Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CDK11B	984	broad.mit.edu	37	1	1572548	1572548	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:1572548C>G	uc001agv.1	-	19	1698	c.1587G>C	c.(1585-1587)CTG>CTC	p.L529L	CDK11B_uc009vkj.2_Silent_p.L186L|CDK11B_uc001ags.1_Silent_p.L387L|CDK11B_uc001agt.1_Silent_p.L312L|CDK11B_uc001aha.1_Silent_p.L495L|CDK11B_uc001agw.1_Silent_p.L484L|CDK11B_uc001agy.1_Silent_p.L527L|CDK11B_uc001agx.1_Silent_p.L518L|CDK11B_uc001agz.1_Silent_p.L273L	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	542	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						GCTGGATCATCAGGGTCTTCA	0.652		NaN											0	0	0	1	0	6	88									
CDK11A	728642	broad.mit.edu	37	1	1635767	1635767	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:1635767C>G	uc009vks.2	-	15	1689	c.1581G>C	c.(1579-1581)CTG>CTC	p.L527L	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Silent_p.L34L|CDK11A_uc009vkp.2_Silent_p.L144L|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Silent_p.L517L|CDK11A_uc010nys.1_3'UTR	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	530	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GCTGGATCATCAGGGTCTTCA	0.672		NaN											0	0	0	1	0	10	36									
MEGF6	1953	broad.mit.edu	37	1	3511904	3511904	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:3511904G>C	uc001akl.2	-	3	601	c.374C>G	c.(373-375)TCG>TGG	p.S125W		NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	125	EGF-like 1.|EMI.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCACTCACCCGAGAGGCAGCC	0.682		NaN											0	0	0	1	0	40	39									
KIF1B	23095	broad.mit.edu	37	1	10342591	10342591	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:10342591G>A	uc001aqx.3	+	15	1636	c.1434G>A	c.(1432-1434)AAG>AAA	p.K478K	KIF1B_uc001aqv.3_Silent_p.K432K|KIF1B_uc001aqw.3_Silent_p.K432K|KIF1B_uc001aqy.2_Silent_p.K452K|KIF1B_uc001aqz.2_Silent_p.K478K|KIF1B_uc001ara.2_Silent_p.K438K|KIF1B_uc001arb.2_Silent_p.K464K	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	478	Potential.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AACGTTTAAAGGTAAGTAATA	0.294		NaN											0	0	0	1	0	41	89									
FBXO2	26232	broad.mit.edu	37	1	11708844	11708844	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:11708844G>A	uc001asj.2	-	6	1140	c.798C>T	c.(796-798)TTC>TTT	p.F266F	FBXO2_uc009vna.2_Silent_p.F269F	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	266	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CGAAGCGGACGAAGCGGACGC	0.677		NaN											0	0	0	1	0	137	103									
VPS13D	55187	broad.mit.edu	37	1	12337497	12337497	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:12337497C>G	uc001atv.2	+	19	3993	c.3852C>G	c.(3850-3852)CTC>CTG	p.L1284L	VPS13D_uc001atw.2_Silent_p.L1284L|VPS13D_uc001atx.2_Silent_p.L472L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1284					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGTGTTTTCTCAACCTGAAGA	0.398		NaN											0	0	0	1	0	125	134									
UBR4	23352	broad.mit.edu	37	1	19477120	19477120	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:19477120C>T	uc001bbi.2	-	49	7385	c.7381G>A	c.(7381-7383)GAT>AAT	p.D2461N	UBR4_uc001bbk.1_Missense_Mutation_p.D115N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2461					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GAGTCGCTATCTCCAGTGCCG	0.547		NaN											0	0	0	1	0	203	205									
LDLRAD2	401944	broad.mit.edu	37	1	22141309	22141309	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:22141309C>T	uc001bfg.1	+	2	691	c.504C>T	c.(502-504)TTC>TTT	p.F168F		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	168	Extracellular (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		TCACCTCTTTCCGTCTGGGTG	0.711		NaN											0	0	0	1	0	8	9									
C1orf213	148898	broad.mit.edu	37	1	23695890	23695890	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:23695890C>T	uc001bgw.2	+	1	427	c.100C>T	c.(100-102)CGT>TGT	p.R34C	ZNF436_uc001bgt.2_5'Flank|ZNF436_uc001bgu.2_5'UTR|C1orf213_uc001bgv.2_Missense_Mutation_p.R34C	NM_138479	NP_612488			hypothetical protein LOC148898 isoform 1												0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.97e-26)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;5.23e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		ACTAGATCGTCGTCTCCAAAA	0.572		NaN											0	0	0	1	0	34	47									
ARID1A	8289	broad.mit.edu	37	1	27106492	27106492	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:27106492G>T	uc001bmv.1	+	20	6476	c.6103G>T	c.(6103-6105)GAG>TAG	p.E2035*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.E1818*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.E881*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.E363*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.E277*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2035					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGAAAAGGAGGAGGAACAGGA	0.557		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								1	0	2.47907e-22	1	2.60217e-22	54	100									
SFN	2810	broad.mit.edu	37	1	27189727	27189727	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:27189727G>A	uc001bnc.1	+	1	95	c.24G>A	c.(22-24)CAG>CAA	p.Q8Q		NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	8					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		GTCTGATCCAGAAGGCCAAGC	0.627		NaN											0	0	0	1	0	76	85									
SDC3	9672	broad.mit.edu	37	1	31347175	31347175	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:31347175C>T	uc001bse.2	-	4	1178	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	SDC3_uc001bsd.2_Silent_p.K319K	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	377	Extracellular (Potential).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGATACTCTTCTGAGGCA	0.652		NaN											0	0	0	1	0	38	46									
TMEM54	113452	broad.mit.edu	37	1	33363913	33363913	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:33363913C>G	uc001bwi.1	-	2	138	c.24G>C	c.(22-24)CTG>CTC	p.L8L	TMEM54_uc001bwj.1_Silent_p.L8L|TMEM54_uc001bwk.1_Silent_p.L8L	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	8						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CGCCCACACTCAGGCCTCCTG	0.617		NaN											0	0	0	1	0	44	55									
CSMD2	114784	broad.mit.edu	37	1	33987087	33987087	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:33987087C>G	uc001bxn.1	-	67	10170	c.10141G>C	c.(10141-10143)GGG>CGG	p.G3381R	CSMD2_uc001bxm.1_Missense_Mutation_p.G3525R	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3381	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCGAACTGCCCAAAGCCTTGG	0.602		NaN											0	0	0	1	0	37	69									
ZMYM6	9204	broad.mit.edu	37	1	35485180	35485180	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:35485180G>A	uc001byh.2	-	4	430	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	ZMYM6_uc001byf.1_Nonsense_Mutation_p.Q68*|ZMYM6_uc010oht.1_5'UTR|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Nonsense_Mutation_p.Q68*|ZMYM6_uc009vur.1_Intron|ZMYM6_uc001byj.2_Nonsense_Mutation_p.Q68*|ZMYM6_uc001byi.2_Nonsense_Mutation_p.Q68*|ZMYM6_uc001byk.2_Nonsense_Mutation_p.Q68*	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	68					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AAAGAAAGCTGAAAGCCTGGG	0.368		NaN											0	0	0	1	0	22	39									
CLSPN	63967	broad.mit.edu	37	1	36211080	36211080	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:36211080G>C	uc001bzi.2	-	16	3018	c.2938C>G	c.(2938-2940)CTT>GTT	p.L980V	CLSPN_uc009vux.2_Missense_Mutation_p.L916V	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	980	CKB motif 3.				activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCTGAGCAAAGAGCAAGTGCT	0.438		NaN											0	0	0	1	0	30	42									
MANEAL	149175	broad.mit.edu	37	1	38265658	38265658	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:38265658C>T	uc001cby.2	+	4	1238	c.1157C>T	c.(1156-1158)ACG>ATG	p.T386M	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.T164M	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	386	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TACTATGAGACGGCCCTGCAG	0.567		NaN											0	0	0	1	0	47	60									
TESK2	10420	broad.mit.edu	37	1	45811074	45811074	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:45811074G>C	uc001cns.1	-	11	1557	c.1154C>G	c.(1153-1155)CCA>CGA	p.P385R	TESK2_uc009vxr.1_Missense_Mutation_p.P356R|TESK2_uc010olo.1_Missense_Mutation_p.P302R|TESK2_uc009vxs.1_Missense_Mutation_p.P177R	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	385					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					CCGGTAGTATGGGTCCAAGAC	0.557		NaN											0	0	0	1	0	55	48									
IPP	3652	broad.mit.edu	37	1	46212053	46212053	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:46212053C>T	uc001cou.2	-	2	298	c.31G>A	c.(31-33)GAT>AAT	p.D11N	IPP_uc001cos.3_Missense_Mutation_p.D11N	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	11						actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AAAGGACTATCAGCAGCCTTG	0.408		NaN											0	0	0	1	0	48	118									
LRRC41	10489	broad.mit.edu	37	1	46751935	46751935	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:46751935G>C	uc001cpn.2	-	4	638	c.594C>G	c.(592-594)CTC>CTG	p.L198L	LRRC41_uc010omb.1_Silent_p.L198L|LRRC41_uc001cpo.1_Silent_p.L198L	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	198										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GGCGGAACTTGAGAGTGTGCA	0.592		NaN											0	0	0	1	0	40	45									
HOOK1	51361	broad.mit.edu	37	1	60297859	60297859	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:60297859C>T	uc009wad.2	+	5	349	c.247C>T	c.(247-249)CAA>TAA	p.Q83*	HOOK1_uc001czo.2_Nonsense_Mutation_p.Q83*|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Nonsense_Mutation_p.Q41*	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	83	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					GAAGGTCCTTCAAGGAATTAT	0.289		NaN											0	0	0	1	0	56	85									
IFI44L	10964	broad.mit.edu	37	1	79093672	79093672	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:79093672G>C	uc010oro.1	+	2	251	c.72G>C	c.(70-72)TTG>TTC	p.L24F	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	24						cytoplasm					0						ATGTTTCTTTGAGTCTTCTCT	0.363		NaN											0	0	0	1	0	32	24									
SEP15	9403	broad.mit.edu	37	1	87379771	87379771	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:87379771C>G	uc010osi.1	-	1	337	c.24G>C	c.(22-24)CCG>CCC	p.P8P	HS2ST1_uc001dmc.3_5'Flank|HS2ST1_uc010osk.1_5'Flank|SEP15_uc010osj.1_Silent_p.P8P	NM_004261	NP_004252	O60613	SEP15_HUMAN	15 kDa selenoprotein isoform 1 precursor	5					'de novo' posttranslational protein folding	endoplasmic reticulum lumen	selenium binding				0		Lung NSC(277;0.153)		all cancers(265;0.00744)|Epithelial(280;0.0333)		GACACCCACTCGGCCCAGCCG	0.587		NaN											0	0	0	1	0	53	74									
LRRC8C	84230	broad.mit.edu	37	1	90179371	90179371	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:90179371G>A	uc001dnl.3	+	3	1484	c.1242G>A	c.(1240-1242)CTG>CTA	p.L414L		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	414	LRR 1.					endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CTGATAAACTGAGGCAGAAGC	0.413		NaN											0	0	0	1	0	41	53									
SNX7	51375	broad.mit.edu	37	1	99150470	99150470	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:99150470C>G	uc010ouc.1	+	2	262	c.210C>G	c.(208-210)TTC>TTG	p.F70L	SNX7_uc001dsa.2_Missense_Mutation_p.F6L|SNX7_uc010oud.1_Missense_Mutation_p.F70L	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	6					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		TGAACTCCTTCAGCCCTATGA	0.338		NaN											0	0	0	1	0	50	85									
FAM40A	85369	broad.mit.edu	37	1	110591786	110591786	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:110591786G>C	uc001dza.1	+	16	1733	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	FAM40A_uc001dyz.1_Missense_Mutation_p.E477Q|FAM40A_uc009wfp.1_Missense_Mutation_p.E396Q	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	572						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		CCGCCACAAAGAGGTCATTGT	0.522		NaN											0	0	0	1	0	30	50									
FAM40A	85369	broad.mit.edu	37	1	110592108	110592108	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:110592108G>A	uc001dza.1	+	17	1834	c.1815G>A	c.(1813-1815)GTG>GTA	p.V605V	FAM40A_uc001dyz.1_Silent_p.V510V|FAM40A_uc009wfp.1_Silent_p.V429V	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	605						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		AGCACCTGGTGTTTGCCAACT	0.473		NaN											0	0	0	1	0	57	72									
PPM1J	333926	broad.mit.edu	37	1	113253221	113253221	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:113253221C>G	uc001ect.1	-	9	1258	c.1231G>C	c.(1231-1233)GAC>CAC	p.D411H	PPM1J_uc009wgl.1_RNA|PPM1J_uc001ecs.1_Missense_Mutation_p.D205H	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	411	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTGTCAGGTCATACACTCGT	0.532		NaN											0	0	0	1	0	90	125									
OLFML3	56944	broad.mit.edu	37	1	114523069	114523069	+	Missense_Mutation	SNP	G	G	C	rs144544470	by1000genomes	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:114523069G>C	uc001eer.1	+	2	339	c.230G>C	c.(229-231)AGA>ACA	p.R77T	OLFML3_uc001ees.1_Missense_Mutation_p.R57T|OLFML3_uc001eet.1_5'UTR	NM_020190	NP_064575	Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3 precursor	77	Potential.				multicellular organismal development	extracellular region					0	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGCACTCAGAACTGAGGCC	0.587		NaN											0	0	0	1	0	40	71									
TRIM45	80263	broad.mit.edu	37	1	117656050	117656050	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:117656050G>A	uc001egz.2	-	5	2113	c.1525C>T	c.(1525-1527)CAC>TAC	p.H509Y	TRIM45_uc009whe.2_Missense_Mutation_p.H491Y|TRIM45_uc001eha.2_Missense_Mutation_p.H405Y	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	509						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		GTGCAGCAGTGAAACACGCCT	0.572		NaN											0	0	0	1	0	48	39									
FAM72D	728833	broad.mit.edu	37	1	143912363	143912363	+	Translation_Start_Site	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:143912363G>C	uc002qvn.1	-	1	781	c.-67C>G	c.(-69--65)ATCAA>ATGAA		FAM72D_uc010evy.1_Translation_Start_Site	NM_207418	NP_997301	Q6L9T8	FA72D_HUMAN	hypothetical protein LOC653573												0						CTACTATTTTGATTCCCCTAG	0.418		NaN											0	0	0	1	0	41	80									
PDE4DIP	9659	broad.mit.edu	37	1	144882814	144882814	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:144882814C>T	uc001elw.3	-	24	3496	c.3205G>A	c.(3205-3207)GAT>AAT	p.D1069N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.D1135N|PDE4DIP_uc001elv.3_Missense_Mutation_p.D76N	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1069					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCATCCATCAGACATTGCT	0.512		NaN	T	PDGFRB	MPD								0	0	0	1	0	116	494									
PDE4DIP	9659	broad.mit.edu	37	1	145075664	145075664	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145075664C>A	uc001emh.2	-	1	416	c.199G>T	c.(199-201)GAA>TAA	p.E67*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Nonsense_Mutation_p.E67*|PDE4DIP_uc001emk.2_Nonsense_Mutation_p.E67*	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTGCTTCTTCCTCCTCGGCC	0.721		NaN	T	PDGFRB	MPD								1	0	6.05902e-23	1	6.3708e-23	25	208									
NOTCH2NL	388677	broad.mit.edu	37	1	145281491	145281491	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145281491G>A	uc001emn.3	+	4	791	c.421G>A	c.(421-423)GAG>AAG	p.E141K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.E141K|NOTCH2NL_uc001emo.2_Missense_Mutation_p.E141K|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	141	EGF-like 4.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GCAGAAGTGTGAGACTGATGT	0.552		NaN											0	0	0	1	0	64	553									
TXNIP	10628	broad.mit.edu	37	1	145439874	145439874	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145439874G>C	uc001enn.3	+	3	761	c.420G>C	c.(418-420)AAG>AAC	p.K140N	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.K85N	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	140					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGAGACAAAGAAAAACTTTG	0.438		NaN											0	0	0	1	0	62	68									
TXNIP	10628	broad.mit.edu	37	1	145440123	145440123	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145440123G>A	uc001enn.3	+	4	898	c.557G>A	c.(556-558)AGA>AAA	p.R186K	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.R131K	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	186					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGAATTGACAGAAAAGGATTC	0.458		NaN											0	0	0	1	0	101	142									
ADAMTSL4	54507	broad.mit.edu	37	1	150532597	150532597	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:150532597C>T	uc001eux.2	+	19	3386	c.3150C>T	c.(3148-3150)GTC>GTT	p.V1050V	ADAMTSL4_uc009wlw.2_Silent_p.V1073V|ADAMTSL4_uc010pcg.1_Silent_p.V1011V|ADAMTSL4_uc009wlx.2_Silent_p.V213V	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	1050	PLAC.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GGCTCTGCGTCTACCCCTACT	0.622		NaN									OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	89	131									
SEMA6C	10500	broad.mit.edu	37	1	151111130	151111130	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:151111130G>C	uc001ewu.2	-	7	732	c.432C>G	c.(430-432)TTC>TTG	p.F144L	SEMA6C_uc001ewv.2_Missense_Mutation_p.F144L|SEMA6C_uc001eww.2_Missense_Mutation_p.F144L|SEMA6C_uc010pcq.1_Missense_Mutation_p.F144L|SEMA6C_uc009wml.1_RNA	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	144	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACACAGGGCTGAATGAGTTCG	0.527		NaN											0	0	0	1	0	36	53									
RFX5	5993	broad.mit.edu	37	1	151316209	151316209	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:151316209G>A	uc001exv.1	-	9	919	c.705C>T	c.(703-705)CTC>CTT	p.L235L	RFX5_uc001exw.1_Silent_p.L235L|RFX5_uc009wmr.1_Silent_p.L235L|RFX5_uc010pcx.1_Silent_p.L195L	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	235						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGCAGAGATGAGATGCTGCT	0.582		NaN											0	0	0	1	0	40	66									
ASH1L	55870	broad.mit.edu	37	1	155365333	155365333	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:155365333C>T	uc009wqq.2	-	7	6500	c.6020G>A	c.(6019-6021)CGA>CAA	p.R2007Q	ASH1L_uc001fkt.2_Missense_Mutation_p.R2007Q	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2007					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTGGATCAATCGACTCTTTGG	0.413		NaN											0	0	0	1	0	28	42									
LMNA	4000	broad.mit.edu	37	1	156100507	156100507	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:156100507C>G	uc001fni.2	+	2	705	c.456C>G	c.(454-456)CTC>CTG	p.L152L	LMNA_uc001fnf.1_Silent_p.L152L|LMNA_uc001fng.2_Silent_p.L152L|LMNA_uc001fnh.2_Silent_p.L152L|LMNA_uc009wro.1_Silent_p.L152L|LMNA_uc010pgz.1_Silent_p.L40L|LMNA_uc001fnj.2_Silent_p.L71L|LMNA_uc001fnk.2_Silent_p.L53L	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	152	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					GCACTGCTCTCAGTGAGAAGC	0.637		NaN							Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome		OREG0013866	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	14	19									
SMG5	23381	broad.mit.edu	37	1	156230322	156230322	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:156230322G>A	uc001foc.3	-	15	2352	c.2203C>T	c.(2203-2205)CGT>TGT	p.R735C	SMG5_uc009wrv.2_Missense_Mutation_p.R220C	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	735					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GGCAGGTTACGAAGAGCCATG	0.562		NaN											0	0	0	1	0	46	63									
NES	10763	broad.mit.edu	37	1	156639156	156639156	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:156639156C>G	uc001fpq.2	-	4	4957	c.4824G>C	c.(4822-4824)CAG>CAC	p.Q1608H		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1608	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCCTTCCCTCTGAGTGAACT	0.617		NaN											0	0	0	1	0	33	59									
FCRL3	115352	broad.mit.edu	37	1	157665209	157665209	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:157665209G>A	uc001frb.2	-	8	1613	c.1321C>T	c.(1321-1323)CTG>TTG	p.L441L	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.L441L|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.L167L|FCRL3_uc001frc.1_Silent_p.L441L	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	441	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TCTGCAGTCAGAGAGAGGTTG	0.557		NaN											0	0	0	1	0	90	131									
CADM3	57863	broad.mit.edu	37	1	159169587	159169587	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:159169587C>T	uc001ftl.2	+	8	1141	c.999C>T	c.(997-999)ATC>ATT	p.I333I	CADM3_uc001ftk.2_Silent_p.I367I|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	333	Helical; (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					ACGCCATCATCGGTGGGATCG	0.542		NaN											0	0	0	1	0	73	75									
COPA	1314	broad.mit.edu	37	1	160262955	160262955	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:160262955C>T	uc009wti.2	-	27	3217	c.2823_splice	c.e27+1	p.R941_splice	COPA_uc001fvv.3_Splice_Site_p.R950_splice	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform						COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGTTACTTACCCGCATGGCT	0.468		NaN											0	0	0	1	0	51	226									
CD48	962	broad.mit.edu	37	1	160681499	160681499	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:160681499G>A	uc001fwn.2	-	1	87	c.55C>T	c.(55-57)CTG>TTG	p.L19L	CD48_uc001fwo.1_Silent_p.L19L|CD48_uc001fwp.2_Silent_p.L19L	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	19					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AGGAGTGACAGAGGCAGCAGT	0.532		NaN											0	0	0	1	0	34	57									
GPA33	10223	broad.mit.edu	37	1	167038281	167038281	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:167038281G>C	uc001gea.1	-	3	637	c.293C>G	c.(292-294)TCC>TGC	p.S98C		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	98	Ig-like V-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						GGAGGCATCGGACTGCTCAGC	0.502		NaN											0	0	0	1	0	34	46									
CD247	919	broad.mit.edu	37	1	167408587	167408587	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:167408587G>C	uc001gei.3	-	3	358	c.213C>G	c.(211-213)CTC>CTG	p.L71L	CD247_uc001gej.3_Silent_p.L71L|CD247_uc001gek.2_Silent_p.L71L	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	71	Cytoplasmic (Potential).|ITAM 1.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TTACGTTATAGAGCTGGTTCT	0.572		NaN											0	0	0	1	0	53	103									
GPR161	23432	broad.mit.edu	37	1	168056841	168056841	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:168056841C>A	uc001gfc.2	-	7	1620	c.1306G>T	c.(1306-1308)GAA>TAA	p.E436*	GPR161_uc001gfb.2_Nonsense_Mutation_p.E304*|GPR161_uc010pll.1_Nonsense_Mutation_p.E346*|GPR161_uc010plm.1_Nonsense_Mutation_p.E322*|GPR161_uc009wvo.2_Nonsense_Mutation_p.E453*|GPR161_uc001gfd.2_Nonsense_Mutation_p.E436*|GPR161_uc010pln.1_Nonsense_Mutation_p.E456*	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	436	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					TGTTCCACTTCATCCTCAAAT	0.483		NaN											1	0	1.15365e-47	1	1.23418e-47	95	143									
TIPRL	261726	broad.mit.edu	37	1	168165852	168165852	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:168165852G>C	uc001gfg.2	+	5	729	c.584G>C	c.(583-585)AGA>ACA	p.R195T	TIPRL_uc001gfh.2_Missense_Mutation_p.R195T	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	195	Interaction with PPP2CA.				DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					GTGCTTATCAGAATGAATGAC	0.328		NaN											0	0	0	1	0	65	90									
NME7	29922	broad.mit.edu	37	1	169292506	169292506	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:169292506G>A	uc001gfu.2	-	3	365	c.127C>T	c.(127-129)CAT>TAT	p.H43Y	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.H7Y|NME7_uc001gfv.1_Missense_Mutation_p.H43Y	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	43	DM10.				CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					AAGGTGCGATGATTCTTTACA	0.308		NaN											0	0	0	1	0	68	106									
SMG7	9887	broad.mit.edu	37	1	183518360	183518360	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:183518360G>T	uc001gqg.2	+	18	2882	c.2760G>T	c.(2758-2760)AAG>AAT	p.K920N	SMG7_uc001gqf.2_Missense_Mutation_p.K924N|SMG7_uc001gqh.2_Missense_Mutation_p.K874N|SMG7_uc001gqi.2_Missense_Mutation_p.K832N|SMG7_uc010poc.1_Missense_Mutation_p.K928N	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	920					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TATTGGAGAAGCCCTCAGAGC	0.388		NaN											1	0	9.72345e-25	1	1.02414e-24	41	42									
SMG7	9887	broad.mit.edu	37	1	183520021	183520021	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:183520021G>A	uc001gqg.2	+	20	3241	c.3119G>A	c.(3118-3120)AGA>AAA	p.R1040K	SMG7_uc001gqf.2_Missense_Mutation_p.R1044K|SMG7_uc001gqh.2_Missense_Mutation_p.R994K|SMG7_uc001gqi.2_Missense_Mutation_p.R952K|SMG7_uc010poc.1_Missense_Mutation_p.R1048K	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	1040					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AACAGGGATAGAAGGACTGCA	0.458		NaN											0	0	0	1	0	63	62									
GLT25D2	23127	broad.mit.edu	37	1	183920230	183920230	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:183920230G>C	uc001gqr.2	-	8	1419	c.1047C>G	c.(1045-1047)CTC>CTG	p.L349L	GLT25D2_uc010poj.1_Silent_p.L349L|GLT25D2_uc001gqq.2_Silent_p.L86L|GLT25D2_uc001gqs.2_Silent_p.L229L	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	349					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						TTCTGCGTTTGAGGTTTATCA	0.413		NaN											0	0	0	1	0	127	202									
NEK7	140609	broad.mit.edu	37	1	198262135	198262135	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:198262135C>T	uc001gun.3	+	8	977	c.650C>T	c.(649-651)TCT>TTT	p.S217F		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	217	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						AACTTCAAATCTGACATCTGG	0.323		NaN											0	0	0	1	0	133	170									
OPTC	26254	broad.mit.edu	37	1	203467966	203467966	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:203467966G>C	uc001gzu.1	+	4	644	c.528G>C	c.(526-528)CTG>CTC	p.L176L		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	176						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			TCAAAGGGCTGAGTATGTAAT	0.557		NaN											0	0	0	1	0	45	55									
IKBKE	9641	broad.mit.edu	37	1	206649607	206649607	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:206649607G>T	uc001hdz.1	+	6	810	c.442G>T	c.(442-444)GAG>TAG	p.E148*	IKBKE_uc009xbu.1_Nonsense_Mutation_p.E148*|IKBKE_uc009xbv.1_Nonsense_Mutation_p.E148*|IKBKE_uc001hea.1_Nonsense_Mutation_p.E63*	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	148	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CGTAGGGGAGGAGGGGCAGAG	0.607		NaN											1	0	5.5144e-22	1	5.76848e-22	59	81									
OBSCN	84033	broad.mit.edu	37	1	228467882	228467882	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:228467882C>T	uc009xez.1	+	29	7710	c.7666C>T	c.(7666-7668)CGG>TGG	p.R2556W	OBSCN_uc001hsn.2_Missense_Mutation_p.R2556W|OBSCN_uc001hsp.1_Missense_Mutation_p.R255W|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2556	Ig-like 24.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCTTGCAGCGCGGGAGGTGAC	0.642		NaN											0	0	0	1	0	55	73									
LYST	1130	broad.mit.edu	37	1	235929543	235929543	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:235929543C>T	uc001hxj.2	-	21	6132	c.5957G>A	c.(5956-5958)CGA>CAA	p.R1986Q	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1986					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACAAACCTCTCGGGGCATGGG	0.328		NaN							Chediak-Higashi_syndrome				0	0	0	1	0	121	123									
OR2L3	391192	broad.mit.edu	37	1	248224664	248224664	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:248224664G>A	uc001idx.1	+	1	681	c.681G>A	c.(679-681)ATG>ATA	p.M227I	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCTACCACATGAAATCTGCAG	0.468		NaN											0	0	0	1	0	92	158									
OR2M5	127059	broad.mit.edu	37	1	248309371	248309371	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:248309371G>T	uc010pze.1	+	1	922	c.922G>T	c.(922-924)GGC>TGC	p.G308C		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GTTAGGAAAGGGCAAGTGTGG	0.433		NaN											1	0	2.44723e-14	1	2.52127e-14	27	43									
DHTKD1	55526	broad.mit.edu	37	10	12139993	12139993	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:12139993C>G	uc001ild.3	+	8	1768	c.1669C>G	c.(1669-1671)CAG>GAG	p.Q557E		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	557					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GACACATGTTCAGGTGGGCAG	0.502		NaN											0	0	0	1	0	42	58									
CAMK1D	57118	broad.mit.edu	37	10	12811675	12811675	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:12811675G>A	uc001ilo.2	+	5	677	c.442G>A	c.(442-444)GAA>AAA	p.E148K	CAMK1D_uc001iln.2_Missense_Mutation_p.E148K	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	148	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		TTTCTAGCCCGAAAATCTCTT	0.388		NaN											0	0	0	1	0	28	27									
ERCC6	2074	broad.mit.edu	37	10	50682233	50682233	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:50682233G>A	uc001jhs.3	-	13	2592	c.2438C>T	c.(2437-2439)TCT>TTT	p.S813F	ERCC6_uc009xod.2_5'UTR|ERCC6_uc010qgr.1_Missense_Mutation_p.S183F|ERCC6_uc001jhr.3_Missense_Mutation_p.S181F	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	813					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GGGACCTCCAGAAAAGAGATC	0.413		NaN						Direct_reversal_of_damage|NER					0	0	0	1	0	54	62									
SLC18A3	6572	broad.mit.edu	37	10	50819248	50819248	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:50819248G>A	uc001jhw.2	+	1	902	c.462G>A	c.(460-462)CCG>CCA	p.P154P	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	154	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						ACGACGTGCCGCTGCTGATCG	0.637		NaN											0	0	0	1	0	45	150									
OGDHL	55753	broad.mit.edu	37	10	50955190	50955190	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:50955190C>T	uc001jie.2	-	9	1194	c.1052G>A	c.(1051-1053)CGG>CAG	p.R351Q	OGDHL_uc009xog.2_Missense_Mutation_p.R378Q|OGDHL_uc010qgt.1_Missense_Mutation_p.R294Q|OGDHL_uc010qgu.1_Missense_Mutation_p.R142Q|OGDHL_uc009xoh.2_Missense_Mutation_p.R142Q	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	351					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						AGTGATGTTCCGGTTGGTGAC	0.587		NaN											0	0	0	1	0	61	82									
PCDH15	65217	broad.mit.edu	37	10	55663071	55663071	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:55663071G>C	uc001jju.1	-	26	3828	c.3433C>G	c.(3433-3435)CAG>GAG	p.Q1145E	PCDH15_uc010qhq.1_Missense_Mutation_p.Q1150E|PCDH15_uc010qhr.1_Missense_Mutation_p.Q1145E|PCDH15_uc010qhs.1_Missense_Mutation_p.Q1157E|PCDH15_uc010qht.1_Missense_Mutation_p.Q1152E|PCDH15_uc010qhu.1_Missense_Mutation_p.Q1145E|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.Q1145E|PCDH15_uc010qhw.1_Missense_Mutation_p.Q1108E|PCDH15_uc010qhx.1_Missense_Mutation_p.Q1074E|PCDH15_uc010qhy.1_Missense_Mutation_p.Q1150E|PCDH15_uc010qhz.1_Missense_Mutation_p.Q1145E|PCDH15_uc010qia.1_Missense_Mutation_p.Q1123E|PCDH15_uc010qib.1_Missense_Mutation_p.Q1123E	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1145	Cadherin 11.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AATTTTTTCTGAAACACTGGG	0.353		NaN								HNSCC(58;0.16)			0	0	0	1	0	35	38									
HKDC1	80201	broad.mit.edu	37	10	71020971	71020971	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:71020971C>G	uc001jpf.3	+	16	2426	c.2293C>G	c.(2293-2295)CTC>GTC	p.L765V	HKDC1_uc010qje.1_Missense_Mutation_p.L628V|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	765					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						CAAGCAGGGTCTCCTCTTCCG	0.517		NaN											0	0	0	1	0	41	54									
CHCHD1	118487	broad.mit.edu	37	10	75542839	75542839	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:75542839G>A	uc001jvc.3	+	3	277	c.251G>A	c.(250-252)CGA>CAA	p.R84Q	CHCHD1_uc001jvb.2_3'UTR|KIAA0913_uc009xrk.1_5'Flank|KIAA0913_uc001jve.2_5'Flank|KIAA0913_uc009xrl.2_5'Flank|KIAA0913_uc001jvf.2_5'Flank	NM_203298	NP_976043	Q96BP2	CHCH1_HUMAN	coiled-coil-helix-coiled-coil-helix domain	84						nucleus					0	Prostate(51;0.0112)					CAGGAAGCCCGAAAGATGAGA	0.378		NaN											0	0	0	1	0	58	71									
IFIT2	3433	broad.mit.edu	37	10	91066854	91066854	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:91066854C>T	uc009xts.2	+	2	1316	c.1141C>T	c.(1141-1143)CAG>TAG	p.Q381*	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	381	TPR 6.				negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				TGGCAACTTTCAGCTGTACCA	0.403		NaN											0	0	0	1	0	74	41									
C10orf129	142827	broad.mit.edu	37	10	96967005	96967005	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:96967005G>C	uc001kke.2	+	4	569	c.444G>C	c.(442-444)AAG>AAC	p.K148N	C10orf129_uc009xuu.1_Missense_Mutation_p.K58N	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	acyl-coenzyme A synthetase ACSM6, mitochondrial	148					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGACTGCCAAGAAAATTCGCT	0.463		NaN											0	0	0	1	0	76	59									
PPRC1	23082	broad.mit.edu	37	10	103898696	103898696	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:103898696G>A	uc001kum.2	+	4	589	c.550G>A	c.(550-552)GAC>AAC	p.D184N	PPRC1_uc001kun.2_Missense_Mutation_p.D64N|PPRC1_uc010qqj.1_Missense_Mutation_p.D184N|PPRC1_uc009xxa.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CACCCCAGTTGACCCACTGGG	0.562		NaN											0	0	0	1	0	67	55									
PPRC1	23082	broad.mit.edu	37	10	103899460	103899460	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:103899460G>C	uc001kum.2	+	5	1234	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	PPRC1_uc001kun.2_Missense_Mutation_p.E279Q|PPRC1_uc010qqj.1_Missense_Mutation_p.E399Q|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTCAGAGACAGAGGCTGCTGT	0.562		NaN											0	0	0	1	0	137	152									
SLK	9748	broad.mit.edu	37	10	105768064	105768064	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:105768064G>C	uc001kxo.1	+	12	2768	c.2734G>C	c.(2734-2736)GAG>CAG	p.E912Q	SLK_uc001kxp.1_Missense_Mutation_p.E912Q	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	912	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity	p.E912*(1)		ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGGAGAACAAGAGAAAGAGTT	0.363		NaN											0	0	0	1	0	29	85									
SORCS1	114815	broad.mit.edu	37	10	108412274	108412274	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:108412274C>T	uc001kym.2	-	18	2349	c.2341G>A	c.(2341-2343)GTA>ATA	p.V781I	SORCS1_uc001kyl.2_Missense_Mutation_p.V781I|SORCS1_uc009xxs.2_Missense_Mutation_p.V781I|SORCS1_uc001kyn.1_Missense_Mutation_p.V781I|SORCS1_uc001kyo.2_Missense_Mutation_p.V781I	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	781	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGTTCCCTTACGCCATCAGTG	0.493		NaN											0	0	0	1	0	32	95									
DCLRE1A	9937	broad.mit.edu	37	10	115607068	115607068	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:115607068G>A	uc001law.2	-	3	3070	c.2152C>T	c.(2152-2154)CAG>TAG	p.Q718*		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	718					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		ACGCCATACTGAAAGGCATCA	0.378		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	1	0	47	53									
VWA2	340706	broad.mit.edu	37	10	116045895	116045895	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:116045895G>C	uc001lbl.1	+	11	1516	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	VWA2_uc001lbk.1_Missense_Mutation_p.E399Q|VWA2_uc009xyf.1_Missense_Mutation_p.E95Q	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	399	VWFA 2.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		GCCTGTGGGGGAGTACCAGGA	0.682		NaN											0	0	0	1	0	67	136									
ATRNL1	26033	broad.mit.edu	37	10	117045884	117045884	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:117045884G>A	uc001lcg.2	+	15	2778	c.2392G>A	c.(2392-2394)GAA>AAA	p.E798K		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	798	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGTTCTGGATGAAATACAGAA	0.269		NaN											0	0	0	1	0	35	71									
ADAM12	8038	broad.mit.edu	37	10	127824155	127824155	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:127824155G>A	uc001ljk.2	-	5	836	c.423C>T	c.(421-423)CTC>CTT	p.L141L	ADAM12_uc010qul.1_Silent_p.L138L|ADAM12_uc001ljm.2_Silent_p.L141L|ADAM12_uc001ljn.2_Silent_p.L138L|ADAM12_uc001ljl.3_Silent_p.L138L	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	141					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CCACTTACCTGAGACCAGAAC	0.512		NaN											0	0	0	1	0	32	67									
C10orf90	118611	broad.mit.edu	37	10	128192934	128192934	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:128192934G>C	uc001ljq.2	-	3	956	c.835C>G	c.(835-837)CAA>GAA	p.Q279E	C10orf90_uc001ljp.2_Missense_Mutation_p.Q232E|C10orf90_uc010qum.1_Missense_Mutation_p.Q376E|C10orf90_uc009yao.2_Missense_Mutation_p.Q376E|C10orf90_uc001ljs.1_Missense_Mutation_p.Q232E	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	279										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		CTGGCAATTTGAGGTGGCTCA	0.502		NaN									OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	76	144									
MKI67	4288	broad.mit.edu	37	10	129902126	129902126	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:129902126C>G	uc001lke.2	-	13	8173	c.7978G>C	c.(7978-7980)GAA>CAA	p.E2660Q	MKI67_uc001lkf.2_Missense_Mutation_p.E2300Q|MKI67_uc009yav.1_Missense_Mutation_p.E2235Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1810Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2660	14.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTGCTGGGTTCCTCTTCTACT	0.517		NaN											0	0	0	1	0	83	70									
MKI67	4288	broad.mit.edu	37	10	129906114	129906114	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:129906114C>G	uc001lke.2	-	13	4185	c.3990G>C	c.(3988-3990)AAG>AAC	p.K1330N	MKI67_uc001lkf.2_Missense_Mutation_p.K970N|MKI67_uc009yav.1_Missense_Mutation_p.K905N|MKI67_uc009yaw.1_Missense_Mutation_p.K480N	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1330	16 X 122 AA approximate repeats.|3.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTGGCCGTCTCTTGCTGCCGG	0.502		NaN											0	0	0	1	0	123	124									
KNDC1	85442	broad.mit.edu	37	10	135003134	135003134	+	Missense_Mutation	SNP	G	G	C	rs143362573		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:135003134G>C	uc001llz.1	+	8	1475	c.1474G>C	c.(1474-1476)GAG>CAG	p.E492Q	KNDC1_uc001lma.1_Missense_Mutation_p.E427Q	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	492	KIND 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCTGGTTGCTGAGGACGGGGC	0.672		NaN											0	0	0	1	0	31	25									
OR52I1	390037	broad.mit.edu	37	11	4615695	4615695	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:4615695C>G	uc010qyi.1	+	1	427	c.427C>G	c.(427-429)CAA>GAA	p.Q143E		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	143	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCACGCCTCAAGTGATGCT	0.507		NaN											0	0	0	1	0	53	10									
OR52A4	390053	broad.mit.edu	37	11	5142104	5142104	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:5142104C>T	uc001lzz.1	-	1	705	c.705G>A	c.(703-705)CTG>CTA	p.L235L		NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GTGCCTCTTTCAGAGGCAAGT	0.358		NaN											0	0	0	1	0	43	5									
IPO7	10527	broad.mit.edu	37	11	9455272	9455272	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:9455272C>G	uc001mho.2	+	18	2095	c.1953C>G	c.(1951-1953)TTC>TTG	p.F651L		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	651					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTTTAGAATTCTATGAGGAGA	0.383		NaN											0	0	0	1	0	59	6									
EIF3M	10480	broad.mit.edu	37	11	32610646	32610646	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:32610646G>A	uc001mtu.2	+	4	446	c.403G>A	c.(403-405)GGG>AGG	p.G135R	EIF3M_uc010ref.1_Intron	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	135						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					AGCATCTTGTGGGGCCATCCA	0.383		NaN											0	0	0	1	0	33	80									
FBXO3	26273	broad.mit.edu	37	11	33763508	33763508	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:33763508C>G	uc001muz.2	-	11	1390	c.1362G>C	c.(1360-1362)CGG>CGC	p.R454R	FBXO3_uc010rej.1_Silent_p.R141R|FBXO3_uc001muy.2_Silent_p.R341R|FBXO3_uc009ykb.2_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	454	Poly-Arg.				proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AGACTCTCCTCCGTCTCTCCT	0.368		NaN											0	0	0	1	0	58	11									
LRP4	4038	broad.mit.edu	37	11	46916251	46916251	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:46916251G>A	uc001ndn.3	-	12	1575	c.1429C>T	c.(1429-1431)CAC>TAC	p.H477Y		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	477	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TCGCGGCGGTGGTGGAAATCA	0.582		NaN											0	0	0	1	0	81	9									
SLC43A1	8501	broad.mit.edu	37	11	57256845	57256845	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:57256845G>C	uc001nkk.2	-	12	1332	c.1214C>G	c.(1213-1215)TCC>TGC	p.S405C	SLC43A1_uc001nkl.2_Missense_Mutation_p.S405C	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	405					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						TGGTCTGATGGATTTGGTAGC	0.577		NaN											0	0	0	1	0	44	130									
ASRGL1	80150	broad.mit.edu	37	11	62159721	62159721	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62159721G>C	uc001nte.3	+	7	1176	c.892G>C	c.(892-894)GAT>CAT	p.D298H	ASRGL1_uc001ntf.3_Missense_Mutation_p.D298H|ASRGL1_uc001ntg.3_Missense_Mutation_p.D170H	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	298					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	CTTCGGAATTGATCCTGACGA	0.527		NaN									OREG0021023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	29	60									
INTS5	80789	broad.mit.edu	37	11	62414897	62414897	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62414897G>A	uc001nud.2	-	2	2708	c.2655C>T	c.(2653-2655)CTC>CTT	p.L885L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	885					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AATGGCCCAAGAGGGCGGCCA	0.642		NaN											0	0	0	1	0	32	72									
INTS5	80789	broad.mit.edu	37	11	62416485	62416485	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62416485G>C	uc001nud.2	-	2	1120	c.1067C>G	c.(1066-1068)TCT>TGT	p.S356C	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	356					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AAGCTCTCCAGAGACAGTGCC	0.607		NaN											0	0	0	1	0	43	96									
METTL12	751071	broad.mit.edu	37	11	62434355	62434355	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62434355G>T	uc001nug.1	+	3	814	c.555G>T	c.(553-555)TTG>TTT	p.L185F	C11orf48_uc001nue.2_Intron|C11orf48_uc001nuf.2_Intron|METTL12_uc001nuh.2_3'UTR|METTL12_uc010rmc.1_RNA	NM_001043229	NP_001036694	A8MUP2	MTL12_HUMAN	methyltransferase like 12 precursor	185						mitochondrion	methyltransferase activity				0						CAGAATGCTTGAGGGTTCTAA	0.547		NaN											1	0	5.26018e-13	1	5.41022e-13	21	28									
FKBP2	2286	broad.mit.edu	37	11	64011466	64011466	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:64011466G>C	uc001nyy.2	+	6	590	c.394G>C	c.(394-396)GAG>CAG	p.E132Q	FKBP2_uc010rnh.1_Missense_Mutation_p.E132Q|FKBP2_uc001nyz.2_Missense_Mutation_p.E132Q	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	132	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						GTTCGAGGTGGAGCTGCTCAA	0.572		NaN											0	0	0	1	0	52	118									
GPR137	56834	broad.mit.edu	37	11	64054470	64054470	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:64054470G>C	uc001nzg.1	+	3	699	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Missense_Mutation_p.E137Q|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Missense_Mutation_p.E189Q|GPR137_uc001nze.1_Missense_Mutation_p.E131Q|GPR137_uc001nzf.2_Missense_Mutation_p.E131Q|GPR137_uc001nzh.1_Missense_Mutation_p.E131Q|GPR137_uc001nzi.2_Missense_Mutation_p.E131Q|GPR137_uc010rnj.1_Missense_Mutation_p.E131Q	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	131	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						GCGTCGGCCGGAGATGAGCCG	0.572		NaN											0	0	0	1	0	10	22									
ATG2A	23130	broad.mit.edu	37	11	64662883	64662883	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:64662883G>T	uc001obx.2	-	40	5574	c.5459C>A	c.(5458-5460)TCC>TAC	p.S1820Y	uc009ypx.2_5'Flank|ATG2A_uc001obw.2_Missense_Mutation_p.S585Y	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1820							protein binding			ovary(1)|central_nervous_system(1)	2						GGCTGCCGGGGACAGGATGTC	0.701		NaN											1	0	1.26484e-09	1	1.28796e-09	7	9									
PACS1	55690	broad.mit.edu	37	11	65961019	65961019	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:65961019C>G	uc001oha.1	+	2	553	c.419C>G	c.(418-420)TCA>TGA	p.S140*	PACS1_uc001ogz.1_Nonsense_Mutation_p.S140*	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	140					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						GATCTTAACTCAGTGGTCATC	0.488		NaN											0	0	0	1	0	21	96									
GPR152	390212	broad.mit.edu	37	11	67220174	67220174	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:67220174C>T	uc001olm.2	-	1	27	c.22G>A	c.(22-24)GAC>AAC	p.D8N	uc009yrw.1_Intron|CABP4_uc001oln.2_Intron|CABP4_uc001olo.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	8	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GCACCCAGGTCAGCTTCCATG	0.602		NaN											0	0	0	1	0	59	36									
UNC93B1	81622	broad.mit.edu	37	11	67759316	67759316	+	Missense_Mutation	SNP	C	C	T	rs4014596		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:67759316C>T	uc001omw.1	-	12	1575	c.1495G>A	c.(1495-1497)GTG>ATG	p.V499M		NM_030930	NP_112192	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1	499	Helical; (Potential).				innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome					0						ACCAGCAGCACCGCCAGCTTA	0.741		NaN											0	0	0	1	0	3	28									
SUV420H1	51111	broad.mit.edu	37	11	67957499	67957499	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:67957499C>G	uc001onm.1	-	2	301	c.45G>C	c.(43-45)AGG>AGC	p.R15S	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_5'UTR|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.R15S|SUV420H1_uc001onp.2_Missense_Mutation_p.R15S|SUV420H1_uc010rqa.1_Missense_Mutation_p.R15S|SUV420H1_uc001onq.2_Missense_Mutation_p.R15S	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CTCCATTTCTCCTGCCATTCA	0.473		NaN											0	0	0	1	0	278	508									
CTTN	2017	broad.mit.edu	37	11	70265929	70265929	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:70265929C>G	uc001opv.3	+	9	852	c.646C>G	c.(646-648)CAA>GAA	p.Q216E	CTTN_uc001opu.2_Missense_Mutation_p.Q216E|CTTN_uc001opw.3_Missense_Mutation_p.Q216E|CTTN_uc010rqm.1_5'Flank|CTTN_uc001opx.2_5'Flank	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	216	Cortactin 4.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CTTTGAGTATCAAGGCAAAAC	0.473		NaN											0	0	0	1	0	137	35									
RAB38	23682	broad.mit.edu	37	11	87908415	87908415	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:87908415G>C	uc001pcj.1	-	1	185	c.138C>G	c.(136-138)TTC>TTG	p.F46L	hsa-mir-3166|MI0014196_5'Flank	NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	46	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCTTGAGCGCGAAGTCCACGC	0.637		NaN											0	0	0	1	0	32	9									
ATM	472	broad.mit.edu	37	11	108106537	108106537	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:108106537G>C	uc001pkb.1	+	5	857	c.472G>C	c.(472-474)GAA>CAA	p.E158Q	ATM_uc009yxr.1_Missense_Mutation_p.E158Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	158					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATACTGGTGTGAAATATCTCA	0.363		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	1	0	64	21									
POU2AF1	5450	broad.mit.edu	37	11	111225125	111225125	+	Missense_Mutation	SNP	G	G	C	rs149278202		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:111225125G>C	uc001plg.3	-	5	887	c.632C>G	c.(631-633)TCT>TGT	p.S211C		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	211					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		CTCTGGGATAGAGATGGGGAG	0.622		NaN	T	BCL6	NHL								0	0	0	1	0	35	12									
FDXACB1	91893	broad.mit.edu	37	11	111747287	111747287	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:111747287G>C	uc001pmc.3	-	4	907	c.610C>G	c.(610-612)CAA>GAA	p.Q204E	ALG9_uc010rwo.1_5'UTR|FDXACB1_uc009yyi.2_Missense_Mutation_p.Q55E|C11orf1_uc001pmd.2_5'Flank	NM_138378	NP_612387	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain	204					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0						ATTCTGGGTTGAGAACCTTCA	0.413		NaN											0	0	0	1	0	52	19									
TTC36	143941	broad.mit.edu	37	11	118399332	118399332	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:118399332C>G	uc001ptg.1	+	2	133	c.133C>G	c.(133-135)CAA>GAA	p.Q45E	TTC36_uc010ryb.1_RNA|TTC36_uc010ryc.1_Intron|TMEM25_uc010ryd.1_5'Flank|TMEM25_uc001ptk.3_5'Flank|TMEM25_uc010rye.1_5'Flank|TMEM25_uc001pth.2_5'Flank|TMEM25_uc009zad.2_5'Flank|TMEM25_uc001pti.2_5'Flank|TMEM25_uc010ryf.1_5'Flank|TMEM25_uc001ptl.2_5'Flank|TMEM25_uc001ptm.2_5'Flank	NM_001080441	NP_001073910	A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	45							binding				0						AGTTTTCCCTCAAGCACAGCT	0.572		NaN											0	0	0	1	0	56	10									
GLB1L3	112937	broad.mit.edu	37	11	134183857	134183857	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:134183857C>T	uc009zdf.2	+	17	1962	c.1602C>T	c.(1600-1602)ATC>ATT	p.I534I	GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	534					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CTGTCAGCATCAATAACTCTT	0.483		NaN											0	0	0	1	0	27	6									
AKAP3	10566	broad.mit.edu	37	12	4724985	4724985	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:4724985C>T	uc001qnb.3	-	5	2711	c.2482G>A	c.(2482-2484)GAG>AAG	p.E828K		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	828					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						CGCTCCTTCTCATAGCGCAGC	0.562		NaN											0	0	0	1	0	101	142									
KCNA5	3741	broad.mit.edu	37	12	5155043	5155043	+	Missense_Mutation	SNP	G	G	A	rs139805781	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:5155043G>A	uc001qni.2	+	1	1959	c.1730G>A	c.(1729-1731)CGA>CAA	p.R577Q		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	577						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GACAGTGCCCGAAGGGGCAGC	0.642		NaN											0	0	0	1	0	25	33									
PHC1	1911	broad.mit.edu	37	12	9074235	9074235	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:9074235C>G	uc001qvd.2	+	5	501	c.345C>G	c.(343-345)AGC>AGG	p.S115R	PHC1_uc001qvc.1_Missense_Mutation_p.S78R|PHC1_uc010sgn.1_Missense_Mutation_p.S115R|PHC1_uc001qve.2_Missense_Mutation_p.S115R	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	115					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						AGCTCATCAGCCGATCCCAGA	0.557		NaN											0	0	0	1	0	28	29									
PZP	5858	broad.mit.edu	37	12	9303317	9303317	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:9303317G>A	uc001qvl.2	-	34	4336	c.4307C>T	c.(4306-4308)TCC>TTC	p.S1436F	PZP_uc009zgl.2_Missense_Mutation_p.S1222F	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AACCATGAAGGAAAAACTTAG	0.383		NaN											0	0	0	1	0	34	41									
PRR4	11272	broad.mit.edu	37	12	10999683	10999683	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:10999683G>A	uc001qyz.3	-	3	423	c.384C>T	c.(382-384)CCC>CCT	p.P128P	PRR4_uc009zhp.2_Silent_p.P141P|PRH1_uc001qzb.3_RNA|PRR4_uc001qza.3_RNA	NM_007244	NP_009175	Q16378	PROL4_HUMAN	proline rich 4 (lacrimal) isoform 2	128					visual perception	extracellular space					0						GTTGCTCCTGGGGATGTCTTG	0.463		NaN											0	0	0	1	0	70	82									
TAS2R50	259296	broad.mit.edu	37	12	11138715	11138715	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:11138715C>T	uc001qzl.2	-	1	797	c.745G>A	c.(745-747)GTT>ATT	p.V249I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	249	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						GGACTCCAAACCGAAACGATT	0.438		NaN											0	0	0	1	0	40	58									
CDKN1B	1027	broad.mit.edu	37	12	12870793	12870793	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:12870793C>G	uc001rat.2	+	1	492	c.20C>G	c.(19-21)TCT>TGT	p.S7C		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	7					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		GTGCGAGTGTCTAACGGGAGC	0.612		NaN							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				0	0	0	1	0	61	85									
CDKN1B	1027	broad.mit.edu	37	12	12871765	12871765	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:12871765C>G	uc001rat.2	+	2	954	c.482C>G	c.(481-483)TCT>TGT	p.S161C		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	161	Nuclear localization signal (Potential).			S->A: No change in PKB/AKT1-mediated phosphorylation.	autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		TTAGATTCTTCTACTCAAAAC	0.438		NaN							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				0	0	0	1	0	77	95									
SOX5	6660	broad.mit.edu	37	12	23728769	23728769	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:23728769C>T	uc001rfw.2	-	10	1270	c.1168G>A	c.(1168-1170)GAA>AAA	p.E390K	SOX5_uc001rfx.2_Missense_Mutation_p.E377K|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Missense_Mutation_p.E4K|SOX5_uc010siv.1_Missense_Mutation_p.E377K|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E342K	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	390					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TGTGCCACTTCATCCTGCAAT	0.443		NaN											0	0	0	1	0	40	52									
SOX5	6660	broad.mit.edu	37	12	23998926	23998926	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:23998926C>G	uc001rfw.2	-	3	574	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	SOX5_uc001rfx.2_Missense_Mutation_p.E145Q|SOX5_uc001rfy.2_Missense_Mutation_p.E145Q|SOX5_uc010siv.1_Missense_Mutation_p.E145Q|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E110Q|SOX5_uc001rga.2_Missense_Mutation_p.E123Q	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	158					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CCTTCCGGCTCGTTTTTGATG	0.408		NaN											0	0	0	1	0	32	62									
PRPF40B	25766	broad.mit.edu	37	12	50029643	50029643	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:50029643C>T	uc001rur.1	+	14	1291	c.1227C>T	c.(1225-1227)CTC>CTT	p.L409L	PRPF40B_uc001rup.1_Silent_p.L431L|PRPF40B_uc001ruq.1_Silent_p.L403L|PRPF40B_uc001rus.1_Silent_p.L352L	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	409					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CCAAGCAGCTCCGGCGCCGCA	0.602		NaN											0	0	0	1	0	43	44									
SCN8A	6334	broad.mit.edu	37	12	52100287	52100287	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:52100287C>T	uc001ryw.2	+	11	1601	c.1423C>T	c.(1423-1425)CGG>TGG	p.R475W	SCN8A_uc010snl.1_Missense_Mutation_p.R340W|SCN8A_uc001ryx.1_Missense_Mutation_p.R340W|SCN8A_uc001ryz.1_Missense_Mutation_p.R340W|SCN8A_uc001ryy.2_Missense_Mutation_p.R340W	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	475					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGGCTCCCCTCGGAGCTCTTC	0.502		NaN											0	0	0	1	0	12	10									
EIF4B	1975	broad.mit.edu	37	12	53412671	53412671	+	Silent	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:53412671C>A	uc001sbh.3	+	3	447	c.241C>A	c.(241-243)CGG>AGG	p.R81R	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Silent_p.R81R|EIF4B_uc010snv.1_Silent_p.R81R|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	81					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						ACGGGCTGCTCGGGAACCCAA	0.512		NaN											1	0	6.09941e-20	1	6.34794e-20	52	113									
SMARCC2	6601	broad.mit.edu	37	12	56575311	56575311	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:56575311G>C	uc001skb.2	-	10	1017	c.911C>G	c.(910-912)TCT>TGT	p.S304C	SMARCC2_uc001skd.2_Missense_Mutation_p.S304C|SMARCC2_uc001ska.2_Missense_Mutation_p.S304C|SMARCC2_uc001skc.2_Missense_Mutation_p.S304C|SMARCC2_uc010sqf.1_Missense_Mutation_p.S193C	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	304					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGTGAAGGAGAGGGGGAGCG	0.507		NaN											0	0	0	1	0	29	45									
BAZ2A	11176	broad.mit.edu	37	12	56996518	56996518	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:56996518C>A	uc001slq.1	-	19	3603	c.3409G>T	c.(3409-3411)GAA>TAA	p.E1137*	BAZ2A_uc001slp.1_Nonsense_Mutation_p.E1135*|BAZ2A_uc001slo.1_5'Flank|BAZ2A_uc009zov.1_Nonsense_Mutation_p.E107*|BAZ2A_uc009zow.1_Nonsense_Mutation_p.E1105*	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1137					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TCTGTTCCTTCTACAAAGATA	0.493		NaN											1	0	3.6726e-16	1	3.79647e-16	20	33									
SRGAP1	57522	broad.mit.edu	37	12	64472798	64472798	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:64472798G>C	uc010ssp.1	+	9	1281	c.1225G>C	c.(1225-1227)GAA>CAA	p.E409Q	SRGAP1_uc001srt.2_Missense_Mutation_p.E409Q|SRGAP1_uc001srv.2_Missense_Mutation_p.E369Q	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	409					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TCGTTCCACAGAATCAGTGAA	0.468		NaN											0	0	0	1	0	37	44									
ZDHHC17	23390	broad.mit.edu	37	12	77239552	77239552	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:77239552C>T	uc001syk.1	+	13	1556	c.1393C>T	c.(1393-1395)CAT>TAT	p.H465Y		NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	465	Cytoplasmic (Potential).|DHHC-type.				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						AAAATTTGATCATCATTGCCC	0.348		NaN											0	0	0	1	0	102	113									
SLC6A15	55117	broad.mit.edu	37	12	85285836	85285836	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:85285836C>G	uc001szv.2	-	2	557	c.64G>C	c.(64-66)GAC>CAC	p.D22H	SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.D22H	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	22	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GAAAGAAGGTCTTTGACAGAC	0.353		NaN											0	0	0	1	0	79	113									
AMDHD1	144193	broad.mit.edu	37	12	96354209	96354209	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:96354209C>T	uc001tel.1	+	5	727	c.621C>T	c.(619-621)ATC>ATT	p.I207I	AMDHD1_uc009zth.1_Silent_p.I98I	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	207					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						CTGATGACATCATCAATAACC	0.403		NaN											0	0	0	1	0	17	38									
TXNRD1	7296	broad.mit.edu	37	12	104609593	104609593	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:104609593G>A	uc010swk.1	+	1	35	c.13G>A	c.(13-15)GAG>AAG	p.E5K	TXNRD1_uc001tkm.1_Intron	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	5					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GGGCTGCGCCGAGGGCAAGGC	0.721		NaN									OREG0022069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	2									
NUAK1	9891	broad.mit.edu	37	12	106461446	106461446	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:106461446C>G	uc001tlj.1	-	7	2500	c.1120G>C	c.(1120-1122)GAG>CAG	p.E374Q		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	374							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						AAGTCATTCTCTTTCTTGGAT	0.542		NaN											0	0	0	1	0	42	58									
ATXN2	6311	broad.mit.edu	37	12	111926344	111926344	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:111926344G>C	uc001tsj.2	-	15	2818	c.2656C>G	c.(2656-2658)CAG>GAG	p.Q886E	ATXN2_uc001tsh.2_Missense_Mutation_p.Q621E|ATXN2_uc001tsi.2_Missense_Mutation_p.Q597E|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.Q72E	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	886					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CTGGAAGTCTGAACCCCTTGG	0.498		NaN											0	0	0	1	0	33	64									
NAA25	80018	broad.mit.edu	37	12	112530905	112530905	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:112530905G>A	uc001ttm.2	-	2	114	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.Q4*|NAA25_uc009zwa.1_Nonsense_Mutation_p.Q32*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	32	TPR 1.					cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TCTGCTTGCTGAATTGCCATT	0.308		NaN											0	0	0	1	0	54	70									
TBX5	6910	broad.mit.edu	37	12	114793425	114793425	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:114793425G>C	uc001tvo.2	-	9	1964	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	TBX5_uc001tvp.2_Missense_Mutation_p.S490C|TBX5_uc001tvq.2_Missense_Mutation_p.S440C	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	490					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CACGCCATGAGAGTAGAGGAA	0.612		NaN											0	0	0	1	0	20	48									
FBXO21	23014	broad.mit.edu	37	12	117583954	117583954	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:117583954C>G	uc001twk.2	-	12	1864	c.1825G>C	c.(1825-1827)GAG>CAG	p.E609Q	FBXO21_uc001twj.2_Missense_Mutation_p.E602Q|FBXO21_uc009zwq.2_Missense_Mutation_p.E542Q	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	609					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TAGACAAACTCCAGATCTTCT	0.453		NaN											0	0	0	1	0	48	86									
GCN1L1	10985	broad.mit.edu	37	12	120575576	120575576	+	Missense_Mutation	SNP	C	C	T	rs146550123	by1000genomes	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:120575576C>T	uc001txo.2	-	49	6449	c.6436G>A	c.(6436-6438)GAC>AAC	p.D2146N		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2146					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCCCTGTGTCATCCTCTACG	0.582		NaN											0	0	0	1	0	23	21									
HNF1A	6927	broad.mit.edu	37	12	121426650	121426650	+	Missense_Mutation	SNP	G	G	A	rs139016696	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:121426650G>A	uc001tzg.2	+	2	364	c.341G>A	c.(340-342)CGT>CAT	p.R114H	HNF1A_uc001tze.1_Missense_Mutation_p.R114H|HNF1A_uc001tzf.2_Missense_Mutation_p.R114H|HNF1A_uc010szn.1_Missense_Mutation_p.R114H	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	114					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GACCCGTGGCGTGTGGCGAAG	0.627		NaN							Hepatic_Adenoma_Familial_Clustering_of				0	0	0	1	0	29	42									
SBNO1	55206	broad.mit.edu	37	12	123798237	123798237	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:123798237C>G	uc010tap.1	-	23	3150	c.3150G>C	c.(3148-3150)ATG>ATC	p.M1050I	SBNO1_uc010tao.1_Missense_Mutation_p.M1049I|SBNO1_uc010taq.1_Missense_Mutation_p.M1I|SBNO1_uc001ues.1_Missense_Mutation_p.M1I	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1050							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CAATGGATTTCATGACAATTT	0.333		NaN											0	0	0	1	0	17	19									
DNAH10	196385	broad.mit.edu	37	12	124398990	124398990	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:124398990C>T	uc001uft.3	+	60	10138	c.10113C>T	c.(10111-10113)GAC>GAT	p.D3371D		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3371					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGTTCCGTGACGAGATGGTCA	0.597		NaN											0	0	0	1	0	48	55									
RIMBP2	23504	broad.mit.edu	37	12	130926567	130926567	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:130926567C>A	uc001uil.2	-	8	1443	c.1279G>T	c.(1279-1281)GAG>TAG	p.E427*	RIMBP2_uc001uim.2_Nonsense_Mutation_p.E335*|RIMBP2_uc001uin.1_Nonsense_Mutation_p.E86*	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	427	Fibronectin type-III 2.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGAACTCCTCCTCGTTGAGG	0.572		NaN											1	0	2.66076e-39	1	2.8366e-39	57	67									
MPHOSPH8	54737	broad.mit.edu	37	13	20222578	20222578	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:20222578G>C	uc001umh.2	+	4	1244	c.1235G>C	c.(1234-1236)AGA>ACA	p.R412T	MPHOSPH8_uc001umg.2_Missense_Mutation_p.R412T|MPHOSPH8_uc001umi.2_Missense_Mutation_p.R109T	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	412					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GAAACCAAAAGAAATGAATCC	0.318		NaN											0	0	0	1	0	6	10									
SLC7A1	6541	broad.mit.edu	37	13	30091761	30091761	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:30091761C>G	uc001uso.2	-	10	1846	c.1459G>C	c.(1459-1461)GAG>CAG	p.E487Q		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	487	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TTGGAAGGCTCCATGTTTTTG	0.463		NaN											0	0	0	1	0	82	79									
C13orf36	400120	broad.mit.edu	37	13	37269507	37269507	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:37269507C>T	uc001uvt.3	+	2	738	c.292C>T	c.(292-294)CAG>TAG	p.Q98*		NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120	98						integral to membrane				skin(1)	1						CATTTCCTCTCAGAGGTCCAC	0.483		NaN											0	0	0	1	0	35	37									
FREM2	341640	broad.mit.edu	37	13	39432167	39432167	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:39432167C>G	uc001uwv.2	+	13	7521	c.7212C>G	c.(7210-7212)ATC>ATG	p.I2404M	FREM2_uc001uww.2_Missense_Mutation_p.I490M	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2404	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCATCTGTATCACAGTGAGTA	0.353		NaN											0	0	0	1	0	43	88									
RB1	5925	broad.mit.edu	37	13	49050910	49050910	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:49050910G>T	uc001vcb.2	+	25	2760	c.2594G>T	c.(2593-2595)GGA>GTA	p.G865V		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	865	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGTGCTGAAGGAAGCAACCCT	0.383		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			1	0	6.81593e-30	1	7.21618e-30	46	78									
MYCBP2	23077	broad.mit.edu	37	13	77642919	77642919	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:77642919G>C	uc001vkf.2	-	71	11929	c.11838C>G	c.(11836-11838)GTC>GTG	p.V3946V	MYCBP2_uc010aev.2_Silent_p.V3350V|MYCBP2_uc001vke.2_Silent_p.V563V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3946					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATTCTTCACGGACTCTGGTAG	0.398		NaN											0	0	0	1	0	59	56									
EDNRB	1910	broad.mit.edu	37	13	78474013	78474013	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:78474013C>G	uc001vko.2	-	6	1433	c.1175G>C	c.(1174-1176)AGA>ACA	p.R392T	EDNRB_uc001vkq.1_Missense_Mutation_p.R392T|uc001vkn.1_Intron|EDNRB_uc010aez.1_Missense_Mutation_p.R392T|EDNRB_uc001vkp.1_Missense_Mutation_p.R475T	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	392	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GTTTTTGAATCTTTTGCTCAC	0.338		NaN											0	0	0	1	0	39	36									
SLITRK5	26050	broad.mit.edu	37	13	88328479	88328479	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:88328479C>G	uc001vln.2	+	2	1055	c.836C>G	c.(835-837)TCC>TGC	p.S279C	SLITRK5_uc010tic.1_Missense_Mutation_p.S38C	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	279	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GACGAGGTATCCAAGCAGGAA	0.542		NaN											0	0	0	1	0	32	77									
TEP1	7011	broad.mit.edu	37	14	20876254	20876254	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:20876254G>A	uc001vxe.2	-	2	385	c.345C>T	c.(343-345)CTC>CTT	p.L115L	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L115L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	115	TEP1 N-terminal 4.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TTAGACTAGAGAGGGTGGCCA	0.512		NaN											0	0	0	1	0	67	110									
SUPT16H	11198	broad.mit.edu	37	14	21822642	21822642	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:21822642C>G	uc001wao.2	-	23	3057	c.2718G>C	c.(2716-2718)ATG>ATC	p.M906I	SUPT16H_uc001wan.2_Missense_Mutation_p.M50I	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	906					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CAATGGTCTTCATGATTTTAG	0.463		NaN											0	0	0	1	0	46	58									
CMTM5	116173	broad.mit.edu	37	14	23847933	23847933	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:23847933C>T	uc010akm.2	+	3	779	c.335C>T	c.(334-336)TCA>TTA	p.S112L	CMTM5_uc001wjs.2_Intron|CMTM5_uc001wjt.2_Intron|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	112	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CTCTCCCACTCAGCAAAGGTC	0.632		NaN											0	0	0	1	0	33	59									
CTSG	1511	broad.mit.edu	37	14	25044531	25044531	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:25044531C>G	uc001wpq.2	-	2	180	c.143G>C	c.(142-144)AGA>ACA	p.R48T		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	48	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CCCTCCACATCTGCTCTGACC	0.592		NaN											0	0	0	1	0	114	136									
BAZ1A	11177	broad.mit.edu	37	14	35227966	35227966	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:35227966C>G	uc001wsk.2	-	25	4898	c.4330G>C	c.(4330-4332)GAA>CAA	p.E1444Q	BAZ1A_uc001wsl.2_Missense_Mutation_p.E1412Q	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1444					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CGTACCAATTCTACAACAAGT	0.393		NaN											0	0	0	1	0	41	74									
DLGAP5	9787	broad.mit.edu	37	14	55642131	55642131	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:55642131C>T	uc001xbs.2	-	10	1451	c.1234G>A	c.(1234-1236)GAA>AAA	p.E412K	DLGAP5_uc001xbt.2_Missense_Mutation_p.E412K	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	412					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						GATGGGACTTCTTTTATTGGA	0.313		NaN											0	0	0	1	0	21	16									
C14orf105	55195	broad.mit.edu	37	14	57947337	57947337	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:57947337C>T	uc001xcy.2	-	5	774	c.631G>A	c.(631-633)GAT>AAT	p.D211N	C14orf105_uc010trl.1_Missense_Mutation_p.D210N|C14orf105_uc010trm.1_Missense_Mutation_p.D122N|C14orf105_uc010trn.1_Missense_Mutation_p.D122N|C14orf105_uc001xcz.2_Missense_Mutation_p.D210N|C14orf105_uc010aox.1_RNA|C14orf105_uc010aoy.1_Missense_Mutation_p.D132N	NM_018168	NP_060638	Q9NVL8	CN105_HUMAN	hypothetical protein LOC55195	211											0						AAGATTTCATCAGGCAACATG	0.393		NaN											0	0	0	1	0	59	89									
SYNE2	23224	broad.mit.edu	37	14	64522742	64522742	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:64522742C>T	uc001xgm.2	+	49	10055	c.9825C>T	c.(9823-9825)CTC>CTT	p.L3275L	SYNE2_uc001xgl.2_Silent_p.L3275L|SYNE2_uc010apw.1_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3275	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCACTTCCCTCGAAGCCATCA	0.408		NaN											0	0	0	1	0	44	53									
SYNE2	23224	broad.mit.edu	37	14	64593421	64593421	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:64593421G>C	uc001xgm.2	+	73	14043	c.13813G>C	c.(13813-13815)GAA>CAA	p.E4605Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E4605Q|SYNE2_uc010apy.2_Missense_Mutation_p.E990Q|SYNE2_uc010apz.1_Missense_Mutation_p.E497Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4605	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTTGCTCCTTGAATGTTTTGA	0.478		NaN											0	0	0	1	0	55	59									
SIPA1L1	26037	broad.mit.edu	37	14	72176165	72176165	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:72176165C>G	uc001xms.2	+	15	4403	c.4055C>G	c.(4054-4056)TCA>TGA	p.S1352*	SIPA1L1_uc001xmt.2_Nonsense_Mutation_p.S1331*|SIPA1L1_uc001xmu.2_Nonsense_Mutation_p.S1331*|SIPA1L1_uc001xmv.2_Nonsense_Mutation_p.S1352*|SIPA1L1_uc010ttm.1_Nonsense_Mutation_p.S806*|SIPA1L1_uc001xmw.2_Nonsense_Mutation_p.S117*	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1352	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TCACCTCGCTCAGGGCCAGGC	0.612		NaN											0	0	0	1	0	32	50									
PAPLN	89932	broad.mit.edu	37	14	73727502	73727502	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:73727502G>A	uc010ttx.1	+	16	2234	c.2071G>A	c.(2071-2073)GGG>AGG	p.G691R	PAPLN_uc001xnw.3_Missense_Mutation_p.G664R|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.G691R|PAPLN_uc010arm.2_5'UTR|PAPLN_uc010arn.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	691						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TGACAGCACCGGGGGCATGCC	0.637		NaN											0	0	0	1	0	26	19									
TGFB3	7043	broad.mit.edu	37	14	76427367	76427367	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:76427367C>G	uc001xsc.2	-	6	1835	c.979G>C	c.(979-981)GAT>CAT	p.D327H		NM_003239	NP_003230	P10600	TGFB3_HUMAN	transforming growth factor, beta 3 precursor	327					cell growth|cell-cell junction organization|detection of hypoxia|face morphogenesis|in utero embryonic development|induction of apoptosis|lung alveolus development|mammary gland development|menstrual cycle phase|negative regulation of cell proliferation|negative regulation of DNA replication|negative regulation of macrophage cytokine production|negative regulation of neuron apoptosis|odontogenesis|ossification involved in bone remodeling|palate development|platelet activation|platelet degranulation|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of collagen biosynthetic process|positive regulation of DNA replication|positive regulation of epithelial to mesenchymal transition|positive regulation of filopodium assembly|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|response to progesterone stimulus|salivary gland morphogenesis|transforming growth factor beta receptor signaling pathway	extracellular matrix|platelet alpha granule lumen	growth factor activity|identical protein binding|transforming growth factor beta binding|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0169)		CAGCCCAGATCCTGTCGGAAG	0.488		NaN											0	0	0	1	0	54	85									
TTC7B	145567	broad.mit.edu	37	14	91123528	91123528	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:91123528G>C	uc001xyp.2	-	11	1453	c.1331C>G	c.(1330-1332)TCC>TGC	p.S444C	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	444							binding			ovary(2)	2		Melanoma(154;0.222)				CCAGTGCAGGGAGCCCATGCA	0.622		NaN											0	0	0	1	0	44	76									
ATP10A	57194	broad.mit.edu	37	15	25981266	25981266	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:25981266G>A	uc010ayu.2	-	3	783	c.677C>T	c.(676-678)ACG>ATG	p.T226M		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	226	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCTGGTGAACGTCAAAGGATT	0.507		NaN											0	0	0	1	0	24	43									
GABRG3	2567	broad.mit.edu	37	15	27772741	27772741	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:27772741G>A	uc001zbg.1	+	8	1194	c.1028G>A	c.(1027-1029)TGT>TAT	p.C343Y		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	343	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TATTCCAGCTGTAGAAAACCA	0.522		NaN											0	0	0	1	0	11	15									
RAD51	5888	broad.mit.edu	37	15	41023291	41023291	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:41023291G>A	uc001zmi.3	+	10	1234	c.935G>A	c.(934-936)TGC>TAC	p.C312Y	RAD51_uc010bbw.2_Silent_p.L271L|RAD51_uc010bbx.2_Missense_Mutation_p.C313Y|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.C313Y	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	312					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		ACCAGAATCTGCAAAATCTAC	0.423		NaN						Homologous_recombination					0	0	0	1	0	50	66									
VPS18	57617	broad.mit.edu	37	15	41192994	41192994	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:41192994G>A	uc001zne.2	+	4	2317	c.1978G>A	c.(1978-1980)GAG>AAG	p.E660K		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	660	Clathrin.				endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGGGGAGACTGAGCAGGCCAT	0.637		NaN											0	0	0	1	0	94	105									
FBN1	2200	broad.mit.edu	37	15	48741027	48741027	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:48741027C>T	uc001zwx.1	-	46	5937	c.5609G>A	c.(5608-5610)GGA>GAA	p.G1870E	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1870	EGF-like 31; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATAAAAGCTTCCAACTGTGTC	0.353		NaN											0	0	0	1	0	31	36									
LEO1	123169	broad.mit.edu	37	15	52258162	52258162	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:52258162C>T	uc002abo.2	-	2	614	c.598G>A	c.(598-600)GAG>AAG	p.E200K	LEO1_uc010bfd.2_Missense_Mutation_p.E200K	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	200	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TGTTGTCTCTCATCATCGGAA	0.438		NaN											0	0	0	1	0	150	193									
TLN2	83660	broad.mit.edu	37	15	63008574	63008574	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:63008574G>C	uc002alb.3	+	20	2679	c.2679G>C	c.(2677-2679)CTG>CTC	p.L893L		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	893	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AGCAAAGGCTGAGAGAAGCTG	0.502		NaN											0	0	0	1	0	35	48									
HCN4	10021	broad.mit.edu	37	15	73615897	73615897	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:73615897G>A	uc002avp.2	-	8	3531	c.2537C>T	c.(2536-2538)CCG>CTG	p.P846L		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	846	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CACCTGGGACGGGCTGCTGGC	0.672		NaN											0	0	0	1	0	54	84									
C15orf39	56905	broad.mit.edu	37	15	75498861	75498861	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:75498861G>C	uc002azp.3	+	2	792	c.472G>C	c.(472-474)GAC>CAC	p.D158H	C15orf39_uc002azq.3_Missense_Mutation_p.D158H|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	158											0						ACTGGATGTTGACTGGACTCT	0.612		NaN											0	0	0	1	0	42	71									
NEIL1	79661	broad.mit.edu	37	15	75641328	75641328	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:75641328G>T	uc002bad.2	+	2	588	c.82G>T	c.(82-84)GAG>TAG	p.E28*	NEIL1_uc002bae.2_Nonsense_Mutation_p.E114*	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	28					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						CGGCTGCGTGGAGAAGTCCTC	0.647		NaN						BER_DNA_glycosylases					1	0	1.74807e-11	1	1.78893e-11	29	60									
SEC11A	23478	broad.mit.edu	37	15	85259297	85259297	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:85259297G>C	uc002blb.1	-	1	378	c.10C>G	c.(10-12)CTA>GTA	p.L4V	SEC11A_uc002blc.1_5'UTR	NM_014300	NP_055115	P67812	SC11A_HUMAN	SEC11-like 1	4	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	protein binding|serine-type peptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(143;0.199)			AAAAAGTCTAGAGACAGCATG	0.622		NaN											0	0	0	1	0	21	23									
AGBL1	123624	broad.mit.edu	37	15	86807733	86807733	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:86807733C>G	uc002blz.1	+	10	1273	c.1193C>G	c.(1192-1194)TCC>TGC	p.S398C	AGBL1_uc002bma.1_Missense_Mutation_p.S129C|AGBL1_uc002bmb.1_Missense_Mutation_p.S92C	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	398					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						AATGTGCAATCCAATAGTCTC	0.488		NaN											0	0	0	1	0	17	42									
BLM	641	broad.mit.edu	37	15	91341444	91341444	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:91341444G>A	uc002bpr.2	+	17	3332	c.3235G>A	c.(3235-3237)GAC>AAC	p.D1079N	BLM_uc010uqh.1_Missense_Mutation_p.D1079N|BLM_uc010uqi.1_Missense_Mutation_p.D704N|BLM_uc010bnx.2_Missense_Mutation_p.D1079N|BLM_uc002bpt.2_Missense_Mutation_p.D54N	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1079					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AGATGTGACTGACGATGTGAA	0.294		NaN	Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				0	0	0	1	0	32	32									
IGF1R	3480	broad.mit.edu	37	15	99467847	99467847	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:99467847C>T	uc002bul.2	+	13	2766	c.2716C>T	c.(2716-2718)CAG>TAG	p.Q906*	IGF1R_uc010bon.2_Nonsense_Mutation_p.Q906*|IGF1R_uc010boo.1_RNA	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	906	Extracellular (Potential).|Fibronectin type-III 3.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	AGCCCGGATTCAGGCCACATC	0.527		NaN											0	0	0	1	0	36	81									
GNPTG	84572	broad.mit.edu	37	16	1412126	1412126	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:1412126G>A	uc002clm.2	+	6	440	c.405G>A	c.(403-405)CAG>CAA	p.Q135Q		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	135						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				GGAGCCGGCAGAGCAAGGTGG	0.667		NaN											0	0	0	1	0	8	0									
TSC2	7249	broad.mit.edu	37	16	2110794	2110794	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2110794C>T	uc002con.2	+	11	1205	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W	TSC2_uc010bsd.2_Missense_Mutation_p.R367W|TSC2_uc002coo.2_Missense_Mutation_p.R367W|TSC2_uc010uvv.1_Missense_Mutation_p.R330W|TSC2_uc010uvw.1_Missense_Mutation_p.R318W|TSC2_uc002cop.2_Missense_Mutation_p.R167W	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	367	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CATCATCGAACGGCTCCTTCA	0.602		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	1	0	47	8									
CEMP1	752014	broad.mit.edu	37	16	2580759	2580759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2580759G>A	uc002cqr.2	-	1	672	c.316C>T	c.(316-318)CAG>TAG	p.Q106*	AMDHD2_uc010uwc.1_Silent_p.*595*|AMDHD2_uc010uwd.1_Silent_p.*359*	NM_001048212	NP_001041677	Q6PRD7	CEMP1_HUMAN	cementum protein 1	106						cytoplasm				skin(1)	1						GGCCTCGCCTGAGGGAGGGCC	0.632		NaN											0	0	0	1	0	17	4									
SRRM2	23524	broad.mit.edu	37	16	2814872	2814872	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2814872G>C	uc002crk.2	+	11	4892	c.4343G>C	c.(4342-4344)AGA>ACA	p.R1448T	SRRM2_uc002crj.1_Missense_Mutation_p.R1352T|SRRM2_uc002crl.1_Missense_Mutation_p.R1448T|SRRM2_uc010bsu.1_Missense_Mutation_p.R1352T	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1448	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCAGGACTTAGAGATGGGTCT	0.493		NaN											0	0	0	1	0	86	22									
SRRM2	23524	broad.mit.edu	37	16	2815072	2815072	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2815072G>C	uc002crk.2	+	11	5092	c.4543G>C	c.(4543-4545)GAA>CAA	p.E1515Q	SRRM2_uc002crj.1_Missense_Mutation_p.E1419Q|SRRM2_uc002crl.1_Missense_Mutation_p.E1515Q|SRRM2_uc010bsu.1_Missense_Mutation_p.E1419Q	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1515	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCCCCAGAGAGAAAGAAGCGG	0.522		NaN											0	0	0	1	0	135	37									
ADCY9	115	broad.mit.edu	37	16	4016668	4016668	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:4016668C>G	uc002cvx.2	-	11	3709	c.3170G>C	c.(3169-3171)GGA>GCA	p.G1057A		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1057	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						GATCACCCCTCCGCTGTCATG	0.592		NaN											0	0	0	1	0	156	35									
HMOX2	3163	broad.mit.edu	37	16	4556895	4556895	+	Splice_Site	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:4556895G>A	uc010bts.2	+	3	258	c.87_splice	c.e3-1	p.R29_splice	HMOX2_uc002cwr.3_Splice_Site_p.R29_splice|HMOX2_uc002cwq.3_Splice_Site_p.R29_splice|HMOX2_uc002cws.3_Splice_Site_p.R83_splice|HMOX2_uc010btt.2_Splice_Site_p.R29_splice|HMOX2_uc002cwt.2_Splice_Site_p.R29_splice	NM_001127206	NP_001120678	P30519	HMOX2_HUMAN	heme oxygenase (decyclizing) 2						cellular iron ion homeostasis|heme catabolic process|heme oxidation|response to hypoxia|transmembrane transport	endoplasmic reticulum membrane|microsome|plasma membrane	electron carrier activity|heme oxygenase (decyclizing) activity|metal ion binding|protein binding				0					NADH(DB00157)	TCTCTCCACAGAATGGCTGAC	0.517		NaN									OREG0023582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	112	30									
DNAH3	55567	broad.mit.edu	37	16	21136611	21136611	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:21136611G>C	uc010vbe.1	-	9	1289	c.1289C>G	c.(1288-1290)TCA>TGA	p.S430*	DNAH3_uc002die.2_Nonsense_Mutation_p.S401*	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	430	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTTTCGACTTGAGTCATAGTT	0.483		NaN											0	0	0	1	0	63	21									
TMEM159	57146	broad.mit.edu	37	16	21172532	21172532	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:21172532C>G	uc002dif.3	+	2	390	c.29C>G	c.(28-30)TCA>TGA	p.S10*	DNAH3_uc010vbe.1_5'Flank|TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Nonsense_Mutation_p.S10*|TMEM159_uc002dih.3_Nonsense_Mutation_p.S10*	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	10						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		CAGAGTATCTCAAGGGACTTG	0.438		NaN											0	0	0	1	0	29	9									
CLN3	1201	broad.mit.edu	37	16	28493700	28493700	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:28493700C>G	uc002dpo.2	-	12	1233	c.910G>C	c.(910-912)GAA>CAA	p.E304Q	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.E226Q|CLN3_uc010vcu.1_Missense_Mutation_p.E204Q|CLN3_uc002dpn.2_Missense_Mutation_p.E205Q|CLN3_uc002dpm.2_Missense_Mutation_p.E250Q|CLN3_uc010vcv.1_Missense_Mutation_p.E280Q|CLN3_uc010byd.2_Intron|CLN3_uc002dpp.2_Missense_Mutation_p.E304Q|CLN3_uc002dpt.1_Missense_Mutation_p.E204Q|CLN3_uc002dpq.1_Missense_Mutation_p.E256Q|CLN3_uc010bye.1_Missense_Mutation_p.E287Q|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.E177Q|CLN3_uc002dpu.1_Missense_Mutation_p.E202Q|CLN3_uc002dpw.1_Missense_Mutation_p.E151Q|CLN3_uc010vcw.1_Missense_Mutation_p.E250Q|CLN3_uc002dqa.2_3'UTR|CLN3_uc010vcx.1_3'UTR	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	304					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						AAGAGGAGTTCAAACTGCAAC	0.592		NaN											0	0	0	1	0	27	39									
CD19	930	broad.mit.edu	37	16	28948444	28948444	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:28948444C>T	uc002drs.2	+	8	1247	c.1185C>T	c.(1183-1185)AGC>AGT	p.S395S	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.S395S	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	395	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						GGTCCCGGAGCCCGCCGGGAG	0.692		NaN											0	0	0	1	0	4	6									
RNF40	9810	broad.mit.edu	37	16	30777495	30777495	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:30777495G>A	uc002dzq.2	+	9	1128	c.1005G>A	c.(1003-1005)CTG>CTA	p.L335L	RNF40_uc010caa.2_Silent_p.L335L|RNF40_uc010cab.2_Intron|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Silent_p.L335L|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	335	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			TTGAGATGCTGAATGCAGAGT	0.592		NaN											0	0	0	1	0	53	88									
MYLK3	91807	broad.mit.edu	37	16	46764544	46764544	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:46764544G>C	uc002eei.3	-	5	1645	c.1529C>G	c.(1528-1530)TCT>TGT	p.S510C	MYLK3_uc010vge.1_Missense_Mutation_p.S169C|MYLK3_uc002eej.1_Missense_Mutation_p.S169C	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	510					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GTAACCCGCAGAGATGGAGGT	0.612		NaN											0	0	0	1	0	72	126									
NUP93	9688	broad.mit.edu	37	16	56857669	56857669	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:56857669G>A	uc002eka.2	+	8	826	c.705G>A	c.(703-705)TTG>TTA	p.L235L	NUP93_uc002ekb.2_Silent_p.L112L|NUP93_uc010vhi.1_Silent_p.L112L	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	235					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						ACGTGTTGTTGACACCGGCAA	0.517		NaN											0	0	0	1	0	77	85									
SLC12A3	6559	broad.mit.edu	37	16	56899426	56899426	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:56899426C>G	uc010ccm.2	+	1	308	c.279C>G	c.(277-279)CTC>CTG	p.L93L	SLC12A3_uc002ekd.3_Silent_p.L93L|SLC12A3_uc010ccn.2_Silent_p.L93L	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	93	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ACTCCTTCCTCAAGGTAAGTG	0.373		NaN											0	0	0	1	0	32	38									
FBXL8	55336	broad.mit.edu	37	16	67195736	67195736	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67195736C>T	uc002erj.1	+	2	168	c.48C>T	c.(46-48)ATC>ATT	p.I16I	TRADD_uc002eri.1_5'Flank|TRADD_uc010vjb.1_5'Flank|FBXL8_uc002erk.1_Silent_p.I16I|HSF4_uc002erl.1_5'Flank|HSF4_uc002erm.1_5'Flank|HSF4_uc002ern.1_5'Flank|HSF4_uc010cec.1_5'Flank	NM_018378	NP_060848	Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	16	F-box.						protein binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		TGGCACTCATCTTCCGCCACC	0.682		NaN											0	0	0	1	0	13	17									
FBXL8	55336	broad.mit.edu	37	16	67196840	67196840	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67196840C>T	uc002erj.1	+	3	362	c.242C>T	c.(241-243)TCG>TTG	p.S81L	FBXL8_uc002erk.1_Missense_Mutation_p.S81L|HSF4_uc002erl.1_5'Flank|HSF4_uc002erm.1_5'Flank|HSF4_uc002ern.1_5'Flank|HSF4_uc010cec.1_5'Flank	NM_018378	NP_060848	Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	81							protein binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		TTTGAGCCATCGAGGAAGCCG	0.632		NaN											0	0	0	1	0	3	2									
E2F4	1874	broad.mit.edu	37	16	67228652	67228652	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67228652C>G	uc002erz.2	+	6	640	c.577C>G	c.(577-579)CTG>GTG	p.L193V		NM_001950	NP_001941	Q16254	E2F4_HUMAN	E2F transcription factor 4	193					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		CATTGAGGTTCTGCTGGTGAA	0.542		NaN											0	0	0	1	0	63	58									
FAM65A	79567	broad.mit.edu	37	16	67575861	67575861	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67575861C>G	uc010vjp.1	+	13	1328	c.1232C>G	c.(1231-1233)TCA>TGA	p.S411*	FAM65A_uc010cei.1_Nonsense_Mutation_p.S233*|FAM65A_uc002eth.2_Nonsense_Mutation_p.S391*|FAM65A_uc010cej.2_Nonsense_Mutation_p.S394*|FAM65A_uc002eti.1_Nonsense_Mutation_p.S354*|FAM65A_uc010vjq.1_Nonsense_Mutation_p.S405*|FAM65A_uc002etj.1_Nonsense_Mutation_p.S390*|FAM65A_uc002etk.2_Nonsense_Mutation_p.S390*	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	395						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCACAGCTCTCAGGCACTGCC	0.622		NaN											0	0	0	1	0	44	71									
SLC12A4	6560	broad.mit.edu	37	16	67985897	67985897	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67985897C>T	uc002euz.2	-	8	1102	c.961G>A	c.(961-963)GAC>AAC	p.D321N	SLC12A4_uc010ceu.2_Missense_Mutation_p.D315N|SLC12A4_uc010vkh.1_Missense_Mutation_p.D290N|SLC12A4_uc010vki.1_Missense_Mutation_p.D321N|SLC12A4_uc010vkj.1_Missense_Mutation_p.D323N|SLC12A4_uc002eva.2_Missense_Mutation_p.D321N|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	321					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCACAGATGTCAAACTGGTCC	0.587		NaN											0	0	0	1	0	27	44									
SLC7A6OS	84138	broad.mit.edu	37	16	68344264	68344264	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:68344264C>G	uc002evw.1	-	2	464	c.445G>C	c.(445-447)GAA>CAA	p.E149Q	PRMT7_uc002evx.1_5'Flank|PRMT7_uc002evy.1_5'Flank|PRMT7_uc010vlg.1_5'Flank	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	149					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		GAGGCGGCTTCAGGTTCTCCC	0.612		NaN											0	0	0	1	0	23	19									
PRMT7	54496	broad.mit.edu	37	16	68380131	68380131	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:68380131G>C	uc002evy.1	+	11	1415	c.1139G>C	c.(1138-1140)GGA>GCA	p.G380A	PRMT7_uc002evx.1_Missense_Mutation_p.G380A|PRMT7_uc010vlg.1_Missense_Mutation_p.G330A|PRMT7_uc002evz.1_Missense_Mutation_p.G226A	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	380					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CCTCGGTTTGGAGAGATCAAT	0.562		NaN											0	0	0	1	0	49	63									
CDH3	1001	broad.mit.edu	37	16	68721629	68721629	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:68721629C>T	uc002ewf.2	+	12	2917	c.1785C>T	c.(1783-1785)GTC>GTT	p.V595V	CDH3_uc010vli.1_Silent_p.V540V	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	595	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CGGCAGAGGTCAACGAGGAAG	0.602		NaN											0	0	0	1	0	29	42									
FA2H	79152	broad.mit.edu	37	16	74761154	74761154	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:74761154G>C	uc002fde.1	-	3	562	c.494C>G	c.(493-495)TCT>TGT	p.S165C	FA2H_uc010vmy.1_Intron	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	165					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						GACAGTCTTAGAGAGGCCCTC	0.587		NaN											0	0	0	1	0	25	38									
LDHD	197257	broad.mit.edu	37	16	75150574	75150574	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:75150574C>G	uc002fdm.2	-	1	92	c.45G>C	c.(43-45)TGG>TGC	p.W15C	LDHD_uc002fdn.2_Missense_Mutation_p.W15C	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	15							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						AGTAGCCCCTCCAGGGGAACA	0.627		NaN											0	0	0	1	0	70	112									
TERF2IP	54386	broad.mit.edu	37	16	75690294	75690294	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:75690294C>A	uc002fet.1	+	3	1082	c.985C>A	c.(985-987)CTA>ATA	p.L329I		NM_018975	NP_061848	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting	329					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1						TAACTTGGATCTATCAACAGT	0.388		NaN											1	0	1.4958e-60	1	1.60582e-60	93	168									
CENPN	55839	broad.mit.edu	37	16	81053723	81053723	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:81053723G>C	uc002ffx.2	+	6	1163	c.373G>C	c.(373-375)GAA>CAA	p.E125Q	CENPN_uc002ffw.3_Missense_Mutation_p.E125Q|CENPN_uc010vnl.1_Missense_Mutation_p.E125Q|CENPN_uc010vnm.1_Missense_Mutation_p.E105Q|CENPN_uc002ffy.3_Missense_Mutation_p.E125Q	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	125					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						CAGCTTCAGAGAAACTGAGGA	0.423		NaN											0	0	0	1	0	30	33									
BCMO1	53630	broad.mit.edu	37	16	81303925	81303925	+	Missense_Mutation	SNP	C	C	G	rs141341532	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:81303925C>G	uc002fgn.1	+	7	1223	c.1005C>G	c.(1003-1005)TTC>TTG	p.F335L	BCMO1_uc010vnp.1_Missense_Mutation_p.F266L	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	335					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						ACCAGCTCTTCTACCTGGCCA	0.577		NaN											0	0	0	1	0	46	71									
ZCCHC14	23174	broad.mit.edu	37	16	87448115	87448115	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:87448115G>A	uc002fjz.1	-	10	1124	c.1097C>T	c.(1096-1098)TCG>TTG	p.S366L	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.S142L	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	366					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGGCGGGGCCGAGGGGTTCAG	0.637		NaN											0	0	0	1	0	24	31									
KLHDC4	54758	broad.mit.edu	37	16	87741967	87741967	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:87741967G>A	uc002fki.2	-	11	1599	c.1553C>T	c.(1552-1554)GCG>GTG	p.A518V	LOC100129637_uc002fkg.2_5'Flank|LOC100129637_uc002fke.2_5'Flank|KLHDC4_uc002fkh.1_RNA|KLHDC4_uc010cht.1_Missense_Mutation_p.R203W|KLHDC4_uc002fkj.2_Missense_Mutation_p.A487V|KLHDC4_uc002fkk.2_Missense_Mutation_p.A337V|KLHDC4_uc002fkl.2_Missense_Mutation_p.A461V	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	518										pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		TCAGTCCTCCGCACCGCTCTC	0.622		NaN											0	0	0	1	0	59	90									
ZC3H18	124245	broad.mit.edu	37	16	88677720	88677720	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:88677720C>G	uc002fky.2	+	8	1451	c.1251C>G	c.(1249-1251)CGC>CGG	p.R417R	ZC3H18_uc010voy.1_Silent_p.R300R|ZC3H18_uc010voz.1_Silent_p.R441R|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	417	Potential.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		agcgcgagcgcgagcgggagc	0		NaN											0	0	0	1	0	2	5									
CDT1	81620	broad.mit.edu	37	16	88870299	88870299	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:88870299C>T	uc002flu.2	+	1	114	c.60C>T	c.(58-60)ATC>ATT	p.I20I		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	20	PIP-box K+4 motif.				DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		ccccccgcATCGCGCCGCCCA	0.572		NaN											0	0	0	1	0	13	23									
ANKRD11	29123	broad.mit.edu	37	16	89350394	89350394	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:89350394G>C	uc002fmx.1	-	9	3017	c.2556C>G	c.(2554-2556)TTC>TTG	p.F852L	ANKRD11_uc002fmy.1_Missense_Mutation_p.F852L|ANKRD11_uc002fnc.1_Missense_Mutation_p.F852L|ANKRD11_uc002fnb.1_Missense_Mutation_p.F809L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	852	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTCCCCTTTGAAATCAAAGG	0.488		NaN											0	0	0	1	0	48	59									
MYO1C	4641	broad.mit.edu	37	17	1378124	1378124	+	Silent	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:1378124G>T	uc002fsp.2	-	16	1918	c.1698C>A	c.(1696-1698)CTC>CTA	p.L566L	MYO1C_uc002fsn.2_Silent_p.L547L|MYO1C_uc002fso.2_Silent_p.L531L|MYO1C_uc010vqj.1_Silent_p.L531L|MYO1C_uc010vqk.1_Silent_p.L542L	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	566	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGTTCCGGAAGAGAAGGTCAT	0.637		NaN											1	0	2.17126e-26	1	2.29479e-26	42	7									
TP53	7157	broad.mit.edu	37	17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	18	2									
C17orf59	54785	broad.mit.edu	37	17	8092765	8092765	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:8092765G>C	uc010vut.1	-	1	800	c.694C>G	c.(694-696)CCA>GCA	p.P232A		NM_017622	NP_060092	Q96GS4	CQ059_HUMAN	hypothetical protein LOC54785	232	Pro-rich.										0						GGCGGGGGTGGAGGCGCGCCG	0.682		NaN											0	0	0	1	0	6	2									
RAI1	10743	broad.mit.edu	37	17	17701534	17701534	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:17701534G>A	uc002grm.2	+	3	5741	c.5272G>A	c.(5272-5274)GAC>AAC	p.D1758N	RAI1_uc002grn.1_Missense_Mutation_p.D1758N	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1758						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CCCCAGGCCTGACGGCCCAGC	0.697		NaN											0	0	0	1	0	9	0									
TOP3A	7156	broad.mit.edu	37	17	18188594	18188594	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:18188594G>C	uc002gsx.1	-	15	1968	c.1739C>G	c.(1738-1740)TCT>TGT	p.S580C	TOP3A_uc010cpz.1_Missense_Mutation_p.S32C|TOP3A_uc010vxr.1_Missense_Mutation_p.S110C|TOP3A_uc002gsw.1_Missense_Mutation_p.S32C|TOP3A_uc010vxs.1_Missense_Mutation_p.S478C	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	580					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GTCAGGCTTAGACATTTCATA	0.522		NaN											0	0	0	1	0	42	8									
EFCAB5	374786	broad.mit.edu	37	17	28296332	28296332	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:28296332G>A	uc002het.2	+	4	906	c.714G>A	c.(712-714)ATG>ATA	p.M238I	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Missense_Mutation_p.M182I|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.M117I|EFCAB5_uc010csf.2_Missense_Mutation_p.M117I	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	238							calcium ion binding			ovary(1)|skin(1)	2						AGAGGTTGATGAAAGAAGTCA	0.358		NaN											0	0	0	1	0	44	3									
NF1	4763	broad.mit.edu	37	17	29554250	29554250	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:29554250C>T	uc002hgg.2	+	19	2599	c.2266C>T	c.(2266-2268)CAG>TAG	p.Q756*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q756*|NF1_uc010csn.1_Nonsense_Mutation_p.Q616*|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	756					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.Q756*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGCAGCACTTCAGAAAAGAGT	0.517		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	1	0	172	18									
SUZ12	23512	broad.mit.edu	37	17	30323823	30323823	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:30323823G>C	uc002hgs.2	+	15	2023	c.1801G>C	c.(1801-1803)GAA>CAA	p.E601Q	SUZ12_uc002hgt.2_Missense_Mutation_p.E578Q	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	601	VEFS-box.				negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				CCAGCAAATTGAAGAGTTTTC	0.299		NaN	T	JAZF1	endometrial stromal tumours								0	0	0	1	0	7	62									
GPR179	440435	broad.mit.edu	37	17	36485624	36485624	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36485624C>T	uc002hpz.2	-	11	3849	c.3828G>A	c.(3826-3828)TCG>TCA	p.S1276S		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1276	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTAGTGCCCTCGACTCTGGGG	0.562		NaN											0	0	0	1	0	80	2									
GPR179	440435	broad.mit.edu	37	17	36486316	36486316	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36486316C>T	uc002hpz.2	-	11	3157	c.3136G>A	c.(3136-3138)GAG>AAG	p.E1046K		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1046	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GCGTCCATCTCATTCTCCCCA	0.597		NaN											0	0	0	1	0	87	7									
GPR179	440435	broad.mit.edu	37	17	36486596	36486596	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36486596C>T	uc002hpz.2	-	11	2877	c.2856G>A	c.(2854-2856)AGG>AGA	p.R952R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	952	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GAGATAGCATCCTTGGCTCTC	0.468		NaN											0	0	0	1	0	19	2									
GPR179	440435	broad.mit.edu	37	17	36487082	36487082	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36487082C>T	uc002hpz.2	-	11	2391	c.2370G>A	c.(2368-2370)CTG>CTA	p.L790L		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	790	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GCTTCCTCCTCAGCAGTGAGT	0.657		NaN											0	0	0	1	0	17	2									
KRTAP4-12	83755	broad.mit.edu	37	17	39279805	39279805	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:39279805G>A	uc002hwa.2	-	1	615	c.570C>T	c.(568-570)TGC>TGT	p.C190C		NM_031854	NP_114060	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	190						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGGGGCGGGGGCAGGTGGAGA	0.478		NaN											0	0	0	1	0	3	36									
BRCA1	672	broad.mit.edu	37	17	41245834	41245834	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:41245834C>T	uc002icq.2	-	10	1946	c.1714G>A	c.(1714-1716)GAA>AAA	p.E572K	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.E501K|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.E525K|BRCA1_uc002ict.2_Missense_Mutation_p.E572K|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.E572K|BRCA1_uc002ide.1_Missense_Mutation_p.E403K|BRCA1_uc010cyy.1_Missense_Mutation_p.E572K|BRCA1_uc010whs.1_Missense_Mutation_p.E572K|BRCA1_uc010cyz.2_Missense_Mutation_p.E525K|BRCA1_uc010cza.2_Missense_Mutation_p.E546K|BRCA1_uc010wht.1_Missense_Mutation_p.E276K	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	572					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCGAGTGATTCTATTGGGTTA	0.338		NaN	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	1	0	90	4									
TEX14	56155	broad.mit.edu	37	17	56646611	56646611	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:56646611G>C	uc010dcz.1	-	27	4084	c.3966C>G	c.(3964-3966)TTC>TTG	p.F1322L	TEX14_uc002iwr.1_Missense_Mutation_p.F1316L|TEX14_uc002iws.1_Missense_Mutation_p.F1276L|TEX14_uc010dda.1_Missense_Mutation_p.F1056L	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1322						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATGCTGTGAGAAGGCTTCTA	0.418		NaN											0	0	0	1	0	65	13									
HELZ	9931	broad.mit.edu	37	17	65141996	65141996	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:65141996C>G	uc010wqk.1	-	21	2822	c.2635G>C	c.(2635-2637)GAG>CAG	p.E879Q	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.E878Q	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TAGAAAAGCTCAGAGGTATAA	0.373		NaN											0	0	0	1	0	20	35									
COG1	9382	broad.mit.edu	37	17	71197805	71197805	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:71197805C>G	uc002jjg.2	+	7	1875	c.1839C>G	c.(1837-1839)TTC>TTG	p.F613L	COG1_uc002jjh.2_Missense_Mutation_p.F613L|COG1_uc002jjf.1_Missense_Mutation_p.F613L	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	613					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			CAGTTCTTTTCATGGCCAGAC	0.547		NaN											0	0	0	1	0	57	6									
MIF4GD	57409	broad.mit.edu	37	17	73262901	73262901	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:73262901C>G	uc002jnr.2	-	6	718	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	MIF4GD_uc002jno.2_Missense_Mutation_p.E238Q|MIF4GD_uc002jnp.2_Missense_Mutation_p.E231Q|MIF4GD_uc002jnq.2_Missense_Mutation_p.E238Q			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	197	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TCAATGATCTCCAGCAGCAGC	0.592		NaN											0	0	0	1	0	106	7									
ACOX1	51	broad.mit.edu	37	17	73949633	73949633	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:73949633G>C	uc002jqf.2	-	7	1133	c.843C>G	c.(841-843)GTC>GTG	p.V281V	ACOX1_uc010wsq.1_Silent_p.V243V|ACOX1_uc002jqe.2_Silent_p.V281V|ACOX1_uc010wsr.1_Silent_p.V213V	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	281					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						GGAAGGACCTGACAAACACCA	0.527		NaN											0	0	0	1	0	94	14									
SRP68	6730	broad.mit.edu	37	17	74057619	74057619	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:74057619C>G	uc002jqk.1	-	5	633	c.598G>C	c.(598-600)GAA>CAA	p.E200Q	SRP68_uc010wsu.1_Missense_Mutation_p.E99Q|SRP68_uc002jql.1_Missense_Mutation_p.E162Q	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	200					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TCTTGATGTTCAAAACGTAGC	0.433		NaN											0	0	0	1	0	76	8									
MGAT5B	146664	broad.mit.edu	37	17	74900408	74900408	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:74900408C>T	uc002jti.2	+	5	730	c.627C>T	c.(625-627)CTC>CTT	p.L209L	MGAT5B_uc002jth.2_Silent_p.L198L	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	198	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GCTCCTTCCTCATCTACCTCA	0.667		NaN											0	0	0	1	0	19	1									
SYNGR2	9144	broad.mit.edu	37	17	76167833	76167833	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:76167833C>T	uc002juu.1	+	4	518	c.491C>T	c.(490-492)TCC>TTC	p.S164F	SYNGR2_uc002jut.2_Missense_Mutation_p.P194S|SYNGR2_uc002juv.1_Silent_p.L117L|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	164	MARVEL.|Helical; (Potential).					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			GTGCTGGCCTCCCTGGCCTAC	0.652		NaN											0	0	0	1	0	94	15									
LPIN2	9663	broad.mit.edu	37	18	2937747	2937747	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:2937747C>G	uc002klo.2	-	7	1350	c.1111G>C	c.(1111-1113)GAG>CAG	p.E371Q		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	371					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GAGGGCGCCTCCGCTAAGGCT	0.483		NaN											0	0	0	1	0	45	74									
LAMA1	284217	broad.mit.edu	37	18	6961983	6961983	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:6961983G>C	uc002knm.2	-	52	7507	c.7413C>G	c.(7411-7413)CTC>CTG	p.L2471L	LAMA1_uc002knl.2_5'UTR|LAMA1_uc010wzj.1_Silent_p.L1947L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2471	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAATTTCTGAGTAAGTCAA	0.403		NaN											0	0	0	1	0	83	103									
PTPRM	5797	broad.mit.edu	37	18	8244134	8244134	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:8244134G>C	uc002knn.3	+	15	2882	c.2379G>C	c.(2377-2379)AAG>AAC	p.K793N	PTPRM_uc010dkv.2_Missense_Mutation_p.K793N|PTPRM_uc010wzl.1_Missense_Mutation_p.K580N	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	793	Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CAATGGACAAGAGCTATGCTG	0.463		NaN											0	0	0	1	0	74	90									
NPC1	4864	broad.mit.edu	37	18	21120457	21120457	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:21120457C>G	uc002kum.3	-	17	2833	c.2559G>C	c.(2557-2559)CTG>CTC	p.L853L	NPC1_uc010xaz.1_Silent_p.L586L|NPC1_uc010xba.1_Silent_p.L698L	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	853	Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CTACTTTGTTCAGGACTGCGA	0.358		NaN											0	0	0	1	0	22	51									
OSBPL1A	114876	broad.mit.edu	37	18	21914240	21914240	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:21914240C>T	uc002kve.2	-	6	623	c.449G>A	c.(448-450)AGA>AAA	p.R150K		NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	150					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TTTGCCTTCTCTTGCTGCTGC	0.363		NaN											0	0	0	1	0	30	51									
CHST9	83539	broad.mit.edu	37	18	24496276	24496276	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:24496276C>T	uc002kwd.2	-	5	1477	c.1279G>A	c.(1279-1281)GAC>AAC	p.D427N	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.D342N|CHST9_uc002kwe.2_Missense_Mutation_p.D427N	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	427	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					TAATAAAAGTCATAGATTAAT	0.313		NaN											0	0	0	1	0	30	54									
C18orf34	374864	broad.mit.edu	37	18	30554571	30554571	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:30554571C>T	uc002kxn.2	-	21	2605	c.2463G>A	c.(2461-2463)ATG>ATA	p.M821I	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Missense_Mutation_p.M285I|C18orf34_uc010xbr.1_Missense_Mutation_p.M845I|C18orf34_uc010dmf.1_Missense_Mutation_p.M141I|C18orf34_uc002kxo.2_Missense_Mutation_p.M783I|C18orf34_uc002kxp.2_Missense_Mutation_p.M821I	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	821										ovary(1)	1						TGGCCAGCCTCATCTGGCTGA	0.493		NaN											0	0	0	1	0	51	45									
C18orf34	374864	broad.mit.edu	37	18	30791874	30791874	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:30791874G>C	uc002kxn.2	-	19	2366	c.2224C>G	c.(2224-2226)CTT>GTT	p.L742V	C18orf34_uc010dme.1_Missense_Mutation_p.L256V|C18orf34_uc010xbr.1_Missense_Mutation_p.L742V|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.L704V|C18orf34_uc002kxp.2_Missense_Mutation_p.L742V	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	742										ovary(1)	1						GTATCTTGAAGAGTTTTTTGT	0.328		NaN											0	0	0	1	0	22	29									
PHLPP1	23239	broad.mit.edu	37	18	60645778	60645778	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:60645778G>T	uc002lis.2	+	18	2910	c.2732G>T	c.(2731-2733)AGT>ATT	p.S911I		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1423					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						GTGCAGCTCAGTGTCACTGAG	0.632		NaN											1	0	9.05144e-12	1	9.29403e-12	10	13									
ZNF236	7776	broad.mit.edu	37	18	74583695	74583695	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:74583695G>A	uc002lmi.2	+	5	773	c.575G>A	c.(574-576)AGA>AAA	p.R192K	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.R192K	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	192					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AATATCGACAGAAGTGGATTC	0.418		NaN											0	0	0	1	0	70	86									
ZFR2	23217	broad.mit.edu	37	19	3834946	3834946	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:3834946C>T	uc002lyw.2	-	2	101	c.89G>A	c.(88-90)GGG>GAG	p.G30E	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	30						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		ATAGCTGGCCCCCACAGTGGG	0.637		NaN											0	0	0	1	0	11	5									
TMEM146	257062	broad.mit.edu	37	19	5745940	5745940	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:5745940C>G	uc002mda.2	+	9	735	c.674C>G	c.(673-675)TCA>TGA	p.S225*	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	225	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTCAAGTACTCAGATCACCCC	0.468		NaN											0	0	0	1	0	85	249									
NDUFA7	4701	broad.mit.edu	37	19	8386222	8386222	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:8386222G>A	uc002mjm.1	-	1	59	c.21C>T	c.(19-21)CTC>CTT	p.L7L	RPS28_uc002mjn.2_5'Flank	NM_005001	NP_004992	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	7					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	GCCGCTGGATGAGACGGGTGG	0.716		NaN											0	0	0	1	0	4	4									
MUC16	94025	broad.mit.edu	37	19	9067806	9067806	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:9067806G>C	uc002mkp.2	-	3	19844	c.19640C>G	c.(19639-19641)TCT>TGT	p.S6547C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6549	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACTAGGCCAGAGGTGGGGAG	0.488		NaN											0	0	0	1	0	28	17									
MUC16	94025	broad.mit.edu	37	19	9071775	9071775	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:9071775C>G	uc002mkp.2	-	3	15875	c.15671G>C	c.(15670-15672)AGT>ACT	p.S5224T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5226	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACCCCTGTACTGGAGACCTC	0.507		NaN											0	0	0	1	0	88	53									
YIPF2	78992	broad.mit.edu	37	19	11034009	11034009	+	Silent	SNP	G	G	A	rs151256467	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:11034009G>A	uc002mqb.2	-	9	1033	c.909C>T	c.(907-909)ATC>ATT	p.I303I	YIPF2_uc002mqc.2_Silent_p.I303I	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	303	Lumenal (Potential).					integral to membrane|transport vesicle					0						GGGACAGCGCGATGTTTGAGG	0.627		NaN											0	0	0	1	0	47	140									
ZNF700	90592	broad.mit.edu	37	19	12060829	12060829	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:12060829C>G	uc002msu.2	+	4	2116	c.1990C>G	c.(1990-1992)CAA>GAA	p.Q664E	ZNF700_uc010xme.1_Missense_Mutation_p.Q682E|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	664	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCTTCTTTTCAAATACATGA	0.398		NaN											0	0	0	1	0	26	27									
LPHN1	22859	broad.mit.edu	37	19	14273746	14273746	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:14273746C>G	uc010xnn.1	-	6	1178	c.882G>C	c.(880-882)CAG>CAC	p.Q294H	LPHN1_uc010xno.1_Missense_Mutation_p.Q289H|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	294	Olfactomedin-like.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						AGGGGTTCAGCTGGCTCACCA	0.632		NaN											0	0	0	1	0	11	36									
JAK3	3718	broad.mit.edu	37	19	17953847	17953847	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:17953847C>T	uc002nhn.3	-	5	655	c.555G>A	c.(553-555)CTG>CTA	p.L185L	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Silent_p.L185L|JAK3_uc010xpx.1_Silent_p.L185L|JAK3_uc010xpy.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	185	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGACAGTCTTCAGCAGCTCTC	0.672		2	Mis		acute megakaryocytic leukemia|								0	0	0	1	0	42	28									
UPF1	5976	broad.mit.edu	37	19	18968269	18968269	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:18968269G>C	uc002nkg.2	+	15	2417	c.2142G>C	c.(2140-2142)CGG>CGC	p.R714R	UPF1_uc002nkf.2_Silent_p.R703R|UPF1_uc002nkh.2_5'Flank	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	714				R->A: Impairs ATPase activity and ATP binding.	cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TCCAGTACCGGATGCACCCTG	0.647		NaN											0	0	0	1	0	22	16									
ZNF626	199777	broad.mit.edu	37	19	20807417	20807417	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:20807417C>G	uc002npb.1	-	4	1416	c.1266G>C	c.(1264-1266)GAG>GAC	p.E422D	ZNF626_uc002npc.1_Missense_Mutation_p.E346D	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TGTAGGGTCTCTCTCCAGTAT	0.378		NaN											0	0	0	1	0	46	35									
ZNF91	7644	broad.mit.edu	37	19	23544674	23544674	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:23544674C>G	uc002nre.2	-	4	1220	c.1107G>C	c.(1105-1107)AAG>AAC	p.K369N	ZNF91_uc010xrj.1_Missense_Mutation_p.K337N	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	369	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TATGAGTTATCTTATGATTAG	0.358		NaN											0	0	0	1	0	15	45									
ZNF599	148103	broad.mit.edu	37	19	35251122	35251122	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35251122C>G	uc010edn.1	-	4	972	c.584G>C	c.(583-585)AGG>ACG	p.R195T	ZNF599_uc010edm.1_Missense_Mutation_p.R158T	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			AGGGTTATTCCTTGCATCAGT	0.493		NaN											0	0	0	1	0	37	83									
ZNF599	148103	broad.mit.edu	37	19	35251243	35251243	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35251243C>T	uc010edn.1	-	4	851	c.463G>A	c.(463-465)GAT>AAT	p.D155N	ZNF599_uc010edm.1_Missense_Mutation_p.D118N	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TCCAAATCATCATGTTTATAA	0.438		NaN											0	0	0	1	0	34	127									
ZNF599	148103	broad.mit.edu	37	19	35251274	35251274	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35251274C>G	uc010edn.1	-	4	820	c.432G>C	c.(430-432)GAG>GAC	p.E144D	ZNF599_uc010edm.1_Missense_Mutation_p.E107D	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CAGGGCATATCTCTTTGTGGG	0.448		NaN											0	0	0	1	0	44	161									
GRAMD1A	57655	broad.mit.edu	37	19	35502453	35502453	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35502453G>C	uc010xse.1	+	7	738	c.601G>C	c.(601-603)GAA>CAA	p.E201Q	GRAMD1A_uc002nxi.1_Missense_Mutation_p.E288Q|GRAMD1A_uc002nxk.2_Missense_Mutation_p.E194Q|GRAMD1A_uc002nxl.2_Missense_Mutation_p.L4F|GRAMD1A_uc010xsf.1_Missense_Mutation_p.E206Q|GRAMD1A_uc002nxm.1_5'Flank	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	201						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCACTGCTTGAAAAGGTGGG	0.627		NaN											0	0	0	1	0	30	81									
ZNF781	163115	broad.mit.edu	37	19	38161042	38161042	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:38161042C>G	uc002ogy.2	-	4	750	c.8G>C	c.(7-9)AGA>ACA	p.R3T	ZNF781_uc002ogz.2_5'UTR	NM_152605	NP_689818	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATTGCATTTCTTTGCATTAA	0.343		NaN											0	0	0	1	0	27	81									
SERTAD1	29950	broad.mit.edu	37	19	40929372	40929372	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:40929372G>A	uc002ont.3	-	2	241	c.82C>T	c.(82-84)CCT>TCT	p.P28S		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	28					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTGTGGCCAGGATCTAGCCAC	0.567		NaN											0	0	0	1	0	48	29									
CYP2F1	1572	broad.mit.edu	37	19	41628036	41628036	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:41628036G>C	uc002opu.1	+	6	876	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	CYP2F1_uc010xvw.1_Missense_Mutation_p.E60Q|CYP2F1_uc010xvv.1_Missense_Mutation_p.E274Q|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	274					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CAAGATGGCAGAGGTAATCCC	0.602		NaN											0	0	0	1	0	32	21									
PLAUR	5329	broad.mit.edu	37	19	44156432	44156432	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:44156432G>C	uc002oxf.1	-	6	929	c.699C>G	c.(697-699)TTC>TTG	p.F233L	PLAUR_uc002oxd.1_Missense_Mutation_p.F233L|PLAUR_uc002oxe.1_Missense_Mutation_p.F228L|PLAUR_uc002oxg.1_Missense_Mutation_p.F188L	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	233	UPAR/Ly6 3.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	AGTCAATGAGGAAAGTCTCTT	0.572		NaN									OREG0025532	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	24	62									
PVR	5817	broad.mit.edu	37	19	45164564	45164564	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:45164564G>C	uc002ozm.2	+	7	1455	c.1156G>C	c.(1156-1158)GAG>CAG	p.E386Q	PVR_uc010xxb.1_Missense_Mutation_p.E333Q|PVR_uc010xxc.1_Missense_Mutation_p.E341Q|PVR_uc002ozn.2_Missense_Mutation_p.E331Q	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	386	Cytoplasmic (Potential).				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		CCCAGGTACAGAGCATGCCAG	0.547		NaN											0	0	0	1	0	41	33									
PRKD2	25865	broad.mit.edu	37	19	47181774	47181774	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:47181774C>T	uc002pfh.2	-	17	2559	c.2217G>A	c.(2215-2217)GTG>GTA	p.V739V	PRKD2_uc002pfd.2_Silent_p.V113V|PRKD2_uc010eks.2_Silent_p.V142V|PRKD2_uc010ekt.2_Silent_p.V6V|PRKD2_uc002pfe.2_Silent_p.V259V|PRKD2_uc002pff.2_Silent_p.V259V|PRKD2_uc002pfg.2_Silent_p.V582V|PRKD2_uc002pfi.2_Silent_p.V739V|PRKD2_uc002pfj.2_Silent_p.V739V|PRKD2_uc010xye.1_Silent_p.V739V|PRKD2_uc002pfk.2_Silent_p.V582V	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	739	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CGTACATGATCACGCCCACTG	0.627		NaN											0	0	0	1	0	57	56									
PRKD2	25865	broad.mit.edu	37	19	47204090	47204090	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:47204090C>T	uc002pfh.2	-	8	1429	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K	PRKD2_uc002pfg.2_Missense_Mutation_p.E206K|PRKD2_uc002pfi.2_Missense_Mutation_p.E363K|PRKD2_uc002pfj.2_Missense_Mutation_p.E363K|PRKD2_uc010xye.1_Missense_Mutation_p.E363K|PRKD2_uc002pfk.2_Missense_Mutation_p.E206K	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	363					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity	p.E363E(1)		ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TCCTCCTCCTCACTGGCGTGG	0.587		NaN											0	0	0	1	0	35	34									
CYTH2	9266	broad.mit.edu	37	19	48973714	48973714	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:48973714G>A	uc002pjj.3	+	2	424	c.124G>A	c.(124-126)GAA>AAA	p.E42K	uc002pjg.2_5'Flank|CYTH2_uc010xzr.1_Missense_Mutation_p.E42K|CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	42	Potential.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GGAGCTCAGTGAAGCCATGAG	0.677		NaN											0	0	0	1	0	18	80									
LMTK3	114783	broad.mit.edu	37	19	49000753	49000753	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49000753G>A	uc002pjk.2	-	12	3660	c.3660C>T	c.(3658-3660)CTC>CTT	p.L1220L		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CGTCTCCGCTGAGTGCCGTGT	0.716		NaN											0	0	0	1	0	8	42									
BCAT2	587	broad.mit.edu	37	19	49300454	49300454	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49300454C>G	uc002pkr.2	-	7	869	c.832G>C	c.(832-834)GAT>CAT	p.D278H	BCAT2_uc002pkp.2_Missense_Mutation_p.D238H|BCAT2_uc002pkq.3_Missense_Mutation_p.D238H|BCAT2_uc002pks.2_Missense_Mutation_p.D238H|BCAT2_uc002pkt.2_Missense_Mutation_p.D186H|BCAT2_uc010emh.1_Missense_Mutation_p.D278H|BCAT2_uc010emi.1_Missense_Mutation_p.D186H	NM_001190	NP_001181	O15382	BCAT2_HUMAN	branched chain aminotransferase 2, mitochondrial	278						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			ovary(1)	1		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	TTACCCCCATCTTCGTGGGTC	0.607		NaN											0	0	0	1	0	16	17									
ALDH16A1	126133	broad.mit.edu	37	19	49965030	49965030	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49965030G>A	uc002pnt.2	+	6	848	c.732G>A	c.(730-732)CGG>CGA	p.R244R	ALDH16A1_uc010yar.1_Silent_p.R244R|ALDH16A1_uc010yas.1_Silent_p.R79R|ALDH16A1_uc010yat.1_Silent_p.R81R	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	244							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CTGGAATCCGGAAGGTGGCCT	0.711		NaN											0	0	0	1	0	6	17									
ALDH16A1	126133	broad.mit.edu	37	19	49965915	49965915	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49965915G>A	uc002pnt.2	+	8	1117	c.1001G>A	c.(1000-1002)CGA>CAA	p.R334Q	ALDH16A1_uc010yar.1_Missense_Mutation_p.R283Q|ALDH16A1_uc010yas.1_Missense_Mutation_p.R169Q|ALDH16A1_uc010yat.1_Missense_Mutation_p.R171Q	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	334							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CGGAGTGGCCGAGGGCTGGAT	0.672		NaN											0	0	0	1	0	31	65									
ZNF616	90317	broad.mit.edu	37	19	52618746	52618746	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:52618746G>A	uc002pym.2	-	4	1954	c.1671C>T	c.(1669-1671)GTC>GTT	p.V557V	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	557	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		ATTGACTGAAGACCTTGCCAC	0.438		NaN											0	0	0	1	0	58	34									
ZNF321	399669	broad.mit.edu	37	19	53432634	53432634	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:53432634G>A	uc010eqj.2	-	4	346	c.176C>T	c.(175-177)TCA>TTA	p.S59L	ZNF321_uc002qaj.1_Missense_Mutation_p.S6L|ZNF321_uc002qak.1_Missense_Mutation_p.S59L	NM_203307	NP_976052			zinc finger protein 321												0				GBM - Glioblastoma multiforme(134;0.0305)		CGCTGTGGATGAGAACTCCTT	0.353		NaN											0	0	0	1	0	104	88									
TNNT1	7138	broad.mit.edu	37	19	55645272	55645272	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:55645272G>A	uc002qjb.3	-	13	863	c.774C>T	c.(772-774)ATC>ATT	p.I258I	TNNT1_uc002qiz.3_Silent_p.I172I|TNNT1_uc002qja.3_Silent_p.I172I|TNNT1_uc002qjc.3_Silent_p.I242I|TNNT1_uc002qje.3_Silent_p.I231I|TNNT1_uc002qjd.3_Silent_p.I231I	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	258					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GGGCGTGGCTGATGCGGTTGT	0.627		NaN											0	0	0	1	0	50	30									
C19orf51	352909	broad.mit.edu	37	19	55672758	55672758	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:55672758C>A	uc002qji.1	-	7	726	c.692G>T	c.(691-693)CGA>CTA	p.R231L	C19orf51_uc002qjh.1_Missense_Mutation_p.R46L|C19orf51_uc002qjj.1_Missense_Mutation_p.R278L|C19orf51_uc002qjk.1_Missense_Mutation_p.R177L|C19orf51_uc002qjl.1_Missense_Mutation_p.R299L			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	231											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CCGCCAGCGTCGGAACTCCTG	0.587		NaN											1	0	0.00307968	1	0.00309483	6	16									
NLRP8	126205	broad.mit.edu	37	19	56466732	56466732	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:56466732C>T	uc002qmh.2	+	3	1379	c.1308C>T	c.(1306-1308)CCC>CCT	p.P436P	NLRP8_uc010etg.2_Silent_p.P436P	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	436	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCTTGTTTCCCACCAGAGCTG	0.488		NaN											0	0	0	1	0	65	42									
ZNF582	147948	broad.mit.edu	37	19	56895395	56895395	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:56895395G>C	uc002qmz.1	-	5	1550	c.1391C>G	c.(1390-1392)TCA>TGA	p.S464*	ZNF582_uc002qmy.2_Nonsense_Mutation_p.S495*	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		AACGGTAGTTGAATCATGACT	0.363		NaN											0	0	0	1	0	23	108									
ZNF470	388566	broad.mit.edu	37	19	57088680	57088680	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:57088680C>G	uc002qnl.3	+	6	1559	c.883C>G	c.(883-885)CAG>GAG	p.Q295E	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	295	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGCCTTCAGCCAGAATGCTCA	0.448		NaN											0	0	0	1	0	58	50									
MZF1	7593	broad.mit.edu	37	19	59073565	59073565	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:59073565C>T	uc002qto.2	-	6	2640	c.2079G>A	c.(2077-2079)CGG>CGA	p.R693R	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Silent_p.R693R	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	693	C2H2-type 12.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TGAGCGTGGGCCGCTGGCGGA	0.667		NaN											0	0	0	1	0	7	26									
CPSF3	51692	broad.mit.edu	37	2	9583767	9583767	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:9583767C>T	uc002qzo.1	+	10	1254	c.1219C>T	c.(1219-1221)CGT>TGT	p.R407C	CPSF3_uc010ewx.1_Intron|CPSF3_uc002qzp.1_Missense_Mutation_p.R370C	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	407					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TGAATTTATTCGTGCTTTGAA	0.388		NaN											0	0	0	1	0	59	113									
NTSR2	23620	broad.mit.edu	37	2	11802148	11802148	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:11802148C>T	uc002rbq.3	-	2	917	c.843G>A	c.(841-843)GTG>GTA	p.V281V		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	281	Cytoplasmic (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	CTTTATGTCTCACCAGGCTGA	0.557		NaN											0	0	0	1	0	68	81									
C2orf39	92749	broad.mit.edu	37	2	26624903	26624903	+	Nonsense_Mutation	SNP	G	G	T	rs149082901		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:26624903G>T	uc002rhg.2	+	1	120	c.46G>T	c.(46-48)GAG>TAG	p.E16*	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	16											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAACGTGGACGAGCACTTGTC	0.677		NaN											1	0	2.89027e-11	1	2.94798e-11	20	28									
EMILIN1	11117	broad.mit.edu	37	2	27302012	27302012	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:27302012C>G	uc002rii.3	+	1	507	c.79C>G	c.(79-81)CGA>GGA	p.R27G	EMILIN1_uc010eyq.1_Missense_Mutation_p.R27G	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	27					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTACCCTCCTCGAGGTTTCAG	0.716		NaN											0	0	0	1	0	12	18									
C2orf53	339779	broad.mit.edu	37	2	27360541	27360541	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:27360541C>T	uc002rjb.2	-	3	1237	c.657G>A	c.(655-657)CTG>CTA	p.L219L	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	219											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCGGTGCCCCAGCTGGACCA	0.662		NaN											0	0	0	1	0	36	33									
ZNF513	130557	broad.mit.edu	37	2	27600419	27600419	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:27600419G>T	uc002rkk.2	-	4	1819	c.1619C>A	c.(1618-1620)TCA>TAA	p.S540*	ZNF513_uc002rkj.2_Nonsense_Mutation_p.S478*	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	540					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTTCAGGATGAGTCTGTGTG	0.607		NaN											1	0	8.16277e-20	1	8.48098e-20	32	56									
BIRC6	57448	broad.mit.edu	37	2	32716581	32716581	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:32716581C>G	uc010ezu.2	+	44	8430	c.8296C>G	c.(8296-8298)CTT>GTT	p.L2766V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2766					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGTGAAATTTCTTTCTGGCAC	0.398		NaN											0	0	0	1	0	72	101									
BIRC6	57448	broad.mit.edu	37	2	32740370	32740370	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:32740370G>C	uc010ezu.2	+	55	11016	c.10882G>C	c.(10882-10884)GAC>CAC	p.D3628H		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3628					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ACAATTACTAGACTCAGGTTT	0.418		NaN											0	0	0	1	0	38	47									
SLC8A1	6546	broad.mit.edu	37	2	40656481	40656481	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:40656481C>A	uc002rrx.2	-	1	964	c.940G>T	c.(940-942)GAG>TAG	p.E314*	SLC8A1_uc002rry.2_Nonsense_Mutation_p.E314*|SLC8A1_uc002rrz.2_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsa.2_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsd.3_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsb.1_Nonsense_Mutation_p.E314*|SLC8A1_uc010fan.1_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsc.1_Nonsense_Mutation_p.E314*	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	314	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGGTCCCTCTCATCCACCTCC	0.413		NaN											1	0	1.46924e-35	1	1.56091e-35	83	129									
SPTBN1	6711	broad.mit.edu	37	2	54859746	54859746	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:54859746G>C	uc002rxu.2	+	17	3857	c.3608G>C	c.(3607-3609)GGA>GCA	p.G1203A	SPTBN1_uc002rxx.2_Missense_Mutation_p.G1190A	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1203	Spectrin 9.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACCTTGGAAGGAGCTGAAGCA	0.458		NaN											0	0	0	1	0	38	47									
PUS10	150962	broad.mit.edu	37	2	61175207	61175207	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:61175207G>A	uc010fci.2	-	16	1482	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	PUS10_uc002sao.2_Silent_p.F474F|PUS10_uc010ypk.1_Silent_p.F251F	NM_144709	NP_653310	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	474					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			AGTGGAGGCGGAAGTGGTGCT	0.547		NaN											0	0	0	1	0	116	130									
MPHOSPH10	10199	broad.mit.edu	37	2	71360405	71360405	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:71360405G>A	uc002sht.1	+	2	819	c.467G>A	c.(466-468)AGC>AAC	p.S156N	MPHOSPH10_uc010feb.1_Missense_Mutation_p.S156N	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	156					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GAAAACTCAAGCAAATCTGAT	0.448		NaN											0	0	0	1	0	59	76									
MPHOSPH10	10199	broad.mit.edu	37	2	71360599	71360599	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:71360599G>C	uc002sht.1	+	2	1013	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	MPHOSPH10_uc010feb.1_Missense_Mutation_p.E221Q	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	221	Potential.				RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						AGAAAAAGAAGAGGAACGAAA	0.338		NaN											0	0	0	1	0	40	33									
MPHOSPH10	10199	broad.mit.edu	37	2	71360641	71360641	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:71360641G>C	uc002sht.1	+	2	1055	c.703G>C	c.(703-705)GAT>CAT	p.D235H	MPHOSPH10_uc010feb.1_Missense_Mutation_p.D235H	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	235	Potential.				RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GGAAGATATTGATTTTTTTGA	0.343		NaN											0	0	0	1	0	49	52									
MOGS	7841	broad.mit.edu	37	2	74689845	74689845	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:74689845C>T	uc010ffj.2	-	4	1234	c.1071G>A	c.(1069-1071)CTG>CTA	p.L357L	MOGS_uc010ffh.2_Silent_p.L82L|MOGS_uc010yrt.1_Silent_p.L238L|MOGS_uc010ffi.2_Silent_p.L251L	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	357	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GGGCCTGGGTCAGTAGACTGC	0.542		NaN											0	0	0	1	0	55	62									
HTRA2	27429	broad.mit.edu	37	2	74757145	74757145	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:74757145G>A	uc002smi.1	+	1	614	c.12G>A	c.(10-12)CCG>CCA	p.P4P	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.P4P|HTRA2_uc002smk.1_Silent_p.P4P|HTRA2_uc002sml.1_Silent_p.P4P|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	4					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGGCTGCGCCGAGGGCGGGGC	0.741		NaN											0	0	0	1	0	57	67									
SEMA4F	10505	broad.mit.edu	37	2	74907021	74907021	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:74907021C>T	uc002sna.1	+	14	2109	c.1998C>T	c.(1996-1998)TTC>TTT	p.F666F	SEMA4F_uc010ffr.1_Silent_p.F278F|SEMA4F_uc002snb.1_Silent_p.F278F|SEMA4F_uc002snc.1_Silent_p.F511F	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	666	Helical; (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGGCTGGCTTCTTCTTGGGGA	0.627		NaN											0	0	0	1	0	33	45									
KDM3A	55818	broad.mit.edu	37	2	86707394	86707394	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:86707394C>T	uc002sri.3	+	16	2748	c.2421C>T	c.(2419-2421)GCC>GCT	p.A807A	KDM3A_uc010ytj.1_Silent_p.A807A|KDM3A_uc010ytk.1_Silent_p.A755A	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	807					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						CCAAGCCAGCCGGCAGCATGA	0.567		NaN											0	0	0	1	0	25	22									
ANKRD36B	57730	broad.mit.edu	37	2	98206122	98206122	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:98206122G>A	uc010yvc.1	-	1	307	c.27C>T	c.(25-27)TTC>TTT	p.F9F	ANKRD36B_uc010yve.1_RNA|ANKRD36B_uc010fif.2_RNA	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B	9											0						GGGGAAATGCGAAGCCATCCG	0.512		NaN											0	0	0	1	0	30	47									
POU3F3	5455	broad.mit.edu	37	2	105472929	105472929	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:105472929G>A	uc010ywg.1	+	1	961	c.961G>A	c.(961-963)GAC>AAC	p.D321N		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	321	POU-specific.				metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						GACGTCGGACGACCTGGAGCA	0.617		NaN											0	0	0	1	0	34	34									
DPP10	57628	broad.mit.edu	37	2	116485505	116485505	+	Silent	SNP	A	A	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:116485505A>G	uc002tla.1	+	8	1147	c.690A>G	c.(688-690)TTA>TTG	p.L230L	DPP10_uc002tlb.1_Silent_p.L180L|DPP10_uc002tlc.1_Silent_p.L226L|DPP10_uc002tle.2_Silent_p.L234L|DPP10_uc002tlf.1_Silent_p.L223L	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	230	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CTGACTGGTTATATGAAGGTG	0.299		NaN											0	0	0	1	0	19	19									
DDX18	8886	broad.mit.edu	37	2	118577326	118577326	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:118577326G>A	uc002tlh.1	+	3	571	c.472G>A	c.(472-474)GAA>AAA	p.E158K		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	158							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						AGATAATGATGAAGATGAGAG	0.413		NaN									OREG0003814	type=REGULATORY REGION|Gene=DDX18|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	1	0	17	45									
CNTNAP5	129684	broad.mit.edu	37	2	125555701	125555701	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:125555701G>A	uc002tno.2	+	19	3382	c.3018G>A	c.(3016-3018)ACG>ACA	p.T1006T	CNTNAP5_uc010flu.2_Silent_p.T1007T	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1006	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGGCTGGCACGTCGGTTACTT	0.423		NaN											0	0	0	1	0	8	6									
UGGT1	56886	broad.mit.edu	37	2	128935411	128935411	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:128935411G>C	uc002tps.2	+	33	3808	c.3630G>C	c.(3628-3630)CAG>CAC	p.Q1210H	UGGT1_uc002tpr.2_Missense_Mutation_p.Q1186H	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1210					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TGCAGGTTCAGAAGAAGGCAG	0.418		NaN											0	0	0	1	0	96	288									
SMPD4	55627	broad.mit.edu	37	2	130911411	130911411	+	Nonsense_Mutation	SNP	G	G	C	rs142449057		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:130911411G>C	uc002tqq.1	-	17	2394	c.1874C>G	c.(1873-1875)TCA>TGA	p.S625*	SMPD4_uc002tqo.1_Nonsense_Mutation_p.S157*|SMPD4_uc002tqp.1_Nonsense_Mutation_p.S364*|SMPD4_uc010yzy.1_Nonsense_Mutation_p.S374*|SMPD4_uc010yzz.1_Nonsense_Mutation_p.S289*|SMPD4_uc002tqr.1_Nonsense_Mutation_p.S596*|SMPD4_uc002tqs.1_Nonsense_Mutation_p.S493*|SMPD4_uc002tqt.1_Nonsense_Mutation_p.S474*|SMPD4_uc010zaa.1_Nonsense_Mutation_p.S483*|SMPD4_uc010zab.1_Nonsense_Mutation_p.S523*|SMPD4_uc010zac.1_Nonsense_Mutation_p.S366*|SMPD4_uc010zad.1_Nonsense_Mutation_p.S261*	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	586					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GCCCAGCCATGAGAGGAAGGA	0.592		NaN											0	0	0	1	0	138	76									
ACMSD	130013	broad.mit.edu	37	2	135655919	135655919	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:135655919C>T	uc002ttz.2	+	9	925	c.858C>T	c.(856-858)GTC>GTT	p.V286V	ACMSD_uc002tua.2_Silent_p.V228V|uc010zbe.1_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	286					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		AGGATAAAGTCATTTTGGGAA	0.343		NaN											0	0	0	1	0	277	37									
XIRP2	129446	broad.mit.edu	37	2	168104227	168104227	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:168104227G>A	uc002udx.2	+	8	6343	c.6325G>A	c.(6325-6327)GAT>AAT	p.D2109N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D1934N|XIRP2_uc010fpq.2_Missense_Mutation_p.D1887N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1934					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAAGAAGGATGATGTCTTTAA	0.368		NaN											0	0	0	1	0	39	10									
TTN	7273	broad.mit.edu	37	2	179406276	179406276	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:179406276C>G	uc010zfg.1	-	299	90048	c.89824G>C	c.(89824-89826)GAT>CAT	p.D29942H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D23637H|TTN_uc010zfi.1_Missense_Mutation_p.D23570H|TTN_uc010zfj.1_Missense_Mutation_p.D23445H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30869							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGGAAACATCAAATATCTGT	0.443		NaN											0	0	0	1	0	11	3									
TTN	7273	broad.mit.edu	37	2	179435914	179435914	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:179435914C>G	uc010zfg.1	-	275	67465	c.67241G>C	c.(67240-67242)AGA>ACA	p.R22414T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16109T|TTN_uc010zfi.1_Missense_Mutation_p.R16042T|TTN_uc010zfj.1_Missense_Mutation_p.R15917T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23341							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAGAGACTCTAAATTCATA	0.443		NaN											0	0	0	1	0	61	18									
CCDC141	285025	broad.mit.edu	37	2	179701672	179701673	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:179701672_179701673GG>AA	uc002unf.1	-	13	2605_2606	c.2548_2549CC>TT	c.(2548-2550)CCA>TTA	p.P850L	CCDC141_uc002une.1_Missense_Mutation_p.P300L	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	850	Ig-like.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CAAAGTCACTGGAGAACCTTCC	0.446		NaN											0	0	0	1	0	28	8									
CERKL	375298	broad.mit.edu	37	2	182430845	182430845	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:182430845A>G	uc002unx.2	-	4	718	c.617T>C	c.(616-618)ATG>ACG	p.M206T	CERKL_uc002uny.2_Missense_Mutation_p.M206T|CERKL_uc010zfm.1_Missense_Mutation_p.M162T|CERKL_uc002unz.2_Intron|CERKL_uc002uoa.2_Intron|CERKL_uc002uob.2_Intron|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_Intron|CERKL_uc002uod.1_Missense_Mutation_p.M1T|CERKL_uc002uoe.2_Missense_Mutation_p.M206T	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	206	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTCATATTCCATTACTATTAA	0.308		NaN											0	0	0	1	0	46	9									
ASNSD1	54529	broad.mit.edu	37	2	190532598	190532598	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:190532598G>C	uc002uqt.2	+	5	2007	c.1573G>C	c.(1573-1575)GAA>CAA	p.E525Q		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	525	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			AATAATGATGGAACTGGGTCG	0.413		NaN											0	0	0	1	0	65	12									
CLK1	1195	broad.mit.edu	37	2	201718103	201718103	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:201718103C>T	uc002uwe.2	-	13	1562	c.1381G>A	c.(1381-1383)GAT>AAT	p.D461N	CLK1_uc002uwd.2_Missense_Mutation_p.D284N|CLK1_uc010zhi.1_Missense_Mutation_p.D503N|CLK1_uc002uwf.2_Missense_Mutation_p.D235N|CLK1_uc002uwg.2_Missense_Mutation_p.D310N|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	461	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TTGGCTGGATCATACTCCAAC	0.368		NaN											0	0	0	1	0	35	11									
CCDC108	255101	broad.mit.edu	37	2	219900268	219900268	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:219900268C>G	uc002vjl.1	-	5	560	c.476G>C	c.(475-477)GGA>GCA	p.G159A	CCDC108_uc010zkp.1_Missense_Mutation_p.G148A|CCDC108_uc010zkq.1_Missense_Mutation_p.G94A|CCDC108_uc002vjn.2_Missense_Mutation_p.G94A	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	159						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTCTCCTTTCCTAGCTCCCA	0.502		NaN											0	0	0	1	0	77	26									
ALPI	248	broad.mit.edu	37	2	233321358	233321358	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:233321358G>C	uc002vst.3	+	3	330	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	ALPI_uc002vsu.3_5'UTR	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	85					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ACTGGGGCCTGAGACGCCCCT	0.607		NaN											0	0	0	1	0	13	1									
AGAP1	116987	broad.mit.edu	37	2	236957880	236957880	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:236957880A>G	uc002vvs.2	+	16	2664	c.2069A>G	c.(2068-2070)GAA>GGA	p.E690G	AGAP1_uc002vvt.2_Missense_Mutation_p.E637G	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	690	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						AGCGTCTGGGAAGAGAGCAGC	0.567		NaN											0	0	0	1	0	45	11									
CSRP2BP	57325	broad.mit.edu	37	20	18123337	18123337	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:18123337C>G	uc002wqj.2	+	2	655	c.33C>G	c.(31-33)ATC>ATG	p.I11M	CSRP2BP_uc002wqk.2_5'Flank	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	11					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						GTAGTCTGATCAGTCGGCATG	0.527		NaN											0	0	0	1	0	22	25									
ASXL1	171023	broad.mit.edu	37	20	30956842	30956842	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:30956842C>G	uc002wxs.2	+	3	594	c.168C>G	c.(166-168)CTC>CTG	p.L56L	ASXL1_uc002wxr.1_RNA|ASXL1_uc002wxt.2_RNA|ASXL1_uc010geb.2_5'UTR	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	56					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TCGCATGCCTCAATGCTATGC	0.443		NaN	F|N|Mis		MDS|CMML								0	0	0	1	0	59	73									
EDEM2	55741	broad.mit.edu	37	20	33703305	33703305	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:33703305G>A	uc002xbo.2	-	11	1768	c.1668C>T	c.(1666-1668)CTC>CTT	p.L556L	EDEM2_uc010zus.1_Silent_p.L335L|EDEM2_uc002xbq.2_Silent_p.L519L|EDEM2_uc010zut.1_Silent_p.L515L|EDEM2_uc002xbp.2_Silent_p.L404L|EDEM2_uc002xbn.2_Silent_p.L404L|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Silent_p.L280L	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	556					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TGGGGCAGCTGAGAAGTGGGA	0.488		NaN											0	0	0	1	0	131	193									
CEP250	11190	broad.mit.edu	37	20	34091303	34091303	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:34091303G>C	uc002xcm.2	+	31	5777	c.5106G>C	c.(5104-5106)CAG>CAC	p.Q1702H	CEP250_uc010zve.1_Missense_Mutation_p.Q1070H	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1702	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TGACCACTCAGAGGCAGCTGA	0.587		NaN											0	0	0	1	0	66	93									
SLA2	84174	broad.mit.edu	37	20	35243657	35243657	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:35243657G>C	uc002xfv.2	-	6	865	c.503C>G	c.(502-504)TCA>TGA	p.S168*	SLA2_uc002xfu.2_Nonsense_Mutation_p.S168*	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2 isoform a	168	SH2.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GGCCTGGAGTGAGGGGAAGGT	0.617		NaN											0	0	0	1	0	32	71									
BPI	671	broad.mit.edu	37	20	36948673	36948673	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:36948673G>T	uc002xib.2	+	7	827	c.765G>T	c.(763-765)ATG>ATT	p.M255I		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	255					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				ATGTACAGATGAAGGTGAGGC	0.468		NaN											1	0	3.86903e-22	1	4.05421e-22	30	37									
SLC32A1	140679	broad.mit.edu	37	20	37356882	37356882	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:37356882C>A	uc002xjc.2	+	2	1441	c.1178C>A	c.(1177-1179)TCC>TAC	p.S393Y		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	393	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCGCTGTTGTCCTATCCTCTG	0.627		NaN											1	0	2.44723e-14	1	2.52127e-14	21	49									
SERINC3	10955	broad.mit.edu	37	20	43129838	43129838	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:43129838C>G	uc002xme.2	-	9	1293	c.1159G>C	c.(1159-1161)GAT>CAT	p.D387H	SERINC3_uc002xmf.1_Missense_Mutation_p.D387H|SERINC3_uc010ggs.1_Missense_Mutation_p.D380H|SERINC3_uc010zwp.1_Missense_Mutation_p.D332H	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	387	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GGCTGTCCATCTTCTTCATCA	0.517		NaN											0	0	0	1	0	70	101									
PCIF1	63935	broad.mit.edu	37	20	44571881	44571881	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:44571881C>T	uc002xqs.2	+	8	1133	c.819C>T	c.(817-819)ATC>ATT	p.I273I	PCIF1_uc002xqt.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	273						nucleus				skin(1)	1						ACATTCCTATCAGGTACAGCT	0.517		NaN											0	0	0	1	0	57	85									
PRPF6	24148	broad.mit.edu	37	20	62659061	62659061	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:62659061C>T	uc002yho.2	+	17	2479	c.2311C>T	c.(2311-2313)CTG>TTG	p.L771L	PRPF6_uc002yhp.2_Silent_p.L731L	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	771					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					AAAGTCTCGTCTGAAGAACCC	0.612		NaN											0	0	0	1	0	96	88									
PRDM15	63977	broad.mit.edu	37	21	43222884	43222884	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr21:43222884C>G	uc002yzq.1	-	30	4140	c.4029G>C	c.(4027-4029)CAG>CAC	p.Q1343H	PRDM15_uc002yzo.2_Missense_Mutation_p.Q1014H|PRDM15_uc002yzp.2_Missense_Mutation_p.Q1034H|PRDM15_uc002yzr.1_Missense_Mutation_p.Q1034H	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCTGAATGCTCTGTACTGCGG	0.527		NaN											0	0	0	1	0	116	145									
KRTAP10-10	353333	broad.mit.edu	37	21	46057969	46057969	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr21:46057969C>T	uc002zfq.2	+	1	697	c.635C>T	c.(634-636)TCT>TTT	p.S212F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	212	15 X 5 AA repeats of C-C-X(3).					keratin filament					0						TGCGGTGCCTCTGCCTCCTCC	0.697		NaN											0	0	0	1	0	78	85									
UFD1L	7353	broad.mit.edu	37	22	19459219	19459219	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:19459219G>C	uc002zpm.2	-	4	412	c.282C>G	c.(280-282)CTC>CTG	p.L94L	UFD1L_uc002zpo.2_Silent_p.L94L|UFD1L_uc011agy.1_Silent_p.L94L|UFD1L_uc002zpp.2_Silent_p.L47L|UFD1L_uc010grq.2_Silent_p.L47L	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	94					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					CCCAGTGTGGGAGGTAGCAGA	0.572		NaN											0	0	0	1	0	26	46									
DERL3	91319	broad.mit.edu	37	22	24179997	24179997	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:24179997G>A	uc002zyh.2	-	5	397	c.372C>T	c.(370-372)CTC>CTT	p.L124L	DERL3_uc002zyk.3_Silent_p.L124L|DERL3_uc002zyi.2_Silent_p.L124L|DERL3_uc002zyj.2_Intron	NM_001002862	NP_001002862	Q96Q80	DERL3_HUMAN	derlin 3 isoform 2	124	Lumenal (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	integral to endoplasmic reticulum membrane	protein binding			ovary(1)	1						GCATGGCCATGAGGGCCTGGC	0.677		NaN											0	0	0	1	0	33	51									
CYTSA	23384	broad.mit.edu	37	22	24717865	24717865	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:24717865G>C	uc002zzw.2	+	5	1224	c.917G>C	c.(916-918)GGA>GCA	p.G306A	CYTSA_uc002zzv.3_Missense_Mutation_p.G306A|CYTSA_uc011ajq.1_Missense_Mutation_p.G306A	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	306					cell cycle|cell division						0						CAGAGCGATGGAGGAGGAACT	0.493		NaN											0	0	0	1	0	65	123									
RNF215	200312	broad.mit.edu	37	22	30780387	30780387	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:30780387C>G	uc003ahp.2	-	5	685	c.685G>C	c.(685-687)GAT>CAT	p.D229H	RNF215_uc011akw.1_Missense_Mutation_p.D134H	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	229	Extracellular (Potential).					integral to membrane	zinc ion binding			central_nervous_system(1)	1						CCATAGCCATCCTTGGAGAGG	0.602		NaN											0	0	0	1	0	52	79									
SEC14L2	23541	broad.mit.edu	37	22	30803141	30803141	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:30803141G>C	uc003ahr.2	+	4	405	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	SEC14L2_uc003ahq.2_Missense_Mutation_p.E78Q|SEC14L2_uc011akx.1_Missense_Mutation_p.E24Q|SEC14L2_uc003ahs.2_Intron|SEC14L2_uc011aky.1_Intron|SEC14L2_uc003aht.2_5'Flank|SEC14L2_uc003ahu.3_5'Flank|SEC14L2_uc010gvv.2_5'Flank|SEC14L2_uc010gvw.1_5'Flank|MTP18_uc010gvx.1_5'Flank|MTP18_uc003ahv.1_5'Flank|MTP18_uc010gvy.1_5'Flank	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	78	CRAL-TRIO.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	GCAGCCTCCAGAGGTGAGCAC	0.473		NaN											0	0	0	1	0	30	29									
DEPDC5	9681	broad.mit.edu	37	22	32269279	32269279	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:32269279C>G	uc003als.2	+	34	3573	c.3431C>G	c.(3430-3432)TCT>TGT	p.S1144C	DEPDC5_uc011als.1_Missense_Mutation_p.S1075C|DEPDC5_uc011alu.1_Missense_Mutation_p.S1175C|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.S1166C|DEPDC5_uc003alu.2_Missense_Mutation_p.S593C|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_3'UTR|DEPDC5_uc003alw.2_Missense_Mutation_p.S442C|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_Missense_Mutation_p.S170C|DEPDC5_uc011aly.1_5'UTR	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1144					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ACCTCATCCTCTACCCTGACA	0.547		NaN											0	0	0	1	0	67	117									
EP300	2033	broad.mit.edu	37	22	41489048	41489048	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:41489048A>C	uc003azl.3	+	1	435	c.40A>C	c.(40-42)AAG>CAG	p.K14Q		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	14	Interaction with ALX1.|Nuclear localization signal (Potential).				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GCCTTCAGCCAAGCGGCCTAA	0.547		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	1	0	128	151									
TCF20	6942	broad.mit.edu	37	22	42609617	42609617	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:42609617C>T	uc003bcj.1	-	1	1829	c.1695G>A	c.(1693-1695)CAG>CAA	p.Q565Q	TCF20_uc003bck.1_Silent_p.Q565Q|TCF20_uc003bnt.2_Silent_p.Q565Q	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GGGGTTCATTCTGAGCACCTT	0.582		NaN											0	0	0	1	0	41	54									
TUBGCP6	85378	broad.mit.edu	37	22	50682166	50682166	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:50682166G>C	uc003bkb.1	-	1	1235	c.723C>G	c.(721-723)CTC>CTG	p.L241L	TUBGCP6_uc010har.1_Silent_p.L241L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Silent_p.L241L	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	241					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCAGCCCAGAGAGGTCCGCAT	0.522		NaN											0	0	0	1	0	36	47									
TUBGCP6	85378	broad.mit.edu	37	22	50682726	50682726	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:50682726G>A	uc003bkb.1	-	1	675	c.163C>T	c.(163-165)CAA>TAA	p.Q55*	TUBGCP6_uc010har.1_Nonsense_Mutation_p.Q55*|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Nonsense_Mutation_p.Q55*	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	55					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCAGCTGTTGAGTCTCATCT	0.532		NaN											0	0	0	1	0	61	97									
SH3BP5	9467	broad.mit.edu	37	3	15300495	15300495	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:15300495C>G	uc003bzp.1	-	7	921	c.732G>C	c.(730-732)AAG>AAC	p.K244N	SH3BP5_uc010hem.1_Intron|SH3BP5_uc003bzq.1_Missense_Mutation_p.K87N|SH3BP5_uc003bzr.1_Missense_Mutation_p.K87N|uc003bzo.1_RNA	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	244					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						TCAGGGCCATCTTGTACTCGC	0.557		NaN											0	0	0	1	0	46	62									
EOMES	8320	broad.mit.edu	37	3	27761760	27761760	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:27761760T>C	uc003cdx.2	-	2	938	c.938A>G	c.(937-939)TAC>TGC	p.Y313C	EOMES_uc003cdy.3_Missense_Mutation_p.Y313C|EOMES_uc010hfn.2_Missense_Mutation_p.Y313C|EOMES_uc011axc.1_Missense_Mutation_p.Y18C	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	313	T-box.				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						GAACACATTGTAGTGGGCAGT	0.502		NaN											0	0	0	1	0	194	234									
GOLGA4	2803	broad.mit.edu	37	3	37388779	37388779	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:37388779G>C	uc003cgv.2	+	21	6872	c.6568G>C	c.(6568-6570)GAG>CAG	p.E2190Q	GOLGA4_uc003cgw.2_Missense_Mutation_p.E2205Q|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.E2071Q	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2190	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GATGGGTCGTGAGACTAAGGT	0.373		NaN											0	0	0	1	0	70	91									
XIRP1	165904	broad.mit.edu	37	3	39226133	39226133	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:39226133C>G	uc003cjk.1	-	2	5025	c.4804G>C	c.(4804-4806)GAG>CAG	p.E1602Q	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.E285Q	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1602							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCTCCGACCTCCTGGCCTGAG	0.562		NaN											0	0	0	1	0	190	177									
CELSR3	1951	broad.mit.edu	37	3	48664109	48664109	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:48664109C>T	uc003cuf.1	-	54	12241	c.12241G>A	c.(12241-12243)GAC>AAC	p.D4081N	SLC26A6_uc003cug.2_Missense_Mutation_p.D674N|SLC26A6_uc003cuh.2_Missense_Mutation_p.D695N|SLC26A6_uc010hke.2_Missense_Mutation_p.D527N|SLC26A6_uc003cuk.2_Missense_Mutation_p.D587N|SLC26A6_uc003cui.2_Missense_Mutation_p.D694N|SLC26A6_uc003cuj.2_Missense_Mutation_p.D676N|SLC26A6_uc011bbp.1_Missense_Mutation_p.D659N	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCCCGGAAGTCATGGAAAATC	0.602		NaN											0	0	0	1	0	166	307									
USP4	7375	broad.mit.edu	37	3	49339954	49339954	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:49339954G>A	uc003cwq.2	-	10	1229	c.1150C>T	c.(1150-1152)CCT>TCT	p.P384S	USP4_uc003cwo.2_Missense_Mutation_p.P114S|USP4_uc003cwp.2_Missense_Mutation_p.P114S|USP4_uc003cwr.2_Missense_Mutation_p.P337S	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	384					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GAAAATTGAGGAGCAAAACGT	0.388		NaN											0	0	0	1	0	49	34									
MST1	4485	broad.mit.edu	37	3	49724610	49724610	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:49724610C>G	uc003cxg.2	-	5	651	c.579G>C	c.(577-579)CAG>CAC	p.Q193H	MST1_uc011bcs.1_Missense_Mutation_p.Q193H|MST1_uc010hkx.2_Missense_Mutation_p.Q114H|MST1_uc011bct.1_Missense_Mutation_p.Q193H|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	179	Kringle 1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGCCGCAGCTCTGGAAGCGCA	0.622		NaN											0	0	0	1	0	36	67									
DNAH1	25981	broad.mit.edu	37	3	52382979	52382979	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52382979G>C	uc011bef.1	+	13	2443	c.2182G>C	c.(2182-2184)GAG>CAG	p.E728Q	DNAH1_uc003ddt.1_Missense_Mutation_p.E728Q	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	728	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACTGGTGGAAGAGCTACGGGC	0.592		NaN											0	0	0	1	0	96	123									
NT5DC2	64943	broad.mit.edu	37	3	52561907	52561907	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52561907C>G	uc003deo.2	-	8	1186	c.762G>C	c.(760-762)CTG>CTC	p.L254L	NT5DC2_uc003dem.2_Silent_p.L124L|NT5DC2_uc003den.2_Silent_p.L291L|NT5DC2_uc010hmi.2_Silent_p.L266L|NT5DC2_uc010hmj.2_Silent_p.L70L	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	254							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		CCAGGCGGCTCAGGACAGCAA	0.602		NaN											0	0	0	1	0	49	106									
PBRM1	55193	broad.mit.edu	37	3	52613209	52613209	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52613209C>T	uc003des.2	-	21	3406	c.3394G>A	c.(3394-3396)GAA>AAA	p.E1132K	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E1132K|PBRM1_uc003der.2_Missense_Mutation_p.E1100K|PBRM1_uc003det.2_Missense_Mutation_p.E1147K|PBRM1_uc003deu.2_Missense_Mutation_p.E1147K|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E1132K|PBRM1_uc010hmk.1_Missense_Mutation_p.E1107K|PBRM1_uc003dey.2_Missense_Mutation_p.E1107K|PBRM1_uc003dez.1_Missense_Mutation_p.E1131K	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1132					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.E1132fs*27(1)		kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGGACATCTTCTTTTTCCTGT	0.408		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	56	75									
PBRM1	55193	broad.mit.edu	37	3	52643597	52643597	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52643597C>G	uc003des.2	-	16	2311	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E767Q|PBRM1_uc003der.2_Missense_Mutation_p.E735Q|PBRM1_uc003det.2_Missense_Mutation_p.E782Q|PBRM1_uc003deu.2_Missense_Mutation_p.E782Q|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E767Q|PBRM1_uc010hmk.1_Missense_Mutation_p.E767Q|PBRM1_uc003dey.2_Missense_Mutation_p.E767Q|PBRM1_uc003dez.1_Missense_Mutation_p.E767Q|PBRM1_uc003dfb.1_Missense_Mutation_p.E680Q|PBRM1_uc003dfa.1_Missense_Mutation_p.E113Q|PBRM1_uc003dfc.2_Missense_Mutation_p.E134Q	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	767					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TGAGAGTCCTCATCTCCCTCC	0.438		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	43	25									
ITIH1	3697	broad.mit.edu	37	3	52820325	52820325	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52820325C>A	uc003dfs.2	+	13	1632	c.1608C>A	c.(1606-1608)TTC>TTA	p.F536L	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Missense_Mutation_p.F137L|ITIH1_uc010hmo.1_Missense_Mutation_p.F90L|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	536	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GACAAGAATTCAGTATAACCT	0.582		NaN											1	0	0.0477658	1	0.0478438	6	3									
LRIG1	26018	broad.mit.edu	37	3	66501996	66501996	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:66501996C>T	uc003dmx.2	-	3	366	c.352G>A	c.(352-354)GTC>ATC	p.V118I	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Missense_Mutation_p.V118I	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	118	Extracellular (Potential).|LRR 3.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		AAGAGAGAGACGACATGTGAT	0.483		NaN											0	0	0	1	0	97	227									
OR5H6	79295	broad.mit.edu	37	3	97983819	97983819	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:97983819C>G	uc003dsi.1	+	1	691	c.691C>G	c.(691-693)CTT>GTT	p.L231V		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	231	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TGGAACTATTCTTATATCTTA	0.338		NaN											0	0	0	1	0	21	31									
ABI3BP	25890	broad.mit.edu	37	3	100569525	100569525	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:100569525C>G	uc003dun.2	-	14	1364	c.1279G>C	c.(1279-1281)GAA>CAA	p.E427Q	ABI3BP_uc003duo.2_Missense_Mutation_p.E469Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	427	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						CTTGGCTGTTCAAGAGTTCTA	0.358		NaN											0	0	0	1	0	32	67									
PCNP	57092	broad.mit.edu	37	3	101304305	101304305	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:101304305C>G	uc003dva.2	+	3	322	c.304C>G	c.(304-306)CTT>GTT	p.L102V	PCNP_uc003dvb.2_RNA|PCNP_uc003dvc.2_RNA|PCNP_uc003dvd.2_Missense_Mutation_p.L102V	NM_020357	NP_065090	Q8WW12	PCNP_HUMAN	PEST proteolytic signal containing nuclear	102					cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding				0						TGTTCCAACTCTTGCTCCAAA	0.284		NaN											0	0	0	1	0	61	45									
RPL24	6152	broad.mit.edu	37	3	101399989	101399989	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:101399989C>T	uc003dvh.1	-	6	507	c.464G>A	c.(463-465)GGA>GAA	p.G155E	RPL24_uc003dvi.1_3'UTR	NM_000986	NP_000977	P83731	RL24_HUMAN	ribosomal protein L24	155					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TTAGCGTTTTCCACCAACTCG	0.378		NaN											0	0	0	1	0	151	132									
CCDC54	84692	broad.mit.edu	37	3	107096817	107096817	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:107096817C>G	uc003dwi.1	+	1	630	c.383C>G	c.(382-384)TCT>TGT	p.S128C		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	128	Potential.										0						GATATCCTCTCTATGAAAGAA	0.393		NaN											0	0	0	1	0	29	30									
CD47	961	broad.mit.edu	37	3	107798974	107798974	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:107798974G>A	uc003dwt.1	-	2	444	c.264C>T	c.(262-264)GTC>GTT	p.V88V	CD47_uc003dwu.1_Silent_p.V88V|CD47_uc003dwv.1_Silent_p.V88V|CD47_uc003dww.1_Silent_p.V88V	NM_001777	NP_001768	Q08722	CD47_HUMAN	CD47 antigen isoform 1 precursor	88	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			GTAATTGTGAGACTTCAATTT	0.383		NaN											0	0	0	1	0	62	104									
MYH15	22989	broad.mit.edu	37	3	108163567	108163567	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:108163567C>G	uc003dxa.1	-	23	2692	c.2635G>C	c.(2635-2637)GAG>CAG	p.E879Q		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	879	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CTCTGAAACTCTGATTTCTCC	0.438		NaN											0	0	0	1	0	97	78									
UPK1B	7348	broad.mit.edu	37	3	118906732	118906732	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:118906732G>A	uc003ecc.2	+	3	269	c.180G>A	c.(178-180)TGG>TGA	p.W60*	UPK1B_uc011bix.1_5'UTR|UPK1B_uc003ecd.2_Nonsense_Mutation_p.W60*	NM_006952	NP_008883	O75841	UPK1B_HUMAN	uroplakin 1B	60	Extracellular (Potential).				epithelial cell differentiation	integral to membrane	structural molecule activity				0				GBM - Glioblastoma multiforme(114;0.222)		GGGCTGCCTGGATCGGCATAT	0.517		NaN											0	0	0	1	0	71	153									
POLQ	10721	broad.mit.edu	37	3	121179028	121179028	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:121179028G>A	uc003eee.3	-	25	7150	c.7021C>T	c.(7021-7023)CAT>TAT	p.H2341Y	POLQ_uc003eed.2_Missense_Mutation_p.H1513Y	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2341					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGGGATAAATGAGCCAAGATC	0.428		NaN						DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	72	63									
POLQ	10721	broad.mit.edu	37	3	121187223	121187223	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:121187223G>C	uc003eee.3	-	23	6903	c.6774C>G	c.(6772-6774)ATC>ATG	p.I2258M	POLQ_uc003eed.2_Missense_Mutation_p.I1430M	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2258					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TTGGCATTTTGATTTCAAAAT	0.383		NaN						DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	81	140									
CD86	942	broad.mit.edu	37	3	121822489	121822489	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:121822489G>C	uc003eet.2	+	3	311	c.195G>C	c.(193-195)CTG>CTC	p.L65L	CD86_uc011bjo.1_5'UTR|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Silent_p.L59L	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	65	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	ACTTGGTTCTGAATGAGGTAT	0.438		NaN											0	0	0	1	0	110	108									
ADCY5	111	broad.mit.edu	37	3	123019119	123019119	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:123019119G>A	uc003egh.1	-	15	2748	c.2748C>T	c.(2746-2748)CTC>CTT	p.L916L	ADCY5_uc003egg.1_Silent_p.L549L|ADCY5_uc003egi.1_Silent_p.L475L	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	916	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CCAGCAGGCTGAGCAGCACGC	0.652		NaN											0	0	0	1	0	44	40									
COL6A6	131873	broad.mit.edu	37	3	130287162	130287162	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:130287162G>C	uc010htl.2	+	5	2146	c.2115G>C	c.(2113-2115)CTG>CTC	p.L705L		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	705	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GTAGTGCCCTGAGCTTTGTGT	0.488		NaN											0	0	0	1	0	124	102									
PCOLCE2	26577	broad.mit.edu	37	3	142557645	142557645	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:142557645C>G	uc003evd.2	-	5	873	c.677G>C	c.(676-678)AGA>ACA	p.R226T		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	226	CUB 2.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						CTTTCCAATTCTTCTAGCATC	0.383		NaN											0	0	0	1	0	73	83									
CPA3	1359	broad.mit.edu	37	3	148596271	148596271	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:148596271G>C	uc003ewm.2	+	4	365	c.313G>C	c.(313-315)GAT>CAT	p.D105H		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	105					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GAAACAGTTTGATGTTAAAGA	0.338		NaN											0	0	0	1	0	86	66									
HPS3	84343	broad.mit.edu	37	3	148876575	148876575	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:148876575G>A	uc003ewu.1	+	10	1954	c.1814G>A	c.(1813-1815)GGA>GAA	p.G605E	HPS3_uc011bnq.1_Missense_Mutation_p.G440E|HPS3_uc003ewv.1_5'Flank	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	605						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TACGAGAGAGGATTAATCTTT	0.348		NaN							Hermansky-Pudlak_syndrome				0	0	0	1	0	45	84									
KPNA4	3840	broad.mit.edu	37	3	160253311	160253311	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:160253311G>A	uc003fdn.2	-	5	583	c.277C>T	c.(277-279)CAA>TAA	p.Q93*		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	93	ARM 1; truncated.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			CTAGCAGCTTGAACTGCACTT	0.303		NaN											0	0	0	1	0	31	22									
FNDC3B	64778	broad.mit.edu	37	3	172061902	172061902	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:172061902G>A	uc003fhy.2	+	19	2276	c.2104G>A	c.(2104-2106)GAG>AAG	p.E702K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E702K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	702	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AAGTGGCTGTGAGGTCTCAGA	0.517		NaN											0	0	0	1	0	148	132									
AP2M1	1173	broad.mit.edu	37	3	183898646	183898646	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:183898646G>A	uc011bqx.1	+	6	596	c.439G>A	c.(439-441)GAG>AAG	p.E147K	AP2M1_uc003fmw.2_Missense_Mutation_p.E145K|AP2M1_uc003fmx.2_Missense_Mutation_p.E145K|AP2M1_uc003fmy.2_Missense_Mutation_p.E145K|AP2M1_uc011bqy.1_Missense_Mutation_p.E17K|AP2M1_uc011bqz.1_5'UTR	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	147					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GACAAAAGAAGAGCAGTCACA	0.522		NaN											0	0	0	1	0	238	250									
LEPREL1	55214	broad.mit.edu	37	3	189690804	189690804	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:189690804C>T	uc011bsk.1	-	11	1946	c.1558G>A	c.(1558-1560)GAA>AAA	p.E520K	LEPREL1_uc003fsg.2_Missense_Mutation_p.E339K	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	520					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACTCGACCTTCATAACCAGAC	0.398		NaN											0	0	0	1	0	40	38									
RNF168	165918	broad.mit.edu	37	3	196199142	196199142	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:196199142C>T	uc003fwq.2	-	6	1802	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K	RNF168_uc010iah.2_Missense_Mutation_p.E255K|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	422					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		AAGTTTATTTCTGTTTCCTCT	0.378		NaN											0	0	0	1	0	85	102									
PIGG	54872	broad.mit.edu	37	4	517589	517589	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:517589G>A	uc003gak.3	+	9	2092	c.1956G>A	c.(1954-1956)TGG>TGA	p.W652*	PIGG_uc003gaj.3_Nonsense_Mutation_p.W644*|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Nonsense_Mutation_p.W519*|PIGG_uc003gal.3_Nonsense_Mutation_p.W563*	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	652					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GCGAGAAGTGGATGGTGCTGG	0.657		NaN											0	0	0	1	0	28	15									
WHSC1	7468	broad.mit.edu	37	4	1918624	1918624	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:1918624C>T	uc003gdz.3	+	4	963	c.787C>T	c.(787-789)CAC>TAC	p.H263Y	WHSC1_uc003geb.3_Missense_Mutation_p.H263Y|WHSC1_uc003gec.3_Missense_Mutation_p.H263Y|WHSC1_uc003ged.3_Missense_Mutation_p.H263Y|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.H263Y|WHSC1_uc003gdy.1_Missense_Mutation_p.H263Y|WHSC1_uc010icd.1_Missense_Mutation_p.H263Y|WHSC1_uc003gea.1_Missense_Mutation_p.H263Y|WHSC1_uc010ice.1_Missense_Mutation_p.H263Y|WHSC1_uc003geh.1_Missense_Mutation_p.H263Y	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	263	PWWP 1.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		ACGCCAGTATCACGTACAGTT	0.383		NaN	T	IGH@	MM								0	0	0	1	0	22	27									
HTT	3064	broad.mit.edu	37	4	3208581	3208581	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:3208581C>G	uc011bvq.1	+	45	6097	c.5952C>G	c.(5950-5952)CTC>CTG	p.L1984L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1982					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGATCCATCTCAGCCAGTCGG	0.507		NaN											0	0	0	1	0	49	45									
RGS12	6002	broad.mit.edu	37	4	3432571	3432571	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:3432571G>C	uc003ggw.2	+	17	4907	c.4003G>C	c.(4003-4005)GAG>CAG	p.E1335Q	RGS12_uc003ggv.2_Missense_Mutation_p.E1335Q|RGS12_uc003ggy.1_3'UTR|RGS12_uc003ggz.2_Missense_Mutation_p.E687Q|RGS12_uc011bvs.1_3'UTR|RGS12_uc003gha.2_Missense_Mutation_p.E677Q|RGS12_uc010icv.2_Missense_Mutation_p.E534Q	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1335						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGTGGAGGATGAGCACGTGGC	0.692		NaN											0	0	0	1	0	34	44									
EVC	2121	broad.mit.edu	37	4	5806484	5806484	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:5806484G>A	uc003gil.1	+	17	2661	c.2477G>A	c.(2476-2478)CGG>CAG	p.R826Q	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	826					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TACAAACTGCGGAAAAAGCAA	0.557		NaN											0	0	0	1	0	55	40									
GRPEL1	80273	broad.mit.edu	37	4	7065824	7065824	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:7065824C>A	uc003gjy.1	-	2	230	c.189G>T	c.(187-189)GAG>GAT	p.E63D	GRPEL1_uc003gjz.1_Missense_Mutation_p.E63D	NM_025196	NP_079472	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial precursor	63					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding				0						ACTTGACCTTCTCTTCCAGGA	0.552		NaN											1	0	4.09171e-25	1	4.31707e-25	57	35									
SLC2A9	56606	broad.mit.edu	37	4	9987351	9987351	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:9987351G>A	uc003gmc.2	-	4	538	c.477C>T	c.(475-477)CTC>CTT	p.L159L	SLC2A9_uc003gmd.2_Silent_p.L130L	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	159	Helical; Name=3; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CTCCTGCCTGGAGCGAGCAGG	0.448		NaN											0	0	0	1	0	20	67									
LRRC66	339977	broad.mit.edu	37	4	52861441	52861441	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:52861441C>G	uc003gzi.2	-	4	1760	c.1747G>C	c.(1747-1749)GAA>CAA	p.E583Q		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	583						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GCTGTTATTTCTCCGGAGAGG	0.498		NaN											0	0	0	1	0	41	93									
PDGFRA	5156	broad.mit.edu	37	4	55161411	55161411	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:55161411C>T	uc003han.3	+	23	3573	c.3242C>T	c.(3241-3243)TCA>TTA	p.S1081L	PDGFRA_uc003haa.2_Missense_Mutation_p.S841L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1081	Ser-rich.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ATAGACTCTTCAGACCTGGTG	0.517		NaN	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	1	0	33	100									
EXOC1	55763	broad.mit.edu	37	4	56750054	56750054	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:56750054G>C	uc003hbe.1	+	10	1448	c.1290G>C	c.(1288-1290)AAG>AAC	p.K430N	EXOC1_uc003hbf.1_Missense_Mutation_p.K430N|EXOC1_uc003hbg.1_Missense_Mutation_p.K430N	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	430					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AAGTTGCAAAGATCAAGATGA	0.284		NaN											0	0	0	1	0	20	21									
RUFY3	22902	broad.mit.edu	37	4	71588434	71588434	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:71588434C>G	uc003hfq.2	+	1	739	c.144C>G	c.(142-144)ATC>ATG	p.I48M	RUFY3_uc003hfp.3_Intron|RUFY3_uc011cax.1_Missense_Mutation_p.I48M|RUFY3_uc003hfr.2_Missense_Mutation_p.I48M	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	48					negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TGGATGACATCTCACTTACAC	0.527		NaN											0	0	0	1	0	67	59									
RUFY3	22902	broad.mit.edu	37	4	71634327	71634327	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:71634327G>C	uc003hfq.2	+	5	1240	c.645G>C	c.(643-645)CTG>CTC	p.L215L	RUFY3_uc003hfp.3_Silent_p.L275L|RUFY3_uc011cax.1_Silent_p.L233L|RUFY3_uc003hfr.2_Silent_p.L215L|RUFY3_uc011cay.1_Silent_p.L151L	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	215	RUN.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TGGTGGGTCTGAATGTCATTG	0.438		NaN											0	0	0	1	0	70	69									
FRAS1	80144	broad.mit.edu	37	4	79400752	79400752	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:79400752G>C	uc003hlb.2	+	56	8763	c.8323G>C	c.(8323-8325)GAT>CAT	p.D2775H		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2770	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGCCTTGGCAGATGCCTCTGA	0.527		NaN											0	0	0	1	0	28	49									
HPSE	10855	broad.mit.edu	37	4	84223345	84223345	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:84223345C>T	uc003hoj.3	-	10	1382	c.1283G>A	c.(1282-1284)AGA>AAA	p.R428K	HPSE_uc010ika.2_Missense_Mutation_p.R370K|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.R171K|HPSE_uc011cct.1_Missense_Mutation_p.R354K|HPSE_uc003hok.3_Missense_Mutation_p.R428K	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	428					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	AAGCTTCCTTCTCTTTGAACC	0.423		NaN											0	0	0	1	0	31	61									
SPP1	6696	broad.mit.edu	37	4	88902684	88902684	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:88902684G>T	uc003hra.2	+	6	439	c.274G>T	c.(274-276)GAT>TAT	p.D92Y	SPP1_uc003hrb.2_Missense_Mutation_p.D65Y|SPP1_uc003hrc.2_Missense_Mutation_p.D78Y|SPP1_uc011cde.1_Missense_Mutation_p.D105Y|SPP1_uc003hrd.2_Missense_Mutation_p.D51Y	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	92					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		GGATGATGAAGATGATGATGA	0.428		NaN											1	0	3.41882e-60	1	3.66387e-60	128	91									
FAM190A	401145	broad.mit.edu	37	4	91230191	91230191	+	Silent	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:91230191C>G	uc003hsv.3	+	2	1096	c.756C>G	c.(754-756)ACC>ACG	p.T252T	FAM190A_uc003hsu.3_Silent_p.T252T|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Silent_p.T252T	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	252										large_intestine(1)|ovary(1)	2						CTGATCTTACCACAGCTCAGA	0.438		NaN											0	0	0	1	0	32	57									
PDLIM5	10611	broad.mit.edu	37	4	95583676	95583676	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:95583676C>T	uc003hti.2	+	12	1840	c.1689C>T	c.(1687-1689)TGC>TGT	p.C563C	PDLIM5_uc011cdx.1_Silent_p.C460C|PDLIM5_uc003hth.2_Silent_p.C454C|PDLIM5_uc003htj.2_Silent_p.C238C|PDLIM5_uc003htk.2_Silent_p.C592C|PDLIM5_uc011cdy.1_Silent_p.C441C|PDLIM5_uc003htl.2_Silent_p.C238C	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	563	LIM zinc-binding 3.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		ATGACACTTGCTTTGTATGCT	0.408		NaN											0	0	0	1	0	57	27									
NHEDC1	150159	broad.mit.edu	37	4	103832596	103832596	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:103832596C>T	uc003hww.2	-	8	1050	c.928G>A	c.(928-930)GAA>AAA	p.E310K	NHEDC1_uc003hwu.2_Missense_Mutation_p.E310K|NHEDC1_uc010ilm.2_Missense_Mutation_p.E77K|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_Missense_Mutation_p.E83K	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	310						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		ACCTGGTCTTCACTTGGAAAA	0.299		NaN											0	0	0	1	0	17	34									
DKK2	27123	broad.mit.edu	37	4	107845202	107845202	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:107845202C>T	uc003hyi.2	-	4	1394	c.689G>A	c.(688-690)CGT>CAT	p.R230H	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	230	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		ACAGTCGCAACGCTGGAAAAT	0.488		NaN											0	0	0	1	0	47	100									
SGMS2	166929	broad.mit.edu	37	4	108824404	108824404	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:108824404C>T	uc003hyl.3	+	5	1144	c.589C>T	c.(589-591)CAG>TAG	p.Q197*	uc003hym.1_Intron|SGMS2_uc003hyn.2_Nonsense_Mutation_p.Q197*|SGMS2_uc003hyo.2_Nonsense_Mutation_p.Q197*	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	197					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TGGAGACTCTCAGGCAAAAGT	0.408		NaN											0	0	0	1	0	49	133									
NDST4	64579	broad.mit.edu	37	4	115750948	115750948	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:115750948C>G	uc003ibu.2	-	13	3176	c.2497G>C	c.(2497-2499)GAG>CAG	p.E833Q	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	833	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATTATTACCTCTGGATCCATA	0.343		NaN											0	0	0	1	0	32	13									
EXOSC9	5393	broad.mit.edu	37	4	122737544	122737544	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:122737544G>C	uc003iea.2	+	11	1285	c.1177G>C	c.(1177-1179)GAT>CAT	p.D393H	EXOSC9_uc003idz.2_Missense_Mutation_p.D410H|EXOSC9_uc003ieb.2_Missense_Mutation_p.D377H	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	393					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						AATACTCTCAGATAGTGAAGA	0.244		NaN											0	0	0	1	0	14	36									
MFSD8	256471	broad.mit.edu	37	4	128878746	128878746	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:128878746C>G	uc003ifp.2	-	3	227	c.64G>C	c.(64-66)GAA>CAA	p.E22Q	MFSD8_uc011cgu.1_5'UTR|MFSD8_uc011cgv.1_Missense_Mutation_p.E22Q|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_5'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	22	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						ATGTCCCATTCTCTAGGTGTA	0.308		NaN											0	0	0	1	0	59	55									
GUCY1B3	2983	broad.mit.edu	37	4	156726374	156726374	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:156726374G>C	uc003ipc.2	+	13	1996	c.1829G>C	c.(1828-1830)GGA>GCA	p.G610A	GUCY1B3_uc011cio.1_Missense_Mutation_p.G632A|GUCY1B3_uc011cip.1_Missense_Mutation_p.G590A|GUCY1B3_uc003ipd.2_Missense_Mutation_p.G538A|GUCY1B3_uc010iqf.2_Missense_Mutation_p.G577A|GUCY1B3_uc010iqg.2_Missense_Mutation_p.G581A|GUCY1B3_uc011ciq.1_Missense_Mutation_p.G538A	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	610					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAAAATACAGGAACAGAGGTA	0.358		NaN											0	0	0	1	0	11	2									
DDX60	55601	broad.mit.edu	37	4	169204637	169204637	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:169204637G>C	uc003irp.2	-	13	1974	c.1682C>G	c.(1681-1683)TCA>TGA	p.S561*		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	561							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		ATCCTTCTTTGACTTAATAGT	0.333		NaN											0	0	0	1	0	28	25									
SH3RF1	57630	broad.mit.edu	37	4	170028027	170028027	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:170028027C>G	uc003isa.1	-	11	2804	c.2469G>C	c.(2467-2469)TTG>TTC	p.L823F		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	823						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TAGACTCATTCAAGACAGGAC	0.483		NaN											0	0	0	1	0	61	54									
ADCY2	108	broad.mit.edu	37	5	7414837	7414837	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:7414837G>T	uc003jdz.1	+	2	429	c.362G>T	c.(361-363)GGA>GTA	p.G121V		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	121	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GTTGCCATGGGATACCTGTTC	0.428		NaN											1	0	8.16721e-17	1	8.45692e-17	33	31									
SEMA5A	9037	broad.mit.edu	37	5	9066645	9066645	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:9066645G>C	uc003jek.2	-	17	2899	c.2187C>G	c.(2185-2187)TTC>TTG	p.F729L		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	729	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ATGTGTATCGGAATCGTTGCT	0.557		NaN											0	0	0	1	0	129	79									
MYO10	4651	broad.mit.edu	37	5	16668556	16668556	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:16668556G>A	uc003jft.3	-	40	6373	c.5905C>T	c.(5905-5907)CAG>TAG	p.Q1969*	MYO10_uc011cnb.1_Nonsense_Mutation_p.Q598*|MYO10_uc011cnc.1_Nonsense_Mutation_p.Q848*|MYO10_uc011cnd.1_Nonsense_Mutation_p.Q1326*|MYO10_uc011cne.1_Nonsense_Mutation_p.Q1326*|MYO10_uc010itx.2_Nonsense_Mutation_p.Q1591*	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1969	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CAGAGTTCCTGAGGGAAGCCA	0.512		NaN											0	0	0	1	0	15	9									
OSMR	9180	broad.mit.edu	37	5	38884065	38884065	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:38884065G>A	uc003jln.1	+	5	922	c.555G>A	c.(553-555)CAG>CAA	p.Q185Q	OSMR_uc003jlm.1_Silent_p.Q185Q	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	185	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					AAGGGAAACAGATTCATGGAG	0.373		NaN											0	0	0	1	0	62	27									
PAIP1	10605	broad.mit.edu	37	5	43543211	43543211	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:43543211G>C	uc003job.2	-	4	876	c.629C>G	c.(628-630)TCT>TGT	p.S210C	PAIP1_uc003joa.2_Missense_Mutation_p.S131C|PAIP1_uc010ivp.2_Missense_Mutation_p.S131C|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.S98C	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	210	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATTTGGGATAGATGTGGCCTT	0.358		NaN											0	0	0	1	0	22	17									
C5orf35	133383	broad.mit.edu	37	5	56207012	56207012	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:56207012C>G	uc003jqx.2	+	2	488	c.115C>G	c.(115-117)CCA>GCA	p.P39A	C5orf35_uc003jqy.2_Intron	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	39										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		CCGATATGTTCCAGAGGAATC	0.383		NaN											0	0	0	1	0	41	23									
MAST4	375449	broad.mit.edu	37	5	66459046	66459046	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:66459046C>G	uc003jut.1	+	28	3540	c.3472C>G	c.(3472-3474)CGG>GGG	p.R1158G	MAST4_uc003juw.2_Missense_Mutation_p.R1086G|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1350						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CGGGCACATCCGGCCCAGCAC	0.632		NaN											0	0	0	1	0	66	255									
BDP1	55814	broad.mit.edu	37	5	70855922	70855922	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:70855922C>T	uc003kbp.1	+	37	7617	c.7354C>T	c.(7354-7356)CCT>TCT	p.P2452S	BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2452					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATCTAGATCTCCTGATGCATG	0.438		NaN											0	0	0	1	0	49	34									
TNPO1	3842	broad.mit.edu	37	5	72188999	72188999	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:72188999G>A	uc003kck.3	+	16	1969	c.1822G>A	c.(1822-1824)GGA>AGA	p.G608R	TNPO1_uc011csj.1_Missense_Mutation_p.G558R|TNPO1_uc003kch.2_Missense_Mutation_p.G600R|TNPO1_uc003kci.3_Missense_Mutation_p.G600R|TNPO1_uc003kcg.3_Missense_Mutation_p.G600R	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	608					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		ACTGCAGTCTGGATTCCTTCC	0.398		NaN											0	0	0	1	0	46	140									
THBS4	7060	broad.mit.edu	37	5	79366148	79366148	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:79366148G>C	uc003kgh.2	+	12	1690	c.1367G>C	c.(1366-1368)GGA>GCA	p.G456A	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	456	EGF-like 4.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GGTTGGGCTGGAGATGGCTAT	0.562		NaN											0	0	0	1	0	15	76									
MSH3	4437	broad.mit.edu	37	5	80150118	80150118	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:80150118G>C	uc003kgz.2	+	21	3236	c.2983G>C	c.(2983-2985)GAG>CAG	p.E995Q		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	995					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		TGCTACACTTGAGTATTTCAT	0.289		NaN						MMR					0	0	0	1	0	35	106									
RASGRF2	5924	broad.mit.edu	37	5	80422972	80422972	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:80422972G>C	uc003kha.1	+	17	2676	c.2676G>C	c.(2674-2676)GGG>GGC	p.G892G	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	892					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CAGGACATGGGAGTCCACCAG	0.493		NaN											0	0	0	1	0	17	53									
CETN3	1070	broad.mit.edu	37	5	89701566	89701566	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:89701566C>G	uc003kjo.2	-	3	329	c.204G>C	c.(202-204)AAG>AAC	p.K68N		NM_004365	NP_004356	O15182	CETN3_HUMAN	centrin 3	68	EF-hand 2.				cell division|centrosome cycle|mitosis	centriole	calcium ion binding				0		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		CTTTAAGAATCTTCAGTACAT	0.338		NaN											0	0	0	1	0	38	35									
GPR98	84059	broad.mit.edu	37	5	89943435	89943435	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:89943435G>A	uc003kju.2	+	17	3239	c.3143G>A	c.(3142-3144)AGA>AAA	p.R1048K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1048	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCTACTGCAAGAGAGAGAGAT	0.423		NaN											0	0	0	1	0	36	92									
FAM170A	340069	broad.mit.edu	37	5	118965403	118965403	+	Translation_Start_Site	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:118965403C>G	uc003ksm.2	+	1	150	c.-60C>G	c.(-62--58)ATCTA>ATGTA		FAM170A_uc003ksl.2_Translation_Start_Site|FAM170A_uc003ksn.2_Translation_Start_Site|FAM170A_uc003kso.2_Translation_Start_Site	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A							intracellular	zinc ion binding			skin(1)	1						AAGGGCCAATCTACAGGAAAA	0.398		NaN											0	0	0	1	0	25	26									
LMNB1	4001	broad.mit.edu	37	5	126147468	126147468	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:126147468G>C	uc003kud.1	+	5	1185	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	LMNB1_uc003kuc.2_Missense_Mutation_p.E273Q|LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Missense_Mutation_p.E63Q	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	273	Rod.|Coil 2.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		CTTTTAGCTTGAGAATGCCAG	0.423		NaN											0	0	0	1	0	30	28									
AFF4	27125	broad.mit.edu	37	5	132270097	132270097	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:132270097C>A	uc003kyd.2	-	3	1068	c.660G>T	c.(658-660)TGG>TGT	p.W220C	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.W220C|AFF4_uc003kyf.3_Missense_Mutation_p.W220C	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	220	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGGAGAATCCCAGTTTGCAT	0.448		NaN											1	0	9.17885e-22	1	9.56911e-22	33	49									
PCDHA5	56143	broad.mit.edu	37	5	140202695	140202695	+	Silent	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:140202695C>A	uc003lhl.2	+	1	1335	c.1335C>A	c.(1333-1335)GCC>GCA	p.A445A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.A445A|PCDHA5_uc003lhj.1_Silent_p.A445A	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	445	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAGTGGCCGACGTGAACG	0.657		NaN											1	0	4.21487e-37	1	4.48562e-37	89	71									
PCDHB13	56123	broad.mit.edu	37	5	140595757	140595757	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:140595757G>A	uc003lja.1	+	1	2249	c.2062G>A	c.(2062-2064)GTC>ATC	p.V688I		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	688	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTGCTCACCGTCTACCTGGT	0.687		NaN											0	0	0	1	0	89	168									
FAT2	2196	broad.mit.edu	37	5	150934193	150934193	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:150934193G>A	uc003lue.3	-	4	3688	c.3675C>T	c.(3673-3675)ACC>ACT	p.T1225T	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1225	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCACCCTGGAGGTGGACTTCA	0.517		NaN											0	0	0	1	0	37	99									
GEMIN5	25929	broad.mit.edu	37	5	154267890	154267890	+	Silent	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:154267890G>T	uc003lvx.3	-	28	4490	c.4407C>A	c.(4405-4407)CTC>CTA	p.L1469L	GEMIN5_uc011ddk.1_Silent_p.L1468L	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1469					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGGACCTGATGAGAAGCAGGA	0.527		NaN											1	0	9.16793e-09	1	9.31997e-09	16	59									
ODZ2	57451	broad.mit.edu	37	5	167631499	167631499	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:167631499G>A	uc010jjd.2	+	19	3670	c.3670G>A	c.(3670-3672)GAA>AAA	p.E1224K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1001K|ODZ2_uc003lzt.3_Missense_Mutation_p.E597K|ODZ2_uc010jje.2_Missense_Mutation_p.E495K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CGGCCTTGCTGAAGGCAACAA	0.577		NaN											0	0	0	1	0	18	42									
DOCK2	1794	broad.mit.edu	37	5	169502984	169502984	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:169502984G>A	uc003maf.2	+	47	4842	c.4762G>A	c.(4762-4764)GAG>AAG	p.E1588K	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E1080K|DOCK2_uc003mah.2_Missense_Mutation_p.E144K	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1588	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAAGATCCATGAGAAAAGGGT	0.532		NaN											0	0	0	1	0	40	118									
NKX2-5	1482	broad.mit.edu	37	5	172660109	172660109	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:172660109C>T	uc003mcm.1	-	2	614	c.438G>A	c.(436-438)TCG>TCA	p.S146S	NKX2-5_uc011dfe.1_3'UTR|NKX2-5_uc010jjt.1_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	146	Homeobox.				adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCTGCGCCTGCGAGAAGAGCA	0.692		NaN											0	0	0	1	0	8	5									
CPEB4	80315	broad.mit.edu	37	5	173316947	173316947	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:173316947C>G	uc003mcs.3	+	1	1617	c.211C>G	c.(211-213)CAG>GAG	p.Q71E	CPEB4_uc010jju.1_Missense_Mutation_p.Q71E|CPEB4_uc010jjv.2_Missense_Mutation_p.Q71E|CPEB4_uc011dfg.1_Missense_Mutation_p.Q71E	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	71							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCATAACATTCAGGATGAGAT	0.498		NaN											0	0	0	1	0	111	83									
CANX	821	broad.mit.edu	37	5	179143168	179143168	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:179143168C>T	uc003mkk.2	+	8	961	c.784C>T	c.(784-786)CTG>TTG	p.L262L	CANX_uc011dgp.1_Silent_p.L297L|CANX_uc010jlb.1_Silent_p.L198L|CANX_uc003mkl.2_Silent_p.L262L|CANX_uc011dgq.1_Silent_p.L154L	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	262	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGTGGAAATCTGCTCAATGA	0.388		NaN											0	0	0	1	0	61	57									
HIVEP1	3096	broad.mit.edu	37	6	12122571	12122571	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12122571C>T	uc003nac.2	+	4	2722	c.2543C>T	c.(2542-2544)TCA>TTA	p.S848L	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	848					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACAGGTTATTCAGCAGTACCT	0.398		NaN											0	0	0	1	0	39	107									
HIVEP1	3096	broad.mit.edu	37	6	12122603	12122603	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12122603C>T	uc003nac.2	+	4	2754	c.2575C>T	c.(2575-2577)CAT>TAT	p.H859Y	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	859					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACCTCCTCCTCATCCACTAAG	0.443		NaN											0	0	0	1	0	36	91									
HIVEP1	3096	broad.mit.edu	37	6	12122781	12122781	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12122781C>G	uc003nac.2	+	4	2932	c.2753C>G	c.(2752-2754)TCC>TGC	p.S918C	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	918					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACTGGACAGTCCCTGGATGAG	0.517		NaN											0	0	0	1	0	10	33									
HIVEP1	3096	broad.mit.edu	37	6	12123600	12123600	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12123600C>T	uc003nac.2	+	4	3751	c.3572C>T	c.(3571-3573)TCT>TTT	p.S1191F	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1191					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CGGGACGGGTCTCATCCTCAC	0.512		NaN											0	0	0	1	0	3	30									
HIVEP1	3096	broad.mit.edu	37	6	12123624	12123624	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12123624C>G	uc003nac.2	+	4	3775	c.3596C>G	c.(3595-3597)TCA>TGA	p.S1199*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1199					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTTGCACTATCAGACGCTCTC	0.512		NaN											0	0	0	1	0	4	31									
HIVEP1	3096	broad.mit.edu	37	6	12123634	12123634	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12123634C>T	uc003nac.2	+	4	3785	c.3606C>T	c.(3604-3606)CTC>CTT	p.L1202L	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1202					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CAGACGCTCTCAGAGGAGAAC	0.517		NaN											0	0	0	1	0	3	34									
RNF182	221687	broad.mit.edu	37	6	13977385	13977385	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:13977385C>G	uc003nbe.2	+	3	453	c.35C>G	c.(34-36)TCT>TGT	p.S12C	RNF182_uc003nbf.2_Missense_Mutation_p.S12C|RNF182_uc003nbg.2_Missense_Mutation_p.S12C	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	12						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			ACTGCGGAGTCTCAGGCCTCT	0.468		NaN											0	0	0	1	0	45	100									
KIF13A	63971	broad.mit.edu	37	6	17771434	17771434	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:17771434G>C	uc003ncg.3	-	38	4597	c.4492C>G	c.(4492-4494)CAG>GAG	p.Q1498E	KIF13A_uc003ncf.2_Intron|KIF13A_uc003nch.3_Intron|KIF13A_uc003nci.3_Intron|KIF13A_uc003nce.1_Intron	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1498					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTATGTGCCTGAGGTGGAGGC	0.458		NaN											0	0	0	1	0	8	17									
LRRC16A	55604	broad.mit.edu	37	6	25619782	25619782	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:25619782G>A	uc011djw.1	+	37	4463	c.4087G>A	c.(4087-4089)GAA>AAA	p.E1363K	LRRC16A_uc010jpx.2_Missense_Mutation_p.E1318K|LRRC16A_uc010jpy.2_Missense_Mutation_p.E1357K	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1363					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CTCCGGGGAAGAAGCAGAAAA	0.498		NaN											0	0	0	1	0	62	45									
ZNF322A	79692	broad.mit.edu	37	6	26637743	26637743	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:26637743C>G	uc003nil.3	-	4	1668	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	ZNF322A_uc003nij.2_5'Flank	NM_024639	NP_078915	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322A	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0						TGTAGCTCCTCTGTTTGAGTT	0.428		NaN											0	0	0	1	0	63	101									
FKSG83	83954	broad.mit.edu	37	6	27293278	27293278	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:27293278C>G	uc010jqt.2	+	1	701	c.217C>G	c.(217-219)CAT>GAT	p.H73D	FKSG83_uc010jqs.1_3'UTR	NM_032030	NP_114419	Q3KNW7	Q3KNW7_HUMAN	FKSG83	73						integral to membrane	pheromone receptor activity				0						GACGGTCTTTCATATTCACAG	0.398		NaN											0	0	0	1	0	72	67									
GNL1	2794	broad.mit.edu	37	6	30514513	30514513	+	Silent	SNP	G	G	A	rs5875262		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:30514513G>A	uc003nqh.2	-	11	2570	c.1542C>T	c.(1540-1542)CTC>CTT	p.L514L	GNL1_uc011dmi.1_Silent_p.L311L|GNL1_uc011dmj.1_Silent_p.L512L|GNL1_uc011dmk.1_Silent_p.L169L	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	514				L -> V (in Ref. 1; AAA66492).	response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						AACACAGGCTGAGGCGGCCGT	0.507		NaN											0	0	0	1	0	28	83									
MDC1	9656	broad.mit.edu	37	6	30672146	30672146	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:30672146G>C	uc003nrg.3	-	10	5254	c.4814C>G	c.(4813-4815)TCT>TGT	p.S1605C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S1212C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1605	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GGTCTTGACAGAGGACCTATT	0.602		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	1	0	91	86									
MDC1	9656	broad.mit.edu	37	6	30673848	30673848	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:30673848G>C	uc003nrg.3	-	10	3552	c.3112C>G	c.(3112-3114)CTG>GTG	p.L1038V	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.L645V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1038	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GTAGGAGGCAGACAAGCATCT	0.517		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	1	0	41	35									
BAT5	7920	broad.mit.edu	37	6	31669889	31669889	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:31669889G>A	uc003nvy.1	-	2	181	c.151C>T	c.(151-153)CGT>TGT	p.R51C	BAT5_uc003nvx.1_5'UTR|BAT5_uc011dny.1_Intron|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_5'UTR|BAT5_uc010jtc.1_Intron|BAT5_uc011doa.1_5'UTR	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	51						integral to membrane	hydrolase activity|protein binding				0						TCCAGGGCACGGGGCTGATAG	0.547		NaN											0	0	0	1	0	19	54									
TNXB	7148	broad.mit.edu	37	6	32046817	32046817	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:32046817G>A	uc003nzl.2	-	11	4570	c.4368C>T	c.(4366-4368)GGC>GGT	p.G1456G		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1543					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CACCTGTCACGCCCACGGCGG	0.662		NaN											0	0	0	1	0	47	27									
HLA-DOA	3111	broad.mit.edu	37	6	32977305	32977305	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:32977305G>C	uc003ocr.2	-	1	85	c.9C>G	c.(7-9)CTC>CTG	p.L3L	HLA-DOA_uc010juj.2_5'UTR|HLA-DOA_uc010jui.2_Silent_p.L3L	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	3					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GCCCTGCTCTGAGGGCCATTA	0.587		NaN											0	0	0	1	0	5	12									
ANKS1A	23294	broad.mit.edu	37	6	34985275	34985275	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:34985275G>C	uc003ojx.3	+	11	1591	c.1449G>C	c.(1447-1449)CGG>CGC	p.R483R	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Silent_p.R23R|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	483						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						GCAGCAGCCGGAGCCAGGACT	0.592		NaN											0	0	0	1	0	70	54									
MAPK14	1432	broad.mit.edu	37	6	36020527	36020527	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:36020527C>T	uc003olp.2	+	2	649	c.168C>T	c.(166-168)TCC>TCT	p.S56S	MAPK14_uc011dth.1_Silent_p.S56S|MAPK14_uc003olo.2_Silent_p.S56S|MAPK14_uc003olq.2_Silent_p.S56S|MAPK14_uc003olr.2_Silent_p.S56S|MAPK14_uc011dti.1_5'UTR	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	56	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						AGAAGCTCTCCAGACCATTTC	0.383		NaN											0	0	0	1	0	32	93									
PPIL1	51645	broad.mit.edu	37	6	36823787	36823787	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:36823787G>A	uc003omu.2	-	4	555	c.303C>T	c.(301-303)GCC>GCT	p.A101A		NM_016059	NP_057143	Q9Y3C6	PPIL1_HUMAN	peptidylprolyl isomerase-like 1	101	PPIase cyclophilin-type.|Cyclosporin A binding.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GCCCCGCATTGGCCATTGCGA	0.552		NaN											0	0	0	1	0	23	23									
LRFN2	57497	broad.mit.edu	37	6	40399707	40399707	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:40399707G>C	uc003oph.1	-	2	1611	c.1146C>G	c.(1144-1146)CTC>CTG	p.L382L		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	382	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCTGTTGCTGAGGTGTGGCA	0.652		NaN											0	0	0	1	0	23	50									
PRPH2	5961	broad.mit.edu	37	6	42689881	42689881	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:42689881C>G	uc003osk.2	-	1	478	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	64	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CCATCCCTATCAATGAGTTGG	0.517		NaN											0	0	0	1	0	78	70									
ME1	4199	broad.mit.edu	37	6	84108173	84108173	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:84108173G>C	uc003pjy.2	-	3	381	c.275C>G	c.(274-276)TCT>TGT	p.S92C	ME1_uc011dzb.1_Missense_Mutation_p.S17C|ME1_uc011dzc.1_Intron	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	92					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	CTCAATGTCAGATGTCAGCAC	0.363		NaN											0	0	0	1	0	14	54									
MDN1	23195	broad.mit.edu	37	6	90425454	90425454	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:90425454C>G	uc003pnn.1	-	45	6894	c.6778G>C	c.(6778-6780)GAA>CAA	p.E2260Q		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2260					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCTCCGGGTTCAAGCAAAGCA	0.448		NaN											0	0	0	1	0	28	107									
PREP	5550	broad.mit.edu	37	6	105825294	105825294	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:105825294G>A	uc003prc.2	-	3	424	c.221C>T	c.(220-222)CCC>CTC	p.P74L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	74					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ACTATACTTGGGATAATCATA	0.358		NaN											0	0	0	1	0	29	106									
MARCKS	4082	broad.mit.edu	37	6	114181750	114181750	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:114181750G>C	uc003pvy.3	+	2	1389	c.994G>C	c.(994-996)GAG>CAG	p.E332Q		NM_002356	NP_002347	P29966	MARCS_HUMAN	myristoylated alanine-rich protein kinase C	332					energy reserve metabolic process|regulation of insulin secretion	actin cytoskeleton|plasma membrane	actin filament binding|calmodulin binding				0		all_cancers(87;7.65e-05)|all_epithelial(87;0.000296)|all_hematologic(75;0.0172)|Colorectal(196;0.0317)|all_lung(197;0.198)		Epithelial(106;1.59e-07)|all cancers(137;9.85e-07)|OV - Ovarian serous cystadenocarcinoma(136;0.000322)		GGAGGCGGCAGAGTAAAAGAG	0.597		NaN											0	0	0	1	0	73	53									
PLN	5350	broad.mit.edu	37	6	118880088	118880088	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:118880088G>C	uc003pye.2	+	2	215	c.4G>C	c.(4-6)GAG>CAG	p.E2Q	C6orf204_uc003pxz.1_Intron|C6orf204_uc003pya.1_Intron|C6orf204_uc003pyb.2_Intron|C6orf204_uc011ebj.1_Intron|C6orf204_uc003pyc.2_Intron	NM_002667	NP_002658	P26678	PPLA_HUMAN	phospholamban	2	Cytoplasmic (Potential).				blood circulation|regulation of calcium ion transport	integral to membrane|mitochondrial membrane|sarcoplasmic reticulum	calcium channel regulator activity|protein binding				0		all_cancers(87;0.0916)|all_epithelial(87;0.131)		GBM - Glioblastoma multiforme(226;0.0325)|all cancers(137;0.154)|OV - Ovarian serous cystadenocarcinoma(136;0.176)		TGGTATCATGGAGAAAGTCCA	0.403		NaN											0	0	0	1	0	17	17									
PTPRK	5796	broad.mit.edu	37	6	128318060	128318060	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:128318060C>A	uc003qbk.2	-	17	3117	c.2750G>T	c.(2749-2751)GGA>GTA	p.G917V	PTPRK_uc003qbj.2_Missense_Mutation_p.G918V|PTPRK_uc010kfc.2_Missense_Mutation_p.G918V|PTPRK_uc011ebu.1_Missense_Mutation_p.G934V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	917	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TATAATGTTTCCATATCGGTT	0.333		NaN											1	0	0.0135373	1	0.0135816	9	19									
HIVEP2	3097	broad.mit.edu	37	6	143095470	143095470	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:143095470C>T	uc003qjd.2	-	5	1149	c.406G>A	c.(406-408)GAG>AAG	p.E136K		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AATAAGTCCTCAGAGGCAACG	0.502		NaN											0	0	0	1	0	77	71									
UTRN	7402	broad.mit.edu	37	6	145051568	145051568	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:145051568G>A	uc003qkt.2	+	53	7977	c.7885G>A	c.(7885-7887)GAT>AAT	p.D2629N		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2629	Spectrin 18.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTTCTTGGCTGATCAGCCAAT	0.448		NaN											0	0	0	1	0	19	39									
RAET1E	135250	broad.mit.edu	37	6	150210659	150210659	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:150210659G>C	uc003qnl.1	-	3	507	c.447C>G	c.(445-447)CTC>CTG	p.L149L	uc003qni.1_Intron|RAET1E_uc003qnj.2_Silent_p.L149L|RAET1E_uc003qnk.1_Silent_p.L113L|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	149	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TTGCGTCAAAGAGGAGGGATT	0.468		NaN											0	0	0	1	0	84	69									
ARID1B	57492	broad.mit.edu	37	6	157256700	157256700	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:157256700C>G	uc003qqn.2	+	4	1966	c.1814C>G	c.(1813-1815)TCA>TGA	p.S605*	ARID1B_uc003qqo.2_Nonsense_Mutation_p.S618*|ARID1B_uc003qqp.2_Nonsense_Mutation_p.S605*|ARID1B_uc003qqq.1_Nonsense_Mutation_p.S33*	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	663					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GAAAGACCATCAAGTTTACCA	0.373		NaN											0	0	0	1	0	17	58									
SUN1	23353	broad.mit.edu	37	7	872165	872165	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:872165G>C	uc011jvp.1	+	2	83	c.4G>C	c.(4-6)GAT>CAT	p.D2H	SUN1_uc010ksa.1_Missense_Mutation_p.D23H|SUN1_uc003sje.1_Missense_Mutation_p.D2H|SUN1_uc003sjf.2_Intron|SUN1_uc011jvq.1_Missense_Mutation_p.D2H	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	2	Nuclear.|LMNA-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GGTGAACATGGATTTTTCTCG	0.537		NaN											0	0	0	1	0	12	17									
SUN1	23353	broad.mit.edu	37	7	872210	872210	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:872210G>C	uc011jvp.1	+	2	128	c.49G>C	c.(49-51)GAG>CAG	p.E17Q	SUN1_uc010ksa.1_Missense_Mutation_p.E38Q|SUN1_uc003sje.1_Missense_Mutation_p.E17Q|SUN1_uc003sjf.2_Intron|SUN1_uc011jvq.1_Missense_Mutation_p.E17Q	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	17	Nuclear.|LMNA-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GTGTGTGCCGGAGAACACGGG	0.562		NaN											0	0	0	1	0	9	16									
HDAC9	9734	broad.mit.edu	37	7	18767220	18767220	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:18767220G>A	uc003suh.2	+	12	1781	c.1740G>A	c.(1738-1740)ACG>ACA	p.T580T	HDAC9_uc003sue.2_Silent_p.T580T|HDAC9_uc011jyd.1_Silent_p.T580T|HDAC9_uc003sui.2_Silent_p.T583T|HDAC9_uc003suj.2_Silent_p.T539T|HDAC9_uc003sua.1_Silent_p.T558T|HDAC9_uc010kue.1_Silent_p.T235T	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	580					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGAACCCACGCACACACGTG	0.527		NaN											0	0	0	1	0	4	14									
ABCB5	340273	broad.mit.edu	37	7	20766683	20766683	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:20766683G>C	uc003suw.3	+	13	1857	c.1311G>C	c.(1309-1311)GAG>GAC	p.E437D	ABCB5_uc010kuh.2_Missense_Mutation_p.E882D|ABCB5_uc003sux.1_Missense_Mutation_p.E60D	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	437	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AAGCTTTGGAGAATATACGTA	0.328		NaN											0	0	0	1	0	33	48									
STK31	56164	broad.mit.edu	37	7	23821065	23821065	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:23821065G>C	uc003sws.3	+	16	2060	c.1993G>C	c.(1993-1995)GAG>CAG	p.E665Q	STK31_uc003swt.3_Missense_Mutation_p.E642Q|STK31_uc011jze.1_Missense_Mutation_p.E665Q|STK31_uc010kuq.2_Missense_Mutation_p.E642Q	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	665							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CTCTCAAATTGAGAAAATAAA	0.299		NaN											0	0	0	1	0	20	43									
VPS41	27072	broad.mit.edu	37	7	38860835	38860835	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:38860835C>G	uc003tgy.2	-	6	378	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	VPS41_uc003tgz.2_Missense_Mutation_p.E93Q|VPS41_uc010kxn.2_Missense_Mutation_p.E118Q	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	118					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TCGTGAAATTCTTCTCCAGAA	0.368		NaN											0	0	0	1	0	75	102									
POLM	27434	broad.mit.edu	37	7	44119193	44119193	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:44119193C>G	uc003tjt.2	-	4	711	c.619G>C	c.(619-621)GAA>CAA	p.E207Q	POLM_uc003tjw.1_5'Flank|POLM_uc003tju.2_Missense_Mutation_p.E207Q|POLM_uc003tjx.2_Missense_Mutation_p.E207Q|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Intron|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Missense_Mutation_p.E207Q|POLM_uc011kbu.1_Missense_Mutation_p.E174Q|POLM_uc010kxy.2_Missense_Mutation_p.E207Q	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	207					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						GAGGAGTGTTCTCCAAAGTGG	0.637		NaN						DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	42	67									
CCM2	83605	broad.mit.edu	37	7	45115443	45115443	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:45115443G>A	uc003tmo.2	+	10	1268	c.1122G>A	c.(1120-1122)GTG>GTA	p.V374V	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Silent_p.V316V|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Silent_p.V283V|CCM2_uc003tms.2_Silent_p.V395V	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	374					endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						CCATTGGCGTGAAGGATGGCC	0.612		NaN							Familial_Cerebral_Cavernous_Angioma				0	0	0	1	0	54	59									
CLIP2	7461	broad.mit.edu	37	7	73790516	73790516	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:73790516G>A	uc003uam.2	+	10	2112	c.1785G>A	c.(1783-1785)CTG>CTA	p.L595L	CLIP2_uc003uan.2_Silent_p.L560L|CLIP2_uc003uao.2_5'UTR	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	595	Potential.					microtubule associated complex				skin(3)	3						TGGCGGGCCTGAAGGACAAGG	0.612		NaN											0	0	0	1	0	26	26									
AKAP9	10142	broad.mit.edu	37	7	91709233	91709233	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:91709233G>A	uc003ulg.2	+	31	8011	c.7786G>A	c.(7786-7788)GAG>AAG	p.E2596K	AKAP9_uc003ulf.2_Missense_Mutation_p.E2588K|AKAP9_uc003uli.2_Missense_Mutation_p.E2219K|AKAP9_uc003ulj.2_Missense_Mutation_p.E366K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2608	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAGAGAAGATGAGTTGGGGTC	0.318		NaN	T	BRAF	papillary thyroid								0	0	0	1	0	50	39									
HEPACAM2	253012	broad.mit.edu	37	7	92838029	92838029	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:92838029G>A	uc003umm.2	-	4	899	c.876C>T	c.(874-876)ATC>ATT	p.I292I	HEPACAM2_uc003uml.2_Silent_p.I280I|HEPACAM2_uc010lff.2_Silent_p.I280I|HEPACAM2_uc011khy.1_Silent_p.I315I	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	292	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CATGCTTAATGATATATGTAG	0.463		NaN											0	0	0	1	0	37	59									
CCDC132	55610	broad.mit.edu	37	7	92921129	92921129	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:92921129G>A	uc003umo.2	+	13	1185	c.1057G>A	c.(1057-1059)GAT>AAT	p.D353N	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.D323N|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.D73N	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	353											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TGACAATGAGGATACTGCTTC	0.368		NaN											0	0	0	1	0	33	40									
PON2	5445	broad.mit.edu	37	7	95039303	95039303	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:95039303G>A	uc003unv.2	-	6	726	c.605C>T	c.(604-606)GCA>GTA	p.A202V	PON2_uc003unu.2_Missense_Mutation_p.A190V|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Missense_Mutation_p.A115V	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	202					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			AACAACATTTGCCCAGTGTAA	0.388		NaN											0	0	0	1	0	66	94									
SMURF1	57154	broad.mit.edu	37	7	98634777	98634777	+	Silent	SNP	G	G	A	rs148999069	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:98634777G>A	uc003upu.1	-	16	2120	c.1800C>T	c.(1798-1800)ATC>ATT	p.I600I	SMURF1_uc003upv.1_Silent_p.I574I|SMURF1_uc003upt.2_Silent_p.I574I	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	600	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			ACTGGGCTTCGATTCCTCTCA	0.468		NaN									OREG0018188	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	52	79									
PUS7	54517	broad.mit.edu	37	7	105111175	105111175	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:105111175G>C	uc003vcx.2	-	11	1577	c.1358C>G	c.(1357-1359)TCA>TGA	p.S453*	PUS7_uc010lji.2_Nonsense_Mutation_p.S459*|PUS7_uc003vcy.2_Nonsense_Mutation_p.S453*|PUS7_uc003vcz.1_Nonsense_Mutation_p.S453*	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	453	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TCCATATTTTGAAAGTCCTCG	0.423		NaN											0	0	0	1	0	92	109									
LAMB4	22798	broad.mit.edu	37	7	107689947	107689947	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:107689947G>A	uc010ljo.1	-	27	4030	c.3946C>T	c.(3946-3948)CAC>TAC	p.H1316Y	LAMB4_uc003vey.2_Missense_Mutation_p.H1316Y|LAMB4_uc010ljp.1_Missense_Mutation_p.H285Y	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1316	Domain II.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GATGATATGTGATAATATTTC	0.284		NaN											0	0	0	1	0	27	47									
ZNF800	168850	broad.mit.edu	37	7	127014125	127014125	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:127014125G>C	uc003vlx.1	-	5	1528	c.1265C>G	c.(1264-1266)TCC>TGC	p.S422C	ZNF800_uc003vlw.1_Missense_Mutation_p.S325C|ZNF800_uc003vly.1_Missense_Mutation_p.S422C|ZNF800_uc010lla.2_Missense_Mutation_p.S422C	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGGGTAATGGAAGGGGGTGA	0.353		NaN											0	0	0	1	0	55	84									
KIAA1549	57670	broad.mit.edu	37	7	138604031	138604031	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:138604031G>C	uc011kql.1	-	2	390	c.341C>G	c.(340-342)TCT>TGT	p.S114C	KIAA1549_uc003vuk.3_Missense_Mutation_p.S64C|KIAA1549_uc011kqj.1_Missense_Mutation_p.S114C	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	114						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AGTAGTGGCAGACGGCGGGGC	0.517		NaN	O	BRAF	pilocytic astrocytoma								0	0	0	1	0	58	55									
KLRG2	346689	broad.mit.edu	37	7	139168067	139168067	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:139168067C>G	uc003vvb.2	-	1	391	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	KLRG2_uc010lnc.2_Missense_Mutation_p.E108Q	NM_198508	NP_940910	A4D1S0	KLRG2_HUMAN	killer cell lectin-like receptor subfamily G,	108	Pro-rich.					integral to membrane	sugar binding			central_nervous_system(1)	1	Melanoma(164;0.233)					CCGGGCGCCTCGCCATTCCGG	0.771		NaN											0	0	0	1	0	6	6									
DENND2A	27147	broad.mit.edu	37	7	140258011	140258011	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:140258011C>T	uc010lnj.2	-	9	2036	c.1891G>A	c.(1891-1893)GAA>AAA	p.E631K	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.E631K|DENND2A_uc003vvw.2_Missense_Mutation_p.E631K|DENND2A_uc003vvx.2_Missense_Mutation_p.E631K	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	631	UDENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GAGAATGTTTCACTGTGGTTG	0.473		NaN											0	0	0	1	0	29	32									
C7orf33	202865	broad.mit.edu	37	7	148288196	148288196	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:148288196T>A	uc003wew.2	+	1	540	c.179T>A	c.(178-180)TTG>TAG	p.L60*		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	60										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CAATTTAACTTGTCATATGCC	0.493		NaN											0	0	0	1	0	61	87									
ZNF777	27153	broad.mit.edu	37	7	149153043	149153043	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:149153043G>A	uc003wfv.2	-	2	234	c.71C>T	c.(70-72)CCT>CTT	p.P24L		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GAGTCCAGCAGGGGCCTGACG	0.547		NaN											0	0	0	1	0	39	54									
KRBA1	84626	broad.mit.edu	37	7	149419541	149419541	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:149419541G>A	uc003wfz.2	+	6	894	c.495G>A	c.(493-495)AGG>AGA	p.R165R	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_5'Flank	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	165										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCTACAAGGAAGGAAGGCC	0.607		NaN											0	0	0	1	0	3	9									
NOS3	4846	broad.mit.edu	37	7	150699303	150699303	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:150699303G>A	uc003wif.2	+	14	1959	c.1663G>A	c.(1663-1665)GAG>AAG	p.E555K	NOS3_uc011kuy.1_Missense_Mutation_p.E349K|NOS3_uc011kuz.1_Missense_Mutation_p.E555K|NOS3_uc011kva.1_Missense_Mutation_p.E555K|NOS3_uc011kvb.1_Missense_Mutation_p.E555K	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	555	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GTGTATGGATGAGTATGACGT	0.602		NaN											0	0	0	1	0	6	12									
MLL3	58508	broad.mit.edu	37	7	151877000	151877000	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:151877000C>G	uc003wla.2	-	37	7580	c.7361G>C	c.(7360-7362)AGA>ACA	p.R2454T	MLL3_uc003wkz.2_Missense_Mutation_p.R1515T|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2454	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AACAGCATATCTAGGTCCTAA	0.478		NaN	N		medulloblastoma								0	0	0	1	0	86	99									
MLL3	58508	broad.mit.edu	37	7	151878836	151878836	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:151878836C>G	uc003wla.2	-	36	6328	c.6109G>C	c.(6109-6111)GAT>CAT	p.D2037H	MLL3_uc003wkz.2_Missense_Mutation_p.D1098H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2037	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGACCACTATCAAGAGGTGCA	0.468		NaN	N		medulloblastoma								0	0	0	1	0	53	74									
MLL3	58508	broad.mit.edu	37	7	151945114	151945114	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:151945114G>A	uc003wla.2	-	14	2624	c.2405C>T	c.(2404-2406)TCA>TTA	p.S802L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	802					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACTAAGAGCTGAAGGGTAATT	0.423		NaN	N		medulloblastoma								0	0	0	1	0	37	740									
PCM1	5108	broad.mit.edu	37	8	17813081	17813081	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:17813081C>G	uc003wyi.3	+	10	1813	c.1391C>G	c.(1390-1392)TCT>TGT	p.S464C	PCM1_uc011kyh.1_Missense_Mutation_p.S464C|PCM1_uc003wyj.3_Missense_Mutation_p.S464C|PCM1_uc003wyh.2_Missense_Mutation_p.S503C|PCM1_uc010lta.1_Missense_Mutation_p.S503C	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	464					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		CTCACATCATCTGTTCCTTAT	0.433		NaN	T	RET|JAK2	papillary thyroid|CML|MPD								0	0	0	1	0	23	33									
CHD7	55636	broad.mit.edu	37	8	61654025	61654025	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:61654025G>A	uc003xue.2	+	2	511	c.34G>A	c.(34-36)GAG>AAG	p.E12K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	12					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCTTTTTGGCGAGGATGGGAA	0.488		NaN											0	0	0	1	0	13	9									
KCNB2	9312	broad.mit.edu	37	8	73848265	73848265	+	Silent	SNP	A	A	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:73848265A>G	uc003xzb.2	+	3	1263	c.675A>G	c.(673-675)GGA>GGG	p.G225G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	225					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACGAATTTGGACAACTCAATG	0.468		NaN											0	0	0	1	0	60	73									
RALYL	138046	broad.mit.edu	37	8	85785626	85785626	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:85785626G>C	uc003ycq.3	+	8	1095	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	RALYL_uc003ycr.3_Missense_Mutation_p.E227Q|RALYL_uc003ycs.3_Missense_Mutation_p.E227Q|RALYL_uc010lzy.2_Missense_Mutation_p.E216Q|RALYL_uc003yct.3_Missense_Mutation_p.E240Q|RALYL_uc003ycu.3_Missense_Mutation_p.E154Q|RALYL_uc003ycv.3_Missense_Mutation_p.E139Q	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	227	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						GCAGAAGGCGGAGGCAGGTAA	0.463		NaN											0	0	0	1	0	4	4									
ESRP1	54845	broad.mit.edu	37	8	95680397	95680397	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:95680397G>C	uc003ygq.3	+	10	1335	c.1152G>C	c.(1150-1152)CAG>CAC	p.Q384H	ESRP1_uc003ygr.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygs.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygt.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygu.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygv.2_Missense_Mutation_p.Q224H|ESRP1_uc003ygw.2_Missense_Mutation_p.Q224H	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	384	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AATATGCACAGAATGCGTTGA	0.458		NaN											0	0	0	1	0	47	50									
UBR5	51366	broad.mit.edu	37	8	103323975	103323975	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:103323975G>A	uc003ykr.1	-	19	2439	c.2406C>T	c.(2404-2406)TTC>TTT	p.F802F	UBR5_uc003yks.1_Silent_p.F802F	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	802					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GTCCAGCAGTGAAAATGGCTA	0.413		NaN											0	0	0	1	0	105	90									
PKHD1L1	93035	broad.mit.edu	37	8	110492333	110492333	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:110492333G>C	uc003yne.2	+	55	9396	c.9292G>C	c.(9292-9294)GAA>CAA	p.E3098Q		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3098	Extracellular (Potential).|G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCTTACAGAGAAGTTGTTTT	0.353		NaN								HNSCC(38;0.096)			0	0	0	1	0	5	3									
DEPDC6	64798	broad.mit.edu	37	8	120977541	120977541	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:120977541C>T	uc003yow.3	+	4	682	c.495C>T	c.(493-495)TTC>TTT	p.F165F	DEPDC6_uc011lid.1_Silent_p.F64F	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	165	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AGCGCACCTTCATGGCATCTG	0.532		NaN											0	0	0	1	0	41	61									
WISP1	8840	broad.mit.edu	37	8	134239872	134239872	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:134239872C>T	uc003yub.2	+	5	1099	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	WISP1_uc003yuc.2_Silent_p.F254F|WISP1_uc010meb.2_Silent_p.F169F|WISP1_uc010mec.2_3'UTR|WISP1_uc010med.2_Silent_p.F96F|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	341	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATGCCTGCTTCTGTAACCTGA	0.502		NaN											0	0	0	1	0	61	59									
NDRG1	10397	broad.mit.edu	37	8	134266798	134266798	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:134266798G>C	uc003yuh.2	-	9	1164	c.578C>G	c.(577-579)TCC>TGC	p.S193C	NDRG1_uc003yuf.1_Missense_Mutation_p.S4C|NDRG1_uc003yug.2_Missense_Mutation_p.S193C|NDRG1_uc010mee.2_Missense_Mutation_p.S112C|NDRG1_uc010mef.2_Missense_Mutation_p.S127C|NDRG1_uc011ljh.1_Missense_Mutation_p.S21C|NDRG1_uc011lji.1_Intron	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	193					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AAAAAGGTGGGACACCACCAT	0.537		NaN											0	0	0	1	0	24	35									
SLC45A4	57210	broad.mit.edu	37	8	142229062	142229062	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:142229062C>T	uc003ywd.1	-	4	832	c.524G>A	c.(523-525)TGG>TAG	p.W175*	SLC45A4_uc003ywc.1_Nonsense_Mutation_p.W175*|SLC45A4_uc010meq.1_Nonsense_Mutation_p.W173*	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	226					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGTCCGGAACCAGCTGCCCAG	0.647		NaN											0	0	0	1	0	89	89									
ZNF623	9831	broad.mit.edu	37	8	144732634	144732634	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:144732634C>G	uc003yzd.2	+	1	681	c.592C>G	c.(592-594)CAG>GAG	p.Q198E	ZNF623_uc011lkp.1_Missense_Mutation_p.Q158E|ZNF623_uc003yzc.2_Missense_Mutation_p.Q158E	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	198	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CATTGAGCATCAGCGCGTTCA	0.473		NaN											0	0	0	1	0	57	62									
EPPK1	83481	broad.mit.edu	37	8	144946756	144946756	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:144946756G>A	uc003zaa.1	-	1	679	c.666C>T	c.(664-666)CCC>CCT	p.P222P		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	222	Plectin 5.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCCCGAGCCGGGGGCACGCA	0.662		NaN											0	0	0	1	0	11	16									
EXOSC4	54512	broad.mit.edu	37	8	145134907	145134907	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:145134907C>T	uc003zau.2	+	2	343	c.233C>T	c.(232-234)TCA>TTA	p.S78L	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	78					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAATATAGTTCAGCGACCTTC	0.617		NaN											0	0	0	1	0	104	145									
NFKBIL2	4796	broad.mit.edu	37	8	145661307	145661307	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:145661307C>T	uc011llg.1	-	17	2524	c.2509G>A	c.(2509-2511)GAG>AAG	p.E837K	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	837					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			ATGTCCAGCTCCAGCCAGTCC	0.622		NaN											0	0	0	1	0	9	17									
DOCK8	81704	broad.mit.edu	37	9	446486	446486	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:446486C>G	uc003zgf.2	+	44	5809	c.5697C>G	c.(5695-5697)TTC>TTG	p.F1899L	DOCK8_uc010mgu.2_Missense_Mutation_p.F1201L|DOCK8_uc010mgv.2_Missense_Mutation_p.F1799L|DOCK8_uc003zgk.2_Missense_Mutation_p.F1357L	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1899					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CCACCCCGTTCACCCTGGAGG	0.522		NaN											0	0	0	1	0	67	99									
RFX3	5991	broad.mit.edu	37	9	3257090	3257090	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:3257090C>T	uc003zhr.2	-	15	2027	c.1715G>A	c.(1714-1716)TGG>TAG	p.W572*	RFX3_uc010mhd.2_Nonsense_Mutation_p.W572*|RFX3_uc003zhs.1_Nonsense_Mutation_p.W572*	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	572					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		ATTGTCAAGCCACGCAGCCCA	0.498		NaN											0	0	0	1	0	64	71									
FREM1	158326	broad.mit.edu	37	9	14824958	14824958	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:14824958G>A	uc003zlm.2	-	11	2504	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	638	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTGGAAGCTGGTCATCCACTG	0.383		NaN											0	0	0	1	0	28	33									
PTPLAD2	401494	broad.mit.edu	37	9	21007098	21007098	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:21007098G>T	uc010miq.1	-	7	683	c.637C>A	c.(637-639)CAT>AAT	p.H213N	PTPLAD2_uc003zoj.1_Missense_Mutation_p.H176N|PTPLAD2_uc010mir.1_Missense_Mutation_p.H213N	NM_001010915	NP_001010915	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain	213	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			skin(1)	1				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		GAGTATAGATGACTGTAGGTA	0.348		NaN											1	0	2.80507e-11	1	2.86585e-11	27	50									
UBAP2	55833	broad.mit.edu	37	9	33927842	33927842	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:33927842G>A	uc003ztq.1	-	20	2437	c.2324C>T	c.(2323-2325)GCG>GTG	p.A775V	UBAP2_uc011loc.1_Missense_Mutation_p.A684V|UBAP2_uc011lod.1_Missense_Mutation_p.A508V|UBAP2_uc011loe.1_Missense_Mutation_p.A530V|UBAP2_uc011lof.1_Missense_Mutation_p.A700V|UBAP2_uc011log.1_3'UTR|UBAP2_uc003ztn.1_Missense_Mutation_p.A14V|UBAP2_uc003zto.1_Missense_Mutation_p.A14V|UBAP2_uc003ztp.1_Missense_Mutation_p.A14V	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	775										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GGATGCACTCGCGGGGGTCCC	0.642		NaN											0	0	0	1	0	84	106									
KIAA1045	23349	broad.mit.edu	37	9	34976667	34976667	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:34976667G>A	uc003zvq.2	+	5	957	c.779G>A	c.(778-780)CGA>CAA	p.R260Q	KIAA1045_uc003zvr.2_Missense_Mutation_p.R260Q	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	260							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			CCTGAACATCGAGGCCACATA	0.632		NaN											0	0	0	1	0	51	77									
SMC5	23137	broad.mit.edu	37	9	72962016	72962016	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:72962016T>C	uc004ahr.2	+	20	2720	c.2603T>C	c.(2602-2604)ATT>ACT	p.I868T	SMC5_uc011lry.1_Missense_Mutation_p.I13T	NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	868					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						TTGGATGAAATTGATGCTTTA	0.368		NaN											0	0	0	1	0	31	34									
TRPM6	140803	broad.mit.edu	37	9	77390846	77390846	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:77390846C>A	uc004ajl.1	-	24	3594	c.3356G>T	c.(3355-3357)TGC>TTC	p.C1119F	TRPM6_uc004ajk.1_Missense_Mutation_p.C1114F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.C75F	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1119	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TCGATGACAGCACAGGCGGCG	0.542		NaN											1	0	2.40265e-35	1	2.54814e-35	50	100									
PCSK5	5125	broad.mit.edu	37	9	78796359	78796359	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:78796359G>C	uc004ajz.2	+	16	2587	c.2049G>C	c.(2047-2049)AAG>AAC	p.K683N	PCSK5_uc004aka.2_RNA|PCSK5_uc004akb.2_5'UTR	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	683	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						ACGCCGACAAGAAGCGCTGCA	0.522		NaN											0	0	0	1	0	26	52									
PSAT1	29968	broad.mit.edu	37	9	80912185	80912185	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:80912185C>G	uc004ala.2	+	1	127	c.59C>G	c.(58-60)TCA>TGA	p.S20*	PSAT1_uc004alb.2_Nonsense_Mutation_p.S20*	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1 isoform 1	20					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	CTGCCGCACTCAGTAAGTCCC	0.697		NaN											0	0	0	1	0	14	14									
KIF27	55582	broad.mit.edu	37	9	86485462	86485462	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:86485462C>G	uc004ana.2	-	12	2873	c.2729G>C	c.(2728-2730)GGT>GCT	p.G910A	KIF27_uc010mpw.2_Missense_Mutation_p.G844A|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	910					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TCCAAACGAACCTTTTCTCCT	0.348		NaN											0	0	0	1	0	26	34									
ANP32B	10541	broad.mit.edu	37	9	100756947	100756947	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:100756947A>T	uc004aya.2	+	2	438	c.89A>T	c.(88-90)AAT>ATT	p.N30I		NM_006401	NP_006392	Q92688	AN32B_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	30	LRR 1.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(62;0.0559)				TGCAAATCAAATGATGGAAAA	0.363		NaN											0	0	0	1	0	32	52									
OR13C4	138804	broad.mit.edu	37	9	107289386	107289386	+	Silent	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:107289386G>A	uc011lvn.1	-	1	105	c.105C>T	c.(103-105)TAC>TAT	p.Y35Y		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAATCACTACGTACATAACTA	0.413		NaN											0	0	0	1	0	68	81									
FBXW2	26190	broad.mit.edu	37	9	123550366	123550366	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:123550366G>C	uc004bkl.1	-	3	332	c.171C>G	c.(169-171)CTC>CTG	p.L57L	FBXW2_uc011lyc.1_5'UTR|FBXW2_uc004bkn.2_Silent_p.L89L|FBXW2_uc004bkm.1_Silent_p.L57L|FBXW2_uc010mvj.1_Silent_p.L57L	NM_012164	NP_036296	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2	57	F-box.				proteolysis		protein binding|ubiquitin-protein ligase activity			urinary_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						GAAGGAGTTTGAGGAAGTCCC	0.463		NaN											0	0	0	1	0	45	64									
C5	727	broad.mit.edu	37	9	123737147	123737147	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:123737147C>G	uc004bkv.2	-	30	3957	c.3927G>C	c.(3925-3927)TTG>TTC	p.L1309F		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1309					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TGTCCATACTCAAGCGGAGTT	0.403		NaN											0	0	0	1	0	101	131									
ZBTB6	10773	broad.mit.edu	37	9	125673538	125673538	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:125673538C>G	uc004bnh.2	-	2	903	c.814G>C	c.(814-816)GAT>CAT	p.D272H		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGCCCTGATCTTGATTCCCA	0.428		NaN											0	0	0	1	0	23	39									
ZBTB6	10773	broad.mit.edu	37	9	125673781	125673781	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:125673781C>G	uc004bnh.2	-	2	660	c.571G>C	c.(571-573)GAG>CAG	p.E191Q		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCAGACTCTCTACTGTAGAC	0.353		NaN											0	0	0	1	0	35	36									
GOLGA1	2800	broad.mit.edu	37	9	127689002	127689002	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:127689002C>G	uc004bpc.2	-	7	760	c.418G>C	c.(418-420)GAT>CAT	p.D140H	GOLGA1_uc010mws.2_RNA|GOLGA1_uc010mwt.1_Missense_Mutation_p.D115H	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	140	Potential.					Golgi cisterna membrane				ovary(1)	1						TCAAGCTGATCCATCTTTTCT	0.343		NaN											0	0	0	1	0	53	113									
GOLGA1	2800	broad.mit.edu	37	9	127691529	127691529	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:127691529C>T	uc004bpc.2	-	5	609	c.267G>A	c.(265-267)GAG>GAA	p.E89E	GOLGA1_uc010mws.2_5'Flank|GOLGA1_uc010mwt.1_Intron	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	89	Potential.					Golgi cisterna membrane				ovary(1)	1						TTTCAAGCTTCTCTTTTATCT	0.368		NaN											0	0	0	1	0	5	41									
GOLGA1	2800	broad.mit.edu	37	9	127691531	127691531	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:127691531C>T	uc004bpc.2	-	5	607	c.265G>A	c.(265-267)GAG>AAG	p.E89K	GOLGA1_uc010mws.2_5'Flank|GOLGA1_uc010mwt.1_Intron	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	89	Potential.					Golgi cisterna membrane				ovary(1)	1						TCAAGCTTCTCTTTTATCTTC	0.363		NaN											0	0	0	1	0	5	42									
NUP188	23511	broad.mit.edu	37	9	131767776	131767776	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:131767776C>T	uc004bws.1	+	40	4726	c.4704C>T	c.(4702-4704)TTC>TTT	p.F1568F		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1568					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TGCGCCACTTCACCCCAGATG	0.577		NaN											0	0	0	1	0	40	61									
BARHL1	56751	broad.mit.edu	37	9	135464731	135464731	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:135464731C>G	uc004cbp.1	+	3	998	c.806C>G	c.(805-807)TCC>TGC	p.S269C		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	269						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		AGTCTGGTTTCCAACCTGGAC	0.672		NaN											0	0	0	1	0	90	99									
CEL	1056	broad.mit.edu	37	9	135947083	135947083	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:135947083G>A	uc010naa.1	+	11	2219	c.2203G>A	c.(2203-2205)GAG>AAG	p.E735K		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	732	16.|17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GGGTGACTCTGAGGCTGCCCC	0.682		NaN											0	0	0	1	0	27	30									
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607		NaN											0	0	0	1	0	71	105									
SDCCAG3	10807	broad.mit.edu	37	9	139303520	139303520	+	Splice_Site	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:139303520C>G	uc004chi.2	-	3	426	c.221_splice	c.e3-1	p.D74_splice	SDCCAG3_uc004chj.2_Intron|SDCCAG3_uc004chk.2_Intron|PMPCA_uc011mdy.1_5'Flank|PMPCA_uc010nbk.2_5'Flank|PMPCA_uc004chl.2_5'Flank|PMPCA_uc010nbl.2_5'Flank|PMPCA_uc011mdz.1_5'Flank	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3							cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		TAGCCAAAATCTGCAAAGAAA	0.458		NaN											0	0	0	1	0	47	96									
MAN1B1	11253	broad.mit.edu	37	9	140003028	140003028	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:140003028C>G	uc004cld.2	+	13	2120	c.2085C>G	c.(2083-2085)ATC>ATG	p.I695M	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.I368M|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	695	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CTCTGCCTATCTGGACCCCTG	0.597		NaN											0	0	0	1	0	121	153									
RNF208	727800	broad.mit.edu	37	9	140115104	140115104	+	Silent	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:140115104G>C	uc004clz.1	-	1	672	c.561C>G	c.(559-561)CCC>CCG	p.P187P		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	187	RING-type.						zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGCGGCAGGTGGGGCAGGAGA	0.652		NaN											0	0	0	1	0	14	42									
RNF208	727800	broad.mit.edu	37	9	140115581	140115581	+	Silent	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:140115581G>T	uc004clz.1	-	1	195	c.84C>A	c.(82-84)CTC>CTA	p.L28L		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	28							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CCTCCATCTTGAGGATGACAT	0.662		NaN											1	0	0.00152264	1	0.00153264	17	22									
OFD1	8481	broad.mit.edu	37	X	13757019	13757019	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:13757019C>G	uc004cvp.3	+	4	726	c.367C>G	c.(367-369)CTC>GTC	p.L123V	OFD1_uc004cvr.3_5'UTR|OFD1_uc011mil.1_5'UTR|OFD1_uc004cvq.3_5'UTR|OFD1_uc010nen.2_Missense_Mutation_p.L122V|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.L122V|OFD1_uc004cvv.3_Missense_Mutation_p.L122V	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	123					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						TACTTCCAGTCTCTACAAATC	0.284		NaN											0	0	0	1	0	63	5									
CYBB	1536	broad.mit.edu	37	X	37664367	37664367	+	Silent	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:37664367C>T	uc004ddr.2	+	10	1321	c.1260C>T	c.(1258-1260)CTC>CTT	p.L420L	CYBB_uc011mkf.1_Silent_p.L388L|CYBB_uc011mkg.1_Silent_p.L153L	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	420	Cytoplasmic (Potential).		L -> P (in XCGD).		electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CATCCATTCTCAAGTCAGTCT	0.473		NaN											0	0	0	1	0	39	6									
KDM6A	7403	broad.mit.edu	37	X	44918318	44918318	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:44918318G>C	uc004dge.3	+	11	1318	c.943G>C	c.(943-945)GAA>CAA	p.E315Q	KDM6A_uc010nhk.2_Missense_Mutation_p.E315Q|KDM6A_uc011mkz.1_Missense_Mutation_p.E315Q|KDM6A_uc011mla.1_Missense_Mutation_p.E315Q|KDM6A_uc011mlb.1_Missense_Mutation_p.E315Q|KDM6A_uc011mlc.1_Missense_Mutation_p.E64Q|KDM6A_uc011mld.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	315	TPR 6.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGATAAATCAGAAGCAAGTGC	0.328		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	1	0	42	7									
KDM6A	7403	broad.mit.edu	37	X	44941858	44941858	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:44941858C>G	uc004dge.3	+	21	3557	c.3182C>G	c.(3181-3183)TCA>TGA	p.S1061*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.S1113*|KDM6A_uc011mla.1_Nonsense_Mutation_p.S1016*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.S1068*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.S765*|KDM6A_uc011mld.1_Nonsense_Mutation_p.S700*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1061					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAGACCACTCAGATAGTGAA	0.313		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	1	0	39	4									
CXorf36	79742	broad.mit.edu	37	X	45010958	45010958	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:45010958C>G	uc004dgg.2	-	5	1316	c.1241G>C	c.(1240-1242)AGA>ACA	p.R414T		NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	414						extracellular region				lung(1)	1						GTCACACGTTCTCAGGGGCCT	0.537		NaN											0	0	0	1	0	96	11									
RGAG4	340526	broad.mit.edu	37	X	71350506	71350506	+	Silent	SNP	G	G	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:71350506G>T	uc010nlh.1	-	1	1246	c.885C>A	c.(883-885)GCC>GCA	p.A295A	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	295										ovary(2)|skin(1)	3	Renal(35;0.156)					CATCCAGGTCGGCCATTTCTG	0.493		NaN											1	0	6.60522e-78	1	7.10351e-78	127	7									
DCAF12L2	340578	broad.mit.edu	37	X	125299171	125299171	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:125299171C>T	uc004euk.1	-	1	764	c.737G>A	c.(736-738)CGT>CAT	p.R246H		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	246										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ATCCCTCGGACGGATGTGGGC	0.647		NaN											0	0	0	1	0	29	0									
GPR101	83550	broad.mit.edu	37	X	136113144	136113144	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:136113144C>G	uc011mwh.1	-	1	690	c.690G>C	c.(688-690)AAG>AAC	p.K230N		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	230	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGCTGTGTCTCTTGACATTGT	0.522		NaN											0	0	0	1	0	114	11									
DDX10	1662	broad.mit.edu	37	11	108788635	108788637	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:108788635_108788637delTGA	uc001pkm.2	+	17	2405_2407	c.2340_2342delTGA	c.(2338-2343)AGTGAT>AGT	p.D788del	DDX10_uc001pkl.1_In_Frame_Del_p.D788del	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	788							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGGATTGGAGtgatgatgatgat	0.31		NaN	T	NUP98	AML*								NaN	NaN	NaN	NaN	NaN	7	45	---	---							
ADAM21	8747	broad.mit.edu	37	14	70924869	70924871	+	In_Frame_Del	DEL	ATG	ATG	-	rs141326765		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:70924869_70924871delATG	uc001xmd.2	+	1	653_655	c.653_655delATG	c.(652-657)CATGAT>CAT	p.D219del		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	219	Peptidase M12B.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GTGGTGAACCATGATTTCTTCAT	0.414		NaN											NaN	NaN	NaN	NaN	NaN	7	177	---	---							
MSL1	339287	broad.mit.edu	37	17	38289813	38289822	+	Frame_Shift_Del	DEL	AAAGAATTTT	AAAGAATTTT	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:38289813_38289822delAAAGAATTTT	uc002hub.2	+	7	999_1008	c.980_989delAAAGAATTTT	c.(979-990)CAAAGAATTTTAfs	p.Q327fs	MSL1_uc002hua.3_Frame_Shift_Del_p.Q265fs|MSL1_uc002hud.2_Frame_Shift_Del_p.Q67fs	NM_001012241	NP_001012241	Q68DK7	MSL1_HUMAN	hampin	528_531					histone H4-K16 acetylation	MSL complex					0						ATCAGGGAACAAAGAATTTTACAGCGACTG	0.39		NaN											NaN	NaN	NaN	NaN	NaN	9	3	---	---							
SCRN2	90507	broad.mit.edu	37	17	45915767	45915767	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:45915767delG	uc002imd.2	-	7	1114	c.988delC	c.(988-990)CAGfs	p.Q330fs	SCRN2_uc002imc.2_Frame_Shift_Del_p.Q338fs|SCRN2_uc002imf.2_Frame_Shift_Del_p.Q330fs|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	330					proteolysis		dipeptidase activity			ovary(1)	1						GACAGCACCTGGGGGGCCTGG	0.577		NaN											NaN	NaN	NaN	NaN	NaN	245	59	---	---							
LMAN1	3998	broad.mit.edu	37	18	57013193	57013194	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:57013193_57013194insT	uc002lhz.2	-	8	944_945	c.912_913insA	c.(910-915)AAAGAGfs	p.K304fs		NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	304_305	Lumenal (Potential).				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TGGAATTCCTCTTTTTTTTTAT	0.455		NaN											NaN	NaN	NaN	NaN	NaN	7	134	---	---							
ZNF615	284370	broad.mit.edu	37	19	52505446	52505447	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:52505446_52505447insC	uc002pye.1	-	4	395_396	c.103_104insG	c.(103-105)GACfs	p.D35fs	ZNF615_uc002pyf.1_Frame_Shift_Ins_p.D35fs|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Frame_Shift_Ins_p.D35fs|ZNF615_uc010epi.1_Frame_Shift_Ins_p.D31fs|ZNF615_uc010ydg.1_Frame_Shift_Ins_p.D40fs	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CAACATCACGTCCCGGTACAGG	0.564		NaN											NaN	NaN	NaN	NaN	NaN	204	180	---	---							
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:29295647_29295649delTCC	uc002rmt.1	-	1	1479_1481	c.1479_1481delGGA	c.(1477-1482)GAGGAA>GAA	p.493_494EE>E		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	493_494					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						CATTTTGTCTTCCTCCTCCTCCT	0.542		NaN											NaN	NaN	NaN	NaN	NaN	7	265	---	---							
KDM3A	55818	broad.mit.edu	37	2	86693893	86693894	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:86693893_86693894insA	uc002sri.3	+	10	1733_1734	c.1406_1407insA	c.(1405-1407)GGAfs	p.G469fs	KDM3A_uc010ytj.1_Frame_Shift_Ins_p.G469fs|KDM3A_uc010ytk.1_Frame_Shift_Ins_p.G417fs	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	469					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						AACTGTTCAGGAAAAAAGGTAG	0.401		NaN											NaN	NaN	NaN	NaN	NaN	41	87	---	---							
DYNC1LI1	51143	broad.mit.edu	37	3	32571050	32571050	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:32571050delT	uc003cfb.3	-	11	1376	c.1288delA	c.(1288-1290)ATTfs	p.I430fs	DYNC1LI1_uc011axh.1_Frame_Shift_Del_p.I314fs	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	430					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						TTTGGATCAATTTTTTTTGAC	0.398		NaN											NaN	NaN	NaN	NaN	NaN	8	78	---	---							
ZNF608	57507	broad.mit.edu	37	5	124079813	124079815	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:124079813_124079815delCTC	uc003ktq.1	-	1	991_993	c.868_870delGAG	c.(868-870)GAGdel	p.E290del	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_In_Frame_Del_p.E290del|ZNF608_uc003ktt.1_In_Frame_Del_p.E290del	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	290	Potential.					intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCTGTGGCTCTCCTCCTCCTCC	0.522		NaN											NaN	NaN	NaN	NaN	NaN	11	339	---	---							
BAT5	7920	broad.mit.edu	37	6	31660894	31660894	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:31660894delC	uc003nvy.1	-	7	566	c.536delG	c.(535-537)GGTfs	p.G179fs	BAT5_uc003nvx.1_5'UTR|BAT5_uc011dny.1_Frame_Shift_Del_p.G146fs|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_5'UTR|BAT5_uc010jtc.1_RNA|BAT5_uc011doa.1_Frame_Shift_Del_p.V81fs	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	179						integral to membrane	hydrolase activity|protein binding				0						CAGGGCCACACCCCGGCGGGA	0.622		NaN											NaN	NaN	NaN	NaN	NaN	24	66	---	---							
IRS4	8471	broad.mit.edu	37	X	107977802	107977803	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:107977802_107977803insC	uc004eoc.2	-	1	1805_1806	c.1772_1773insG	c.(1771-1773)GGCfs	p.G591fs		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	591						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTGAGCCTTTGCCCCCCCCAGA	0.545		NaN											NaN	NaN	NaN	NaN	NaN	8	409	---	---