.L515V|RASA1_uc011ctv.1_Missense_Mutation_p.L525V|RASA1_uc011ctw.1_Missense_Mutation_p.L526V|RASA1_uc010jaw.2_Missense_Mutation_p.L514V	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	692					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ATGGTTTCTGCTCAGCTCCCA	0.423		NaN											0	0	0	0.080935	0	12	17									
PCDHB1	29930	broad.mit.edu	37	5	140432013	140432013	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr5:140432013C>T	uc003lik.1	+	1	1035	c.958C>T	c.(958-960)CAA>TAA	p.Q320*		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	320	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTGACATTCAAGCTACAGA	0.473		NaN											0	0	0	0.048971	0	52	42									
MSH5	4439	broad.mit.edu	37	6	31712335	31712335	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:31712335G>A	uc003nwv.1	+	8	739	c.660G>A	c.(658-660)GTG>GTA	p.V220V	MSH5_uc003nwt.1_Silent_p.V237V|MSH5_uc003nwu.1_Silent_p.V220V|MSH5_uc003nww.1_Silent_p.V220V|MSH5_uc003nwx.1_Silent_p.V237V|MSH5_uc011dof.1_5'UTR	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	220					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CTCATCTGGTGAACATAGATC	0.463		NaN						Direct_reversal_of_damage|MMR					0	0	0	0.059317	0	33	49									
EEF1A1	1915	broad.mit.edu	37	6	74229729	74229729	+	Silent	SNP	A	A	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:74229729A>G	uc003phi.2	-	1	58	c.21T>C	c.(19-21)CAT>CAC	p.H7H	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Silent_p.H7H|EEF1A1_uc003phf.2_Silent_p.H7H|EEF1A1_uc003phg.2_Silent_p.H7H|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Silent_p.H7H|EEF1A1_uc003phk.2_Silent_p.H7H|EEF1A1_uc003phl.2_Silent_p.H7H|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	7						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						CAATGTTGATATGAGTCTTTT	0.423		NaN											0	0	0	0.034045	0	31	52									
ZNF292	23036	broad.mit.edu	37	6	87967337	87967337	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:87967337C>T	uc003plm.3	+	8	4031	c.3990C>T	c.(3988-3990)TTC>TTT	p.F1330F		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CAAATAACTTCAGTAGCACCA	0.428		NaN											0	0	0	0.014758	0	5	12									
TIAM2	26230	broad.mit.edu	37	6	155566797	155566797	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:155566797C>T	uc003qqb.2	+	21	4857	c.3584C>T	c.(3583-3585)GCG>GTG	p.A1195V	TIAM2_uc003qqe.2_Missense_Mutation_p.A1195V|TIAM2_uc010kjj.2_Missense_Mutation_p.A728V|TIAM2_uc003qqf.2_Missense_Mutation_p.A571V|TIAM2_uc011efl.1_Missense_Mutation_p.A531V|TIAM2_uc003qqg.2_Missense_Mutation_p.A507V|TIAM2_uc003qqh.2_Missense_Mutation_p.A120V	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1195	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTTTATTACGCGGACCACTTT	0.403		NaN											0	0	0	0.048971	0	86	217									
SNX9	51429	broad.mit.edu	37	6	158330750	158330750	+	Silent	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:158330750G>C	uc003qqv.1	+	8	932	c.759G>C	c.(757-759)GTG>GTC	p.V253V		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	253	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		TTGACTGTGTGGTAGCAGATC	0.393		NaN											0	0	0	0.041601	0	32	77									
POLD2	5425	broad.mit.edu	37	7	44157603	44157603	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:44157603A>T	uc010kxz.2	-	4	931	c.281T>A	c.(280-282)GTG>GAG	p.V94E	POLD2_uc003tke.3_Missense_Mutation_p.V94E|POLD2_uc010kya.2_Missense_Mutation_p.V94E|POLD2_uc003tkf.3_Missense_Mutation_p.V94E	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	94					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						CAGAGTGCCCACCACACAGCA	0.622		NaN											0	0	0	0.064281	0	37	59									
AUTS2	26053	broad.mit.edu	37	7	70255358	70255358	+	Silent	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:70255358C>T	uc003tvw.3	+	19	3899	c.3156C>T	c.(3154-3156)ATC>ATT	p.I1052I	AUTS2_uc003tvx.3_Silent_p.I1028I|AUTS2_uc011keg.1_Silent_p.I504I	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1052										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TCATGGGCATCAGCCCCCTCC	0.622		NaN											0	0	0	0.02938	0	6	23									
HEPACAM2	253012	broad.mit.edu	37	7	92848628	92848628	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:92848628T>A	uc003umm.2	-	2	239	c.216A>T	c.(214-216)AGA>AGT	p.R72S	HEPACAM2_uc003uml.2_Missense_Mutation_p.R60S|HEPACAM2_uc010lff.2_Missense_Mutation_p.R60S|HEPACAM2_uc011khy.1_Missense_Mutation_p.R95S	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	72	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TTGTGTGGGGTCTCTCAAATA	0.498		NaN											0	0	0	0.041601	0	32	60									
ASB4	51666	broad.mit.edu	37	7	95165854	95165854	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:95165854G>A	uc011kij.1	+	4	1084	c.1084G>A	c.(1084-1086)GAC>AAC	p.D362N		NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	362					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CCCCGATGATGACTTGGAGGT	0.388		NaN											0	0	0	0.105934	0	13	37									
LMTK2	22853	broad.mit.edu	37	7	97821587	97821587	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:97821587G>C	uc003upd.1	+	11	2103	c.1810G>C	c.(1810-1812)GAG>CAG	p.E604Q		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	604					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CAGTACAGATGAGGACTTCTT	0.517		NaN											0	0	0	0.043863	0	19	39									
MLL5	55904	broad.mit.edu	37	7	104730618	104730618	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104730618G>A	uc003vcm.2	+	14	2055	c.1521G>A	c.(1519-1521)CAG>CAA	p.Q507Q	MLL5_uc010lja.1_Silent_p.Q361Q|MLL5_uc010ljb.1_Silent_p.Q507Q|MLL5_uc003vcl.2_Silent_p.Q507Q|MLL5_uc010ljc.2_Silent_p.Q507Q|MLL5_uc003vco.1_RNA|MLL5_uc010ljd.1_3'UTR	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	507					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CACAAAATCAGAATATTACTT	0.328		NaN											0	0	0	0.034045	0	30	65									
MLL5	55904	broad.mit.edu	37	7	104731737	104731737	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104731737G>A	uc003vcm.2	+	15	2232	c.1698G>A	c.(1696-1698)CAG>CAA	p.Q566Q	MLL5_uc003vcl.2_Silent_p.Q566Q|MLL5_uc010ljc.2_Silent_p.Q566Q	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	566	Potential.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CAGAGGAGCAGATTGCAGAAA	0.378		NaN											0	0	0	0.058154	0	5	28									
MLL5	55904	broad.mit.edu	37	7	104731744	104731744	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104731744G>A	uc003vcm.2	+	15	2239	c.1705G>A	c.(1705-1707)GAA>AAA	p.E569K	MLL5_uc003vcl.2_Missense_Mutation_p.E569K|MLL5_uc010ljc.2_Missense_Mutation_p.E569K	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	569	Potential.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCAGATTGCAGAAAGGAAAAG	0.383		NaN											0	0	0	0.058154	0	4	27									
MLL5	55904	broad.mit.edu	37	7	104731755	104731755	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104731755G>A	uc003vcm.2	+	15	2250	c.1716G>A	c.(1714-1716)AGG>AGA	p.R572R	MLL5_uc003vcl.2_Silent_p.R572R|MLL5_uc010ljc.2_Silent_p.R572R	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	572	Potential.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AAAGGAAAAGGAAGATGGTAA	0.373		NaN											0	0	0	0.038147	0	4	23									
OR6V1	346517	broad.mit.edu	37	7	142750161	142750161	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:142750161C>A	uc011ksv.1	+	1	724	c.724C>A	c.(724-726)CAC>AAC	p.H242N		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TTGCGGGTCTCACCTCACACT	0.552		NaN											1	0	1.07234e-20	0.048971	1.15178e-20	50	120									
UBR5	51366	broad.mit.edu	37	8	103357737	103357737	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr8:103357737G>C	uc003ykr.1	-	8	806	c.773C>G	c.(772-774)TCT>TGT	p.S258C	UBR5_uc003yks.1_Missense_Mutation_p.S258C	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	258				S -> Y (in Ref. 2; AAF88143).	cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGGGTGGGCAGAATGAATGTC	0.413		NaN											0	0	0	0.080935	0	10	25									
UBR5	51366	broad.mit.edu	37	8	103357753	103357753	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr8:103357753C>G	uc003ykr.1	-	8	790	c.757G>C	c.(757-759)GAT>CAT	p.D253H	UBR5_uc003yks.1_Missense_Mutation_p.D253H	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	253					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATGTCGGCATCAAGGAGAGAC	0.403		NaN											0	0	0	0.028581	0	13	25									
CPSF1	29894	broad.mit.edu	37	8	145624217	145624217	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr8:145624217G>A	uc003zcj.2	-	17	1665	c.1590C>T	c.(1588-1590)CCC>CCT	p.P530P		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	530					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CATAGCAGCCGGGAAGCTCAA	0.637		NaN											0	0	0	0.038147	0	6	159									
BSPRY	54836	broad.mit.edu	37	9	116132396	116132396	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:116132396G>C	uc004bhg.3	+	6	1231	c.1183G>C	c.(1183-1185)GAT>CAT	p.D395H	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	395	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						TGCTGTGGCCGATCAGACCAT	0.592		NaN											0	0	0	0.104719	0	39	30									
COL27A1	85301	broad.mit.edu	37	9	116999271	116999271	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:116999271G>A	uc011lxl.1	+	18	2630	c.2630G>A	c.(2629-2631)GGG>GAG	p.G877E	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	877	Collagen-like 5.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GGGAGCCAGGGGTTGCCAGGG	0.622		NaN											0	0	0	0.09319	0	12	10									
SPTAN1	6709	broad.mit.edu	37	9	131370245	131370245	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131370245G>A	uc004bvl.3	+	33	4374	c.4261G>A	c.(4261-4263)GAT>AAT	p.D1421N	SPTAN1_uc004bvm.3_Missense_Mutation_p.D1421N|SPTAN1_uc004bvn.3_Missense_Mutation_p.D1401N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1421	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCAGAAACTTGATATTCTTGA	0.547		NaN											0	0	0	0.034045	0	29	18									
SPTAN1	6709	broad.mit.edu	37	9	131370275	131370275	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131370275G>C	uc004bvl.3	+	33	4404	c.4291G>C	c.(4291-4293)GAG>CAG	p.E1431Q	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1431Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1411Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1431	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGCAGACCTGGAGAAGGCCTG	0.532		NaN											0	0	0	0.034045	0	30	28									
SPTAN1	6709	broad.mit.edu	37	9	131370487	131370487	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131370487G>A	uc004bvl.3	+	34	4536	c.4423G>A	c.(4423-4425)GAC>AAC	p.D1475N	SPTAN1_uc004bvm.3_Missense_Mutation_p.D1475N|SPTAN1_uc004bvn.3_Missense_Mutation_p.D1455N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1475	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGACAAAGGAGACTCACTGGA	0.522		NaN											0	0	0	0.048971	0	82	62									
SPTAN1	6709	broad.mit.edu	37	9	131371219	131371219	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371219G>A	uc004bvl.3	+	35	4671	c.4558G>A	c.(4558-4560)GGA>AGA	p.G1520R	SPTAN1_uc004bvm.3_Missense_Mutation_p.G1520R|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1500R	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1520	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTATGCCAAGGGAGACATTTC	0.552		NaN											0	0	0	0.048971	0	46	92									
SPTAN1	6709	broad.mit.edu	37	9	131371243	131371243	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371243G>A	uc004bvl.3	+	35	4695	c.4582G>A	c.(4582-4584)GAG>AAG	p.E1528K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1528K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1508K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1528	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCGGCGCAATGAGGTCTTGGA	0.572		NaN											0	0	0	0.069456	0	37	64									
SPTAN1	6709	broad.mit.edu	37	9	131371429	131371429	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371429G>A	uc004bvl.3	+	36	4737	c.4624G>A	c.(4624-4626)GAG>AAG	p.E1542K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1542K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1522K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1542	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCAGATGATTGAGAAAAGGTC	0.473		NaN											0	0	0	0.037714	0	30	37									
SPTAN1	6709	broad.mit.edu	37	9	131371495	131371495	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371495G>A	uc004bvl.3	+	36	4803	c.4690G>A	c.(4690-4692)GAG>AAG	p.E1564K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1564K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1544K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1564	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGATGAGATTGAGGCTTGGAT	0.478		NaN											0	0	0	0.037714	0	28	21									
SPTAN1	6709	broad.mit.edu	37	9	131374105	131374105	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131374105G>A	uc004bvl.3	+	37	4984	c.4871G>A	c.(4870-4872)GGC>GAC	p.G1624D	SPTAN1_uc004bvm.3_Missense_Mutation_p.G1629D|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1604D	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1624	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCCTGTGCCGGCAGTGAGGAT	0.557		NaN											0	0	0	0.055883	0	14	21									
SPTAN1	6709	broad.mit.edu	37	9	131374110	131374110	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131374110G>A	uc004bvl.3	+	37	4989	c.4876G>A	c.(4876-4878)GAG>AAG	p.E1626K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1631K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1606K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1626	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGCCGGCAGTGAGGATGCTGT	0.557		NaN											0	0	0	0.043863	0	13	19									
SPTAN1	6709	broad.mit.edu	37	9	131377919	131377919	+	Silent	SNP	G	G	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131377919G>A	uc004bvl.3	+	40	5255	c.5142G>A	c.(5140-5142)CTG>CTA	p.L1714L	SPTAN1_uc004bvm.3_Silent_p.L1719L|SPTAN1_uc004bvn.3_Silent_p.L1694L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1714	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGGATCGCCTGAAGGACCTGA	0.542		NaN											0	0	0	0.038395	0	16	23									
SPTAN1	6709	broad.mit.edu	37	9	131378027	131378027	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131378027G>C	uc004bvl.3	+	40	5363	c.5250G>C	c.(5248-5250)AAG>AAC	p.K1750N	SPTAN1_uc004bvm.3_Missense_Mutation_p.K1755N|SPTAN1_uc004bvn.3_Missense_Mutation_p.K1730N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1750	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGAAGATCAAGAGCATGGCGG	0.567		NaN											0	0	0	0.069288	0	24	30									
SPTAN1	6709	broad.mit.edu	37	9	131378038	131378038	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131378038C>T	uc004bvl.3	+	40	5374	c.5261C>T	c.(5260-5262)GCC>GTC	p.A1754V	SPTAN1_uc004bvm.3_Missense_Mutation_p.A1759V|SPTAN1_uc004bvn.3_Missense_Mutation_p.A1734V	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1754	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGCATGGCGGCCTCCCGGCGA	0.572		NaN											0	0	0	0.049695	0	21	27									
LUZP1	7798	broad.mit.edu	37	1	23419916	23419916	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23419916delT	uc001bgk.2	-	4	1223	c.839delA	c.(838-840)AACfs	p.N280fs	LUZP1_uc010odv.1_Frame_Shift_Del_p.N280fs|LUZP1_uc001bgl.2_Frame_Shift_Del_p.N280fs|LUZP1_uc001bgm.1_Frame_Shift_Del_p.N280fs	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	280	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		CTGATTGCGGTTCTTTTCATT	0.393		NaN											NaN	NaN	NaN	NaN	NaN	23	94	---	---							
C15orf52	388115	broad.mit.edu	37	15	40630039	40630040	+	Frame_Shift_Ins	INS	-	-	C			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:40630039_40630040insC	uc001zlh.3	-	6	716_717	c.700_701insG	c.(700-702)GACfs	p.D234fs	C15orf52_uc001zli.1_Frame_Shift_Ins_p.D166fs|C15orf52_uc010ucn.1_Frame_Shift_Ins_p.D24fs	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	234										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTGGGCATAGTCCCAGCCCGCC	0.693		NaN											NaN	NaN	NaN	NaN	NaN	9	32	---	---							
SEMA4B	10509	broad.mit.edu	37	15	90771602	90771602	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:90771602delC	uc002boy.2	+	15	2524	c.2241delC	c.(2239-2241)TTCfs	p.F747fs	SEMA4B_uc002boz.2_Frame_Shift_Del_p.F747fs|SEMA4B_uc010uqd.1_Frame_Shift_Del_p.F585fs|SEMA4B_uc002bpa.2_Frame_Shift_Del_p.F585fs|SEMA4B_uc010bnv.1_Intron	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			TGAAAGTCTTCCTGAAGCAGG	0.612		NaN											NaN	NaN	NaN	NaN	NaN	16	26	---	---							
OTOP1	133060	broad.mit.edu	37	4	4228274	4228282	+	In_Frame_Del	DEL	CCACAGCAG	CCACAGCAG	-	rs111245977		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:4228274_4228282delCCACAGCAG	uc003ghp.1	-	1	340_348	c.310_318delCTGCTGTGG	c.(310-318)CTGCTGTGGdel	p.LLW104del		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	104_106	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCACAGCATCCACAGCAGCTGCAGCAGC	0.727		NaN											NaN	NaN	NaN	NaN	NaN	8	23	---	---							
EEF1A1	1915	broad.mit.edu	37	6	74229695	74229696	+	Frame_Shift_Ins	INS	-	-	CGAATCTA			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:74229695_74229696insCGAATCTA	uc003phi.2	-	1	91_92	c.54_55insTAGATTCG	c.(52-57)TCGGGCfs	p.S18fs	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phf.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phg.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phk.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phl.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	18_19	GTP (By similarity).					cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						GTGGACTTGCCCGAATCTACGT	0.416		NaN											NaN	NaN	NaN	NaN	NaN	25	76	---	---							
SPTAN1	6709	broad.mit.edu	37	9	131371153	131371154	+	Frame_Shift_Ins	INS	-	-	A			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371153_131371154insA	uc004bvl.3	+	35	4605_4606	c.4492_4493insA	c.(4492-4494)GAAfs	p.E1498fs	SPTAN1_uc004bvm.3_Frame_Shift_Ins_p.E1498fs|SPTAN1_uc004bvn.3_Frame_Shift_Ins_p.E1478fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1498	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTTCTGACAGGAAGAGAAGATT	0.54		NaN											NaN	NaN	NaN	NaN	NaN	50	128	---	---							
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	uc010njt.2	-	1						NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.584		NaN								HNSCC(48;0.14)			NaN	NaN	NaN	NaN	NaN	4	7	---	---