Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
MEGF6	1953	broad.mit.edu	37	1	3407103	3407103	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:3407103C>T	uc001akl.2	-	37	4842	c.4615G>A	c.(4615-4617)GCG>ACG	p.A1539T	MEGF6_uc001akk.2_Missense_Mutation_p.A1227T	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1539						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TAGTGCCTCGCTGGTCCACCG	0.672		NaN											0	0	0	0.740014	0	30	58									
GPR157	80045	broad.mit.edu	37	1	9164616	9164616	+	Silent	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:9164616G>C	uc001apq.1	-	4	1013	c.870C>G	c.(868-870)CTC>CTG	p.L290L	GPR157_uc010oad.1_Silent_p.L225L	NM_024980	NP_079256	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	290	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		AGAGAGAGAAGAGCCGAGTTC	0.612		NaN											0	0	0	0.740014	0	19	64									
PRAMEF18	391003	broad.mit.edu	37	1	13475073	13475073	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:13475073C>T	uc009vnu.1	-	3	1103	c.1056G>A	c.(1054-1056)CAG>CAA	p.Q352Q		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	352											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGAAGAGGGTCTGAAGAGTGG	0.547		NaN											0	0	0	0.870114	0	145	223									
LPHN2	23266	broad.mit.edu	37	1	82456786	82456786	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:82456786G>C	uc001dit.3	+	21	4350	c.4169G>C	c.(4168-4170)GGA>GCA	p.G1390A	LPHN2_uc001dis.2_Missense_Mutation_p.G370A|LPHN2_uc001diu.2_Missense_Mutation_p.G1390A|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.G1017A	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1446	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		attccagAAGGAGATGTTAGA	0.199		NaN											0	0	0	0.335167	0	10	9									
GBP6	163351	broad.mit.edu	37	1	89849217	89849217	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:89849217G>C	uc001dnf.2	+	9	1646	c.1372G>C	c.(1372-1374)GAG>CAG	p.E458Q	GBP6_uc010ost.1_Missense_Mutation_p.E328Q	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	458							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATAGGCAAAAGAGGTCTTCCA	0.408		NaN											0	0	0	0.667858	0	23	24									
OLFM3	118427	broad.mit.edu	37	1	102302527	102302527	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:102302527C>T	uc001duf.2	-	2	255	c.184G>A	c.(184-186)GAT>AAT	p.D62N	OLFM3_uc001dug.2_Missense_Mutation_p.D42N|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_5'UTR|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	62						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CACCGCCCATCAGGATCCTGA	0.488		NaN											0	0	0	0.796494	0	36	39									
PDE4DIP	9659	broad.mit.edu	37	1	144864168	144864168	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:144864168T>G	uc001elw.3	-	36	6218	c.5927A>C	c.(5926-5928)GAG>GCG	p.E1976A	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E1870A|PDE4DIP_uc001elv.3_Missense_Mutation_p.E983A|PDE4DIP_uc001ema.2_Missense_Mutation_p.E163A	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1976	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AAGACGTTCCTCCCTGAAATG	0.448		NaN	T	PDGFRB	MPD								0	0	0	0.870114	0	106	453									
PDE4DIP	9659	broad.mit.edu	37	1	144864203	144864203	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:144864203C>G	uc001elw.3	-	36	6183	c.5892G>C	c.(5890-5892)TTG>TTC	p.L1964F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.L1858F|PDE4DIP_uc001elv.3_Missense_Mutation_p.L971F|PDE4DIP_uc001ema.2_Missense_Mutation_p.L151F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1964	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTTCTCCCTCAAGTCTTCCA	0.547		NaN	T	PDGFRB	MPD								0	0	0	0.870114	0	78	444									
DENND4B	9909	broad.mit.edu	37	1	153907303	153907303	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:153907303C>T	uc001fdd.1	-	18	3107	c.2706G>A	c.(2704-2706)CAG>CAA	p.Q902Q	uc001fdc.1_RNA	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	902	Gln-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgttgctgct	0.468		NaN											0	0	0	0.248553	0	5	69									
TNR	7143	broad.mit.edu	37	1	175324643	175324643	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:175324643C>T	uc001gkp.1	-	15	3326	c.3245G>A	c.(3244-3246)CGC>CAC	p.R1082H	TNR_uc009wwu.1_Missense_Mutation_p.R1082H	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1082	Fibronectin type-III 9.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCTCACCTTGCGGCTTCCATC	0.512		NaN											0	0	0	0.804634	0	35	66									
KCNT2	343450	broad.mit.edu	37	1	196434452	196434452	+	Silent	SNP	T	T	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:196434452T>A	uc001gtd.1	-	8	669	c.609A>T	c.(607-609)ATA>ATT	p.I203I	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.I203I|KCNT2_uc001gtf.1_Silent_p.I203I|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.I203I|KCNT2_uc009wyv.1_Silent_p.I178I	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	203	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GTAATGTAGATATTAAAATCA	0.269		NaN											0	0	0	0.217242	0	5	68									
FAM171A1	221061	broad.mit.edu	37	10	15326047	15326047	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:15326047G>A	uc001iob.2	-	2	162	c.155C>T	c.(154-156)GCG>GTG	p.A52V		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	52	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						CTCGATGAGCGCATCTGCTAC	0.552		NaN											0	0	0	0.779181	0	33	45									
SVIL	6840	broad.mit.edu	37	10	29752434	29752434	+	Silent	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:29752434G>C	uc001iut.1	-	35	7017	c.6264C>G	c.(6262-6264)CTC>CTG	p.L2088L	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.L1002L|SVIL_uc001iuu.1_Silent_p.L1662L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2088	Gelsolin-like 5.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGCAGTACTGGAGCACAGTCT	0.617		NaN											0	0	0	0.435327	0	12	43									
CTNNA3	29119	broad.mit.edu	37	10	68381455	68381455	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:68381455G>A	uc009xpn.1	-	10	1492	c.1369C>T	c.(1369-1371)CCA>TCA	p.P457S	CTNNA3_uc001jmw.2_Missense_Mutation_p.P457S|CTNNA3_uc001jmx.3_Missense_Mutation_p.P457S	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	457					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CATACCTGTGGACACAAGGTT	0.279		NaN											0	0	0	0.38729	0	11	25									
PBLD	64081	broad.mit.edu	37	10	70048339	70048339	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:70048339G>C	uc001jns.1	-	8	795	c.592C>G	c.(592-594)CTT>GTT	p.L198V	PBLD_uc001jnr.1_Missense_Mutation_p.L165V|PBLD_uc001jnt.1_Missense_Mutation_p.L198V|PBLD_uc001jnu.1_Missense_Mutation_p.L198V|PBLD_uc001jnv.1_3'UTR	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	198					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TTAAGGGTAAGAATAAGCCCT	0.468		NaN											0	0	0	0.870114	0	58	61									
DNA2	1763	broad.mit.edu	37	10	70190242	70190242	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:70190242G>A	uc001jof.2	-	14	2417	c.2417C>T	c.(2416-2418)TCA>TTA	p.S806L	DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	720					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						AATGGACTTTGATCTGCAAAT	0.348		NaN											0	0	0	0.27861	0	7	13									
TLL2	7093	broad.mit.edu	37	10	98155634	98155634	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:98155634C>G	uc001kml.1	-	12	1754	c.1528G>C	c.(1528-1530)GAG>CAG	p.E510Q	TLL2_uc009xvf.1_Missense_Mutation_p.E488Q	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	510	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCACTCACCTCAAAAGCTTGG	0.478		NaN									OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.859065	0	42	61									
SFRP5	6425	broad.mit.edu	37	10	99527601	99527601	+	Silent	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:99527601G>T	uc001kor.3	-	3	790	c.624C>A	c.(622-624)ATC>ATA	p.I208I		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	208	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		TGATCTCCTTGATGCGCATTT	0.542		NaN											1	0	2.96211e-45	0.870114	3.45253e-45	107	228									
SORCS1	114815	broad.mit.edu	37	10	108439408	108439408	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:108439408T>C	uc001kym.2	-	11	1653	c.1645A>G	c.(1645-1647)AGC>GGC	p.S549G	SORCS1_uc001kyl.2_Missense_Mutation_p.S549G|SORCS1_uc009xxs.2_Missense_Mutation_p.S549G|SORCS1_uc001kyn.1_Missense_Mutation_p.S549G|SORCS1_uc001kyo.2_Missense_Mutation_p.S549G	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	549	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACTATGATGCTTGGAGCTGTG	0.413		NaN											0	0	0	0.539581	0	15	17									
MRGPRE	116534	broad.mit.edu	37	11	3249613	3249613	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:3249613C>T	uc001lxq.3	-	2	724	c.414G>A	c.(412-414)CTG>CTA	p.L138L		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	138	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACAGGTGGTCAGGTGGCGTG	0.706		NaN											0	0	0	0.479597	0	13	18									
OR51S1	119692	broad.mit.edu	37	11	4870194	4870194	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:4870194A>T	uc010qyo.1	-	1	245	c.245T>A	c.(244-246)GTC>GAC	p.V82D		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	82	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGGGCAGTGACCAATCCAAT	0.547		NaN											0	0	0	0.608945	0	21	65									
IMMP1L	196294	broad.mit.edu	37	11	31455050	31455050	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:31455050C>A	uc001msy.1	-	6	585	c.389G>T	c.(388-390)GGA>GTA	p.G130V	IMMP1L_uc001msz.1_Missense_Mutation_p.G130V	NM_144981	NP_659418	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane	130					proteolysis	mitochondrial inner membrane	serine-type peptidase activity				0	Lung SC(675;0.225)					TGGAATAGGTCCATAGCACCT	0.368		NaN											1	0	7.04047e-22	0.812448	7.79323e-22	36	56									
POLA2	23649	broad.mit.edu	37	11	65046238	65046238	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:65046238C>T	uc001odj.2	+	6	841	c.499C>T	c.(499-501)CGA>TGA	p.R167*	POLA2_uc009yqf.1_Nonsense_Mutation_p.R167*|POLA2_uc010rod.1_5'UTR|POLA2_uc001odk.2_5'Flank	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	167					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	ACGAAGTAACCGAGGAGAAGT	0.453		NaN											0	0	0	0.870114	0	66	169									
PCF11	51585	broad.mit.edu	37	11	82877720	82877720	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:82877720C>T	uc001ozx.3	+	5	2126	c.1781C>T	c.(1780-1782)GCC>GTC	p.A594V	PCF11_uc010rsu.1_Missense_Mutation_p.A594V	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	594					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TCCAAGTCTGCCAAAAGATGG	0.358		NaN											0	0	0	0.840704	0	43	78									
BACE1	23621	broad.mit.edu	37	11	117164662	117164662	+	Silent	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:117164662G>C	uc001pqz.2	-	4	1091	c.630C>G	c.(628-630)CTC>CTG	p.L210L	BACE1_uc001pqw.2_Intron|BACE1_uc001pqx.2_Intron|BACE1_uc001pqy.2_Silent_p.L166L|BACE1_uc001pra.1_3'UTR|BACE1_uc010rxg.1_Intron|BACE1_uc010rxh.1_Silent_p.L110L|BACE1_uc009yzo.1_5'Flank	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	210	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		GCAGGGAGAAGAGGTTGGGAA	0.567		NaN											0	0	0	0.870114	0	57	73									
TECTA	7007	broad.mit.edu	37	11	121028601	121028601	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:121028601C>T	uc010rzo.1	+	13	4357	c.4357C>T	c.(4357-4359)CGT>TGT	p.R1453C		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1453					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCGCTGTTTCCGTCGCAACGT	0.602		NaN											0	0	0	0.361761	0	9	177									
TEAD4	7004	broad.mit.edu	37	12	3128321	3128321	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:3128321C>T	uc010sej.1	+	8	842	c.565C>T	c.(565-567)CCG>TCG	p.P189S	TEAD4_uc010sek.1_Missense_Mutation_p.P146S|TEAD4_uc001qln.2_Missense_Mutation_p.P61S	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	190					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			TGTCCAGCCTCCGCTGCCTCT	0.682		NaN											0	0	0	0.870114	0	67	91									
TAS2R13	50838	broad.mit.edu	37	12	11061864	11061864	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:11061864C>G	uc001qzg.1	-	1	298	c.34G>C	c.(34-36)GTA>CTA	p.V12L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	12	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						GCAATTATTACAAGAGTGAAG	0.388		NaN											0	0	0	0.457914	0	12	27									
ANP32D	23519	broad.mit.edu	37	12	48866717	48866717	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:48866717C>T	uc010slt.1	+	1	270	c.270C>T	c.(268-270)CTC>CTT	p.L90L		NM_012404	NP_036536	O95626	AN32D_HUMAN	acidic nuclear phosphoprotein 32D	90	LRR 4.									ovary(1)|central_nervous_system(1)	2						GTCCAAACCTCATACATCTAA	0.398		NaN											0	0	0	0.796494	0	35	53									
MLL2	8085	broad.mit.edu	37	12	49425078	49425078	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:49425078C>G	uc001rta.3	-	39	13410	c.13410G>C	c.(13408-13410)AAG>AAC	p.K4470N		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4470					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTTGCACATTCTTTGCCCGGA	0.617		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.870114	0	92	135									
MLL2	8085	broad.mit.edu	37	12	49427906	49427906	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:49427906C>A	uc001rta.3	-	38	10684	c.10684G>T	c.(10684-10686)GAG>TAG	p.E3562*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3562	Potential.|Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGAGCTTCTCAGCATCAGCT	0.547		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	3.4887e-51	0.870114	4.12088e-51	77	113									
HOXC11	3227	broad.mit.edu	37	12	54367330	54367330	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:54367330G>A	uc001sem.2	+	1	421	c.305G>A	c.(304-306)CGG>CAG	p.R102Q		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	102					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTATGCACCGGGAGTGCCTG	0.672		NaN	T	NUP98	AML								0	0	0	0.870114	0	205	294									
SMARCC2	6601	broad.mit.edu	37	12	56567574	56567574	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:56567574C>T	uc001skb.2	-	17	1662	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	SMARCC2_uc001skd.2_Missense_Mutation_p.R519Q|SMARCC2_uc001ska.2_Missense_Mutation_p.R519Q|SMARCC2_uc001skc.2_Missense_Mutation_p.R519Q|SMARCC2_uc010sqf.1_Missense_Mutation_p.R408Q	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	519	SWIRM.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGGGTTGGTCGACTCTCAGC	0.577		NaN											0	0	0	0.870114	0	141	233									
SYT1	6857	broad.mit.edu	37	12	79611344	79611344	+	Silent	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:79611344C>A	uc001sys.2	+	5	716	c.45C>A	c.(43-45)GTC>GTA	p.V15V	SYT1_uc001syt.2_Silent_p.V15V|SYT1_uc001syu.2_Silent_p.V15V|SYT1_uc001syv.2_Silent_p.V15V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	15	Vesicular (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CCCCGCCTGTCACCACTGTCG	0.517		NaN											1	0	3.08376e-08	0.654019	3.1926e-08	18	25									
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:132547087G>A	uc001ujn.2	+	46	8210	c.8175G>A	c.(8173-8175)CAG>CAA	p.Q2725Q	EP400_uc001ujl.2_Silent_p.Q2724Q|EP400_uc001ujm.2_Silent_p.Q2644Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.289		NaN											0	0	0	0.27861	0	6	66									
P2RX2	22953	broad.mit.edu	37	12	133196152	133196152	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:133196152C>A	uc001ukj.1	+	2	301	c.301C>A	c.(301-303)CCC>ACC	p.P101T	P2RX2_uc001uki.1_Missense_Mutation_p.P101T|P2RX2_uc001ukk.1_Missense_Mutation_p.P101T|P2RX2_uc001ukl.1_Missense_Mutation_p.P101T|P2RX2_uc001ukm.1_Missense_Mutation_p.A78D|P2RX2_uc001ukn.1_Intron|P2RX2_uc009zyt.1_Missense_Mutation_p.P101T|P2RX2_uc001uko.1_Missense_Mutation_p.P101T	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	101	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		GTACGTGAAGCCCCCCGAGGT	0.577		NaN											1	0	3.05275e-18	0.864702	3.25626e-18	46	88									
ZC3H13	23091	broad.mit.edu	37	13	46539484	46539484	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr13:46539484C>T	uc010tfw.1	-	15	4408	c.4402G>A	c.(4402-4404)GAA>AAA	p.E1468K	ZC3H13_uc001vaq.2_Missense_Mutation_p.E53K|ZC3H13_uc001vas.1_Missense_Mutation_p.E1469K	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1468							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCATCTAGTTCGTCATCACTG	0.438		NaN											0	0	0	0.307466	0	9	124									
FOS	2353	broad.mit.edu	37	14	75745827	75745827	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr14:75745827G>A	uc001xrn.2	+	1	346	c.141_splice	c.e1+1	p.Q47_splice	FOS_uc010tva.1_Splice_Site_p.Q47_splice|FOS_uc010asi.2_5'Flank|FOS_uc001xro.2_5'Flank	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene						cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CAACGCGCAGGTAAGGCTGGC	0.692		NaN											0	0	0	0.870114	0	41	62									
SETD3	84193	broad.mit.edu	37	14	99866554	99866554	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr14:99866554C>T	uc001ygc.2	-	12	1390	c.1220G>A	c.(1219-1221)AGA>AAA	p.R407K		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	407					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GGTGAAGATTCTATCAATAGC	0.333		NaN											0	0	0	0.870114	0	54	102									
C15orf2	23742	broad.mit.edu	37	15	24921378	24921378	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:24921378A>C	uc001ywo.2	+	1	838	c.364A>C	c.(364-366)ATG>CTG	p.M122L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	122					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCCCAGCCGCATGTTCACTCT	0.647		NaN											0	0	0	0.870114	0	65	129									
DTWD1	56986	broad.mit.edu	37	15	49926748	49926748	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:49926748C>A	uc001zxq.2	+	5	701	c.424C>A	c.(424-426)CCT>ACT	p.P142T	DTWD1_uc001zxs.2_Missense_Mutation_p.P142T|DTWD1_uc001zxr.2_Missense_Mutation_p.P55T|DTWD1_uc001zxo.2_Missense_Mutation_p.P142T	NM_020234	NP_064619	Q8N5C7	DTWD1_HUMAN	DTW domain containing 1	142											0		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		ACTCATTTTTCCTGGACCTCA	0.308		NaN											1	0	8.16277e-20	0.827153	8.81379e-20	35	51									
SCG3	29106	broad.mit.edu	37	15	51975502	51975502	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:51975502G>C	uc002abh.2	+	4	676	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	90					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		AATTGAGAAAGAAAGACAATC	0.358		NaN											0	0	0	0.870114	0	98	144									
HCN4	10021	broad.mit.edu	37	15	73624589	73624589	+	Silent	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:73624589G>T	uc002avp.2	-	3	2248	c.1254C>A	c.(1252-1254)ATC>ATA	p.I418I		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	418	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGAGGTTCACGATGCGCACCA	0.612		NaN											1	0	1.1794e-34	0.870114	1.3567e-34	70	96									
RPP25	54913	broad.mit.edu	37	15	75248520	75248520	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:75248520G>A	uc002azj.1	-	1	1256	c.405C>T	c.(403-405)CTC>CTT	p.L135L		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	135					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GTAGGATGGCGAGGCCGGGCA	0.697		NaN											0	0	0	0.479597	0	15	19									
CHD2	1106	broad.mit.edu	37	15	93563313	93563313	+	Missense_Mutation	SNP	G	G	T	rs61752830		TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:93563313G>T	uc002bsp.2	+	38	5553	c.4978G>T	c.(4978-4980)GAC>TAC	p.D1660Y	CHD2_uc002bso.1_Missense_Mutation_p.D1660Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1660					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATGGGGAAGCGACAGGCACCA	0.512		NaN											1	0	1.1804e-14	0.667858	1.24401e-14	25	42									
ADAMTS17	170691	broad.mit.edu	37	15	100673517	100673517	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:100673517G>A	uc002bvv.1	-	11	1556	c.1477C>T	c.(1477-1479)CTA>TTA	p.L493L	ADAMTS17_uc002bvx.1_Silent_p.L250L	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	493	Disintegrin.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		gcacacattagatgctGCAGG	0.244		NaN											0	0	0	0.248553	0	6	18									
C16orf91	283951	broad.mit.edu	37	16	1476162	1476162	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:1476162G>T	uc010uvd.1	-	3	461	c.461C>A	c.(460-462)GCT>GAT	p.A154D		NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	127	Cytoplasmic (Potential).					integral to membrane					0						GGACCTGGGAGCACCCACTGT	0.637		NaN											1	0	2.59497e-14	0.834066	2.71854e-14	43	270									
CORO7	79585	broad.mit.edu	37	16	4411441	4411441	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:4411441C>T	uc002cwh.3	-	17	1728	c.1608G>A	c.(1606-1608)ACG>ACA	p.T536T	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Silent_p.T536T|CORO7_uc002cwg.3_Silent_p.T316T|CORO7_uc010uxh.1_Silent_p.T518T|CORO7_uc010uxi.1_Silent_p.T451T|CORO7_uc002cwi.1_Silent_p.T316T|CORO7_uc010uxj.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	536						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TGGGCAGTGCCGTGTCGGGCA	0.687		NaN											0	0	0	0.804634	0	35	95									
SRCAP	10847	broad.mit.edu	37	16	30723437	30723437	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:30723437G>C	uc002dze.1	+	12	2159	c.1774G>C	c.(1774-1776)GAA>CAA	p.E592Q	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E449Q|SRCAP_uc010bzz.1_Missense_Mutation_p.E162Q	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	592					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGCAGCAGCTGAAAGTCTCCA	0.542		NaN											0	0	0	0.847076	0	42	85									
SRCAP	10847	broad.mit.edu	37	16	30724116	30724116	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:30724116G>A	uc002dze.1	+	14	2495	c.2110G>A	c.(2110-2112)GAG>AAG	p.E704K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E561K|SRCAP_uc010bzz.1_Missense_Mutation_p.E274K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	704	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGCCCAGAAAGAGAGGAAGCT	0.463		NaN											0	0	0	0.870114	0	77	125									
SRCAP	10847	broad.mit.edu	37	16	30724634	30724634	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:30724634G>C	uc002dze.1	+	15	2621	c.2236G>C	c.(2236-2238)GAT>CAT	p.D746H	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.D603H|SRCAP_uc010bzz.1_Missense_Mutation_p.D316H	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	746	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TCTCATTCTGGATGAGGCGCA	0.527		NaN											0	0	0	0.870114	0	96	132									
ABCC12	94160	broad.mit.edu	37	16	48177903	48177903	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:48177903C>T	uc002efc.1	-	2	539	c.193G>A	c.(193-195)GTG>ATG	p.V65M	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.V65M|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	65						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TAGCCTTTCACCATCACCGGC	0.547		NaN											0	0	0	0.788014	0	38	65									
CDH15	1013	broad.mit.edu	37	16	89261395	89261395	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:89261395G>A	uc002fmt.2	+	14	2354	c.2277G>A	c.(2275-2277)GAG>GAA	p.E759E		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	759	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		AGGGCGATGAGGACCAGGACT	0.657		NaN											0	0	0	0.706142	0	28	32									
ALOX12B	242	broad.mit.edu	37	17	7976982	7976982	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:7976982G>T	uc002gjy.1	-	13	2009	c.1748C>A	c.(1747-1749)ACA>AAA	p.T583K		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	583	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						TACCTGGCCTGTGTTGACAGC	0.358		NaN								Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.20262e-25	0.769981	2.45355e-25	33	63									
MED24	9862	broad.mit.edu	37	17	38178227	38178227	+	Silent	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:38178227G>T	uc002htt.2	-	23	2917	c.2604C>A	c.(2602-2604)GCC>GCA	p.A868A	MED24_uc010weq.1_5'Flank|MED24_uc002htr.2_5'UTR|MED24_uc010wer.1_Silent_p.A203A|MED24_uc010wes.1_Silent_p.A728A|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Silent_p.A893A|MED24_uc002htu.2_Silent_p.A855A|MED24_uc010cwn.2_Silent_p.A855A|MED24_uc010weu.1_Silent_p.A778A|MED24_uc010wev.1_Silent_p.A818A	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	868					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					AAAGGATGTTGGCATCGTCCT	0.587		NaN											1	0	8.79861e-51	0.870114	1.03237e-50	75	129									
BRCA1	672	broad.mit.edu	37	17	41246211	41246211	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:41246211C>G	uc002icq.2	-	10	1569	c.1337G>C	c.(1336-1338)AGA>ACA	p.R446T	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R375T|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.R399T|BRCA1_uc002ict.2_Missense_Mutation_p.R446T|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.R446T|BRCA1_uc002ide.1_Missense_Mutation_p.R277T|BRCA1_uc010cyy.1_Missense_Mutation_p.R446T|BRCA1_uc010whs.1_Missense_Mutation_p.R446T|BRCA1_uc010cyz.2_Missense_Mutation_p.R399T|BRCA1_uc010cza.2_Missense_Mutation_p.R420T|BRCA1_uc010wht.1_Missense_Mutation_p.R150T	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	446					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGAGTGAACTCTTTCACTTTT	0.378		NaN	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	0.864702	0	47	70									
SCN4A	6329	broad.mit.edu	37	17	62020234	62020234	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:62020234C>T	uc002jds.1	-	23	4317	c.4240G>A	c.(4240-4242)GTT>ATT	p.V1414I		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1414	Helical; Name=S3 of repeat IV; (Potential).|IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TTCCAGCCAACGGTGAAGTAG	0.572		NaN											0	0	0	0.870114	0	63	190									
GRIN2C	2905	broad.mit.edu	37	17	72843023	72843023	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:72843023A>C	uc002jlt.1	-	10	2194	c.2038T>G	c.(2038-2040)TTC>GTC	p.F680V	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.F680V	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	680	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ACCGTGCCGAAGCGGAAAGGT	0.612		NaN											0	0	0	0.870114	0	104	260									
GGA3	23163	broad.mit.edu	37	17	73235616	73235616	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:73235616G>A	uc002jni.1	-	14	1629	c.1620C>T	c.(1618-1620)CTC>CTT	p.L540L	GGA3_uc002jnj.1_Silent_p.L507L|GGA3_uc010wrw.1_Silent_p.L418L|GGA3_uc002jnk.1_Silent_p.L468L|GGA3_uc010wrx.1_Silent_p.L418L|GGA3_uc010wry.1_Silent_p.L468L	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	540	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGGTGGGGATGAGAGGGGAGG	0.667		NaN									OREG0024729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.27861	0	8	24									
SLC25A19	60386	broad.mit.edu	37	17	73269536	73269536	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:73269536C>T	uc002jns.3	-	6	1869	c.959G>A	c.(958-960)CGC>CAC	p.R320H	SLC25A19_uc010dge.2_Missense_Mutation_p.R263H|SLC25A19_uc002jnv.3_Missense_Mutation_p.R320H|SLC25A19_uc002jnu.3_Missense_Mutation_p.R320H|SLC25A19_uc002jnw.3_Missense_Mutation_p.R320H|SLC25A19_uc002jnt.3_Missense_Mutation_p.R320H	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	320						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			CTGCACTCAGCGCTGGCTGGC	0.567		NaN											0	0	0	0.870114	0	46	185									
GAA	2548	broad.mit.edu	37	17	78079575	78079575	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:78079575G>T	uc002jxo.2	+	4	756	c.574G>T	c.(574-576)GAG>TAG	p.E192*	GAA_uc002jxp.2_Nonsense_Mutation_p.E192*|GAA_uc002jxq.2_Nonsense_Mutation_p.E192*	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	192					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	CAGGCGCTACGAGGTGCCCTT	0.602		NaN											1	0	7.47603e-22	0.870114	8.22363e-22	49	193									
ZADH2	284273	broad.mit.edu	37	18	72913894	72913894	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr18:72913894C>A	uc002llx.2	-	2	879	c.611G>T	c.(610-612)TGC>TTC	p.C204F	ZADH2_uc010dqv.2_Missense_Mutation_p.C81F	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	204						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		ATCAGAAGAGCAGGTTCCAAT	0.468		NaN											1	0	1.47391e-114	0.870114	1.75275e-114	267	687									
PLIN5	440503	broad.mit.edu	37	19	4523684	4523684	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:4523684C>T	uc002mas.2	-	8	1301	c.1248G>A	c.(1246-1248)CAG>CAA	p.Q416Q		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	416						lipid particle					0						CCCAGGCTCTCTGCTGGGCCG	0.711		NaN									OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.870114	0	129	177									
LOC55908	55908	broad.mit.edu	37	19	11350372	11350372	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:11350372C>T	uc010dxx.2	+	2	220	c.218C>T	c.(217-219)TCA>TTA	p.S73L	DOCK6_uc010xlq.1_5'Flank|DOCK6_uc002mqs.3_Intron|LOC55908_uc010dxw.2_Intron	NM_018687	NP_061157	Q6UXH0	TD26_HUMAN	hepatocellular carcinoma-associated gene TD26	20						extracellular region					0						CGGCCTGCCTCAGCGGCCCCC	0.642		NaN											0	0	0	0.796494	0	37	53									
LPHN1	22859	broad.mit.edu	37	19	14274115	14274115	+	Silent	SNP	A	A	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:14274115A>C	uc010xnn.1	-	6	809	c.513T>G	c.(511-513)GGT>GGG	p.G171G	LPHN1_uc010xno.1_Silent_p.G166G|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	171	Olfactomedin-like.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						AGATGCGGTCACCCGCCTGCA	0.652		NaN											0	0	0	0.840704	0	11	53									
MLL4	9757	broad.mit.edu	37	19	36223287	36223287	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:36223287C>T	uc010eei.2	+	29	5837	c.5837C>T	c.(5836-5838)TCA>TTA	p.S1946L		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1946					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCCTACCTCAGTCGTCACA	0.677		NaN											0	0	0	0.693898	0	24	29									
ZNF780B	163131	broad.mit.edu	37	19	40541026	40541026	+	Silent	SNP	G	G	A	rs143352640	by1000genomes	TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:40541026G>A	uc002omu.2	-	5	1805	c.1740C>T	c.(1738-1740)ACC>ACT	p.T580T	ZNF780B_uc002omv.2_Silent_p.T432T	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTTTCTTTCCGGTATGAATAC	0.388		NaN											0	0	0	0.796494	0	36	123									
ERF	2077	broad.mit.edu	37	19	42752674	42752674	+	Silent	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:42752674C>A	uc002ote.3	-	4	1748	c.1590G>T	c.(1588-1590)GTG>GTT	p.V530V	ERF_uc002otd.3_Silent_p.V261V	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	530					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				GGTCAGAGCTCACCCGCCTTG	0.711		NaN											1	0	2.68985e-26	0.870114	3.05428e-26	48	72									
ZNF234	10780	broad.mit.edu	37	19	44662014	44662014	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:44662014G>C	uc002oym.2	+	6	2152	c.1845G>C	c.(1843-1845)CAG>CAC	p.Q615H	ZNF234_uc002oyl.3_Missense_Mutation_p.Q615H	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	615	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AACTTCATCAGAGTGTCCACA	0.473		NaN											0	0	0	0.870114	0	55	81									
PNMAL1	55228	broad.mit.edu	37	19	46973800	46973800	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:46973800C>G	uc002peq.3	-	2	799	c.493G>C	c.(493-495)GAT>CAT	p.D165H	PNMAL1_uc002per.3_Missense_Mutation_p.D165H	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	165											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ATCTCGGCATCCATGCAGAAG	0.428		NaN											0	0	0	0.870114	0	121	175									
FAM71E1	112703	broad.mit.edu	37	19	50978631	50978631	+	Silent	SNP	A	A	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:50978631A>G	uc002psh.2	-	3	848	c.490T>C	c.(490-492)TTG>CTG	p.L164L	FAM71E1_uc002psg.2_Silent_p.L148L|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	164										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GCCAGAAGCAATAGGTCCGGG	0.647		NaN											0	0	0	0.457914	0	14	36									
MBOAT7	79143	broad.mit.edu	37	19	54677813	54677813	+	Silent	SNP	A	A	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:54677813A>C	uc002qdq.2	-	9	1610	c.1344T>G	c.(1342-1344)GGT>GGG	p.G448G	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Silent_p.G132G|MBOAT7_uc010yem.1_Silent_p.G430G|MBOAT7_uc002qdr.2_Silent_p.G448G|MBOAT7_uc002qds.2_Silent_p.G375G|MBOAT7_uc010yen.1_Silent_p.G375G	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	448	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGCTGCCCCCACCTAAAGCCA	0.662		NaN											0	0	0	0.479597	0	10	105									
SLC4A1AP	22950	broad.mit.edu	37	2	27898484	27898484	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:27898484G>A	uc002rlk.3	+	6	1713	c.1431G>A	c.(1429-1431)CTG>CTA	p.L477L		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	477						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGACTGGCCTGATTGAGAAGA	0.398		NaN											0	0	0	0.729181	0	30	61									
EFEMP1	2202	broad.mit.edu	37	2	56108800	56108800	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:56108800G>T	uc002rzh.2	-	5	917	c.587C>A	c.(586-588)TCC>TAC	p.S196Y	EFEMP1_uc002rzi.2_Missense_Mutation_p.S196Y|EFEMP1_uc002rzj.2_Missense_Mutation_p.S196Y|EFEMP1_uc010ypc.1_Missense_Mutation_p.S138Y	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	196	EGF-like 2; calcium-binding (Potential).				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACATGCAAAGGATCCCCGTAA	0.507		NaN											1	0	7.76418e-22	0.693898	8.48756e-22	27	48									
ATOH8	84913	broad.mit.edu	37	2	85982034	85982034	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:85982034C>G	uc002sqn.2	+	1	1126	c.722C>G	c.(721-723)ACG>AGG	p.T241R	ATOH8_uc002sqm.3_Missense_Mutation_p.T241R	NM_032827	NP_116216	Q96SQ7	ATOH8_HUMAN	atonal homolog 8	241	Basic motif.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						AGGGAGCGGACGCGGGTGCAC	0.706		NaN											0	0	0	0.870114	0	70	101									
LYG2	254773	broad.mit.edu	37	2	99858848	99858848	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:99858848G>T	uc002szw.1	-	6	731	c.618C>A	c.(616-618)TTC>TTA	p.F206L	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_3'UTR	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	lysozyme G-like 2 precursor	206					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1						GTCTTTTATAGAACTTAGCTC	0.463		NaN											1	0	1.4709e-25	0.870114	1.64891e-25	58	100									
GCC2	9648	broad.mit.edu	37	2	109103046	109103046	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:109103046C>T	uc002tec.2	+	16	4026	c.3872C>T	c.(3871-3873)ACG>ATG	p.T1291M	GCC2_uc002ted.2_Missense_Mutation_p.T1190M	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1291	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						CACCAGCGTACGCTAAGTGCA	0.502		NaN											0	0	0	0.812448	0	40	43									
NFE2L2	4780	broad.mit.edu	37	2	178098953	178098953	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:178098953C>G	uc002ulh.3	-	2	647	c.92G>C	c.(91-93)GGA>GCA	p.G31A	NFE2L2_uc002ulg.3_Missense_Mutation_p.G15A|NFE2L2_uc010zfa.1_Missense_Mutation_p.G15A|NFE2L2_uc002uli.3_Missense_Mutation_p.G15A|NFE2L2_uc010fra.2_Missense_Mutation_p.G15A|NFE2L2_uc010frb.2_Missense_Mutation_p.G15A	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	31					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G31R(1)		central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCGACTTACTCCAAGATCTAT	0.363		NaN	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.608945	0	22	39									
TTN	7273	broad.mit.edu	37	2	179412782	179412782	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179412782C>T	uc010zfg.1	-	288	86091	c.85867G>A	c.(85867-85869)GAT>AAT	p.D28623N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22318N|TTN_uc010zfi.1_Missense_Mutation_p.D22251N|TTN_uc010zfj.1_Missense_Mutation_p.D22126N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29550							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCCAGCATCATTCTTGGCC	0.458		NaN											0	0	0	0.750413	0	34	68									
TTN	7273	broad.mit.edu	37	2	179412881	179412881	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179412881C>G	uc010zfg.1	-	288	85992	c.85768G>C	c.(85768-85770)GAC>CAC	p.D28590H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22285H|TTN_uc010zfi.1_Missense_Mutation_p.D22218H|TTN_uc010zfj.1_Missense_Mutation_p.D22093H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29517							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCCAGAAGTCAGATCCCTTT	0.468		NaN											0	0	0	0.870114	0	88	163									
TTN	7273	broad.mit.edu	37	2	179412928	179412928	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179412928C>T	uc010zfg.1	-	288	85945	c.85721G>A	c.(85720-85722)GGC>GAC	p.G28574D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G22269D|TTN_uc010zfi.1_Missense_Mutation_p.G22202D|TTN_uc010zfj.1_Missense_Mutation_p.G22077D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29501							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCCGGCTGCCTCCATCGTG	0.498		NaN											0	0	0	0.870114	0	74	130									
TTN	7273	broad.mit.edu	37	2	179413248	179413248	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179413248C>T	uc010zfg.1	-	288	85625	c.85401G>A	c.(85399-85401)TTG>TTA	p.L28467L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L22162L|TTN_uc010zfi.1_Silent_p.L22095L|TTN_uc010zfj.1_Silent_p.L21970L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29394							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCCCACATCAATGTAGCAG	0.507		NaN											0	0	0	0.870114	0	99	175									
TTN	7273	broad.mit.edu	37	2	179413427	179413427	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179413427C>T	uc010zfg.1	-	288	85446	c.85222G>A	c.(85222-85224)GAT>AAT	p.D28408N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22103N|TTN_uc010zfi.1_Missense_Mutation_p.D22036N|TTN_uc010zfj.1_Missense_Mutation_p.D21911N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29335							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAAGGAATCTGTTGTATGG	0.448		NaN											0	0	0	0.812448	0	38	72									
SF3B1	23451	broad.mit.edu	37	2	198267484	198267484	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:198267484G>A	uc002uue.2	-	14	1921	c.1873C>T	c.(1873-1875)CGT>TGT	p.R625C		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	625	HEAT 3.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTTGTGTTACGGACATACTCA	0.433		NaN											0	0	0	0.740014	0	30	49									
NIF3L1	60491	broad.mit.edu	37	2	201756682	201756682	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:201756682G>A	uc002uwm.2	+	2	107	c.16G>A	c.(16-18)GTA>ATA	p.V6I	PPIL3_uc002uwh.2_5'Flank|PPIL3_uc002uwi.2_5'Flank|PPIL3_uc002uwj.2_5'Flank|PPIL3_uc002uwk.2_5'Flank|NIF3L1_uc002uwl.2_Intron|NIF3L1_uc002uwn.2_Intron|NIF3L1_uc002uwo.2_Missense_Mutation_p.V6I|NIF3L1_uc002uwp.2_Missense_Mutation_p.V6I|NIF3L1_uc002uwq.2_Missense_Mutation_p.V6I	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	6					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						GTCATCTTGCGTACGCCCAGT	0.438		NaN											0	0	0	0.457914	0	15	24									
USP37	57695	broad.mit.edu	37	2	219360635	219360635	+	Silent	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:219360635C>A	uc002vie.2	-	14	1773	c.1320G>T	c.(1318-1320)CTG>CTT	p.L440L	USP37_uc010fvs.1_Silent_p.L440L|USP37_uc010zkf.1_Silent_p.L440L|USP37_uc002vif.2_Silent_p.L440L|USP37_uc002vig.2_Silent_p.L368L	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	440					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TATCTTCTTTCAGCTGGTCCA	0.338		NaN											1	0	4.62619e-21	0.796494	5.02598e-21	36	63									
ZNF142	7701	broad.mit.edu	37	2	219503085	219503085	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:219503085G>C	uc002vin.2	-	10	5477	c.5041C>G	c.(5041-5043)CCC>GCC	p.P1681A	ZNF142_uc002vil.2_Missense_Mutation_p.P1642A|ZNF142_uc010fvt.2_Missense_Mutation_p.P1518A|ZNF142_uc002vim.2_Missense_Mutation_p.P1518A	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1681					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CCAGTGTGGGGAGCGGCAGGA	0.627		NaN											0	0	0	0.557998	0	14	26									
ZNF142	7701	broad.mit.edu	37	2	219503172	219503172	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:219503172G>A	uc002vin.2	-	10	5390	c.4954C>T	c.(4954-4956)CAG>TAG	p.Q1652*	ZNF142_uc002vil.2_Nonsense_Mutation_p.Q1613*|ZNF142_uc010fvt.2_Nonsense_Mutation_p.Q1489*|ZNF142_uc002vim.2_Nonsense_Mutation_p.Q1489*	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1652					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CCCACACCCTGGTTTGGGTCG	0.622		NaN											0	0	0	0.788014	0	30	66									
INHA	3623	broad.mit.edu	37	2	220439578	220439578	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:220439578C>A	uc002vmk.1	+	2	575	c.431C>A	c.(430-432)GCC>GAC	p.A144D		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	144					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGCACAGCAGCCTCCAATAGC	0.642		NaN											1	0	7.34454e-26	0.870114	8.28615e-26	52	61									
DOCK10	55619	broad.mit.edu	37	2	225653783	225653783	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:225653783C>G	uc010fwz.1	-	48	5655	c.5416G>C	c.(5416-5418)GAG>CAG	p.E1806Q	DOCK10_uc002vob.2_Missense_Mutation_p.E1800Q|DOCK10_uc002voa.2_Missense_Mutation_p.E462Q|DOCK10_uc002voc.2_Missense_Mutation_p.E627Q	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1806	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GGTCTAACCTCATTGTATGGT	0.393		NaN											0	0	0	0.217242	0	6	21									
SP140	11262	broad.mit.edu	37	2	231113635	231113635	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:231113635G>A	uc002vql.2	+	9	1043	c.928G>A	c.(928-930)GAA>AAA	p.E310K	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Missense_Mutation_p.E310K|SP140_uc002vqn.2_Missense_Mutation_p.E257K|SP140_uc002vqm.2_Missense_Mutation_p.E284K|SP140_uc010fxl.2_Missense_Mutation_p.E310K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	310					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTCACTAATGAAGGAGAACC	0.398		NaN											0	0	0	0.740014	0	30	66									
PSMD1	5707	broad.mit.edu	37	2	231947666	231947666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:231947666G>A	uc002vrn.1	+	13	1614	c.1483G>A	c.(1483-1485)GAT>AAT	p.D495N	PSMD1_uc002vrm.1_Missense_Mutation_p.D495N|PSMD1_uc010fxu.1_Missense_Mutation_p.D359N	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	495	PC 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	AGATGTTTATGATTTGCTAAA	0.363		NaN											0	0	0	0.681144	0	25	40									
BAGE2	85319	broad.mit.edu	37	21	11058303	11058303	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr21:11058303G>A	uc002yit.1	-	3	345	c.137C>T	c.(136-138)ACT>ATT	p.T46I	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGCTCCAAAGTGCTTACAAA	0.388		NaN											0	0	0	0.435327	0	10	268									
RNF160	26046	broad.mit.edu	37	21	30365173	30365173	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr21:30365173C>A	uc002ymr.2	-	1	105	c.92G>T	c.(91-93)CGT>CTT	p.R31L		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	Error:Variant_position_missing_in_O94822_after_alignment							ligase activity|zinc ion binding				0						CCGGTTGACACGTCCGGGACA	0.622		NaN											1	0	0.000229342	0.608945	0.000234675	22	44									
TMEM50B	757	broad.mit.edu	37	21	34823156	34823156	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr21:34823156T>C	uc002yrt.1	-	7	624	c.446A>G	c.(445-447)AAA>AGA	p.K149R	TMEM50B_uc002yrs.1_RNA|TMEM50B_uc010gmb.1_RNA	NM_006134	NP_006125	P56557	TM50B_HUMAN	transmembrane protein 50B	149						endoplasmic reticulum|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TCTTCCAAATTTGTAGATCAG	0.348		NaN											0	0	0	0.840704	0	38	45									
CECR6	27439	broad.mit.edu	37	22	17600373	17600373	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:17600373G>A	uc002zmb.2	-	1	1841	c.1645C>T	c.(1645-1647)CAG>TAG	p.Q549*	CECR6_uc002zma.2_Nonsense_Mutation_p.Q194*|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	549											0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GAGCCTCCCTGAGGTGGTGGC	0.687		NaN											0	0	0	0.335167	0	8	20									
GNAZ	2781	broad.mit.edu	37	22	23438310	23438310	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:23438310G>A	uc002zwu.1	+	2	965	c.428G>A	c.(427-429)CGC>CAC	p.R143H	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	143						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TGCTTCAGCCGCTCCAGCGAG	0.657		NaN											0	0	0	0.361761	0	7	140									
MTP18	51537	broad.mit.edu	37	22	30822725	30822725	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:30822725G>A	uc003ahw.1	+	2	236	c.88G>A	c.(88-90)GAG>AAG	p.E30K	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Missense_Mutation_p.E192K|MTP18_uc010gvy.1_Intron|MTP18_uc003ahx.1_Missense_Mutation_p.E30K	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	30					apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						TGAGGTGGGCGAGGCTTTCCG	0.502		NaN									OREG0026460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.870114	0	37	73									
HMGXB4	10042	broad.mit.edu	37	22	35684398	35684398	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:35684398G>A	uc003anl.2	+	9	1810	c.1636G>A	c.(1636-1638)GAG>AAG	p.E546K	HMGXB4_uc003ank.2_Missense_Mutation_p.E437K	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	546					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						GCAGGAAACTGAGGTGAATAC	0.348		NaN											0	0	0	0.681144	0	25	53									
C22orf9	23313	broad.mit.edu	37	22	45601515	45601515	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:45601515G>T	uc003bfx.1	-	4	476	c.410C>A	c.(409-411)TCT>TAT	p.S137Y	C22orf9_uc010gzw.1_5'UTR|C22orf9_uc003bfv.1_Missense_Mutation_p.S146Y|C22orf9_uc003bfw.1_Missense_Mutation_p.S142Y|C22orf9_uc010gzx.2_Missense_Mutation_p.S119Y	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	137							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		GCTCACCTGAGATTTCTTCTT	0.597		NaN											1	0	7.63091e-17	0.834066	8.09061e-17	41	81									
IL5RA	3568	broad.mit.edu	37	3	3144421	3144421	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:3144421G>C	uc011ask.1	-	5	810	c.166C>G	c.(166-168)CAA>GAA	p.Q56E	IL5RA_uc010hbq.2_Missense_Mutation_p.Q56E|IL5RA_uc010hbr.2_Missense_Mutation_p.Q56E|IL5RA_uc010hbs.2_Missense_Mutation_p.Q56E|IL5RA_uc011asl.1_Missense_Mutation_p.Q56E|IL5RA_uc011asm.1_Missense_Mutation_p.Q56E|IL5RA_uc010hbt.2_Missense_Mutation_p.Q56E|IL5RA_uc011asn.1_Missense_Mutation_p.Q56E|IL5RA_uc010hbu.2_Missense_Mutation_p.Q56E	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	56	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		CTTTGCTCTTGATCAGGATTT	0.333		NaN											0	0	0	0.575678	0	20	27									
SCN10A	6336	broad.mit.edu	37	3	38739749	38739749	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:38739749G>A	uc003ciq.2	-	27	4962	c.4962C>T	c.(4960-4962)CTC>CTT	p.L1654L		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1654	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAATCTGGAAGAGGCACAGCA	0.582		NaN											0	0	0	0.870114	0	48	88									
PROS1	5627	broad.mit.edu	37	3	93646147	93646147	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:93646147C>T	uc003drb.3	-	2	522	c.181G>A	c.(181-183)GAA>AAA	p.E61K	PROS1_uc010hoo.2_5'UTR|PROS1_uc003dqz.3_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	61	Gla.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTGCACAGTTCTTCGATGCAT	0.413		NaN											0	0	0	0.740014	0	31	75									
IFT122	55764	broad.mit.edu	37	3	129195584	129195584	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:129195584T>A	uc003emm.2	+	11	1293	c.1087T>A	c.(1087-1089)TAT>AAT	p.Y363N	IFT122_uc003eml.2_Missense_Mutation_p.Y414N|IFT122_uc003emn.2_Missense_Mutation_p.Y304N|IFT122_uc003emo.2_Missense_Mutation_p.Y252N|IFT122_uc003emp.2_Missense_Mutation_p.Y213N|IFT122_uc010htc.2_Missense_Mutation_p.Y355N|IFT122_uc011bky.1_Missense_Mutation_p.Y154N|IFT122_uc003emq.2_Missense_Mutation_p.Y203N|IFT122_uc003emr.2_Missense_Mutation_p.Y154N|IFT122_uc011bla.1_Missense_Mutation_p.Y154N|IFT122_uc011bkx.1_Missense_Mutation_p.Y203N|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	363					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CAAGGACCGCTATGCCTACAG	0.547		NaN											0	0	0	0.870114	0	54	89									
ABCC5	10057	broad.mit.edu	37	3	183689484	183689484	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:183689484G>A	uc003fmg.2	-	11	1793	c.1628C>T	c.(1627-1629)GCA>GTA	p.A543V	ABCC5_uc011bqt.1_Missense_Mutation_p.A71V|ABCC5_uc010hxl.2_Missense_Mutation_p.A543V	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	543						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTTCTGCTCTGCCAGCACCGC	0.597		NaN											0	0	0	0.870114	0	49	100									
C3orf59	151963	broad.mit.edu	37	3	192516318	192516318	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:192516318C>G	uc011bsp.1	-	2	1654	c.1333G>C	c.(1333-1335)GGG>CGG	p.G445R		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	445											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGGGGTCCCCTCCGTCAGAC	0.567		NaN											0	0	0	0.870114	0	69	217									
PPARGC1A	10891	broad.mit.edu	37	4	23814419	23814419	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:23814419C>T	uc003gqs.2	-	10	2090	c.1970G>A	c.(1969-1971)CGA>CAA	p.R657Q	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	657					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CTCAGACTCTCGCTTCTCATA	0.453		NaN											0	0	0	0.870114	0	68	97									
PPARGC1A	10891	broad.mit.edu	37	4	23815883	23815883	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:23815883C>G	uc003gqs.2	-	8	1343	c.1223G>C	c.(1222-1224)AGA>ACA	p.R408T	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	408					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				TTCTAGTTGTCTAGAGTCTTG	0.448		NaN											0	0	0	0.608945	0	22	40									
SDAD1	55153	broad.mit.edu	37	4	76882456	76882456	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:76882456T>C	uc003hje.3	-	15	1306	c.1187A>G	c.(1186-1188)AAT>AGT	p.N396S	SDAD1_uc003hjf.3_Missense_Mutation_p.N299S|SDAD1_uc011cbr.1_Missense_Mutation_p.N359S	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	396				N -> S (in Ref. 1; CAH18368).	protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTTATAGCATTGATTCTAGA	0.368		NaN											0	0	0	0.864702	0	44	59									
GAB1	2549	broad.mit.edu	37	4	144359278	144359278	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:144359278G>A	uc003ije.2	+	4	1079	c.720G>A	c.(718-720)ATG>ATA	p.M240I	GAB1_uc003ijd.2_Missense_Mutation_p.M240I|GAB1_uc011chq.1_Missense_Mutation_p.M137I	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	240					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					AGCAGCAAATGATATACGACT	0.448		NaN											0	0	0	0.654019	0	23	42									
FGG	2266	broad.mit.edu	37	4	155530854	155530854	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:155530854C>T	uc003ioj.2	-	6	735	c.594G>A	c.(592-594)CTG>CTA	p.L198L	FGG_uc003iog.2_Silent_p.L198L|FGG_uc003ioh.2_Silent_p.L206L|FGG_uc010ipx.2_Silent_p.L26L|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Silent_p.L206L	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	198	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GGTTAGCTTTCAGAGGTTTAA	0.393		NaN											0	0	0	0.796494	0	36	76									
KIAA1430	57587	broad.mit.edu	37	4	186111887	186111887	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:186111887G>C	uc003ixf.3	-	2	611	c.464C>G	c.(463-465)TCT>TGT	p.S155C	KIAA1430_uc003ixg.2_Missense_Mutation_p.S155C	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	155											0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		AACGTTAGTAGATGGTTTAGC	0.299		NaN											0	0	0	0.27861	0	7	15									
POLK	51426	broad.mit.edu	37	5	74865308	74865308	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:74865308G>C	uc003kdw.2	+	4	495	c.399G>C	c.(397-399)ATG>ATC	p.M133I	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kdz.2_Missense_Mutation_p.M133I|POLK_uc003kea.2_Missense_Mutation_p.M133I|POLK_uc003keb.2_Missense_Mutation_p.M133I|POLK_uc010izq.2_Missense_Mutation_p.M133I|POLK_uc003kec.2_Missense_Mutation_p.M43I|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.M43I|POLK_uc003kee.2_Missense_Mutation_p.M133I|POLK_uc003kef.2_Missense_Mutation_p.M43I	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	133	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TAGGATCAATGAGTATGCTGG	0.348		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.592651	0	20	33									
PSD2	84249	broad.mit.edu	37	5	139215325	139215325	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:139215325C>G	uc003leu.1	+	9	1582	c.1377C>G	c.(1375-1377)ATC>ATG	p.I459M		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	459	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACTCCATCAAGAATGAAA	0.527		NaN											0	0	0	0.870114	0	287	476									
PCDHB3	56132	broad.mit.edu	37	5	140482583	140482583	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:140482583G>A	uc003lio.2	+	1	2350	c.2350G>A	c.(2350-2352)GAG>AAG	p.E784K	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	784	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGGTTAGCGAGGCAAATCC	0.458		NaN											0	0	0	0.870114	0	105	187									
PCDHGA8	9708	broad.mit.edu	37	5	140774176	140774176	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:140774176G>T	uc003lkd.1	+	1	2694	c.1796G>T	c.(1795-1797)GGC>GTC	p.G599V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.G599V	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	599	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGACTCGGGCCAGAACGCC	0.706		NaN											1	0	3.27435e-08	0.457914	3.37009e-08	14	153									
NSD1	64324	broad.mit.edu	37	5	176709524	176709524	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:176709524G>T	uc003mfr.3	+	19	6089	c.5951G>T	c.(5950-5952)CGA>CTA	p.R1984L	NSD1_uc003mft.3_Missense_Mutation_p.R1715L|NSD1_uc011dfx.1_Missense_Mutation_p.R1632L	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1984	SET.		R -> Q (in SOTOSS; loss of enzyme activity).		negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGCAGAGCTCGAATTCGCTAT	0.373		NaN	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			1	0	4.09166e-32	0.870114	4.67618e-32	76	111									
BRD2	6046	broad.mit.edu	37	6	32944408	32944408	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:32944408C>T	uc003ocn.3	+	7	2596	c.895C>T	c.(895-897)CCA>TCA	p.P299S	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.P299S|BRD2_uc003ocp.3_Missense_Mutation_p.P179S|BRD2_uc010juh.2_Missense_Mutation_p.P299S	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	299					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TCCTGGTTCTCCAGCTAGCCC	0.552		NaN											0	0	0	0.870114	0	82	141									
MAPK14	1432	broad.mit.edu	37	6	36067964	36067964	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:36067964G>A	uc003olp.2	+	9	1164	c.683_splice	c.e9-1	p.H228_splice	MAPK14_uc003olo.2_Intron|MAPK14_uc003olq.2_Intron|MAPK14_uc003olr.2_Intron|MAPK14_uc011dti.1_Intron	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1						activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						AGGCATCTAAGATATTAACCA	0.403		NaN											0	0	0	0.870114	0	63	108									
MRPL14	64928	broad.mit.edu	37	6	44081613	44081613	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:44081613G>A	uc003owp.2	-	3	534	c.405C>T	c.(403-405)TCC>TCT	p.S135S		NM_032111	NP_115487	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14 precursor	135					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			CCAGCACCTTGGAATACTCGC	0.552		NaN											0	0	0	0.859065	0	46	63									
MDN1	23195	broad.mit.edu	37	6	90428326	90428326	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:90428326C>T	uc003pnn.1	-	43	6458	c.6342G>A	c.(6340-6342)TGG>TGA	p.W2114*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2114					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCAGCCTCCTCCAAGGTCGTA	0.473		NaN											0	0	0	0.706142	0	26	53									
TNFAIP3	7128	broad.mit.edu	37	6	138192400	138192400	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:138192400G>C	uc003qhr.2	+	2	102	c.36G>C	c.(34-36)TTG>TTC	p.L12F	TNFAIP3_uc003qhs.2_Missense_Mutation_p.L12F	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	12					anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CTTTGTATTTGAGCAATATGC	0.388		NaN	D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma						OREG0031869	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.870114	0	88	136									
MAGI2	9863	broad.mit.edu	37	7	77797280	77797280	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:77797280C>T	uc003ugx.2	-	15	2803	c.2549G>A	c.(2548-2550)CGC>CAC	p.R850H	MAGI2_uc003ugy.2_Missense_Mutation_p.R836H|MAGI2_uc010ldx.1_Missense_Mutation_p.R443H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	850	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGCCCATTGCGGGCTGCGTG	0.547		NaN											0	0	0	0.870114	0	82	145									
CNPY4	245812	broad.mit.edu	37	7	99722457	99722457	+	Silent	SNP	A	A	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:99722457A>G	uc003uto.2	+	6	796	c.693A>G	c.(691-693)GGA>GGG	p.G231G	MBLAC1_uc003utp.2_5'Flank	NM_152755	NP_689968	Q8N129	CNPY4_HUMAN	canopy 4 homolog precursor	231						extracellular region					0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					aggaaggggGAGACAAGATGA	0.388		NaN											0	0	0	0.870114	0	181	260									
LMOD2	442721	broad.mit.edu	37	7	123302716	123302716	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:123302716G>A	uc003vky.2	+	2	1233	c.1076G>A	c.(1075-1077)CGT>CAT	p.R359H		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	359						cytoskeleton	actin binding|tropomyosin binding				0						AGGCAAAAACGTTTGCAGGAG	0.463		NaN											0	0	0	0.870114	0	58	77									
UBE3C	9690	broad.mit.edu	37	7	157060438	157060438	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:157060438G>C	uc010lqs.2	+	23	3553	c.3241G>C	c.(3241-3243)GAG>CAG	p.E1081Q	UBE3C_uc003wni.3_Missense_Mutation_p.E444Q	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	1081	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CGCTGGCTTTGAGCTGAGCTG	0.547		NaN											0	0	0	0.870114	0	104	130									
ZFHX4	79776	broad.mit.edu	37	8	77767336	77767336	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:77767336T>C	uc003yav.2	+	10	8431	c.8044T>C	c.(8044-8046)TAC>CAC	p.Y2682H	ZFHX4_uc003yau.1_Missense_Mutation_p.Y2727H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Y2682H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2682						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCCACAGAAATACATCTATTT	0.428		NaN								HNSCC(33;0.089)			0	0	0	0.411799	0	13	40									
UBR5	51366	broad.mit.edu	37	8	103277452	103277452	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:103277452C>G	uc003ykr.1	-	53	7510	c.7477G>C	c.(7477-7479)GAT>CAT	p.D2493H	UBR5_uc003yks.1_Missense_Mutation_p.D2492H|UBR5_uc003ykq.2_Missense_Mutation_p.D4H	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2493	Asp/Glu-rich (acidic).|HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding	p.D2493V(1)		lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCTGTATCATCTAAATCCATA	0.423		NaN											0	0	0	0.870114	0	78	38									
ODF1	4956	broad.mit.edu	37	8	103564035	103564035	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:103564035G>T	uc003ykt.2	+	1	188	c.80G>T	c.(79-81)TGC>TTC	p.C27F		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	27					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CAACTGAGATGCATCGACGAA	0.483		NaN											1	0	3.12118e-38	0.870114	3.614e-38	79	285									
AZIN1	51582	broad.mit.edu	37	8	103851004	103851004	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:103851004C>T	uc003ykx.2	-	6	1159	c.417G>A	c.(415-417)TTG>TTA	p.L139L	AZIN1_uc003yky.2_Silent_p.L139L	NM_015878	NP_056962	O14977	AZIN1_HUMAN	ornithine decarboxylase antizyme inhibitor	139					polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	catalytic activity|protein binding				0	Lung NSC(17;0.000143)|all_lung(17;0.000294)		OV - Ovarian serous cystadenocarcinoma(57;0.000196)|STAD - Stomach adenocarcinoma(118;0.0414)			CAATTTTCTTCAATTCAATTT	0.328		NaN											0	0	0	0.624587	0	22	79									
CSMD3	114788	broad.mit.edu	37	8	113694715	113694715	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:113694715A>C	uc003ynu.2	-	16	2792	c.2633T>G	c.(2632-2634)ATG>AGG	p.M878R	CSMD3_uc003yns.2_Missense_Mutation_p.M150R|CSMD3_uc003ynt.2_Missense_Mutation_p.M838R|CSMD3_uc011lhx.1_Missense_Mutation_p.M774R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	878	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTTCCATCCATAAGAATACA	0.358		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.870114	0	53	114									
TAF2	6873	broad.mit.edu	37	8	120807793	120807793	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:120807793C>A	uc003you.2	-	9	1440	c.1170G>T	c.(1168-1170)GAG>GAT	p.E390D		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	390					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATGGCGGTACTCATTAACAC	0.343		NaN											1	0	8.60227e-14	0.500413	8.95858e-14	17	74									
BAI1	575	broad.mit.edu	37	8	143565371	143565371	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:143565371G>C	uc003ywm.2	+	11	2347	c.2164G>C	c.(2164-2166)GAG>CAG	p.E722Q		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	722	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCTGTTGGCAGAGGAGAATCG	0.587		NaN											0	0	0	0.870114	0	93	461									
ZNF250	58500	broad.mit.edu	37	8	146108082	146108082	+	Silent	SNP	C	C	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:146108082C>G	uc003zeq.3	-	6	618	c.501G>C	c.(499-501)CTG>CTC	p.L167L	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.L162L|ZNF250_uc010mgg.2_Silent_p.L162L	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		AGTTTGGACTCAGACAGAAGC	0.478		NaN											0	0	0	0.870114	0	110	371									
TPM2	7169	broad.mit.edu	37	9	35685657	35685657	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:35685657C>T	uc003zxq.2	-	3	600	c.361G>A	c.(361-363)GAT>AAT	p.D121N	TPM2_uc003zxr.2_Missense_Mutation_p.D121N|TPM2_uc003zxs.2_Missense_Mutation_p.D121N|TPM2_uc010mkz.2_Missense_Mutation_p.D121N|TPM2_uc011lpa.1_Missense_Mutation_p.D121N	NM_213674	NP_998839	P07951	TPM2_HUMAN	tropomyosin 2 (beta) isoform 2	121	By similarity.				muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			ovary(1)	1	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCGCTCTCATCAGCCGCCTTC	0.672		NaN											0	0	0	0.870114	0	84	112									
ALG2	85365	broad.mit.edu	37	9	101984145	101984145	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:101984145G>A	uc004azf.2	-	1	102	c.32C>T	c.(31-33)TCG>TTG	p.S11L	ALG2_uc004azg.2_5'UTR|SEC61B_uc004azh.2_5'Flank	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	11					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				CTTGGGAACCGAGTCCCGTTC	0.726		NaN											0	0	0	0.557998	0	18	27									
SNX30	401548	broad.mit.edu	37	9	115600917	115600917	+	Silent	SNP	C	C	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:115600917C>T	uc004bgj.3	+	6	1102	c.954C>T	c.(952-954)GAC>GAT	p.D318D	SNX30_uc004bgi.3_5'UTR	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	318					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						TGACAGATGACATGACAGAAG	0.483		NaN											0	0	0	0.827153	0	38	98									
AR	367	broad.mit.edu	37	X	66765006	66765006	+	Silent	SNP	G	G	A			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chrX:66765006G>A	uc004dwu.1	+	1	1133	c.18G>A	c.(16-18)GGG>GGA	p.G6G	AR_uc011mpd.1_Silent_p.G6G|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Silent_p.G6G	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	6	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TGCAGTTAGGGCTGGGAAGGG	0.577		NaN							Androgen_Insensitivity_Syndrome				0	0	0	0.827153	0	37	8									
KIAA1210	57481	broad.mit.edu	37	X	118220587	118220587	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chrX:118220587A>G	uc004era.3	-	11	4606	c.4606T>C	c.(4606-4608)TCT>CCT	p.S1536P		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1536										ovary(4)|skin(1)	5						GCAACGTAAGATATTTTGGTG	0.512		NaN											0	0	0	0.870114	0	53	15									
ARID1A	8289	broad.mit.edu	37	1	27105930	27105931	+	Frame_Shift_Ins	INS	-	-	G	rs140055856		TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:27105930_27105931insG	uc001bmv.1	+	20	5914_5915	c.5541_5542insG	c.(5539-5544)GGTGGGfs	p.G1847fs	ARID1A_uc001bmu.1_Frame_Shift_Ins_p.G1630fs|ARID1A_uc001bmx.1_Frame_Shift_Ins_p.G693fs|ARID1A_uc009vsm.1_Frame_Shift_Ins_p.G175fs|ARID1A_uc009vsn.1_Frame_Shift_Ins_p.G89fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1847_1848					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.G1848fs*6(3)|p.G1847fs*36(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCGGATTGGTGGGGGGGACAC	0.579		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								NaN	NaN	NaN	NaN	NaN	70	100	---	---							
SLC24A1	9187	broad.mit.edu	37	15	65918024	65918025	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:65918024_65918025insT	uc010ujf.1	+	2	1893_1894	c.1606_1607insT	c.(1606-1608)ATTfs	p.I536fs	SLC24A1_uc010ujd.1_Frame_Shift_Ins_p.I536fs|SLC24A1_uc010uje.1_Frame_Shift_Ins_p.I536fs|SLC24A1_uc010ujg.1_Frame_Shift_Ins_p.I536fs|SLC24A1_uc010ujh.1_Frame_Shift_Ins_p.I536fs	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	536	Helical; (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TGTGTTCAACATTCTCTTTGTC	0.525		NaN											NaN	NaN	NaN	NaN	NaN	69	150	---	---							
NDE1	54820	broad.mit.edu	37	16	15790770	15790770	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:15790770delG	uc002ddt.1	+	7	1043	c.1000delG	c.(1000-1002)GGCfs	p.G334fs	NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	Error:Variant_position_missing_in_Q9NXR1_after_alignment					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						GCCTGCCCCAGGCAAGAGACA	0.552		NaN											NaN	NaN	NaN	NaN	NaN	18	27	---	---							
CNOT1	23019	broad.mit.edu	37	16	58619315	58619316	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:58619315_58619316delCT	uc002env.2	-	8	1025_1026	c.732_733delAG	c.(730-735)GGAGGGfs	p.G244fs	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Frame_Shift_Del_p.G244fs|CNOT1_uc002enx.2_Frame_Shift_Del_p.G244fs|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	244_245					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTAGCTACCCCTCCGGAATCAG	0.465		NaN											NaN	NaN	NaN	NaN	NaN	62	169	---	---							
VEZF1	7716	broad.mit.edu	37	17	56056586	56056587	+	In_Frame_Ins	INS	-	-	TGT			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:56056586_56056587insTGT	uc002ivf.1	-	5	1207_1208	c.1064_1065insACA	c.(1063-1065)CAT>CAACAT	p.354_355insQ	VEZF1_uc010dcn.1_In_Frame_Ins_p.204_205insQ	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	354_355					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						AGCTTGTCACAtgttgttgttg	0.317		NaN											NaN	NaN	NaN	NaN	NaN	7	480	---	---							
DOCK6	57572	broad.mit.edu	37	19	11348960	11348960	+	Frame_Shift_Del	DEL	G	G	-	rs12609039	by1000genomes	TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:11348960delG	uc002mqs.3	-	15	1705	c.1664delC	c.(1663-1665)CCGfs	p.P555fs	DOCK6_uc010xlq.1_5'Flank|LOC55908_uc010dxw.2_Intron|LOC55908_uc010dxx.2_Intron	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	555	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GAGGCTGTGCGGGTACACGTA	0.647		NaN											NaN	NaN	NaN	NaN	NaN	22	48	---	---							
FFAR2	2867	broad.mit.edu	37	19	35940788	35940790	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:35940788_35940790delCTG	uc002nzg.2	+	2	252_254	c.172_174delCTG	c.(172-174)CTGdel	p.L62del	FFAR2_uc010eea.2_In_Frame_Del_p.L62del	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	62	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACCTCCTCCTGCTGCTGCTGC	0.645		NaN											NaN	NaN	NaN	NaN	NaN	7	135	---	---							
TBP	6908	broad.mit.edu	37	6	170871013	170871014	+	In_Frame_Ins	INS	-	-	CAG	rs72320253		TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:170871013_170871014insCAG	uc003qxt.2	+	3	421_422	c.189_190insCAG	c.(187-192)insCAG	p.95_96insQ	TBP_uc003qxu.2_In_Frame_Ins_p.95_96insQ|TBP_uc011ehf.1_In_Frame_Ins_p.75_76insQ|TBP_uc011ehg.1_In_Frame_Ins_p.95_96insQ	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	95_96					cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacaacaacagcagcagca	0.183		NaN											NaN	NaN	NaN	NaN	NaN	34	84	---	---							
MLL3	58508	broad.mit.edu	37	7	151873966	151873967	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			-	AG	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:151873966_151873967insAG	uc003wla.2	-	38	8790_8791	c.8571_8572insCT	c.(8569-8574)TCTGCTfs	p.S2857fs	MLL3_uc003wkz.2_Frame_Shift_Ins_p.S1918fs|MLL3_uc003wky.2_Frame_Shift_Ins_p.S366fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2857_2858					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTGAGTGAGCAGAAGCCTGTG	0.411		NaN	N		medulloblastoma								NaN	NaN	NaN	NaN	NaN	48	119	---	---							
OSR2	116039	broad.mit.edu	37	8	99961401	99961402	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:99961401_99961402insG	uc003yir.2	+	2	756_757	c.221_222insG	c.(220-222)GCGfs	p.A74fs	OSR2_uc010mbn.2_Frame_Shift_Ins_p.A74fs|OSR2_uc003yiq.2_Frame_Shift_Ins_p.A74fs|OSR2_uc011lgx.1_Frame_Shift_Ins_p.A195fs	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	74					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			GAGATGGCGGCGGCGCAGGGCC	0.649		NaN											NaN	NaN	NaN	NaN	NaN	8	510	---	---							
C9orf150	286343	broad.mit.edu	37	9	12775861	12775862	+	In_Frame_Ins	INS	-	-	GGCGGCGGC	rs139315731	by1000genomes	TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:12775861_12775862insGGCGGCGGC	uc003zkw.2	+	1	850_851	c.147_148insGGCGGCGGC	c.(145-150)insGGCGGCGGC	p.55_56insGGG		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	58_59	Gly-rich.										0				GBM - Glioblastoma multiforme(1;1.64e-13)		gcggtggtggtggcggcggcgg	0.505		NaN											NaN	NaN	NaN	NaN	NaN	10	11	---	---